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TB vitamin D

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https://www.readbyqxmd.com/read/28514999/severe-hypovitaminosis-d-in-active-tuberculosis-patients-and-its-predictors
#1
Qiuzhen Wang, Yufeng Liu, Yan Ma, Lei Han, Mei Dou, Yue Zou, Limei Sun, Hong Tian, Tongxia Li, Guofeng Jiang, Baoli Du, Tingyan Kou, Jiaqi Song, Frans J Kok, Evert G Schouten
BACKGROUND & AIMS: Tuberculosis (TB) patients have a significant vitamin D deficiency (VDD) endemic, which may be closely related to the onset and progress of the disease. The comorbidity of diabetes (DM) and TB has posed an increasing challenge in recent years. However, the influence of DM on TB and the possible mechanism are still uncertain. We carried out this study to identify the nutritional status of vitamin D (VD) in TB patients in a northern city in China (latitude 36° N) and investigate the possible predictors of severe vitamin D deficiency (SVDD)...
April 30, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28490367/vitamin-d-deficiency-among-smear-positive-pulmonary-tuberculosis-patients-and-their-tuberculosis-negative-household-contacts-in-northwest-ethiopia-a-case-control-study
#2
Belay Tessema, Feleke Moges, Dereje Habte, Nebiyu Hiruy, Shewaye Yismaw, Kassahun Melkieneh, Yewulsew Kassie, Belaineh Girma, Muluken Melese, Pedro G Suarez
BACKGROUND: Vitamin D is a fat-soluble vitamin that increases the immunity against tuberculosis (TB), decreases the re-activation of latent TB and reduces the severity of active TB disease. Epidemiological studies on the prevalence of vitamin D deficiency, and its association with TB showed inconsistent results in different countries. This study was aimed to determine the prevalence of vitamin D deficiency and its association with TB in Northwest Ethiopia. METHODS: A case-control study was conducted among smear positive pulmonary tuberculosis patients and their household contacts without symptoms suggestive of TB...
May 11, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28482963/paradoxical-upgrading-reaction-in-extra-pulmonary-tuberculosis-association-with-vitamin-d-therapy
#3
D A Barr, A K Coussens, S Irvine, N D Ritchie, K Herbert, B Choo-Kang, D Raeside, D J Bell, R A Seaton
SETTING: Glasgow, Scotland, UK. BACKGROUND: Paradoxical reactions in tuberculosis (TB) are a notable example of our incomplete understanding of host-pathogen interactions during anti-tuberculosis treatment. OBJECTIVES: To determine risk factors for a TB paradoxical reaction, and specifically to assess for an independent association with vitamin D use. DESIGN: Consecutive human immunodeficiency virus (HIV) negative adult patients treated for extra-pulmonary TB were identified from an Extended Surveillance of Mycobacterial Infections database...
June 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28462134/new-4-substituted-benzoyl-%C3%AE-d-glycoside-from-the-fruit-pulp-of-terminalia-belerica-with-antiplatelet-and-antioxidant-potency
#4
Vaseem Ahmad Ansari, Muhammad Arif, Md Sarfaraj Hussain, Hefazat Hussain Siddiqui, Rakesh Kumar Dixit
BACKGROUND: The fruit Terminalia belerica is a rich source of vitamins, acids, and nutraceuticals which have free radical scavenging activity. Thus, the ethanolic extract of fruit and its isolated compound (Tb-01) were intended to estimate antiplatelet and antioxidant activities. METHODS: The ethanolic extract was submitted to Si-gel CC and the compound was isolated. The compound Tb-01 was characterized as benzoyl-β-D-(4'→10″ geranilanoxy)-pyranosides on the basis of spectral data [ultra violet (UV), infrared (IR), (1)H nuclear magnetic resonance (NMR), (13)C NMR, and Mass Spectroscopy] and chemical analyses...
December 2016: Integr Med Res
https://www.readbyqxmd.com/read/28449659/vitamin-d-and-activated-vitamin-d-in-tuberculosis-in-equatorial-malaysia-a-prospective-clinical-study
#5
Anna P Ralph, Muhammad Redzwan S Rashid Ali, Timothy William, Kim Piera, Uma Parameswaran, Elspeth Bird, Christopher S Wilkes, Wai Khew Lee, Tsin Wen Yeo, Nicholas M Anstey
BACKGROUND: Vitamin D deficiency (low plasma 25-hydroxyvitamin D [25D] concentration) is often reported in tuberculosis. Adjunctive vitamin D has been tested for its potential to improve treatment outcomes, but has proven largely ineffective. To better understand vitamin D in tuberculosis, we investigated determinants of 25D and its immunologically active form, 1,25-dihydroxyvitamin D (1,25D), their inter-relationship in tuberculosis, longitudinal changes and association with outcome...
