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https://www.readbyqxmd.com/read/29475154/nursing-students-and-preceptors-experience-of-assessment-during-clinical-practice-a-multilevel-repeated-interview-study-of-student-preceptor-dyads
#1
Karen Johanne Ugland Vae, Maria Engström, Gunilla Mårtensson, Anna Löfmark
Nursing students' learning process during clinical practice is dependent on the quality of their assessment, and the feedback that is given, however an issue that is very little examined. The aim of this study was to investigate student-preceptor dyads and their experiences of mid-course discussions and final assessment. Data were collected through repeated semi-structured individual interviews with 13 dyads close in time to the assessment discussions, and were analyzed by searching for similarities and differences in their experiences...
November 29, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/29453032/impact-of-metformin-on-gastric-adenocarcinoma-survival-a-belgian-population-based-study
#2
Olivia Lacroix, Alexandra Couttenier, Evelien Vaes, Chris R Cardwell, Harlinde De Schutter, Annie Robert
BACKGROUND: Preclinical studies have shown anticancer activities of metformin in gastric cancer and a recent epidemiological study showed a decrease in recurrence and mortality of gastric cancer in metformin users. This study aimed to assess the impact of metformin on gastric cancer survival in diabetic patients at a Belgian population level. METHODS: We conducted an observational, population-based study by linking data of the Belgian Cancer Registry with medical claims data coming from the health insurance companies for patients diagnosed with stage I to III gastric adenocarcinoma between 2006 and 2012...
February 13, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29405647/deep-generative-models-for-molecular-science
#3
REVIEW
Peter B Jørgensen, Mikkel N Schmidt, Ole Winther
Generative deep machine learning models now rival traditional quantum-mechanical computations in predicting properties of new structures, and they come with a significantly lower computational cost, opening new avenues in computational molecular science. In the last few years, a variety of deep generative models have been proposed for modeling molecules, which differ in both their model structure and choice of input features. We review these recent advances within deep generative models for predicting molecular properties, with particular focus on models based on the probabilistic autoencoder (or variational autoencoder, VAE) approach in which the molecular structure is embedded in a latent vector space from which its properties can be predicted and its structure can be restored...
February 6, 2018: Molecular Informatics
https://www.readbyqxmd.com/read/29395362/methods-to-identify-heart-failure-patients-in-general-practice-and-their-impact-on-patient-characteristics-a-systematic-review
#4
Miek Smeets, Séverine Henrard, Bert Aertgeerts, Filip Cools, Stefan Janssens, Bert Vaes
BACKGROUND: Identifying patients with heart failure (HF) in general practice is challenging. Our aim was to provide an overview of methods used to identify patients with HF in general practice and to assess their impact on patient characteristics. METHODS AND RESULTS: A systematic review was conducted using MEDLINE, EMBASE and CENTRAL. Taken together, 105 studies on HF in general practice were included, totalling 196,105 patients. Five main identification methods for HF were distinguished, including 1) echocardiographic assessments, 2) results of echocardiography in general practitioner (GP) charts, 3) GP judgment after chart review, 4) GP judgment of consecutive patients and 5) only chart review...
January 30, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29382793/frequent-versus-infrequent-monitoring-of-endotracheal-tube-cuff-pressures
#5
Adam Letvin, Pamala Kremer, Patty C Silver, Nizama Samih, Peggy Reed-Watts, Marin H Kollef
BACKGROUND: Currently there is no accepted standard of practice for the optimal frequency of endotracheal tube cuff pressure monitoring in mechanically ventilated patients. Therefore, we conducted a study to compare infrequent endotracheal tube cuff pressure monitoring (immediately after intubation and when clinically indicated for an observed air leak or due to tube migration) with frequent endotracheal tube cuff pressure monitoring (immediately after intubation, every 8 h, and when clinically indicated)...
January 30, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29322987/complications-related-to-sitting-position-during-pediatric-neurosurgery-an-institutional-experience-and-review-of-literature
#6
Priyanka Gupta, Girija P Rath, Hemanshu Prabhakar, Parmod K Bithal
BACKGROUND: Sitting position is preferred during posterior fossa surgeries as it provides better anatomical orientation and a clear surgical field. However, its use has been declining due to its propensity to cause life-threatening complications. This study was carried out to analyze the perioperative complications and postoperative course of children who underwent neurosurgery in sitting position. MATERIALS AND METHODS: Medical records of 97 children (<18 years) who underwent neurosurgery in sitting position over a period of 12 years, were retrospectively analyzed...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29312767/minor-regression-and-long-time-survival-56-months-in-a-patient-with-malignant-pleural-mesothelioma-under-viscum-album-and-helleborus-niger-extracts-a-case-report
#7
Paul G Werthmann, Gerhard Saltzwedel, Gunver S Kienle
Malignant pleural mesothelioma (MPM) is a rare cancer with a dismal prognosis. Viscum album extracts (VAE) have strong immune stimulatory properties, cytotoxic effects, can downregulate cancer genes and inhibit angiogenesis. VAE are often used as an adjunct treatment in cancer patients but have rarely been investigated in MPM. Helleborus niger extracts (HNE) have been used in anticancer therapy since antiquity, and also show tumor specific cytotoxic effects. We present a case of a 64-year old woman with epithelioid MPM of the right chest with node involvement (T2N1M0, stage III)...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29261726/statin-use-is-associated-with-improved-survival-in-ovarian-cancer-a-retrospective-population-based-study
#8
Alexandra Couttenier, Olivia Lacroix, Evelien Vaes, Chris R Cardwell, Harlinde De Schutter, Annie Robert
BACKGROUND: Preclinical in vitro and in vivo studies suggest that statins could exhibit anticancer properties in ovarian cancer. Similar effects have also been reported in observational studies but their results remain inconsistent and could be impaired by methodological limitations. This study aimed to investigate whether statin use is associated with improved survival in ovarian cancer patients at the Belgian population-level. METHODS: All patients with invasive epithelial ovarian cancer diagnosed between 2004 and 2012 were identified from the Belgian Cancer Registry...
