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Bipolar depression II

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https://www.readbyqxmd.com/read/28531646/lifetime-presence-of-psychotic-symptoms-in-bipolar-disorder-is-associated-with-less-favorable-socio-demographic-and-certain-clinical-features
#1
Bernardo Dell'Osso, Giulia Camuri, Laura Cremaschi, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The presence of psychotic symptoms in bipolar disorder (BD) is considered a feature of higher severity of illness and, in particular, of manic episodes in bipolar I disorder (BD I). However, the possibility to apply the "with psychotic features" specifier to major depressive episodes in either bipolar II disorder (BD II) or BD I highlights the need for additional research in this area. METHODS: The present study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of BD patients (N=360), with (BDPs, N=207) and without a lifetime history of psychosis (BDNPs, N=153)...
April 21, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28528241/peripheral-zinc-and-neopterin-concentrations-are-associated-with-mood-severity-in-bipolar-disorder-in-a-gender-specific-manner
#2
Caitlin E Millett, Dahlia Mukherjee, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T Postolache, Shannon L Kelleher, Erika F H Saunders
Bipolar disorder (BD) is a recurrent, episodic mood disorder for which there are no current diagnostic, prognostic or theranostic biomarkers. Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. Given gender differences in clinical presentation of BD and in inflammatory processes, we aimed to explore the interaction between gender and immune biomarkers to predict mood severity in BD. Participants with DSM IV BD I and II were recruited through the Pennsylvania Psychiatric Institute during an acute mood episode...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28507774/footnotes-to-kraepelin-changes-in-the-classification-of-mood-disorders-with-dsm-5
#3
EDITORIAL
Nicola J Kalk, Allan H Young
SUMMARY: Reliable diagnosis of mood disorders continues to pose a challenge. This is surprising because they have been recognised clinically since classical times. Mood disorders are also common: major depressive disorder affects nearly 300 million people worldwide and bipolar affective disorder nearly 60 million and they are a major cause of disability. Nonetheless, the reliability trials of the updated Diagnostic and Statistical Manual, Fifth Edition (DSM-5) found that the reliability of the diagnosis of major depressive disorder was in the 'questionable' range...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28506220/does-the-number-of-previous-mood-episodes-moderate-the-relationship-between-alcohol-use-smoking-and-mood-in-bipolar-outpatients
#4
Wendela G Ter Meulen, Jan van Zaane, Stasja Draisma, Aartjan T F Beekman, Ralph W Kupka
BACKGROUND: Evidence suggests that alcohol use and smoking are negatively associated with mood in bipolar disorders (BD). It is unknown if this relationship is moderated by the number of previous mood episodes. Therefore, this paper aims to examine whether the number of previous mood episodes moderates the relationship between alcohol use and smoking, and mood. METHOD: This study assessed the outcomes of 108 outpatients with BD I and II in a prospective observational cohort study...
May 15, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28503106/depression-and-mania-in-bipolar-disorder
#5
Leonardo Tondo, Gustavo H Vázquez, Ross J Baldessarini
BACKGROUND: Episode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not well defined for subtypes of the disorder. METHODS: We reviewed the course, timing, and duration of episodes of mania and depression among 1130 clinically treated DSM-IV-TR BD patients of various types, and compared duration and rates as well as total proportion of time in depressive versus manic episodes during 16.7 average years at risk...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28493605/adverse-effects-of-obesity-on-cognitive-functions-in-individuals-at-ultra-high-risk-for-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#6
Roger S McIntyre, Rodrigo B Mansur, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
BACKGROUND: The burden of illness associated with bipolar disorder (BD) warrants early pre-emption/prevention. Prediction models limited to psychiatric phenomenology have insufficient predictive power. Herein, we aimed to evaluate whether the presence of overweight/obesity is associated with greater cognitive decline in individuals at high risk (HR) or ultra high risk (UHR) for BD. METHODS: We conducted a retrospective analysis to investigate the moderational role of body mass index (BMI) on measures of cognitive function...
March 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28486308/effect-of-n-desalkylquetiapine-quetiapine-plasma-level-ratio-on-anxiety-and-depression-in-bipolar-disorder-a-prospective-observational-study
#7
C Rovera, M C Mauri, C Di Pace, S Paletta, A Reggiori, V Ciappolino, D Cattaneo, S Baldelli, E Clementi, A C Altamura
BACKGROUND: The aim of this study was to analyse the relationships between quetiapine and N-desalkylquetiapine plasma levels and clinical improvement, particularly, in regard to depressive and anxious symptoms and to hostility. METHODS: This was a prospective observational study that involved 37 outpatients diagnosed as having bipolar disorder I or II. All the patients were observed during a clinical acute and postacute phase. Patients were prescribed 50-800 mg of quetiapine...
