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accelerated partial breast irradiation

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https://www.readbyqxmd.com/read/28205190/accelerated-partial-breast-irradiation-for-breast-cancer-not-ready-for-routine-use
#1
Jacqueline R Kelly, Suzanne Evans
No abstract text is available yet for this article.
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28205189/accelerated-partial-breast-irradiation-for-breast-cancer-an-innovative-option-for-selected-early-stage-cancers
#2
Robert R Kuske
No abstract text is available yet for this article.
February 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28132391/accelerated-partial-breast-irradiation-compared-with-whole-breast-radiation-therapy-a-breast-cancer-cohort-study-measuring-change-in-radiation-side-effects-severity-and-quality-of-life
#3
M Pérez, M Schootman, L E Hall, D B Jeffe
PURPOSE: Radiotherapy (RT) after breast-conserving surgery for early-stage breast cancer patients has similar survival benefits with whole breast RT (WBRT) or accelerated partial breast irradiation (APBI). However, the impact of RT type and side-effects severity on change in quality of life (QOL) is unknown. We examined changes in RT side-effects severity and QOL by RT type. METHODS: We analyzed data from a cohort of 285 newly diagnosed early-stage breast cancer patients with tumor size ≤3...
January 28, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28115956/whole-breast-irradiation-vs-apbi-using-multicatheter-brachytherapy-in-early-breast-cancer-simulation-of-treatment-costs-based-on-phase-3-trial-data
#4
Aleksandra Harat, Maciej Harat, Roman Makarewicz
PURPOSE: A recent large phase 3 trial demonstrated that the efficacy of accelerated partial-breast irradiation (APBI) in the treatment of early breast cancer is non-inferior to that of whole breast irradiation (WBI) commonly used in this indication. The aim of this study was to compare the costs of treatment with APBI and WBI in a population of patients after conserving surgery for early breast cancer, and to verify if the use of APBI can result in direct savings of a public payer. MATERIAL AND METHODS: The hereby presented cost analysis was based on the results of GEC-ESTRO trial...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28115955/clinical-outcomes-toxicity-and-cosmesis-in-breast-cancer-patients-with-close-skin-spacing-treated-with-accelerated-partial-breast-irradiation-apbi-using-multi-lumen-catheter-applicators
#5
Mani Akhtari, Mirna Abboud, Sean Szeja, Ramiro Pino, Gary D Lewis, Barbara L Bass, Darlene M Miltenburg, E Brian Butler, Bin S Teh
PURPOSE: Accelerated partial breast irradiation (APBI) using a single-lumen device is associated with better cosmetic outcomes if the spacing between the applicator and skin is > 7 mm. However, there are no reports addressing the late toxicity and clinical outcomes in patients treated with single-entry multi-lumen/catheter applicators who had close skin spacing (7 mm or less). We undertook this study to report clinical outcome, acute and late toxicity as well as cosmesis of early stage breast cancer patients with close skin spacing treated with APBI using multi-lumen or multi-catheter devices...
December 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28114948/current-controversies-in-radiotherapy-for-breast-cancer
#6
REVIEW
David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Marc D Piroth, Marie-Luise Sautter-Bihl, Felix Sedlmayer, Rainer Souchon, Frederik Wenz, Rolf Sauer
Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative and palliative intention in numerous clinical situations from precursor lesions such as ductal carcinoma in situ (DCIS) to advanced breast cancer. This review addresses current controversial topics in radiotherapy with special consideration of DCIS, accelerated partial breast irradiation (APBI) and regional nodal irradiation (RNI) and provides an update on the clinical practice guidelines of the Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)...
January 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28094198/late-side-effects-and-cosmetic-results-of-accelerated-partial-breast-irradiation-with-interstitial-brachytherapy-versus-whole-breast-irradiation-after-breast-conserving-surgery-for-low-risk-invasive-and-in-situ-carcinoma-of-the-female-breast-5-year-results
#7
Csaba Polgár, Oliver J Ott, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, José Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Rainer Fietkau, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Wolfgang Uter, Vratislav Strnad
BACKGROUND: We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial. METHODS: We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries...
January 13, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28094197/another-piece-in-the-jigsaw-of-accelerated-partial-breast-irradiation
#8
Charlotte E Coles
No abstract text is available yet for this article.
