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https://www.readbyqxmd.com/read/27651256/role-of-quercetin-benefits-in-neurodegeneration
#1
Preetham Elumalai, Sreeja Lakshmi
Neurodegenerative disorders are often life threatening and hired as an economic burden to the health-care system. Nutritional interventions principally involving polyphenols were practiced to arrest or reverse the age-related health disorders. Flavonoids, a class of dietary polyphenols, are rising to superstardom in preventing brain disorders with their potent antioxidant defense mechanism. Quercetin is a ubiquitous flavonoid reported to have all-natural myriad of health benefits. Citrus fruits, apple, onion, parsley, berries, green tea, and red wine comprise the major dietary supplements of quercetin apart from some herbal remedies like Ginkgo biloba...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27308960/circadian-disruption-new-clinical-perspective-of-disease-pathology-and-basis-for-chronotherapeutic-intervention
#2
Michael H Smolensky, Ramon C Hermida, Alain Reinberg, Linda Sackett-Lundeen, Francesco Portaluppi
Biological processes are organized in time as innate rhythms defined by the period (τ), phase (peak [Φ] and trough time), amplitude (A, peak-trough difference) and mean level. The human time structure in its entirety is comprised of ultradian (τ < 20 h), circadian (20 h > τ < 28 h) and infradian (τ > 28 h) bioperiodicities. The circadian time structure (CTS) of human beings, which is more complicated than in lower animals, is orchestrated and staged by a brain central multioscillator system that includes a prominent pacemaker - the suprachiasmatic nuclei of the hypothalamus...
2016: Chronobiology International
https://www.readbyqxmd.com/read/26110573/the-microbiome-and-cancer-implications-for-oncology-nursing-science
#3
Debra Lynch Kelly, Debra E Lyon, Saunjoo L Yoon, Ann L Horgas
BACKGROUND: Approximately 1.6 million Americans were diagnosed with cancer in 2014. To combat their disease, many individuals received either curative or palliative treatments that produced undesired symptoms. These symptoms, which often cause significant distress for individuals coping with cancer, may share biologic underpinnings such as epigenetic changes and immune dysregulation. Alterations in the normal flora of the gut may also influence cancer symptoms. OBJECTIVE: The aim of this review is to describe the emerging role for the gut microbiome in cancer research, especially the potential relationship between the gut microbiome and cancer symptoms...
May 2016: Cancer Nursing
https://www.readbyqxmd.com/read/25752883/malnutrition-is-associated-with-worse-health-related-quality-of-life-in-children-with-cancer
#4
Aeltsje Brinksma, Robbert Sanderman, Petrie F Roodbol, Esther Sulkers, Johannes G M Burgerhof, Eveline S J M de Bont, Wim J E Tissing
PURPOSE: Malnutrition in childhood cancer patients has been associated with lower health-related quality of life (HRQOL). However, this association has never actually been tested. Therefore, we aimed to determine the association between nutritional status and HRQOL in children with cancer. METHODS: In 104 children, aged 2-18 years and diagnosed with hematological, solid, or brain malignancies, nutritional status and HRQOL were assessed at diagnosis and at 3, 6, and 12 months using the child- and parent-report versions of the PedsQL 4...
October 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/25524476/an-enigmatic-l-carnosine-%C3%AE-alanyl-l-histidine-cell-proliferative-activity-as-a-fundamental-property-of-a-natural-dipeptide-inherent-to-traditional-antioxidant-anti-aging-biological-activities-balancing-and-a-hormonally-correct-agent-novel-patented-oral-therapy
#5
REVIEW
Mark A Babizhayev, Yegor E Yegorov
Hypothalamic releasing and inhibiting hormones are major neuroendocrine regulators of human body metabolism being driven directly to the anterior pituitary gland via hypothalamic-hypophyseal portal veins. The alternative physiological or therapeutic interventions utilizing the pharmaco-nutritional boost of imidazole-containing dipeptides (non-hydrolized oral form of carnosine, carcinine, N-acetylcarnosine lubricant eye drops) can maintain health, enhance physical exercise performance and prevent ageing. Carnosine (β-alanyl-L-histidine) is synthesized in mammalian skeletal muscle...
