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https://www.readbyqxmd.com/read/28099781/old-drug-scaffold-new-activity-thalidomide-correlated-compounds-exerting-different-effects-on-breast-cancer-cell-growth-and-progression
#1
Alessia Carocci, Alessia Catalano, Domenico Iacopetta, Maria Stefania Sinicropi
Thalidomide was firstly used as morning sickness relief in pregnant women and then withdrawn from market because of its dramatic effects on fetal normal development. Over the last decades, it has been successfully used for the care of several pathologies, including cancer. Many analogues with improved activity were synthesized and tested. Herein, we report some effects on MCF-7 and MDA-MB-231 breast cancer cells growth and progression of a small series of thalidomide correlated compounds, very effective in inducing cancer cells death by triggering TNFα-mediated apoptosis...
January 18, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28069575/flawed-invisible-trial-underpins-us-morning-sickness-drug-researchers-say
#2
Owen Dyer
No abstract text is available yet for this article.
January 9, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28065259/predictors-of-ramadan-fasting-during-pregnancy
#3
Lily A van Bilsen, Ary I Savitri, Dwirani Amelia, Mohammad Baharuddin, Diederick E Grobbee, Cuno S P M Uiterwaal
Although the health effects of Ramadan fasting during pregnancy are still unclear, it is important to identify the predictors and motivational factors involved in women's decision to observe the fast. We investigated these factors in a cross sectional study of 187 pregnant Muslim women who attended antenatal care visits in the Budi Kemuliaan Hospital, Jakarta, Indonesia. The odds of adherence to fasting were reduced by 4% for every week increase in gestational age during Ramadan [odds ratio (OR) 0.96; 95% confidence interval (CI) 0...
December 2016: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/27941252/antenatal-health-care-and-postnatal-dental-check-ups-prevent-early-childhood-caries
#4
Yukie Nakai, Yukako Mori, Izumi Tamaoka
The first stage of early childhood caries (ECC) is infection by mutans streptococci, of which the primary infection source is the child's mother. Early intervention programs including antenatal and postnatal phases are effective for reducing ECC. This study was conducted to assess the respective effects of antenatal health care and postnatal care such as regular dental check-ups on reducing ECC among 3-year-old Japanese children. This nested case-control study of 155 three-year-old children (49.0% boys) was conducted at a dental clinic that provides collaborative health services with the Obstetrics and Gynecology Clinic, Okayama...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27936110/women-s-perceived-reasons-for-their-excessive-postpartum-weight-retention-a-qualitative-interview-study
#5
Anne Christenson, Eva Johansson, Signy Reynisdottir, Jarl Torgerson, Erik Hemmingsson
INTRODUCTION: Obesity in Sweden has doubled to 14% over the last 20 years. New strategies for treatment and prevention are needed. Excessive gestational weight gain has been found to contribute substantially to obesity, and there is a consistent association between postpartum weight retention and obesity later in life. We aimed to explore what factors women perceive as reasons for having substantial postpartum weight retention, to identify areas for new and improved interventions. METHODS: Qualitative interview study (semi-structured) using an emergent design...
2016: PloS One
https://www.readbyqxmd.com/read/27845881/morning-sickness-of-pregnancy-more-than-meets-the-eye
#6
Noorazizah Arsad, Kah Teik Chew, Nur Azurah Abdul Ghani, Hui Jan Tan, Norasyikin A Wahab, Nor Azlin Mohd Ismail
Wernicke's encephalopathy (WE) is a rare life-threatening complication following severe hyperemesis gravidarum. Early recognition of this condition and prompt thiamine administration is the key to preventing devastating sequelae. We report a successful delivery of a small-for-gestational-age (SGA) baby by a patient with WE and thyrotoxicosis in pregnancy.
November 15, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27692161/a-novel-treatment-for-morning-sickness-nausea-of-pregnancy-could-be-induced-by-excess-sulfite-which-molybdenum-can-help-alleviate
#7
Catherine E Taylor
Nausea and vomiting of pregnancy (NVP) remains difficult to treat. Last century, thalidomide was used to alleviate NVP, but it caused teratogenesis by interfering with angiogenesis. The gasotransmitters hydrogen sulfide (H2S) and nitric oxide are mutually dependent on each other for their angiogenesis-related functions. Pregnancy-related requirements for increased endogenous H2S could create a temporary excess of sulfite, an H2S catabolite, which is toxic and can induce nausea. Sulfite oxidase, a molybdenum-containing enzyme, catalyzes oxidation of sulfite to sulfate, which can then be excreted or reused by the body...
