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Acute pancreatitis scales

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https://www.readbyqxmd.com/read/27776171/analysis-of-research-activity-in-gastroenterology-pancreatitis-is-in-real-danger
#1
Andrea Szentesi, Emese Tóth, Emese Bálint, Júlia Fanczal, Tamara Madácsy, Dorottya Laczkó, Imre Ignáth, Anita Balázs, Petra Pallagi, József Maléth, Zoltán Rakonczay, Balázs Kui, Dóra Illés, Katalin Márta, Ágnes Blaskó, Alexandra Demcsák, Andrea Párniczky, Gabriella Pár, Szilárd Gódi, Dóra Mosztbacher, Ákos Szücs, Adrienn Halász, Ferenc Izbéki, Nelli Farkas, Péter Hegyi
OBJECTIVE: Biomedical investment trends in 2015 show a huge decrease of investment in gastroenterology. Since academic research usually provides the basis for industrial research and development (R&D), our aim was to understand research trends in the field of gastroenterology over the last 50 years and identify the most endangered areas. METHODS: We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965-2015 period. Overall, 1,554,325 articles were analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27609674/acute-pancreatitis-in-icu-secondary-to-treatment-with-tigecycline
#2
A Bernas Albeniz, D A Aveiga Valencia, L Etxeberria Zabala, J Zaldibar-Gerrikagoitia Bilbao, L Aguilera Celorrio
Tigecycline is a broad spectrum antimicrobial agent, structurally similar to minocycline and that shares some tetracycline-related side effects. A case report is presented on a 68-year-old female who received tigecycline for a sepsis of unknown origin and who, in the following 5days, developed abdominal pain and elevated pancreatic enzymes, which suggested acute pancreatitis. After ruling out other origins, and according to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of the acute pancreatitis, a complication that has been reported 5 times in the database of the Spanish pharmacosurveillance system since 2009...
September 5, 2016: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/27567613/eq-5d-health-utility-scores-data-from-a-comprehensive-canadian-cancer-centre
#3
Hiten Naik, Doris Howell, Susie Su, Xin Qiu, M Catherine Brown, Ashlee Vennettilli, Margaret Irwin, Vivien Pat, Hannah Solomon, Tian Wang, Henrique Hon, Lawson Eng, Mary Mahler, Henry Thai, Valerie Ho, Wei Xu, Soo Jin Seung, Nicole Mittmann, Geoffrey Liu
BACKGROUND: To improve the precision of health economics analyses in oncology, reference datasets of health utility (HU) scores are needed from cancer survivors across different disease sites. These data are particularly sparse amongst Canadian survivors. METHODS: A survey was completed by 1759 ambulatory cancer survivors at the Princess Margaret Cancer Centre which contained demographic questions and the EuroQol-5D (EQ-5D) instrument. Clinical information was abstracted from electronic records and HU scores were calculated using Canadian health state valuations...
August 27, 2016: Patient
https://www.readbyqxmd.com/read/27536890/uncovering-factors-related-to-pancreatic-beta-cell-function
#4
Aoife M Curran, Miriam F Ryan, Elaine Drummond, Eileen R Gibney, Michael J Gibney, Helen M Roche, Lorraine Brennan
AIM: The incidence of type 2 diabetes has increased rapidly on a global scale. Beta-cell dysfunction contributes to the overall pathogenesis of type 2 diabetes. However, factors contributing to beta-cell function are not clear. The aims of this study were (i) to identify factors related to pancreatic beta-cell function and (ii) to perform mechanistic studies in vitro. METHODS: Three specific measures of beta-cell function were assessed for 110 participants who completed an oral glucose tolerance test as part of the Metabolic Challenge Study...
