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https://www.readbyqxmd.com/read/27914132/associations-between-soluble-receptor-for-advanced-glycation-end-products-srage-and-s100a12-en-rage-with-mortality-in-long-term-hemodialysis-patients
#1
Eul Sik Jung, Wookyung Chung, Ae Jin Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Ji Yong Jung
Hemodialysis (HD) patients experience vascular calcification, ultimately leading to high mortality rates. Previously, we reported associations between soluble receptor for advanced glycation end products (sRAGEs) and extracellular newly identified RAGE-binding protein S100A12 (EN-RAGE) and vascular calcification. Here, we extended our observations, investigating whether these biomarkers may be useful for predicting cardiovascular morbidity and mortality in these subjects. Thus, we evaluated the relationship between sRAGE and S100A12 and mortality in long-term HD patients...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27913191/the-shedding-derived-soluble-receptor-for-advanced-glycation-endproducts-sustains-inflammation-during-acute-pseudomonas-aeruginosa-lung-infection
#2
Antonella Antonelli, Stefania Di Maggio, Joanna Rejman, Francesca Sanvito, Alice Rossi, Alessandro Catucci, Andrea Gorzanelli, Alessandra Bragonzi, Marco E Bianchi, Angela Raucci
BACKGROUND: The membrane-bound isoform of the receptor for advanced glycation end products (FL-RAGE) is primarily expressed by alveolar epithelial cells and undergoes shedding by the protease ADAM10, giving rise to soluble cleaved RAGE (cRAGE). RAGE has been associated with the pathogenesis of several acute and chronic lung disorders. Whether the proteolysis of FL-RAGE is altered by a given inflammatory stimulus is unknown. Pseudomonas aeruginosa causes nosocomial infections in hospitalized patients and is the major pathogen associated with chronic lung diseases...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27883367/a-drop-in-the-circulating-concentrations-of-soluble-receptor-for-ages-is-associated-with-seroconversion-to-autoantibody-positivity-but-not-with-subsequent-progression-to-clinical-disease-in-children-en-route-to-type-1-diabetes
#3
K M Salonen, S J Ryhänen, J M Forbes, T Härkönen, J Ilonen, O Simell, R Veijola, P-H Groop, M Knip
BACKGROUND: Advanced glycation end products (AGEs) and their interaction with the receptor for advanced glycation end products (RAGE) have been studied for their role in the pathogenesis and complications of type 1 diabetes. Decreased concentrations of soluble RAGE (sRAGE) have been reported in acute autoimmune inflammation. We set out to analyze the changes in (sRAGE) concentration during preclinical diabetes in children seroconverting to islet autoantibody positivity. METHODS: We measured serum concentrations of sRAGE in 168 children who progressed to clinical disease and 43 children who turned positive for at least two diabetes-associated autoantibodies but remained non-diabetic...
November 24, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27879642/curcumin-and-boswellia-serrata-modulate-the-glyco-oxidative-status-and-lipo-oxidation-in-master-athletes
#4
Nino Cristiano Chilelli, Eugenio Ragazzi, Romina Valentini, Chiara Cosma, Stefania Ferraresso, Annunziata Lapolla, Giovanni Sartore
BACKGROUND: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists. METHODS: Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group)...
November 21, 2016: Nutrients
https://www.readbyqxmd.com/read/27873077/impaired-osteogenic-differentiation-and-enhanced-cellular-receptor-of-advanced-glycation-end-products-sensitivity-in-patients-with-type-2-diabetes
#5
Mattabhorn Phimphilai, Peraphan Pothacharoen, Prachya Kongtawelert, Nipon Chattipakorn
Preclinical studies have demonstrated impaired osteoblast differentiation in type 2 diabetes (T2DM), which is related to skeletal accumulation of advanced glycation end products (AGEs). However, the role of AGE in osteoblast differentiation in patients with T2DM is unclear. This cross-sectional study was performed to investigate osteoblast differentiation and its association with serum pentosidine and soluble receptor of AGEs (sRAGE). Twenty-seven patients with T2DM and 15 age-matched controls were included to measure sRAGE and osteogenic differentiation in mononuclear cells derived from peripheral blood...
