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https://www.readbyqxmd.com/read/28935040/cardiopulmonary-exercise-testing-what-is-its-value
#1
REVIEW
Marco Guazzi, Francesco Bandera, Cemal Ozemek, David Systrom, Ross Arena
Compared with traditional exercise tests, cardiopulmonary exercise testing (CPET) provides a thorough assessment of exercise integrative physiology involving the pulmonary, cardiovascular, muscular, and cellular oxidative systems. Due to the prognostic ability of key variables, CPET applications in cardiology have grown impressively to include all forms of exercise intolerance, with a predominant focus on heart failure with reduced or with preserved ejection fraction. As impaired cardiac output and peripheral oxygen diffusion are the main determinants of the abnormal functional response in cardiac patients, invasive CPET has gained new popularity, especially for diagnosing early heart failure with preserved ejection fraction and exercise-induced pulmonary hypertension...
September 26, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28915538/long-term-t3-and-t4-treatment-as-an-alternative-to-aerobic-exercise-training-in-improving-cardiac-function-post-myocardial-infarction
#2
Rayane Brinck Teixeira, Alexsandra Zimmer, Alexandre Luz de Castro, Bruna Gazzi de Lima-Seolin, Patrick Türck, Rafaela Siqueira, Adriane Belló-Klein, Pawan K Singal, Alex Sander da Rosa Araujo
Here we aimed to compare the beneficial effects of T3 and T4 hormone treatment to those provided by aerobic exercise training in Wistar rats post-myocardial infarction (MI). Rats in one group were SHAM-operated and in the other group were subjected to MI surgery. One week after surgery, the MI group animals either received T3 and T4 hormones by gavage or underwent a low intensity aerobic exercise training protocol on a treadmill, and both treatments lasted until 10 weeks after MI. Untreated SHAM-operated and MI groups were also followed for the same duration...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28906019/response-letter-to-optimising-physiology-for-adolescents-with-dysautonomia
#3
K Armstrong, A M De Souza, P Sneddon, J E Potts, V E Claydon, S Sanatani
We would like to thank Dr Thaxter Nesbeth (1) for her interest and insightful comments on our paper entitled, "Exercise and the multidisciplinary holistic approach to adolescent dysautonomia"(2). We agree that recurrent orthostatic intolerance is often best managed through lifestyle modification rather than pharmacologic intervention (at least as an initial step), and as such in the present study we evaluated the impact of our exercise programme incorporated in addition to our standard clinical multidisciplinary management approach...
September 14, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28895507/functional-impact-of-exercise-pulmonary-hypertension-in-patients-with-borderline-resting-pulmonary-arterial-pressure
#4
Rudolf K F Oliveira, Mariana Faria-Urbina, Bradley A Maron, Mario Santos, Aaron B Waxman, David M Systrom
Borderline resting mean pulmonary arterial pressure (mPAP) is associated with adverse outcomes and affects the exercise pulmonary vascular response. However, the pathophysiological mechanisms underlying exertional intolerance in borderline mPAP remain incompletely characterized. In the current study, we sought to evaluate the prevalence and functional impact of exercise pulmonary hypertension (ePH) across a spectrum of resting mPAP's in consecutive patients with contemporary resting right heart catheterization (RHC) and invasive cardiopulmonary exercise testing...
July 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28887041/partial-anomalous-pulmonary-venous-connection-in-a-dog
#5
Chloe L Thorn, Naomi R Ford, Meg M Sleeper
A 2-year-old male intact Belgian Malinois was presented for exercise intolerance. A grade III/VI left basilar systolic murmur was detected. Echocardiography revealed moderate right atrial and ventricular dilation and increased pulmonic outflow velocity. Thoracic radiographs showed right heart enlargement and a dilated caudal vena cava. In addition, on the left lateral projection, an enlarged aberrant right cranial pulmonary lobar vein was suspected to be diverging ventrally from the course of the right cranial lobar bronchus and inserting more ventrally than normal in the region of the right atrium...
