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https://www.readbyqxmd.com/read/29662845/suppressive-effects-of-vaccinium-angustifolium-root-extract-via-down-regulation-of-activation-of-syk-lyn-and-nf-%C3%AE%C2%BAb-in-fc%C3%A9-ri-mediated-allergic-reactions
#1
Sun-Yup Shim
Vaccinium angustifolium , reported as the lowbush blueberry, has a rich polyphenolic content with which biological activities have been closely associated. In this study, the effects of V. angustifolium root extract (VAE) on the anti-FcɛRI α chain antibody (CRA-1)-induced FcɛRI-mediated signaling factors, protein tyrosine kinases (PTK), Lyn, Syk, and nuclear factor kappa-B cells (NF-κB) in KU812F cells were investigated. The total phenolic content of VAE was found to be 170±1.9 mg gallic acid equivalents/g...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29609089/comparative-conformational-studies-of-3-4-6-tri-o-acetyl-1-5-anhydro-2-deoxyhex-1-enitols-at-the-dft-level
#2
Andrzej Nowacki, Beata Liberek
B3LYP and M06-2X optimization and MP2 single point calculations are reported for the4 H5 and5 H4 conformations of 3,4,6-tri-O-acetyl-D-allal, 3,4,6-tri-O-acetyl-D-galactal, 3,4,6-tri-O-acetyl-D-glucal, and 3,4,6-tri-O-acetyl-D-gulal. Significant discrepancies in predictions of relative energies and conformers' population for B3LYP and M06-2X optimized geometries are observed. Generally, B3LYP overestimates the conformers' energies with respect to MP2, whereas M06-2X slightly underestimates the conformers' energies...
March 28, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29607148/ventilator-associated-events-after-cardiac-surgery-evidence-from-1-709-patients
#3
Siyi He, Fan Wu, Xiaochen Wu, Mei Xin, Sheng Ding, Jian Wang, Hui Ouyang, Jinbao Zhang
Background: Ventilator-associated event (VAE) is a new surveillance for nosocomial infections in mechanically ventilated patients. To date, little is known about VAEs after cardiac surgeries. The present study firstly focused on patients who have undergone heart operations, intending to draw a comprehensive description of VAEs. Methods: Postoperative patients from September 2012 to December 2015 were monitored for VAEs. By reviewing electronic medical records and preserved files retrospectively, clinical data were further analyzed...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29589410/six-weeks-of-multi-station-program-on-the-knee-proprioception-and-performance-of-futsal-players
#4
Ángel Pérez-Silvestre, Daniel Albert-Lucena, Guido F Gómez-Chiguano, Gustavo Plaza-Manzano, Daniel Pecos-Martín, Tomás Gallego-Izquierdo, Patricia Martín-Casas, Natalia Romero-Franco
BACKGROUND: Proprioception and vertical jump are important parameters in the performance and prevention of injuries in futsal. However, very few studies have analyzed the role of multi-station exercises to improve these variables. The purpose of this study was to assess the effects of a six-week multi-station exercise program on knee joint position sense (JPS) and countermovement jump (CMJ) of futsal players. METHODS: Thirty-four male futsal players randomly classified into experimental (n = 17) or control group (n = 17)...
March 27, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29572885/health-problems-associated-with-irritable-bowel-syndrome-analysis-of-a-primary-care-registry
#5
E Clevers, B Vaes, S Henrard, G Goderis, J Tack, H Törnblom, M Simrén, L Van Oudenhove
BACKGROUND: Associations between irritable bowel syndrome and other health problems have been described, but comprehensive reports are missing, especially in primary care. AIMS: To investigate which health problems are associated with irritable bowel syndrome, how they cluster together and when they are typically diagnosed relative to irritable bowel syndrome. METHODS: We used Intego, a general practice registry in Flanders, Belgium. Patients with an irritable bowel syndrome diagnosis (n = 13 701) were matched with controls without gastrointestinal diagnosis and controls with organic gastrointestinal disease...
