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John Martin

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https://www.readbyqxmd.com/read/29691937/testing-associations-between-cannabis-use-and-subcortical-volumes-in-two-large-population-based-samples
#1
Nathan A Gillespie, Michael C Neale, Timothy C Bates, Lisa T Eyler, Christine Fennema-Notestine, Jasmin Vassileva, Michael J Lyons, Elizabeth C Prom-Wormley, Katie L McMahon, Paul M Thompson, Greig de Zubicaray, Ian B Hickie, John J McGrath, Lachlan T Strike, Miguel E Rentería, Matthew S Panizzon, Nicholas G Martin, Carol E Franz, William S Kremen, Margaret J Wright
BACKGROUND AND AIMS: Disentangling the putative impact of cannabis on brain morphology from other comorbid substance use is critical. After controlling for the effects of nicotine, alcohol and multi-substance use, this study aimed to determine whether frequent cannabis use is associated with significantly smaller subcortical grey matter volumes. DESIGN: Exploratory analyses using mixed linear models, one per region of interest (ROI), were performed whereby individual differences in volume (outcome) at seven subcortical ROIs were regressed onto cannabis and comorbid substance use (predictors)...
April 24, 2018: Addiction
https://www.readbyqxmd.com/read/29691655/loss-of-function-mutations-in-vars-encoding-cytoplasmic-valyl-trna-synthetase-cause-microcephaly-seizures-and-progressive-cerebral-atrophy
#2
Joshi Stephen, Sheela Nampoothiri, Aditi Banerjee, Nathanial J Tolman, Josef Martin Penninger, Ullrich Elling, Chukwuma A Agu, John D Burke, Kalpana Devadathan, Rajesh Kannan, Yan Huang, Peter J Steinbach, Susan A Martinis, William A Gahl, May Christine V Malicdan
Progressive microcephaly and neurodegeneration are genetically heterogenous conditions, largely associated with genes that are essential for the survival of neurons. In this study, we interrogate the genetic etiology of two siblings from a non-consanguineous family with severe early onset of neurological manifestations. Whole exome sequencing identified novel compound heterozygous mutations in VARS that segregated with the proband: a missense (c.3192G>A; p.Met1064Ile) and a splice site mutation (c.1577-2A>G)...
April 24, 2018: Human Genetics
https://www.readbyqxmd.com/read/29691270/combining-high-sensitivity-cardiac-troponin-i-and-cardiac-troponin-t-in-the-early-diagnosis-of-acute-myocardial-infarction
#3
Noreen van der Linden, Karin Wildi, Raphael Twerenbold, John W Pickering, Martin Than, Louise Cullen, Jaimi Greenslade, William Parsonage, Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Maria Rubini Giménez, Lieke J J Klinkenberg, Otto Bekers, Aline Schöni, Dagmar I Keller, Zaid Sabti, Christian Puelacher, Janosch Cupa, Lukas Schumacher, Nikola Kozhuharov, Karin Grimm, Samyut Shrestha, Dayana Flores, Michael Freese, Claudia Stelzig, Ivo Strebel, Òscar Miró, Katharina Rentsch, Beata Morawiec, Damian Kawecki, Wanda Kloos, Jens Lohrmann, A Mark Richards, Richard Troughton, Christopher Pemberton, Stefan Osswald, Marja P van Dieijen-Visser, Alma M Mingels, Tobias Reichlin, Steven J R Meex, Christian Mueller
Background -Combining two signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction (AMI) with a single blood draw. We aimed to evaluate the diagnostic performance of combinations of high sensitivity (hs) cTnI and hs-cTnT for the early diagnosis of AMI. Methods -The diagnostic performance of combining hs-cTnI (Architect, Abbott) and hs-cTnT (Elecsys, Roche) concentrations (sum, product, ratio and a combination algorithm) obtained at the time of presentation was evaluated in a large multicenter diagnostic study of patients with suspected AMI...
