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Acute pancreatitis severity scores

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https://www.readbyqxmd.com/read/28225011/early-spontaneous-abdominal-bleeding-is-associated-with-poor-outcome-in-moderate-to-severe-acute-pancreatitis-patients-a-propensity-matched-study
#1
Yizhe Chen, Jing Zhou, Gang Li, Zhihui Tong, Jie Dong, Yiyuan Pan, Lu Ke, Weiqin Li, Jieshou Li
Abdominal bleeding is a lethal complication in acute pancreatitis (AP) and it is commonly described as a late event. However, spontaneous intra-abdominal bleeding could occur very early but no study focusing on this phenomenon was published yet. In this study, 1137 AP patients were retrospectively screened and 24 subjects suffering early spontaneous bleeding (ESB) were selected. Meanwhile, a 1:1 well-balanced cohort of non-bleeding patients was generated by propensity score match. The clinical characteristics of these patients were compared and a multiple regression analysis was performed to assess the risk factors for ESB...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218693/propylene%C3%A2-glycol%C3%A2-alginate%C3%A2-sodium%C3%A2-sulfate%C3%A2-alleviates%C3%A2-cerulein-induced%C3%A2-acute%C3%A2-pancreatitis%C3%A2-by%C3%A2-modulating%C3%A2-the%C3%A2-mek-erk%C3%A2-pathway%C3%A2-in%C3%A2-mice
#2
Hui Zhang, Yueyue Li, Linqiang Li, Hua Liu, Liangkai Hu, Ying Dai, Jianqing Chen, Shuqi Xu, Weimin Chen, Xiaorong Xu, Xuanfu Xu
Previous studies have focused on the effects of propylene glycol alginate sodium sulfate  (PSS)  against  thrombosis,  but  the  anti-inflammatory  potential  is  unknown.  Therefore,  we  specifically focused on the protective effects of PSS on cerulein-induced acute pancreatitis (AP)  using a mouse model, and investigated the mechanism of PSS on autophagy and apoptosis via the  Mitogen-activated  protein  kinase  (MEK)/extracellular  signal-regulated  kinase  (ERK)  pathway...
February 17, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28209258/biliary-tract-external-drainage-protects-against-multiple-organs-injuries-of-severe-acute-pancreatitis-rats-via-heme-oxygenase-1-upregulation
#3
Jin-Long Wang, Ying Chen, Xiao-Qing Song, Mei-Ling Lu, Bing Zhao, Li Ma, Er-Zhen Chen, En-Qiang Mao
OBJECTIVE: To investigate the effect of biliary tract external drainage (BTED) on severe acute pancreatitis (SAP) in rats and the relationship with heme oxygenase-1 (HO-1) pathway. METHODS: Thirty SD rats weighing 250-300 g were randomly assigned into five groups (n = 6): sham surgery (SS) group, SAP group, SAP + BTED group, SAP + zinc protoporphyrin IX (ZnPP) group, SAP + BTED + ZnPP group. The SAP model was induced via retrograde injection of 4% sodium taurocholate (1 mL/kg) into biliopancreatic duct through duodenal wall...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28207167/bisap-ranson-lactate-and-others-biomarkers-in-prediction-of-severe-acute-pancreatitis-in-a-european-cohort
#4
Francisco Valverde-López, Ana M Matas-Cobos, Carlos Alegría-Motte, Rita Jiménez-Rosales, Margarita Úbeda-Muñoz, Eduardo Redondo-Cerezo
BACKGROUND AND AIM: Assessing and comparing the predicting ability of some scores and biomarkers in Acute Pancreatitis (AP). METHODS: We prospectively collected data from 269 patients diagnosed of AP, admitted to Virgen de las Nieves University Hospital between June 2010 and June 2012. Blood urea nitrogen (BUN), C-reactive protein (CRP) and creatinine (Cr) were measured on admission and after 48 hours, lactate and BISAP only on admission and RANSON within the first 48 hours...