October 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27640135/a-higher-baseline-somatization-score-at-sea-level-as-an-independent-predictor-of-acute-mountain-sickness
#8
Shi-Zhu Bian, Jun Jin, Jun-Qing Dong, Qian-Ning Li, Jie Yu, Cai-Fa Tang, Shi-Yong Yu, Xiao-Hui Zhao, Jun Qin, Lan Huang
OBJECTIVE: The current study aimed to identify the predictive values of psychological factors that are evaluated by the Symptoms Checklist-90 (SCL-90) for acute mountain sickness (AMS). METHODS: The subjects (n=285, non-acclimatized young Chinese men), who were recruited in July 2013, completed a case report questionnaire. In addition, their vital signs (heart rate [HR], blood pressure and pulse oxygen saturation) were measured, and their psychological factors were examined using the SCL-90 at sea level...
December 1, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27599781/importance-of-the-interaction-between-immune-cells-and-tumor-vasculature-mediated-by-thalidomide-in-cancer-treatment-review
#9
Xin Wang, Yanwei Shen, Shuting Li, Meng Lv, Xiaoman Zhang, Jiao Yang, Fan Wang, Jin Yang
Over the past 60 years, thalidomide has metamorphosized from a drug prescribed to treat morning sickness in pregnant women, which was subsequently found to induce birth defects, into a highly effective therapy for treating leprosy and multiple myeloma. Several mechanisms have been proposed to explain the anticancer effects of thalidomide, including antiangiogenic and immunomodulatory activities. At present, evidence suggests that thalidomide may induce vessel maturation. Vascular normalization may be an effective strategy to enhance cancer immunotherapy...
October 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27593617/effects-of-dietary-nitrate-supplementation-on-symptoms-of-acute-mountain-sickness-and-basic-physiological-responses-in-a-group-of-male-adolescents-during-ascent-to-mount-everest-base-camp
#10
Philip J Hennis, Kay Mitchell, Edward Gilbert-Kawai, Vassiliki Bountziouka, Angie Wade, Martin Feelisch, Michael P Grocott, Daniel S Martin
: The purpose of this study was to investigate the effects of dietary nitrate supplementation, in the form of beetroot juice, on acute mountain sickness (AMS) symptoms and physiological responses, in a group of young males trekking to Mount Everest Base Camp (EBC). Forty healthy male students (mean age (SD): 16 (1) yrs) trekked to EBC over 11 days. Following an overnight fast, each morning participants completed the Lake Louise AMS questionnaire and underwent a series of physiological tests: resting blood pressure as well as resting and exercising heart rate, respiratory rate, and peripheral oxygen saturation...
September 2, 2016: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/27507366/morning-sickness
#11
Erin Dean
Essential facts Eight out of ten pregnant women are affected by nausea and vomiting in pregnancy. It is one of the most common reasons for pregnant women being admitted to hospital. Despite being known as morning sickness, symptoms can occur at any time of the day or night. The severe form of nausea and vomiting in pregnancy, hyperemesis gravidarum, is much rarer and affects up to 3% of pregnant women. For most women, their symptoms improve or disappear by around week 14, although for some it can last longer...
August 10, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27494079/pre-and-perinatal-complications-in-relation-to-tourette-syndrome-and-co-occurring-obsessive-compulsive-disorder-and-attention-deficit-hyperactivity-disorder
#12
Mohamed Abdulkadir, Jay A Tischfield, Robert A King, Thomas V Fernandez, Lawrence W Brown, Keun-Ah Cheon, Barbara J Coffey, Sebastian F T M de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar, Donald L Gilbert, Dorothy E Grice, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young-Shin Kim, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Marieke D Messchendorp, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L Murphy, Thaïra J C Openneer, Kerstin J Plessen, Judith J G Rath, Veit Roessner, Odette Fründt, Eun-Young Shin, Deborah A Sival, Dong-Ho Song, Jungeun Song, Anne-Marie Stolte, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H Zinner, Matthew W State, Gary A Heiman, Pieter J Hoekstra, Andrea Dietrich
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study...
November 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27492707/the-molecular-mechanism-of-thalidomide-analogs-in-hematologic-malignancies
#13
REVIEW
Stefanie Lindner, Jan Krönke
Thalidomide was sold in the 1950s as a sedative and was also used by pregnant women to treat morning sickness. It became notorious for causing severe birth defects and was removed from the market. More than four decades later, thalidomide had a renaissance in the treatment of cancer. Thalidomide and its more potent analogs, lenalidomide and pomalidomide, are nowadays approved treatments for multiple myeloma and myelodysplastic syndrome with deletion of chromosome 5q. In addition, thalidomide and its analogs inhibit release of tumor necrosis factor-α and increase interleukin-2 (IL-2) and interferon-γ release from T cells...
December 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27448657/antenatal-physical-activity-a-qualitative-study-exploring-women-s-experiences-and-the-acceptability-of-antenatal-walking-groups
#14
Sinéad Currie, Cindy Gray, Ashley Shepherd, Rhona J McInnes
BACKGROUND: Regular physical activity (PA) can be beneficial to pregnant women, however, many women do not adhere to current PA guidelines during the antenatal period. Patient and public involvement is essential when designing antenatal PA interventions in order to uncover the reasons for non-adherence and non-engagement with the behaviour, as well as determining what type of intervention would be acceptable. The aim of this research was to explore women's experiences of PA during a recent pregnancy, understand the barriers and determinants of antenatal PA and explore the acceptability of antenatal walking groups for further development...