April 24, 2018: Circulation
https://www.readbyqxmd.com/read/29690278/remarkable-fly-diptera-diversity-in-a-patch-of-costa-rican-cloud-forest-why-inventory-is-a-vital-science
#4
Art Borkent, Brian V Brown, Peter H Adler, Dalton de Souza Amorim, Kevin Barber, Daniel Bickel, Stephanie Boucher, Scott E Brooks, John Burger, Z L Burington, Renato S Capellari, Daniel N R Costa, Jeffrey M Cumming, Greg Curler, Carl W Dick, J H Epler, Eric Fisher, Stephen D Gaimari, Jon Gelhaus, David A Grimaldi, John Hash, Martin Hauser, Heikki Hippa, Sergio IbÁÑez-Bernal, Mathias Jaschhof, Elena P Kameneva, Peter H Kerr, Valery Korneyev, Cheslavo A Korytkowski, Giar-Ann Kung, Gunnar Mikalsen Kvifte, Owen Lonsdale, Stephen A Marshall, Wayne N Mathis, Verner Michelsen, Stefan Naglis, Allen L Norrbom, Steven Paiero, Thomas Pape, Alessandre Pereira-Colavite, Marc Pollet, Sabrina Rochefort, Alessandra Rung, Justin B Runyon, Jade Savage, Vera C Silva, Bradley J Sinclair, Jeffrey H Skevington, John O Iii Stireman, John Swann, Pekka Vilkamaa, Terry Wheeler, Terry Whitworth, Maria Wong, D Monty Wood, Norman Woodley, Tiffany Yau, Thomas J Zavortink, Manuel A Zumbado
Study of all flies (Diptera) collected for one year from a four-hectare (150 x 266 meter) patch of cloud forest at 1,600 meters above sea level at Zurquí de Moravia, San José Province, Costa Rica (hereafter referred to as Zurquí), revealed an astounding 4,332 species. This amounts to more than half the number of named species of flies for all of Central America. Specimens were collected with two Malaise traps running continuously and with a wide array of supplementary collecting methods for three days of each month...
March 27, 2018: Zootaxa
https://www.readbyqxmd.com/read/29687887/quantification-of-free-sugars-fructan-pungency-and-sweetness-indices-in-onion-populations-by-ft-mir-spectroscopy
#5
Christopher J Clark, Martin L Shaw, Kathryn M Wright, John A McCallum
BACKGROUND: To facilitate faster phenotyping of onions (Allium cepa L.), Fourier-transform mid infrared (FT-MIR) spectroscopy with partial least squares (PLS) regression modelling was evaluated for determination of pungency (pyruvate), sweetness (free sugars) and fructan in juice samples (n = 605) expressed from bulbs from breeding populations. RESULTS: FTIR spectra (1700-900 cm-1 range) were from 30 μL droplets of unprocessed juice. Goodness-of-fit (R2 ) and prediction errors (SECV) for optimal PLS models were: soluble solids (0...
April 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29686742/time-to-exhale-additional-value-of-expiratory-chest-ct-in-chronic-obstructive-pulmonary-disease
#6
Joshua Gawlitza, Frederik Trinkmann, Hans Scheffel, Andreas Fischer, John W Nance, Claudia Henzler, Nils Vogler, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Stefan O Schoenberg, Thomas Henzler
Objectives: Diagnostic guidelines for chronic obstructive pulmonary disease (COPD) are based on spirometry and clinical criteria. However, this does not address the pathophysiological complexity of the disease sufficiently. Until now, inspiratory chest computed tomography (CT) has been considered as the preferred imaging method in these patients. We hypothesized that expiratory CT may be superior to demonstrate pathophysiological changes. The aim of this prospective study was to systematically compare lung function tests with quantified CT parameters in inspiration and expiration...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29686725/prospective-observational-study-on-acute-appendicitis-worldwide-posaw
