keyword
https://read.qxmd.com/read/38461456/preliminary-evidence-for-a-positive-relation-between-the-comt-rs4680-met-met-genotype-and-math-achievement
#1
JOURNAL ARTICLE
Yaira Chamorro, Adriana P Mendizabal-Ruiz, Roberto A Abreu-Mendoza, J Alejandro Morales, María de Lourdes Ramírez-Dueñas, Esmeralda Matute
To identify if COMT polymorphisms interact with executive functions as predictors of math skills, we assessed 38 adolescents (mean age = 16.4 ± 0.80 years, IQ > 80) from a larger study of high-school students screened for their mathematical abilities. Adolescents were genotyped for the COMT Val158Met polymorphism (grouped as Met/Met or Val-carriers) and completed the WRAT math achievement test, working-memory, inhibitory-control, and shifting tasks. Met/Met-carriers achieved higher WRAT scores than the Val-carriers ( W  = 229, p  = ...
March 10, 2024: Developmental Neuropsychology
https://read.qxmd.com/read/38341445/the-influence-of-the-comt-val158met-polymorphism-on-prefrontal-tdcs-effects-on-aggression
#2
JOURNAL ARTICLE
Carmen Weidler, Lena Hofhansel, Christina Regenbogen, Dario Müller, Benjamin Clemens, Christian Montag, Andreas Reif, Ute Habel
Increasing dorsolateral prefrontal cortex (DLPFC) activity by anodal transcranial direct current stimulation (tDCS) enhances cognitive control and might reduce aggression. The Val158Met polymorphism within the catechol-O-methyltransferase gene (rs4680) plays a pivotal role in prefrontal dopamine signaling, displaying associations with aggressive behavior, and potentially influencing the effects of tDCS. In a double-blind, sham-controlled study, we investigated the influence of rs4680 on tDCS effects on aggression...
February 10, 2024: Scientific Reports
https://read.qxmd.com/read/38318385/behavioral-physiological-and-genetic-drivers-of-coping-in-a-non-human-primate
#3
JOURNAL ARTICLE
Debottam Bhattacharjee, Aníta Rut Guðjónsdóttir, Paula Escriche Chova, Esmee Middelburg, Jana Jäckels, Natasja G de Groot, Bernard Wallner, Jorg J M Massen, Lena S Pflüger
Animals experience stressful situations, from predation to social conflicts, but mostly deal with them successfully. This adaptive mechanism, coping, reduces the adverse effects of stressors, and its failure may result in reduced fitness. Substantial inter-individual variation in coping is observed, yet little is known about how behavioral, physiological and genetic drivers regulate coping holistically and contribute to such variations. We assessed behavioral coping styles (n =30 ), emotional arousal (n =12 ), and personalities (n =32 ) of long-tailed macaques ( Macaca fascicularis ) and also investigated the association of coping with a valine/methionine polymorphism encoded by a critical human stress regulatory gene, catechol- O -methyltransferase (COMT) (n =26 )...
February 16, 2024: IScience
https://read.qxmd.com/read/38228118/to-each-his-own-fear-gender-related-association-of-anxiety-substance-use-and-eating-disorders-in-a-representative-birth-cohort-sample-of-young-adults-with-either-comt-val158met-allele
#4
JOURNAL ARTICLE
Evelyn Kiive, Triin Kurrikoff, Toomas Veidebaum, Jaanus Harro
INTRODUCTION: The role of catechol-O-methyltransferase (COMT) in catecholamine neurotransmitter metabolism has led to the investigation of variants of the corresponding gene in the etiology of different psychiatric disorders, but the results are inconclusive. METHODS: We have examined the relationship between COMT Val158Met single nucleotide polymorphism (rs4680) and the occurrence of psychiatric disorders in a highly representative birth cohort sample of young adults in the Estonian Children Personality Behaviour and Health Study (original n = 1,238)...
January 16, 2024: Neuropsychobiology
https://read.qxmd.com/read/38206282/a-randomized-trial-of-the-effects-of-comt-inhibition-on-subjective-response-to-alcohol-moderation-by-baseline-comt-activity-and-mediation-of-alcohol-self-administration
#5
JOURNAL ARTICLE
Joseph P Schacht, Matthew Kubicki, Raymond F Anton
BACKGROUND: Poor inhibitory control and enhanced subjective response to alcohol are interrelated risk factors for alcohol use disorder (AUD) that share underlying neural substrates, including dopamine signaling in the right prefrontal cortex, a potential target for pharmacological intervention. Cortical dopamine inactivation is primarily regulated by catechol-O-methyltransferase (COMT), an enzyme with large variation in activity as a function of the COMT rs4680 (val158met) single nucleotide polymorphism...