September 5, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28884075/laryngeal-paralysis-associated-with-a-muscle-pseudotumour-in-a-young-dog
#6
Francesca Rizzo, Cecilia Benetti, Consuelo Ballatori, Diana Binanti
An 18-month-old male entire Bloodhound dog was presented with a six-week history of progressive inspiratory dyspnoea, stridor, dysphonia and exercise intolerance. CT scan performed elsewhere had revealed the presence of an unencapsulated nodular mass (3x1x5 cm) dorsal to the larynx and first tracheal rings. Laryngoscopy demonstrated the presence of bilateral laryngeal paralysis and distorted laryngeal architecture suggestive of extraluminal compression. Histopathology results of incisional biopsies from the mass were suggestive of a benign non-neoplastic muscular lesion...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28879684/epigenetic-regulation-of-sirt1-induced-skeletal-muscle-mass-exercise-and-heart-diseases
#7
Tiago Fernandes, João Lucas P Gomes, André C Silveira
Skeletal myopathy is commonly recognized as a major cause of exercise intolerance in cardiac diseases such as chronic heart failure; which contributes to increased morbidity and mortality. This article is protected by copyright. All rights reserved.
September 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28878952/pathophysiology-of-exercise-intolerance-in-chronic-diseases-the-role-of-diminished-cardiac-performance-in-mitochondrial-and-heart-failure-patients
#8
Jodi McCoy, Matthew Bates, Christopher Eggett, Mario Siervo, Sophie Cassidy, Jane Newman, Sarah A Moore, Grainne Gorman, Michael I Trenell, Lazar Velicki, Petar M Seferovic, John G F Cleland, Guy A MacGowan, Doug M Turnbull, Djordje G Jakovljevic
OBJECTIVE: Exercise intolerance is a clinical hallmark of chronic conditions. The present study determined pathophysiological mechanisms of exercise intolerance in cardiovascular, neuromuscular, and metabolic disorders. METHODS: In a prospective cross-sectional observational study 152 patients (heart failure reduced ejection fraction, n=32; stroke, n=34; mitochondrial disease, n=28; type two diabetes, n=28; and healthy controls, n=30) performed cardiopulmonary exercise testing with metabolic and haemodynamic measurements...
2017: Open Heart
https://www.readbyqxmd.com/read/28870770/mechanisms-of-the-improvement-in-peak-vo2-with-exercise-training-in-heart-failure-with-reduced-or-preserved-ejection-fraction
#9
REVIEW
Wesley J Tucker, Cecilia C Lijauco, Christopher M Hearon, Siddhartha S Angadi, Michael D Nelson, Satyam Sarma, Shane Nanayakkara, André La Gerche, Mark J Haykowsky
Heart failure (HF) is a major health care burden associated with high morbidity and mortality. Approximately 50% of HF patients have reduced ejection fraction (HFrEF) while the remainder of patients have preserved ejection fraction (HFpEF). A hallmark of both HF phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary to impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training is a safe and effective intervention to improve peak oxygen uptake (VO2peak) and quality of life in clinically stable HF patients, however, evidence to date suggests that the mechanism of this improvement appears to be related to underlying HF phenotype...
August 4, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28868593/mutation-in-the-agk-gene-in-two-siblings-with-unusual-sengers-syndrome
#10
Sanae Allali, Imen Dorboz, Simon Samaan, Abdelhamid Slama, Charlène Rambaud, Odile Boespflug-Tanguy, Catherine Sarret
Sengers syndrome is a rare autosomal recessive metabolic disorder caused by lack of acylglycerol kinase due to mutations in the AGK gene. It is characterized by congenital cataract, hypertrophic cardiomyopathy, myopathy and lactic acidosis. Two clinical forms have been described: a severe neonatal form, and a more benign form displaying exercise intolerance. We describe two siblings with congenital cataract, cardiomyopathy, hypotonia, intellectual disability and lactic acidosis. Whole exome sequencing revealed a homozygous c...
