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TB vitamin D

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https://www.readbyqxmd.com/read/27826955/vitamin-d-supplementation-for-preventing-infections-in-children-under-five-years-of-age
#1
REVIEW
Mohammad Y Yakoob, Rehana A Salam, Farhan R Khan, Zulfiqar A Bhutta
BACKGROUND: Vitamin D is a micronutrient important for bone growth and immune function. Deficiency can lead to rickets and has been linked to various infections, including respiratory infections. The evidence on the effects of supplementation on infections in children has not been assessed systematically. OBJECTIVES: To evaluate the role of vitamin D supplementation in preventing pneumonia, tuberculosis (TB), diarrhoea, and malaria in children under five years of age...
November 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27809789/association-between-tuberculosis-diabetes-and-25-hydroxyvitamin-d-in-tanzania-a-longitudinal-case-control-study
#2
Noémie Boillat-Blanco, Pascal Bovet, Kaushik L Ramaiya, Maliwasa Mganga, Lilian T Minja, Lanja Saleh, Medea Imboden, Christian Schindler, Sebastien Gagneux, Claudia Daubenberger, Klaus Reither, Nicole Probst-Hensch
BACKGROUND: Vitamin D level is inversely associated with tuberculosis (TB) and diabetes (DM). Vitamin D could be a mediator in the association between TB and DM. We examined the associations between vitamin D, TB and DM. METHODS: Consecutive adults with TB and sex- and age-matched volunteers were included in a case-control study in Dar es Salaam, Tanzania. Glycemia and total vitamin D (25(OH)D) were measured at enrolment and after TB treatment in cases. The association between low 25(OH)D (<75 nmol/l) and TB was evaluated by logistic regression adjusted for age, sex, body mass index, socioeconomic status, sunshine hours, HIV and an interaction between low 25(OH)D and hyperglycemia...
November 3, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27785354/the-frequency-distribution-of-vitamin-d-receptor-fok-i-gene-polymorphism-among-ugandan-pulmonary-tb-patients
#3
Ester L Acen, William Worodria, Peter Mulamba, Andrew Kambugu, Joseph Erume
Background:Mycobacterium tuberculosis (TB) is still a major problem globally and especially in Africa. Vitamin D deficiency has been linked to TB in the past and studies have found vitamin D deficiency to be common among Ugandan TB patients. The functional activity of vitamin D is dependent on the genotype of the vitamin D receptor (VDR) polymorphic genes. Recent findings have indicated that VDR polymorphisms may cause increased resistance or susceptibility to TB. The vitamin D ligand and its receptor play a pivotal role in innate immunity by eliciting antimicrobial activity, which is important in prevention of TB...
2016: F1000Research
https://www.readbyqxmd.com/read/27695504/vitamin-d-receptor-gene-foki-polymorphisms-and-tuberculosis-susceptibility-a-meta-analysis
#4
Yan Cao, Xinjing Wang, Zhihong Cao, Xiaoxing Cheng
INTRODUCTION: The association between FokI polymorphism of vitamin D receptor (VDR) and tuberculosis (TB) susceptibility has been investigated previously; however, the results were inconsistent and conflicting. In the present study, a meta-analysis was performed to assess the relationship between VDR FokI gene polymorphism and the risk of TB. MATERIAL AND METHODS: Databases including PubMed and Embase were searched for genetic association studies of FokI polymorphism of vitamin D receptor (VDR) and TB...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27663379/association-between-vitamin-d-supplementation-and-severity-of-tuberculosis-in-wild-boar-and-red-deer
#5
D Risco, F J Salguero, R Cerrato, J Gutierrez-Merino, S Lanham-New, O Barquero-Pérez, J Hermoso de Mendoza, P Fernández-Llario
Tuberculosis (TB) is a chronic disease affecting humans and other mammal species. Severity of TB caused by Mycobacterium tuberculosis in humans seems to be influenced by nutritional factors like vitamin D3 intake. However, this relationship has been scarcely studied in cattle and other mammals infected with Mycobacterium bovis. The aim of this work was to assess if wildlife reservoirs of M. bovis show different levels of TB severity depending on the level of vitamin D found in serum after supplementation with vitamin D3...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27574607/abdominal-tuberculosis-diagnosis-and-demographics-a-10-year-retrospective-review-from-a-single-centre
#6
Jeremy S Nayagam, Claire Mullender, Catherine Cosgrove, Andrew Poullis
AIM: To review all cases of abdominal tuberculosis (ATB) for demographic details, diagnostic work up and evidence of vitamin D deficiency. METHODS: This was a retrospective analysis of all patients diagnosed with ATB from June 2003 to August 2013 at St George's Hospital, London. Demographic data was available from the local tuberculosis database. Further clinical information was collected from electronic patient records, including radiology, endoscopy, microbiology, histology, biochemistry and serology...
