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A M M Vaes, E M Brouwer-Brolsma, N L van der Zwaluw, J P van Wijngaarden, A A M Berendsen, N van Schoor, N van der Velde, A Uitterlinden, P Lips, R A M Dhonukshe-Rutten, L C P G M de Groot
Various populations are at increased risk of developing a low vitamin D status, in particular older adults. Whereas sun exposure is considered the main source of vitamin D, especially during summer, dietary contributions should not be underestimated. This study aims to identify food sources of vitamin D that associate most strongly with serum vitamin D concentration. Data of 595 Dutch adults, aged ≥65 years, were analysed. Vitamin D intake was assessed with a food frequency questionnaire and 25-hydroxyvitamin D (25(OH)D) was determined in serum...
October 21, 2016: Journal of Steroid Biochemistry and Molecular Biology
Yunzhou Fan, Fang Gao, Yanyan Wu, Jie Zhang, Ming Zhu, Lijuan Xiong
BACKGROUND: Ventilator-associated event (VAE) is a new surveillance paradigm for monitoring complications in mechanically ventilated patients in intensive care units (ICUs). The National Healthcare Safety Network replaced traditional ventilator-associated pneumonia (VAP) surveillance with VAE surveillance in 2013. The objective of this study was to assess the consistency between VAE surveillance and traditional VAP surveillance. METHODS: We systematically searched electronic reference databases for articles describing VAE and VAP in ICUs...
October 24, 2016: Critical Care: the Official Journal of the Critical Care Forum
Eralda Hegendörfer, Bert Vaes, Elena Andreeva, Catharina Matheï, Gijs Van Pottelbergh, Jean-Marie Degryse
OBJECTIVES: Forced expiratory volume in 1 second (FEV1) is proposed as a marker of healthy ageing and FEV1 expressions that are independent of reference values have been reported to be better at predicting mortality in older adults. We assess and compare the predictive value of different FEV1 expressions for mortality, hospitalization, and physical and mental decline in adults aged 80 and older. DESIGN: Population-based, prospective, cohort study. SETTING: The BELFRAIL study, Belgium...
October 14, 2016: Journal of the American Medical Directors Association
Mathijs C Goossens, Isabel De Brabander, Jacques De Greve, Evelien Vaes, Chantal Van Ongeval, Koen Van Herck, Eliane Kellen
A small number of studies have investigated breast cancer (BC) risk among women with a history of false-positive recall (FPR) in BC screening, but none of them has used time-to-event analysis while at the same time quantifying the effect of false-negative diagnostic assessment (FNDA). FNDA occurs when screening detects BC, but this BC is missed on diagnostic assessment (DA). As a result of FNDA, screenings that detected cancer are incorrectly classified as FPR. Our study linked data recorded in the Flemish BC screening program (women aged 50-69 years) to data from the national cancer registry...
October 4, 2016: European Journal of Cancer Prevention
Ayala Gover-Proaktor, Galit Granot, Saar Shapira, Oshrat Raz, Oren Pasvolsky, Arnon Nagler, Dorit L Lev, Aida Inbal, Ido Lubin, Pia Raanani, Avi Leader
Tyrosine kinase inhibitors (TKIs) have revolutionized the prognosis of chronic myeloid leukemia. With the advent of highly efficacious therapy, the focus has shifted toward managing TKI adverse effects, such as vascular adverse events (VAEs). We used an in vitro angiogenesis model to investigate the TKI-associated VAEs. Our data show that imatinib, nilotinib, and ponatinib reduce human umbilical vein endothelial cells (HUVECs) viability. Pharmacological concentrations of ponatinib induced apoptosis, reduced migration, inhibited tube formation of HUVECs, and had a negative effect on endothelial progenitor cell (EPC) function...
October 12, 2016: Leukemia & Lymphoma
João Paulo M C M Cunha, Gunter Leuckx, Peter Sterkendries, Hannelie Korf, Gabriela Bomfim-Ferreira, Lutgart Overbergh, Bart Vaes, Harry Heimberg, Conny Gysemans, Chantal Mathieu
AIMS/HYPOTHESIS: Hypoxia in the initial days after islet transplantation leads to considerable loss of islet mass and contributes to disappointing outcomes in the clinical setting. The aim of the present study was to investigate whether co-transplantation of human non-endothelial bone marrow-derived multipotent adult progenitor cells (MAPCs), which are non-immunogenic and can secrete angiogenic growth factors during the initial days after implantation, could improve islet engraftment and survival...
