keyword
MENU ▼
Read by QxMD icon Read
search

sRAGE

keyword
https://www.readbyqxmd.com/read/29261755/interaction-between-environment-nutrient-derived-metabolites-and-immunity-a-possible-role-in-malaria-susceptibility-resistance-in-fulani-and-dogon-of-mali
#1
Karim Traore, Mahamadou A Thera, Anne-Lise Bienvenu, Charles Arama, Guillaume Bonnot, Adeline Lavoignat, Ogobara K Doumbo, Stephane Picot
The role of some nutrient-derived metabolites on the innate and adaptive immune responses is now established. Global research approach investigating the interplay between environment, lifestyle and the host's immune responses is crucial in the understanding of malaria susceptibility. Advanced Glycation end products (AGE), which are food-derived metabolites result from the link between reducing sugar and amino group of proteins, lipids or nucleic acids. The level of exposure to AGEs varies depending on the type of diet...
2017: PloS One
https://www.readbyqxmd.com/read/29204365/the-age-rage-axis-in-an-arab-population-the-united-arab-emirates-healthy-futures-uaehfs-pilot-study
#2
Claire K Inman, Abdullah Aljunaibi, Hyunwook Koh, Abdishakur Abdulle, Raghib Ali, Abdullah Alnaeemi, Eiman Al Zaabi, Naima Oumeziane, Marina Al Bastaki, Mohammed Al-Houqani, Fatma Al-Maskari, Ayesha Al Dhaheri, Syed M Shah, Laila Abdel Wareth, Wael Al Mahmeed, Habiba Alsafar, Fatme Al Anouti, Ayesha Al Hosani, Muna Haji, Divya Galani, Matthew J O'Connor, Jiyoung Ahn, Tomas Kirchhoff, Scott Sherman, Richard B Hayes, Huilin Li, Ravichandran Ramasamy, Ann Marie Schmidt
Aims: The transformation of the United Arab Emirates (UAE) from a semi-nomadic to a high income society has been accompanied by increasing rates of obesity and Type 2 diabetes mellitus. We examined if the AGE-RAGE (receptor for advanced glycation endproducts) axis is associated with obesity and diabetes mellitus in the pilot phase of the UAE Healthy Futures Study (UAEHFS). Methods: 517 Emirati subjects were enrolled and plasma/serum levels of AGE, carboxy methyl lysine (CML)-AGE, soluble (s)RAGE and endogenous secretory (es)RAGE were measured along with weight, height, waist and hip circumference (WC/HC), blood pressure, HbA1c, Vitamin D levels and routine chemistries...
December 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29197515/fingolimod-anti-inflammatory-and-neuroprotective-effects-modulation-of-rage-axis-in-multiple-sclerosis-patients
#3
Zohara Sternberg, Channa Kolb, Kailash Chadha, Adam Nir, Raphael Nir, Rayan George, Joseph Johnson, Jinhee Yu, David Hojnacki
BACKGROUND: We investigated Fingolimod treatment effects on the RAGE (receptor for advanced glycation endproducts) axis in multiple sclerosis (MS) patients. The primary outcome of the study was whether Fingolimod treatment increases serum levels of the soluble RAGE isoforms, sRAGE and esRAGE - both being considered putative endogenous inhibitors of RAGE signaling. Additional variables were serum levels of RAGE ligands, the high mobility group box (HMGB)1 and pentosidine. METHODS: Serum levels of the study variables were measured by ELISA, and compared between baseline (before Fingolimod treatment) and 6 and 12 months post-drug treatment in 17 relapsing MS patients...
March 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29183090/serum-vitamin-d-status-vitamin-d-receptor-polymorphism-and-glucose-homeostasis-in-healthy-subjects
#4
Otto Mayer, Jitka Seidlerová, Václava Černá, Alena Kučerová, Petra Karnosová, Markéta Hronová, Peter Wohlfahrt, Radka Fuchsová, Jan Filipovský, Renata Cífková, Ondřej Topolčan, Martin Pešta
Low vitamin D status has been frequently associated with impaired glucose metabolism. We examined associations between 25-hydroxyvitamin D (25-OH-D) and several parameters of glucose homeostasis in virtually healthy subjects, and explored possible interaction with vitamin D receptor (VDR) polymorphism. Nondiabetic subjects without chronic medication or any known significant manifest disease were selected from large general-population based population survey. Insulin sensitivity and β cell secretion were calculated by homeostasis model assessment (HOMA) and soluble isoform of receptor for advanced glycation end-products (sRAGE) using commercial ELISA...