2017: PloS One
https://www.readbyqxmd.com/read/29241369/oxygen-saturation-measurements-in-telemonitoring-of-patients-with-copd-a-systematic-review
#9
Joren Buekers, Patrick De Boever, Anouk W Vaes, Jean-Marie Aerts, Emiel F M Wouters, Martijn A Spruit, Jan Theunis
Telemonitoring applications are expected to become a key component in future healthcare. Despite the frequent use of SpO2 measurements in telemonitoring of patients with chronic obstructive pulmonary disease (COPD), no profound overview is available about these measurements. Areas covered: A systematic search identified 71 articles that performed SpO2 measurements in COPD telemonitoring. The results indicate that long-term follow-up of COPD patients using daily SpO2 spot checks is practically feasible. Very few studies specified protocols for performing these measurements...
December 15, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29241232/thromboelastographic-assessment-of-the-impact-of-mexiletine-on-coagulation-abnormalities-induced-by-air-or-normal-saline-intravenous-injections-in-conscious-rats
#10
Joseph L Nates, Davide Cattano, Fernanda S Costa, Jacques E Chelly, Marie-Francoise Doursout
BACKGROUND: Thromboelastography (TEG) in venous air embolism (VAE) has been poorly studied. We induced coagulation abnormalities by VAE in a rat model, assessed by TEG with and without mexiletine, a lidocaine analogue local anesthetic. METHODS: Twenty-three Sprague Dawley rats instrumented under isoflurane anesthesia and allowed to recover five days prior to the experiments were randomized into three experimental groups: 1) VAE (n = 6); 2) VAE and mexiletine (n = 9); and 3) normal saline (NS) alone (control group, n = 8)...
December 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/29218871/extracting-a-biologically-relevant-latent-space-from-cancer-transcriptomes-with-variational-autoencoders
#11
Gregory P Way, Casey S Greene
The Cancer Genome Atlas (TCGA) has profiled over 10,000 tumors across 33 different cancer-types for many genomic features, including gene expression levels. Gene expression measurements capture substantial information about the state of each tumor. Certain classes of deep neural network models are capable of learning a meaningful latent space. Such a latent space could be used to explore and generate hypothetical gene expression profiles under various types of molecular and genetic perturbation. For example, one might wish to use such a model to predict a tumor's response to specific therapies or to characterize complex gene expression activations existing in differential proportions in different tumors...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29159866/administration-of-adjuvant-chemotherapy-for-stage-ii-iii-colon-cancer-patients-a-european-population-based-study
#12
Masoud Babaei, Yesilda Balavarca, Lina Jansen, Valery Lemmens, Felice N van Erning, Liesbet van Eycken, Evelien Vaes, Annika Sjövall, Bengt Glimelius, Cornelia M Ulrich, Petra Schrotz-King, Hermann Brenner
The advantage of adjuvant chemotherapy (ACT) for treating stage III colon cancer patients is well established and widely accepted. However, many patients with stage III colon cancer do not receive ACT. Moreover, there are controversies around the effectiveness of ACT for stage II patients. We investigated the administration of ACT and its association with overall survival in resected stage II (overall and stratified by low-/high-risk) and stage III colon cancer patients in three European countries including The Netherlands (2009-2014), Belgium (2009-2013), and Sweden (2009-2014)...
November 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29157814/mistletoe-viscum-album-extract-targets-axl-to-suppress-cell-proliferation-and-overcome-cisplatin-and-erlotinib-resistance-in-non-small-cell-lung-cancer-cells
#13
Soyoung Kim, Kyung-Chan Kim, ChuHee Lee
BACKGROUND: Mistletoe extract of Visucm album extract (VAE) contains many biologically active components and has been reported to be not only a complementary and alternative medicine, but also a potent therapeutic agent for many types of cancer. PURPOSE: In this study, we examined the effect of VAE on expression and activation of Axl and scrutinized the involvement of Axl in the anti-cancer activity of VAE in parental and chemo-resistant non-small cell lung cancer (NSCLC) cells...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29154891/acute-pain-perception-during-different-sampling-methods-for-respiratory-culture-in-cystic-fibrosis-patients
#14
Hanneke Eyns, Elke De Wachter, Anne Malfroot, Peter Vaes
BACKGROUND: Reliable identification of lower respiratory tract pathogens is crucial in the management of cystic fibrosis (CF). As part of another study (NCT02363764) investigating the bacterial yield of three sampling methods: nasal swabs (NS), cough swabs (CS) and (induced) sputum samples ((I)SS) in both expectorating (EPs) and non-expectorating (NEPs) patients with CF, the present study aimed to explore the prevalence of respiratory culture sampling-related pain as assessed by self-report within a cohort of children and adults...