2015: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/24499118/black-tea-polyphenols-a-mechanistic-treatise
#6
REVIEW
M S Butt, A Imran, M K Sharif, Rabia Shabir Ahmad, Hang Xiao, M Imran, H A Rsool
Dietary interventions are among the emerging trends to curtail physiological malfunctioning like cancer, diabetes, cardiac complications, etc. The essence of phytonutrients has developed the concept of nutraceuticals at the junction of diet health linkages. In this context, theaflavin & thearubigins are the oxidized derivatives of black tea catechins during fermentation having nutraceutical potential owing to esterification of hydroxyl ring with digallate esters. Theaflavin may influence activation of transcription factors such as NFnB or AP-1 that ultimately hinder the formation of nitric oxide expression gene...
2014: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/23737534/sex-specific-transcriptional-responses-of-the-zebrafish-danio-rerio-brain-selenoproteome-to-acute-sodium-selenite-supplementation
#7
Maia J Benner, Matt L Settles, Gordon K Murdoch, Ronald W Hardy, Barrie D Robison
The potential benefits of selenium (Se) supplementation are currently under investigation for prevention of certain cancers and treatment of neurological disorders. However, little is known concerning the response of the brain to increased dietary Se under conditions of Se sufficiency, despite the majority of Se supplementation trials occurring in healthy, Se sufficient subjects. We evaluated the transcriptional response of Se-dependent genes, selenoproteins and the genes necessary for their synthesis (the selenoproteome), in the zebrafish (Danio rerio) brain to supplementation with nutritionally relevant levels of dietary Se (sodium selenite) during conditions of assumed Se sufficiency...
August 1, 2013: Physiological Genomics
https://www.readbyqxmd.com/read/23255159/children-s-oncology-group-s-2013-blueprint-for-research-cancer-control-and-supportive-care
#8
REVIEW
Lillian Sung, Theo Zaoutis, Nicole J Ullrich, Donna Johnston, Lee Dupuis, Elena Ladas
In cancer control research, the objective is to reduce overall morbidity and mortality by decreasing acute and delayed treatment-related toxicities in all children with cancer. To date, the Children's Oncology Group (COG) has focused on infection, neurocognition, quality of life (QoL), and nutrition/antiemetics. COG is conducting randomized controlled trials (RCTs) to determine prophylaxis strategies that will reduce infections in high-risk populations. Two RCTs are determining if modafinil or computerized cognitive training improve cognitive functioning in pediatric brain tumor patients...
June 2013: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/22731395/reduction-in-neural-activation-to-high-calorie-food-cues-in-obese-endometrial-cancer-survivors-after-a-behavioral-lifestyle-intervention-a-pilot-study
#9
Nora L Nock, Anastasia Dimitropolous, Jean Tkach, Heidi Frasure, Vivan von Gruenigen
BACKGROUND: Obesity increases the risk of endometrial cancer (EC) and obese EC patients have the highest risk of death among all obesity-associated cancers. However, only two lifestyle interventions targeting this high-risk population have been conducted. In one trial, food disinhibition, as determined by the Three-Factor Eating Questionnaire, decreased post-intervention compared to baseline, suggesting an increase in emotional eating and, potentially, an increase in food related reward...
2012: BMC Neuroscience
https://www.readbyqxmd.com/read/21810420/beyond-anorexia-cachexia-nutrition-and-modulation-of-cancer-patients-metabolism-supplementary-complementary-or-alternative-anti-neoplastic-therapy
#10
Alessandro Laviano, Marilia Seelaender, Karla Sanchez-Lara, Ioannis Gioulbasanis, Alessio Molfino, Filippo Rossi Fanelli
Anorexia and muscle wasting are frequently observed in cancer patients and influence their clinical outcome. The better understanding of the mechanisms underlying behavioral changes and altered metabolism yielded to the development of specialized nutritional support, which enhances utilization of provided calories and proteins by counteracting some of the metabolic derangements occurring during tumor growth. Inflammation appears to be a key factor determining the cancer-associated biochemical abnormalities eventually leading to anorexia and cachexia...
