Read by QxMD icon Read

amiodarone neurotoxicity

Maria López Brunsó, Cristina Toro Blanch, Elia Sais Girona, Diana Roa García, Alejandro Hernández Martínez, Angel Izquierdo Font, Silvia Guerra Prió, Huber Gunter Mas Pueyo, Joaquim Bosch-Barrera
Drug-drug interactions (DDIs) are of great concern in the treatment of cancer, especially when target therapies, such as tyrosine kinase inhibitors, are being used. Here, we report a case of probable DDI between erlotinib and amiodarone leading to severe neurotoxicity. Amiodarone inhibits P-glycoprotein (P-gp), for which erlotinib is a substrate. P-gp is an important drug transporter that is involved in limiting the blood-brain barrier penetration of erlotinib. Clinicians should be aware of emerging data characterizing the effect of the P-gp transport system on drug exposure and its potential for DDI...
April 2018: Anti-cancer Drugs
Luise Schultz, Marie-Gabrielle Zurich, Maxime Culot, Anaelle da Costa, Christophe Landry, Patricia Bellwon, Theresa Kristl, Katrin Hörmann, Silke Ruzek, Stephan Aiche, Knut Reinert, Chris Bielow, Fabien Gosselet, Romeo Cecchelli, Christian G Huber, Olaf H-U Schroeder, Alexandra Gramowski-Voss, Dieter G Weiss, Anna Bal-Price
The present study was performed in an attempt to develop an in vitro integrated testing strategy (ITS) to evaluate drug-induced neurotoxicity. A number of endpoints were analyzed using two complementary brain cell culture models and an in vitro blood-brain barrier (BBB) model after single and repeated exposure treatments with selected drugs that covered the major biological, pharmacological and neuro-toxicological responses. Furthermore, four drugs (diazepam, cyclosporine A, chlorpromazine and amiodarone) were tested more in depth as representatives of different classes of neurotoxicants, inducing toxicity through different pathways of toxicity...
December 25, 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA
S Vichi, J Sandström von Tobel, S Gemma, S Stanzel, A Kopp-Schneider, F Monnet-Tschudi, E Testai, M G Zurich
Within the Predict-IV FP7 project a strategy for measurement of in vitro biokinetics was developed, requiring the characterization of the cellular model used, especially regarding biotransformation, which frequently depends on cytochrome P450 (CYP) activity. The extrahepatic in situ CYP-mediated metabolism is especially relevant in target organ toxicity. In this study, the constitutive mRNA levels and protein localization of different CYP isoforms were investigated in 3D aggregating brain cell cultures. CYP1A1, CYP2B1/B2, CYP2D2/4, CYP2E1 and CYP3A were expressed; CYP1A1 and 2B1 represented almost 80% of the total mRNA content...
December 25, 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Chr van Tellingen
Two patients presented with a rather unusual form and documentation of amiodarone toxicity. General aspects on this topic are addressed with emphasis on neurotoxicity and pulmonary disease. The need for rational prescribing and a scrupulous follow-up is stressed in view of apparent unawareness of general physicians and organ-related specialists alike regarding these very phenomena.
October 2004: Netherlands Heart Journal
Giuliana Pomponio, Marie-Gabrielle Zurich, Luise Schultz, Dieter G Weiss, Luca Romanelli, Alexandra Gramowski-Voss, Emma Di Consiglio, Emanuela Testai
The difficulty in mimicking nervous system complexity and cell-cell interactions as well as the lack of kinetics information has limited the use of in vitro neurotoxicity data. Here, we assessed the biokinetic profile as well as the neurotoxicity of Amiodarone after acute and repeated exposure in two advanced rodent brain cell culture models, consisting of both neurons and glial cells organized in 2 or 3 dimensions to mimic the brain histiotypic structure and function. A strategy was applied to evidence the abiotic processes possibly affecting Amiodarone in vitro bioavailability, showing its ability to adsorb to the plastic devices...
December 25, 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Jonathan Nicolas, Peter J M Hendriksen, Laura H J de Haan, Rosella Koning, Ivonne M C M Rietjens, Toine F H Bovee
The present study investigated if and to what extent murine stem cell-derived beating cardiomyocytes within embryoid bodies can be used as a broad screening in vitro assay for neurotoxicity testing, replacing for example in vivo tests for marine neurotoxins. Effect of nine model compounds, acting on either the Na(+), K(+), or Ca(2+) channels or the Na(+)/K(+) ATP-ase pump, on the beating was assessed. Diphenhydramine, veratridine, isradipine, verapamil and ouabain induced specific beating arrests that were reversible and none of the concentrations tested induced cytotoxicity...