March 24, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29551472/the-trauma-life-initiative-the-impact-of-a-multidisciplinary-checklist-process-on-outcomes-and-communication-in-a-trauma-intensive-care-unit
#6
Kimberly Joseph, Sameer Gupta, James Yon, Renee Partida, Lee Cartagena, John Kubasiak, Vanessa Buie, Jared Miller, Dorion Wiley, Kimberly Nagy, Frederic Starr, Andrew Dennis, Matthew Kaminsky, Faran Bokhari
BACKGROUND: Checklists have been advocated to improve quality outcomes/communication in the critical care setting, but results have been mixed. A new checklist process, "TRAUMA LIFE", was implemented in our Trauma Intensive Care Unit (TICU) to replace prior checklists. The purpose of this study was to evaluate the impact of the "TRAUMA LIFE" process implementation on quality metrics and on patient/family communication in the TICU. METHODS: "TRAUMA LIFE" was considered maturely implemented by 2016...
March 9, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29537967/metadata-correction-clinical-validation-of-heart-rate-apps-mixed-methods-evaluation-study
#7
Thijs Vandenberk, Jelle Stans, Christophe Mortelmans, Ruth Van Haelst, Gertjan Van Schelvergem, Caroline Pelckmans, Christophe Jp Smeets, Dorien Lanssens, Hélène De Cannière, Valerie Storms, Inge M Thijs, Bert Vaes, Pieter M Vandervoort
[This corrects the article DOI: 10.2196/mhealth.7254.].
March 14, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29519644/myosteatosis-predicts-survival-after-surgery-for-periampullary-cancer-a-novel-method-using-mri
#8
David P J van Dijk, Frans C H Bakers, Sebastian Sanduleanu, Rianne D W Vaes, Sander S Rensen, Cornelis H C Dejong, Regina G H Beets-Tan, Steven W M Olde Damink
BACKGROUND: Myosteatosis, characterized by inter- and intramyocellular fat deposition, is strongly related to poor overall survival after surgery for periampullary cancer. It is commonly assessed by calculating the muscle radiation attenuation on computed tomography (CT) scans. However, since magnetic resonance imaging (MRI) is replacing CT in routine diagnostic work-up, developing methods based on MRI is important. We developed a new method using MRI-muscle signal intensity to assess myosteatosis and compared it with CT-muscle radiation attenuation...
March 5, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29517177/basilic-vein-transposition-for-unsuitable-upper-arm-hemodialysis-needle-access-segment-may-attenuate-concurrent-hand-ischemia
#9
Michael W M Gerrickens, Roel H D Vaes, Bastiaan Govaert, Joep A W Teijink, Marc R Scheltinga
INTRODUCTION: Some hemodialysis patients with a brachial arteriovenous fistula (AVF) have an unsuitable upper arm needle access segment (NAS) necessitating basilic vein transposition (BVT). It was frequently observed that a portion of these patients spontaneously experienced a warmer and less painful dialysis hand after BVT. Aim of this study was to determine whether BVT for an inadequate NAS attenuated hemodialysis access-induced distal ischemia in patients with a brachial AVF. METHODS: Patients with a brachial AVF and an unsuitable NAS also reporting hand ischemia and scheduled to undergo BVT between 2005 and 2016 in a single facility were studied...