#7
Massimo Sartelli, Gian L Baiocchi, Salomone Di Saverio, Francesco Ferrara, Francesco M Labricciosa, Luca Ansaloni, Federico Coccolini, Deepak Vijayan, Ashraf Abbas, Hariscine K Abongwa, John Agboola, Adamu Ahmed, Lali Akhmeteli, Nezih Akkapulu, Seckin Akkucuk, Fatih Altintoprak, Aurelia L Andreiev, Dimitrios Anyfantakis, Boiko Atanasov, Miklosh Bala, Dimitrios Balalis, Oussama Baraket, Giovanni Bellanova, Marcelo Beltran, Renato Bessa Melo, Roberto Bini, Konstantinos Bouliaris, Daniele Brunelli, Adrian Castillo, Marco Catani, Asri Che Jusoh, Alain Chichom-Mefire, Gianfranco Cocorullo, Raul Coimbra, Elif Colak, Silvia Costa, Koray Das, Samir Delibegovic, Zaza Demetrashvili, Isidoro Di Carlo, Nadezda Kiseleva, Tamer El Zalabany, Mario Faro, Margarida Ferreira, Gustavo P Fraga, Mahir Gachabayov, Wagih M Ghnnam, Teresa Giménez Maurel, Georgios Gkiokas, Carlos A Gomes, Ewen Griffiths, Ali Guner, Sanjay Gupta, Andreas Hecker, Elcio S Hirano, Adrien Hodonou, Martin Hutan, Orestis Ioannidis, Arda Isik, Georgy Ivakhov, Sumita Jain, Mantas Jokubauskas, Aleksandar Karamarkovic, Saila Kauhanen, Robin Kaushik, Alfie Kavalakat, Jakub Kenig, Vladimir Khokha, Desmond Khor, Dennis Kim, Jae I Kim, Victor Kong, Konstantinos Lasithiotakis, Pedro Leão, Miguel Leon, Andrey Litvin, Varut Lohsiriwat, Eudaldo López-Tomassetti Fernandez, Eftychios Lostoridis, James Maciel, Piotr Major, Ana Dimova, Dimitrios Manatakis, Athanasio Marinis, Aleix Martinez-Perez, Sanjay Marwah, Michael McFarlane, Cristian Mesina, Michał Pędziwiatr, Nickos Michalopoulos, Evangelos Misiakos, Ali Mohamedahmed, Radu Moldovanu, Giulia Montori, Raghuveer Mysore Narayana, Ionut Negoi, Ioannis Nikolopoulos, Giuseppe Novelli, Viktors Novikovs, Iyiade Olaoye, Abdelkarim Omari, Carlos A Ordoñez, Mouaqit Ouadii, Zeynep Ozkan, Ajay Pal, Gian M Palini, Lars I Partecke, Francesco Pata, Michał Pędziwiatr, Gerson A Pereira Júnior, Tadeja Pintar, Magdalena Pisarska, Cesar F Ploneda-Valencia, Konstantinos Pouggouras, Vinod Prabhu, Padmakumar Ramakrishnapillai, Jean-Marc Regimbeau, Marianne Reitz, Daniel Rios-Cruz, Sten Saar, Boris Sakakushev, Charalampos Seretis, Alexander Sazhin, Vishal Shelat, Matej Skrovina, Dmitry Smirnov, Charalampos Spyropoulos, Marcin Strzałka, Peep Talving, Ricardo A Teixeira Gonsaga, George Theobald, Gia Tomadze, Myftar Torba, Cristian Tranà, Jan Ulrych, Mustafa Y Uzunoğlu, Alin Vasilescu, Savino Occhionorelli, Aurélien Venara, Andras Vereczkei, Nereo Vettoretto, Nutu Vlad, Maciej Walędziak, Tonguç U Yilmaz, Kuo-Ching Yuan, Cui Yunfeng, Justas Zilinskas, Gérard Grelpois, Fausto Catena
Background: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments. Methods: This prospective multicenter observational study was performed in 116 worldwide surgical departments from 44 countries over a 6-month period (April 1, 2016-September 30, 2016)...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29686391/tau-internalization-is-regulated-by-6-o-sulfation-on-heparan-sulfate-proteoglycans-hspgs
#8
Jennifer N Rauch, John J Chen, Alexander W Sorum, Gregory M Miller, Tal Sharf, Stephanie K See, Linda C Hsieh-Wilson, Martin Kampmann, Kenneth S Kosik
