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CD103+ dendritic cell

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https://www.readbyqxmd.com/read/29784675/radiation-followed-by-ox40-stimulation-drives-local-and-abscopal-antitumor-effects-in-an-anti-pd1-resistant-lung-tumor-model
#1
Sharareh Niknam, Hampartsoum B Barsoumian, Jonathan E Schoenhals, Heather Jackson, Niranjan Yanamandra, Mauricio S Caetano, Ailin Li, Ahmed I Younes, Alexandra P Cadena, Taylor R Cushman, Joe Y Chang, Quynh Nguyen, Daniel R Gomez, Adi Diab, John V Heymach, Patrick Hwu, Maria Angelica Cortez, James W Welsh
PURPOSE: Radiation is used extensively to treat localized cancer, but improved understanding of its effects on the immune system have increased interest in its potential systemic (abscopal) effects, particularly in combination with checkpoint inhibitors such as anti-PD1. The majority of patients either do not respond or develop resistance to monotherapy over time. Here, we investigated the efficacy of OX40 (CD134) stimulation as an alternative immunotherapeutic approach in combination with radiotherapy (XRT) in a murine model of anti-PD1-resistant lung tumors...
May 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29760082/a-cytokine-network-involving-il-36%C3%AE-il-23-and-il-22-promotes-antimicrobial-defense-and-recovery-from-intestinal-barrier-damage
#2
Vu L Ngo, Hirohito Abo, Estera Maxim, Akihito Harusato, Duke Geem, Oscar Medina-Contreras, Didier Merlin, Andrew T Gewirtz, Asma Nusrat, Timothy L Denning
The gut epithelium acts to separate host immune cells from unrestricted interactions with the microbiota and other environmental stimuli. In response to epithelial damage or dysfunction, immune cells are activated to produce interleukin (IL)-22, which is involved in repair and protection of barrier surfaces. However, the specific pathways leading to IL-22 and associated antimicrobial peptide (AMP) production in response to intestinal tissue damage remain incompletely understood. Here, we define a critical IL-36/IL-23/IL-22 cytokine network that is instrumental for AMP production and host defense...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29735643/flow-cytometry-data-preparation-guidelines-for-improved-automated-phenotypic-analysis
#3
Daniel Jimenez-Carretero, José M Ligos, María Martínez-López, David Sancho, María C Montoya
Advances in flow cytometry (FCM) increasingly demand adoption of computational analysis tools to tackle the ever-growing data dimensionality. In this study, we tested different data input modes to evaluate how cytometry acquisition configuration and data compensation procedures affect the performance of unsupervised phenotyping tools. An analysis workflow was set up and tested for the detection of changes in reference bead subsets and in a rare subpopulation of murine lymph node CD103+ dendritic cells acquired by conventional or spectral cytometry...
May 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29669782/the-respiratory-environment-diverts-the-development-of-antiviral-memory-cd8-t-cells
#4
Hillary L Shane, Katie L Reagin, Kimberly D Klonowski
Our understanding of memory CD8+ T cells has been largely derived from acute, systemic infection models. However, memory CD8+ T cells generated from mucosal infection exhibit unique properties and, following respiratory infection, are not maintained in the lung long term. To better understand how infection route modifies memory differentiation, we compared murine CD8+ T cell responses to a vesicular stomatitis virus (VSV) challenge generated intranasally (i.n.) or i.v. The i.n. infection resulted in greater peak expansion of VSV-specific CD8+ T cells...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29593283/breast-and-pancreatic-cancer-interrupt-irf8-dependent-dendritic-cell-development-to-overcome-immune-surveillance
#5
Melissa A Meyer, John M Baer, Brett L Knolhoff, Timothy M Nywening, Roheena Z Panni, Xinming Su, Katherine N Weilbaecher, William G Hawkins, Cynthia Ma, Ryan C Fields, David C Linehan, Grant A Challen, Roberta Faccio, Rebecca L Aft, David G DeNardo
Tumors employ multiple mechanisms to evade immune surveillance. One mechanism is tumor-induced myelopoiesis, whereby the expansion of immunosuppressive myeloid cells can impair tumor immunity. As myeloid cells and conventional dendritic cells (cDCs) are derived from the same progenitors, we postulated that myelopoiesis might impact cDC development. The cDC subset, cDC1, which includes human CD141+ DCs and mouse CD103+ DCs, supports anti-tumor immunity by stimulating CD8+ T-cell responses. Here, to understand how cDC1 development changes during tumor progression, we investigated cDC bone marrow progenitors...