November 21, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27865475/soluble-receptor-for-advanced-glycation-end-products-quantifies-lung-injury-in-polytraumatized-patients
#6
Lukas L Negrin, Gabriel Halat, Helmut Prosch, Michael Hüpfl, Stefan Hajdu, Thomas Heinz
BACKGROUND: Biomarkers caused by blunt chest trauma might leak into the vascular compartment and therefore reflect the severity of parenchymal lung injury (PLI). Five promising proteins were preselected after a literature scan. The objective of our study was to identify a biomarker that is released abundantly into the serum shortly after trauma and reliably quantifies the loss of functional lung tissue. METHODS: Polytraumatized patients (aged ≥18 years, Injury Severity Score [ISS] ≥16) were included in our prospective observational study if they were admitted directly to our level I trauma center during the first hour after trauma occurred...
November 16, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27830398/relationships-between-vitreous-levels-of-soluble-receptor-for-advanced-glycation-end-products-srage-and-renal-function-in-patients-with-diabetic-retinopathy
#7
Makiko Katagiri, Jun Shoji, Satoshi Kato, Shigehiko Kitano, Yasuko Uchigata
PURPOSE: We investigated the relationship between vitreous levels of soluble receptor for advanced glycation end products (sRAGE) and vascular endothelial growth factor (VEGF) and renal function, and correlations between vitreous sRAGE levels and proliferative diabetic retinopathy (PDR) activity. METHODS: We examined 33 eyes from 33 patients with diabetes mellitus who underwent a vitrectomy (eight patients in the non-PDR [NPDR] group and 25 in the PDR group). Serum creatinine levels and estimated glomerular filtration rate (eGFR) were measured and classified according to the chronic kidney disease (CKD)-staging method...
November 9, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27829696/plasma-levels-of-pentosidine-carboxymethyl-lysine-soluble-receptor-for-advanced-glycation-end-products-and-metabolic-syndrome-the-metformin-effect
#8
Mohamed Haddad, Ines Knani, Hsan Bouzidi, Olfa Berriche, Mohamed Hammami, Mohsen Kerkeni
Metabolic syndrome (MetS) is considered one of the most important public health problems. Several and controversial studies showed that the role of advanced glycation end products (AGEs) and their receptor in the development of metabolic syndrome and therapeutic pathways is still unsolved. We have investigated whether plasma pentosidine, carboxymethyl-lysine (CML), and soluble receptor for advanced glycation end products (sRAGE) levels were increased in patients with MetS and the effect of metformin in plasma levels of pentosidine, CML, and sRAGE...
2016: Disease Markers
https://www.readbyqxmd.com/read/27804999/overexpression-of-soluble-rage-in-mesenchymal-stem-cells-enhances-their-immunoregulatory-potential-for-cellular-therapy-in-autoimmune-arthritis
#9
Min-Jung Park, Seung Hoon Lee, Su-Jin Moon, Jung-Ah Lee, Eun-Jung Lee, Eun-Kyung Kim, Jin-Sil Park, Jennifer Lee, Jun-Ki Min, Seok Jung Kim, Sung-Hwan Park, Mi-La Cho
Mesenchymal stem cells (MSCs) are attractive agents for cellular therapy in rheumatoid arthritis (RA). The receptor for advanced glycation end products (RAGE) serves as a pattern recognition receptor for endogenous inflammatory ligands. Soluble RAGE (sRAGE) is a truncated form of RAGE that functions as a decoy and acts as an anti-inflammatory molecule. The aim of this study was to determine whether sRAGE has therapeutic effects and the mechanisms active in sRAGE-overexpressing MSCs (sRAGE-MSCs) in an experimental model of RA...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27766267/advanced-glycation-end-products-and-its-soluble-receptors-in-the-pathogenesis-of-thoracic-aortic-aneurysm
#10
Kailash Prasad, Abdullah Sarkar, Mohammad A Zafar, Ahmed Shoker, Hamdi Ei Moselhi, Maryann Tranquilli, Bulat A Ziganshin, John A Elefteriades
BACKGROUND: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of thoracic aortic aneurysms (TAAs). Cytokines [Interleukin (IL)-Iβ, IL-2, IL-6, and TNF-α)] increase the expression of MMP-2 and -3. Advanced glycation end products (AGEs) interact with cell receptors to increase the release of cytokines. Circulating soluble receptors for AGEs (sRAGE) and endogenous secretory RAGE (esRAGE) compete with membrane bound RAGE for binding with AGEs and reduce the production of cytokines...
February 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/27755550/the-ser82-rage-variant-affects-lung-function-and-serum-rage-in-smokers-and-srage-production-in-vitro
#11
Suzanne Miller, Amanda P Henry, Emily Hodge, Alexander K Kheirallah, Charlotte K Billington, Tracy L Rimington, Sangita K Bhaker, Ma'en Obeidat, Erik Melén, Simon K Merid, Caroline Swan, Catherine Gowland, Carl P Nelson, Ceri E Stewart, Charlotte E Bolton, Iain Kilty, Anders Malarstig, Stuart G Parker, Miriam F Moffatt, Andrew J Wardlaw, Ian P Hall, Ian Sayers
INTRODUCTION: Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Receptor (AGER, encoding RAGE). We aimed to (i) characterise RAGE expression in the lung, (ii) identify AGER transcripts, (iii) ascertain if SNP rs2070600 (Gly82Ser C/T) is associated with lung function and serum sRAGE levels and (iv) identify whether the Gly82Ser variant is functionally important in altering sRAGE levels in an airway epithelial cell model...
2016: PloS One
https://www.readbyqxmd.com/read/27754038/os-13-04-soluble-receptor-for-advanced-glycation-end-products-and-increased-aortic-stiffness-in-the-general-population
#12
Jan Filipovsky, Jitka Seidlerova, Otto Mayer, Petra Karnosova
OBJECTIVE: Accumulation of advanced glycation end-products (AGE) has been suggested to be involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, thus preventing them from binding to the cell-surface receptor (RAGE) and protecting against the RAGE-AGE axis-elicited processes. We hypothesized that low sRAGE levels might be associated with increased arterial stiffness. DESIGN AND METHOD: In a cross-sectional design, we analyzed 1077 subjects, aged 25 to 64 years, from the Czech population-based study ("Post-MONICA")...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27719648/therapeutic-interventions-for-advanced-glycation-end-products-and-its-receptor-mediated-cardiovascular-disease
#13
Kailash Prasad, Shuchita Tiwari
Advanced glycation end products (AGEs) are heterogeneous group of molecules formed from non-enzymatic reaction of reducing sugars with amino group of proteins, lipids, and nucleic acid. Interaction of AGEs with its cell-bound receptor (RAGE) results in generation of oxygen radicals, nuclear factor kappa-β, pro-inflammatory cytokines and cell adhesion molecules, and is involved in the pathophysiology of cardiovascular diseases (CVD). Circulating soluble forms of RAGE (sRAGE) and endo-secretory RAGE (esRAGE) compete with RAGE for ligand binding and function as a decoy...
October 6, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27714575/ages-srage-a-novel-risk-factor-in-the-pathogenesis-of-end-stage-renal-disease
#14
Kailash Prasad, Indu Dhar, Qifeng Zhou, Hamdi Elmoselhi, Muhammad Shoker, Ahmed Shoker
Interaction of advanced glycation end products (AGEs) with its cell-bound receptor (RAGE) results in cell dysfunction through activation of nuclear factor kappa-B, increase in expression and release of inflammatory cytokines, and generation of oxygen radicals. Circulating soluble receptors, soluble receptor (sRAGE), endogenous secretory receptor (esRAGE) and cleaved receptor (cRGAE) act as decoy for RAGE ligands and thus have cytoprotective effects. Low levels of sRAGE and esRAGE have been proposed as biomarkers for many diseases...
December 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27688824/soluble-receptor-for-advanced-glycation-end-product-ameliorates-chronic-intermittent-hypoxia-induced-renal-injury-inflammation-and-apoptosis-via-p38-jnk-signaling-pathways
#15
Xu Wu, Wenyu Gu, Huan Lu, Chengying Liu, Biyun Yu, Hui Xu, Yaodong Tang, Shanqun Li, Jian Zhou, Chuan Shao
Obstructive sleep apnea (OSA) associated chronic kidney disease is mainly caused by chronic intermittent hypoxia (CIH) triggered tissue damage. Receptor for advanced glycation end product (RAGE) and its ligand high mobility group box 1 (HMGB1) are expressed on renal cells and mediate inflammatory responses in OSA-related diseases. To determine their roles in CIH-induced renal injury, soluble RAGE (sRAGE), the RAGE neutralizing antibody, was intravenously administered in a CIH model. We also evaluated the effect of sRAGE on inflammation and apoptosis...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27679416/increased-neutrophil-expression-of-pattern-recognition-receptors-during-copd-exacerbations
#16
Simon D Pouwels, Wouter H van Geffen, Marnix R Jonker, Huib A M Kerstjens, Martijn C Nawijn, Irene H Heijink
Previously, we observed increased serum levels of damage-associated molecular patterns (DAMPs) during COPD exacerbations. Here, gene expression of DAMP receptors was measured in peripheral blood neutrophils of COPD patients during stable disease and severe acute exacerbation. The expression of toll-like receptor (TLR)2, TLR4 and NLR family, pyrin domain-containing 3 (NLRP3) was significantly increased, while serum levels of the soluble form of the decoy receptor for advanced glycation end-product (sRAGE) were decreased during exacerbation...
September 27, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27664102/follicular-fluid-plgf-sflt-1-ratio-and-soluble-receptor-for-advanced-glycation-end-products-correlate-with-ovarian-sensitivity-index-in-women-undergoing-a-r-t
#17
H R Nejabati, A Mota, L Farzadi, M Ghojazadeh, A Fattahi, K Hamdi, M Nouri
PURPOSE: Considering potential roles of soluble receptor for advanced glycation end products (sRAGE) and placental growth factor (PlGF) in ovarian function and embryo implantation, in the present study we have evaluated the association of these factors and also PlGF/sFlt-1 ratio with the ovarian response and implantation rate by dividing patients according to the OSI. METHODS: In a cross-sectional study, 90 infertile women who were undergoing ICSI cycle using long protocol were recruited...
September 23, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27642956/os-13-04-soluble-receptor-for-advanced-glycation-end-products-and-increased-aortic-stiffness-in-the-general-population
#18
Jan Filipovsky, Jitka Seidlerova, Otto Mayer, Petra Karnosova
OBJECTIVE: Accumulation of advanced glycation end-products (AGE) has been suggested to be involved in several pathophysiological processes in the vessel wall. Soluble isoform of receptor for AGE (sRAGE) acts as a decoy for capturing circulating AGE, thus preventing them from binding to the cell-surface receptor (RAGE) and protecting against the RAGE-AGE axis-elicited processes. We hypothesized that low sRAGE levels might be associated with increased arterial stiffness. DESIGN AND METHOD: In a cross-sectional design, we analyzed 1077 subjects, aged 25 to 64 years, from the Czech population-based study ("Post-MONICA")...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27641663/the-regulation-of-soluble-receptor-for-ages-contributes-to-carbonyl-stress-in-schizophrenia
#19
Mitsuhiro Miyashita, Takuo Watanabe, Tomoe Ichikawa, Kazuya Toriumi, Yasue Horiuchi, Akiko Kobori, Itaru Kushima, Ryota Hashimoto, Motoyuki Fukumoto, Shinsuke Koike, Hiroshi Ujike, Tadao Arinami, Yoshitaka Tatebayashi, Kiyoto Kasai, Masatoshi Takeda, Norio Ozaki, Yuji Okazaki, Takeo Yoshikawa, Naoji Amano, Shinsuke Washizuka, Hiroshi Yamamoto, Toshio Miyata, Masanari Itokawa, Yasuhiko Yamamoto, Makoto Arai
Our previous study showed that enhanced carbonyl stress is closely related to schizophrenia. The endogenous secretory receptor for advanced glycation end-products (esRAGE) is a splice variant of the AGER gene and is one of the soluble forms of RAGE. esRAGE is considered to be a key molecule for alleviating the burden of carbonyl stress by entrapping advanced glycation end-products (AGEs). In the current study, we conducted genetic association analyses focusing on AGER, in which we compared 212 schizophrenic patients to 214 control subjects...
October 21, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27638909/growth-arrest-specific-2-like-protein-1-expression-is-upregulated-in-podocytes-through-advanced-glycation-end-products
#20
Marita Liebisch, Tzvetanka Bondeva, Sybille Franke, Stephan Hause, Gunter Wolf
BACKGROUND: Growth arrest specific 2-like protein 1 (GAS2L1) protein is a member of the GAS2 family of proteins, known to regulate apoptosis and cellular cytoskeleton reorganization in different cells. Recently we identified that Gas2l1 gene expression in podocytes is influenced by advanced glycation end product-bovine serum albumin(AGE-BSA). METHODS: The study was performed employing cultured podocytes and diabetic (db/db) mice, a model of type 2 diabetes. Akbuminuria as wellas urinary neutrophil gelatinase-associated lipocalin (NGAL) excretion as measured with specific ELISAs...
September 16, 2016: Nephrology, Dialysis, Transplantation
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