The misfolding and accumulation of tau protein into intracellular aggregates known as neurofibrillary tangles is a pathological hallmark of neurodegenerative diseases such as Alzheimer's disease. However, while tau propagation is a known marker for disease progression, exactly how tau propagates from one cell to another and what mechanisms govern this spread are still unclear. Here, we report that cellular internalization of tau is regulated by quaternary structure and have developed a cellular assay to screen for genetic modulators of tau uptake...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29686256/passive-limb-movement-intervals-results-in-repeated-hyperemic-responses-in-those-with-paraplegia
#9
Keith J Burns, Brandon S Pollock, Jon Stavres, Martin Kilbane, Amber Brochetti, John McDaniel
STUDY DESIGN: Repeated measures. OBJECTIVES: Reports suggest passive limb movement (PLM) could be used as a therapy to increase blood flow and tissue perfusion in the paralyzed lower limbs of those with spinal cord injuries. However, the hyperemic response to PLM appears to be transient, lasting only 30-45 s despite continued limb movement. The purpose of this investigation was to determine whether the hyperemic response is repeatable across multiple short bouts of passive limb movement...
April 23, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29684363/immunolabeling-of-cleared-human-pancreata-provides-insights-into-three-dimensional-pancreatic-anatomy-and-pathology
#10
Michaël Noë, Neda Rezaee, Kaushal Asrani, Michael Skaro, Vincent P Groot, Pei-Hsun Wu, Matthew T Olson, Seung-Mo Hong, Sung Joo Kim, Matthew J Weiss, Christopher L Wolfgang, Martin A Makary, Jin He, John L Cameron, Denis Wirtz, Nicholas J Roberts, G Johan A Offerhaus, Lodewijk A A Brosens, Laura D Wood, Ralph H Hruban
Visualizing pathologies in three dimensions (3D) can provide unique insights into the biology of human diseases. A rapid and easy-to-implement dibenzyl ether-based technique was used to clear thick sections of surgically resected human pancreatic parenchyma. Protocols were applicable to both fresh and formalin-fixed paraffin-embedded tissue. The penetration of antibodies into dense pancreatic parenchyma was optimized using both gradually increasing antibody concentrations and centrifugal flow. Immunolabeling with antibodies against CK19 was visualized using both light sheet and confocal laser scanning microscopy...
April 20, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29683424/stochastic-processes-constrain-the-within-and-between-host-evolution-of-influenza-virus
#11
John T McCrone, Robert J Woods, Emily T Martin, Ryan E Malosh, Arnold S Monto, Adam S Lauring
The evolutionary dynamics of influenza virus ultimately derive from processes that take place within and between infected individuals. Here we define influenza virus dynamics in human hosts through sequencing of 249 specimens from 200 individuals collected over 6290 person-seasons of observation. Because these viruses were collected from individuals in a prospective community-based cohort, they are broadly representative of natural infections with seasonal viruses. Consistent with a neutral model of evolution, sequence data from 49 serially sampled individuals illustrated the dynamic turnover of synonymous and nonsynonymous single nucleotide variants and provided little evidence for positive selection of antigenic variants...
