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accelerated partial breast irradiation

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https://www.readbyqxmd.com/read/28986987/monte-carlo-simulations-of-a-kilovoltage-external-beam-radiotherapy-system-on-phantoms-and-breast-patients
#1
Dylan Y Breitkreutz, Michael D Weil, Sergei Zavgorodni, Magdalena Bazalova-Carter
PURPOSE: To determine the most suitable lesion size and depth for radiotherapy treatments with a prototype kilovoltage x-ray arc therapy (KVAT) system through Monte Carlo simulations of the dose delivered to lesion, dose homogeneity and lesion-to-skin ratio. METHODS: Monte Carlo simulations were used to calculate dose distributions generated by a novel low-energy kilovoltage x-ray system to a variety of clinically relevant lesion sizes and depths in phantoms and for hypothetical partial breast irradiations of patients in supine and prone positions...
October 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28938661/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#2
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28916952/air-electron-stream-interactions-during-magnetic-resonance-igrt-skin-irradiation-outside-the-treatment-field-during-accelerated-partial-breast-irradiation
#3
Jong Min Park, Kyung Hwan Shin, Jung-In Kim, So-Yeon Park, Seung Hyuck Jeon, Noorie Choi, Jin Ho Kim, Hong-Gyun Wu
PURPOSE: To investigate and to prevent irradiation outside the treatment field caused by an electron stream in the air generated by the magnetic field during magnetic resonance image-guided accelerated partial breast irradiation (APBI). MATERIALS AND METHODS: In all, 20 patients who received APBI with a magnetic resonance image-guided radiation therapy (MR-IGRT) system were prospectively studied. The prescription dose was 38.5 Gy in 10 fractions of 3.85 Gy and delivered with a tri-cobalt system (the ViewRay system)...
September 15, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28869144/efficiency-of-using-the-day-of-implant-ct-for-planning-of-savi-apbi
#4
Michael B Altman, Karen E Mooney, Sharbacha Edward, Jose L Garcia-Ramirez, Todd A Dewees, Maria A Thomas, Imran Zoberi, Jacqueline E Zoberi
PURPOSE: The purpose of the study was to develop an optimized, efficient workflow for using the day-of-implant (DOI) CT for treatment planning of accelerated partial breast irradiation brachytherapy using the strut-adjusted volume implant (SAVI) device. METHODS AND MATERIALS: For 62 consecutive SAVI patients, a DOI CT was acquired and used for treatment planning. A "verification" CT was acquired 24-72 h after implant and immediately before the first fraction, then registered to the DOI CT...
August 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28844820/clinical-implementation-of-a-novel-double-balloon-single-entry-breast-brachytherapy-applicator
#5
Bethany M Anderson, Charles R Wallace, Anna-Maria A De Costa, Rupak K Das
PURPOSE: The purpose of the study was to describe the clinical utilization of a novel Double-Balloon applicator for accelerated partial breast irradiation (APBI). METHODS AND MATERIALS: The Double-Balloon single-entry breast applicator contains a single central treatment catheter, as well as four peripheral catheters that can be differentially loaded to customize radiation dose coverage. An inner balloon is filled with up to 7-30 cm(3) of saline to increase separation between the peripheral catheters, and an outer balloon is filled with up to 37-115 cm(3) of saline to displace breast tissue from the peripheral catheters...
August 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28816144/comparison-of-treatment-outcome-between-invasive-lobular-and-ductal-carcinomas-in-patients-receiving-partial-breast-irradiation-with-intraoperative-electrons
#6
COMPARATIVE STUDY
Maria Cristina Leonardi, Patrick Maisonneuve, Mauro Giuseppe Mastropasqua, Federica Cattani, Giuseppe Fanetti, Anna Morra, Roberta Lazzari, Federica Bazzani, Mariangela Caputo, Nicole Rotmensz, Marianna Alessandra Gerardi, Rosalinda Ricotti, Viviana Enrica Galimberti, Paolo Veronesi, Samantha Dicuonzo, Giuseppe Viale, Barbara Alicja Jereczek-Fossa, Roberto Orecchia
PURPOSE: To investigate the local outcome of patients after accelerated partial breast irradiation with intraoperative electrons (IORT) for invasive lobular carcinoma (ILC) compared with invasive ductal carcinoma (IDC). METHODS AND MATERIALS: From 1999 to 2007, 2173 patients were treated with breast-conserving surgery and IORT (21 Gy/1 fraction) as the sole local treatment: 252 patients with ILC (11.6%) were compared with 1921 patients with IDC in terms of local control...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28766205/a-single-institution-retrospective-comparison-study-of-locoregional-recurrence-after-accelerated-partial-breast-irradiation-using-external-beam-fractionation-compared-with-whole-breast-irradiation-with-8%C3%A2-years-of-follow-up
#7
Shalin Shah, Alexandra Kyrillos, Kristine Kuchta, Hussain Habib, Megan Tobias, Vathsala Raghavan, Arif Shaikh, William Bloomer, Catherine Pesce, Katharine Yao
BACKGROUND: Accelerated partial breast irradiation (APBI) was developed to address disadvantages of overall treatment time and potentially unnecessary radiation associated with whole breast irradiation (WBI). We report updated results of our single institution study using an external beam APBI regimen with a median follow-up of 8 years. METHODS: A total of 290 APBI patients with AJCC Stage 0-II breast cancer were compared with 290 WBI patients with matched tumor characteristics...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28766200/keynote-address-at-the-american-society-of-breast-surgeons-18th-annual-meeting-current-and-future-application-of-intraoperative-radiotherapy-iort-in-the-curative-and-palliative-treatment-of-breast-cancer
#8
Frederik Wenz
Intraoperative radiotherapy (IORT) is increasingly used worldwide. Breast cancer is the most rapidly growing indication for IORT, approaching 70-80% of cases in most centers. This report reviews the theoretical background and clinical use of IORT for primary and metastasized breast cancer. There are established applications such as tumor bed boost during breast-conserving surgery followed by whole breast radiotherapy or IORT as a form of accelerated partial-breast irradiation (APBI) for selected patients. Novel applications such as IORT for vertebral or brain metastases are presented as well as technological developments, widening the spectrum of potential clinical applications for IORT...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28764924/partial-breast-irradiation-with-interstitial-multi-catheter-high-dose-rate-brachytherapy-long-term-results-of-a-phase-ii-prospective-study
#9
Cynthia Aristei, Ernesto Maranzano, Valentina Lancellotta, Luigia Chirico, Claudio Zucchetti, Marco Italiani, Paola Anselmo, Cristina Mariucci, Elisabetta Perrucci, Fabio Arcidiacono, Fabio Trippa, György Kovacs, Vittorio Bini, Isabella Palumbo
PURPOSE: We report the long-term results of phase II prospective study with accelerated partial breast irradiation (APBI) using interstitial multi-catheter high-dose-rate brachytherapy. METHODS: 240 patients received APBI (4Gy, twice daily; total dose 32Gy). RESULTS: Median follow-up was 96months. Recurrences in the treated breast developed in 8 patients (3.3%) at a median of 73months after APBI. The 5- and 10-year cumulative incidences were respectively, 1...
August 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28757401/impact-of-adjuvant-systemic-chemotherapy-on-wound-healing-and-cosmetic-outcome-in-224-women-treated-with-accelerated-partial-breast-irradiation-using-interstitial-brachytherapy
#10
Ashwini Budrukkar, Prakash Pandit, Tabassum Wadasadawala, Ritu Raj Upreti, Rakesh Jalali, Sudeep Gupta, Tanuja Shet, Vani Parmar, Rajendra Badwe, Rajiv Sarin
PURPOSE: To evaluate the impact of timing of adjuvant chemotherapy on wound healing and cosmetic outcome in women treated with accelerated partial breast irradiation (APBI). METHODS AND MATERIALS: Between August 2000 to December 2011, 224 women were treated with APBI using multicatheter interstitial high-dose-rate brachytherapy. Patients were treated to a dose of 34 Gy/10#/5-7 days with bid regimen. Systemic chemotherapy was administered as per the standard guidelines...