February 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28205445/severe-hypertriglyceridemia-induced-by-sirolimus-treated-with-medical-management-without-plasmapheresis
#5
Kazuhiko Kido, Rickey A Evans, Anil Gopinath, Jeremy D Flynn
: Hypertriglyceridemia and hyperlipidemia are the most remarkable metabolic complications seen with long-term sirolimus therapy. We report the case of a 36-year-old woman status post bilateral lung transplantation on a maintenance immunosuppression regimen of sirolimus, tacrolimus, and prednisone who presented with status migrainosus, chest pain, abdominal discomfort, and triglyceride levels greater than 4425 mg/dL. In previously reported cases of severe hypertriglyceridemia that developed on maintenance sirolimus therapy, plasmapheresis has been utilized as an early strategy to rapidly lower triglycerides in order to minimize the risk of acute complications such as pancreatitis, but our case was managed medically without plasmapheresis...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28190685/impact-of-body-fat-and-muscle-distribution-on-severity-of-acute-pancreatitis
#6
Seung Bae Yoon, Moon Hyung Choi, In Seok Lee, Chul-Hyun Lim, Jin Soo Kim, Yu Kyung Cho, Jae Myung Park, Bo-In Lee, Young-Seok Cho, Myung-Gyu Choi
BACKGROUND/OBJECTIVES: Obesity is a well-established risk factor for severe acute pancreatitis (AP); however, the impact of visceral obesity or sarcopenic obesity on severity of AP has not been well studied. We compared the relationship between severity of AP and various body parameters including body weight, body mass index (BMI), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and visceral fat-to-muscle ratio (VMR). METHODS: We analyzed the data of patients who were diagnosed with AP from 2009 to 2015...
February 6, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28183420/circulating-microrna-216-as-a-marker-for-the-early-identification-of-severe-acute-pancreatitis
#7
Xiao-Xin Zhang, Li-Hui Deng, Wei-Wei Chen, Na Shi, Tao Jin, Zi-Qi Lin, Yun Ma, Kun Jiang, Xiao-Nan Yang, Qing Xia
BACKGROUND: To study the value of circulating microRNA 216 (miR-216) as a marker for the severity of acute pancreatitis (AP) in both murine models and patients. MATERIALS AND METHODS: Mice with AP were induced by intraperitoneal injection of 50μg/kg/hour cerulean either 7 times, sacrificed at 8, 9, 10, 11 or 12 hours after the first injection, or 12 times, sacrificed at 24 hours after the first injection. Plasma samples and data from patients with AP were obtained from a prospective cohort...
February 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28181127/role-of-bedside-pancreatic-scores-and-c-reactive-protein-in-predicting-pancreatic-fluid-collections-and-necrosis
#8
Doraiswami Babu Vinish, Vishnu Abishek, K Sujatha, S Arulprakash, Rajkumar Solomon, P Ganesh
BACKGROUND: Acute pancreatitis is a disease with variable outcome; the course of the disease can be modified by early aggressive management in patients with severe pancreatitis. Easily calculable pancreatic scores and investigations can help to triage these patients. We aimed to determine the role of bedside index for severity in acute pancreatitis (BISAP), harmless acute pancreatitis score (HAPS), and systemic inflammatory response syndrome (SIRS) scores on day of admission and C-reactive protein (CRP) at 48 h for predicting the presence of pancreatic fluid collection (PFC) and necrosis on CT scans done at 72 h...
February 9, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28164588/elevated-presepsin-levels-are-associated-with-severity-and-prognosis-of-severe-acute-pancreatitis
#9
Jianbo Lin, Zhe Li, Yanhong Zheng, Yang Zhang, Cunhua Shao, Gongpan Liu, Jiangong Li
BACKGROUND: Current clinical scoring systems are insufficient in the early identification of severe acute pancreatitis (SAP) patients at risk of developing potentially lethal complications. This present study was designed to evaluate the relationship of presepsin with disease severity, local complications, organ failure, and mortality of SAP. METHODS: Eighty-five SAP patients and 85 gender- and age-matched healthy volunteers were enrolled. Presepsin concentrations were measured on admission from SAP patients and at study entry from healthy individuals...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28144728/-acute-pancreatitis-in-intensive-care-medicine-which-risk-score-is-useful
#10
A J Fischer, F Andreottola, P Lenz, P Lebiedz
INTRODUCTION: Acute pancreatitis is a disease with an increasing incidence in the Western countries associated with a high mortality depending on severity of disease. Etiology is often biliary or due to alcoholism. Incidence of etiology varies between regions depending on risk-factor prevalence. Several risk scores are available to estimate mortality. The aim of the study is to identify the risk factors most relevant for patients being treated for severe acute pancreatitis in an ICU of a tertiary medical center...
