keyword
MENU ▼
Read by QxMD icon Read
search

elimination disorders

keyword
https://www.readbyqxmd.com/read/29667182/breathing-regulation-and-blood-gas-homeostasis-after-near-complete-lesions-of-the-retrotrapezoid-nucleus-in-adult-rats
#1
George M P R Souza, Roy Kanbar, Daniel S Stornetta, Stephen B G Abbott, Ruth L Stornetta, Patrice G Guyenet
The retrotrapezoid nucleus (RTN) is one of several CNS nuclei that contribute, in various capacities (e.g. CO2 detection, neuronal modulation) to the central respiratory chemoreflex (CRC). Here we test how important the RTN is to PCO2 homeostasis and breathing during sleep or wake. RTN Nmb positive neurons were killed with targeted microinjections of substance-P-saporin conjugate in adult rats. Under normoxia, rats with large RTN lesions (92 ± 4 % cell loss) had normal blood pressure (BP) and arterial pH but were hypoxic (-8 mmHg PaO2 ) and hypercapnic (+10 mmHg PaCO2 )...
April 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29656792/training-children-aged-5-10-years-in-manual-compliance-control-to-improve-drawing-and-handwriting
#2
Geoffrey P Bingham, Winona Snapp-Childs
A large proportion of school-aged children exhibit poor drawing and handwriting. This prevalence limits the availability of therapy. We developed an automated method for training improved manual compliance control and relatedly, prospective control of a stylus. The approach included a difficult training task, while providing parametrically modifiable support that enables the children to perform successfully while developing good compliance control. The task was to use a stylus to push a bead along a 3D wire path...
April 12, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29653206/late-effects-screening-guidelines-after-hematopoietic-cell-transplantation-hct-for-hemoglobinopathy-consensus-statement-from-the-second-pediatric-blood-and-marrow-transplant-consortium-international-conference-on-late-effects-after-pediatric-hct
#3
Shalini Shenoy, Javid Gaziev, Emanuele Angelucci, Allison King, Monica Bhatia, Angela Smith, Dorine Bresters, Anne E Haight, Christine N Duncan, Josu de la Fuente, Andrew C Dietz, K Scott Baker, Michael A Pulsipher, Mark C Walters
Allogeneic hematopoietic cell transplantation (HCT) can halt organ damage and eliminate symptoms in hemoglobin disorders, including sickle cell disease (SCD) and thalassemia major (TM). Managing the residual manifestations of pre-HCT disease complications and the long-term effects of HCT requires systematic monitoring, follow-up, and intervention when indicated. Late complications vary with age and disease status at HCT, and with transplant variables such as preparative regimen, donor source and compatibility, and immune reconstitution...
April 10, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29644584/cost-effectiveness-of-universal-or-high-risk-screening-compared-to-surveillance-monitoring-in-autism-spectrum-disorder
#4
Tracy Yuen, Melissa T Carter, Peter Szatmari, Wendy J Ungar
The American Academy of Pediatrics recommends universal screening for autism spectrum disorder at 18 and 24 months. This study compared the cost-effectiveness of universal or high-risk screening to surveillance monitoring. Simulation models estimated the costs and outcomes from birth to age 6 years. The incremental cost per child diagnosed by 36 months was $41,651.6 for high-risk screening and $757,116.9 for universal screening from the societal perspective. Universal screening may not be a cost-effective approach to increase earlier treatment initiation, as most children initiated treatment after age 60 months...
April 11, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29627659/management-of-amanita-phalloides-poisoning-a-literature-review-and-update
#5
REVIEW
Yongzhuang Ye, Zhenning Liu
Amanita phalloides poisoning with a high mortality is a serious health problem in the world. The typical clinical manifestations are usually characterized by the absence of any symptoms followed by severe gastrointestinal disorders and acute liver failure. Inhibition of RNA polymeraseII (RNAP II) activity, apoptosis, and oxidative stress are considered as the major mechanism of amatoxins intoxication. The current treatment measures mainly include prevention of amatoxins absorption, elimination of absorbed amatoxins, potential antidotes therapy, and liver transplantation...
March 28, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29623043/developmental-ethanol-exposure-causes-reduced-feeding-and-reveals-a-critical-role-for-neuropeptide-f-in-survival
#6
Amanda Guevara, Hillary Gates, Brianna Urbina, Rachael French
Food intake is necessary for survival, and natural reward circuitry has evolved to help ensure that animals ingest sufficient food to maintain development, growth, and survival. Drugs of abuse, including alcohol, co-opt the natural reward circuitry in the brain, and this is a major factor in the reinforcement of drug behaviors leading to addiction. At the junction of these two aspects of reward are alterations in feeding behavior due to alcohol consumption. In particular, developmental alcohol exposure (DAE) results in a collection of physical and neurobehavioral disorders collectively referred to as Fetal Alcohol Spectrum Disorder (FASD)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29622825/gastrointestinal-food-allergy-in-ghanaian-children-a-case-series
#7
Taiba J Afaa, Adwoa Ka Afrane, Victor Etwire
Background: Food allergy is an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food allergies are classified into three types: Ig(immunoglobulin)E mediated, mixed IgE and cell mediated and cell-mediated non IgE mediated. Gastrointestinal (GIT) food allergy has classically encompassed a number of different clinical entities: food protein-induced enterocolitis syndrome (FPIES), food protein-induced proctocolitis (FPIP), food protein-induced enteropathy and eosinophilic gastrointestinal disorders (EGID)...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29618972/an-inflammation-centric-view-of-neurological-disease-beyond-the-neuron
#8
REVIEW
Stephen D Skaper, Laura Facci, Morena Zusso, Pietro Giusti
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. Inflammation in the nervous system ("neuroinflammation"), especially when prolonged, can be particularly injurious. While inflammation per se may not cause disease, it contributes importantly to disease pathogenesis across both the peripheral (neuropathic pain, fibromyalgia) and central [e...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29618580/oxidative-stress-inhibits-healthy-adipose-expansion-through-suppression-of-srebf1-mediated-lipogenic-pathway
#9
Yosuke Okuno, Atsunori Fukuhara, Erika Hashimoto, Hironori Kobayashi, Sachiko Kobayashi, Michio Otsuki, Iichiro Shimomura
Recent studies have emphasized the association of adipose oxidative stress (Fat ROS) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivo remain unclear because no mouse model has been available in which oxidative stress is manipulated targeting adipocytes. In this research, we generated two models of Fat ROS-manipulated mice and evaluated the metabolic features in diet-induced obesity. Fat ROS-eliminated mice in which Cat and Sod1 were overexpressed in adipocytes exhibited adipose expansion with decreased ectopic lipid accumulation and improved insulin sensitivity...
April 4, 2018: Diabetes
https://www.readbyqxmd.com/read/29616818/magnetic-sponge-behavior-via-electronic-state-modulations
#10
Jun Zhang, Wataru Kosaka, Kunihisa Sugimoto, Hitoshi Miyasaka
A reversible magnetic change in response to external stimuli is a desired function of molecular magnetic materials. The magnetic change induced by a change in the intrinsic spin is significant because the magnetic change is inevitable and could become drastic. In this study, we demonstrate a reversible magnetic change closely associated with electronic state modulations, as well as structural modifications realized by solvation/desolvation cycles of a magnetic sponge. The compound was a D2A-type-layered magnet, [{Ru2(O2CPh-2,3,5-Cl3)4}2(TCNQMe2)]·4DCM (1; 2,3,5-Cl3PhCO2- = 2,3,5-trichlorobenzoate; TCNQMe2 = 2,5-dimethyl-7,7,8,8-tetracyanoquinodimethane, DCM = dichloromethane), where [Ru2(O2CPh-2,3,5-Cl3)4] ([Ru2II,II]) is an electron-donor (D) and TCNQMe2 is an electron-acceptor (A)...
April 4, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29609039/computer-aided-diagnosis-of-cavernous-malformations-in-brain-mr-images
#11
Huiquan Wang, S Nizam Ahmed, Mrinal Mandal
Cavernous malformation or cavernoma is one of the most common epileptogenic lesions. It is a type of brain vessel abnormality that can cause serious symptoms such as seizures, intracerebral hemorrhage, and various neurological disorders. Manual detection of cavernomas by physicians in a large set of brain MRI slices is a time-consuming and labor-intensive task and often delays diagnosis. In this paper, we propose a computer-aided diagnosis (CAD) system for cavernomas based on T2-weighted axial plane MRI image analysis...
June 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29608128/prenatal-and-postnatal-mother-to-child-transmission-of-acculturation-s-health-effects-in-hispanic-americans
#12
Molly Fox, Zaneta M Thayer, Isabel F Ramos, Sarah J Meskal, Pathik D Wadhwa
BACKGROUND: Hispanic Americans consistently exhibit an intergenerational increase in the prevalence of many noncommunicable chronic physical and mental disorders. METHODS: We review and synthesize evidence suggesting that a constellation of prenatal and postnatal factors may play crucial roles in explaining this trend. We draw from relevant literature across several disciplines, including epidemiology, anthropology, psychology, medicine (obstetrics, neonatology), and developmental biology...
April 2, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29607682/epileptic-seizure-detection-based-on-time-frequency-images-of-eeg-signals-using-gaussian-mixture-model-and-gray-level-co-occurrence-matrix-features
#13
Yang Li, Weigang Cui, Meilin Luo, Ke Li, Lina Wang
The electroencephalogram (EEG) signal analysis is a valuable tool in the evaluation of neurological disorders, which is commonly used for the diagnosis of epileptic seizures. This paper presents a novel automatic EEG signal classification method for epileptic seizure detection. The proposed method first employs a continuous wavelet transform (CWT) method for obtaining the time-frequency images (TFI) of EEG signals. The processed EEG signals are then decomposed into five sub-band frequency components of clinical interest since these sub-band frequency components indicate much better discriminative characteristics...
