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TB vitamin D

Ji Wang, Malong Feng, Shidong Ying, Jianfang Zhou, Xiaoqing Li
Background: Vitamin D might be promising to serve as an adjunctive therapy for pulmonary tuberculosis (TB). However, the results remained controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of vitamin D in patients with pulmonary TB. Methods: Medline, SCOPUS, Google Scholar, EMBASE, Springer, and Science Direct were searched electronically from inception to Oct 2016. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) assessing the effect of vitamin D plus anti-tuberculosis treatment (ATT) versus placebo plus ATT on the treatment of pulmonary TB were included...
April 2018: Iranian Journal of Public Health
Christian Wejse
The role of vitamin D in tuberculosis (TB) has been a hot topic for decades, and it is still an unresolved matter. Vitamin D deficiency and other micronutrient deficiencies have been considered as important risk factors for TB and malnutrition is overall a highly important risk factor for TB. In fact with the highest population attributable fraction (PAF) for TB at 27% (1), which means the fraction of all TB cases that would NOT have occurred if exposure (to e.g. malnutrition) was not there. This article is protected by copyright...
June 11, 2018: Journal of Internal Medicine
Evgenia Preka, Bruno Ranchin, Anke Doyon, Melody Vierge, Tiphanie Ginhoux, Behrouz Kassai, Justine Bacchetta
OBJECTIVE: Mineral and bone disorders associated to chronic kidney disease (CKD-MBD) are a daily challenge for pediatric nephrologists, with a significant risk of long-term bone and vascular comorbidities. METHODS: This single-center study is a prospective transversal evaluation of pediatric CKD patients of our center, part of the European 4C study. In addition to clinical and biochemical data, vascular and bone evaluation was performed: 24-h blood pressure assessment, carotid intima-media thickness (cIMT), pulse wave velocity (PWV), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the ultra-distal tibia...
June 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Senait Ashenafi, Jolanta Mazurek, Anders Rehn, Beede Lemma, Getachew Aderaye, Amsalu Bekele, Getachew Assefa, Menberework Chanyalew, Abraham Aseffa, Jan Andersson, Peter Bergman, Susanna Brighenti
Low vitamin D (vitD₃) is one of the most common nutritional deficiencies in the world known to be associated with numerous medical conditions including infections such as tuberculosis (TB). In this study, vitD₃ status and its association with the antimicrobial peptide, human cathelicidin (LL-37), was investigated in Ethiopian patients with different clinical forms of TB. Patients with active TB ( n = 77) and non-TB controls ( n = 78) were enrolled in Ethiopia, while another group of non-TB controls ( n = 62) was from Sweden...
June 4, 2018: Nutrients
Pia Karlsland Åkeson, Kristina Åkesson, Torbjörn Lind, Olle Hernell, Sven-Arne Silfverdal, Inger Öhlund
OBJECTIVES: To evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. METHODS: In a two-center prospective double-blinded randomized intervention study 5-7-year old children (n = 206) with fair and dark skin in Sweden (55°N- 63°N) received daily vitamin D supplements of 25 μg, 10 μg or placebo (2 μg) during three winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN) and spine at baseline and four months later...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
Sanjeev Sinha, Kartik Gupta, Dibyakanti Mandal, B K Das, R M Pandey
Background Vitamin D is an immunomodulator, and its deficiency is associated with tuberculosis (TB) infection. Bronchoalveolar lavage fluid (BALF) is a rich milieu of macrophages that forms the first line of defense against invading TB bacilli. Because there is an increased prevalence of vitamin D deficiency in TB and human-immunodeficiency virus-1 (HIV-1) subjects, we intend exploring the possibility of a localized deficiency of vitamin D metabolites in BALF of these patients. OBJECTIVE: The primary objective was to assess the level of 25D3 in serum and BALF of subjects and look for a significant difference among patients and controls...
May 27, 2018: Current HIV Research
Susanna Brighenti, Peter Bergman, Adrian R Martineau
Tuberculosis (TB) has troubled mankind for millennia, but current treatment strategies are long and complicated and the disease remains a major global health problem. The risk of Mycobacterium tuberculosis (Mtb) infection or progression of active TB disease is elevated in individuals with vitamin D deficiency. High-dose vitamin D was used to treat TB in the pre-antibiotic era, and in vitro experimental data show that vitamin D supports innate immune responses that restrict growth of Mtb. Several randomised controlled trials have tested whether adjunctive vitamin D supplementation enhances the clinical and microbiological response to standard antimicrobial chemotherapy for pulmonary TB...