October 4, 2016: Diabetologia
John C O'Horo, Haitao Lan, Charat Thongprayoon, Louis Schenck, Adil Ahmed, Mikhail Dziadzko
OBJECTIVE Ventilator-associated events (VAEs) are nosocomial events correlated with length of stay, costs, and mortality. Current ventilator bundle practices target the older definition of ventilator-associated pneumonia and have not been systematically evaluated for their impact on VAEs. DESIGN Retrospective cohort study. SETTING Tertiary medical center between January 2012 and August 2014. PARTICIPANTS All adult patients ventilated for at least 24 hours at our institution. INTERVENTIONS We conducted univariate analyses for compliance with each element; we focused on VAEs occurring within a 2-day window of failure to meet any ventilator bundle element...
September 19, 2016: Infection Control and Hospital Epidemiology
Richard Pugh, Wendy Harrison, Susan Harris, Hywel Roberts, Gareth Scholey, Tamas Szakmany
INTRODUCTION: The reported incidence of ventilator-associated pneumonia (VAP) in Wales is low compared with surveillance data from other European regions. It is unclear whether this reflects success of the Welsh healthcare-associated infection prevention measures or limitations in the application of European VAP surveillance methods. Our primary aim was to investigate episodes of ventilator-associated respiratory tract infection (VARTI), to identify episodes that met established criteria for VAP, and to explore reasons why others did not, according to the Hospitals in Europe Link for Infection Control through Surveillance (HELICS) definitions...
2016: Frontiers in Microbiology
Dafney L Davare, Zishan Chaudry, Rafael Sanchez, Seong K Lee, Chauniqua Kiffin, Andrew A Rosenthal, Eddy H Carrillo
Venous air embolus (VAE) occurs when gas, specifically atmospheric air, enters into the vascular system. Although rare, they can be fatal due to risk of cardiovascular collapse. In this report, we present a unique case of a 66-year-old female trauma patient with an inferior vena cava air embolism. An overview of the potential cause is presented, along with a review of the management of VAE.
2016: Journal of Surgical Case Reports
Reem Kayyali, Vilius Savickas, Martijn A Spruit, Evangelos Kaimakamis, Roshan Siva, Richard W Costello, John Chang, Barbara Pierscionek, Nikki Davies, Anouk W Vaes, Rita Paradiso, Nada Philip, Eleni Perantoni, Shona D'Arcy, Andreas Raptopoulos, Shereen Nabhani-Gebara
OBJECTIVES: To ascertain the stakeholders' views and devise recommendations for further stages of the Wearable Sensing and Smart Cloud Computing for Integrated Care to Chronic Obstructive Pulmonary Disease (COPD) Patients with Co-morbidities (WELCOME) system development. This system aims to create a wearable vest to monitor physiological signals for patients concerned incorporating an inhaler adherence monitoring, weight, temperature, blood pressure and glucose metres, and a mobile health application for communication with healthcare professionals (HCPs)...
2016: BMJ Open
Evelyn Mermans, Jan Degryse, Bert Vaes
BACKGROUND: The recent literature has shown that the risk of hypertension in the old strongly depends on their physical abilities. However, it is unknown whether general practitioners (GPs) adapt their treatment strategies to the patient's independence. This study was conducted to investigate the treatment intentions of GPs for patients aged 80 and older with hypertension in relation to the patients' level of dependency. METHODS: A vignette study in Belgium. Flemish GPs (n = 305) were invited, directly or indirectly, by email to fill out a questionnaire, consisting of nine cases (three themes)...
2016: BMC Family Practice
Duraid Younan, Russell Griffin, Maxwell Thompson, Thomas Swain, Matthew Honkanen, James C Crosby, Chandra V Ellis, Jean- Francois Pittet, Jeffrey D Kerby
OBJECTIVE: Coagulopathy is known to be associated with burn injury. Our group has showed that, in spinal cord injury patients, coagulopathy is associated with an increase in VAP. We hypothesized that the same association exists between coagulopathic burn patients and ventilator associated events. METHODS: Patients admitted for burn care between January 1, 2011 and December 31, 2015 who required mechanical ventilation were included in the study. Ventilator-associated events (VAEs) as defined by the Center for Disease Control were categorized as no event, ventilator-associated condition, infection-related ventilator-associated complication, and possible VAP...
August 24, 2016: Shock
David Beckwée, Peter Vaes, Steven Raeymaeckers, Maryam Shahabpour, Thierry Scheerlinck, Ivan Bautmans
PURPOSE: Exercise is effective for reducing knee osteoarthritis (OA) pain but effect sizes vary widely. Moreover, not all knee OA patients perceive beneficial effects. Tailoring specific exercises to subgroups of knee OA patients may increase effectivity. Bone marrow lesions (BMLs) have been suggested as a criterion to define such subgroups. This study aimed to investigate whether BMLs' presence/absence is related to treatment outcomes in a group of knee OA patients who exercised for 18 weeks...
