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https://www.readbyqxmd.com/read/28716290/yarsagumba-fungus-health-problems-in-the-himalayan-gold-rush
#1
Pranawa Koirala, Bidur Pandit, Pratibha Phuyal, Ken Zafren
INTRODUCTION: Seasonal migration of people in search of Yarsagumba fungus creates a population of collectors that faces hardship and health risks in austere high-altitude settings. METHODS: In 2016, our 4-person team performed a 2-day health-needs survey of people collecting Yarsagumba fungus near the village of Yak Kharka (4020 m) in the Manang District of Nepal. RESULTS: There were approximately 800 people, both male and female, from age 10 to over 60, collecting Yarsagumba fungus...
July 14, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28668540/a-randomized-controlled-trial-of-budesonide-versus-acetazolamide-for-the-prevention-of-acute-mountain-sickness
#2
Grant S Lipman, David Pomeranz, Patrick Burns, Caleb Phillips, Mary Cheffers, Kristina Evans, Carrie Jurkiewicz, Nick Juul, Peter Hackett
BACKGROUND: Inhaled budesonide has been suggested as a novel prevention for acute mountain sickness. However, efficacy has not been compared to the standard acute mountain sickness prevention medication acetazolamide. METHODS: This double-blind, randomized, placebo-controlled trial compared inhaled budesonide to oral acetazolamide to placebo, starting the morning of ascent from 1,240 m (4,100 ft) to 3,810 m (12,570 ft) over 4 hours. The primary outcome was acute mountain sickness incidence (headache and Lake Louise Questionnaire ≥ 3 and another symptom)...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28570858/chronological-narratives-from-smoking-initiation-through-to-pregnancy-of-indigenous-australian-women-a-qualitative-study
#3
Gillian S Gould, Michelle Bovill, Marilyn J Clarke, Maree Gruppetta, Yvonne Cadet-James, Billie Bonevski
OBJECTIVE: One in two Indigenous Australian pregnant women smoke, yet little is known about their trajectory of smoking. This study aimed to explore Aboriginal women's narratives from starting smoking through to pregnancy. METHODS: A female Aboriginal Researcher conducted individual face-to-face interviews with 20 Aboriginal women from New South Wales, Australia. Recruitment, through Aboriginal services and community networks, continued until saturation was reached...
May 19, 2017: Midwifery
https://www.readbyqxmd.com/read/28551470/epidemiological-profile-of-smoking-and-nicotine-addiction-among-asthmatic-adolescents
#4
F Vázquez-Nava, E M Vázquez-Rodríguez, C F Vázquez-Rodríguez, O Castillo Ruiz, J Peinado Herreros
OBJECTIVE: Despite the harmful effects of cigarette smoking, this habit in asthmatic adolescents continues to be a health problem worldwide. Our objectives were to determine the epidemiological profile of smoking and the degree of nicotine dependence among asthmatic adolescents. STUDY DESIGN: Through a cross-sectional investigation, 3383 adolescents (13-19 years of age) were studied. METHODS: Information was collected using a previously validated questionnaire...
May 25, 2017: Public Health
https://www.readbyqxmd.com/read/28469241/a-hand-to-tbx5-explains-the-link-between-thalidomide-and-cardiac-diseases
#5
Athar Khalil, Rachel Tanos, Nehmé El-Hachem, Mazen Kurban, Patrice Bouvagnet, Fadi Bitar, Georges Nemer
Congenital heart disease is the leading cause of death in the first year of life. Mutations only in few genes have been linked to some cases of CHD. Thalidomide was used by pregnant women for morning sickness but was removed from the market because it caused severe malformations including CHDs. We used both in silico docking software, and in vitro molecular and biochemical methods to document a novel interaction involving Thalidomide, TBX5, and HAND2. Thalidomide binds readily to TBX5 through amino acids R81, R82, and K226 all implicated in DNA binding...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429672/the-molecular-mechanisms-of-thalidomide-teratogenicity-and-implications-for-modern-medicine
#6
J Knobloch, D Jungck, A Koch
Thalidomide is a teratogen that affects many organs but primarily induces limb truncations like phocomelia. Rodents are thalidomide resistant. In the 1950s, this has led to misinterpretations of animal tests and to the fatal assumption that the drug was safe for pregnant women to use against morning sickness. The result was one of the biggest scandals in medical history: 10.000 and more infants with birth defects in Europe. Nonetheless, thalidomide still has its place in modern medicine as it has strong therapeutic potential: it has been approved by the FDA for multiple myeloma and erythema nodosum leprosum, and its anti-inflammatory, immunomodulatory and anti-angiogenic activities are considered in many other refractory diseases...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28398668/-the-legacy-of-thalidomide-a-multidisciplinary-meeting-held-at-the-university-of-york-united-kingdom-on-september-30-2016
#7
Elizabeth Newbronner, Neil Vargesson, Karl Atkin
BACKGROUND: Between 1957 and 1962 thalidomide was used as a nonaddictive, nonbarbiturate sedative that also was successful in relieving the symptoms of morning sickness in early pregnancy. Infamously, thousands of babies were subsequently born with severe birth defects. The drug is used again, today, to successfully treat leprosy, and tragically, there is a new generation of thalidomide damaged children in Brazil. While the outward damage in babies has been documented, the effects of the damage upon the survivors as they grow up, the lifestyle changes and adaptations required to be made, as well as studies into ageing in survivors, has received little attention and remains understudied...