January 31, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28125855/predictors-and-outcomes-of-acute-pancreatitis-in-critically-ill-patients-presenting-to-the-emergency-department-of-a-tertiary-referral-centre-in-australia
#11
Krishnaswamy Sundararajan, Tom Schoeman, Lara Hughes, Suzanne Edwards, Benjamin Reddi
OBJECTIVE: To provide a current review of the clinical characteristics, predictors and outcomes in critically ill patients presenting to the ED with acute pancreatitis and subsequently admitted to an intensive care unit (ICU) of a tertiary referral centre in Australia. METHODS: A retrospective single-centre study of adult patients admitted with pancreatitis. Severe acute pancreatitis defined by Bedside Index of Severity in Acute Pancreatitis (BISAP) score ≥2. RESULTS: Eighty-seven patients fulfilled criteria for inclusion during the study period, representing 0...
January 26, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28057899/retrospective-evaluation-of-circulating-thyroid-hormones-in-critically-ill-dogs-with-systemic-inflammatory-response-syndrome
#12
Massimo Giunti, Roberta Troia, Mara Battilani, Luciana Giardino, Francesco Dondi, Giulia Andreani, Federico Fracassi
Critical illness can be associated with transient alterations in circulating thyroid hormones concentration indicating Non-Thyroidal Illness (NTI). NTI is well described in humans; literature concerning its occurrence and prognostic significance in dogs remains limited. The aim of this retrospective study was to assess the occurrence of NTI in a population of dogs with Systemic Inflammatory Response Syndrome (SIRS), and to investigate its association with disease severity (Apple Fast Score). A total of 41 SIRS dogs (acute pancreatitis n=10; parvovirus n=22; septic peritonitis n=9) were included, and divided according to SIRS origin (non-septic SIRS: acute pancreatitis; septic-SIRS: parvovirus and septic peritonitis) and final outcome (survivors, n=37; non-survivors, n=4)...
January 4, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28050922/abdominal-paracentesis-drainage-improves-tolerance-of-enteral-nutrition-in-acute-pancreatitis-a-randomized-controlled-trial
#13
Liang Hongyin, Huang Zhu, Wang Tao, Lin Ning, Liu Weihui, Cui Jianfeng, Yan Hongtao, Tang Lijun
OBJECTIVE: The objective of this study is to determine whether abdominal paracentesis drainage (APD) could improve the administration of enteral nutrition (EN) in acute pancreatitis. METHODS: Between January 2015 and April 2016, a total of 161 acute pancreatitis patients were enrolled and randomly assigned to either the APD group or the non-APD group. Several indexes associated with the administration of EN, including the gastroparesis cardinal symptom index (GCSI), the incidence of gastrointestinal adverse events, and the clinical outcomes, were recorded...
April 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28043308/diagnostic-accuracy-of-modified-ct-severity-index-in-assessing-severity-of-acute-pancreatitis
#14
Amna Rehan, Zonaira Shabbir, Asim Shaukat, Osman Riaz
OBJECTIVE: To determine the diagnostic accuracy of modified CT severity index in assessing the severe acute pancreatitis keeping APACHE II as gold standard. STUDY DESIGN: Cross-sectional (validation) study. PLACE AND DURATION OF STUDY: Department of Radiology, Allied Hospital, Faisalabad, from February to August 2014. METHODOLOGY: A total of 120 patients of either gender aged 20-60 years with epigastric pain radiating to back and having sonographic findings (decreased or heterogeneous pancreatic echogenicity, pancreatic enlargement, peripancreatic fluid collection), supportive of acute pancreatitis were taken...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28013317/determination-of-serum-neutrophil-gelatinase-associated-lipocalin-at-the-early-stage-of-acute-pancreatitis
#15
Mateusz Sporek, Paulina Dumnicka, Agnieszka Gala-Błądzińska, Małgorzata Mazur-Laskowska, Jerzy Walocha, Piotr Ceranowicz, Zygmunt Warzecha, Artur Dembiński, Marek Kuźniewski, Rafał Olszanecki, Beata Kuśnierz-Cabala
AIM: e aim of the study was to assess the diagnostic value of serum concentrations of neutrophil gelatinase-associated lipocalin (sNGAL) for the determination of the severity of acute pancreatitis (AP) at the early stage of the disease. MATERIALS AND METHOD: The study group consisted of 65 patients(34 men and 31 women),aged 62.2 ± 16.0, admitted to the Surgery Department of the District Hospital in Sucha Beskidzka, Poland, with the diagnosis of AP according to the revised Atlanta classification (2012)...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28009683/diabetes-mellitus-is-associated-with-mortality-in-acute-pancreatitis
#16
Ji Hye Huh, Hosung Jeon, Sun Min Park, EunHee Choi, Geun Sook Lee, Jae Woo Kim, Kyong Joo Lee
BACKGROUND AND AIM: Predicting severe pancreatitis is important for early aggressive management of patients with acute pancreatitis (AP). Despite the established role of diabetes mellitus (DM) in the risk of AP, the impact of DM on the clinical outcome in AP has not been fully elucidated. The objective of this study was to assess the risk of mortality and severity in AP among patients with type-2 DM. METHODS: Patients diagnosed with first attacks of AP were enrolled from January 2013 to June 2015...