September 2011: European Journal of Pharmacology
https://www.readbyqxmd.com/read/21106923/total-antioxidant-capacity-of-the-diet-is-associated-with-lower-risk-of-ischemic-stroke-in-a-large-italian-cohort
#11
Daniele Del Rio, Claudia Agnoli, Nicoletta Pellegrini, Vittorio Krogh, Furio Brighenti, Teresa Mazzeo, Giovanna Masala, Benedetta Bendinelli, Franco Berrino, Sabina Sieri, Rosario Tumino, Patrizia Concetta Rollo, Valentina Gallo, Carlotta Sacerdote, Amalia Mattiello, Paolo Chiodini, Salvatore Panico
Experimental studies suggest that oxidative stress and systemic inflammation are involved in the pathogenesis of ischemic stroke. Consuming a diet with a high total antioxidant capacity (TAC) has been related to reduced inflammation and increased circulating antioxidants in cross-sectional and randomized intervention studies. This study investigates the relation between dietary TAC and risk of ischemic and hemorrhagic stroke in 41,620 men and women not previously diagnosed with stroke or myocardial infarction, representing the Italian segment of the European Prospective Investigation into Cancer and Nutrition...
January 2011: Journal of Nutrition
https://www.readbyqxmd.com/read/20388101/the-hormetic-role-of-dietary-antioxidants-in-free-radical-related-diseases
#12
REVIEW
V Calabrese, C Cornelius, A Trovato, M Cavallaro, C Mancuso, L Di Rienzo, D Condorelli, A De Lorenzo, E J Calabrese
Regular consumption of cruciferous vegetables or spices is associated with a reduced incidence of cancer and reduction of markers for neurodegenerative damage. Furthermore, greater health benefit may be obtained from raw as opposed to cooked vegetables. Nutritional interventions, by increasing dietary intake of fruits and vegetables, can retard and even reverse age-related declines in brain function and cognitive performance. The mechanisms through which dietary supplementation with antioxidants may be useful to prevent free radical-related diseases is related to their ability to counteract toxic production of both reactive oxygen and nitrogen species, along with the up-regulation of vitagenes, such as members of the heat shock protein (Hsp) family heme oxygenase-1 and Hsp70...
2010: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/19921735/a-multidimensional-examination-of-correlates-of-fatigue-during-radiotherapy
#13
Amanda Purcell, Jennifer Fleming, Sally Bennett, Kathleen McGuane, Bryan Burmeister, Terry Haines
BACKGROUND: Cancer-related fatigue can be measured as both a unidimensional and a multidimensional construct. Unidimensional fatigue and its symptom correlates have undergone some previous investigation; however, minimal research has considered the differential effect of correlates on individual dimensions of fatigue. The objective of the current study was to investigate cancer-related fatigue in a radiotherapy sample using a multidimensional conceptualization to determine whether correlates of fatigue are consistent across all dimensions or whether each fatigue dimension has its own unique pattern of correlates...
January 15, 2010: Cancer
https://www.readbyqxmd.com/read/17039990/wernicke-encephalopathy-presented-in-the-form-of-postoperative-delirium-in-a-patient-with-hepatocellular-carcinoma-and-liver-cirrhosis-a-case-report-and-review-of-the-literature
#14
REVIEW
Hideki Onishi, Yukio Sugimasa, Chiaki Kawanishi, Masanari Onose
OBJECTIVE: Although Wernicke encephalopathy has been reported in the oncological literature, it has not previously been reported in postoperative cancer patients. METHODS: In this communication, we report a patient of hepatocellular carcinoma with liver cirrhosis who developed Wernicke encephalopathy in the form of postoperative delirium. Preoperatively, the patient had a very good appetite and had eaten all the food of an 1800 cal/day diet until 1 day before operation...
