Luise Schultz, Marie-Gabrielle Zurich, Maxime Culot, Anaelle da Costa, Christophe Landry, Patricia Bellwon, Theresa Kristl, Katrin Hörmann, Silke Ruzek, Stephan Aiche, Knut Reinert, Chris Bielow, Fabien Gosselet, Romeo Cecchelli, Christian G Huber, Olaf H-U Schroeder, Alexandra Gramowski-Voss, Dieter G Weiss, Anna Bal-Price
The present study was performed in an attempt to develop an in vitro integrated testing strategy (ITS) to evaluate drug-induced neurotoxicity. A number of endpoints were analyzed using two complementary brain cell culture models and an in vitro blood-brain barrier (BBB) model after single and repeated exposure treatments with selected drugs that covered the major biological, pharmacological and neuro-toxicological responses. Furthermore, four drugs (diazepam, cyclosporine A, chlorpromazine and amiodarone) were tested more in depth as representatives of different classes of neurotoxicants, inducing toxicity through different pathways of toxicity...
December 25, 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA