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https://www.readbyqxmd.com/read/29319788/relationship-of-loop-diuretic-use-with-exercise-intolerance-in-heart-failure-with-preserved-ejection-fraction
#1
David Montero, Thomas Haider
No abstract text is available yet for this article.
January 8, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29300979/high-intensity-exercise-decreases-ip6k1-muscle-content-improves-insulin-sensitivity-si2-in-glucose-intolerant-individuals
#2
Jane Naufahu, Bradley Elliott, Anatoliy Markiv, Petra Dunning-Foreman, Maggie McGrady, David Howard, Peter Watt, Richard W A Mackenzie
Context: Insulin resistance in skeletal muscle contributes to whole body hyperglycaemia and the secondary complications associated with type 2 diabetes. Inositol hexakisphosphate kinase-1 (IP6K1) may inhibit insulin-stimulated glucose transport in this tissue type. Objective: Muscle and plasma IP6K1 were correlated with two-compartment models of glucose control in insulin-resistant hyperinsulimic individuals. Muscle IP6K1 was also compared following two different exercise trials...
December 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29289723/diaphragm-muscle-dysfunction-in-patients-with-heart-failure
#3
Mari Miyagi, Yoshiharu Kinugasa, Takeshi Sota, Kensaku Yamada, Takuya Ishisugi, Masayuki Hirai, Kiyotaka Yanagihara, Nobuhiko Haruki, Koichi Matsubara, Masahiko Kato, Kazuhiro Yamamoto
BACKGROUND: Inspiratory muscle weakness is associated with the development of exercise intolerance in patients with heart failure (HF). Ultrasound assessment of the diaphragm is used to evaluate respiratory muscle function, but its application in patients with HF remains undefined. We examined the relationship of diaphragm function as assessed by ultrasonography with inspiratory muscle strength and exercise tolerance in HF. METHODS AND RESULTS: Seventy-seven patients hospitalized with HF were enrolled...
December 28, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29289553/advanced-aging-causes-diaphragm-functional-abnormalities-global-proteome-remodeling-and-loss-of-mitochondrial-cysteine-redox-flexibility-in-mice
#4
Rachel C Kelley, Brian McDonagh, Leonardo F Ferreira
AIM: Inspiratory muscle (diaphragm) function declines with age, contributing to exercise intolerance and impaired airway clearance. Studies of diaphragm dysfunction in rodents have focused on moderate aging (~24months); thus, the impact of advanced age on the diaphragm and potential mechanisms of dysfunction are less clear. Therefore, we aimed to define the effects of advanced age on the mechanics, morphology, and global and redox proteome of the diaphragm. METHODS: We studied diaphragm from young (6months) and very old male mice (30months)...
December 28, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29260009/adult-onset-of-mitochondrial-myopathy-encephalopathy-lactic-acidosis-and-stroke-like-episodes-melas-syndrome-with-hypothyroidism-and-psychiatric-disorders
#5
Yu-Xing Ge, Bo Shang, Wen-Zhen Chen, You Lu, Jue Wang
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a clinical syndrome associated with mitochondrial disorders (MIDs). This report illustrates a case of MELAS syndrome with hypothyroidism and psychiatric disorders, which is different from the common clinical manifestations of MELAS syndrome, such as exercise intolerance, migraine-like headaches, hearing loss and seizures etc. There are considerable interests in the possibility that mitochondrial dysfunction may play a role in the pathogenesis of endocrine dysfunctions and psychiatric disorders in MELAS syndrome...
March 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29251685/a-new-condition-in-mcardle-disease-poor-bone-health-benefits-of-an-active-lifestyle
#6
Irene Rodríguez-Gómez, Alfredo Santalla, Jorge Díez-Bermejo, Diego Munguía-Izquierdo, Luis M Alegre, Gisela Nogales-Gadea, Joaquin Arenas, Miguel Ángel Martín, Alejandro Lucía, Ignacio Ara
INTRODUCTION-PURPOSE: McArdle disease (muscle glycogen phosphorylase deficiency) is a genetic condition associated with exercise intolerance, but how it affects lean mass (LM) and bone mineral content (BMC) and density (BMD) in patients is unknown. We compared these variables between McArdle patients and age-/sex-matched healthy controls and assessed their potential association with physical activity levels in patients. METHODS: A case-control, cross-sectional design was used to examine LM, BMC, and BMD by using dual-energy x-ray absorptiometry in 136 young adults of both sexes (36 McArdle patients (33 ± 15 yr) and 103 controls (34 ± 11 yr))...
January 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29248640/association-of-active-and-passive-components-of-lv-diastolic-filling-with-exercise-intolerance-in-heart-failure-with-preserved-ejection-fraction-mechanistic-insights-from-spironolactone-response
#7
Wojciech Kosmala, Monika Przewlocka-Kosmala, Thomas H Marwick
OBJECTIVES: This study sought to investigate the association of left ventricular (LV) untwisting rate (UT) and E/e' ratio with the response of exercise capacity to spironolactone in heart failure with preserved ejection fraction (HFpEF). BACKGROUND: In most patients with HFpEF, LV filling abnormalities represent a central component in the development of dyspnea. LV diastolic filling is determined by the interplay of passive (LV stiffness and myocardial collagen content, reflected by E/e' ratio) and active myocardial properties (UT, a precursor to isovolumic pressure decay and contributor to diastolic suction)...
December 8, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29229098/pulmonary-veno-occlusive-disease-an-important-consideration-in-patients-with-pulmonary-hypertension
#8
REVIEW
Ryan Balko, Hawa Edriss, Kenneth Nugent, Victor Test
Pulmonary veno-occlusive disease is a rare subcategory of pulmonary arterial hypertension (WHO Group 1). The disease is poorly understood and difficult to diagnose; it has no definitive cure to date. These patients present with nonspecific symptoms, including dyspnea, exercise intolerance, and weakness. Chest x-rays sometimes differ from idiopathic pulmonary arterial hypertension and may demonstrate alveolar infiltrates and pleural effusions. High resolution computed tomography scans reveal ground glass opacities, interlobular septal thickening, and lymphadenopathy...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29223996/metabolic-myopathies-a-practical-approach
#9
REVIEW
James B Lilleker, Yann Shern Keh, Federico Roncaroli, Reena Sharma, Mark Roberts
Metabolic myopathies are a diverse group of rare genetic disorders and their associated muscle symptoms may be subtle. Patients may present with indolent myopathic features, exercise intolerance or recurrent rhabdomyolysis. Diagnostic delays are common and clinicians need a high index of suspicion to recognise and differentiate metabolic myopathies from other conditions that present in a similar fashion. Standard laboratory tests may be normal or non-specific, particularly between symptomatic episodes. Targeted enzyme activity measurement and next-generation genetic sequencing are increasingly used...
December 9, 2017: Practical Neurology
https://www.readbyqxmd.com/read/29222399/pediatric-disorders-of-orthostatic-intolerance
#10
REVIEW
Julian M Stewart, Jeffrey R Boris, Gisela Chelimsky, Phillip R Fischer, John E Fortunato, Blair P Grubb, Geoffrey L Heyer, Imad T Jarjour, Marvin S Medow, Mohammed T Numan, Paolo T Pianosi, Wolfgang Singer, Sally Tarbell, Thomas C Chelimsky
Orthostatic intolerance (OI), having difficulty tolerating an upright posture because of symptoms or signs that abate when returned to supine, is common in pediatrics. For example, ∼40% of people faint during their lives, half of whom faint during adolescence, and the peak age for first faint is 15 years. Because of this, we describe the most common forms of OI in pediatrics and distinguish between chronic and acute OI. These common forms of OI include initial orthostatic hypotension (which is a frequently seen benign condition in youngsters), true orthostatic hypotension (both neurogenic and nonneurogenic), vasovagal syncope, and postural tachycardia syndrome...
