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https://www.readbyqxmd.com/read/29774122/the-down-regulation-of-the-cyp2c19-gene-is-associated-with-aggressive-tumor-potential-and-the-poorer-recurrence-free-survival-of-hepatocellular-carcinoma
#1
Ryo Ashida, Yukiyasu Okamura, Keiichi Ohshima, Yuko Kakuda, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Takashi Sugino, Kenichi Urakami, Masatoshi Kusuhara, Ken Yamaguchi
Project HOPE (High-tech Omics-based Patient Evaluation) began in 2014 using integrated gene expression profiling (GEP) of cancer tissues as well as diathesis of each patient who underwent an operation at our institution. The aim of this study was to clarify the association between the expression of cytochrome P450s (CYP) genes and recurrence of hepatocellular carcinoma (HCC). The present study included 92 patients. Genes with aberrant expression were selected based on a ≥10-fold difference in the expression between tumor and non-tumor tissues...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29769713/author-correction-discovery-of-a-selective-catalytic-p300-cbp-inhibitor-that-targets-lineage-specific-tumours
#2
Loren M Lasko, Clarissa G Jakob, Rohinton P Edalji, Wei Qiu, Debra Montgomery, Enrico L Digiammarino, T Matt Hansen, Roberto M Risi, Robin Frey, Vlasios Manaves, Bailin Shaw, Mikkel Algire, Paul Hessler, Lloyd T Lam, Tamar Uziel, Emily Faivre, Debra Ferguson, Fritz G Buchanan, Ruth L Martin, Maricel Torrent, Gary G Chiang, Kannan Karukurichi, J William Langston, Brian T Weinert, Chunaram Choudhary, Peter de Vries, Arthur F Kluge, Michael A Patane, John H Van Drie, Ce Wang, David McElligott, Edward A Kesicki, Ronen Marmorstein, Chaohong Sun, Philip A Cole, Saul H Rosenberg, Michael R Michaelides, Albert Lai, Kenneth D Bromberg
In the originally published version of this Letter, the authors Arthur F. Kluge, Michael A. Patane and Ce Wang were inadvertently omitted from the author list. Their affiliations are: I-to-D, Inc., PO Box 6177, Lincoln, Massachusetts 01773, USA (A.F.K.); Mitobridge, Inc. 1030 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA (M.A.P.); and China Novartis Institutes for BioMedical Research, No. 4218 Jinke Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai 201203, China (C.W.). These authors contributed to the interpretation of results and design of compounds...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29767430/ultra-narrow-band-blue-emitting-oxoberyllates-aeli2-be4o6-eu2-ae-sr-ba-paving-the-way-to-efficient-rgb-pc-leds
#3
Philipp Strobel, Christian Maak, Volker Weiler, Peter J Schmidt, Wolfgang Schnick
Highly efficient phosphor-converted light-emitting diodes (pc-LEDs) are popular in lighting and high-tech electronics applications. The main goals of present LED research are increasing light quality, preserving color point stability and reducing energy consumption. For those purposes excellent phosphors in all spectral regions are required. Here, we report on ultra-narrow band blue emitting oxoberyllates AELi2[Be4O6]:Eu2+ (AE = Sr,Ba) exhibiting a rigid covalent network isotypic to the nitridoalumosilicate BaLi2[(Al2Si2)N6]:Eu2+...
May 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29764957/examining-perceptions-about-iqos-heated-tobacco-product-consumer-studies-in-japan-and-switzerland
#4
Elizabeth C Hair, Morgane Bennett, Emily Sheen, Jennifer Cantrell, Jodie Briggs, Zoe Fenn, Jeffrey G Willett, Donna Vallone
OBJECTIVE: To examine consumer perceptions, attitudes and behaviours regarding the heated tobacco product, IQOS, as well as to document the product's marketing strategies to determine its potential for appealing to youth and young adults. METHOD: Truth Initiative, in collaboration with Flamingo, collected qualitative data via: (1) expert interviews, (2) semiotic analysis of IQOS packing and marketing materials, and (3) 12 focus groups with adults in Switzerland (ages 19-44 years; June 6-9, 2016) and Japan (ages 20-39 years; June 22-24, 2016) (n=68 for both groups)...