May 27, 2018: Journal of Internal Medicine
Cuthbert Musarurwa, Lynn Sodai Zijenah, Doreen Zvipo Mhandire, Tsitsi Bandason, Kudakwashe Mhandire, Maria Mary Chipiti, Marshall Wesley Munjoma, Witmore Bayayi Mujaji
BACKGROUND: The inherent risk of developing tuberculosis (TB) in HIV- infected individuals is further enhanced by hypovitaminosis D. Interventions that offset HIV-associated immune deterioration potentially arrest disease progression and incidence of opportunistic infections including TB. Despite conflicting reports on association between vitamin D deficiency (VDD) and risk of TB, vitamin D (VD) supplementation remains a promising intervention. METHODS: We conducted a comparative cross-sectional study on 145 HIV+ /pulmonary TB+ (PTB) and 139 HIV+ /PTB- hospitalised patients to investigate association of vitamin D status and risk of PTB...
May 8, 2018: BMC Pulmonary Medicine
A Bekele, N Gebreselassie, S Ashenafi, E Kassa, G Aseffa, W Amogne, M Getachew, A Aseffa, A Worku, R Raqib, B Agerberth, U Hammar, P Bergman, G Aderaye, J Andersson, S Brighenti
OBJECTIVE: Immunotherapy using vitamin D (vitD3 ) and phenylbutyrate (PBA) may support standard drug regimens used to treat infectious diseases. We investigated if vitD3 + PBA enhanced clinical recovery from pulmonary tuberculosis (TB). METHODS: A randomized controlled trial was conducted in Addis Ababa, Ethiopia. Patients with smear-positive or smear-negative TB received daily oral supplementation with 5000 IU vitD3 and 2 × 500 mg PBA or placebo for 16 weeks, together with 6-month chemotherapy...
April 25, 2018: Journal of Internal Medicine
K Majewski, J Agier, E Kozłowska, E Brzezińska-Błaszczyk
Development of Mycobacterium tuberculosis (Mtb) infection depends on the ability of the host to elicit the protective immune response to the pathogen. Cathelicidin plays a role in antibacterial innate immunity mechanisms. This peptide contributes to the barrier function of respiratory epithelium and takes part in controlling pulmonary bacterial infections. LL-37 (leucine-leucine-37) is involved in host defense and innate immune response to mycobacterial infections, as well. This study aims to evaluate the serum concentrations of LL-37 in individuals with active pulmonary tuberculosis (TB) and to determine whether any correlations between peptide LL-37, tumor necrosis factor (TNF) and vitamin D serum levels exist...
March 2018: Journal of Biological Regulators and Homeostatic Agents
Greta Musteikienė, Skaidrius Miliauskas, Jurgita Zaveckienė, Marius Žemaitis, Astra Vitkauskienė
OBJECTIVE: The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment. MATERIALS AND METHODS: A total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), they were asked about smoking, alcohol use, living conditions and education. Body mass index (BMI) measurements, laboratory tests (C reactive protein [CRP], vitamin D, albumin) were performed, and chest X-ray was done...
2017: Medicina
Liina Mansukoski, Vitale Stefano Sparacello
There is little research on how individuals suffering from tuberculosis may differ from those not infected in terms of overall skeletal morphology. Tuberculosis was endemic in 19th and early 20th century Finland making documented skeletal collections of Finns ideal to study effects of the disease on bone. The present study compares long bone cross-sectional total area between individuals who died of tuberculosis and those with another recorded cause of death in a Finnish sample. Adult male individuals (N = 105) were selected for analysis...
March 2018: International Journal of Paleopathology
Omowunmi Aibana, Molly F Franke, Chuan-Chin Huang, Jerome T Galea, Roger Calderon, Zibiao Zhang, Mercedes C Becerra, Emily R Smith, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B Murray
Background: Few studies have previously assessed how pre-existing vitamin E status is associated with risk of tuberculosis (TB) disease progression. Objective: We evaluated the association between baseline plasma concentrations of 3 vitamin E isomers (α-tocopherol, γ-tocopherol, and δ-tocopherol) and TB disease risk. Methods: We conducted a case-control study nested within a longitudinal cohort of household contacts (HHCs) of pulmonary TB cases in Lima, Peru...