January 2018: Pediatrics
https://www.readbyqxmd.com/read/29210875/comparison-of-the-effects-of-benson-muscle-relaxation-and-nature-sounds-on-the-fatigue-in-patients-with-heart-failure-a-randomized-controlled-clinical-trial
#11
Leila Seifi, Tahereh Najafi Ghezeljeh, Hamid Haghani
This study was conducted with the aim of comparing the effects of Benson muscle relaxation and nature sounds on fatigue in patients with heart failure. Fatigue and exercise intolerance as prevalent symptoms experienced by patients with heart failure can cause the loss of independence in the activities of daily living. It can also damage self-care and increase dependence to others, which subsequently can reduce the quality of life. This randomized controlled clinical trial was conducted in an urban area of Iran in 2016...
January 2018: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29203714/exercise-heat-shock-proteins-and-insulin-resistance
#12
REVIEW
Ashley E Archer, Alex T Von Schulze, Paige C Geiger
Best known as chaperones, heat shock proteins (HSPs) also have roles in cell signalling and regulation of metabolism. Rodent studies demonstrate that heat treatment, transgenic overexpression and pharmacological induction of HSP72 prevent high-fat diet-induced glucose intolerance and skeletal muscle insulin resistance. Overexpression of skeletal muscle HSP72 in mice has been shown to increase endurance running capacity nearly twofold and increase mitochondrial content by 50%. A positive correlation between HSP72 mRNA expression and mitochondrial enzyme activity has been observed in human skeletal muscle, and HSP72 expression is markedly decreased in skeletal muscle of insulin resistant and type 2 diabetic patients...
January 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29202762/myocyte-membrane-and-microdomain-modifications-in-diabetes-determinants-of-ischemic-tolerance-and-cardioprotection
#13
REVIEW
Jake Russell, Eugene F Du Toit, Jason N Peart, Hemal H Patel, John P Headrick
Cardiovascular disease, predominantly ischemic heart disease (IHD), is the leading cause of death in diabetes mellitus (DM). In addition to eliciting cardiomyopathy, DM induces a 'wicked triumvirate': (i) increasing the risk and incidence of IHD and myocardial ischemia; (ii) decreasing myocardial tolerance to ischemia-reperfusion (I-R) injury; and (iii) inhibiting or eliminating responses to cardioprotective stimuli. Changes in ischemic tolerance and cardioprotective signaling may contribute to substantially higher mortality and morbidity following ischemic insult in DM patients...
December 4, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29199262/impaired-bioenergetics-in-clinical-medicine-a-target-to-tackle
#14
Sergej M Ostojic
Mitochondrial energy deficit is considered a key element of different clinical pathologies - from inherited disorders of energy metabolism to drug-induced mitochondrial toxicity, to cardiometabolic and neurodegenerative diseases. However, clinical manifestations of impaired bioenergetics are not easy to recognize, with patient-reported features usually include non-pathognomonic fatigue and weakness, or exercise intolerance, while specific lab tests are missing. Although it is not clear whether poor energetics is a primary deficit or a secondary consequence of specific disorders, improving mitochondrial viability remains a challenging task in both experimental and clinical medicine...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29198450/effects-of-exercise-on-non-motor-symptoms-in-parkinson-s-disease
#15
Amy W Amara, Adeel A Memon
Patients with Parkinson's disease experience disabling non-motor symptoms, including autonomic dysfunction, cognitive decline, and sleep disorders. Pharmacologic treatments for these symptoms are often ineffective or have intolerable side effects. Therefore, non-pharmacologic interventions are an attractive alternative. Exercise in particular has the potential to alleviate the progressive impairment related to these non-motor symptoms. In this commentary, we explore available research that addresses the impact of exercise and physical activity on autonomic dysfunction, cognitive impairment, and sleep disorders in Parkinson's disease and suggest areas in need of further study...
