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https://www.readbyqxmd.com/read/29593428/can-patient-safety-be-improved-by-reducing-the-volume-of-inappropriate-prescribing-tasks-handed-over-to-out-of-hours-junior-doctors
#1
Samuel Martin Amis, Tobin Henry Edgar Osicki
Background: First-year doctors found that during out-of-hours shifts they were being delayed and distracted from reviewing potentially sick/deteriorating patients by a high volume of prescribing tasks. This predominately consisted of oral anticoagulation prescribing and rewrites of drug charts. We hoped that if we could reduce this burden of "inappropriate prescribing tasks", we could not only improve junior doctors' job satisfaction and opportunities for training but also give them more time for patient reviews...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29588836/emerging-role-of-thalidomide-in-the-treatment-of-gastrointestinal-bleeding
#2
REVIEW
Michael McFarlane, Lauren O'Flynn, Rachel Ventre, Benjamin R Disney
Thalidomide was initially synthesised in 1954 and marketed as a sedative and antiemetic for morning sickness. It was withdrawn in 1961 due to the realisation that it was teratogenic with over 10 000 children born with congenital abnormalities. Since then it has been used for treatment of dermatological and oncological conditions, including myeloma. In 1994, it was found to have a potent antiangiogenic effect via downregulation of vascular endothelial growth factor (VEGF). This has led to its use in gastrointestinal bleeding, as vascular abnormalities such as angiodysplasia have been found to have elevated VEGF levels...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29587423/iodine-and-pregnancy-a-qualitative-study-focusing-on-dietary-guidance-and-information
#3
Maria Bouga, Michael E J Lean, Emilie Combet
Iodine is essential for thyroid hormones synthesis and normal neurodevelopment; however, ~60% of pregnant women do not meet the WHO (World Health Organization) recommended intake. Using a qualitative design, we explored the perceptions, awareness, and experiences of pregnancy nutrition, focusing on iodine. Women in the perinatal period ( n = 48) were interviewed and filled in a food frequency questionnaire for iodine. Almost all participants achieved the recommended 150 μg/day intake for non-pregnant adults (99%), but only 81% met the increased demands of pregnancy (250 μg/day)...
March 26, 2018: Nutrients
https://www.readbyqxmd.com/read/29567688/protein-may-explain-morning-sickness-and-worse
#4
Roni Dengler
No abstract text is available yet for this article.
March 23, 2018: Science
https://www.readbyqxmd.com/read/29357830/nicotine-dependence-in-croatian-male-inpatients-with-schizophrenia
#5
Marina Šagud, Bjanka Vuksan-Ćusa, Nenad Jakšić, Alma Mihaljević-Peleš, Maja Živković, Suzana Vlatković, Tea Prgić, Darko Marčinko, Wei Wang
BACKGROUND: Patients with schizophrenia have the highest known rates of cigarette smoking, but less is known about their smoking behavior and the differences across geographical regions, including Croatia. The aim of this study was to compare patterns of nicotine dependence between patients with schizophrenia and healthy individuals, and to determine the relationship between clinical presentation and the severity of smoking. METHODS: This cross-sectional study included 182 recently hospitalized male inpatients and 280 healthy males, who were daily smokers...
January 22, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29310609/self-medication-among-pregnant-women-attending-antenatal-clinic-at-makongoro-health-centre-in-mwanza-tanzania-a-challenge-to-health-systems
#6
Karol J Marwa, Agnes Njalika, Deodatus Ruganuza, Deogratias Katabalo, Erasmus Kamugisha
BACKGROUND: Self-medication is a universal challenge that requires attention because of the potential threat not only to the pregnant women but also to unborn child. Data on self-medication practice and predictors among pregnant women is lacking in Tanzania. Information on the effects of this practice to the pregnant woman and the foetus globally is also scanty. METHODS: This was a cross sectional study which was conducted using face to face interview with 372 pregnant women at Makongoro health centre...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29278627/what-do-pregnant-women-know-about-harmful-effects-of-medication-and-herbal-remedies-use-during-pregnancy
#7
Tatjana Barišić, Ana Pecirep, Ruža Milićević, Anja Vasilj, Dejan Tirić
BACKGROUND: The objective of this study was assasment of women's knowledge and awareness on medication and herbal remedies use during pregnancy. SUBJECTS AND METHODS: Cross-sectional study was conducted in Department of Obstetrics and Gynaecology University Clinical Hospital Mostar. The study included 230 parturients (primipara) and 20 pharmacists who work in pharmacies of Mostar. Collected and analyzed data was based on a questionnaire of 25 questions. RESULTS: Out of total number of respondents (N =230), 159 of them (69...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29261669/patients-with-mdr-tb-on-domiciliary-care-in-programmatic-settings-in-myanmar-effect-of-a-support-package-on-preventing-early-deaths
#8
Pyae Phyo Wai, Hemant Deepak Shewade, Nang Thu Thu Kyaw, Khine Wut Yee Kyaw, Saw Thein, Aung Si Thu, Myo Minn Oo, Pyae Sone Htwe, Moe Myint Theingi Tun, Htet Myet Win Maung, Kyaw Thu Soe, Si Thu Aung
BACKGROUND: The community-based MDR-TB care (CBMDR-TBC) project was implemented in 2015 by The Union in collaboration with national TB programme (NTP) in 33 townships of upper Myanmar to improve treatment outcomes among patients with MDR-TB registered under NTP. They received community-based support through the project staff, in addition to the routine domiciliary care provided by NTP staff. Each project township had a project nurse exclusively for MDR-TB and a community volunteer who provided evening directly observed therapy (in addition to morning directly observed therapy by NTP)...