September 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28862962/inspiratory-muscle-training-is-associated-with-improved-inspiratory-muscle-strength-resting-cardiac-output-and-the-ventilatory-efficiency-of-exercise-in-patients-with-a-fontan-circulation
#11
Karina Laohachai, David Winlaw, Hiran Selvadurai, Ganesh Kumar Gnanappa, Yves d'Udekem, David Celermajer, Julian Ayer
BACKGROUND: Patients with a Fontan circulation have reduced exercise capacity and respiratory muscle strength. Inspiratory muscle training (IMT) improves exercise capacity and quality of life in adults with heart failure. We assessed whether 6 weeks of a home-based program of IMT improves inspiratory muscle strength and the ventilatory efficiency of exercise in adolescent patients with a Fontan circulation. METHODS AND RESULTS: Twenty-three adolescent participants (aged 16±2 years) with a Fontan circulation underwent 6 weeks of IMT for 30 minutes daily...
August 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28862244/isolated-left-sided-pulmonary-artery-agenesis-with-left-lung-hypoplasia-a-report-of-two-cases
#12
V Govindaraj, J Joseph, B Nagamalli Kumar, R Soman
Unilateral absence of pulmonary artery or pulmonary artery agenesis (UAPA) is a rare congenital malformation that can present as an isolated lesion or in association with other cardiac anomalies. Though congenital, presentation in adults are also reported. Most common presentation in adults is of exercise intolerance. The developing lung on the affected side is hypoplastic. Diagnosis of UAPA is established by imaging methods like CT and MRI . There is no specific treatment for this condition. Treatment depends on patients symptomatology, presence of pulmonary hypertension and collateral circulation...
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28858014/the-effects-of-obesity-on-pulmonary-function-in-children
#13
Courtney Durbin, Robin Egan, Kristin Gervasi, Nicole Nadeau, Emily Neal, Suzanne Reich, Tanya Gregory
The prevalence of obesity has risen rapidly in the United States in the past 20 years. Up to 25% of US children are obese, and obesity can be directly correlated with immediate and long-term health consequences. Pediatric obesity can harm multiple body systems and is a public health issue. This article focuses on how obesity affects a child's respiratory system, including pulmonary function, exercise intolerance, gas exchange, and airway musculature.
September 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28857453/prior-endurance-training-enhances-beta-adrenergic-signaling-in-epidydimal-adipose-from-mice-fed-a-high-fat-diet
#14
Laelie A Snook, Sarah K Trottier, Elizabeth A Worndl, Eric Bombardier, A Russell Tupling, Rebecca E K MacPherson
OBJECTIVE: Adipose tissue beta-adrenergic signaling is attenuated in obesity and insulin resistance. It has been previously demonstrated that prior exercise training protects against short-term, high-fat diet (HFD)-induced weight gain and glucose intolerance. This study aimed to determine whether prior exercise training results in altered beta-adrenergic and lipolytic signaling in adipose tissue when challenged with a HFD. METHODS: Male C57BL/6J mice underwent 4 weeks of treadmill training (1 h/d, 5 d/wk)...
August 31, 2017: Obesity
https://www.readbyqxmd.com/read/28845582/pathophysiology-of-exercise-intolerance-in-pulmonary-arterial-hypertension
#15
REVIEW
Derek L Tran, Edmund M T Lau, David S Celermajer, Glen M Davis, Rachael Cordina
Pulmonary arterial hypertension (PAH) is a chronic disease with poor prognosis and important exercise limitation despite the proliferation of treatment options in the last decade. Chronically increased right ventricular (RV) afterload results in right heart failure and without treatment, rapid clinical deterioration is common. Exercise intolerance is the cardinal feature of the disease impacting upon quality of life and clinical outcome. The pathophysiological mechanisms that lead to reduced exercise capacity in this population are complex with ventriculoarterial uncoupling likely to be the predominant feature...
