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JOURNAL ARTICLE
Caroline E Plant, Alexander Ooms, Jonathan A Cook, Matthew L Costa, Melina Dritsaki, Helen Dakin, Jonathan Jones, Andrew Mckee, Kevin Smith, Mohamed Hamadto, Steve Gwilym, Tim Chesser, Jaime Candal-Couto, Caroline Hing, David Giddin, Phil Johnston, Aamer Ullah, John Williams, Will Eardley, Makaram Srinivasan, Sridharrao Sampalli, Mark Farrar, Chris Roberts, Khitish Mohanty, Iain MacLeod, Praveen Sarda, Amr Elseehy, Nigel Rossiter, David Warwick, Chris Peach, David MacKay, Richard Benson, Adam Watts, Jonathan Young, Feisal Shah, Stephen Lipscombe, Aaron Ng, Charalambos P. Charalambous, Barnaby Sheriden, Kanthan Theivendran, Pulimamidi Sanjay, Rajesh Nanda, Antony Bateman, Michael Butler, Oliver Keast-Butler, Andrew McAndrew, Wystan Chevannes, Pradeep Kankanalu, Asanka Wijendra, Andreas Fontalis, Hytham Afifi, Marie-Clare Killen, Ryan Higgin, Warran Wignadasan, Ken Wong, Catherine Gibson, Harry Beale, Bob Jennings, James Kennedy, Mark Williamson, Damir Rasidovic, Lydia Jenner, John B Tadros, Steve Milner, James Duncan, Sally Kerr, Louise Nordin, Matt Weston, Olivia Payton, Tofi Oni, Craig Zhao, Sukhdeep Gill, Mohammad Iqbal, Marie-Clare Killen, Khaled Aneiba, Warran Wignadasan, Dilip Pillai, Luke Hughes, Jonathan Crosby, Mike Whitehouse, Thomas Corbett, Arshad Iqbal, Steph Buchan, Laura Beddard, Venkat Vardhan, Becky Beamish, Matt Jones, Jonathan Holley, Rebecca Morrell, Robin Lerner, Kylea Draper
AIMS: The primary aim of this study was to report the radiological outcomes of patients with a dorsally displaced distal radius fracture who were randomized to a moulded cast or surgical fixation with wires following manipulation and closed reduction of their fracture. The secondary aim was to correlate radiological outcomes with patient-reported outcome measures (PROMs) in the year following injury. METHODS: Participants were recruited as part of DRAFFT2, a UK multicentre clinical trial...
February 13, 2024: Bone & joint open
#2
JOURNAL ARTICLE
Grey Giddins
Complications are a recognized hazard of surgery. The term is confusing; it has multiple meanings, including surgical error and adverse surgical outcomes. I propose the latter two terms are used. Grading of 'complications' is difficult but made easier by grading errors and outcomes separately, though they are not always linked. The exact grades are not established.Error avoidance requires efforts at a personal (surgeon) level, including training, learning and preparation, and at a systems level. Understanding human factors is important...
February 2024: Journal of Hand Surgery, European Volume
#3
JOURNAL ARTICLE
Jennifer C E Lane, Anna Loch Wilkinson, Grey Giddins, Maxim D Horwitz
Little is known of the scale of avoidable injuries presenting to medical services on a national level in the UK. This study aimed to assess the type and incidence of preventable wrist and hand injuries (as defined by the core research team) at a national level in the UK. 28 UK hospitals undertook a service evaluation of all hand trauma cases presenting to their units over a 2 week period in early 2021 identifying demographical and aetiological information about injuries sustained. 1909 patients were included (184 children) with a median age of 40 (IQR 25-59) years...
December 2023: JPRAS Open
#4
JOURNAL ARTICLE
Amanda Jane Blatch-Jones, Alejandra Recio Saucedo, Beth Giddins
BACKGROUND: Preprints are open and accessible scientific manuscript or report that is shared publicly, through a preprint server, before being submitted to a journal. The value and importance of preprints has grown since its contribution during the public health emergency of the COVID-19 pandemic. Funders and publishers are establishing their position on the use of preprints, in grant applications and publishing models. However, the evidence supporting the use and acceptability of preprints varies across funders, publishers, and researchers...
2023: PloS One
#5
REVIEW
Neil Vargesson, Geoffrey Hooper, Grey Giddins, Alastair Hunter, Paul Stirling, Wee Lam
This review article provides a comprehensive overview of thalidomide upper limb embryopathy including updates about its pathogenesis, a historical account of the management of the paediatric thalidomide patient, experience with management of the adult patient, as well as creating awareness about early onset age-related changes associated with limb differences. Despite its withdrawal from the market in November 1961, novel discoveries have meant thalidomide is licensed again and currently still in use to treat a variety of conditions, including inflammatory disorders and some cancers...