2017: PloS One
https://www.readbyqxmd.com/read/29212865/the-placenta-controls-the-physiology-of-pregnancy-by-increasing-the-half-life-in-blood-and-receptor-activity-of-its-secreted-peptide-hormones
#9
REVIEW
Philip Lowry, Russell Woods
An efficient functioning placenta is essential for a healthy pregnancy and yet the way this is achieved has been the subject of much discussion and confusion, particularly with the occurrence of pathological conditions such as preeclampsia, morning sickness and hyperemesis/ptyalism gravidarum. We will attempt to explain the underlying physiology and the potential roles played by the placental tachykinins, neurokinin B and endokinin.
January 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29212864/morning-sickness-is-just-the-side-effect-of-a-new-tachykinin-that-the-placenta-secretes-to-improve-local-blood-flow
#10
Phil Lowry
No abstract text is available yet for this article.
January 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29109034/the-changing-health-of-thalidomide-survivors-as-they-age-a-scoping-review
#11
REVIEW
Elizabeth Newbronner, Karl Atkin
BACKGROUND: In the late 1950s and early 1960s the drug Thalidomide was given to thousands of pregnant women across the world to relieve morning sickness. The drug caused severe birth defects. Much has been written about the drug, its teratogenic effects, and the nature of the damage it caused. There is however, little literature exploring ageing with Thalidomide damage. OBJECTIVES: The aim of the review was to bring together, for the first time, the evidence about the Thalidomide-related health problems Thalidomide survivors are experiencing, as they grow older...
October 28, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29023763/cps49-induced-neurotoxicity-does-not-cause-limb-patterning-anomalies-in-developing-chicken-embryos
#12
Chris Mahony, Scott McMenemy, Alexandra J Rafipay, Shaunna-Leigh Beedie, Lucas Rosa Fraga, Michael Gütschow, William D Figg, Lynda Erskine, Neil Vargesson
Thalidomide notoriously caused severe birth defects, particularly to the limbs, in those exposed in utero following maternal use of the drug to treat morning sickness. How the drug caused these birth defects remains unclear. Many theories have been proposed including actions on the forming blood vessels. However, thalidomide survivors also have altered nerve patterns and the drug is known for its neurotoxic actions in adults following prolonged use. We have previously shown that CPS49, an anti-angiogenic analog of thalidomide, causes a range of limb malformations in a time-sensitive manner in chicken embryos...
October 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28917947/effect-of-meal-glycemic-load-and-caffeine-consumption-on-prolonged-monotonous-driving-performance
#13
Christopher Bragg, Ben Desbrow, Susan Hall, Christopher Irwin
OBJECTIVE: Monotonous driving involves low levels of stimulation and high levels of repetition and is essentially an exercise in sustained attention and vigilance. The aim of this study was to determine the effects of consuming a high or low glycemic load meal on prolonged monotonous driving performance. The effect of consuming caffeine with a high glycemic load meal was also examined. METHOD: Ten healthy, non-diabetic participants (7 males, age 51±7yrs, mean±SD) completed a repeated measures investigation involving 3 experimental trials...