2016: PloS One
https://www.readbyqxmd.com/read/27466225/safe-administration-of-docetaxel-after-weekly-paclitaxel-induced-acute-pancreatitis
#5
Jean-Philippe Adam, Philippe Gauthier, Nathalie Letarte
Acute pancreatitis is an inflammatory process of the pancreas that can be mild to severe. It requires biochemical or radiologic evidence to establish the diagnosis. Only few chemotherapy agents are directly linked to acute pancreatitis. In this case report, we describe a patient who developed a mild acute pancreatitis on weekly paclitaxel with a positive dechallenge and rechallenge. A 57-year-old woman with advanced ovarian cancer started chemotherapy with carboplatin (AUC 5 every three weeks) and weekly paclitaxel (80 mg/m(2) on days 1, 8, and 15)...
July 27, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27459482/-early-diagnosis-of-mild-acute-pancreatitis
#6
A V Popov, D A Mineev, A I Ershova, N N Popova
AIM: to analyze the efficacy of early detection of patients with mild acute pancreatitis. MATERIAL AND METHODS: 61 patients with acute pancreatitis who do not require intensive care were analyzed. Severity of condition was assessed using integral scales, i.e. modified index of severe pancreatitis severity (MITOP), BISAP, HAPS, SOFA, SIRS, CTSI and Atlanta classification (2012). RESULTS: Verification of mild course of disease according to MITOP scores ≤0...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27350832/management-of-acute-pancreatitis-ap-polish-pancreatic-club-recommendations
#7
Mariusz Rosołowski, Michał Lipiński, Marek Dobosz, Marek Durlik, Stanisław Głuszek, Katarzyna Kuśnierz, Paweł Lampe, Ewa Małecka-Panas, Ewa Nowakowska-Duława, Magdalena Nowak-Niezgoda, Barbara Radomańska, Renata Talar-Wojnarowska, Urszula Wereszczyńska-Siemiątkowska, Grażyna Rydzewska
The presented recommendations concern the current management of acute pancreatitis. The recommendations relate to the diagnostics and treatment of early and late phases of acute pancreatitis and complications of the disease taking into consideration surgical and endoscopic methods. All the recommendations were subjected to voting by the members of the Working Group of the Polish Pancreatic Club, who evaluated them every single time on a five-point scale, where A means full acceptance, B means acceptance with a certain reservation, C means acceptance with a serious reservation, D means rejection with a certain reservation and E means full rejection...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/27336312/improving-the-outcome-of-acute-pancreatitis
#8
Marco J Bruno
Acute pancreatitis (AP) is the most common indication for hospital admission and its incidence is rising. It has a variable prognosis, which is mainly dependent upon the development of persistent organ failure and infected necrotizing pancreatitis. In the past few years, based on large-scale multicenter randomized trials, some novel insights regarding clinical management have emerged. In patients with infected pancreatic necrosis, a step-up approach of percutaneous catheter drainage followed by necrosectomy only when the patient does not improve, reduces new-onset organ failure and prevents the need for necrosectomy in about a third of patients...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27257696/the-american-association-for-the-surgery-of-trauma-grading-scale-for-16-emergency-general-surgery-conditions-disease-specific-criteria-characterizing-anatomic-severity-grading
#9
Gail T Tominaga, Kristan L Staudenmayer, Shahid Shafi, Kevin M Schuster, Stephanie A Savage, Steven Ross, Peter Muskat, Nathan T Mowery, Preston Miller, Kenji Inaba, Mitchell Jay Cohen, David Ciesla, Carlos V R Brown, Suresh Agarwal, Michel B Aboutanos, Garth H Utter, Marie Crandall
No abstract text is available yet for this article.
