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accelerated partial breast irradiation

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https://www.readbyqxmd.com/read/29873283/external-partial-breast-irradiation-in-prone-position-how-to-improve-accuracy
#1
Chris Monten, Liv Veldeman, Katrien Vandecasteele, Luiza Oltéanu, Werner De Gersem, Tom Vercauteren, Thomas Mulliez, Rudy Van Den Broecke, Herman Depypere, Wilfried De Neve, Yolande Lievens
INTRODUCTION: In view of the limited incremental benefit between whole breast irradiation (WBI), accelerated partial breast irradiation (APBI) and omission of radiotherapy in favorable early-stage breast cancer (ESBC), APBI can only be justified if it combines adequate target coverage with the lowest achievable toxicity. Interobserver exercises demonstrated the difficulty of precise target delineation, especially in prone position; information on accuracy is even scarcer. We tested the impact of inserting an additional indicator clip, marking the depth of the tumor in the breast, and the added value of a preoperative CT in treatment position on precision and accuracy...
June 6, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29803696/multicatheter-interstitial-brachytherapy-for-breast-cancer
#2
S Sumodhee, V Strnad, J-M Hannoun-Lév
Brachytherapy remains the best irradiation technique to deliver a high dose in a small volume. Breast brachytherapy is part of the arsenal of therapy in the management of breast cancer. In this article, we present the technical data related to multicatheter interstitial brachytherapy to the breast proceeding, from the implantation of the vectors to the treatment itself. The indications for brachytherapy in breast cancer are boost after whole breast irradiation, accelerated partial breast irradiation or selected patients with second ipsilateral breast tumor event...
May 23, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29789758/advantages-of-intraoperative-implant-for-interstitial-brachytherapy-for-accelerated-partial-breast-irradiation-either-frail-patients-with-early-stage-disease-or-in-locally-recurrent-breast-cancer
#3
Salvatore Cozzi, Maria Laplana, Dina Najjari, Andrea Slocker, Xavier Encinas, Joan Pera, Ferran Guedea, Cristina Gutierrez
Purpose: To describe the intraoperative multicatheter implantation technique for accelerated partial breast irradiation (APBI) delivered with high-dose-rate brachytherapy (HDR-BT). Secondarily, to evaluate outcomes and toxicity in a series of 83 patients treated with this technique at our institution. Material and methods: Retrospective analysis of a series of patients treated with HDR-BT APBI after intraoperative multicatheter interstitial implant between November 2006 and June 2017 at our institution...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29781235/most-patients-are-eligible-for-an-alternative-to-conventional-whole-breast-irradiation-for-early-stage-breast-cancer-a-national-cancer-database-analysis
#4
Ehsan H Balagamwala, Bindu V Manyam, Charles Marc Leyrer, Naveen Karthik, Timothy Smile, Rahul D Tendulkar, Sheen Cherian, Diane Radford, Zahraa Al-Hilli, Frank Vicini, Chirag Shah
We evaluated the proportion of patients eligible for alternatives to standard whole breast irradiation (WBI) following breast-conserving surgery using the National Cancer Database (NCDB). Using the 2016 dataset, Stage I-III patients were identified. Eligibility for hypofractionated WBI (HFRT), accelerated partial breast irradiation (APBI) and endocrine therapy (ET-alone) was defined using eligibility from large clinical trials as well as consensus guidelines. For patients with pN0 breast cancer, 20.6% and 37...