April 27, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28429905/maintenance-vitamin-d3-dosage-requirements-in-chinese-women-with-post-menopausal-osteoporosis-living-in-the-tropics
#6
Yogeswari Venugopal, Sharifah F Wan Muhamad Hatta, Nurbazlin Musa, Siti Abdul Rahman, Jeyakantha Ratnasingam, Sharmila Sunita Paramasivam, Lee Ling Lim, Luqman Ibrahim, Karen Choong, Alexander Tb Tan, Karuthan Chinna, Siew Pheng Chan, Shireene R Vethakkan
BACKGROUND AND OBJECTIVES: Vitamin D3 (cholecalciferol) dose required to maintain sufficiency in non- Caucasian women with postmenopausal osteoporosis (PMO) inthe tropics has not been well studied. Some guidelines mandate 800-1000 IU vitamin D/day but the Endocrine Society (US) advocates 1500-2000 IU/day to maintain 25-hydroxyvitamin-D (25(OH)D) concentration at >75 nmol/L. We aimed to establish oral cholecalciferol dose required to maintain 25(OH)D concentration at >75 nmol/L in PMO Chinese Malaysian women, postulating lower dose requirements amongst light-skinned subjects in the tropics...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28403225/association-of-vitamin-d-deficiency-season-of-the-year-and-latent-tuberculosis-infection-among-household-contacts
#7
María Elvira Balcells, Patricia García, Camila Tiznado, Luis Villarroel, Natalia Scioscia, Camila Carvajal, Francesca Zegna-Ratá, Mariluz Hernández, Paulina Meza, Luis F González, Carlos Peña, Rodrigo Naves
OBJECTIVES: Vitamin D (VD) enhances the immune response against Mycobacterium tuberculosis in vitro, and VD deficiency has been described in patients with active tuberculosis (TB). However, the role of hypovitaminosis D in the pathogenesis of early TB infection acquisition is unclear. We aimed to evaluate the association of VD deficiency, season of the year, and latent TB infection in household contacts (HHC), given that this is a potentially modifiable condition often related to nutritional deficiencies and lack of sun exposure...
2017: PloS One
https://www.readbyqxmd.com/read/28399423/bone-mineral-density-and-vitamin-d-concentration-the-challenges-in-taking-care-of-children-and-adolescents-infected-with-hiv
#8
Fabiana Bononi Carmo, Maria Teresa Terreri, Regina Célia de Menezes Succi, Suenia Vasconcelos Beltrão, Aida de Fátima Tomé Barbosa Gouvea, Erica Regina Cruz Paulino, Daisy Maria Machado
BACKGROUND: The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease. OBJECTIVES: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval. METHODS: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy...
April 8, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28394278/vitamin-d-deficiency-among-adults-with-history-of-pulmonary-tuberculosis-in-korea-based-on-a-nationwide-survey
#9
Mi Hyun Joo, Mi Ah Han, Sun Mi Park, Hwan Ho Shin
We investigated the prevalence of vitamin D deficiency among individuals who have a history of tuberculosis (TB) diagnosis in Korea. Using the 5th Korean National Health and Nutrition Examination Survey, we selected 805 individuals with a history of TB diagnosis and 16,049 controls without a history of TB. Vitamin D deficiency was defined as a 25(OH)D level less than 20 ng/mL. Vitamin D deficiency was revealed in 71.7% of the individuals with a history of TB diagnosis and in 72.1% of the controls. Vitamin D deficiency was more likely in women than in men, in people who engaged in other jobs or were unemployed than in people who engaged in skilled agricultural, forestry, and fishery jobs, and in people who walked 3-5 days per week than in people who walked 6-7 days per week...