July 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28750134/performance-evaluation-of-a-collapsed-cone-dose-calculation-algorithm-for-hdr-ir-192-of-apbi-treatments
#11
Dario Terribilini, Veronika Vitzthum, Werner Volken, Daniel Frei, Kristina Loessl, Bob van Veelen, Peter Manser, Michael K Fix
PURPOSE: Most dose calculations for HDR brachytherapy treatments are based on the AAPM-TG43 formalism. Because patient's anatomy, heterogeneities, and applicator shielding are not considered, the dose calculation based on this formalism is inaccurate in some cases. Alternatively, collapsed cone (CC) methods as well as Monte Carlo (MC) algorithms belong to the model-based dose calculation algorithms, which are expected to improve the accuracy of calculated dose distributions. In this work, the performance of a CC algorithm, ACE in Oncentra Brachy 4...
October 2017: Medical Physics
https://www.readbyqxmd.com/read/28732369/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#12
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28705082/projected-improvements-in-accelerated-partial-breast-irradiation-using-a-novel-breast-stereotactic-radiotherapy-device-a-dosimetric-analysis
#13
James W Snider, Yildirim Mutaf, Elizabeth Nichols, Andrea Hall, Patrick Vadnais, William F Regine, Steven J Feigenberg
Accelerated partial breast irradiation has caused higher than expected rates of poor cosmesis. At our institution, a novel breast stereotactic radiotherapy device has demonstrated dosimetric distributions similar to those in brachytherapy. This study analyzed comparative dose distributions achieved with the device and intensity-modulated radiation therapy accelerated partial breast irradiation. Nine patients underwent computed tomography simulation in the prone position using device-specific immobilization on an institutional review board-approved protocol...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28697858/accelerated-partial-breast-irradiation-for-elderly-women-with-early-breast-cancer-a-compromise-between-whole-breast-irradiation-and-omission-of-radiotherapy
#14
Shakeel Sumodhee, Johan Levy, Emmanuel Chamorey, Daniel Lam Cham Kee, Marie-Eve Chand, Mathieu Gautier, Isabelle Peyrottes, Emmanuel Barranger, Jean-Michel Hannoun-Levi
PURPOSE: Regarding adjuvant radiation therapy making decision for elderly women, Albert (2013) published a nomogram predicting the mastectomy-free survival (MFS) rate with or without adjuvant irradiation. Based on this approach, we proposed to investigate the use of accelerated partial breast irradiation (APBI) vs. whole breast irradiation (WBI) or endocrine therapy alone in elderly low-risk breast cancer patients. METHODS AND MATERIALS: For each elderly woman treated by conserving surgery and APBI (multicatheter interstitial high-dose-rate brachytherapy), 5- and 10-year MFS rates were calculated...
July 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28676428/american-brachytherapy-society-consensus-report-for-accelerated-partial-breast-irradiation-using-interstitial-multicatheter-brachytherapy
#15
REVIEW
Jaroslaw T Hepel, Douglas Arthur, Simona Shaitelman, Csaba Polgár, Dorin Todor, Imran Zoberi, Mitchell Kamrava, Tibor Major, Catheryn Yashar, David E Wazer
PURPOSE: To develop a consensus report for the quality practice of accelerated partial breast irradiation (APBI) using interstitial multicatheter brachytherapy (IMB). METHODS AND MATERIALS: The American Brachytherapy Society Board appointed an expert panel with clinical and research experience with breast brachytherapy to provide guidance for the current practice of IMB. This report is based on a comprehensive literature review with emphasis on randomized data and expertise of the panel...