April 23, 2018: ELife
https://www.readbyqxmd.com/read/29680099/sustained-3-year-benefits-in-quality-of-life-after-percutaneous-coronary-interventions-in-the-elderly-a-prospective-cohort-study
#12
Bryan P Yan, Lally L Y Chan, Vivian W Y Lee, Cheuk-Man Yu, Martin C S Wong, John Sanderson, Christopher M Reid
BACKGROUND: Impact of percutaneous coronary interventions (PCI) on health-related quality of life (HRQOL) is important but under-reported in elderly patients. OBJECTIVES: To evaluate long-term health status in elderly patients who underwent PCI. METHODS: Consecutive patients who underwent PCI at a university-affiliated hospital from September 2009 to June 2012 were prospectively enrolled with HRQOL assessment at baseline (up to 2 weeks before PCI) and at 6-, 12-, and 36-month follow-up using the EuroQol five-dimensional questionnaire descriptive profile and visual analogue scale (VAS)...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29677511/an-integrated-genome-wide-crispra-approach-to-functionalize-lncrnas-in-drug-resistance
#13
Assaf C Bester, Jonathan D Lee, Alejandro Chavez, Yu-Ru Lee, Daphna Nachmani, Suhani Vora, Joshua Victor, Martin Sauvageau, Emanuele Monteleone, John L Rinn, Paolo Provero, George M Church, John G Clohessy, Pier Paolo Pandolfi
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia (AML), we developed a comprehensive and integrated genome-wide platform based on a dual protein-coding and non-coding integrated CRISPRa screening (DICaS). Putative resistance genes were initially identified using pharmacogenetic data from 760 human pan-cancer cell lines. Subsequently, genome scale functional characterization of both coding and long non-coding RNA (lncRNA) genes by CRISPR activation was performed...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29673507/pre-angioplasty-instantaneous-wave-free-ratio-pullback-predicts-hemodynamic-outcome-in-humans-with-coronary-artery-disease-primary-results-of-the-international-multicenter-ifr-gradient-registry
#14
Yuetsu Kikuta, Christopher M Cook, Andrew S P Sharp, Pablo Salinas, Yoshiaki Kawase, Yasutsugu Shiono, Alessandra Giavarini, Masafumi Nakayama, Salvatore De Rosa, Sayan Sen, Sukhjinder S Nijjer, Rasha Al-Lamee, Ricardo Petraco, Iqbal S Malik, Ghada W Mikhail, Raffi R Kaprielian, Gilbert W M Wijntjens, Shinsuke Mori, Arata Hagikura, Martin Mates, Atsushi Mizuno, Farrel Hellig, Kelvin Lee, Luc Janssens, Kazunori Horie, Shah Mohdnazri, Raul Herrera, Florian Krackhardt, Masahiro Yamawaki, John Davies, Hideo Takebayashi, Thomas Keeble, Seiichi Haruta, Flavio Ribichini, Ciro Indolfi, Jamil Mayet, Darrel P Francis, Jan J Piek, Carlo Di Mario, Javier Escaned, Hitoshi Matsuo, Justin E Davies
OBJECTIVES: The authors sought to evaluate the accuracy of instantaneous wave-Free Ratio (iFR) pullback measurements to predict post-percutaneous coronary intervention (PCI) physiological outcomes, and to quantify how often iFR pullback alters PCI strategy in real-world clinical settings. BACKGROUND: In tandem and diffuse disease, offline analysis of continuous iFR pullback measurement has previously been demonstrated to accurately predict the physiological outcome of revascularization...
April 23, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29669739/tissue-stiffening-promotes-keratinocyte-proliferation-via-activation-of-epidermal-growth-factor-signaling
#15
Fiona N Kenny, Zoe Drymoussi, Robin Delaine-Smith, Alexander P Kao, Ana Catarina Laly, Martin M Knight, Michael P Philpott, John T Connelly
Tissue biomechanics regulate a wide range of cellular functions, but the influences on epidermal homeostasis and repair remain unclear. Here, we examined the role of extracellular matrix stiffness on human keratinocyte behavior using elastomeric substrates with defined mechanical properties. Increased matrix stiffness beyond normal physiologic levels promoted keratinocyte proliferation but did not alter the ability to self-renew or terminally differentiate. Activation of epidermal growth factor (EGF) signaling mediated the proliferative response to matrix stiffness and depended on focal adhesion assembly and cytoskeletal tension...