April 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28376475/osteopontin-bone-morphogenetic-protein-4-and-vitamin-d-receptor-gene-polymorphisms-in-the-susceptibility-and-clinical-severity-of-spinal-tuberculosis
#10
Guohua Wang, Liangyi Xie, Jianzhong Hu, Hongbin Lu, Xiangyang Liu, Yong Cao, Bin Liu, Yi Zhang, Xiongjie Shen
BACKGROUND/AIMS: Spinal tuberculosis (TB) is a common and dangerous form of extrapulmonary TB with unclear mechanisms in its occurrence and progression. This study investigated the clinical significances of bone morphogenetic protein-4 (BMP-4), osteopontin (OPN), and vitamin D receptor (VDR) gene polymorphism, mRNA and protein expression in spinal TB patients. METHODS: BMP-4 and OPN gene polymorphisms were detected by direct DNA sequencing, while VDR-FokI polymorphisms were analyzed using PCR-RFLP...
April 4, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28367779/regional-solar-radiation-is-inversely-correlated-with-incidence-and-severity-of-tuberculosis-in-chile
#11
M E Balcells, J Cerda, S Concha, R Hoyos-Bachiloglu, C A Camargo, A R Martineau, A Borzutzky
Vitamin D (VD) deficiency has been linked to increased incidence and morbidity of tuberculosis (TB). Chile has large variations in solar radiation (SR; a proxy of VD status) and high prevalence of VD deficiency in its southernmost regions with low SR. We investigated the correlation between regional SR and rates of TB incidence, admissions and deaths in Chile by reviewing national records on prospectively collected mandatory disease notifications, admissions and mortality between 2001 and 2011. Over the study period, 26 691 new TB notifications were registered...
April 3, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28193202/association-of-high-serum-vitamin-d-concentrations-with-active-pulmonary-tb-in-an-hiv-co-endemic-setting-harare-zimbabwe
#12
Cuthbert Musarurwa, Lynn Sodai Zijenah, Doreen Zvipo Duri, Kudzie Mateveke-Dangaiso, Kudakwashe Mhandire, Maria Mary Chipiti, Marshall Wesley Munjoma, Witmore Bayayi Mujaji
BACKGROUND: There is paucity data on the association of vitamin D deficiency (VDD) and active tuberculosis (TB) in southern Africa where the human immunodeficiency virus (HIV) is co-endemic. We examined the association of serum vitamin D concentrations with active pulmonary tuberculosis (PTB) in HIV-infected (n = 284) and uninfected (n = 267) Black Zimbabweans, in Harare, Zimbabwe. METHODS: We conducted a cross-sectional study of 551 participants comprising 145 HIV(+)/PTB (+), 139 HIV(+)/PTB(-), 134 HIV(-)/PTB(+) and 133 HIV(-)/PTB(-)...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28183335/efficacy-of-vitamin-d3-supplementation-in-reducing-incidence-of-pulmonary-tuberculosis-and-mortality-among-hiv-infected-tanzanian-adults-initiating-antiretroviral-therapy-study-protocol-for-a-randomized-controlled-trial
#13
Christopher R Sudfeld, Ferdinand Mugusi, Said Aboud, Tumaini J Nagu, Molin Wang, Wafaie W Fawzi
BACKGROUND: HIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D3 supplementation may improve survival and treatment outcomes for HIV-infected adults initiating ART...
February 10, 2017: Trials
https://www.readbyqxmd.com/read/28169875/vitamin-a-and-d-deficiencies-associated-with-incident-tuberculosis-in-hiv-infected-patients-initiating-antiretroviral-therapy-in-multinational-case-cohort-study
#14
Mark W Tenforde, Ashish Yadav, David W Dowdy, Nikhil Gupte, Rupak Shivakoti, Wei-Teng Yang, Noluthando Mwelase, Cecilia Kanyama, Sandy Pillay, Wadzanai Samaneka, Breno Santos, Selvamuthu Poongulali, Srikanth Tripathy, Cynthia Riviere, Sima Berendes, Javier R Lama, Sandra W Cardoso, Patcharaphan Sugandhavesa, Parul Christian, Richard D Semba, Thomas B Campbell, Amita Gupta
INTRODUCTION: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. METHODS: We conducted a case-cohort study (n=332) within a randomized trial comparing three ART regimens in 1571 HIV treatment-naïve adults from nine countries. A subcohort of 30 patients was randomly selected from each country (n=270)...