March 8, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29515064/-clinical-characteristics-of-vascular-adverse-events-and-significance-of-peripheral-artery-disease-as-a-risk-factor-in-chronic-myeloid-leukemia-patients-treated-with-nilotinib
#10
Masahiko Sumi, Keijiro Sato, Nozomu Uematsu, Hiroko Kawaguchi, Tsutomu Shishido, Hiroko Kaiume, Wataru Takeda, Takehiko Kirihara, Toshimitsu Ueki, Yuki Hiroshima, Mayumi Ueno, Naoaki Ichikawa, Nobuyuki Urasawa, Hikaru Kobayashi
Vascular adverse events (VAEs) in chronic myeloid leukemia (CML) patients treated with nilotinib (NIL) has become a; however, studies on strategies to prevent VAEs remain limited. Therefore, the present study investigated VAEs in 19 CML patients treated with NIL at our hospital. The median age of the patients was 65 years and median follow-up period was 55 months after the initiation of NIL. VAEs occurred in 8 patients (peripheral artery disease (PAD), n=6; cerebral infarction (CI), n=3; coronary artery disease (CAD), n=4)...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29499423/praying-sitting-position-for-pineal-region-surgery-an-efficient-variant-of-a-classic-positioning-in-neurosurgery
#11
Joham Choque-Velasquez, Roberto Colasanti, Julio C Resendiz-Nieves, Kléber E Gonzáles-Echevarría, Rahul Raj, Behnam Rezai Jahromi, Felix Goehre, Ann-Christine Lindroos, Juha Hernesniemi
OBJECTIVE: Nowadays, the sitting position has lost favor among neurosurgeons partly due to assumptions of increased complications, such as venous air embolisms (VAEs) and hemodynamic disturbances. Moreover, it may oblige the surgeon to a tiring posture. Herein, we describe our protocol for the "praying (steeper sitting) position" for pineal region surgery, a variant which may reduce some of the risks of the sitting position while providing a more ergonomic surgical position...
February 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29475154/nursing-students-and-preceptors-experience-of-assessment-during-clinical-practice-a-multilevel-repeated-interview-study-of-student-preceptor-dyads
#12
Karen Johanne Ugland Vae, Maria Engström, Gunilla Mårtensson, Anna Löfmark
Nursing students' learning process during clinical practice is dependent on the quality of their assessment, and the feedback that is given, however an issue that is very little examined. The aim of this study was to investigate student-preceptor dyads and their experiences of mid-course discussions and final assessment. Data were collected through repeated semi-structured individual interviews with 13 dyads close in time to the assessment discussions, and were analyzed by searching for similarities and differences in their experiences...
November 29, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29453032/impact-of-metformin-on-gastric-adenocarcinoma-survival-a-belgian-population-based-study
#13
Olivia Lacroix, Alexandra Couttenier, Evelien Vaes, Chris R Cardwell, Harlinde De Schutter, Annie Robert
BACKGROUND: Preclinical studies have shown anticancer activities of metformin in gastric cancer and a recent epidemiological study showed a decrease in recurrence and mortality of gastric cancer in metformin users. This study aimed to assess the impact of metformin on gastric cancer survival in diabetic patients at a Belgian population level. METHODS: We conducted an observational, population-based study by linking data of the Belgian Cancer Registry with medical claims data coming from the health insurance companies for patients diagnosed with stage I to III gastric adenocarcinoma between 2006 and 2012...
February 13, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29405647/deep-generative-models-for-molecular-science
#14
REVIEW
Peter B Jørgensen, Mikkel N Schmidt, Ole Winther
Generative deep machine learning models now rival traditional quantum-mechanical computations in predicting properties of new structures, and they come with a significantly lower computational cost, opening new avenues in computational molecular science. In the last few years, a variety of deep generative models have been proposed for modeling molecules, which differ in both their model structure and choice of input features. We review these recent advances within deep generative models for predicting molecular properties, with particular focus on models based on the probabilistic autoencoder (or variational autoencoder, VAE) approach in which the molecular structure is embedded in a latent vector space from which its properties can be predicted and its structure can be restored...