September 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27226718/triglyceride-rich-lipoproteins-as-a-causal-factor-for-cardiovascular-disease
#10
REVIEW
Peter P Toth
Approximately 25% of US adults are estimated to have hypertriglyceridemia (triglyceride [TG] level ≥150 mg/dL [≥1.7 mmol/L]). Elevated TG levels are associated with increased cardiovascular disease (CVD) risk, and severe hypertriglyceridemia (TG levels ≥500 mg/dL [≥5.6 mmol/L]) is a well-established risk factor for acute pancreatitis. Plasma TG levels correspond to the sum of the TG content in TG-rich lipoproteins (TRLs; ie, very low-density lipoproteins plus chylomicrons) and their remnants. There remains some uncertainty regarding the direct causal role of TRLs in the progression of atherosclerosis and CVD, with cardiovascular outcome studies of TG-lowering agents, to date, having produced inconsistent results...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27011518/evaluation-of-pain-preoperatively-and-postoperatively-in-patients-with-chronic-pancreatitis-undergoing-longitudinal-pancreaticojejunostomy
#11
K R Seetharam Bhat, Monty Khajanchi, Ram Prajapati, R R Satoskar
Chronic pancreatitis is a fairly common condition with pain being the major symptom, and longitudinal pancreaticojejunostomy (LPJ) is performed for symptomatic relief. The aim of the study is to assess relief of pain post-LPJ for chronic pancreatitis and to evaluate the factors influencing relief of symptoms. A prospective observational non-interventional study enrolling 28 patients. This study involved a questionnaire studying various risk factors and pain related to chronic pancreatitis, pancreaticojejunostomy, and postoperative assessment of pain relief at 1 and 6 months from surgery...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26833744/exposure-response-analyses-of-liraglutide-3-0%C3%A2-mg-for-weight-management
#12
J P H Wilding, R V Overgaard, L V Jacobsen, C B Jensen, C W le Roux
AIMS: Liraglutide 3.0 mg, an acylated GLP-1 analogue approved for weight management, lowers body weight through decreased energy intake. We conducted exposure-response analyses to provide important information on individual responses to given drug doses, reflecting inter-individual variations in drug metabolism, absorption and excretion. METHODS: We report efficacy and safety responses across a wide range of exposure levels, using data from one phase II (liraglutide doses 1...
May 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/26817330/-prediction-of-severe-acute-pancreatitis-selected-prognostic-scales-and-laboratory-markers-useful-in-the-early-stage-of-the-disease
#13
REVIEW
Mateusz Sporek, Witold Kolber, Michał Pedziwiatr, Marek Kuźniewski, Jerzy Walocha, Beata Kuśnierz-Cabala
Early diagnosis of severe acute pancreatitis with its early complications, ie. acute acute respiratory failure, acute kidney injury, or abdominal compartment syndrome, leading to the development of multiple organ failure remains crucial for the survival. It allows for precise selection of high risk patients and enables an early implementation of adequate therapy. The aim of the study was to analyze the current information on potentially useful prognostic scales and markers in the early stage of severe acute pancreatitis...
2015: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/26817077/-prognostic-significance-of-elements-of-the-multiorgan-insufficiency-syndrome-and-estimation-of-the-patients-state-severity-in-accordance-to-integral-scales-in-an-acute-necrotic-pancreatitis
#14
I V Khomyak, O V Rotar, V I Rotar, G G Petrovskiy
There were examined 113 patients, in whom an acute necrotic pancreatitis was diagnosed. While admittance to hospital a constant organ insufficiency was revealed in 50 (44%), a transient one--in 63 (56%) patients. In total 31 (27.4%) patients died. Respiratory insufficiency have occurred in 67% patients, and almost with similar rate--cardio-vascular (in 59%), renal (in 56%) and enteral (in 54%), dominating in the lethality structure. The BISAP (Bedcide Index for Severity in Acute Pancreatitis) scales applied permit with high probability to prognosticate the organ insufficiency and lethality in patients, suffering an acute necrotic pancreatitis...
September 2015: Klinichna Khirurhiia
https://www.readbyqxmd.com/read/26717383/relationship-between-acute-benzodiazepine-poisoning-and-acute-pancreatitis-risk-a-population-based-cohort-study
#15
Geng-Wang Liaw, Dong-Zong Hung, Wei-Kung Chen, Cheng-Li Lin, I-Ching Lin, Chia-Hung Kao
We designed a population-based retrospective cohort study to investigate the association between the event of benzodiazepine (BZD) poisoning and the risk of acute pancreatitis.In the present study, 12,893 patients with BZD poisoning during 2000 to 2011 were enrolled and matched with 4 comparison patients according to mean age and sex. We determined the cumulative incidences and adjusted hazard ratios of acute pancreatitis.A significant association was observed between BZD poisoning and acute pancreatitis. After adjustment for potential risk factors, the patients with BZD poisoning had a 5...