July 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28675577/in-support-of-the-choosing-wisely-campaign-perceived-higher-risk-leads-to-unnecessary-imaging-in-accelerated-partial-breast-irradiation
#16
Audrey S Wallace, Jay P Nelson, Zhenyu Wang, Paul S Dale, Gregory B Biedermann
Accelerated partial breast irradiation (APBI) is an increasingly utilized modality for early stage breast cancer as part of breast conservation therapy (BCT). There remains concern regarding local recurrence, requiring more frequent post-radiation surveillance imaging. The purpose of this study is to determine clinical significance of frequent surveillance in this perceived higher risk population. Patients treated at a community academic medical center from 2005 to 2013 with partial breast radiation were retrospectively identified...
July 4, 2017: Breast Journal
https://www.readbyqxmd.com/read/28645692/clinical-implementation-of-combined-modulated-electron-and-photon-beams-with-conventional-mlc-for-accelerated-partial-breast-irradiation
#17
Carlos Míguez, Elisa Jiménez-Ortega, Bianey A Palma, Hector Miras, Ana Ureba, Rafael Arráns, Francisco Carrasco-Peña, Ana Illescas-Vacas, Antonio Leal
PURPOSE: To report the clinical implementation of a novel external beam radiotherapy technique for accelerated partial breast irradiation treatments based on combined electron and photon modulated beams radiotherapy (MERT+IMRT) with conventional MLC. MATERIALS AND METHODS: A group of patients was selected to test the viability of the technique. The prescribed dose was 38.5Gy, following a hypofractionated schema, and the structures were defined following the NSABP-B39/RTOG-0413 protocol...
June 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28600139/change-of-target-volume-and-its-dosimetric-impact-during-the-course-of-accelerated-partial-breast-irradiation-using-intraoperative-multicatheter-interstitial-brachytherapy-after-open-cavity-surgery
#18
Ritu Raj Upreti, Ashwini Budrukkar, Udita Upreti, Shagun Misra, Tabassum Wadasadawala, Satish Kohle, Deepak D Deshpande
PURPOSE: To investigate the change of clinical target volume (CTV) and its dosimetric impact during the course of accelerated partial breast irradiation (APBI) using intraoperative multicatheter interstitial brachytherapy after open cavity surgery. METHODS AND MATERIALS: Twenty-two patients of APBI with intraoperative placement of catheters underwent computed tomography scans for the treatment planning before the first (CT1) and the last (CT2) treatment fraction...
June 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28597470/breast-conservation-for-male-breast-cancer-case-report-of-intraoperative-radiation
#19
Ameer Gomberawalla, Peter Liou, Rebecca Martinez, Raj Rajpara, Eileen Connolly, David Horowitz, Sheldon Feldman
Male breast cancer (MBC) comprises <1% of all breast cancers in the United States. MBC is typically treated with total mastectomy while the majority of female breast cancer is treated with breast conservation therapy combined with various forms of radiation. One method that has developed over the last two decades is the use of intraoperative radiation therapy (IORT) as a type of accelerated partial breast irradiation to direct the treatment field to the tumor bed. Since overall prognosis and systemic therapy recommendations for MBC are similar to breast cancer in women, we describe the first case of MBC treated with BCS and IORT...
June 8, 2017: Breast Journal
https://www.readbyqxmd.com/read/28533802/interobserver-variations-of-target-volume-delineation-and-its-impact-on-irradiated-volume-in-accelerated-partial-breast-irradiation-with-intraoperative-interstitial-breast-implant
#20
Ritu Raj Upreti, Ashwini Budrukkar, Tabassum Wadasadawala, Shagun Misra, Lavanya Gurram, Rima Pathak, Deepak D Deshpande
PURPOSE: To investigate the interobserver variations in delineation of lumpectomy cavity (LC) and clinical target volume (CTV), and its impact on irradiated volume in accelerated partial breast irradiation using intraoperative multicatheter brachytherapy. MATERIAL AND METHODS: Delineation of LC and CTV was done by five radiation oncologists on planning computed tomography (CT) scans of 20 patients with intraoperative interstitial breast implant. Cavity visualization index (CVI), four-point index ranging from (0 = poor) to (3 = excellent) was created and assigned by observers for each patient...
April 2017: Journal of Contemporary Brachytherapy
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