August 19, 2016: Disability and Rehabilitation
W S Chen, J Liu, H Liu, Y Y Song, H Y Chen, R Wang, Y P Zhang, W Jiang, H F Li, S Q Li, S M Zhang, B Liu, X Zhang, W H Zhang
OBJECTIVE: The aim of this study was to prospectively investigate the incidence of ventilator associated events (VAEs) in intensive care units (ICUs) among adult patients, and to evaluate the correlation between VAEs and ventilator associated pneumonia (VAP). METHODS: A prospective 3-month cohort study (January 2015 to March 2015) was carried out. VAEs were divided into three groups: with ventilator-associated condition (VAC), with infection related ventilator-associated complication (IVAC) and with possible VAP (PVAP)...
August 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Pranee Rushatamukayanunt, Patchanon Seanho, Saipin Muangman, Manee Raksakietisak
BACKGROUND: Posterior cranial fossa surgery is commonly performed under sitting and horizontal position in our institution. Venous air embolism is a potentially serious complication of neurosurgery especially in the sitting position. OBJECTIVE: We aim to compare the incidence of severe venous air embolism and other complications of both positions. MATERIAL AND METHOD: A retrospective analysis of medical record was performed in 192 patients undergoing posterior cranial fossa craniotomy from January 2010 to December 2013...
May 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Benjamin T Himes, Grant W Mallory, Arnoley S Abcejo, Jeffrey Pasternak, John L D Atkinson, Fredric B Meyer, W Richard Marsh, Michael J Link, Michelle J Clarke, William Perkins, Jamie J Van Gompel
OBJECTIVE Historically, performing neurosurgery with the patient in the sitting position offered advantages such as improved visualization and gravity-assisted retraction. However, this position fell out of favor at many centers due to the perceived risk of venous air embolism (VAE) and other position-related complications. Some neurosurgical centers continue to perform sitting-position cases in select patients, often using modern monitoring techniques that may improve procedural safety. Therefore, this paper reports the risks associated with neurosurgical procedures performed in the sitting position in a modern series...
August 5, 2016: Journal of Neurosurgery
U Weissenstein, M Kunz, K Urech, U Regueiro, S Baumgartner
BACKGROUND: Besides conventional anticancer therapy many breast cancer patients use complementary and alternative medicine (CAM) like the medicinal herb mistletoe (Viscum album L.). To gain more knowledge about possible herb-drug interactions between CAM and conventional anticancer medications, in the present in vitro study we investigated the effect of a standardized mistletoe preparation on the action of Trastuzumab, a drug used for the treatment of Her-2 positive breast cancer. METHODS: The Her-2 positive human breast carcinoma cell line SK-BR-3 was treated with Trastuzumab...
2016: BMC Complementary and Alternative Medicine
Jae Kyeom Sim, Jee Youn Oh, Kyung Hoon Min, Gyu Young Hur, Seung Heon Lee, Sung Yong Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kyung Ho Kang
PURPOSE: A novel surveillance algorithm of ventilator-associated event (VAE) was introduced to overcome the subjectivity of conventional ventilator-associated pneumonia. We investigated the risk factors and prognostic values of VAE. METHODS: We conducted a retrospective study of 869 patients treated with mechanical ventilation for greater than or equal to 2 calendar days from January 2013 to June 2014. We compared the episodes of mechanical ventilation with or without VAE and analyzed risk factors and clinical outcomes of VAE...
October 2016: Journal of Critical Care
Aurora S Cruz, Marc Moisi, Jeni Page, R Shane Tubbs, David Paulson, Michael Zwillman, Rod Oskouian, Arthur Lam, David W Newell
Venous air embolism (VAE) is a known neurosurgical complication classically and most frequently occurring in patients undergoing posterior cranial fossa or cervical spine surgery in a sitting or semi-sitting position. The authors present a case of VAE that occurred during posterior cervical spine surgery in a patient in the prone position, a rare intraoperative complication. The patient was a 65-year-old man who was undergoing a C1-2 fusion for a nonunion of a Type II dens fracture and developed a VAE. While VAE in the prone position is uncommon, it is a neurosurgical complication that may have significant clinical implications both intraoperatively and postoperatively...
July 22, 2016: Journal of Neurosurgery. Spine
Klaartje Decaluwe, Jan Degryse, Bert Vaes
BACKGROUND: Multiple diagnostic algorithms for heart failure exist. However, it is unclear whether these algorithms are incorporated in the 'scripts' clinicians use in every day practice. Scripts are networks of organised knowledge that are acquired and accumulated during clinical training and are refined with each clinical encounter. This study was conducted to evaluate the scripts and thresholds that GPs use to diagnose heart failure in patients aged 75 years and older. METHODS: The scripts and thresholds of 130 Belgian GPs in training and 63 experienced trainers were compared using an online questionnaire based on the same principles as the script concordance test...
2016: BMC Family Practice
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