January 25, 2018: International Journal of Neural Systems
https://www.readbyqxmd.com/read/29607397/initial-experience-with-a-novel-resection-and-plication-rap-method-for-acid-reflux-a-pilot-study
#14
Petros C Benias, Lionel D'Souza, Gloria Lan, Craig Gluckman, Sumant Inamdar, Arvind J Trindade, Larry S Miller, David L Carr-Locke
Background and study aims:  Current endoscopic therapies for gastroesophageal reflux disorder (GERD) are limited by technical complexity, and/or cost. We sought to evaluate the success of a novel resection and plication (RAP) anti-reflux procedure. Patients and methods:  RAP was performed on 10 patients with GERD refractory to proton pump inhibitor (PPI) therapy. RAP consists of semi-circumferential mucosectomy along with full-thickness plication of the lower esophageal sphincter (LES) and cardia...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29606819/disseminated-superficial-actinic-porokeratosis-in-a-patient-with-psoriasis-after-long-term-narrowband-ultraviolet-b-phototherapy
#15
Chang Yoon Sim, Ji Yeoun Shin, Sung Yul Lee, Young Lip Park
Porokeratosis is a rare epidermal disorder characterized by annular or linear hyperkeratotic plaques with slightly raised thread-like borders, and in most cases, atrophic centers. Disseminated superficial porokeratosis and disseminated superficial actinic porokeratosis (DSAP), which primarily involve sun-exposed areas, are common types of porokeratoses. Histologically, a column of parakeratotic cells, a so-called cornoid lamella, is a hallmark of porokeratosis. Porokeratosis is considered to result from the inability to eliminate an abnormal keratinocyte clone induced by genetic factors and various stimuli, including sunlight, artificial ultraviolet light, viral infections, immunosuppressive conditions (hematologic malignancies, organ transplants, or autoimmune disease), and immunosuppressive therapies...
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29604978/neuropathogenesis-of-human-immunodeficiency-virus-infection
#16
Brady Sillman, Christopher Woldstad, Joellyn Mcmillan, Howard E Gendelman
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) remain a common end-organ manifestation of viral infection. Subclinical and mild symptoms lead to neurocognitive and behavioral abnormalities. These are associated, in part, with viral penetrance and persistence in the central nervous system. Infections of peripheral blood monocytes, macrophages, and microglia are the primary drivers of neuroinflammation and neuronal impairments. While current antiretroviral therapy (ART) has reduced the incidence of HIV-associated dementia, milder forms of HAND continue...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29604878/spectrally-resolved-single-molecule-electrometry
#17
F Ruggeri, M Krishnan
Escape-time electrometry is a recently developed experimental technique that offers the ability to measure the effective electrical charge of a single biomolecule in solution with sub-elementary charge precision. The approach relies on measuring the average escape-time of a single charged macromolecule or molecular species transiently confined in an electrostatic fluidic trap. Comparing the experiments with the predictions of a mean-field model of molecular electrostatics, we have found that the measured effective charge even reports on molecular conformation, e...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29595146/assessment-of-linear-and-nonlinear-complex-heartbeat-dynamics-in-subclinical-depression-dysphoria
#18
Alberto Greco, Simone Messerotti Benvenuti, Claudio Gentili, Daniela Palomba, Enzo Pasquale Scilingo, Gaetano Valenza
OBJECTIVE: Depression is one of the leading causes of disability worldwide. Most previous studies have focused on major depression, and studies on subclinical depression, such as those on so-called dysphoria, have been overlooked. Indeed, dysphoria is associated with a high prevalence of somatic disorders, and a reduction of quality of life and life expectancy. In current clinical practice, dysphoria is assessed using psychometric questionnaires and structured interviews only, without taking into account objective pathophysiological indices...
March 29, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29593838/b-cell-based-therapies-in-cns-autoimmunity-differentiating-cd19-and-cd20-as-therapeutic-targets
#19
REVIEW
Thomas G Forsthuber, Daniel M Cimbora, John Nolan Ratchford, Eliezer Katz, Olaf Stüve
Increasing recognition of the role of B cells in the adaptive immune response makes B cells an important therapeutic target in autoimmunity. Numerous current and developmental immunotherapies target B cells for elimination through recognition of cell-surface proteins expressed specifically on B cells, in particular CD19 and CD20. Similarities and differences in the function and expression of these two molecules predict some shared, and some distinct, pharmacological effects of agents targeting CD19 versus CD20, potentially leading to differences in the clinical safety and efficacy of such agents...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29593638/tourette-syndrome-a-mini-review
#20
REVIEW
Michal Novotny, Martin Valis, Blanka Klimova
The purpose of this mini-review is to provide the latest information on epidemiology, pathophysiology, diagnosis, and treatment of Tourette syndrome (TS). The authors conducted a literature search of available sources describing the issue of tic disorders with special focus on TS and made a comparison and evaluation of relevant findings. The results of this mini-review indicate that TS is a complex disorder, which has a significant impact on the quality of life of both the patients and his/her family. Therefore, early and proper diagnosis and treatment are necessary in order to reduce or even eliminate both symptoms and social burden of the patient...
2018: Frontiers in Neurology
keyword
keyword
98659
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"