March 28, 2018: Nature Communications
https://www.readbyqxmd.com/read/29581197/tnf%C3%AE-antagonism-reveals-a-gut-lung-axis-that-amplifies-regulatory-t-cells-in-a-pulmonary-fungal-infection
#6
Jamie L Tweedle, George S Deepe
Tumor necrosis factor (TNF) antagonists are popular therapies for inflammatory diseases. These agents enhance numbers and function of regulatory T cells (Tregs) which are important in controlling inflammatory diseases. However, elevated Tregs increase susceptibility to infections, including histoplasmosis. We determined the mechanism by which Tregs expand in TNF-neutralized mice infected with Histoplasma capsulatum Lung CD11c+ CD11b+ dendritic cells (DC), but not alveolar macrophages, from H. capsulatum -infected mice treated with anti-TNF induced a higher percentage of Tregs than control DC in vitro...
March 26, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29563179/skin-resident-t-cells-drive-dermal-dendritic-cell-migration-in-response-to-tissue-self-antigen
#7
Niwa Ali, Bahar Zirak, Hong-An Truong, Megan M Maurano, Iris K Gratz, Abul K Abbas, Michael D Rosenblum
Migratory dendritic cell (DC) subsets deliver tissue Ags to draining lymph nodes (DLNs) to either initiate or inhibit T cell-mediated immune responses. The signals mediating DC migration in response to tissue self-antigen are largely unknown. Using a mouse model of inducible skin-specific self-antigen expression, we demonstrate that CD103+ dermal DCs (DDCs) rapidly migrate from skin to skin DLN (SDLNs) within the first 48 h after Ag expression. This window of time was characterized by the preferential activation of tissue-resident Ag-specific effector T cells (Teffs), with no concurrent activation of Ag-specific Teffs in SDLNs...
May 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29543979/colonization-induced-protection-against-invasive-pneumococcal-disease-in-mice-is-independent-of-cd103-driven-adaptive-immune-responses
#8
Anne Dommaschk, Lara F Lang, Regina Maus, Jennifer Stolper, Tobias Welte, Ulrich A Maus
Nasopharyngeal colonization with Streptococcus pneumoniae (the pneumococcus) is known to mount protective adaptive immune responses in rodents and humans. However, the cellular response of the nasopharyngeal compartment to pneumococcal colonization and its importance for the ensuing adaptive immune response is only partially defined. Here we show that nasopharyngeal colonization with S. pneumoniae triggered substantial expansion of both integrin αE (CD103) positive dendritic cells (DC) and T lymphocytes in nasopharynx, nasal-associated lymphoid tissue (NALT) and cervical lymph nodes (CLN) of WT mice...
March 15, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29515025/nlrp3-dependent-il-1%C3%AE-inhibits-cd103-dendritic-cell-differentiation-in-the-gut
#9
Rachel Mak'Anyengo, Peter Duewell, Cornelia Reichl, Christine Hörth, Hans-Anton Lehr, Sandra Fischer, Thomas Clavel, Gerald Denk, Simon Hohenester, Sebastian Kobold, Stefan Endres, Max Schnurr, Christian Bauer
Inflammatory bowel disease (IBD) is associated with enhanced levels of the IL-1 family cytokines IL-1β and IL-18, which are activated by the Nlrp3 inflammasome. Here, we investigated the role of inflammasome-driven cytokine release on T cell polarization and DC differentiation in steady state and T cell transfer colitis. In vitro and in vivo data showed that IL-1β induces Th17 polarization and increases GM‑CSF production by T cells. Reduced IL-1β levels in Nlrp3-/- mice correlated with enhanced FLT3L levels and increased frequency of tolerogenic CD103+ DC...
March 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29507107/clec9a-dendritic-cells-are-not-essential-for-antitumor-cd8-t-cell-responses-induced-by-poly-i-c-immunotherapy
#10
Connie B Gilfillan, Sabine Kuhn, Camille Baey, Evelyn J Hyde, Jianping Yang, Christiane Ruedl, Franca Ronchese
In the steady state, tumors harbor several populations of dendritic cells (DCs) and myeloid cells that are key regulators of the intratumoral immune environment. Among these cells, migratory CD103+ cross-presenting DCs are thought to be critical for tumor-specific CTL responses and tumor resistance. However, it is unclear whether this prominent role also extends to immunotherapy. We used a murine orthotopic mammary tumor model, as well as Clec9A-diphtheria toxin receptor mice that can be depleted of the specialized cross-presenting CD8α+ and CD103+ DC1 subsets, to investigate the role of these DCs in immunotherapy...