August 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27559961/prevalence-and-risk-factors-for-efavirenz-based-antiretroviral-treatment-associated-severe-vitamin-d-deficiency-a-prospective-cohort-study
#7
Hanna Nylén, Abiy Habtewold, Eyasu Makonnen, Getnet Yimer, Leif Bertilsson, Jürgen Burhenne, Ulf Diczfalusy, Eleni Aklillu
Initiation of efavirenz-based combination antiretroviral therapy (cART) is associated with Vitamin D deficiency, but the risk factors including efavirenz pharmacokinetics for cART-induced severe vitamin D deficiency (SVDD) and the impact of anti-tuberculosis (TB) cotreatment are not explored. We investigated the prevalence of SVDD in HIV and TB-HIV coinfected patients and associated risk factors for treatment-induced SVDD.Treatment-naïve Ethiopian HIV patients with (n = 102) or without (n = 89) TB co-infection were enrolled prospectively and received efavirenz-based cART...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27553417/dissecting-host-factors-that-regulate-the-early-stages-of-tuberculosis-infection
#8
Neha Agrawal, Chandrika Bhattacharyya, Ankur Mukherjee, Ubaid Ullah, Bhaswati Pandit, Kanury V S Rao, Partha P Majumder
Incomplete understanding of mechanisms involved in the host-pathogen interactions constrains our efforts to eliminate tuberculosis. In many individuals, resulting from immune response to mycobacterial infection organised structures called granulomas are formed. To identify host responses that may control at least the early stages of infection, we employed an in vitro granuloma model. Here, human PBMCs were infected with live Mycobacterium tuberculosis in culture, and the appearance of granuloma-like structures was monitored over the next several days...
September 2016: Tuberculosis
https://www.readbyqxmd.com/read/27382213/a-cross-sectional-study-of-postpartum-changes-in-bone-status-in-indian-mothers
#9
Neha Kajale, Anuradha Khadilkar, Shashi Chiplonkar, Zulf Mughal, Vaman Khadilkar, Nina Mansukhani
BACKGROUND: Bone turnover is high during lactation. However, studies on bone status of Indian urban mothers are scarce. Hence, the objective was to conduct a cross-sectional study on the lactation-related changes in bone health status of Indian mothers postpartum using Dual X-ray Absorptiometry (DXA) at 3 time points: within a week of delivery, at 1- and 3-years postpartum. We also explored the association of dietary calcium intake, physical activity, serum vitamin D status, and dietary traditional food supplements (Dietary Food supplements) with bone health...
August 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27357175/bone-mineral-density-is-positively-related-to-carotid-intima-media-thickness-findings-from-a-population-based-study-in-adolescents-and-premenopausal-women
#10
Monika Frysz, Kevin Deere, Debbie A Lawlor, Li Benfield, Jon H Tobias, Celia L Gregson
Osteoporosis and cardiovascular disease (CVD) are both common causes of morbidity and mortality. Previous studies, mainly of people older than 60 years, suggest a relationship between these conditions. Our aim was to determine the association between bone characteristics and CVD markers in younger and middle-aged individuals. Women (n = 3366) and their adolescent offspring (n = 4368) from the UK population-based cohort study, Avon Longitudinal Study of Parents and Children (ALSPAC), were investigated...