February 6, 2018: Molecular Informatics
https://www.readbyqxmd.com/read/29395362/methods-to-identify-heart-failure-patients-in-general-practice-and-their-impact-on-patient-characteristics-a-systematic-review
#15
Miek Smeets, Séverine Henrard, Bert Aertgeerts, Filip Cools, Stefan Janssens, Bert Vaes
BACKGROUND: Identifying patients with heart failure (HF) in general practice is challenging. Our aim was to provide an overview of methods used to identify patients with HF in general practice and to assess their impact on patient characteristics. METHODS AND RESULTS: A systematic review was conducted using MEDLINE, EMBASE and CENTRAL. Taken together, 105 studies on HF in general practice were included, totalling 196,105 patients. Five main identification methods for HF were distinguished, including 1) echocardiographic assessments, 2) results of echocardiography in general practitioner (GP) charts, 3) GP judgment after chart review, 4) GP judgment of consecutive patients and 5) only chart review...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29382793/frequent-versus-infrequent-monitoring-of-endotracheal-tube-cuff-pressures
#16
Adam Letvin, Pamala Kremer, Patty C Silver, Nizama Samih, Peggy Reed-Watts, Marin H Kollef
BACKGROUND: Currently there is no accepted standard of practice for the optimal frequency of endotracheal tube cuff pressure monitoring in mechanically ventilated patients. Therefore, we conducted a study to compare infrequent endotracheal tube cuff pressure monitoring (immediately after intubation and when clinically indicated for an observed air leak or due to tube migration) with frequent endotracheal tube cuff pressure monitoring (immediately after intubation, every 8 h, and when clinically indicated)...
January 30, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29322987/complications-related-to-sitting-position-during-pediatric-neurosurgery-an-institutional-experience-and-review-of-literature
#17
Priyanka Gupta, Girija P Rath, Hemanshu Prabhakar, Parmod K Bithal
BACKGROUND: Sitting position is preferred during posterior fossa surgeries as it provides better anatomical orientation and a clear surgical field. However, its use has been declining due to its propensity to cause life-threatening complications. This study was carried out to analyze the perioperative complications and postoperative course of children who underwent neurosurgery in sitting position. MATERIALS AND METHODS: Medical records of 97 children (<18 years) who underwent neurosurgery in sitting position over a period of 12 years, were retrospectively analyzed...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29312767/minor-regression-and-long-time-survival-56-months-in-a-patient-with-malignant-pleural-mesothelioma-under-viscum-album-and-helleborus-niger-extracts-a-case-report
#18
Paul G Werthmann, Gerhard Saltzwedel, Gunver S Kienle
Malignant pleural mesothelioma (MPM) is a rare cancer with a dismal prognosis. Viscum album extracts (VAE) have strong immune stimulatory properties, cytotoxic effects, can downregulate cancer genes and inhibit angiogenesis. VAE are often used as an adjunct treatment in cancer patients but have rarely been investigated in MPM. Helleborus niger extracts (HNE) have been used in anticancer therapy since antiquity, and also show tumor specific cytotoxic effects. We present a case of a 64-year old woman with epithelioid MPM of the right chest with node involvement (T2N1M0, stage III)...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29261726/statin-use-is-associated-with-improved-survival-in-ovarian-cancer-a-retrospective-population-based-study
#19
Alexandra Couttenier, Olivia Lacroix, Evelien Vaes, Chris R Cardwell, Harlinde De Schutter, Annie Robert
BACKGROUND: Preclinical in vitro and in vivo studies suggest that statins could exhibit anticancer properties in ovarian cancer. Similar effects have also been reported in observational studies but their results remain inconsistent and could be impaired by methodological limitations. This study aimed to investigate whether statin use is associated with improved survival in ovarian cancer patients at the Belgian population-level. METHODS: All patients with invasive epithelial ovarian cancer diagnosed between 2004 and 2012 were identified from the Belgian Cancer Registry...
2017: PloS One
https://www.readbyqxmd.com/read/29241369/oxygen-saturation-measurements-in-telemonitoring-of-patients-with-copd-a-systematic-review
#20
Joren Buekers, Patrick De Boever, Anouk W Vaes, Jean-Marie Aerts, Emiel F M Wouters, Martijn A Spruit, Jan Theunis
Telemonitoring applications are expected to become a key component in future healthcare. Despite the frequent use of SpO2 measurements in telemonitoring of patients with chronic obstructive pulmonary disease (COPD), no profound overview is available about these measurements. Areas covered: A systematic search identified 71 articles that performed SpO2 measurements in COPD telemonitoring. The results indicate that long-term follow-up of COPD patients using daily SpO2 spot checks is practically feasible. Very few studies specified protocols for performing these measurements...
February 2018: Expert Review of Respiratory Medicine
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