May 24, 2023: Journal of Hand Surgery, European Volume
#6
REVIEW
Grey Giddins
The importance of distal radioulnar joint problems associated with distal radial fractures is recognized increasingly. But there remains considerable disagreement about how to treat these problems both acutely and chronically. This review outlines the knowledge about the natural history of ulnar-sided wrist problems with distal radials fractures. In particular, the recent increased understanding of the almost inevitable joint instability associated with distal radial fractures is highlighted, including the unreliability of clinical assessment and hence why there has been so much misunderstanding...
January 13, 2023: Journal of Hand Surgery, European Volume
#7
RANDOMIZED CONTROLLED TRIAL
Fredrik Peyronson, Cecilia Stalberg Ostwald, Nils P Hailer, Grey Giddins, Torbjörn Vedung, Daniel Muder
This article was updated on January 18, 2023, because of a previous error, which was discovered after the preliminary version of the article was posted online. On page 103, in the first column of Table III, the continuous outcomes, which had been given as "Median" and "(range)", are now given as "Mean" and "(95% CI)", respectively.
January 18, 2023: Journal of Bone and Joint Surgery. American Volume
#8
JOURNAL ARTICLE
D J C Grindlay, T R C Davis, D Kennedy, D Larson, D Furniss, K Cowan, G Giddins, A Jain, R W Trickett, A Karantana
BACKGROUND: To report our recommended methodology for extracting and then confirming research uncertainties - areas where research has failed to answer a research question - derived from previously published literature during a broad scope Priority Setting Partnership (PSP) with the James Lind Alliance (JLA). METHODS: This process was completed in the UK as part of the PSP for "Common Conditions Affecting the Hand and Wrist", comprising of health professionals, patients and carers and reports the data (uncertainty) extraction phase of this...
November 10, 2022: BMC Medical Research Methodology
#9
JOURNAL ARTICLE
Aylin Caliskan, Samantha A W Crouch, Sara Giddins, Thomas Dandekar, Seema Dangwal
Since ancient times aging has also been regarded as a disease, and humankind has always strived to extend the natural lifespan. Analyzing the genes involved in aging and disease allows for finding important indicators and biological markers for pathologies and possible therapeutic targets. An example of the use of omics technologies is the research regarding aging and the rare and fatal premature aging syndrome progeria (Hutchinson-Gilford progeria syndrome, HGPS). In our study, we focused on the in silico analysis of differentially expressed genes (DEGs) in progeria and aging, using a publicly available RNA-Seq dataset (GEO dataset GSE113957) and a variety of bioinformatics tools...
September 29, 2022: Biomedicines
#10
JOURNAL ARTICLE
Medini K Annavajhala, Nicole E Kelly, Wenjing Geng, Samantha A Ferguson, Marla J Giddins, Emily C Grohs, Alexandra Hill-Ricciuti, Daniel A Green, Lisa Saiman, Anne-Catrin Uhlemann
Methicillin-susceptible Staphylococcus aureus (MSSA) is a more prevalent neonatal intensive care unit (NICU) pathogen than methicillin-resistant S. aureus (MRSA). However, the introduction and spread of MSSA, the role of systematic decolonization, and optimal infection prevention and control strategies remain incompletely understood. We previously screened infants hospitalized in a university-affiliated level III to IV NICU twice monthly over 18 months for S. aureus colonization and identified several prevalent staphylococcal protein A ( spa ) types...
October 11, 2022: MSphere
#11
JOURNAL ARTICLE
Joshua A Parry, Joseph Chavarria, Sara Giddins, David Rojas, Cyril Mauffrey, Todd Baldini, Yang Lv
OBJECTIVE: Cefazolin is a heat-labile antibiotic that is not usually added to polymethylmethacrylate (PMMA) cement spacers because it is believed to be inactivated by the high polymerization temperatures. The purpose of this study was to compare cefazolin versus vancomycin high-dose antibiotic cement spacers. METHODS: High-dose antibiotic PMMA spacers with either cefazolin or vancomycin were fabricated. Setting time, compressive strength, and compression modulus of spacers were measured...
March 1, 2023: Journal of Orthopaedic Trauma
#12
EDITORIAL
Jin Bo Tang, Grey Giddins
No abstract text is available yet for this article.
August 2022: Hand Clinics
#13
REVIEW
Grey Giddins
Although patients with obstetric brachial plexus injuries (OBPI) have been recognized and treated for greater than 100 years there is much that is not understood or is mis-understood. I address 6 areas for discussion: the cause of OBPI and whether it matters to nerve surgeons; the value of the Narakas grading; whether surgeons should perform primary nerve surgery, especially in patients with incomplete OBPI; the cause and treatment of shoulder tightness; the cause and treatment of elbow contracture; and whether patients with OBPI need surgery in adulthood...