March 1, 2017: Birth defects research
https://www.readbyqxmd.com/read/28370590/normative-data-on-the-diurnal-pattern-of-the-karolinska-sleepiness-scale-ratings-and-its-relation-to-age-sex-work-stress-sleep-quality-and-sickness-absence-illness-in-a-large-sample-of-daytime-workers
#8
Torbjorn Åkerstedt, David Hallvig, Göran Kecklund
Self-rated sleepiness responds to sleep loss, time of day and work schedules. There is, however, a lack of a normative reference showing the diurnal pattern during a normal working day, compared with a day off, as well as differences depending on stress, sleep quality, sex, age and being sick listed. The present study sought to provide such data for the Karolinska Sleepiness Scale. Participants were 431 individuals working in medium-sized public service units. Sleepiness (Karolinska Sleepiness Scale, scale 1-9) was rated at six times a day for a working week and 2 days off (>90...
March 29, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28338555/retinal-detachment-and-retrobulbar-cysts-in-a-large-cohort-of-optic-nerve-coloboma
#9
Yufeng N Chen, C K Patel, Peter J Kertes, Robert G Devenyi, Susan Blaser, Wai-Ching Lam
PURPOSE: To examine the relationship between retinal detachment and retrobulbar cysts in patients with optic nerve coloboma (ONC) and Morning Glory syndrome (MGS). METHODS: Patients diagnosed with either ONC or MGS were identified through a search of the Sick Kids database. Seventy-one patients either agreed to come in for a B-scan or had an incidental orbital B-scan or magnetic resonance imaging or both. Eyes with orbital B-scan ultrasound and/or magnetic resonance imaging images were assessed independently by two ophthalmologists and a radiologist for the presence of retrobulbar cysts...
March 23, 2017: Retina
https://www.readbyqxmd.com/read/28333563/effect-of-high-altitude-exposure-on-intraocular-pressure-using-goldmann-applanation-tonometry
#10
Gabriel Willmann, Kai Schommer, Maximilian Schultheiss, M Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, Andreas Schatz
Willmann, Gabriel, Kai Schommer, Maximilian Schultheiss, M. Dominik Fischer, Karl-Ulrich Bartz-Schmidt, Florian Gekeler, and Andreas Schatz. Effect of high altitude exposure on intraocular pressure using Goldmann applanation tonometry. High Alt Med Biol. 00:000-000, 2017. AIMS: The aim of the study was to quantify changes of intraocular pressure (IOP) during exposure to 4559 m using the state-of-the-art method of Goldmann applanation tonometry for IOP measurement and to detect correlations between IOP and acute mountain sickness (AMS) in a prospective manner...
March 23, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28251400/effects-of-rapid-ascent-on-the-heart-rate-variability-of-individuals-with-and-without-acute-mountain-sickness
#11
Ming Ling Yih, Fang-Chi Lin, Heng-Sheng Chao, Han-Chen Tsai, Shi-Chuan Chang
PURPOSE: Through time- and frequency-domain analysis, we compared the effects of acute hypobaric hypoxia on the changes in heart rate variability (HRV) following night sleeping and morning awakening in individuals with and without acute mountain sickness (AMS). METHOD: Thirty-nine nonacclimatised healthy individuals were transported by bus from sea level to 3150 m within 3 h. Short-term HRV was measured two times a day-before sleeping (BS) and after awakening (AA)- at 3 days before ascent (T0), two consecutive nights at 3150 m (T1 and T2), and 2 days after descent (T3)...
April 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28099781/old-drug-scaffold-new-activity-thalidomide-correlated-compounds-exert-different-effects-on-breast-cancer-cell-growth-and-progression
#12
Domenico Iacopetta, Alessia Carocci, Maria Stefania Sinicropi, Alessia Catalano, Giovanni Lentini, Jessica Ceramella, Rosita Curcio, Maria Cristina Caroleo
Thalidomide was first used for relief of morning sickness in pregnant women and then withdrawn from the market because of its dramatic effects on normal fetal development. Over the last decades, it has been used successfully for the treatment of several pathologies, including cancer. Many analogues with improved activity have been synthesized and tested. Herein we report some effects on the growth and progression of MCF-7 and MDA-MB-231 breast cancer cells by a small series of thalidomide-correlated compounds, which are very effective at inducing cancer cell death by triggering TNFα-mediated apoptosis...
March 7, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28069575/flawed-invisible-trial-underpins-us-morning-sickness-drug-researchers-say
#13
Owen Dyer
No abstract text is available yet for this article.
