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https://www.readbyqxmd.com/read/29924756/xerostomia-thirst-sodium-gradient-and-inter-dialytic-weight-gain-in-hemodialysis-diabetic-vs-non-diabetic-patients
#1
A Bruzda-Zwiech, J Szczepańska, R Zwiech
BACKGROUND: In hemodialysis (HD) patients, xerostomia and hyposalivation may intensify sensations of thirst, and contribute to the intake of fluids and excessive inter-dialytic weight gain (IWG). Since IWG is regarded to be higher in diabetic patients than in non-diabetics HD enhancing their mortality, it is crucial to define plausible underlying causes. Therefore, the study investigates factors contributing to the increased IWG in diabetic HD patients. MATERIAL AND METHODS: The study included 97 HD patients (38 diabetics) receiving hemodialysis...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924320/nutritional-status-measures-are-correlated-with-pupillary-responsiveness-in-zambian-children
#2
Katherine Healy, Amanda C Palmer, Maxwell A Barffour, Kerry J Schulze, Ward Siamusantu, Justin Chileshe, Keith P West, Alain B Labrique
Background: Impairments in visual function have been well characterized in vitamin A deficiency. However, eye function may also be sensitive to other nutrient deficiencies. Objective: We examined associations between visual function-characterized by pupillary threshold or pupillary responsiveness-and nutritional status in Zambian children. Methods: We used digital pupillometry to measure visual responses to calibrated light stimuli (-2.9 to 0...
June 19, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29924240/clinical-trial-for-uniform-multidrug-therapy-for-leprosy-patients-in-brazil-u-mdt-ct-br-adverse-effects-approach
#3
Rossilene Conceição da Silva Cruz, Samira Bührer-Sékula, Gerson Oliveira Penna, Maria Elisabete Amaral de Moraes, Heitor de Sá Gonçalves, Mariane Martins de Araújo Stefani, Maria Lúcia Fernandes Penna, Maria Araci de Andrade Pontes, Sinésio Talhari
BACKGROUND: The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE: Describe adverse effects due to MDT in U-MDT/CT-BR, comparing the uniform regimen (U-MDT) to the current WHO regimen (R-MDT). PATIENTS AND METHODS: After operational classification, patients were randomly allocated to the study groups...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923941/intensive-care-mortality-prognostic-model-for-pediatric-pulmonary-hypertension
#4
Emily Morell Balkin, Matt S Zinter, Satish K Rajagopal, Roberta L Keller, Jeffrey R Fineman, Martina A Steurer
OBJECTIVES: The disease burden and mortality of children with pulmonary hypertension are significantly higher than for the general PICU population. We aimed to develop a risk-adjustment tool predicting PICU mortality for pediatric pulmonary hypertension patients: the Pediatric Index of Pulmonary Hypertension Intensive Care Mortality score. DESIGN: Retrospective analysis of prospectively collected multicenter pediatric critical care data. SETTING: One-hundred forty-three centers submitting data to Virtual Pediatric Systems database between January 1, 2009, and December 31, 2015...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29923445/provider-related-linkages-between-primary-care-clinics-and-community-based-senior-centers-associated-with-diabetes-related-outcomes
#5
Polly Hitchcock Noël, Chen-Pin Wang, Erin P Finley, Sara E Espinoza, Michael L Parchman, Mary J Bollinger, Helen P Hazuda
The Institute of Medicine (IOM) suggests that linkages between primary care practices and community-based resources can improve health in lower income and minority patients, but examples of these are rare. We conducted a prospective, mixed-methods observational study to identify indicators of primary care-community linkage associated with the frequency of visits to community-based senior centers and improvements in diabetes-related outcomes among 149 new senior center members (72% Hispanic). We used semistructured interviews at baseline and 9-month follow-up, obtaining visit frequency from member software and clinical assessments including hemoglobin A1c (HbA1c) from colocated primary care clinics...
