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Acute pancreatitis severity scores

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https://www.readbyqxmd.com/read/29115648/correlation-between-ischemia-modified-albumin-and-ranson-score-in-acute-pancreatitis
#1
Cem Emir Güldoğan, Murat Özgür Kılıç, İlhan Balamir, Mesut Tez, Turan Turhan
BACKGROUND: Although Ranson score is the most commonly used prognostic model in the severity of acute pancreatitis (AP), ischemia-modified albumin (IMA) has been reported as a novel biomarker of various ischemia-based diseases in recent years. The aim of the present study is to investigate the correlation between Ranson score and IMA in patients with AP. METHODS: Forty-three patients with AP were included in the study. All patients were classified as mild and severe AP...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29095423/association-of-statins-with-decreased-acute-pancreatitis-severity-a-propensity-score-analysis
#2
Peter J Lee, Kunjam Modha, Tiffany Chua, Amitabh Chak, Daniel Jang, Rocio Lopez, Amir Gougol, Georgios I Papachristou, Tyler Stevens
BACKGROUND: Statins possess anti-inflammatory properties and have a protective effect in certain inflammatory conditions; however, their effect on the natural history of pancreatitis is unknown. AIM: The aim of this study is to assess the effect of statin exposure on the severity of pancreatitis and incidence of organ failure using a propensity-matched approach. METHODS: A historical cohort study was conducted of adult patients with acute pancreatitis (AP) admitted in the Cleveland Clinic Health System between 2007 and 2014...
October 31, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29082890/acute-pancreatitis-after-coronary-artery-bypass-surgery-treated-by-plasmapheresis
#3
Emine Şeyma Denli Yalvaç, Mustafa Aldağ, Cemal Kocaaslan, Ebubekir Şenateş, Ebuzer Aydın
Acute pancreatitis (AP) is a common disorder and an important cause of morbidity and mortality. There are different causes of AP, including gallstones and excessive alcohol consumption. AP after coronary artery bypass grafting (CABG) surgery is seen less frequently but it is associated with a high mortality rate due to its atypical and misleading symptoms. Supportive treatment, pain management, and treatment of complications are used in the treatment of AP. The treatment of hypertriglyceridemia-induced pancreatitis is plasmapheresis, which is an extracorporeal separation of blood components to assist in the removal of inflammatory mediators...
October 30, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29067525/hypernatremia-and-acute-pancreatitis-in-chronic-kidney-disease-back-to-the-salt-mines-questions
#4
Marie de Tersant, Thérésa Kwon, Marie-Alice Macher, Anne Maisin, Georges Deschênes, Olivier Niel
BACKGROUND: Acute pancreatitis can be a life-threatening complication in patients with chronic kidney disease (CKD), especially in kidney transplant recipients. CASE DIAGNOSIS/TREATMENT: The patient was 7 years old when he received renal transplantation for CKD secondary to posterior urethral valves. Two years later, he presented with severe necrotizing pancreatitis (Ranson's score 5, Balthazar's score 8). Viral and genetic testing came back negative; pancreatitis was attributed to the patient's treatments (prednisone, trimethoprim-sulfamethoxazole, and everolimus)...
October 24, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29062479/murine-genotype-impacts-pancreatitis-severity-and-systemic-inflammation-an-experimental-study
#5
Gabriel J Seifert, Karoline C Sander, Sabine Richter, Uwe A Wittel
BACKGROUND: Little is known regarding the impact of host response in acute pancreatitis. Here, we induce murine necrotizing pancreatitis in 9 different mouse strains. MATERIALS AND METHODS: We examined 9 different mouse strains: Balb/CB4J, C3H/HEJ, NOD/SHILT, A/J, AKR/J, C57BI/6J, DBA/2J, FVB/NJ, 129S1/SvlmJ. 10 animals per strain were randomly allotted to two groups. Sterile necrotizing pancreatitis was induced by injection of taurocholate into the common bile duct...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29056120/effects-of-erdosteine-on-experimental-acute-pancreatitis-model
#6
Banu Karapolat, Sami Karapolat, Emin Gurleyik, Mehmet Yasar
OBJECTIVE: To create acute pancreatitis condition experimentally in rats using cerulein, and to reveal histopathological effects in pancreatic tissue with erdosteine. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Department of General Surgery, Duzce University, Turkey, from June to October 2014. METHODOLOGY: Thirty male Wistar albino rats were divided into three groups. No procedures were applied to Group 1...