February 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28111615/the-effects-of-first-line-anti-tuberculosis-drugs-on-the-actions-of-vitamin-d-in-human-macrophages
#15
Supavit Chesdachai, Susu M Zughaier, Li Hao, Russell R Kempker, Henry M Blumberg, Thomas R Ziegler, Vin Tangpricha
Tuberculosis (TB) is a major global health problem. Patients with TB have a high rate of vitamin D deficiency, both at diagnosis and during the course of treatment with anti-tuberculosis drugs. Although data on the efficacy of vitamin D supplementation on Mycobacterium tuberculosis (Mtb) clearance is uncertain from randomized controlled trials (RCTs), vitamin D enhances the expression of the anti-microbial peptide human cathelicidin (hCAP18) in cultured macrophages in vitro. One possible explanation for the mixed (primarily negative) results of RCTs examining vitamin D treatment in TB infection is that anti-TB drugs given to enrolled subjects may impact actions of vitamin D to enhance cathelicidin in macrophages...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/28096657/vitamin-d-deficiency-and-the-risk-of-tuberculosis-a-meta-analysis
#16
Shao-Jun Huang, Xian-Hua Wang, Zhi-Dong Liu, Wen-Li Cao, Yi Han, Ai-Guo Ma, Shao-Fa Xu
BACKGROUND AND AIM: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB). METHODS: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.3. RESULTS: A significantly lower vitamin D level was found in TB patients vs controls; vitamin D deficiency (VDD) was associated with an increased risk of TB, although such an association was lacking in the African population and in the human immunodeficiency virus-infected African population...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28000582/seasonality-of-tuberculosis-in-israel-2001-2011
#17
I Margalit, C Block, Z Mor
BACKGROUND: Several studies have suggested that the incidence of tuberculosis (TB) varies with the seasons. OBJECTIVE: To determine the seasonality of TB in Israel and to explore possible associations with climatic variables. METHODS: Laboratory-confirmed TB cases reported between 2001 and 2011 in individuals resident in Israel for at least 1 year before diagnosis were included in the study. Climatic variables included average temperature and average ultraviolet radiation...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931332/seasonality-of-tuberculosis-in-israel-20012011
#18
I Margalit, C Block, Z Mor
BACKGROUND: Several studies have suggested that the incidence of tuberculosis (TB) varies with the seasons. OBJECTIVE: To determine the seasonality of TB in Israel and to explore possible associations with climatic variables. METHODS: Laboratory-confirmed TB cases reported between 2001 and 2011 in individuals resident in Israel for at least 1 year before diagnosis were included in the study. Climatic variables included average temperature and average ultraviolet radiation...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27826955/vitamin-d-supplementation-for-preventing-infections-in-children-under-five-years-of-age
#19
REVIEW
Mohammad Y Yakoob, Rehana A Salam, Farhan R Khan, Zulfiqar A Bhutta
BACKGROUND: Vitamin D is a micronutrient important for bone growth and immune function. Deficiency can lead to rickets and has been linked to various infections, including respiratory infections. The evidence on the effects of supplementation on infections in children has not been assessed systematically. OBJECTIVES: To evaluate the role of vitamin D supplementation in preventing pneumonia, tuberculosis (TB), diarrhoea, and malaria in children under five years of age...
November 9, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27809789/association-between-tuberculosis-diabetes-and-25-hydroxyvitamin-d-in-tanzania-a-longitudinal-case-control-study
#20
Noémie Boillat-Blanco, Pascal Bovet, Kaushik L Ramaiya, Maliwasa Mganga, Lilian T Minja, Lanja Saleh, Medea Imboden, Christian Schindler, Sebastien Gagneux, Claudia Daubenberger, Klaus Reither, Nicole Probst-Hensch
BACKGROUND: Vitamin D level is inversely associated with tuberculosis (TB) and diabetes (DM). Vitamin D could be a mediator in the association between TB and DM. We examined the associations between vitamin D, TB and DM. METHODS: Consecutive adults with TB and sex- and age-matched volunteers were included in a case-control study in Dar es Salaam, Tanzania. Glycemia and total vitamin D (25(OH)D) were measured at enrolment and after TB treatment in cases. The association between low 25(OH)D (<75 nmol/l) and TB was evaluated by logistic regression adjusted for age, sex, body mass index, socioeconomic status, sunshine hours, HIV and an interaction between low 25(OH)D and hyperglycemia...
November 3, 2016: BMC Infectious Diseases
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