May 20, 2018: Breast Journal
https://www.readbyqxmd.com/read/29760601/tumor-cell-accelerated-senescence-is-associated-with-dna-pkcs-status-and-telomere-dysfunction-induced-by-radiation
#5
Miaomiao Zhang, Xiaopeng Guo, Yue Gao, Dong Lu, Wenjian Li
Whether telomere structure integrity is related to radiosensitivity is not well investigated thus far. In this study, we investigated the relation between telomere instability and radiation-induced accelerated senescence. Partial knockdown of DNA-dependent catalytic subunit of protein kinase (DNA-PKcs) in human breast cancer cell line MCF-7 was established by small interfering RNA. Radiosensitivity of control and DNA-PKcs knockdown MCF-7 cells was analyzed by clonogenetic assay. Cell growth was measured by real-time cell electronic sensing...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29756165/study-on-the-dose-modification-factor-of-strut-adjusted-volume-implant-savi-with-a-169-yb-source-using-mcnp4c
#6
Seyed Milad Vahabi, Mostean Bahreinipour, Mojtaba Shamsaie Zafarghandi
The SAVI has gained widespread use for accelerated partial breast irradiation (APBI) brachytherapy. Treatments with SAVI produce inherent heterogeneities including variable backscatter due to proximity to the tissue-air interface and variable cavity contents, causing inaccuracy in the dose calculation. In this study, a model of SAVI with sources of 169 Yb developed recently was defined and simulations with MCNP4C code of Monte Carlo were performed through different scenarios to assess the effects of these heterogeneities on the dose distribution...
May 13, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29728221/dosimetric-advantages-afforded-by-a-new-irradiation-technique-dynamic-wavearc-used-for-accelerated-partial-breast-irradiation
#7
Yuka Ono, Michio Yoshimura, Kimiko Hirata, Tomohiro Ono, Hideaki Hirashima, Nobutaka Mukumoto, Mitsuhiro Nakamura, Minoru Inoue, Masahiro Hiraoka, Takashi Mizowaki
PURPOSE: To identify dosimetric advantages of the novel Dynamic WaveArc (DWA) technique for accelerated partial breast irradiation (APBI), compared with non-coplanar three-dimensional conformal radiotherapy (nc3D-CRT) and coplanar tangential volumetric modulated arc therapy (tVMAT) with dual arcs of 45-65°. METHODS: Vero4DRT enables DWA by continuous gantry rotation and O-ring skewing with movement of the multi-leaf collimator. We compared the dose distributions of DWA, nc3D-CRT and tVMAT in 24 consecutive left-sided breast cancer patients treated with APBI (38...
April 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29714197/synchrotron-radiation-external-beam-rotational-radiotherapy-of-breast-cancer-proof-of-principle
#8
Francesca Di Lillo, Giovanni Mettivier, Roberta Castriconi, Antonio Sarno, Andrew W Stevenson, Chris J Hall, Daniel Häusermann, Paolo Russo
The principle of rotational summation of the absorbed dose for breast cancer treatment with orthovoltage X-ray beams was proposed by J. Boone in 2012. Here, use of X-ray synchrotron radiation for image guided external beam rotational radiotherapy treatment of breast cancer is proposed. Tumor irradiation occurs with the patient in the prone position hosted on a rotating bed, with her breast hanging from a hole in the bed, which rotates around a vertical axis passing through the tumor site. Horizontal collimation of the X-ray beam provides for whole breast or partial breast irradiation, while vertical translation of the bed and successive rotations allow for irradiation of the full tumor volume, with dose rates which permit also hypofractionated treatments...
May 1, 2018: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/29695348/quality-of-life-results-for-accelerated-partial-breast-irradiation-with-interstitial-brachytherapy-versus-whole-breast-irradiation-in-early-breast-cancer-after-breast-conserving-surgery-gec-estro-5-year-results-of-a-randomised-phase-3-trial
#9
Rebekka Schäfer, Vratislav Strnad, Csaba Polgár, Wolfgang Uter, Guido Hildebrandt, Oliver J Ott, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, Jose Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, György Kovács, Arnt-René Fischedick, Rainer Fietkau, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Christine Gall, Bülent Polat
BACKGROUND: Previous results from the GEC-ESTRO trial showed that accelerated partial breast irradiation (APBI) using multicatheter brachytherapy in the treatment of early breast cancer after breast-conserving surgery was non-inferior to whole-breast irradiation in terms of local control and overall survival. Here, we present 5-year results of patient-reported quality of life. METHODS: We did this randomised controlled phase 3 trial at 16 hospitals and medical centres in seven European countries...
April 20, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29691075/estro-acrop-guideline-interstitial-multi-catheter-breast-brachytherapy-as-accelerated-partial-breast-irradiation-alone-or-as-boost-gec-estro-breast-cancer-working-group-practical-recommendations
#10
Vratislav Strnad, Tibor Major, Csaba Polgar, Michael Lotter, Jose-Luis Guinot, Cristina Gutierrez-Miguelez, Razvan Galalae, Erik Van Limbergen, Benjamin Guix, Peter Niehoff, Kristina Lössl, Jean-Michel Hannoun-Levi
PURPOSE: This consensus statement from the Breast Cancer Working Group of Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO) aims at generating practical guidelines for multi-catheter image-guided brachytherapy in the conservative management of breast cancer patients used for either Accelerated Partial Breast Irradiation (APBI) or for a breast boost. METHODS: Recent advances in techniques of multi-catheter brachytherapy were summarized and all the relevant literature was reviewed by a panel of experts...
April 21, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29642467/proton-partial-breast-irradiation-detailed-description-of-acute-clinico-radiologic-effects
#11
Valentina Ovalle, Eric A Strom, Simona Shaitelman, Karen Hoffman, Richard Amos, George Perkins, Welela Tereffe, Benjamin D Smith, Michael Stauder, Wendy Woodward
Introduction: Accelerated partial breast irradiation (APBI) with protons results in a very different acute effect profile than standard whole breast irradiation. We reviewed our initial experience with proton APBI and felt that a detailed description of these effects were needed to permit a common tool to compare experience with this developing technology. Methods: Sixty sequential patients treated with proton APBI on a prospective protocol were evaluated and 43 patients with a minimum six-month follow-up underwent detailed photographic and radiologic analysis...
April 7, 2018: Cancers
https://www.readbyqxmd.com/read/29622135/how-does-mr-imaging-help-care-for-my-breast-cancer-patient-perspective-of-a-radiation-oncologist
#12
REVIEW
Kaitlin M Christopherson, Benjamin D Smith
Radiation therapy is used in many cases of both early and late breast cancer. The authors examine the role of MR imaging as it pertains to radiotherapy planning and treatment approaches for patients with breast cancer. MR imaging can assist the radiation oncologist in determining the best radiation approach and in creating treatment planning volumes. MR imaging may be useful in the setting of accelerated partial breast irradiation. Radiation oncologists should attend to MR breast images, when obtained, to ensure that these imaging findings are taken into consideration when developing a radiation therapy plan...
May 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29619057/accelerated-partial-breast-irradiation-in-a-single-18-gy-fraction-with-high-dose-rate-brachytherapy-preliminary-results
#13
Javier Anchuelo Latorre, Piedad Galdós, Lucía Alonso Buznego, Ana García Blanco, Juan Cardenal, María Ferri, Iván Díaz de Cerio, Elisabet Arrojo, Nicolás Sierrasesúmaga, Mónica González Noriega, Ana De Juan Ferré, Rosa Fabregat, Samuel Ruíz, Pedro J Prada
Purpose: To evaluate the feasibility of acute and chronic toxicity in patients suitable for accelerated partial breast irradiation (APBI) in a single 18 Gy fraction with multicatheter high-dose-rate (HDR) brachytherapy, as well as cosmetic and oncological outcomes. Material and methods: Between September 2014 and March 2016, twenty consecutive patients with low-risk invasive and ductal carcinoma in situ were treated with interstitial multicatheter HDR brachytherapy in a single 18 Gy fraction...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29619056/should-molecular-subtype-be-recommended-as-one-of-the-selection-criteria-for-accelerated-partial-breast-irradiation-preliminary-results-from-an-asian-cohort
#14
Tabassum Wadasadawala, Monidipa Mondal, Siji Nojin Paul, Vani Parmar, Nita Nair, Tanuja Shet, Sangeeta Desai, Sudeep Gupta, Rajiv Sarin
Purpose: The purpose of this study was to report clinical outcomes in patients treated with accelerated partial breast irradiation (APBI), stratified as per molecular subtype and American Society for Therapeutic Radiology and Oncology/Groupe Européen de Curiethérapie and European Society for Radiotherapy & Oncology (ASTRO/GEC-ESTRO) patient selection criteria in order to determine whether molecular subtype should be recommended as one of the selection criteria for APBI. Material and methods: 157 early-stage breast cancers patients, treated with APBI using multi-catheter interstitial brachytherapy with ≥ 6 months follow-up were included...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29616366/de-escalation-of-breast-radiotherapy-after-conserving-surgery-in-low-risk-early-breast-cancer-patients
#15
REVIEW
Pierfrancesco Franco, Giuseppe Carlo Iorio, Sara Bartoncini, Mario Airoldi, Corrado De Sanctis, Isabella Castellano, Umberto Ricardi
The reduction in the burden related to treatment is becoming more and more important in modern oncology. Radiation therapy is a mainstay option in the postoperative setting for early breast cancer patients after breast-conserving surgery. Nowadays, different options are available to de-escalate radiotherapy in this scenario such as the use of hypofractionated whole-breast radiation, the selective delivery of the boost dose to the lumpectomy cavity, the introduction of accelerated partial breast irradiation and the omission of treatment in appropriately selected patients with low-risk features...
April 3, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29609845/evolution-of-brachytherapy-treatment-planning-to-deterministic-radiation-transport-for-calculation-of-cardiac-dose
#16
REVIEW
Peter A Sandwall, Yuntao Feng, Michael Platt, Michael Lamba, Sudha Mahalingam
Brachytherapy was among the first methods of radiotherapy and has steadily continued to evolve. Here we present a brief review of the progression of dose calculation methods in brachytherapy to the current state-of-the art computerized methods for heterogeneity correction. We further review the origin and development of the BrachyVision (Varian Medical Systems, Inc., Palo Alto, CA) treatment planning system and evaluate dosimetric results from 12 patients implanted with the strut-assisted volumetric implant (SAVI) applicator (Cianna Medical, Aliso Viejo, CA) for accelerated partial breast irradiation (APBI)...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29596547/targeted-intraoperative-radiation-therapy-a-promising-option-for-accelerated-partial-breast-irradiation
#17
Amishi Bajaj, Dennis R Holmes, William Small
No abstract text is available yet for this article.
March 29, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29594217/treatment-constraints-for-single-dose-external-beam-preoperative-partial-breast-irradiation-in-early-stage-breast-cancer
#18
Ramona K Charaghvandi, Sua Yoo, Bram van Asselen, Anna Rodrigues, Desirée H J G van den Bongard, Janet K Horton
Background: Following breast-conserving surgery and post-operative 3D-conformal accelerated partial breast irradiation (APBI), suboptimal cosmetic results have been reported. Preoperative radiation delivery to the intact tumor enables better target visualization and treatment volume reduction. Single dose preoperative APBI has the potential to improve toxicity profiles, reduce treatment burden and enable in vivo exploration of breast cancer radiogenomics. Purpose: Develop practical guidelines for single dose external beam preoperative APBI...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29566762/partial-breast-irradiation-with-cyberknife-after-breast-conserving-surgery-a-pilot-study-in-early-breast-cancer
#19
Laura Lozza, Laura Fariselli, Marco Sandri, Mario Rampa, Valentina Pinzi, Maria Carmen De Santis, Marzia Franceschini, Giovanna Trecate, Ilaria Maugeri, Luisa Fumagalli, Francesca Bonfantini, Giulia Bianchi, Emanuele Pignoli, Elena De Martin, Roberto Agresti
BACKGROUND: Local recurrences after breast conserving treatment are mainly close to the original tumor site, and as such shorter fractionation strategies focused on and nearest mammary gland, i.e. accelerated partial breast irradiation (APBI), have been developed. Stereotactic APBI has been attempted, although there is little experience using CyberKnife (CK) for early breast cancer. METHODS: This pilot study was designed to assess the feasibility of CK-APBI on 20 evaluable patients of 29 eligible, followed for 2 years...
March 23, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29513031/updated-astro-guidelines-on-accelerated-partial-breast-irradiation-apbi-to-whom-can-we-offer-apbi-outside-a-clinical-trial
#20
Anna M Kirby
The American Society of Radiation Oncology has recently updated its guidelines on the role of accelerated partial breast irradiation in the management of breast cancer. This commentary discusses the new recommendations and how we might advise patients in the light of existing data.
May 2018: British Journal of Radiology
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