January 2024: Alcohol Clin Exp Res (Hoboken)
https://read.qxmd.com/read/38027832/-comt-val-met-stressful-life-events-and-externalizing-behaviors-in-youth-a-longitudinal-study-from-the-abcd-sample
#6
JOURNAL ARTICLE
Tuana Kant, Emiko Koyama, Clement C Zai, Marcos Sanches, Joseph H Beitchman, James L Kennedy
Early adolescence is a crucial time for understanding and detecting the risk factors that may influence youth externalizing/disruptive behaviors and disorders. Previous literature reported evidence that risk factors for disruptive behaviors include catechol-O-methyltransferase ( COMT) Val158Met (rs4680) polymorphism and environmental influences. An unanswered question is whether there is a change in these risk factors over stages of youth development. This longitudinal study examines the interaction effect of Val158Met and stressful life events (SLE) on youth externalizing behaviors from ages 9-11...
November 2023: Heliyon
https://read.qxmd.com/read/38002474/the-val158met-polymorphism-in-8-year-old-boys-and-girls-moderates-the-influence-of-parenting-styles-on-proactive-aggression-testing-the-sensitivity-to-the-environment
#7
JOURNAL ARTICLE
Nora Del Puerto-Golzarri, Aitziber Azurmendi, José Manuel Muñoz, María Rosario Carreras, Eider Pascual-Sagastizabal
The aim of the study was to explore the possible vulnerability (diathesis-stress), susceptibility (differential susceptibility), or vantage (vantage sensitivity) properties of COMT gen Val158Met polymorphism to adverse and favorable parenting styles from both parents in relation to children's reactive and proactive aggressive behavior. Within 279 eight-year-old children (125 girls and 154 boys) from Spain, reactive and proactive aggressive behavior was measured through the "Reactive and Proactive Questionnaire" (RPQ)...
October 26, 2023: Brain Sciences
https://read.qxmd.com/read/37880658/association-of-drd2-drd4-and-comt-genes-variants-and-their-gene-gene-interactions-with-antipsychotic-treatment-response-in-patients-with-schizophrenia
#8
JOURNAL ARTICLE
Narges Taheri, Rokhshid Pirboveiri, Mehdi Sayyah, Mahdi Bijanzadeh, Pegah Ghandil
Antipsychotic drugs are the first line of treatment in schizophrenia; although antipsychotic responses indicate a wide interindividual variety in patients with schizophrenia. This study aimed to investigate the association between four polymorphisms in DRD2, DRD4 and COMT genes and their gene-gene interactions with antipsychotic treatment response in patients with schizophrenia. A total of 101 patients with schizophrenia were recruited and stratified in treatment responder and treatment resistant groups based on the published criteria of resistant to treatment using PANSS...
October 25, 2023: BMC Psychiatry
https://read.qxmd.com/read/37744392/the-relation-of-apoe-and-comt-gene-gene-interactions-to-cognitive-and-motor-function-in-community-dwelling-older-adults-a-pilot-study
#9
JOURNAL ARTICLE
Kendra L Pizzonia, Julie A Suhr, Leatha A Clark, Brian C Clark
INTRODUCTION: Certain genes increase the risk of age-related neurological dysfunction and/or disease. For instance, ApoE is a well-known gene carrying risk for Alzheimer's disease, while COMT has been associated with age-related reductions in motor function. There is growing interest in the interrelationship between age-related changes in cognitive and motor function, and examining gene-gene interactions in this context. In this pilot study we examined the relations of the ApoE and COMT genes and their interaction to both cognitive and motor performance in community-dwelling older adults...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37525044/cognitive-rehabilitation-for-patients-with-schizophrenia-a-narrative-review-of-moderating-factors-strategies-and-outcomes
#10
JOURNAL ARTICLE
Maria Skokou, Lambros Messinis, Grigorios Nasios, Philippos Gourzis, Euthymios Dardiotis
OBJECTIVE: Antipsychotic drugs constitute the basis of schizophrenia therapy; however, available pharmaceutical agents lack efficacy for treating the cognitive deficits caused by the illness. The aim of the present work is to present current data regarding cognitive rehabilitation of schizophrenia, providing information and guidance to health professionals. METHOD: A literature search was conducted in the PubMed and Google Scholar Databases from inception up to 1/9/2022...