June 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29923286/efficacy-and-safety-of-the-glucagon-receptor-antagonist-pf-06291874-a-12-week-randomized-dose-response-study-in-patients-with-type-2-diabetes-mellitus-on-background-metformin-therapy
#6
David J Kazierad, Kristin Chidsey, Veena R Somayaji, Arthur J Bergman, Roberto A Calle
AIMS: To conduct a dose-response assessment of the efficacy and safety of the glucagon receptor antagonist PF-06291874 in adults with type 2 diabetes (T2DM) receiving stable doses of metformin. MATERIALS AND METHODS: This randomized, double-blind, statin-stratified, placebo-controlled, 4-arm, parallel-group study was conducted in patients with T2DM receiving background metformin. After an 8-week, non-metformin oral antidiabetic agent washout period, 206 patients were randomized to placebo or PF-06291874 (30, 60, or 100 mg once daily) for 12 weeks...
June 19, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29922144/differential-entropy-preserves-variational-information-of-near-infrared-spectroscopy-time-series-associated-with-working-memory
#7
Soheil Keshmiri, Hidenubo Sumioka, Ryuji Yamazaki, Hiroshi Ishiguro
Neuroscience research shows a growing interest in the application of Near-Infrared Spectroscopy (NIRS) in analysis and decoding of the brain activity of human subjects. Given the correlation that is observed between the Blood Oxygen Dependent Level (BOLD) responses that are exhibited by the time series data of functional Magnetic Resonance Imaging (fMRI) and the hemoglobin oxy/deoxy-genation that is captured by NIRS, linear models play a central role in these applications. This, in turn, results in adaptation of the feature extraction strategies that are well-suited for discretization of data that exhibit a high degree of linearity, namely, slope and the mean as well as their combination, to summarize the informational contents of the NIRS time series...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29922111/how-does-the-utilization-of-diabetes-dietitian-and-educator-service-in-saudi-arabia-affect-glycemic-outcomes
#8
Saad M Alshareef, Mujahed A Alkhathlan, Abdullah A Alwabel, Abdulkarim A Al-Bawardi, Abdulrahman H Alqarni, Ali S Almuryidi, Ibrahim N Altuwaim, Monther Khalid Alhabib, Omar A Almuzaini, Turki S Alqahtani
BACKGROUND: Despite the acknowledgment that the services of diabetes educator and dietician affect outcome, the level of utilization of these services in the Saudi Arabian public health-care system is not known. The aims of the study were to establish the percentage of patients with diabetes mellitus (DM) followed up by a diabetic educator and a dietician in a tertiary center in Saudi Arabia and associations between follow-up by a diabetic educator and a dietician and glycemic control...
May 2018: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/29922047/relationship-between-high-sensitivity-cardiac-troponin-t-and-the-prognosis-of-elderly-inpatients-with-non-acute-coronary-syndromes
#9
Wei Wu, Dong-Xia Li, Qing Wang, Ying Xu, Yun-Jing Cui
Objective: Low-level high-sensitivity cardiac troponin T (hs-cTnT) increases in elderly population. In this study, the relationship between hs-cTnT level and all-cause death of elderly inpatients with non-acute coronary syndrome (non-ACS) after discharge from the hospital was investigated. Materials and methods: Non-ACS patients aged >65 years admitted in the General Practice Wards and Department of Geriatrics of Fuxing Hospital Affiliated to Capital Medical University were enrolled in the study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29921991/sickle-cell-hemoglobin-c-disease-patient-undergoing-coronary-artery-bypass-grafting-with-complete-exchange-blood-transfusion-during-cardiopulmonary-bypass
#10
Francesca Mullins, Shawn Ott, Nakia Mister, Jeffrey Travis
Sickle cell disorders are associated with increased risk of sickling and vaso-occlusive complications when undergoing cardiopulmonary bypass (CPB) surgery. Monitoring of certain parameters such as venous and arterial oxygen content, hematocrit, acid base homeostasis, and body temperature are required for a superior outcome. Furthermore, perioperative exchange transfusion has a positive effect on the outcome of surgery and on the survival of patients undergoing heart surgery. Avoiding intraoperative hypoxia and hypothermia, and minimizing hemoglobin S (HbS) and hemoglobin C (HbC) levels with exchange transfusion make bypass surgery relatively safe with enhanced outcomes in these cases...