November 30, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29187205/combined-double-chambered-right-ventricle-tricuspid-valve-dysplasia-ventricular-septal-defect-and-subaortic-stenosis-in-a-dog
#16
Iuliu Scurtu, Flaviu Tabaran, Mircea Mircean, Gavril Giurgiu, Andras Nagy, Cornel Catoi, Dan G Ohad
BACKGROUND: Double chambered right ventricle (DCRV) is a congenital heart anomaly where the right ventricle is divided into two chambers. We describe, for the first time, an unusual combination of DCRV combined with some other congenital heart defects. CASE PRESENTATION: A 1.2-year-old Golden Retriever was presented with lethargy, exercise intolerance and ascites. Physical examination revealed an irregularly irregular pulse and a grade V/VI, systolic, right cranial murmur...
November 29, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29174367/exercising-with-blocked-muscle-glycogenolysis-adaptation-in-the-mcardle-mouse
#17
Tue L Nielsen, Tomàs Pinós, Astrid Brull, John Vissing, Thomas O Krag
BACKGROUND: McArdle disease (glycogen storage disease type V) is an inborn error of skeletal muscle metabolism, which affects glycogen phosphorylase (myophosphorylase) activity leading to an inability to break down glycogen. Patients with McArdle disease are exercise intolerant, as muscle glycogen-derived glucose is unavailable during exercise. Metabolic adaptation to blocked muscle glycogenolysis occurs at rest in the McArdle mouse model, but only in highly glycolytic muscle. However, it is unknown what compensatory metabolic adaptations occur during exercise in McArdle disease...
November 21, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29167119/revisiting-the-physiological-effects-of-exercise-training-on-autonomic-regulation-and-chemoreflex-control-in-heart-failure-does-ejection-fraction-matter
#18
David Cristobal Andrade, Alexis Arce-Alvarez, Camilo Toledo, Hugo S Diaz, Claudia Lucero, Rodrigo Quintanilla, Harold D Schultz, Noah J Marcus, Markus Amman, Rodrigo Del Rio
Heart failure (HF) is a global public health problem that, independent of its etiology (reduced (HFrEF) or preserved ejection fraction (HFpEF)), is characterized by functional impairments of cardiac function, chemoreflex hypersensitivity, baroreflex sensitivity (BRS) impairment, and abnormal autonomic regulation, all of which contribute to increased morbidity and mortality. Exercise training (ExT) has been identified as a nonpharmacological therapy capable of restoring normal autonomic function and improving survival in patients with HFrEF...
November 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29163186/a-high-fat-diet-during-adolescence-in-male-rats-negatively-programs-reproductive-and-metabolic-function-which-is-partially-ameliorated-by-exercise
#19
Carlos A Ibáñez, Rafaela P Erthal, Fernanda M Ogo, Maria N C Peres, Henrique R Vieira, Camila Conejo, Laize P Tófolo, Flávio A Francisco, Sandra da Silva Silveira, Ananda Malta, Audrei Pavanello, Isabela P Martins, Paulo H O da Silva, Lucas Paulo Jacinto Saavedra, Gessica D Gonçalves, Veridiana M Moreira, Vander S Alves, Claudinéia C da Silva Franco, Carina Previate, Rodrigo M Gomes, Renan de Oliveira Venci, Francielle R S Dias, James A Armitage, Elena Zambrano, Paulo C F Mathias, Glaura S A Fernandes, Kesia Palma-Rigo
An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high in fat during the peri-pubertal period can have longstanding programmed effects on reproductive function and gonadal structure. This study examined metabolic and reproductive function in obese rats programmed by exposure to a high fat (HF) diet during adolescence. The effect of physical training (Ex) in ameliorating this phenotype was also assessed. Thirty-day-old male Wistar rats were fed a HF diet (35% lard w/w) for 30 days then subsequently fed a normal fat diet (NF) for a 40-day recovery period...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#20
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
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