November 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29178941/s100a8-a9-and-srage-kinetic-after-polytrauma-an-explorative-observational-study
#5
Philippe Joly, John C Marshall, Philippe A Tessier, Chantal Massé, Nathalie Page, Anne Julie Frenette, François Khazoom, Soazig Le Guillan, Yves Berthiaume, Emmanuel Charbonney
BACKGROUND: Following tissue injury after trauma, the activation of innate immune pathways results in systemic inflammation, organ failure and an increased risk of infections. The objective of this study was to characterize the kinetics of the S100A8/S100A9 complex, a new-recognized alarmin, as well as its soluble receptor sRAGE, over time after trauma as potential early biomarkers of the risk of organ damage. METHODS: We collected comprehensive data from consenting patients admitted to an ICU following severe trauma...
November 25, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29176262/elevated-plasma-levels-of-gas6-are-associated-with-acute-lung-injury-in-patients-with-severe-sepsis
#6
Li-Chun Yeh, Ping-Wun Huang, Kuan-Hsian Hsieh, Chung-Hsuan Wang, Yi-Kai Kao, Tzu-Hsiang Lin, Xiao-Lun Lee
Acute lung injury (ALI) is one of the complications of severe sepsis, causing sudden deaths. However, information regarding predictive factors for the onset of ALI in severe sepsis is limited. Growth arrest-specific gene 6 (Gas6) is secreted by endothelial cells and is important for the activation of endothelium during inflammation. This study aimed to investigate the predictive effect of plasma Gas6 in patients with severe sepsis. Collection of plasma samples was carried out from 129 participants with severe sepsis following with or without ALI development...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29148590/effects-of-bergenin-on-methylglyoxal-induced-damage-in-osteoblastic-mc3t3-e1-cells
#7
Kyung Hee Lee, Eun Mi Choi
Bergenin is the main chemical constituent of plants in the genus Bergenia, which are used in traditional medicines. Methylglyoxal (MG), a highly reactive dicarbonyl compound, is the major precursor for forming advanced glycation end products (AGEs). Pretreating MC3T3-E1 cells with bergenin prevented MG-induced protein adduct formation. Bergenin inhibited the MG-induced soluble receptor for AGE (sRAGE), interleukin, reactive oxygen species and mitochondrial superoxide production. Additionally bergenin increased glyoxalase I activity, glutathione, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 levels in the presence of MG...
November 17, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29147074/increased-levels-of-srage-in-diabetic-ckd-g5d-patients-a-potential-protective-mechanism-against-age-related-upregulation-of-fibroblast-growth-factor-23-and-inflammation
#8
Elena Dozio, Valentina Corradi, Elena Vianello, Elisa Scalzotto, Massimo de Cal, Massimiliano Marco Corsi Romanelli, Claudio Ronco
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29127006/srage-prolonged-stem-cell-survival-and-suppressed-rage-related-inflammatory-cell-and-t-lymphocyte-accumulations-in-an-alzheimer-s-disease-model
#9
Seyeon Oh, Myeongjoo Son, Junwon Choi, Sojung Lee, Kyunghee Byun
The main causes of Alzheimer's disease (AD) have not determined and effective treatment has not been developed yet, even though extensive researches and several clinical trials have been conducted.. Fortunately, stem cell transplantation is emerging as a potential therapeutic candidate for AD, but the success of stem cell based therapy depends on the survival of transplanted cells. Here, we generated sRAGE secreting mesenchymal stem cells (sRAGE-MSCs) and then injected these MSCs or control MSCs with amyloid beta 1-42 (Aβ1-42) into the entorhinal cortices of male Sprague Dawley rats...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29098526/elevated-plasma-level-of-soluble-form-of-rage-in-ischemic-stroke-patients-with-dementia
#10
Sung-Chun Tang, Kai-Chien Yang, Chaur-Jong Hu, Hung-Yi Chiou, Chau Chung Wu, Jiann-Shing Jeng
The receptor for advanced glycation end products (RAGE) and its downstream pathways are involved in various inflammatory and immune responses. Importantly, there is soluble RAGE (sRAGE) that forms either by alternative splicing of RAGE messenger ribonucleic acid as the endogenous soluble form of RAGE (esRAGE) or by proteolytic cleavage of full-length RAGE protein. This study aimed to investigate the associations of the plasma levels of sRAGE and esRAGE in ischemic stroke (IS) patients with and without dementia...
December 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29079726/srage-alleviates-neutrophilic-asthma-by-blocking-hmgb1-rage-signalling-in-airway-dendritic-cells
#11
Fang Zhang, Xin Su, Gang Huang, Xiao-Feng Xin, E-Hong Cao, Yi Shi, Yong Song
Receptor for advanced glycation end products (RAGE) plays a role in inflammatory reactions. The soluble form of RAGE (sRAGE) acts as a decoy to inhibit interactions of RAGE with advanced glycation end products such as High mobility group box 1 (HMGB1). We have demonstrated that HMGB1 directs Th17 skewing by regulating dendritic cell (DC) functions in a previous study. However, the protective effects of HMGB1 blockade with sRAGE in the development of neutrophilic asthma remain unclear. Here, we showed that allergen challenge decreased expression of sRAGE in a murine model of neutrophilic asthma, correlating well with neutrophil counts and interleukin (IL)-17 production...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040215/role-of-receptor-for-advanced-glycation-end-products-in-regulating-lung-fluid-balance-in-lipopolysaccharide-induced-acute-lung-injury-and-infection-related-acute-respiratory-distress-syndrome
#12
Hao Wang, Tao Wang, Zhicheng Yuan, Yufang Cao, Yongfang Zhou, Junyun He, Yongchun Shen, Ni Zeng, Luqi Dai, Fuqiang Wen, Lei Chen
Receptor for advanced glycation end products (RAGE) is implicated in inflammatory responses in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), but its role in pulmonary edema formation remains unclear, especially in infection-related ARDS mainly caused by pneumonia or sepsis. In this study, we investigated the role of RAGE in alveolar fluid regulation by using RAGE gene knockout (RAGE) mice in a murine ALI model induced by lipopolysaccharide (LPS), and by comparing soluble RAGE (sRAGE) levels in serum and bronchial alveolar lavage fluid (BALF) between ARDS patients and control subjects...
October 16, 2017: Shock
https://www.readbyqxmd.com/read/28974473/fasting-blood-soluble-rage-may-be-causally-implicated-in-impaired-glucose-metabolism-in-chinese-patients-with-primary-hypertension
#13
Yuge Wang, Wei Zhang, Hongye Zhao, Yuefei Wang, Changzhu Lu, Xue Li, Yang Wang, Yu Xiao, Yanli Wang, Bin Wang
We prepared to investigate the association of four well-defined polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with the changes of fasting blood soluble RAGE (sRAGE) and endogenous secretory RAGE (esRAGE) and the risk for impaired glucose metabolism (IGM) in 1704 patients with primary hypertension, aiming to infer possible causality between sRAGE/esRAGE and IGM. This was a hospital-based case-control study, including 848 patients coexisting with IGM (the case group) and 856 patients with normal glucose tolerance (the control group)...