December 22, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28007685/early-prediction-of-organ-failure-under-the-revised-atlanta-classification
#17
Jian Liu, Feng Cao, Xiao Min Dong, Peng Yu Li, Hai Chao Li, Bao Ju Qi, Fei Li
BACKGROUND/AIMS: This study aimed to compare the ability of conventional laboratory markers and scoring systems to early predict organ failure (OF) and to differentiate between transient and persistent OF in patients with acute pancreatitis (AP) using the revised Atlanta classification. MATERIALS AND METHODS: We retrospectively analyzed the medical records of 214 patients with AP between January 2014 and July 2015. The predictive values of laboratory markers were analyzed...
January 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27929426/serum-soluble-fms-like-tyrosine-kinase-1-sflt-1-predicts-the-severity-of-acute-pancreatitis
#18
Paulina Dumnicka, Mateusz Sporek, Małgorzata Mazur-Laskowska, Piotr Ceranowicz, Marek Kuźniewski, Ryszard Drożdż, Tadeusz Ambroży, Rafał Olszanecki, Beata Kuśnierz-Cabala
Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27920277/the%C3%A2-diffuse%C3%A2-reduction%C3%A2-of%C3%A2-spleen%C3%A2-density-%C3%A2-an%C3%A2-indicator%C3%A2-of%C3%A2-severe%C3%A2-acute%C3%A2-pancreatitis
#19
Guangdong Shao, Yanmei Zhou, Zengfu Song, Maitao Jiang, Xiaoqian Wang, Xiangren Jin, Bei Sun, Xuewei Bai
BACKGROUND: We observed that acute pancreatitis (AP) was associated with diffuse reduction of spleen density (DROSD) in some patients. Furthermore, the condition of these patients was more serious, and the potential relationship between DROSD and structural and functional injury of the spleen remained unclear. Therefore, we performed a preliminary exploration of these factors. METHODS: We analysed pertinent clinical data for AP patients with normal spleen density (control group) and for those with DROSD (reduction group) at the First Affiliated Hospital of Harbin Medical University (2013...
December 5, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27914940/soluble-urokinase-type-plasminogen-activator-receptor-supar-in-patients-with-acute-pancreatitis-ap-progress-in-prediction-of-ap-severity
#20
Michal Lipinski, Alicja Rydzewska-Rosolowska, Andrzej Rydzewski, Malgorzata Cicha, Grazyna Rydzewska
BACKGROUND: Soluble urokinase-type plasminogen activator receptor (suPAR) is a glycoprotein secreted during inflammation and infections. Moreover, increased levels of suPAR are observed after hypoxia and ischaemia. The aim of the study was to assess whether suPAR could represent a useful marker of acute pancreatitis (AP) severity. PATIENTS AND METHODS: We have observed a cohort of 126 prospectively enrolled patients. Based on the presence of persistent organ failure (more than 48 h) and local complications (diagnosis of moderate AP [MSAP]), patients were classified into three groups: mild AP (MAP), moderate and severe AP (SAP)...
November 25, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
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