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TGF beta AND Silibinin

Sangmin Kim, Jeonghun Han, Myeongjin Jeon, Daeun You, Jeongmin Lee, Hee Jung Kim, Sarang Bae, Seok Jin Nam, Jeong Eon Lee
Transforming growth factor-beta (TGF-β) is a multifunctional cytokine that regulates many biological events including cell motility and angiogenesis. Here, we investigated the role of elevated TGF-β2 level in triple negative breast cancer (TNBC) cells and the inhibitory effect of silibinin on TGF-β2 action in TNBC cells. Breast cancer patients with high TGF-β2 expression have a poor prognosis. The levels of TGF-β2 expression increased significantly in TNBC cells compared with those in non-TNBC cells. In addition, cell motility-related genes such as fibronectin (FN) and matrix metalloproteinase-2 (MMP-2) expression also increased in TNBC cells...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yi-Hao Chen, Chang-Min Liang, Ching-Long Chen, Jiann-Torng Chen, Yun-Hsiang Chang, Da-Wen Lu, Ke-Hung Chien, Ming-Cheng Tai
PURPOSE: To investigate the effect of silibinin in myofibroblast transdifferentiation and in animal trabeculectomy models. METHODS: The effect of silibinin on the expression of α-smooth muscle actin (α-SMA) and vimentin in response to transforming growth factor-β1 (TGF-β1) was determined in human tenon fibroblasts (HTFs). Cell migration and collagen contraction arrays were used to demonstrate the functionality of silibinin-modulated HTFs. ELISA analysis was used to determine the effect of silibinin on the release of type 1 collagen and connective tissue growth factor (CTGF)...
November 2013: Acta Ophthalmologica
R Cristofalo, C F Bannwart-Castro, C G Magalhães, V T M Borges, J C Peraçoli, S S Witkin, M T Peraçoli
Silibinin is a polyphenolic plant flavonoid with anti-inflammatory properties. The present study investigated the effect of silibinin on oxidative metabolism and cytokine production - tumor necrosis factor-alpha (TNF-α), interleukin (IL)12, granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-6, IL-10, and transforming growth factor beta (TGF-β1) - by peripheral blood monocytes (PBM) from preeclamptic pregnant women. It is a case-controlled study involving women with preeclampsia (PE, n = 30) compared with normotensive pregnant (NT, n = 30) and with non-pregnant (NP, n = 30) women...
April 2013: Free Radical Research
Camila Ferreira Bannwart, Erika Nakaira-Takahagi, Marjorie Assis Golim, Leonardo Teixeira Lopes de Medeiros, Mariana Romão, Ingrid Cristina Weel, Maria Terezinha Serrão Peraçoli
AIMS: Silibinin is the major active component of silymarin, a polyphenolic plant flavonoid that has anti-inflammatory effects. The modulatory effect of silibinin on monocyte function against Paracoccidioides brasiliensis (Pb18) has not yet been demonstrated. The present study investigated whether the effect of silibinin on nuclear factor-kappa B (NF-kappaB) pathways may affect the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), transforming growth factor beta (TGF-beta1), prostaglandin E(2) (PGE(2)), nitric oxide (NO) and fungicidal activity of human monocytes challenged in vitro with Pb18...
June 5, 2010: Life Sciences
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