November 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29145317/complete-remission-and-long-term-survival-of-a-patient-with-melanoma-metastases-treated-with-high-dose-fever-inducing-viscum-album-extract-a-case-report
#15
Paul G Werthmann, Alexander Hintze, Gunver S Kienle
INTRODUCTION: Metastatic malignant cutaneous melanoma (MCM)-a highly immunogenic cancer-typically has a poor prognosis. Viscum album extracts (VAEs) have strong immune-stimulating, apoptogenic, and cytotoxic effects. CASE PRESENTATION: A 66-year-old MCM patient with newly diagnosed lymph node metastases opted for sole VAE treatment. VAEs were initially applied subcutaneously, and then later in exceptionally high, fever-inducing doses, both intravenously and intralesionally...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29132696/development-and-validation-of-an-automated-ventilator-associated-event-electronic-surveillance-system-a-report-of-a-successful-implementation
#16
Courtney Hebert, Jennifer Flaherty, Justin Smyer, Jing Ding, Julie E Mangino
BACKGROUND: Surveillance is an important tool for infection control; however, this task can often be time-consuming and take away from infection prevention activities. With the increasing availability of comprehensive electronic health records, there is an opportunity to automate these surveillance activities. The objective of this article is to describe the implementation of an electronic algorithm for ventilator-associated events (VAEs) at a large academic medical center METHODS: This article reports on a 6-month manual validation of a dashboard for VAEs...
November 10, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29126595/burn-patients-with-infection-related-ventilator-associated-complications-have-worse-outcomes-compared-to-those-without-ventilator-associated-events
#17
Duraid Younan, Russell Griffin, Ahmed Zaky, Jean-Francois Pittet, Bernard Camins
BACKGROUND: The Centers for Disease Control and Prevention (CDC) replaced its definition for ventilator-associated pneumonia (VAP) in 2013. The aim of the current study is to compare the outcome of burn patients with ventilator associated events (VAEs). METHODS: Burn patients with at least two days of ventilator support were identified from the registry between 2013 and 2016. Kruskal-Wallis and Fisher's exact tests were utilized for continuous and categorical variables, respectively...
October 31, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29058218/ontology-based-vaccine-adverse-event-representation-and-analysis
#18
Jiangan Xie, Yongqun He
Vaccine is the one of the greatest inventions of modern medicine that has contributed most to the relief of human misery and the exciting increase in life expectancy. In 1796, an English country physician, Edward Jenner, discovered that inoculating mankind with cowpox can protect them from smallpox (Riedel S, Edward Jenner and the history of smallpox and vaccination. Proceedings (Baylor University. Medical Center) 18(1):21, 2005). Based on the vaccination worldwide, we finally succeeded in the eradication of smallpox in 1977 (Henderson, Vaccine 29:D7-D9, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046215/prospective-surveillance-of-device-associated-health-care-associated-infection-in-an-intensive-care-unit-of-a-tertiary-care-hospital-in-new-delhi-india
#19
Shilpee Kumar, Poornima Sen, Rajni Gaind, Pardeep Kumar Verma, Poonam Gupta, Prem Rose Suri, Sunita Nagpal, Anil Kumar Rai
BACKGROUND: Surveillance of health care-associated infections (HAIs) plays a key role in the hospital infection control program and reduction of HAIs. In India, most of the surveillance of HAIs is reported from private sector hospitals that do not depict the situation of government sector hospitals. Other studies do not confirm with the Centers for Disease Control and Prevention's (CDC) National Healthcare Safety Network (NHSN) surveillance criterion, or deal with ventilator-associated pneumonia (VAP) instead of ventilator-associated event (VAE)...
October 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29031787/assessing-prediction-accuracy-for-outcomes-of-ventilator-associated-events-and-infections-in-critically-ill-children-a-prospective-cohort-study
#20
Y Peña-López, M Pujol, M Campins, L Lagunes, J Balcells, J Rello
OBJECTIVES: To assess the prediction accuracy of the 2008 US Centers for Disease Control and Prevention (CDC) definitions for ventilator-associated pneumonia (VAP)/ventilator-associated tracheobronchitis (VAT), 2013 CDC definitions for ventilator-associated events (VAE) and a new VAE algorithm in the paediatric (Ped) population, the Ped-VAE. METHODS: We performed a prospective 13-month cohort study at a multidisciplinary paediatric intensive care unit (PICU). Primary endpoints were duration of ventilation episode, PICU or hospitalization length of stay from episode and episode mortality...
October 12, 2017: Clinical Microbiology and Infection
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