October 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28987680/diagnosing-acute-pancreatitis-clinical-and-radiological-characterisation-of-patients-without-threefold-increase-of-serum-lipase
#7
Maxim Avanesov, Anastassia Löser, Sarah Keller, Julius M Weinrich, Azien Laqmani, Gerhard Adam, Murat Karul, Jin Yamamura
OBJECTIVES: Diagnosing acute pancreatitis (AP) may be challenging in patients with acute abdominal pain but missing threefold increased serum lipase levels (Lip-). This studyaims both to characterize these patients using clinical, radiological and mortality data, and to assess the group of patients who need contrast-enhanced computed tomography (CECT). METHODS: In this retrospective, IRB approved study 234 consecutive patients with AP were investigated. Inclusion criteria were single (SAP) and recurrent attacks (RAP) of AP and CECT ≥72h after onset of symptoms...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28984788/concurrent-diabetic-ketoacidosis-in-hypertriglyceridemia-induced-pancreatitis-how-does-it-affect-the-clinical-course-and-severity-scores
#8
Yuchen Wang, Bashar M Attar, Keiki Hinami, Palashkumar Jaiswal, John Erikson Yap, Radhika Jaiswal, Kalpit Devani, Carlos Roberto Simons-Linares, Melchor V Demetria
OBJECTIVES: Concurrent diabetic ketoacidosis (DKA) is highly prevalent in patients with hypertriglyceridemia-induced pancreatitis (HP). Diabetic ketoacidosis could potentially complicate the diagnosis, management, and prognosis of HP. This study aimed to directly compare the clinical course of HP with and without DKA and assess the outcomes of frequently used severity-prediction scores in such population. METHODS: We retrospectively analyzed 140 patients with HP; 37 patients (26...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28944325/comparison-of-contrast-enhanced-ct-with-diffusion-weighted-mri-in-the-evaluation-of-patients-with-acute-biliary-pancreatitis
#9
Mehmet İlhan, Muhammet Üçüncü, Ali Fuat Kaan Gök, Gizem Öner, Elidor Agolli, Bahar Canbay, Barış Bakır, Recep Güloğlu, Cemalettin Ertekin
OBJECTIVE: The aim of this study was to compare contrast-enhanced computed tomography with diffusion-weighted magnetic resonance imaging in the evaluation of patients with acute biliary pancreatitis. MATERIAL AND METHODS: Fifty-three patients diagnosed with acute biliary pancreatitis, between February 2012 and July 2015, were evaluated using diffusion-weighted magnetic resonance imaging and magnetic resonance cholangiopancreatography to explain the elevation of cholestasis enzymes and bilirubin levels at "stanbul University...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28918932/building-and-verifying-a-severity-prediction-model-of-acute-pancreatitis-ap-based-on-bisap-mews-and-routine-test-indexes
#10
Jiang-Feng Ye, Yu-Xin Zhao, Jian Ju, Wei Wang
PURPOSE: To discuss the value of the Bedside Index for Severity in Acute Pancreatitis (BISAP), Modified Early Warning Score (MEWS), serum Ca2+, similarly hereinafter, and red cell distribution width (RDW) for predicting the severity grade of acute pancreatitis and to develop and verify a more accurate scoring system to predict the severity of AP. METHODS: In 302 patients with AP, we calculated BISAP and MEWS scores and conducted regression analyses on the relationships of BISAP scoring, RDW, MEWS, and serum Ca2+ with the severity of AP using single-factor logistics...