December 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26709417/a-mathematical-model-of-the-pathogenesis-prevention-and-reversal-of-type-2-diabetes
#16
Joon Ha, Leslie S Satin, Arthur S Sherman
Type 2 diabetes (T2D) is generally thought to result from the combination of 2 metabolic defects, insulin resistance, which increases the level of insulin required to maintain glucose within the normal range, and failure of insulin-secreting pancreatic β-cells to compensate for the increased demand. We build on a mathematical model pioneered by Topp and colleagues to elucidate how compensation succeeds or fails. Their model added a layer of slow negative feedback to the classic insulin-glucose loop in the form of a slow, glucose-dependent birth and death law governing β-cell mass...
February 2016: Endocrinology
https://www.readbyqxmd.com/read/26662378/a-functional-circadian-clock-is-required-for-proper-insulin-secretion-by-human-pancreatic-islet-cells
#17
C Saini, V Petrenko, P Pulimeno, L Giovannoni, T Berney, M Hebrok, C Howald, E T Dermitzakis, C Dibner
AIM: To determine the impact of a functional human islet clock on insulin secretion and gene transcription. METHODS: Efficient circadian clock disruption was achieved in human pancreatic islet cells by small interfering RNA-mediated knockdown of CLOCK. Human islet secretory function was assessed in the presence or absence of a functional circadian clock by stimulated insulin secretion assays, and by continuous around-the-clock monitoring of basal insulin secretion...
April 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/26604652/epidural-anesthesia-improves-pancreatic-perfusion-and-decreases-the-severity-of-acute-pancreatitis
#18
RANDOMIZED CONTROLLED TRIAL
Samira M Sadowski, Axel Andres, Philippe Morel, Eduardo Schiffer, Jean-Louis Frossard, Alexandra Platon, Pierre-Alexandre Poletti, Leo Bühler
AIM: To study the safety of epidural anesthesia (EA), its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis (AP). METHODS: From 2005 to August 2010, patients with predicted severe AP [Ranson score ≥ 2, C-reactive protein > 100 or necrosis on computed tomography (CT)] were prospectively randomized to either a group receiving EA or a control group treated by patient controlled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale (VAS)...
November 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26474424/pancreatitis-global-research-activities-and-gender-imbalances-a-scientometric-approach-using-density-equalizing-mapping
#19
David A Groneberg, Markus Braun, Doris Klingelhoefer, Matthias Bundschuh, Alexander Gerber
OBJECTIVE: Despite the high impact of acute and chronic pancreatitis on the global burden of disease, no scientometric evaluation in this research field has yet been conducted. Therefore, we have issued an analysis in the field of pancreatitis research covering the past 112 years. METHODS: Data were retrieved from the Web of Science database. Density-equalizing mapping and large-scale data analysis were used to visualize bilateral and multilateral research cooperation...
February 2016: Pancreas
https://www.readbyqxmd.com/read/26296750/long-chain-omega-3-fatty-acids-fibrates-and-niacin-as-therapeutic-options-in-the-treatment-of-hypertriglyceridemia-a-review-of-the-literature
#20
REVIEW
Matthew K Ito
Hypertriglyceridemia affects approximately 33% of the US population. Elevated triglyceride levels are independently associated with cardiovascular disease (CVD) risk, and severe hypertriglyceridemia is a risk factor for acute pancreatitis. Guidelines for the management of severe hypertriglyceridemia (≥5.6 mmol/L [≥500 mg/dL]) recommend immediate use of triglyceride-lowering agents; however, statins remain the first line of therapy for the management of mild to moderate hypertriglyceridemia (1.7-5.6 mmol/L [150-499 mg/dL])...
October 2015: Atherosclerosis
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