September 30, 2017: Gene
https://www.readbyqxmd.com/read/28973588/hba1c-identifies-subjects-with-prediabetes-and-subclinical-left-ventricular-diastolic-dysfunction
#14
Antonino Di Pino, Sarah Mangiafico, Francesca Urbano, Roberto Scicali, Salvatore Scandura, Veronica D'Agate, Salvatore Piro, Corrado Tamburino, Francesco Purrello, Agata Maria Rabuazzo
Context: Prediabetes is associated with subclinical cardiac changes associated with heart failure development. Objective: We investigated diastolic function and its association with markers of glycation and inflammation related to cardiovascular disease in patients with prediabetes. We focused on individuals with prediabetes identified only by glycated hemoglobin A1c [HbA1c; 5.7% to 6.4% and normal fasting glucose (NFG) and normal glucose tolerance (NGT) after an oral glucose tolerance test (OGTT)]...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28947744/therapeutic-effectiveness-of-anti-rage-antibody-administration-in-a-rat-model-of-crush-injury
#15
Hisatake Matsumoto, Naoya Matsumoto, Junya Shimazaki, Junichiro Nakagawa, Yukio Imamura, Kazuma Yamakawa, Tomoki Yamada, Mitsunori Ikeda, Hiroko Hiraike, Hiroshi Ogura, Takeshi Shimazu
Crush injury patients often have systemic inflammatory response syndrome that leads to multiple organ failure. Receptor for advanced glycation endproducts (RAGE) functions as a pattern recognition receptor that regulates inflammation. We evaluated the effects of anti-RAGE antibody in a crush injury model. Pressure was applied to both hindlimbs of rats for 6 h by 3.0-kg blocks and then released. Animals were randomly divided into the sham (RAGE-Sh) group, crush (RAGE-Ctrl) group or anti-RAGE antibody-treated crush (RAGE-Tx) group...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28941024/serum-levels-of-hmgb1-and-srage-are-associated-to-extraglandular-involvement-and-disease-activity-as-defined-by-essdai-in-sj%C3%A3-gren-s-syndrome
#16
Anna-Maria Kanne, Maike Jülich, Amira Mahmutovic, Isabella Tröster, Bettina Sehnert, Vilma Urbonaviciute, Reinhard E Voll, Florian Kollert
OBJECTIVE: To assess serum levels of high mobility group box 1 (HMGB1) and the soluble receptor for advanced glycation endproducts (sRAGE) in patients with Sjögren's Syndrome (SS) and explore correlations with disease activity. METHODS: Thirty-nine patients with SS and 21 healthy controls (HC) were included in this cross-sectional study. Clinical and laboratory values were obtained from all patients. Disease activity was assessed by European League against Rheumatism (EULAR) SS disease activity index (ESSDAI)...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28938337/pulse-pressure-is-associated-with-plasma-amyloid-%C3%AE-transport-dysfunction
#17
Yu Jiang, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang, Qiumin Qu
OBJECTIVE: Increased pulse pressure (PP) has been implicated in the development and progression of Alzheimer's disease in middle-aged and elderly adults. Considering the close relationship between peripheral amyloid-β clearance and brain amyloid-β deposition, we investigated the potential association between PP and plasma amyloid-β transport function. METHODS: In this cross-sectional study, a total of 1118 participants underwent a health assessment and quantification of plasma amyloid-β and amyloid-β transporter expression...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28926869/purification-and-characterization-of-the-soluble-form-of-the-receptor-for-advanced-glycation-end-products-srage-a-novel-fast-economical-and-convenient-method
#18
Varun Kumar, Alba Sulaj, Thomas Fleming, Peter P Nawroth
The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor which belongs to the pattern recognition receptor family and can bind to various ligands such as advanced glycation end-products (AGEs), members of the S100 protein family, glycosaminoglycans, amyloid β peptides, high-mobility group box-1 (HMGB1) and nucleic acids through its extracellular domain. The RAGE-ligand interaction leads to the activation of MAP kinase and NF-kB signaling pathways. Further ligand-induced up-regulation of RAGE is involved in various patho-physiological situations including late diabetic complications, Alzheimer disease and several other neurodegenerative diseases...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926576/receptor-for-advanced-glycation-end-products-and-world-trade-center-particulate-induced-lung-function-loss-a-case-cohort-study-and-murine-model-of-acute-particulate-exposure
#19
Erin J Caraher, Sophia Kwon, Syed H Haider, George Crowley, Audrey Lee, Minah Ebrahim, Liqun Zhang, Lung-Chi Chen, Terry Gordon, Mengling Liu, David J Prezant, Ann Marie Schmidt, Anna Nolan
World Trade Center-particulate matter(WTC-PM) exposure and metabolic-risk are associated with WTC-Lung Injury(WTC-LI). The receptor for advanced glycation end-products (RAGE) is most highly expressed in the lung, mediates metabolic risk, and single-nucleotide polymorphisms at the AGER-locus predict forced expiratory volume(FEV). Our objectives were to test the hypotheses that RAGE is a biomarker of WTC-LI in the FDNY-cohort and that loss of RAGE in a murine model would protect against acute PM-induced lung disease...
2017: PloS One
https://www.readbyqxmd.com/read/28923371/can-soluble-receptor-for-advanced-glycation-end-product-srage-levels-in-blood-be-used-as-a-predictor-of-cardiovascular-diseases
#20
EDITORIAL
Naoto Katakami
No abstract text is available yet for this article.
November 2017: Atherosclerosis
keyword
keyword
9865
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"