August 2022: Hand Clinics
#14
REVIEW
Grey Giddins
Mallet injuries, either tendinous or bony, are common. They are often studied together and typically treated in the same way with extension splintage for 6 to 8 weeks. Yet the evidence clearly shows there are different injuries that present in the same way. Tendinous mallet injuries present in older patients usually following a low energy injury; they are often painless. The commonly injured fingers are the middle and ring. The injuries are almost always single digit without concomitant injuries. There is an extensor lag of a mean of 310 (range 3°-590 ) in the patients treated in my unit...
August 2022: Hand Clinics
#15
REVIEW
Panagiotis Sgardelis, Grey Giddins
Background: Silastic metacarpophalangeal joint (MCPJ) arthroplasty is a recognised treatment for painful finger arthritis. There are two commonly used, albeit different, designs; the Swanson and the NeuFlex© . Which design is optimal is unclear. The purpose of this study was to evaluate the radiological differences relative to the bones following implantation. Methods: We examined the radiological features of these implants up to 1 year of follow-up. We reviewed the postoperative radiographs of 42 patients with 113 MCPJ arthroplasties and assessed the implant body anatomical 'fit' relative to the widths of the cut metacarpals and proximal phalanges and resection lengths of the metacarpal heads...
August 2022: Journal of Hand Surgery Asian-Pacific Volume
#16
JOURNAL ARTICLE
Luke Duggleby, Lysander Gourbault, Thomas Parsons, Eleanor Boden, Tristan Barton, Grey Giddins
PURPOSE: Injury prevention is important. Injury as a result of an accident carries with it huge cost to the individual and society including health services costs. Understanding the mechanism of injury is important to identify those injuries that are preventable. The aim of this study was to assess how many acute orthopaedic injuries were preventable should reasonable human interventions have been taken METHODS: This prospective study was performed in a UK district general hospital that serves a population of 500,000 people...
August 2022: Injury
#17
JOURNAL ARTICLE
Laurine Cafarelli, Laela El Amiri, Sybille Facca, Nabil Chakfé, Marie-Cécile Sapa, Philippe Liverneaux
BACKGROUND: Surgical teaching is most often carried out in the operating theatre through mentorship, and the performance of surgical procedures is rarely measured. The objective of this article is to compare the progression in learning curves of junior surgeons trained in the anterior plating technique for the distal radius on a nonbiological model according to three different methods. METHODS: The materials comprised 12 junior surgeons of level 1 or 2 (as per Tang and Giddins) divided into three groups: control (G1), naive practice (G2), and deliberate practice (G3)...
June 7, 2022: International Orthopaedics
#18
JOURNAL ARTICLE
Alastair Kiszely, Grey Giddins
During hand surgery, tendons may be at risk of damage. This biomechanical study aims to assess the risk of tendon rupture due to passage of Kirschner wires or hypodermic needles. Porcine extensor tendons were divided into four groups. Group 1: a control group was tested to ensure that repeated stress alone did not cause failure. Group 2a: 1.1-mm Kirschner wires were hand pushed through tendons 50 times and then stressed to 40 N, repeated until tendon failure. In Group 2b, K-wires were passed while rotating using a drill...
May 2022: Journal of Hand Surgery, European Volume
#19
JOURNAL ARTICLE
Greg Thomas Pickering, Nicola Francesca Fine, Thomas David Knapper, Grey Edward Bence Giddins
Accurate assessment of distal radioulnar joint (DRUJ) stability is increasingly recognized as an important part of clinical examination of the wrist. The ability of 30 specialist UK hand surgeons to clinically determine the stability of four volunteers' wrists was assessed. Volunteers' wrist stability had previously been confirmed with a validated measurement rig. Use of the wrist ballottement test as the primary examination technique yielded a positive predictive value of 81%, a negative predictive value of 55%, a specificity of 94% and a sensitivity of only 24%, for the detection of DRUJ instability...
November 2, 2021: Journal of Hand Surgery, European Volume
#20
RANDOMIZED CONTROLLED TRIAL
James S McCarthy, Özkan Yalkinoglu, Anand Odedra, Rebecca Webster, Claude Oeuvray, Aliona Tappert, Deon Bezuidenhout, Marla J Giddins, Satish K Dhingra, David A Fidock, Louise Marquart, Lachlan Webb, Xiaoyan Yin, Akash Khandelwal, Wilhelmina M Bagchus
BACKGROUND: M5717 is the first plasmodium translation elongation factor 2 inhibitor to reach clinical development as an antimalarial. We aimed to characterise the safety, pharmacokinetics, and antimalarial activity of M5717 in healthy volunteers. METHODS: This first-in-human study was a two-part, single-centre clinical trial done in Brisbane, QLD, Australia. Part one was a double-blind, randomised, placebo-controlled, single ascending dose study in which participants were enrolled into one of nine dose cohorts (50, 100, 200, 400, 600, 1000, 1250, 1800, or 2100 mg) and randomly assigned (3:1) to M5717 or placebo...
December 2021: Lancet Infectious Diseases
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