March 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Vinod K Chaubey, Lovely Chhabra, Aaysha Kapila
A 79-year-old woman presented with lower extremity weakness and unsteadiness for 2 weeks. She was recently diagnosed with refractory atrial flutter and was prescribed amiodarone. Physical examination revealed signs of cerebellar dysfunction. Neuroimaging including CT and MRI were unremarkable. Her hospital course included the development of ventricular tachycardia necessitating increment in amiodarone dose. Laboratory studies were unremarkable except mild transaminitis. Other workup including the one for paraneoplastic neurological involvement was negative...
September 26, 2013: BMJ Case Reports
Aruna T Nathan, Maryam Naim, Lisa M Montenegro, Victoria L Vetter
Long QT syndrome is characterized by electrocardiographic appearance of long QT intervals and propensity to polymorphic ventricular tachycardia. Aggressive anticipatory clinical management is required for a good outcome, especially in the symptomatic neonate. We present a neonate with a compound mutation with refractory ventricular tachycardia that necessitated multimodal pharmacotherapy with lidocaine, esmolol, and amiodarone along with ventricular pacing. Despite normal serum lidocaine levels, complex pharmacokinetic interactions resulted in presumed neurotoxicity due to lidocaine...
February 2012: Anesthesia and Analgesia
S Ishida, M Sugino, T Hosokawa, T Sato, D Furutama, A Fukuda, F Kimura, H Kuwabara, Y Shibayama, T Hanafusa
BACKGROUND: Amiodarone-induced hepatotoxicity consists of mild liver test abnormalities and rare cases of acute hepatitis and chronic hepatic lesions, and histologically resembles the whole spectrum of alcoholic liver disease, i.e., non-alcoholic steatohepatitis. Amiodarone-induced neurotoxicity, including tremor, ataxia and peripheral neuropathy, is known, and some cases of parkinsonism following amiodarone use have also been reported. OBJECTIVE: To study the pathology of amiodarone-associated parkinsonism...
March 2010: Clinical Neuropathology
Carolyn F Orr, J Eric Ahlskog
OBJECTIVE: To assess the incidence, severity, and spectrum of neurologic toxic effects associated with administration of amiodarone hydrochloride. DESIGN: Retrospective medical record analysis of cardiac patients treated with amiodarone between January 1, 1996, and July 31, 2008. SETTING: Residents of Olmsted County, Minnesota, treated at the Mayo Clinic. PATIENTS: The Mayo Clinic medical records of all adult Olmsted County residents prescribed amiodarone between January 1, 1996, and July 31, 2008, were reviewed and all possible neurologic adverse effects that might be attributable to amiodarone were tabulated...
July 2009: Archives of Neurology
Thomas Y K Chan
INTRODUCTION: Aconitine and related alkaloids found in the Aconitum species are highly toxic cardiotoxins and neurotoxins. The wild plant (especially the roots and root tubers) is extremely toxic. Severe aconite poisoning can occur after accidental ingestion of the wild plant or consumption of an herbal decoction made from aconite roots. In traditional Chinese medicine, aconite roots are used only after processing to reduce the toxic alkaloid content. Soaking and boiling during processing or decoction preparation will hydrolyze aconite alkaloids into less toxic and non-toxic derivatives...
April 2009: Clinical Toxicology
Mina S Willis, Amy M Lugo
PURPOSE: A case of amiodarone-induced neurotoxicity is reported. SUMMARY: A 76-year-old man arrived at the emergency department with complaints of increasing imbalance over the past 2.5 months after a recent discharge from the hospital. He reported that his balance had worsened over the past week and that he now must use a cane to walk. His medical history included coronary artery disease, peripheral vascular disease, hypertension, hyperlipidemia, and paroxysmal atrial fibrillation...
March 15, 2009: American Journal of Health-system Pharmacy: AJHP
Alp Arkun, Shawn K Van Deusen, Timothy Grau, Robert H Birkhahn
BACKGROUND: Amiodarone is commonly used in the treatment of refractory paroxysmal atrial fibrillation. Much of the literature focuses on the toxic effects of this medication in the setting of rapid loading or long-term therapy with high maintenance doses. However, patients have been known to develop multi-organ toxicities with long-term low-dose therapy. CASE REPORT: We present a 90-year-old man with paroxysmal atrial fibrillation undergoing low-dose amiodarone therapy for a period of 18 months without medical follow-up who developed signs and symptoms consistent with neurotoxicity and hepatotoxicity in association with hyperammonemia...