January 13, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28070767/strut-adjusted-volume-implant-savi-brachytherapy-based-accelerated-partial-breast-irradiation-apbi-in-african-american-women
#9
Amir Isbell, Jacquelyn Dunmore-Griffith, Olubunmi Abayomi
PURPOSE: To examine the clinical outcomes of postmenopausal African American (AA) women treated with strut-adjusted volume implant brachytherapy-based accelerated partial breast irradiation for early-stage node-negative breast cancer. METHODS: From January 2011 through April 2015, a total of 50 AA patients, meeting criteria to receive APBI as defined by the National Surgical Adjuvant Breast and Bowel Project B-39 (NASBP B-39), completed treatment with the SAVI breast brachytherapy device at Howard University Hospital...
January 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28063816/trends-in-the-use-of-implantable-accelerated-partial-breast-irradiation-for-ductal-carcinoma-in-situ-implications-of-the-recent-amendments-to-the-american-society-for-radiation-oncology-consensus-guidelines
#10
Waqar Haque, Vivek Verma, Anam Haque, E Brian Butler, Bin S Teh
PURPOSE: In 2009, the American Society for Radiation Oncology (ASTRO) published consensus recommendations that stated ductal carcinoma in situ (DCIS) patients were in a "cautionary" group for accelerated partial breast irradiation (APBI) and should not receive APBI outside of a clinical trial. However, very recently, ASTRO placed low-risk DCIS patients in the "suitable" category. Given this recent change, we aimed to use the Surveillance, Epidemiology, and End Results (SEER) database to evaluate past patterns of implantable APBI (IAPBI) utilization in women with DCIS...
January 4, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28048645/su-f-t-404-dosimetric-advantages-of-flattening-free-beams-to-prone-accelerated-partial-breast-irradiation
#11
P Galavis, D Barbee, G Jozsef
PURPOSE: Prone accelerated partial breast irradiation (APBI) results in dose reduction to the heart and lung. Flattening filter free beams (FFF) reduce out of field dose due to the reduced scatter from the removal of the flattening filter and reduce the buildup region. The aim of this work is to evaluate the dosimetric advantages of FFF beams to prone APBI target coverage and reduction in dose to organs at risk. METHODS: Fifteen clinical prone APBI cases using flattened photon beams were retrospectively re-planned in Eclipse-TPS using FFF beams...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048639/tu-h-209-02-quality-assurance-and-qmp-for-brachytherapy-treatment-delivery-and-treatment-planning-system
#12
M Chilukuri
Learnings Objectives: 1. Although brachytherapy is the oldest form of radiation therapy, the rapid advancement of the methods of dose calculation, treatment planning and treatment delivery pushes us to keep updating our knowledge and experience to new procedures all the time. Our purpose is to present the newest applicators used in Accelerated Partial Breast Irradiation (APBI) and the techniques of using them for a maximum effective treatment. Our objective will be to get the user familiar with the Savi, Contura and ML Mammosite from the detailed description and measurements to cavity eval and choice or size, to acceptance tests and use of each...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048623/tu-fg-201-10-quality-management-of-accelerated-partial-breast-irradiation-apbi-plans
#13
H Ji, V Lorio, G Cernica, J Han, M Nurhussien, N Nasr, R Hong
PURPOSE: Since 2008, over 700 patients received high dose rate (HDR) APBI treatment at Virginia Hospital Center. The complexity involved in the planning process demonstrated a broad variation between patient geometry across all applicators, in relation to anatomical regions of interest. A quality management program instituting various metrics was implemented in March 2013 with the goal of ensuring an optimal plan is achieved for each patient. METHODS: For each plan, an in-house complexity index, geometric conformity index, and plan quality index were defined...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048196/su-f-t-22-clinical-implications-when-using-tg-186-ace-heterogeneity-software
#14
A Likhacheva, E Grade, A Sadeghi, T Sokolowski
PURPOSE: The purpose of this study is to compare dosimetric calculations using traditional TG-43 formalism and Oncentra Brachy Advanced Collapsed cone Engine (ACE) TG-186 calculation algorithm in clinical setting. METHODS: We analyzed dosimetry of four patients treated with accelerated partial breast irradiation using a multi-channel intracavitary device (SAVI). All patients were treated to 34 Gy in 10 fractions using a high-dose-rate (192) Ir source. The plans were designed and treated using the TG-43 model...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048104/su-f-t-58-dosimetric-evaluation-of-breast-tissue-composition-for-electronic-brachytherapy-bet-source-in-high-dose-rate-accelerated-partial-breast-apbi-irradiation