April 18, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29668508/ultrasound-and-plastic-surgery-clinical-applications-of-the-newest-technology
#16
John P Miller, Martin J Carney, Soobin Lim, John T Lindsey
BACKGROUND: Color Doppler ultrasound (CDUS) has not been routinely used in plastic and reconstructive surgery. Barriers to use have included large, cumbersome equipment, low-definition images, cost, and availability. In addition, programs in plastic surgery have not included training with ultrasound (US); thus, many current-day practitioners are unfamiliar with and reluctant to use this technology. Nevertheless, recent studies have demonstrated the utility of US in surgical planning. With the miniaturization, clearer imaging, and decreased costs of the latest US technology, previous barriers to use have largely been eliminated...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29668267/quantitation-of-endogenous-metabolites-in-mouse-tumors-using-mass-spectrometry-imaging
#17
John G Swales, Alex Dexter, Gregory Hamm, Anna Nilsson, Nicole Strittmatter, Filippos Michopoulos, Christopher Hardy, Pablo Morentin-Gutierrez, Martine Mellor, Per E Andren, Malcolm R Clench, Josephine Bunch, Susan E Critchlow, Richard J A Goodwin
Described is quantitative mass spectrometry imaging (qMSI) methodology for the analysis of lactate and glutamate distributions to delineate heterogeneity between mouse tumor models used to support drug discovery efficacy testing. We evaluate and report on the pre-analysis stabilization methods aimed at improving reproducibility and efficiency of quantitative assessment of endogenous molecules in tissues. Stability experiments demonstrate that optimum stabilization protocols consists of frozen tissue embedding, post tissue-sectioning desiccation and storage of tissue sections at -80°C sealed in vacuum tight containers...
April 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29666135/study-protocol-for-the-saron-trial-a-multicentre-randomised-controlled-phase-iii-trial-comparing-the-addition-of-stereotactic-ablative-radiotherapy-and-radical-radiotherapy-with-standard-chemotherapy-alone-for-oligometastatic-non-small-cell-lung-cancer
#18
John Conibear, Brendan Chia, Yenting Ngai, Andrew Tom Bates, Nicholas Counsell, Rushil Patel, David Eaton, Corinne Faivre-Finn, John Fenwick, Martin Forster, Gerard G Hanna, Susan Harden, Philip Mayles, Syed Moinuddin, David Landau
INTRODUCTION: Following growing evidence to support the safety, local control (LC) and potential improvement in overall survival (OS) in patients with oligometastatic non-small cell lung cancer (NSCLC) that have been treated with local ablative therapy such as stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS), we initiate the SARON trial to investigate the impact and feasibility of adding SABR/SRS and radical radiotherapy (RRT) following standard chemotherapy on OS...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29666044/capturing-ultraviolet-radiation-exposure-and-physical-activity-feasibility-study-and-comparison-between-self-reports-mobile-apps-dosimeters-and-accelerometers
#19
Elke Hacker, Caitlin Horsham, Martin Allen, Andrea Nathan, John Lowe, Monika Janda
BACKGROUND: Skin cancer is the most prevalent cancer in Australia. Skin cancer prevention programs aim to reduce sun exposure and increase sun protection behaviors. Effectiveness is usually assessed through self-report. OBJECTIVE: It was the aim of this study to test the acceptance and validity of a newly developed ultraviolet radiation (UVR) exposure app, designed to reduce the data collection burden to research participants. Physical activity data was collected because a strong focus on sun avoidance may result in unhealthy reductions in physical activity...
April 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29664891/reinventing-the-wheel-impact-of-prolonged-antibiotic-exposure-on-multi-drug-resistant-ventilator-associated-pneumonia-in-trauma-patients
#20
Richard H Lewis, John P Sharpe, Joseph M Swanson, Timothy C Fabian, Martin A Croce, Louis J Magnotti
INTRODUCTION: Multi-drug resistant (MDR) strains of both Acinetobacter baumannii (AB) and Pseudomonas aeruginosa (PA) as causative VAP pathogens are becoming increasingly common. Still, the risk factors associated with this increased resistance have yet to be elucidated. The purpose of this study was to examine the changing sensitivity patterns of these pathogens over time and determine which risk factors predict MDR in trauma patients with VAP. METHODS: Patients with either AB or PA VAP over 10 years were stratified by pathogen sensitivity (sensitive (SEN) and MDR), age, severity of shock and injury severity...
April 16, 2018: Journal of Trauma and Acute Care Surgery
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