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https://www.readbyqxmd.com/read/15768566/approach-to-clinical-trial-considering-medical-ethics-and-efficacy-for-hbv-liposome-encapsulated-hemoglobin-vesicle
#1
REVIEW
Masuhiko Takaori
Since around 1985, a liposome encapsulated hemoglobin vesicle (HbV) has been developed in Waseda University as an artificial red cell. Subsequently, in 1995, Terumo Co. produced a prototype of HbV for clinical trial, the so-called Neo Red Cell. We tested this in preclinical study and believed firmly that infusion of the HbV could substitute for ordinary blood transfucion. Subsequently, further improvement was done on the HbV by investigators of Waseda and Keio University supported by a grant of Health & Welfare Ministry, Japan, and recent physicochemical properties of the HbV are evaluated, mostly applicable for clinical trial...
2005: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
https://www.readbyqxmd.com/read/10819045/-immunological-mechanisms-of-the-radioprotective-effects-of-ceruloplasmin
#2
O F Seniuk, A A Revina, P D Tarasenko, I F Kovalev, K V Seniuk, S N Korzh
The aim of the work was to examine immunotropic features of celluroplasmine++ (Cp) and estimate its capacity as radioprotector. The pulse radiolysis method was used to set the mechanism of elementary reactions, which were responsible for antioxidant activity, and to demonstrate a particular role of reversible oxycomplexis, Cp...O2. Within in vitro test-systems the effects of Cp were examined on the model of interaction between lymphocytes from Shelter staff which constantly contacts with ionizing irradiation, and autologous erythrocytes in rosset-forming phenomenon (223 Shelter employees in comparison with 253 donors of Kyiv blood transfucion station)...
March 2000: Radiatsionnaia Biologiia, Radioecologiia
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