#15
W Taylor, D Johnson, S Ahmad, Y Chen
PURPOSE: To quantitatively evaluate the dosimetric impact of differing breast tissue compositions for electronic brachytherapy source for high dose rate accelerated partial breast irradiation. METHODS: A series of Monte Carlo Simulation were created using the GEANT4 toolkit (version 10.0). The breast phantom was modeled as a semi-circle with a radius of 5.0 cm. A water balloon with a radius of 1.5 cm was located in the phantom with the Xoft AxxentTM EBT source placed at center as a point source...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047974/tu-h-209-03-planning-and-treatment-delivery-for-apbi-using-savi-contura-and-ml-mammosite
#16
S Pella
Learnings Objectives: 1. Although brachytherapy is the oldest form of radiation therapy, the rapid advancement of the methods of dose calculation, treatment planning and treatment delivery pushes us to keep updating our knowledge and experience to new procedures all the time. Our purpose is to present the newest applicators used in Accelerated Partial Breast Irradiation (APBI) and the techniques of using them for a maximum effective treatment. Our objective will be to get the user familiar with the Savi, Contura and ML Mammosite from the detailed description and measurements to cavity eval and choice or size, to acceptance tests and use of each...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047861/su-f-t-317-skin-exposure-outside-the-treatment-field-during-treatment-of-breast-cancer-with-tri-co-60-mr-igrt-system
#17
J Park, J Kim, S Park, S Kim, K Shin
PURPOSE: To investigate exposure outside the treatment field when treating breast cancer with tri-Co-60 magnetic resonance (MR) image guided radiation therapy (IGRT) system. METHODS: A total of 7 patients who treated with accelerated partial breast irradiation (APBI) technique were selected prospectively for this study (prescription dose = 38.5 Gy in 10 fractions). Every patient treated with two plans, one was an initial plan and the other was an adaptive plan generated after finishing 5 fractions (a total of 14 plans)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047707/su-g-201-14-is-maximum-skin-dose-a-reliable-metric-for-accelerated-partial-breast-irradiation-with-brachytherapy
#18
S Park, O Ragab, S Patel, Y Kim, J Demanes, M Kamrava
PURPOSE: To evaluate the reliability of the maximum point dose (Dmax) to the skin surface as a dosimetric constraint, we investigated the correlation between Dmax at the skin surface and dose metrics at various definitions of skin thickness. METHODS: 42 patients treated with APBI using a Strut Adjusted Volume Implant (SAVI) applicator between 2010 and 2014 were retrospectively reviewed. Target (PTV_EVAL) and organs at risk (OARs: skin, lung, and ribs) were delineated on a CT following NSABP B-39 guidelines...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047662/su-f-t-537-prone-breast-accelerated-partial-breast-irradiation-using-non-coplanar-volumetric-arc-therapy
#19
G Beninati, J Barbiere, L Godfrey, A Ndlovu
PURPOSE: To demonstrate that Volumetric Modulated Arc Therapy (VMAT) can be an alternative technique to Brachytherapy Accelerated Partial Breast Irradiation (APBI) for treating large breasted women. The non-coplanar VMAT technique uses a commercially available couch and a small number of angles. This technique with the patient in the prone position can reduce high skin and critical structure doses in large breasted women, which are usually associated with Brachytherapy APBI. METHODS: Philips Pinnacle treatment planning system with Smart Arc was used to plan a left sided laterally located excision cavity on a standard prone breast patient setup...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047487/su-f-t-01-optimization-of-the-accelerated-partial-breast-brachytherapy-fractionation-with-consideration-of-physical-doses-to-tumor-and-organ-at-risk
#20
W Fu, M Huq
PURPOSE: The accelerated partial breast irradiation (APBI) with brachytherapy prescribes 34Gy to be delivered in 10 fractions over 5 consecutive working days without considering the physical dose to the target and organs at risk (OARs) for an individual patient. The purpose of this study is to optimize the fractionation scheme by evaluating the radiation effect on tumor and OARs with a modified linear-quadratic (LQ) model based on dose-volume histograms (DVHs). METHODS: Five breast patients treated with multilumen balloon brachytherapy were selected...
June 2016: Medical Physics
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