2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27416619/diuretic-activity-and-toxicity-study-of-the-aqueous-extract-of-cola-nitida-seed-on-markers-of-renal-function-and-electrolytes-in-rats
#15
Mirian Nnemdi Ashibuogwu, Olukayode Isaac Adeosun, Rufus Ojo Akomolafe, Douglas Olaniyi Sanni, Olaoluwa Sesan Olukiran
BackgroundCola nitida is a plant, conventionally used in Africa in the treatment of various ailments such as migraine, morning sickness and indigestion. The aim of the present study was to explore the diuretic activity of the aqueous extract of C. nitida seed (AECONS) and alteration caused by its subchronic administration on the structure and function of the kidney of male Wistar rats. MethodsThe study was divided into diuretic and subchronic studies. Twenty-five male Wistar rats weighing between 140 and 180 g were divided into five groups of five rats each...
December 1, 2016: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/27354807/management-of-chemotherapy-induced-nausea-and-vomiting-by-risk-profile-role-of-netupitant-palonosetron
#16
REVIEW
Vito Lorusso
As recommended by most recent antiemetic guidelines, the optimal prophylaxis of chemotherapy-induced nausea and vomiting (CINV) requires the combination of 5-HT3 receptor antagonist (RA) with an NK1-RA. Moreover, the major predictors of acute and delayed CINV include: young age, female sex, platinum- or anthracycline-based chemotherapy, nondrinker status, emesis in the earlier cycles of chemotherapy, and previous history of motion/morning sickness. Despite improved knowledge of the pathophysiology of CINV and advances in the availability of active antiemetics, an inconsistent compliance with their use has been reported, thereby resulting in suboptimal control of CINV in several cases...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27275887/morning-sickness-drug-is-not-linked-to-increased-risk-of-birth-defects
#17
(no author information available yet)
A new study has found no evidence of a link between anti-nausea drug Zofran, also known as ondansetron, to an increased risk of having a child with birth defects.
June 1, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27265082/my-personal-experiences-at-the-best-medical-center-a-day-in-the-clinic-the-morning
#18
Philip R Cohen, Razelle Kurzrock
Dr. Ida Lystic is a gastroenterologist who trained at the OTHER (Owen T. Henry and Eugene Rutherford) Medical Center, after having completed her MD degree at the prestigious Harvey Medical School (recently renamed the Harvey Provider School). She accepted a faculty position at the BEST (Byron Edwards and Samuel Thompson) Medical Center. Dr. Lystic shares her experiences on a typical morning in gastroenterology clinic. Although her clinic start date was delayed by 2 months after becoming sick following a mandatory flu shot and having to complete more than 70 hours of compliance training modules, she is now familiar with the BEST system...
May 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27263090/prenatal-marijuana-exposure-impacts-executive-functioning-into-young-adulthood-an-fmri-study
#19
REVIEW
Andra M Smith, Ola Mioduszewski, Taylor Hatchard, Aziza Byron-Alhassan, Carley Fall, Peter A Fried
Understanding the potentially harmful long term consequences of prenatal marijuana exposure is important given the increase in number of pregnant women smoking marijuana to relieve morning sickness. Altered executive functioning is one area of research that has suggested negative consequences of prenatal marijuana exposure into adolescence. Investigating if these findings continue into young adulthood and exploring the neural basis of these effects was the purpose of this research. Thirty one young adults (ages 18-22years) from the longitudinal Ottawa Prenatal Prospective Study (OPPS) underwent functional magnetic resonance imaging (fMRI) during four tasks; 1) Visuospatial 2-Back, 2) Go/NoGo, 3) Letter 2-Back and 4) Counting Stroop task...
November 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27246311/a-4-year-old-child-presenting-morning-onset-of-spontaneous-tracheal-rupture-due-to-bronchial-mucous-plug-occlusion-during-the-nighttime-sleep-a-case-report
#20
Raffaella Capasso, Mattia Carbone, Eugenio Rossi, Rosanna Mamone, Raffaele Zeccolini, Alfonso Reginelli, Massimo Zeccolini, Luca Brunese, Antonio Rotondo
BACKGROUND: Coughing is the most efficient mechanism for clearing mucus and fluid secretions from the airways and its reflex can be suppressed by sleep. Spontaneous tracheal ruptures are believed to result from raised intratracheal pressure against a closed glottis, such as for severe coughing. This is the first reported case of tracheal rupture presented on morning awakening after bronchial mucous plug formation during the nighttime sleep because of an ineffective cough reflex. CASE PRESENTATION: An otherwise healthy white 4-year-old child presented morning onset of dyspnea, chest pain and diffuse swelling of the neck...
June 1, 2016: Journal of Medical Case Reports
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