April 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29491406/fc%C3%AE-ri-co-stimulation-converts-human-intestinal-cd103-dendritic-cells-into-pro-inflammatory-cells-through-glycolytic-reprogramming
#11
Ivo S Hansen, Lisette Krabbendam, Jochem H Bernink, Fabricio Loayza-Puch, Willianne Hoepel, Johan A van Burgsteden, Elsa C Kuijper, Christianne J Buskens, Willem A Bemelman, Sebastiaan A J Zaat, Reuven Agami, Gestur Vidarsson, Gijs R van den Brink, Esther C de Jong, Manon E Wildenberg, Dominique L P Baeten, Bart Everts, Jeroen den Dunnen
CD103+ dendritic cells (DC) are crucial for regulation of intestinal tolerance in humans. However, upon infection of the lamina propria this tolerogenic response is converted to an inflammatory response. Here we show that immunoglobulin A (IgA) immune complexes (IgA-IC), which are present after bacterial infection of the lamina propria, are important for the induction of inflammation by the human CD103+ SIRPα+ DC subset. IgA-IC, by recognition through FcαRI, selectively amplify the production of proinflammatory cytokines TNF, IL-1β and IL-23 by human CD103+ DCs...
February 28, 2018: Nature Communications
https://www.readbyqxmd.com/read/29488131/mechanisms-of-oral-tolerance
#12
REVIEW
Leticia Tordesillas, M Cecilia Berin
Oral tolerance is a state of systemic unresponsiveness that is the default response to food antigens in the gastrointestinal tract, although immune tolerance can also be induced by other routes, such as the skin or inhalation. Antigen can be acquired directly by intestinal phagocytes, or pass through enterocytes or goblet cell-associated passages prior to capture by dendritic cells (DCs) in the lamina propria. Mucin from goblet cells acts on DCs to render them more tolerogenic. A subset of regulatory DCs expressing CD103 is responsible for delivery of antigen to the draining lymph node and induction of Tregs...
February 27, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29474842/the-invariant-natural-killer-t-cell-mediated-chemokine-x-c-motif-chemokine-ligand-1-x-c-motif-chemokine-receptor-1-axis-promotes-allergic-airway-hyperresponsiveness-by-recruiting-cd103-dendritic-cells
#13
Yeon Duk Woo, Jaemoon Koh, Hye-Ryun Kang, Hye Young Kim, Doo Hyun Chung
BACKGROUND: The chemokine X-C motif chemokine ligand 1 (XCL1)-X-C motif chemokine receptor 1 (XCR1) axis has been reported to play a role in immune homeostasis and inflammation. However, it is not known whether this axis has a critical function in patients with allergic asthma. OBJECTIVE: In the present study we explored whether the invariant natural killer T (iNKT) cell-mediated XCL1-XCR1 axis regulated allergic asthma. METHODS: Ovalbumin (OVA)- or house dust mite-induced asthma was developed in XCL1 or XCR1 knockout (KO) mice...
February 21, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29455474/aging-impacts-cd103-cd8-t-cell-presence-and-induction-by-dendritic-cells-in-the-genital-tract
#14
Marta Rodriguez-Garcia, Jared M Fortier, Fiona D Barr, Charles R Wira
As women age, susceptibility to systemic and genital infections increases. Tissue-resident memory T cells (TRMs) are CD103+ CD8+ long-lived lymphocytes that provide critical mucosal immune protection. Mucosal dendritic cells (DCs) are known to induce CD103 expression on CD8+ T cells. While CD103+ CD8+ T cells are found throughout the female reproductive tract (FRT), the extent to which aging impacts their presence and induction by DCs remains unknown. Using hysterectomy tissues, we found that endometrial CD103+ CD8+ T cells were increased in postmenopausal compared to premenopausal women...
February 18, 2018: Aging Cell
https://www.readbyqxmd.com/read/29422901/identification-of-a-potential-common-ancestor-for-mammalian-cross-presenting-dendritic-cells-in-teleost-respiratory-surfaces
#15
Irene Soleto, Uwe Fischer, Carolina Tafalla, Aitor G Granja
Dendritic cells (DCs) are highly specialized antigen-presenting cells that bridge innate and adaptive immune responses in vertebrates, being key modulators in the initiation of specific responses. Although teleost fish present the main elements of a fully developed adaptive immune system, not many studies have focused on identifying specific DC subsets in teleost species. Previous work from our group identified in rainbow trout ( Oncorhynchus mykiss ) skin a DC subpopulation co-expressing CD8α and major histocompatibility complex II β on the cell surface...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29409680/routing-dependent-immune-responses-after-experimental-r848-adjuvated-vaccination
#16
Susan van Aalst, Manon A A Jansen, Irene S Ludwig, Ruurd van der Zee, Willem van Eden, Femke Broere
Most traditional vaccines are administered via the intramuscular route. Other routes of administration however, can induce equal or improved protective memory responses and might provide practical advantages such as needle-free immunization, dose sparing and induction of tissue-specific (mucosal) immunity. Here we explored the differences in immunological outcome after immunization with model antigens via two promising immunization routes (intradermal and intranasal) with or without the experimental adjuvant and TLR7/8-agonist R848...