August 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28843325/pulmonary-valve-procedures-late-after-repair-of-tetralogy-of-fallot-current-perspectives-and-contemporary-approaches-to-management
#16
REVIEW
Catriona J Bhagra, Edward J Hickey, Alexander Van De Bruaene, S Lucy Roche, Eric M Horlick, Rachel M Wald
Few topics in adult congenital heart disease have approached the level of scrutiny bestowed on pulmonary valve replacement (PVR) strategies late after tetralogy of Fallot (TOF) repair. Despite the successes of primary surgery for TOF, there is a growing group of adults with residual right ventricular outflow tract and pulmonary valve dysfunction. Patients with residual chronic pulmonic regurgitation as a consequence of earlier surgery can later develop symptoms of exercise intolerance and complications including heart failure, tachyarrhythmias, and sudden cardiac death...
September 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28841877/influence-of-resting-lung-diffusion-on-exercise-capacity-in-patients-with-copd
#17
Mehrdad Behnia, Courtney Wheatley, Alberto Avolio, Bruce Johnson
BACKGROUND: Lung diffusing capacity for carbon monoxide (DLCO) gives an overall assessment of functional lung surface area for gas exchange and can be assessed using various methods. DLCO is an important factor in exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). We investigated if the intra-breath (IBDLCO) method may give a more sensitive measure of available gas exchange surface area than the more typical single breath (SBDLCO) method and if COPD subjects with the largest resting DLCO relative to pulmonary blood flow (Qc) would have a more preserved exercise capacity...
August 25, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28841254/functional-capacity-in-a-rat-model-of-heart-failure-impact-of-myocardial-infarction-size
#18
Vítor Scotta Hentschke, Lucas Capalonga, Douglas Dalcin Rossato, Júlia Luíza Perini, Jadson Pereira Alves, Edson Quagliotto, Giuseppe Potrick Stefani, Marlus Karsten, Mauro Pontes, Pedro Dal Lago
Oxygen uptake (VO2 ) and exercise tolerance in rats classified by myocardial infarction (MI) size are underexplored. The aim of this study was to evaluate VO2 /carbon dioxide production (VCO2 ) and exercise tolerance in rats that have undergone MI. Fourteen weeks after MI or sham surgery, rats underwent an integrated approach to left ventricular function and VO2 /VCO2 , exercise tolerance and skeletal muscle weight evaluation. Based on MI size determination, rats were assigned to sham operated controls (Sham, n = 12), small myocardial infarction (SMI, n = 8), and large myocardial infarction (LMI, n = 5) groups...
August 25, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28839007/curcumin-limits-weight-gain-adipose-tissue-growth-and-glucose-intolerance-following-the-cessation-of-exercise-and-caloric-restriction-in-rats
#19
Trevor Teich, Jacklyn A Pivovarov, Deanna P Porras, Emily C Dunford, Michael C Riddell
Weight regain, adipose tissue growth, and insulin resistance can occur within days after the cessation of regular dieting and exercise. We investigated the effect of curcumin on preserving metabolic health and limiting adipose tissue growth following the cessation of daily exercise and caloric restriction (CR). Sprague-Dawley rats (6-7 wks old) underwent a 'training' protocol of 24 hr voluntary running wheel access and CR (15-20 g/day) for 3 wks ('All Trained') or were sedentary and fed ad libitum ('Sed'). After 3 wks, 'All Trained' were randomly divided into one group which was terminated immediately ('Trained'), and two detrained groups which had their wheels locked and were reintroduced to ad libitum feeding for 1 wk...
August 24, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28836730/iron-deficiency-in-heart-failure-efficacy-and-safety-of-intravenous-iron-therapy
#20
Chan-Keat Kang, Michael Pope, Chim C Lang, Paul R Kalra
AIM: To discuss the pathophysiology of iron metabolism in chronic heart failure (CHF), the current knowledge of the efficacy of intravenous (IV) iron therapy in patients with CHF and identify points of controversy as well as highlight areas for future research. DISCUSSION: Iron deficiency is a recognised complication of many chronic conditions. Numerous studies have reported that iron deficiency is highly prevalent in patients with CHF and is associated with exercise intolerance, reduced quality of life, and increased risk of hospitalisation and mortality...
August 24, 2017: Cardiovascular Therapeutics
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