May 5, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28480482/long-term-response-to-mood-stabilizer-treatment-and-its-clinical-correlates-in-patients-with-bipolar-disorders-a-retrospective-observational-study
#8
Sung Woo Ahn, Ji Hyun Baek, So-Yung Yang, Yongkang Kim, Youngah Cho, Yujin Choi, Kounseok Lee, Taesung Park, Kyung Sue Hong
BACKGROUND: The efficacy and utility of long-term prophylactic treatment in patients with bipolar disorders (BDs) have not been fully explored. This study aims to estimate the long-term clinical response of patients with BDs to mood stabilizer treatment and to identify the clinical factors associated with that response. METHODS: The study subjects consisted of 80 patients with bipolar I or bipolar II disorder who had been receiving treatment with lithium and/or valproate for more than 2 years at a single bipolar disorder clinic...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28474733/practitioner-review-the-effects-of-atypical-antipsychotics-and-mood-stabilisers-in-the-treatment-of-depressive-symptoms-in-paediatric-bipolar-disorder
#9
REVIEW
Tobias Atkin, Nicolas Nuñez, Gabriella Gobbi
BACKGROUND: The management of depressive and mixed symptoms in children and adolescents with bipolar disorder (BD) remains a matter of debate. The goal of this review is, thus, to systematically examine the impact of atypical antipsychotics (AAPs) and mood stabilisers in the treatment of bipolar depression and/or mixed states. METHODS: A literature search was conducted for studies assessing the efficacy of pharmacological treatments for bipolar disorder type I, type II and not otherwise specified with a recent depressive, mixed or manic episode (with depressive symptoms) following DSM-IV criteria in children and adolescents as either acute or maintenance treatment...
May 5, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28472082/efficacy-of-cognitive-behavioral-therapy-in-patients-with-bipolar-disorder-a-meta-analysis-of-randomized-controlled-trials
#10
Kai-Jo Chiang, Jui-Chen Tsai, Doresses Liu, Chueh-Ho Lin, Huei-Ling Chiu, Kuei-Ru Chou
BACKGROUND: Although cognitive behavioral therapy (CBT) is considered a promising adjuvant to pharmacotherapy for treating bipolar disorder (BD), its efficacy is unproven. The present review and meta-analysis evaluated the treatment outcomes of patients with BD treated with CBT plus medication and compared these data with the outcomes of those who received standard care alone. METHODS: Electronic searches from inception to July 31, 2016, were performed using PubMed, Medline OVID, Cochrane Library, EMBASE, CINAHL plus, and PsycINFO...
2017: PloS One
https://www.readbyqxmd.com/read/28468681/personality-traits-in-bipolar-disorder-and-influence-on-outcome
#11
Timea Sparding, Erik Pålsson, Erik Joas, Stefan Hansen, Mikael Landén
BACKGROUND: The aim was to investigate the personality profile of bipolar disorder I and II, and healthy controls, and to study whether personality influences the course of bipolar disorder. METHODS: One hundred ten patients with bipolar disorder I, 85 patients with bipolar disorder II, and 86 healthy individuals had their personality profile assessed using the Swedish universities Scales of Personality (SSP), an instrument developed to explore personality-related vulnerabilities and correlates of psychiatric disorders...
May 3, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28437059/psychotic-and-bipolar-disorders-bipolar-disorder
#12
Sarah D Holder
Bipolar disorder is a severe chronic mental illness that affects a large number of individuals. This disorder is separated into two major types, bipolar I disorder, with mania and typically recurrent depression, and bipolar II disorder, with recurrent major depression and hypomania. Patients with bipolar disorder spend the majority of time experiencing depression, and this typically is the presenting symptom. Because outcomes are improved with earlier diagnosis and treatment, physicians should maintain a high index of suspicion for bipolar disorder...
April 2017: FP Essentials
https://www.readbyqxmd.com/read/28427032/social-cognition-in-bipolar-disorder-focus-on-emotional-intelligence
#13
C Varo, E Jimenez, B Solé, C M Bonnín, C Torrent, E Valls, I Morilla, G Lahera, A Martínez-Arán, E Vieta, M Reinares
BACKGROUND: The present study aims to characterize emotional intelligence (EI) variability in a sample of euthymic bipolar disorder (BD) patients through the Mayer- Salovey-Caruso Emotional Intelligence Test (MSCEIT). METHOD: A total of 134 euthymic BD outpatients were recruited and divided into three groups according to the total Emotional Intelligence Quotient (EIQ) score of the MSCEIT, following a statistical criterion of scores 1.5SDs above/below the normative group mean, as follows: a low performance (LP) group (EIQ <85), a normal performance (NP) group (85≤EIQ≤115), and a high performance (HP) group (EIQ >115)...
April 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28410446/self-reported-long-term-benefits-of-mindfulness-based-cognitive-therapy-in-patients-with-bipolar-disorder
#14
Béatrice Weber, Loretta Sala, Marianne Gex-Fabry, Aurélie Docteur, Philip Gorwood, Paolo Cordera, Guido Bondolfi, Françoise Jermann, Jean-Michel Aubry, Christine Mirabel-Sarron
OBJECTIVES: This study focused on patients with bipolar disorder (BD), several years after their participation in mindfulness-based cognitive therapy (MBCT). It aimed at documenting sustained mindfulness practice, perceived long-term benefit from the program, and changes regarded as direct consequences of the intervention. DESIGN: This cross-sectional survey took place at least 2 years after MBCT for 70.4% of participants. LOCATION: It was conducted in two specialized outpatient units for BDs that are part of the Geneva University Hospitals (Switzerland) and the Sainte-Anne Hospital in Paris (France)...