March 7, 2018: Vaccine
https://www.readbyqxmd.com/read/29403496/recent-advances-in-targeting-cd8-t-cell-immunity-for-more-effective-cancer-immunotherapy
#17
REVIEW
Aurélie Durgeau, Yasemin Virk, Stéphanie Corgnac, Fathia Mami-Chouaib
Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and programmed cell death (PD)-1. In this context, anti-CTLA-4 and anti-PD-1 monoclonal antibodies have demonstrated survival benefits in numerous cancers, including melanoma and non-small-cell lung carcinoma. PD-1-expressing CD8+ T lymphocytes appear to play a major role in the response to these immune checkpoint inhibitors (ICI). Cytotoxic T lymphocytes (CTL) eliminate malignant cells through recognition by the T-cell receptor (TCR) of specific antigenic peptides presented on the surface of cancer cells by major histocompatibility complex class I/beta-2-microglobulin complexes, and through killing of target cells, mainly by releasing the content of secretory lysosomes containing perforin and granzyme B...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29399390/ccl3-augments-tumor-rejection-and-enhances-cd8-t-cell-infiltration-through-nk-and-cd103-dendritic-cell-recruitment-via-ifn%C3%AE
#18
Frederick Allen, Iuliana D Bobanga, Peter Rauhe, Deborah Barkauskas, Nathan Teich, Caryn Tong, Jay Myers, Alex Y Huang
Inflammatory chemokines are critical contributors in attracting relevant immune cells to the tumor microenvironment and driving cellular interactions and molecular signaling cascades that dictate the ultimate outcome of host anti-tumor immune response. Therefore, rational application of chemokines in a spatial-temporal dependent manner may constitute an attractive adjuvant in immunotherapeutic approaches against cancer. Existing data suggest that the macrophage inflammatory protein (MIP)-1 family and related proteins, consisting of CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES), can be major determinant of immune cellular infiltration in certain tumors through their direct recruitment of antigen presenting cells, including dendritic cells (DCs) to the tumor site...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29374077/cd11b-dendritic-cell-mediated-anti-mycobacterium-tuberculosis-th1-activation-is-counterregulated-by-cd103-dendritic-cells-via-il-10
#19
Rocky Lai, Mangalakumari Jeyanathan, Sam Afkhami, Anna Zganiacz, Joanne A Hammill, Yushi Yao, Charu Kaushic, Zhou Xing
Mycobacterium tuberculosis , the pathogen causing pulmonary tuberculosis (TB) in humans, has evolved to delay Th1 immunity in the lung. Although conventional dendritic cells (cDCs) are known to be critical to the initiation of T cell immunity, the differential roles and molecular mechanisms of migratory CD11b+ and CD103+ cDC subsets in anti- M. tuberculosis Th1 activation remain unclear. Using a murine model of pulmonary M. tuberculosis infection, we found that slow arrival of M. tuberculosis -bearing migratory CD11b+ and CD103+ cDCs at the draining lymph nodes preceded the much-delayed Th1 immunity and protection in the lung...
March 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29361165/single-blood-transfusion-induces-the-production-of-donor-specific-alloantibodies-and-regulatory-t-cells-mainly-in-the-spleen
#20
Hisashi Ueta, Yusuke Kitazawa, Yasushi Sawanobori, Takamasa Ueno, Satoshi Ueha, Kouji Matsushima, Kenjiro Matsuno
Donor-specific blood transfusion is known to induce alloresponses and lead to immunosuppression. We examined their underlying mechanisms by employing fully allogeneic rat combinations. Transfused recipients efficiently produced alloantibodies of the IgM and IgG subclasses directed against donor class I MHC. The recipients exhibited active expansion of CD4+ T cells and CD4+FOXP3+ regulatory T cells (Treg cells), followed by CD45R+ B cells and IgM+ or IgG subclass+ antibody-forming cells mainly in the spleen...
March 8, 2018: International Immunology
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