2023: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/37522041/the-comt-gene-modulates-the-relationship-between-bilingual-adaptation-in-executive-function-and-decision-making-an-eeg-study
#11
JOURNAL ARTICLE
Dongxue Liu, John W Schwieter, Wenxin Liu, Li Mu, Huanhuan Liu
UNLABELLED: Bilingual adaptive control mechanisms appear to be linked to congenital genetic factors such as dopamine (DA) genes. However, it is unclear as to whether acquired cognitive exercise can vanquish innate influences that allow bilingual executive advantages to be shown in other cognitive areas. In the present study, we examine the relationship between gene-dependent executive control and decision-making by targeting the enzyme catecholamine-O-methyltransferase (COMT) and employing electroencephalography (EEG)...
August 2023: Cognitive Neurodynamics
https://read.qxmd.com/read/37305098/association-of-comt-val158met-polymorphism-with-fibromyalgia-in-khartoum-state-sudan
#12
JOURNAL ARTICLE
Safaa Mamoun Abdelmageid, Faisal Mousa Alamir, Hassan Yousif Abdelrahman, Hind Mohamed Abushama
Fibromyalgia (FM) is a disorder characterized by chronic musculoskeletal pain, fatigue, and cognitive problems. Neurotransmitters, mainly catecholamines, appear to be involved in regulating the etiology of FM. Catechol-O-methyltransferase ( COMT ) is involved in catabolizing catecholamines such as norepinephrine. The most common variant studied in the COMT gene is the valine (Val) to methionine (Met) substitution at codon 158. This is the first study in Sudan addressing FM cases and genetic susceptibility to the disease...
2023: Pain Research & Management
https://read.qxmd.com/read/37187218/comt-val158met-affects-the-analgesic-response-to-acupuncture-among-cancer-survivors-with-chronic-pain
#13
RANDOMIZED CONTROLLED TRIAL
Mingxiao Yang, Raymond E Baser, Raya Khanin, Isidora Autuori, Qing S Li, Katherine S Panageas, Irene Orlow, Jun J Mao
Catechol-O-methyltransferase (COMT) is the major enzyme involved in the catabolism of dopamine, a neurotransmitter in the brain's reward system. The common COMT polymorphism Val158Met (rs4680 G>A) modulates pain response to opioids through a reward-motivated mechanism; however, its role in nonpharmacological pain medicine has not been clinically characterized. We genotyped 325 participants from a randomized controlled trial of cancer survivors with chronic musculoskeletal pain. We found that carrying methionine at position 158 (158Met) of COMT, encoded by the A allele, significantly increased the analgesic response to electroacupuncture (74% vs 50%; odds ratio [OR]: 2...
September 2023: Journal of Pain
https://read.qxmd.com/read/37167133/-irritable-bowel-syndrome-phenotypes-leading-factors-of-genetics-and-epigenetics-mechanisms-of-formation
#14
JOURNAL ARTICLE
O V Gaus, M A Livzan
AIM: To develop individualized approaches to the treatment of irritable bowel syndrome (IBS) based on the interaction of genetic and epigenetic factors, to characterize the phenotypes of the disease. MATERIALS AND METHODS: According to the formulated concept of the authors, from the cohort of patients with IBS, subgroups were distinguished - "post-infectious IBS" ( n =45), "IBS in overweight and obese people" ( n =49), "comorbid IBS" ( n =75) and "essential IBS" ( n =51)...
March 30, 2023: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/37159230/estradiol-and-the-catechol-o-methyltransferase-gene-interact-to-predict-working-memory-performance-a-replication-and-extension
#15
JOURNAL ARTICLE
Courtney C Louis, Emily Jacobs, Mark D'Esposito, Jason Moser
Decades of evidence across taxa have established the importance of dopamine (DA) signaling in the pFC for successful working memory performance. Genetic and hormonal factors can shape individual differences in prefrontal DA tone. The catechol-o-methyltransferase (COMT) gene regulates basal prefrontal DA, and the sex hormone 17β-estradiol potentiates DA release. [Jacobs, E. G., & Goldstein, J. M. The middle-aged brain: Biological sex and sex hormones shape memory circuitry. Current Opinion in Behavioral Sciences, 23, 84-91, 2018] investigated the moderating role of estradiol on cognition using the COMT gene and COMT enzymatic activity as a proxy for pFC DA tone...