November 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28915867/the-associations-between-workplace-bullying-salivary-cortisol-and-long-term-sickness-absence-a-longitudinal-study
#14
Matias Brødsgaard Grynderup, Kirsten Nabe-Nielsen, Theis Lange, Paul Maurice Conway, Jens Peter Bonde, Anne Helene Garde, Maria Gullander, Linda Kaerlev, Roger Persson, Reiner Rugulies, Marianne Agergaard Vammen, Annie Høgh, Åse Marie Hansen
BACKGROUND: Workplace stressors, such as bullying, are strongly related to subsequent long-term sickness absence, but little is known of the possible physiological mechanisms linking workplace stressors and sickness absence. The primary aim of this study was to investigate to what extent cortisol levels were associated with subsequent sickness absence and if cortisol mediated the association between workplace bullying and sickness absence. We additionally investigated possible bidirectional associations between bullying, cortisol, and long-term sickness absence...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28813267/protective-parenting-neurobiological-and-behavioral-dimensions
#15
REVIEW
Marian J Bakermans-Kranenburg, Marinus H van IJzendoorn
The current review focuses on a dimension of parenting that has largely been neglected in studies on human parenting, namely parental protection. Human protective parenting can be observed already during pregnancy, when mothers experiencing morning sickness avoid foods that are likely to carry pathogens and thus could be harmful to the fetus. After the birth of the baby, one of the foremost anxieties of parents is that their child will be abused or killed by strangers. Protective parenting seems to be a species-wide evolutionary-based behavior complementary to the innate bias of each newborn to strive for proximity to a potentially protective attachment figure...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28800670/-oral-health-and-pregnancy-patient-survey-using-a-questionnaire
#16
Tobias Odermatt, Andreas Schötzau, Irene Hoesli
Introduction and Hypothesis This study investigated how well pregnant patients were informed about the causes and effects of gingivitis during pregnancy. Factors such as age, level of education and nationality were taken into account. Data was collected for the overall oral hygiene of the patients and differences between outpatient and inpatient pregnancies were shown. Possible risk factors in terms of birth results were also defined. Methods With the use of a questionnaire, 83 patients (40 outpatients/43 inpatients) were asked about their oral hygiene, as well as their knowledge pertaining to the causes and effects of gingivitis...
August 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28745489/the-dihydroxy-metabolite-of-the-teratogen-thalidomide-causes-oxidative-dna-damage
#17
Tasaduq H Wani, Anindita Chakrabarty, Norio Shibata, Hiroshi Yamazaki, F Peter Guengerich, Goutam Chowdhury
Thalidomide [α-(N-phthalimido)glutarimide] (1) is a sedative and antiemetic drug originally introduced into the clinic in the 1950s for the treatment of morning sickness. Although marketed as entirely safe, more than 10 000 babies were born with severe birth defects. Thalidomide was banned and subsequently approved for the treatment of multiple myeloma and complications associated with leprosy. Although known for more than 5 decades, the mechanism of teratogenicity remains to be conclusively understood. Various theories have been proposed in the literature including DNA damage and ROS and inhibition of angiogenesis and cereblon...
August 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28716290/yarsagumba-fungus-health-problems-in-the-himalayan-gold-rush
#18
Pranawa Koirala, Bidur Pandit, Pratibha Phuyal, Ken Zafren
INTRODUCTION: Seasonal migration of people in search of Yarsagumba fungus creates a population of collectors that faces hardship and health risks in austere high-altitude settings. METHODS: In 2016, our 4-person team performed a 2-day health-needs survey of people collecting Yarsagumba fungus near the village of Yak Kharka (4020 m) in the Manang District of Nepal. RESULTS: There were approximately 800 people, both male and female, from age 10 to over 60, collecting Yarsagumba fungus...
July 14, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28668540/budesonide-versus-acetazolamide-for-prevention-of-acute-mountain-sickness
#19
Grant S Lipman, David Pomeranz, Patrick Burns, Caleb Phillips, Mary Cheffers, Kristina Evans, Carrie Jurkiewicz, Nick Juul, Peter Hackett
BACKGROUND: Inhaled budesonide has been suggested as a novel prevention for acute mountain sickness. However, efficacy has not been compared with the standard acute mountain sickness prevention medication acetazolamide. METHODS: This double-blind, randomized, placebo-controlled trial compared inhaled budesonide versus oral acetazolamide versus placebo, starting the morning of ascent from 1240 m (4100 ft) to 3810 m (12,570 ft) over 4 hours. The primary outcome was acute mountain sickness incidence (headache and Lake Louise Questionnaire ≥3 and another symptom)...
February 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/28570858/chronological-narratives-from-smoking-initiation-through-to-pregnancy-of-indigenous-australian-women-a-qualitative-study
#20
Gillian S Gould, Michelle Bovill, Marilyn J Clarke, Maree Gruppetta, Yvonne Cadet-James, Billie Bonevski
OBJECTIVE: One in two Indigenous Australian pregnant women smoke, yet little is known about their trajectory of smoking. This study aimed to explore Aboriginal women's narratives from starting smoking through to pregnancy. METHODS: A female Aboriginal Researcher conducted individual face-to-face interviews with 20 Aboriginal women from New South Wales, Australia. Recruitment, through Aboriginal services and community networks, continued until saturation was reached...
May 19, 2017: Midwifery
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