January 1, 2018: Journal of Nutrition
Elisangela B Maceda, Crhistinne C M Gonçalves, Jason R Andrews, Albert I Ko, Catherine W Yeckel, Julio Croda
Poor vitamin D status has been associated with tuberculosis (TB); whether poor status is cause or consequence of disease is uncertain. We conducted a case-control study and two nested case-control studies to determine whether vitamin D levels were associated with active TB, tuberculin skin test (TST) conversion, and risk of progression to the active TB in prisoners in Brazil. In multivariable conditional logistic regression, subnormal vitamin D levels (OR, 3.77; 95% CI, 1.04-13.64) were more likely in prisoners with active TB...
January 17, 2018: Scientific Reports
Swati Gautam, Amita Jain, Salman Akhtar, Apala Priyadarshini, Shyam Pyari Jaiswar
Introduction: Vitamin D is now known to be essential to Mycobacterium tuberculosis containment and killing through activation of 25-hydroxyvitamin-D receptors (VDRs) present on all immune cells or obtained from dietary food stuffs as either vitamin D3 or vegetable vitamin D2 (also known as ergocalciferol). Aim: To evaluate the association of serum vitamin D level between the Female Genital Tuberculosis (FGTB) cases and healthy controls. Materials and Methods: Total 120 cases and 120 controls enrolled for the study following inclusion and exclusion criteria...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Catherine King, Lorraine Harper
Purpose of review With established immunosuppressant treatment regimens for anti-neutrophil cytoplasm antibody-associated vasculitides (AAV), prognosis has significantly improved. The mainstay of treatment still comprises high-dose corticosteroids and cyclophosphamide for severe forms, although rituximab is being increasingly utilised instead of cyclophosphamide as induction therapy. AAV patients experience an excess of infections, malignancies and cardiovascular events as compared to the general population, which is a combination of the systemic inflammatory process associated with vasculitis and the adverse events from treatment...
2017: Current Treatment Options in Rheumatology
Manik Retno Wahyunitisari, Ni Made Mertaniasih, Muhammad Amin, Wayan T Artama, Eko B Koendhori
BACKGROUND: Mycobacterium tuberculosis induces cellular necrosis that could promote spread of infection. The aim of this study is to analyze the effects of Vitamin D3 supplementation to improve the effectiveness of 2nd-line anti-tuberculosis (TB) drug therapy, especially in relation with cell death pathways. METHODS: Mus musculus C3HeB/FeJ was randomly divided into four groups containing eight animals each. The 1st group (G1), consisting of mice that were intratracheally infected with multidrug-resistant strain of M...
October 2017: International Journal of Mycobacteriology
Gaurav Tyagi, Pooja Singh, Mandira Varma-Basil, Mridula Bose
Worldwide, tuberculosis (TB) is still a serious and significant health concern, more so with the emergence of multidrug-resistant-TB. The inability of mankind to control this infection stems from the fact that the vaccines and drugs that were once effective against TB are no longer efficacious. This has led to a search for new antituberculous agents and adjuvant therapy. Vitamins are being revisited for their role in pathogenicity as well as for their antimycobacterial properties. Vitamins such as biotin and thiamin are essential for Mycobacterium tuberculosis and are required for establishment of infection...
October 2017: International Journal of Mycobacteriology
G L Lima, J A Paupitz, N E Aikawa, J C Alvarenga, R M Rodrigues Pereira
In this randomized double-blind placebo-controlled 24-week trial, cholecalciferol supplementation at 50,000 IU/week effectively improved bone microarchitecture parameters in juvenile-onset systemic lupus erythematosus (JoSLE) patients, as assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at tibia site. An increase in the trabecular number and a decrease in the trabecular separation were observed, suggesting that vitamin D supplementation may be recommended for JoSLE patients with its deficiency...
March 2018: Osteoporosis International
Afsal Kolloli, Selvakumar Subbian
Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), remains a leading cause of morbidity and mortality in humans worldwide. Currently, the standard treatment for TB involves multiple antibiotics administered for at least 6 months. Although multiple antibiotics therapy is necessary to prevent the development of drug resistance, the prolonged duration of treatment, combined with toxicity of drugs, contributes to patient non-compliance that can leads to the development of drug-resistant Mtb (MDR and XDR) strains...
2017: Frontiers in Medicine
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