December 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27160686/vitamin-d-deficiency-associates-with-susceptibility-to-tuberculosis-in-pakistan-but-polymorphisms-in-vdr-dbp-and-cyp2r1-do-not
#11
Kashaf Junaid, Abdul Rehman, David A Jolliffe, Tahir Saeed, Kristie Wood, Adrian R Martineau
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and the vitamin D binding protein (DBP) have been reported to modify the influence of vitamin D deficiency on susceptibility to active tuberculosis (TB) in the UK, but this phenomenon has not been investigated in settings with a high TB burden. SNPs in CYP2R1, which encodes a vitamin D 25-hydroxylase enzyme, are known to influence vitamin D status, but their potential role in determining susceptibility to TB has not previously been investigated in any setting...
May 10, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27156622/elevated-serum-25-hydroxy-oh-vitamin-d-levels-are-associated-with-risk-of-tb-progression-in-gambian-adults
#12
Olumuyiwa Owolabi, Schadrac Agbla, Patrick Owiafe, Simon Donkor, Toyin Togun, Abdou K Sillah, Martin O C Ota, Jayne S Sutherland
BACKGROUND: Vitamin D is essential in the host defence against tuberculosis (TB) as an immune modulator. The aim of this study was to determine the level of 25-hydroxyvitamin D (25 (OH) D) from adult TB index cases before and after treatment and their exposed household contacts (HHC) in The Gambia. METHODS: Serum from adult index TB cases and their TB-exposed household contacts (HHC) was analysed for 25(OH) D and Vitamin D binding protein (VDBP) concentrations. Tuberculin skin test (TST) status was used as a measure of Mycobacterium tuberculosis (Mtb) infectivity in the HHC...
May 2016: Tuberculosis
https://www.readbyqxmd.com/read/27054593/bone-mineral-density-in-young-chilean-patients-with-type-1-diabetes-mellitus
#13
Constanza Mosso, María Isabel Hodgson, Tamara Ortiz, Maria Loreto Reyes
BACKGROUND: In this study, our aim was to analyze bone mineral density (BMD) in patients with type 1 diabetes mellitus (T1DM) and compare them with a healthy reference population; in addition, we aimed to observe the association between BMD and the following variables: age at onset, disease duration, metabolic control, pubertal stage, level of physical activity, clinical parameters and nutrient intake. METHODS: A total of 30 patients with T1DM were included in the study...
June 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27046721/vitamin-d-and-tuberculosis-review-and-association-in-three-rural-provinces-of-afghanistan
#14
P Sarin, J Duffy, Z Mughal, E Hedayat, S Manaseki-Holland
OBJECTIVES: 1) To update the 2006 systematic review and meta-analysis by Nnoaham & Clarke exploring the association between serum vitamin D and risk of active tuberculosis (TB) following discrepant evidence; and 2) to identify whether TB and vitamin D are associated in rural Afghanistan. METHODS: Systematic review and meta-analysis of studies published between January 1980 and June 2014 using Nnoaham & Clarke's methodology. For this case-control study, 90 age- and sex-matched pairs were recruited from rural provinces, and blood 25-hydroxyvitamin D concentrations were measured using enzyme-linked immunosorbent assay...
March 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27009076/vitamin-d-and-airway-infections-a-european-perspective
#15
REVIEW
Armin Zittermann, Stefan Pilz, Harald Hoffmann, Winfried März
Vitamin D has immuno-modulatory properties, and deficient levels of circulating 25-hydroxyvitamin D (<30 nmol/l) may contribute to increased risk of infectious illnesses. This narrative review summarises data on vitamin D status in Europe and updates results of randomised controlled trials (RCTs) regarding vitamin D and airway infections such as tuberculosis (TB) and acute upper respiratory tract infection. In Europe, the prevalence of vitamin D deficiency is up to 37% in the general population and up to 80% in nursing home residents and non-European immigrants...