April 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28399092/-the-affective-pathology-in-patients-with-adolescent-bulimia-nervosa
#15
V V Grachev
AIM: To investigate affective pathology in patients with adolescent bulimia nervosa (BN) and to analyze comorbid mutual influences of these clinical entities. MATERIAL AND METHODS: A sample consisted of 52 young female patients, aged from 13.9 to 17.4 years, who simultaneously meet ICD-10 criteria of F50.2 - typical BN and F30-F39 - mood disorders. The Eating Attitudes Test (EAT-26) and the Beck Depression Inventory were used for psychometric assessment. Duration of follow-up ranged from 1 to 7 years...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28390496/kindling-of-life-stress-in-bipolar-disorder-effects-of-early-adversity
#16
Benjamin G Shapero, Rachel B Weiss, Taylor A Burke, Elaine M Boland, Lyn Y Abramson, Lauren B Alloy
Most theoretical frameworks regarding the role of life stress in bipolar disorders (BD) do not incorporate the possibility of a changing relationship between psychosocial context and episode initiation across the course of the disorder. The kindling hypothesis theorizes that over the longitudinal course of recurrent affective disorders, the relationship between major life stressors and episode initiation declines (Post, 1992). The present study aimed to test an extension of the kindling hypothesis in BD by examining the effect of early life adversity on the relationship between proximal life events and prospectively assessed mood episodes...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28390495/aggression-protects-against-the-onset-of-major-depressive-episodes-in-individuals-with-bipolar-spectrum-disorder
#17
Tommy H Ng, Rachel D Freed, Madison K Titone, Jonathan P Stange, Rachel B Weiss, Lyn Y Abramson, Lauren B Alloy
A growing body of research suggests that bipolar spectrum disorders (BSDs) are associated with high aggression. However, little research has prospectively examined how aggression may affect time to onset of hypomanic/manic versus major depressive episodes. In a longitudinal study, we tested the hypothesis that aggression would prospectively predict a shorter time to the onset of hypomanic/manic episodes and a longer time to the onset of major depressive episodes, based on the behavioral approach system theory of BSDs...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28381796/correlation-between-the-efficacy-of-lamotrigine-and-the-serum-lamotrigine-level-during-the-remission-phase-of-acute-bipolar-ii-depression-a-naturalistic-and-unblinded-prospective-pilot-study
#18
Akiyoshi Kikkawa, Yoshihisa Kitamura, Tetsuya Aiba, Koichi Hiraki, Toshiaki Sendo
Lamotrigine has acute antidepressant effects in patients with bipolar disorder. However, there is little information regarding appropriate serum levels of lamotrigine and the time until remission after the start of lamotrigine therapy in patients with bipolar II depression. This was a naturalistic and unblinded prospective pilot study. Twelve patients' depressive symptoms were evaluated using the Montgomery-Åsberg Depression Rating Scale (MADRS) at the start of treatment and at the time of remission, and blood samples were obtained at the time of remission...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28368159/personality-disorder-symptom-severity-predicts-onset-of-mood-episodes-and-conversion-to-bipolar-i-disorder-in-individuals-with-bipolar-spectrum-disorder
#19
Tommy H Ng, Taylor A Burke, Jonathan P Stange, Patricia D Walshaw, Rachel B Weiss, Snezana Urosevic, Lyn Y Abramson, Lauren B Alloy
Although personality disorders (PDs) are highly comorbid with bipolar spectrum disorders (BSDs), little longitudinal research has been conducted to examine the prospective impact of PD symptoms on the course of BSDs. The aim of this study is to examine whether PD symptom severity predicts shorter time to onset of bipolar mood episodes and conversion to bipolar I disorder over time among individuals with less severe BSDs. Participants (n = 166) with bipolar II disorder, cyclothymia, or bipolar disorder not otherwise specified completed diagnostic interview assessments of PD symptoms and self-report measures of mood symptoms at baseline...
April 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28365522/longitudinal-course-and-characteristics-of-cyclothymic-disorder-in-youth
#20
Anna R Van Meter, Eric A Youngstrom, Boris Birmaher, Mary A Fristad, Sarah M Horwitz, Thomas W Frazier, L Eugene Arnold, Robert L Findling
OBJECTIVES: Epidemiological studies suggest that cyclothymic disorder is the most prevalent subtype of bipolar disorder (BD). However, it is rarely diagnosed, especially in youth. This may be because it can be difficult to ascertain whether a youth meets diagnostic criteria. Clearer, easy-to-apply criteria could reduce misdiagnosis. The objective oftable this study was to determine whether proposed research diagnostic criteria for cyclothymic disorder (RDCyc), based on DSM-5 criteria, could be quantified and validated in youth...
June 2017: Journal of Affective Disorders
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