June 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29921987/plasma-free-hemoglobin-generation-using-the-eos-pmp-%C3%A2-oxygenator-and-the-centrimag-%C3%A2-blood-pump
#11
Ashley B Hodge, Matthew A Deitemyer, Victoria L Duffy, Dmitry Tumin, Dorothy A Garbin, Kathleen K Nicol, Don Hayes, Mary J Cismowski, Andrew R Yates
Hemolysis is a known consequence of extracorporeal membrane oxygenation (ECMO) resulting from shear force within the different components of the extracorporeal circuit. The primary aim of this study was to evaluate the EOS PMP™ oxygenator for generation of plasma free hemoglobin (PfHg) over 24 hours at nominal operating range flow rates. The EOS ECMO™ (LivaNova, Inc.; formerly Sorin, Arvada, CO) is equipped with a plasma tight polymethylpentene (PMP) hollow fiber oxygenator. We hypothesized that PfHg generation would be elevated in circuits with higher flow rates, because of the significant pressure drop across the oxygenator according to manufacturer provided flow charts...
June 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29921985/high-molecular-weight-von-willebrand-factor-multimer-loss-and-bleeding-in-patients-with-short-term-mechanical-circulatory-support-devices-a-case-series
#12
Michael Goldfarb, Lawrence S Czer, Lee D Lam, Jaime Moriguchi, Francisco A Arabia, Oksana Volod
Acquired von Willebrand syndrome (VWS) due to loss of high-molecular-weight multimers (HMWMs) has been reported with longer term mechanical devices and is associated with mucosal bleeding, a primary hemostasis type of bleeding. However, little is known whether a similar defect occurs in patients with short-term mechanical circulatory support (STMCS) devices. We reviewed von Willebrand factor (VWF) profiles in patients with STMCS devices who underwent VWS workup from December 2015 to March 2017 at an academic quaternary care hospital...
June 2018: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29921734/intravenous-epoetin-alfa-epbx-versus-epoetin-alfa-for-treatment-of-anemia-in-end-stage-kidney-disease
#13
Steven Fishbane, Bhupinder Singh, Seema Kumbhat, Wayne A Wisemandle, Nancy E Martin
BACKGROUND AND OBJECTIVES: This study was conducted to compare the safety and efficacy of intravenous epoetin alfa-epbx, an epoetin alfa biosimilar, to epoetin alfa in patients on hemodialysis with ESKD and anemia. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In this 24-week, multicenter, double-blind comparative efficacy and safety study, 612 patients on hemodialysis with ESKD and anemia who had stable hemoglobin and were receiving stable doses of intravenous epoetin alfa were randomized (1:1) to intravenous epoetin alfa or epoetin alfa-epbx...
June 19, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29921477/quality-of-evidence-based-guidelines-for-transfusion-of-red-blood-cells-and-plasma-a-systematic-review
#14
REVIEW
Katerina Pavenski, Simon Stanworth, Mark Fung, Erica M Wood, Joanne Pink, Michael F Murphy, Heather Hume, Susan Nahirniak, Kathryn E Webert, Susano Tanael, Denise Landry, Nadine Shehata
Many transfusion guidelines are available, but little appraisal of their quality has been undertaken. The quality of guidelines may potentially influence adoption. Our aim was to determine the quality of evidence-based transfusion guidelines (EBG) for red cells and plasma, using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument, and assess duplication and consistency of recommendations. MEDLINE and EMBASE were systematically searched for EBG from 2005 to June 3, 2016. Citations were reviewed for inclusion in duplicate...
June 1, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29920886/blood-catalyzed-raft-polymerization
#15
Amin Reyhani, Mitchell D Nothling, Hadi Ranji-Burachaloo, Thomas G McKenzie, Qiang Fu, Shereen Tan, Gary Bryant, Greg G Qiao
The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition-fragmentation chain transfer (RAFT) process is reported for the first time. No pre-treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Due to the naturally-occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules...