October 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28915220/predicting-the-severity-of-acute-pancreatitis-with-red-cell-distribution-width-at-early-admission-stage
#11
Ting Zhang, Hua Liu, Dongyan Wang, Pengfei Zong, Changfeng Guo, Feng Wang, Deqing Wu, Maochun Tang, Jianjun Zhou, Yan Zhao
Red cell distribution width (RDW) has been proposed as an early prognosis marker with increased mortality in variety of pathophysiological conditions. We hypothesized that elevated RDW could be used in judging the severity of acute pancreatitis (AP). We retrospectively and prospectively studied 545 and 72 AP patients, who were admitted to the Shanghai Tenth People's Hospital of Tongji University, respectively. Compared with mild acute pancreatitis, significantly higher RDW was observed in patients with moderately severe acute pancreatitis and sever acute pancreatitis (14...
September 14, 2017: Shock
https://www.readbyqxmd.com/read/28888465/predicting-and-evaluation-the-severity-in-acute-pancreatitis-using-a-new-modeling-built-on-body-mass-index-and-intra-abdominal-pressure
#12
Yang Fei, Kun Gao, Jianfeng Tu, Wei Wang, Guang-Quan Zong, Wei-Qin Li
OBJECT: Acute pancreatitis (AP) keeps as severe medical diagnosis and treatment problem. Early evaluation for severity and risk stratification in patients with AP is very important. Some scoring system such as acute physiology and chronic health evaluation-II (APACHE-II), the computed tomography severity index (CTSI), Ranson's score and the bedside index of severity of AP (BISAP) have been used, nevertheless, there're a few shortcomings in these methods. The aim of this study was to construct a new modeling including intra-abdominal pressure (IAP) and body mass index (BMI) to evaluate the severity in AP...
June 3, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28878366/the-utility-of-neutrophil-to-lymphocyte-ratio-and-fluid-sequestration-as-an-early-predictor-of-severe-acute-pancreatitis
#13
Chaoqun Han, Jun Zeng, Rong Lin, Jun Liu, Wei Qian, Zhen Ding, Xiaohua Hou
It is important to identify the patients with high-risk progression to develop severe acute pancreatitis (SAP). The study was to assess whether neutrophil to lymphocyte ratio (NLR) and fluid sequestration (FS) could represent useful markers for predicting the severity. A total of 1639 patients who underwent clinical diagnosis of AP was performed. Various serologic and clinical parameters on admission were investigated. Chronologic change in NLR and FS were analyzed, and theirs utility for predicting severity of AP was evaluated by receiver operator characteristic (ROC) curve analysis...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28876645/is-hiv-status-relevant-in-acute-pancreatitis
#14
L A Prodehl, M B Brand, M Mauser
BACKGROUND: HIV positivity and antiretroviral (ARV) treatment have been described as significant causes of acute pancreatitis prevalence and predictors of poor outcomes. Most data are from the late 1990s and early 2000s, prior to widespread roll out of ARVs and newer agents. This study assessed if there is still a significant difference between HIV positive (HIV+) and negative(HIV-) patients in acute pancreatitis in the presentation and outcomes of acute pancreatitis. METHOD: A retrospective review of a prospectively collected database of patient admission data...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28840381/early-abdominal-imaging-remains-over-utilized-in-acute-pancreatitis
#15
COMPARATIVE STUDY
David X Jin, Julia Y McNabb-Baltar, Shadeah L Suleiman, Bechien U Wu, Ramin Khorasani, Thomas L Bollen, Peter A Banks, Vikesh K Singh
BACKGROUND: Early abdominal computed tomography (CT) or magnetic resonance (MR) imaging is common in acute pancreatitis (AP). Guidelines (2007-2013) indicate routine use is unwarranted. AIMS: To compare the frequency and evaluate the predictors of early CT/MR utilization for AP between September 2006-2007 (period A) and September 2014-2015 (period B). METHODS: AP patients presenting directly to a large academic emergency department were prospectively enrolled during each period...