December 2005: Palliative & Supportive Care
https://www.readbyqxmd.com/read/17039989/development-of-wernicke-encephalopathy-in-a-terminally-ill-cancer-patient-consuming-an-adequate-diet-a-case-report-and-review-of-the-literature
#15
Suzu Yae, Shigeko Okuno, Hideki Onishi, Chiaki Kawanishi
Malignancy-associated primary thiamine deficiency has been documented in several experimental tumors, clinical case reports, and in patients with fast growing malignancies. We report a terminally ill cancer patient who developed delirium. Close examination of the patient demonstrated that delirium was caused by thiamine deficiency, although she had been consuming an average of 990 cal/day for the past 3 weeks. Malabsorption or consumption by the tumor was considered the mechanism of thiamine deficiency. Early recognition and subsequent treatment resulted in successful palliation of delirium...
December 2005: Palliative & Supportive Care
https://www.readbyqxmd.com/read/16251636/new-nutrition-proteomics-and-how-both-can-enhance-studies-in-cancer-prevention-and-therapy
#16
Helen Kim
The increased application of MS technologies to nutrition and cancer prevention research has enabled unique insights into the health benefits of polyphenols. Polyphenols are phytochemicals that appear to have chemical properties that provide valuable health benefits when ingested. In particular, experiments have suggested that grape seed proanthocyanidins, oligomers of the catechin family of polyphenols, may have health benefits, possibly due to their capacity to be oxidized. Two-dimensional gel proteomics technology identified specific rat brain proteins that were differentially affected after ingestion of grape seed extract...
November 2005: Journal of Nutrition
https://www.readbyqxmd.com/read/15784476/can-oxidative-damage-be-treated-nutritionally
#17
REVIEW
Mette M Berger
BACKGROUND & AIMS: Nutrition and dietary patterns have been shown to have direct impact on health of the population and of selected patient groups. The beneficial effects have been attributed to the reduction of oxidative damage caused by the normal or excessive free radical production. The papers aims at collecting evidence of successful supplementation strategies. METHODS: Review of the literature reporting on antioxidant supplementation trials in the general population and critically ill patients...
April 2005: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/15345150/redox-regulation-in-neurodegeneration-and-longevity-role-of-the-heme-oxygenase-and-hsp70-systems-in-brain-stress-tolerance
#18
REVIEW
Vittorio Calabrese, A M Giuffrida Stella, D Allan Butterfield, Giovanni Scapagnini
Efficient functioning of maintenance and repair processes seems to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed "vitagenes," among these, the heat shock system, a highly conserved mechanism responsible for the preservation and repair of cellular macromolecules, such as proteins, RNAs, and DNA. Recent studies have shown that the heat shock response contributes to establishing a cytoprotective state in a wide variety of human diseases, including ischemia and reperfusion damage, inflammation, cancer, as well as metabolic and neurodegenerative disorders...
October 2004: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/15148583/-palliative-treatment-for-colorectal-cancer
#19
REVIEW
D Flieger, R Keller, W Fischbach
Over 50,000 new cases of colorectal cancer are diagnosed in Germany every year. About half of these patients will be cured by surgery. The other reoccur or present primarily with advanced disease. Recently, the survival of patients with metastasized disease has been prolonged from about 6 months with best supportive care alone to more than 20 months with combination chemotherapy. Therefore, adequate palliation is reasonable. Irresectable liver metastasis can be treated by locally ablative procedures such as radiofrequency ablation (RFA) or laserinduced thermotherapy (LITT)...
July 2004: Der Internist
https://www.readbyqxmd.com/read/15141340/successful-treatment-of-wernicke-encephalopathy-in-terminally-ill-cancer-patients-report-of-3-cases-and-review-of-the-literature
#20
Hideki Onishi, Chiaki Kawanishi, Masanari Onose, Tomoki Yamada, Hideyuki Saito, Akira Yoshida, Kazumasa Noda
Although Wernicke encephalopathy has been reported in the oncological literature, only one terminally ill cancer patient with Wernicke encephalopathy has been reported. Wernicke encephalopathy, a potentially reversible condition, may be unrecognized in terminally ill cancer patients. In this communication, we report three terminally ill cancer patients who developed Wernicke encephalopathy. Early recognition and subsequent treatment resulted in successful palliation of delirium. Two of the three patients did not show the classical triad of Wernicke encephalopathy...
August 2004: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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