June 19, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29920582/early-mucosal-healing-predicts-favorable-outcomes-in-patients-with-moderate-to-severe-ulcerative-colitis-treated-with-golimumab-data-from-the-real-life-be-smart-cohort
#16
Peter Bossuyt, Filip Baert, Francois D'Heygere, Antoine Nakad, Catherine Reenaers, Fernand Fontaine, Denis Franchimont, Olivier Dewit, Philippe Van Hootegem, Stijn Vanden Branden, Guy Lambrecht, Marc Ferrante
Background: Golimumab (GOL) is registered for moderate to severely active ulcerative colitis (UC). Data on the use of GOL in daily clinical practice are limited. Currently, it is unclear which factors are predictive of a favorable outcome. The goals of this study were to evaluate the mid-term outcome of GOL (week 26) in patients with moderate to severe UC and to determine predictors of favorable outcome. Methods: Patients included in the SMART study (NCT02155335) were evaluated for their mid-term outcome...
June 15, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29920505/characteristics-of-adolescents-referred-to-a-gender-clinic-are-youth-seen-now-different-from-those-in-initial-reports
#17
Lyne N Chiniara, Herbert J Bonifacio, Mark R Palmert
BACKGROUND/AIMS: To examine characteristics, including mental health comorbidities, among adolescents presenting to a transgender clinic and to compare these data to previous reports. METHODS: Retrospective chart review among youth seen at The Hospital for Sick Children between January 2014 and June 2016. Demographic data, clinical characteristics, and mental health comorbidities were assessed. Baseline and repeat blood work were also examined. RESULTS: Charts from 203 adolescents aged 12-18 years were reviewed (156 assigned female at birth [AFAB] (77%) aged 16...
June 19, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29920341/high-and-low-affinity-pegylated-hemoglobin-based-oxygen-carriers-differential-oxidative-stress-in-a-guinea-pig-transfusion-model
#18
Esra'a Ali Mohammad Alomari, Luca Ronda, Stefano Bruno, Gianluca Paredi, Marialaura Marchetti, Stefano Bettati, Davide Olivari, Francesca Fumagalli, Deborah Novelli, Giuseppe Ristagno, Roberto Latini, Chris E Cooper, Brandon J Reeder, Andrea Mozzarelli
Hemoglobin (Hb)-based oxygen carriers (HBOCs) are an investigational replacement for blood transfusions and are known to cause oxidative damage to tissues. To investigate the correlation between their oxygen binding properties and these detrimental effects, we investigated two PEGylated HBOCs endowed with different oxygen binding properties - but otherwise chemically identical - in a Guinea pig transfusion model. Plasma samples were analyzed for biochemical markers of inflammation, tissue damage and organ dysfunction; proteins and lipids of heart and kidney extracts were analyzed for markers of oxidative damage...
June 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29920116/predictors-and-moderators-of-antipsychotic-related-weight-gain-in-the-treatment-of-early-onset-schizophrenia-spectrum-disorders-study
#19
Jerome H Taylor, Ewgeni Jakubovski, Daniel Gabriel, Michael H Bloch
BACKGROUND: Antipsychotic-related weight gain is a common clinically relevant side effect when treating psychotic disorders in pediatric populations, yet few predictors and no moderators of antipsychotic-related weight gain are known. METHODS: The Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study randomized 119 youths (age 8-19 years) with schizophrenia or schizoaffective disorder to 8 weeks of antipsychotic treatment with molindone, risperidone, or olanzapine and assessed treatment response and side effects...
June 19, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29917215/effects-of-micronised-dispersible-ferric-pyrophosphate-combined-with-alpha-lactalbumin-in-pregnant-women-affected-by-iron-deficiency-anemia-results-from-a-prospective-double-blind-randomized-controlled-trial
#20
A S Laganà, L Costabile, P Filati, M Noventa, A Vitagliano, R D'Anna
OBJECTIVE: This study aimed at evaluating the effects obtained by administering 30 mg of micronised dispersible ferric pyrophosphate plus 300 mg of alpha-lactalbumin (MDFP-AL) compared to 80 mg of ferrous gluconate (FG) in pregnant women affected by iron-deficiency anemia (IDA). PATIENTS AND METHODS: We considered eligible all second-trimester singleton pregnancies in women affected by IDA. We excluded any other disease, twin pregnancies, any other pharmacologic/nutraceutical treatments (besides folic acid) before/during pregnancy...
June 2018: European Review for Medical and Pharmacological Sciences
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