April 28, 2023: Journal of Cognitive Neuroscience
https://read.qxmd.com/read/36644316/catechol-o-methyltransferase-effects-on-smoking-a-review-and-proof-of-concept-of-sex-sensitive-effects
#16
JOURNAL ARTICLE
Elise E DeVito, Mehmet Sofuoglu
PURPOSE OF REVIEW: This article reviews recent research on how catechol- O -methyltransferase (COMT) may impact cigarette smoking behavior, and how effects may be sex-sensitive. Preliminary data are presented on sex-sensitive effects of COMT on response to short-term abstinence in individuals who smoke. RECENT FINDINGS: Although research is mixed, functional variants in the COMT gene have been linked with smoking behavior, cessation outcomes and nicotine abstinence-related symptoms...
December 2022: Current Behavioral Neuroscience Reports
https://read.qxmd.com/read/36203835/the-inconsistent-mediating-effect-of-catechol-o-methyl-transferase-val-158-met-polymorphism-on-the-sex-difference-of-cognitive-impairment-in-schizophrenia-patients
#17
JOURNAL ARTICLE
Hang Xu, Yongjie Zhou, Meihong Xiu, Dachun Chen, Weiwen Wang, Li Wang, Xiangyang Zhang
Objective: Schizophrenia is a multifaceted mental disorder characterized by heterogeneous positive/negative symptoms and cognitive deficits. Sex differences have been reported in various aspects of the disease. However, the underlying genetic reasons remain unelucidated. Recent studies show that the influence of COMT Val158Met (rs4680) variation is sexually dimorphic. Thus, this study aims to explore whether there is an effect of the interaction between COMT Val158Met (rs4680) polymorphism and sex on patients' clinical characteristics and cognitive function...
2022: Frontiers in Psychiatry
https://read.qxmd.com/read/36179810/are-comt-val158met-rs4680-drd2-taqia-rs1800497-and-bdnf-val66met-rs6265-polymorphisms-associated-with-executive-functions-performance-at-rest-and-during-physical-exercise
#18
JOURNAL ARTICLE
Dr Maicon Albuquerque
Executive functions (EFs) encompass a wide array of cognitive processes, which appear to be influenced by genetic variants of the COMT, DRD2/ANKK1, and BDNF polymorphisms. The present study aimed to investigate whether COMT Val158Met (rs4680), DRD2/ANKK1 (rs1800497), and BDNF Val66Met (rs6265) polymorphisms were associated with EFs assessed at rest and during moderate acute physical exercise. Sixty physically active individuals underwent four laboratory visits. First, they filled out the pre-exercise survey, researchers collected their anthropometric data, and then performed a maximal cardiopulmonary exercise test...
September 27, 2022: Physiology & Behavior
https://read.qxmd.com/read/36100778/working-memory-dysfunction-in-fibromyalgia-is-associated-with-genotypes-of-the-catechol-o-methyltransferase-gene-an-event-related-potential-study
#19
JOURNAL ARTICLE
David Ferrera, Francisco Gómez-Esquer, Irene Peláez, Paloma Barjola, Roberto Fernandes-Magalhaes, Alberto Carpio, María Eugenia De Lahoz, María Carmen Martín-Buro, Francisco Mercado
Recent findings have associated different COMT genotypes with working memory capacity in patients with fibromyalgia. Although it is thought that the COMT gene may influence neural correlates (P2 and P3 ERP components) underlying working memory impairment in this chronic-pain syndrome, it has not yet been explored. Therefore, the aim of the present research was to investigate the potential effect of the COMT gene in fibromyalgia patients on ERP working memory indices (P2 and P3 components). For this purpose, 102 participants (51 patients and 51 healthy control participants) took part in the experiment...
February 2023: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/36078283/parent-adolescent-conflict-depressive-symptoms-and-non-suicidal-self-injury-among-chinese-adolescents-the-moderating-effect-of-the-comt-gene-rs4680-polymorphism
#20
JOURNAL ARTICLE
Yuting Deng, Meijin Li, Huahua Wang, Jingjing Li, Xu He, Chengfu Yu
Existing research suggests that parent-adolescent conflict is associated with increased risk for adolescent non-suicidal self-injury (NSSI). However, adolescent NSSI reactions to parent-adolescent conflicts exhibit large individual differences. This study sought to explore whether depressive symptoms mediates the relationship between parent-adolescent conflict and adolescent NSSI, and whether this mediating process is moderated by the COMT gene rs4680 polymorphism. A total of 673 adolescents (364 males, 309 females) in the age range of 12 to 15 years ( Mean age = 12...
August 25, 2022: International Journal of Environmental Research and Public Health
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