April 2010: Journal of Emergency Medicine
Geneviève Durrieu, Isabelle Lacroix, Pascale Olivier, Agnès Sommet, Jean-Michel Sénard, Jean-Louis Montastruc
INTRODUCTION: Drug-induced neuropathies are mainly sensory and subacute. The pathophysiological mechanisms associated with them are not clearly established and few pharmacoepidemiologic studies are available. METHOD: This study investigated spontaneous reports of peripheral neuropathies reported to the French Adverse Drug Reaction (pharmacovigilance) database over a ten-year period. RESULTS: Between January 1995 and April 2005, 1110 cases were reported, predominantly among men (60%)...
June 2008: La Presse Médicale
Hyun Mo Kang, Yoon Sae Kang, Seok Hyun Kim, Jae Kyu Seong, Dae Young Kang, Heon Young Lee, Byung Seok Lee
Amiodarone chlorhydrate is a diiodated benzofuran derivative, and it is used to treat cardiac rhythm abnormalities. Hepatotoxicity is a relatively uncommon side effect of amiodarone, and symptomatic hepatic dysfunction occurs in fewer than 1% of the patients taking amiodarone. Cirrhosis is a rare complication that's been confirmed in 12 cases. Peripheral neuropathy occurs in 10% of patients taking aminodarone. We report here on an unusual case of amiodarone-induced hepatotoxicity and peripheral neurotoxicity...
September 2007: Korean Journal of Internal Medicine
Debasis Bagchi, Manashi Bagchi, Sidney j Stohs, Sidhatha D Ray, Chandan K Sen, Harry G Preuss
Grape seed proanthocyanidins have been reported to possess a broad spectrum of pharmacological and medicinal properties against oxidative stress. We have demonstrated that IH636 proanthocyanidin extract (GSPE) provides excellent protection against free radicals in both in vitro and in vivo models. GSPE had significantly better free radical scavenging ability than vitamins C, E and beta-carotene and demonstrated significant cytotoxicity towards human breast, lung and gastric adenocarcinoma cells, while enhancing the growth and viability of normal cells...
May 2002: Annals of the New York Academy of Sciences
D Bagchi, S D Ray, D Patel, M Bagchi
Grape seed proanthocyanidins have been demonstrated to exhibit a broad spectrum of pharmacological, therapeutic and chemoprotective properties. In our previous studies, IH636 grape seed proanthocyanidin extract (GSPE, commercially known as ActiVin) demonstrated excellent concentration- and dose-dependent free radical scavenging abilities in both in vitro and in vivo models and provided significantly better protection than vitamins C, E and beta-carotene. GSPE demonstrated significant cytotoxicity towards human breast, lung and gastric adenocarcinoma cells, while enhancing the growth and viability of normal human gastric mucosal cells and macrophage J774A...
2001: Drugs Under Experimental and Clinical Research
L Bartalena, F Bogazzi, L E Braverman, E Martino
Amiodarone, a benzofuranic derivative, iodine-rich drug, has been used in pregnancy for either maternal or fetal tachyarrhythmias. Amiodarone, its main metabolite (desethylamiodarone) and iodine are transferred, albeit incompletely, through the placenta, resulting in a relevant fetal exposure to the drug and iodine overload. Since the fetus acquires the capacity to escape from the acute Wolff-Chaikoff effect only late in gestation, the iodine overload may cause fetal/neonatal hypothyroidism and goiter. Among the reported 64 pregnancies in which amiodarone was given to the mother, 11 cases (17%) of hypothyroidism in the progeny (10 detected at birth, 1 in utero) were reported, 9 non-goitrous (82%) and 2 (18%) associated with goiter...
February 2001: Journal of Endocrinological Investigation
L A Magee, I Nulman, J F Rovet, G Koren
It is not known whether amiodarone is neurotoxic to the fetus, as it is to adults. We evaluated neurodevelopment of a historical cohort (N = 10) of children exposed transplacentally to amiodarone. Scores on standardized tests of cognitive and language skills were compared (by Wilcoxon signed rank test) between eight toddlers and matched controls. It was not possible to obtain controls for older amiodarone-exposed children (aged 9.7 and 12.0 years), whose test results were compared descriptively with normative data...
May 1999: Neurotoxicology and Teratology
P H Katrak
This report describes two patients with recent stroke who, upon transfer to the rehabilitation medicine service, were noted to have extrapyramidal features. Both patients were receiving amiodarone for management of atrial fibrillation. When this medication was discontinued, there was slow resolution of extrapyramidal features and an improvement in function. Physicians managing acute stroke patients should be alert for features of amiodarone neurotoxicity, because these side effects may occur more readily in patients with recent neurologic impairment and may impede their progress in rehabilitation...
January 1999: Archives of Physical Medicine and Rehabilitation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"