May 15, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29757504/a-comparison-of-the-nzi-horse-pal-%C3%A2-and-bite-lite-%C3%A2-h-traps-and-selected-baits-for-the-collection-of-adult-tabanidae-in-florida-and-north-carolina
#5
Daniel L Kline, Jerome A Hogsette, Donald A Rutz
Despite the veterinary and medical importance of horse flies, deer flies, and yellow flies, only a few trap types have been evaluated to monitor adult population dynamics. Currently, three trap types are being utilized (H-trap, Horse Pal® (HP), and Nzi trap), but no head-to-head comparisons have been reported. Thus, we conducted comparative trapping studies in Florida and North Carolina. At two study sites in Florida, the efficacy of all three trap types was compared, but only the H-trap and HP were compared in North Carolina...
June 2018: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/29754410/hi-tech-restoration-by-two-steps-biocleaning-process-of-triumph-of-death-fresco-at-the-camposanto-monumental-cemetery-pisa-italy
#6
Giancarlo Ranalli, Elisabetta Zanardini, Alessia Andreotti, Maria Perla Colombini, Cristina Corti, Pilar Bosch-Roig, Paola De Nuntiis, Giuseppe Lustrato, Paolo Mandrioli, Laura Rampazzi, Carlo Giantomassi, Donatella Zari
AIMS: In this work, the "hi-tech" complex biocleaning and restoration of the 14th-century fresco Triumph of Death (5.6x15.0 m) at the Camposanto Monumental Cemetery (Pisa, Italy) is reported. Since 2000, the restoration based on the biological cleaning of noble medieval frescoes, has been successfully utilized in this site. METHODS AND RESULTS: The novelty of this study is the 2-steps biocleaning process using Pseudomonas stutzeri A29 viable cells, previously applied for recovering other valuable frescoes...
May 13, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29733948/predictive-models-of-lyophilization-process-for-development-scale-up-tech-transfer-and-manufacturing
#7
Tong Zhu, Ehab M Moussa, Madeleine Witting, Deliang Zhou, Kushal Sinha, Mario Hirth, Martin Gastens, Sherwin Shang, Nandkishor Nere, Shubha Chetan Somashekar, Alina Alexeenko, Feroz Jameel
Scale-up and technology transfer of lyophilization processes remains a challenge that requires thorough characterization of the laboratory and larger scale lyophilizers. In this study, computational fluid dynamics (CFD) was employed to develop computer-based models of both laboratory and manufacturing scale lyophilizers in order to understand the differences in equipment performance arising from distinct designs. CFD coupled with steady state heat and mass transfer modeling of the vial were then utilized to study and predict independent variables such as shelf temperature and chamber pressure, and response variables such as product resistance, product temperature and primary drying time for a given formulation...
May 4, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29727838/pattern-of-blood-concentrations-of-47-elements-in-two-populations-from-the-same-geographical-area-but-with-different-geological-origin-and-lifestyles-canary-islands-spain-vs-morocco
#8
Luis Alberto Henríquez-Hernández, Ana González-Antuña, Luis D Boada, Cristina Carranza, José Luis Pérez-Arellano, Maira Almeida-González, María Camacho, Manuel Zumbado, Fernando Fernández-Fuertes, Manuel Tapia-Martín, Octavio P Luzardo
The Canary Islands are one of the outermost regions of the European Union (EU), which are located barely 100 km from the coasts of Morocco. Although these islands are located in Africa, the degree of socioeconomic development and lifestyle in this archipelago is comparable to that of any other region of Europe. It is well established that the main determinants of human exposure to elements have to do both, with their place of residence and with habits related to their lifestyle. For this reason, we wanted to study the pattern of contamination by elements of these two populations so geographically close, but so different both in their lifestyle, and the geological origin of the territory where they live...
May 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29716555/efficacy-and-safety-outcomes-of-robotic-radical-hysterectomy-in-chinese-older-women-with-cervical-cancer-compared-with-laparoscopic-radical-hysterectomy
#9
Cheng Luo, Mei Liu, Xiuli Li
BACKGROUND: Recently, as a complex integrating a number of modern high-tech means, robotic surgery system is a well-deserved revolutionary tool in globally minimally invasive surgical field. For the first time in China, the objective of this study was to evaluate the efficacy and safety outcomes of robotic radical hysterectomy (RRH) in Chinese older women with cervical cancer compared with laparoscopic radical hysterectomy (LRH). METHODS: In this prospective, randomized and double-blinded study, 60 Chinese older women with cervical cancer were evenly divided to accept the RRH or LRH...
May 1, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29713341/use-of-telemedicine-in-addiction-treatment-current-practices-and-organizational-implementation-characteristics
#10
Todd Molfenter, Roger Brown, Andrew O'Neill, Ed Kopetsky, Alexander Toy
Telemedicine applications offer innovative approaches for treating and reducing the effects of substance use disorders (SUDs). This analysis assessed the interest in and use of 11 telemedicine applications in a sample of 363 SUD organizations in the United States of America. Fifty percent of the organizations expressed high rates of interest in seven of the telemedicine applications, demonstrating the appeal of telemedicine within this field. The top three self-reported telemedicine applications being used were (1) computerized screening/assessments (44...
2018: International Journal of Telemedicine and Applications
https://www.readbyqxmd.com/read/29713179/levodopa-carbidopa-entacapone-versus-levodopa-dopa-decarboxyiase-inhibitor-for-the-treatment-of-parkinson-s-disease-systematic-review-meta-analysis-and-economic-evaluation
#11
Zhan-Miao Yi, Ting-Ting Qiu, Yuan Zhang, Na Liu, Suo-Di Zhai
Aims: To review the evidence for efficacy, safety, and cost-effectiveness of levodopa/carbidopa/entacapone (LCE) compared with levodopa/dopa-decarboxyiase inhibitor (DDCI) for Parkinson's disease (PD). Methods: PubMed, Embase, the Cochrane Library, and Chinese databases WangFang Data, Chinese Sci-tech Journals Database and China National Knowledge Infrastructure, as well as ClinicalTrials.gov, were searched for randomized controlled trials with "levodopa/carbidopa/entacapone" as keywords...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29705642/rare-earth-elements-in-german-soils-a-review
#12
Julia Mihajlovic, Jörg Rinklebe
Rare earth elements (REEs) are increasingly used in high-tech industry, agriculture, and healthcare technologies what leads to their release into soils and waters, and to the transfer into plants what may have negative impacts on human health and the environment. The toxicity and potential mobilization of REEs in soils can be assessed by their content and geochemical behavior along with soil properties. However, those interactions are so far not reviewed in German soils although such a review is important for a better understanding and prediction of the potential mobilization and toxicity...
April 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29697288/a-systematic-quality-review-of-high-tech-aac-interventions-as-an-evidence-based-practice
#13
Kristi L Morin, Jennifer B Ganz, Emily V Gregori, Margaret J Foster, Stephanie L Gerow, Derya Genç-Tosun, Ee Rea Hong
Although high-tech augmentative and alternative communication (AAC) is commonly used to teach social-communication skills to people with autism spectrum disorder or intellectual disabilities who have complex communication needs, there is a critical need to evaluate the efficacy of this approach. The aim of this systematic review was to evaluate the quality of single-case experimental design research on the use of high-tech AAC to teach social-communication skills to individuals with autism spectrum disorder or intellectual disabilities who have complex communication needs, to determine if this intervention approach meets the criteria for evidence-based practices as outlined by the What Works Clearinghouse...
April 26, 2018: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/29692170/widespread-atmospheric-tellurium-contamination-in-industrial-and-remote-regions-of-canada
#14
Johan A Wiklund, Jane L Kirk, Derek C G Muir, Jacques Carrier, Amber Gleason, Fan Yang, Marlene Evans, Jonathan Keating
High tech applications, primarily photovoltaics, have greatly increased demand for the rare and versatile but toxic element tellurium (Te). Here we examine dated lake sediment Te concentration profiles collected near potential point sources (metal smelters, coal mining/combustion facilities, oil sands operations) and from rural regions and remote natural areas of Canada. Te contamination was most prevalent near a Cu/Zn smelter where observed deposition infers 21 g Te released per metric ton (t) of Cu processed...