January 9, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28065259/predictors-of-ramadan-fasting-during-pregnancy
#14
Lily A van Bilsen, Ary I Savitri, Dwirani Amelia, Mohammad Baharuddin, Diederick E Grobbee, Cuno S P M Uiterwaal
Although the health effects of Ramadan fasting during pregnancy are still unclear, it is important to identify the predictors and motivational factors involved in women's decision to observe the fast. We investigated these factors in a cross sectional study of 187 pregnant Muslim women who attended antenatal care visits in the Budi Kemuliaan Hospital, Jakarta, Indonesia. The odds of adherence to fasting were reduced by 4% for every week increase in gestational age during Ramadan [odds ratio (OR) 0.96; 95% confidence interval (CI) 0...
December 2016: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/27941252/antenatal-health-care-and-postnatal-dental-check-ups-prevent-early-childhood-caries
#15
Yukie Nakai, Yukako Mori, Izumi Tamaoka
The first stage of early childhood caries (ECC) is infection by mutans streptococci, of which the primary infection source is the child's mother. Early intervention programs including antenatal and postnatal phases are effective for reducing ECC. This study was conducted to assess the respective effects of antenatal health care and postnatal care such as regular dental check-ups on reducing ECC among 3-year-old Japanese children. This nested case-control study of 155 three-year-old children (49.0% boys) was conducted at a dental clinic that provides collaborative health services with the Obstetrics and Gynecology Clinic, Okayama...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27936110/women-s-perceived-reasons-for-their-excessive-postpartum-weight-retention-a-qualitative-interview-study
#16
Anne Christenson, Eva Johansson, Signy Reynisdottir, Jarl Torgerson, Erik Hemmingsson
INTRODUCTION: Obesity in Sweden has doubled to 14% over the last 20 years. New strategies for treatment and prevention are needed. Excessive gestational weight gain has been found to contribute substantially to obesity, and there is a consistent association between postpartum weight retention and obesity later in life. We aimed to explore what factors women perceive as reasons for having substantial postpartum weight retention, to identify areas for new and improved interventions. METHODS: Qualitative interview study (semi-structured) using an emergent design...
2016: PloS One
https://www.readbyqxmd.com/read/27845881/morning-sickness-of-pregnancy-more-than-meets-the-eye
#17
Noorazizah Arsad, Kah Teik Chew, Nur Azurah Abdul Ghani, Hui Jan Tan, Norasyikin A Wahab, Nor Azlin Mohd Ismail
Wernicke's encephalopathy (WE) is a rare life-threatening complication following severe hyperemesis gravidarum. Early recognition of this condition and prompt thiamine administration is the key to preventing devastating sequelae. We report a successful delivery of a small-for-gestational-age (SGA) baby by a patient with WE and thyrotoxicosis in pregnancy.
November 15, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27692161/a-novel-treatment-for-morning-sickness-nausea-of-pregnancy-could-be-induced-by-excess-sulfite-which-molybdenum-can-help-alleviate
#18
Catherine E Taylor
Nausea and vomiting of pregnancy (NVP) remains difficult to treat. Last century, thalidomide was used to alleviate NVP, but it caused teratogenesis by interfering with angiogenesis. The gasotransmitters hydrogen sulfide (H2S) and nitric oxide are mutually dependent on each other for their angiogenesis-related functions. Pregnancy-related requirements for increased endogenous H2S could create a temporary excess of sulfite, an H2S catabolite, which is toxic and can induce nausea. Sulfite oxidase, a molybdenum-containing enzyme, catalyzes oxidation of sulfite to sulfate, which can then be excreted or reused by the body...
October 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27640135/a-higher-baseline-somatization-score-at-sea-level-as-an-independent-predictor-of-acute-mountain-sickness
#19
Shi-Zhu Bian, Jun Jin, Jun-Qing Dong, Qian-Ning Li, Jie Yu, Cai-Fa Tang, Shi-Yong Yu, Xiao-Hui Zhao, Jun Qin, Lan Huang
OBJECTIVE: The current study aimed to identify the predictive values of psychological factors that are evaluated by the Symptoms Checklist-90 (SCL-90) for acute mountain sickness (AMS). METHODS: The subjects (n=285, non-acclimatized young Chinese men), who were recruited in July 2013, completed a case report questionnaire. In addition, their vital signs (heart rate [HR], blood pressure and pulse oxygen saturation) were measured, and their psychological factors were examined using the SCL-90 at sea level...
December 1, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27599781/importance-of-the-interaction-between-immune-cells-and-tumor-vasculature-mediated-by-thalidomide-in-cancer-treatment-review
#20
REVIEW
Xin Wang, Yanwei Shen, Shuting Li, Meng Lv, Xiaoman Zhang, Jiao Yang, Fan Wang, Jin Yang
Over the past 60 years, thalidomide has metamorphosized from a drug prescribed to treat morning sickness in pregnant women, which was subsequently found to induce birth defects, into a highly effective therapy for treating leprosy and multiple myeloma. Several mechanisms have been proposed to explain the anticancer effects of thalidomide, including antiangiogenic and immunomodulatory activities. At present, evidence suggests that thalidomide may induce vessel maturation. Vascular normalization may be an effective strategy to enhance cancer immunotherapy...
October 2016: International Journal of Molecular Medicine
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