Anders Bue Klein, Pablo Ranea-Robles, Trine Sand Nicolaisen, Claudia Gil, Kornelia Johann, Julia Prats Quesada, Nina Pistoljevic, Kathrine V R Hviid, Line F Olsen, Simone M Offersen, Jorn Wulff Helge, Henriette Svarre-Nielsen, Jaco Bakker, Maximilian Kleinert, Christoffer Clemmensen
Growth differentiation factor 15 (GDF15) is a stress-induced cytokine. Although the exact physiological function of GDF15 is not yet fully comprehended, the significant elevation of circulating GDF15 levels during gestation suggests a potential role for this hormone in pregnancy. This is corroborated by genetic association studies in which GDF15 and the GDF15 receptor, GDNF Family Receptor Alpha Like (GFRAL) have been linked to morning sickness and hyperemesis gravidarum (HG) in humans. Here, we studied GDF15 biology during pregnancy in mice, rats, macaques, and humans...
August 16, 2023: American Journal of Physiology. Endocrinology and Metabolism