March 24, 2016: European Journal of Medical Research
https://www.readbyqxmd.com/read/26985430/a-review-of-vitamin-d-effects-on-common-respiratory-diseases-asthma-chronic-obstructive-pulmonary-disease-and-tuberculosis
#16
REVIEW
Mohammad Esmaeil Hejazi, Faezeh Modarresi-Ghazani, Taher Entezari-Maleki
Despite the classic role of Vitamin D in skeletal health, new aspects of Vitamin D have been discovered in tissues and organs other than bones. Epidemiological and observational studies demonstrate a link between Vitamin D deficiency and risk of developing respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and tuberculosis (TB). To review the literature, we searched the terms "Vitamin D" (using the set operator) and "asthma," "COPD" and "TB" in electronic databases, including PubMed/MEDLINE, Scopus, and Google Scholar until July 2015...
January 2016: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/26981576/vitamin-d-d-dimer-interferon-%C3%AE-and-scd14-levels-are-independently-associated-with-immune-reconstitution-inflammatory-syndrome-a-prospective-international-study
#17
Laura W Musselwhite, Bruno B Andrade, Susan S Ellenberg, Ann Tierney, Pablo F Belaunzaran-Zamudio, Adam Rupert, Michael M Lederman, Ian Sanne, Juan G Sierra Madero, Irini Sereti
To determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled in a randomized, placebo-controlled ART initiation trial in South Africa and Mexico to test whether maraviroc could prevent IRIS. Participants were classified prospectively as having IRIS within 6 months of ART initiation. Twenty plasma biomarkers were measured at study enrollment for 267 participants...
February 2016: EBioMedicine
https://www.readbyqxmd.com/read/26976889/vitamin-d-status-in-botswana-children-under-2-years-old-with-and-without-active-tuberculosis
#18
Jonathan Ludmir, Loeto Mazhani, Mark S Cary, Unoda A Chakalisa, John M Pettifor, Mooketsi Molefi, Abiona Redwood, Virginia A Stallings, Robert Gross, Andrew P Steenhoff
Additional strategies are needed to prevent and treat tuberculosis (TB). Although vitamin D may have antimycobacterial effects, it is unknown whether low vitamin D status confers a risk for active TB in African children. This case-control study assessed serum 25-hydroxyvitamin D (25(OH)D) concentration in children with and without active TB in Gaborone, Botswana. A total of 80 children under 2 years old with and without active TB, seen at hospitals and clinics in the greater Gaborone area between September 2010 and November 2012, were enrolled...
May 4, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/26872154/low-vitamin-d-levels-combined-with-pkp3-sigirr-tmem16j-host-variants-is-associated-with-tuberculosis-and-death-in-hiv-infected-and-exposed-infants
#19
Amita Gupta, Grace Montepiedra, Akshay Gupte, Bret Zeldow, Jennifer Jubulis, Barbara Detrick, Avy Violari, Shabir Madhi, Raziya Bobat, Mark Cotton, Charles Mitchell, Stephen Spector
BACKGROUND: This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children. METHODS: A case-cohort sample of 466 South African infants enrolled in P1041 trial (NCT00080119) underwent 25-hydroxyvitamin D testing by chemiluminescent immunoassay. Single nucleotide polymorphisms (SNPs) that alter the effect of vitamin D [e.g. vitamin D receptor (VDR)], vitamin D levels [e...
2016: PloS One
https://www.readbyqxmd.com/read/26869016/vdr-and-vdbp-genes-polymorphisms-associated-with-susceptibility-to-tuberculosis-in-a-han-taiwanese-population
#20
Shih-Wei Lee, Tzu-Yi Chuang, Hsiu-Han Huang, Chi-Wei Liu, Yung-Hsi Kao, Lawrence Shih-Hsin Wu
BACKGROUND: The active metabolite (1, 25-dihydroxycholecalciferol) of vitamin D (25-hydroxycholecalciferol) leads to the activation of macrophages and the deficiency of vitamin D seems to be involved in the risk of tuberculosis (TB). The effects of vitamin D are exerted by interaction with the vitamin D receptor (VDR) and vitamin D receptor binding protein (VDBP) may be influenced by polymorphisms in the VDR and VDBP genes. In this study, variation in the VDR and VDBP genes was investigated in a Taiwanese population with TB...
January 12, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
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