April 25, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29691433/pedot-pss-graphene-quantum-dots-films-with-enhanced-thermoelectric-properties-via-strong-interfacial-interaction-and-phase-separation
#15
Fei-Peng Du, Nan-Nan Cao, Yun-Fei Zhang, Ping Fu, Yan-Guang Wu, Zhi-Dong Lin, Run Shi, Abbas Amini, Chun Cheng
The typical conductive polymer of PEDOT:PSS has recently attracted intensive attention in thermoelectric conversion because of its low cost and low thermal conductivity as well as high electrical conductivity. However, compared to inorganic counterparts, the relatively poor thermoelectric performance of PEDOT:PSS has greatly limited its development and high-tech applications. Here, we report a dramatic enhancement in the thermoelectric performance of PEDOT:PSS by constructing unique composite films with graphene quantum dots (GQDs)...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29684645/challenges-in-pediatric-neuroimaging
#16
REVIEW
Matthew J Barkovich, Yi Li, Rahul S Desikan, A James Barkovich, Duan Xu
Pediatric neuroimaging is challenging due the rapid structural, metabolic, and functional changes that occur in the developing brain. A specially trained team is needed to produce high quality diagnostic images in children, due to their small physical size and immaturity. Patient motion, cooperation and medical condition dictate the methods and equipment used. A customized approach tailored to each child's age and functional status with the appropriate combination of dedicated staff, imaging hardware, and software is key; these range from low-tech techniques, such as feed and swaddle, to specialized small bore MRI scanners, MRI compatible incubators and neonatal head coils...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29681786/information-management-for-the-assistive-technology-provision-in-community-perspectives-of-local-policymakers-and-health-service-providers
#17
Suchitporn Lersilp, Supawadee Putthinoi, Sayaka Okahashi
Background: Assistive technology (AT) is a way to enhance the performance of daily activities in people with disabilities and help them live more independently. However, an important problem in providing AT lies in the effectiveness of information management. Local policymakers and health service providers have become aware of this problem and their perspectives are the key to solving it. Methods: This study explored the types of AT provided for people with disabilities in the community and the perspectives on information management of local policymakers and health service providers...
2018: Occupational Therapy International
https://www.readbyqxmd.com/read/29681189/autism-inside-out-lessons-from-the-memoirs-of-three-minimally-verbal-youths
#18
Christie Welch, Helene Polatajko, Patty Rigby, Margaret Fitch
BACKGROUND: To date, research exploring experiences and perspectives of people who have severe autism and are minimally verbal, has been sparse. OBJECTIVES: To build new understanding based on insider perspectives of people who have severe autism and are minimally verbal. We took interest in how these perspectives support, challenge, or augment current depictions of autism in academic literature. METHOD: Adopting a descriptive qualitative approach, three memoirs written by youths who have severe autism and are minimally verbal were examined using inductive thematic analysis...
April 23, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29676114/-pharmacological-effect-of-combined-administration-of-natures-tastes-and-components-of-chinese-herbal-compounds
#19
REVIEW
Chun-Yan Lv, Shao-Wa Lv, Guo-Yu Li, Hai-Xue Kuang
The combined administration of traditional Chinese medicine (TCM) aims at comprehensive adjustment of body based on the theory of TCM and the theory of Chinese medicine property. The natures and tastes of TCM are the core of the theory of TCM property. The combined administration of natures and tastes of TCM is one of the important theories of prescription compatibility. The objective of study on the combined administration of natures and tastes of prescriptions according to symptoms of disease is to clarify the compatibility mechanism of prescriptions...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29674309/measuring-risky-driving-behavior-using-an-mhealth-smartphone-app-development-and-evaluation-of-gforce
#20
Raisa Z Freidlin, Amisha D Dave, Benjamin G Espey, Sean T Stanley, Marcial A Garmendia, Randall Pursley, Johnathon P Ehsani, Bruce G Simons-Morton, Thomas J Pohida
BACKGROUND: Naturalistic driving studies, designed to objectively assess driving behavior and outcomes, are conducted by equipping vehicles with dedicated instrumentation (eg, accelerometers, gyroscopes, Global Positioning System, and cameras) that provide continuous recording of acceleration, location, videos, and still images for eventual retrieval and analyses. However, this research is limited by several factors: the cost of equipment installation; management and storage of the large amounts of data collected; and data reduction, coding, and analyses...
April 19, 2018: JMIR MHealth and UHealth
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