October 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28839444/clinical-outcomes-of-isolated-renal-failure-compared-to-other-forms-of-organ-failure-in-patients-with-severe-acute-pancreatitis
#16
Amir Gougol, Mohannad Dugum, Anwar Dudekula, Phil Greer, Adam Slivka, David C Whitcomb, Dhiraj Yadav, Georgios I Papachristou
AIM: To assess differences in clinical outcomes of isolated renal failure (RF) compared to other forms of organ failure (OF) in patients with severe acute pancreatitis (SAP). METHODS: Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ (2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28815220/severity-and-outcomes-of-acute-alcoholic-pancreatitis-in-cannabis-users
#17
Hemant Goyal, Kelsey Guerreso, Betsy Smith, Kaitlin Harper, Sheetal Patel, Akash Patel, Puja Parikh
BACKGROUND: Cannabis is the most commonly and widely used illicit drug in the world and is also the most commonly used drug of abuse in alcohol drinkers. Experimental studies have shown conflicting results of the effects of cannabis on the severity of acute pancreatitis (AP). The purpose of this study is to ascertain the clinical effects of simultaneous alcohol and cannabis use on severity at presentation and outcomes of acute alcoholic pancreatitis (AAP). METHODS: A retrospective review was conducted on the patients discharged with principle or secondary diagnosis of AP using ICD-9 & ICD-10 codes during the time period from January 2006 to December 2015 at a large community-based hospital in Central Georgia...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28751922/clinical-effect-of-electroacupuncture-on-lung-injury-patients-caused-by-severe-acute-pancreatitis
#18
Li Li, Jianbo Yu, Rui Mu, Shuan Dong
This study aimed to investigate the effects of electroacupuncture at the Lieque, Chize, and Zusanli points in patients with lung injury caused by severe acute pancreatitis. Patients with acute respiratory distress syndrome (ARDS) induced by severe acute pancreatitis (SAP) were randomly divided into three groups based on the treatment: conventional therapy alone (group A), electroacupuncture of nonacupoints with conventional therapy (group B), and electroacupuncture at the Lieque (LU7), Chize (LU5), and Zusanli (ST36) points (group C) once a day for 5 days...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28734720/rectal-nonsteroidal-anti-inflammatory-drugs-administration-is-effective-for-the-prevention-of-post-ercp-pancreatitis-an-updated-meta-analysis-of-randomized-controlled-trials
#19
Chong Yang, Yanting Zhao, Wentao Li, Shikai Zhu, Hongji Yang, Yu Zhang, Xi Liu, Nan Peng, Ping Fan, Xin Jin
BACKGROUND: Acute pancreatitis is one of the most common complications of endoscopic retrograde cholangiopancreatography (ERCP). Whether the prophylactic administration of rectal non-steroidal anti-inflammatory drugs (NSAIDs) peri-ERCP is effective in preventing post-ERCP pancreatitis (PEP) remains controversial. The aim of this study was to assess the effect of rectal NSAIDs on PEP. METHODS: A systematic search of literature databases (Cochrane Library, PubMed, EMBASE, and Web of Science) was performed to identify eligible randomized controlled trials (RCTs)...
September 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28710987/the-long-term-quality-of-life-in-patients-with-persistent-inflammation-immunosuppression-and-catabolism-syndrome-after-severe-acute-pancreatitis-a-retrospective-cohort-study
#20
Na Yang, Baiqiang Li, Bo Ye, Lu Ke, Faxi Chen, Guotao Lu, Fangfang Jiang, Zhihui Tong, Jieshou Li, Weiqin Li
PURPOSE: To explore clinical characteristics and long-term quality of life (QOL) in severe acute pancreatitis (SAP) patients with persistent inflammation-immunosuppression and catabolism syndrome (PICS). MATERIALS AND METHODS: SAP patients admitted to ICU were eligible for the retrospective cohort study if they needed prolonged intensive care (>14days). Post-ICU QOL was assessed by a questionnaire, including 36-item Short Form Health Survey (SF-36) and record of re-work in a long-term follow-up...
July 8, 2017: Journal of Critical Care
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