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https://www.readbyqxmd.com/read/29148590/effects-of-bergenin-on-methylglyoxal-induced-damage-in-osteoblastic-mc3t3-e1-cells
#1
Kyung Hee Lee, Eun Mi Choi
Bergenin is the main chemical constituent of plants in the genus Bergenia, which are used in traditional medicines. Methylglyoxal (MG), a highly reactive dicarbonyl compound, is the major precursor for forming advanced glycation end products (AGEs). Pretreating MC3T3-E1 cells with bergenin prevented MG-induced protein adduct formation. Bergenin inhibited the MG-induced soluble receptor for AGE (sRAGE), interleukin, reactive oxygen species and mitochondrial superoxide production. Additionally bergenin increased glyoxalase I activity, glutathione, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 levels in the presence of MG...
November 17, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29147074/increased-levels-of-srage-in-diabetic-ckd-g5d-patients-a-potential-protective-mechanism-against-age-related-upregulation-of-fibroblast-growth-factor-23-and-inflammation
#2
Elena Dozio, Valentina Corradi, Elena Vianello, Elisa Scalzotto, Massimo de Cal, Massimiliano Marco Corsi Romanelli, Claudio Ronco
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29127006/srage-prolonged-stem-cell-survival-and-suppressed-rage-related-inflammatory-cell-and-t-lymphocyte-accumulations-in-an-alzheimer-s-disease-model
#3
Seyeon Oh, Myeongjoo Son, Junwon Choi, Sojung Lee, Kyunghee Byun
The main causes of Alzheimer's disease (AD) have not determined despite extensive researches and many clinical trials, and as yet, no effective treatment has been developed. Fortunately, stem cell transplantation is emerging as potential therapeutic candidate for AD, but the success of stem cell based therapy depends on the survival of transplanted cells. Here, we generated sRAGE secreting mesenchymal stem cells (sRAGE-MSCs) and then injected theses MSCs or control MSCs with amyloid beta 1-42 (Aβ1-42) into the entorhinal cortices of male Sprague Dawley rats...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29098526/elevated-plasma-level-of-soluble-form-of-rage-in-ischemic-stroke-patients-with-dementia
#4
Sung-Chun Tang, Kai-Chien Yang, Chaur-Jong Hu, Hung-Yi Chiou, Chau Chung Wu, Jiann-Shing Jeng
The receptor for advanced glycation end products (RAGE) and its downstream pathways are involved in various inflammatory and immune responses. Importantly, there is soluble RAGE (sRAGE) that forms either by alternative splicing of RAGE messenger ribonucleic acid as the endogenous soluble form of RAGE (esRAGE) or by proteolytic cleavage of full-length RAGE protein. This study aimed to investigate the associations of the plasma levels of sRAGE and esRAGE in ischemic stroke (IS) patients with and without dementia...
November 2, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29079726/srage-alleviates-neutrophilic-asthma-by-blocking-hmgb1-rage-signalling-in-airway-dendritic-cells
#5
Fang Zhang, Xin Su, Gang Huang, Xiao-Feng Xin, E-Hong Cao, Yi Shi, Yong Song
Receptor for advanced glycation end products (RAGE) plays a role in inflammatory reactions. The soluble form of RAGE (sRAGE) acts as a decoy to inhibit interactions of RAGE with advanced glycation end products such as High mobility group box 1 (HMGB1). We have demonstrated that HMGB1 directs Th17 skewing by regulating dendritic cell (DC) functions in a previous study. However, the protective effects of HMGB1 blockade with sRAGE in the development of neutrophilic asthma remain unclear. Here, we showed that allergen challenge decreased expression of sRAGE in a murine model of neutrophilic asthma, correlating well with neutrophil counts and interleukin (IL)-17 production...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040215/role-of-receptor-for-advanced-glycation-end-products-in-regulating-lung-fluid-balance-in-lipopolysaccharide-induced-acute-lung-injury-and-infection-related-acute-respiratory-distress-syndrome
#6
Hao Wang, Tao Wang, Zhicheng Yuan, Yufang Cao, Yongfang Zhou, Junyun He, Yongchun Shen, Ni Zeng, Luqi Dai, Fuqiang Wen, Lei Chen
Receptor for advanced glycation end products (RAGE) is implicated in inflammatory responses in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), but its role in pulmonary edema formation remains unclear, especially in infection-related ARDS mainly caused by pneumonia or sepsis. In this study, we investigated the role of RAGE in alveolar fluid regulation by using RAGE gene knockout (RAGE) mice in a murine ALI model induced by lipopolysaccharide (LPS), and by comparing soluble RAGE (sRAGE) levels in serum and bronchial alveolar lavage fluid (BALF) between ARDS patients and control subjects...
October 16, 2017: Shock
https://www.readbyqxmd.com/read/28974473/fasting-blood-soluble-rage-may-be-causally-implicated-in-impaired-glucose-metabolism-in-chinese-patients-with-primary-hypertension
#7
Yuge Wang, Wei Zhang, Hongye Zhao, Yuefei Wang, Changzhu Lu, Xue Li, Yang Wang, Yu Xiao, Yanli Wang, Bin Wang
We prepared to investigate the association of four well-defined polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with the changes of fasting blood soluble RAGE (sRAGE) and endogenous secretory RAGE (esRAGE) and the risk for impaired glucose metabolism (IGM) in 1704 patients with primary hypertension, aiming to infer possible causality between sRAGE/esRAGE and IGM. This was a hospital-based case-control study, including 848 patients coexisting with IGM (the case group) and 856 patients with normal glucose tolerance (the control group)...
September 30, 2017: Gene
https://www.readbyqxmd.com/read/28973588/hba1c-identifies-subjects-with-prediabetes-and-subclinical-left-ventricular-diastolic-dysfunction
#8
Antonino Di Pino, Sarah Mangiafico, Francesca Urbano, Roberto Scicali, Salvatore Scandura, Veronica D'Agate, Salvatore Piro, Corrado Tamburino, Francesco Purrello, Agata Maria Rabuazzo
Context: Prediabetes is associated with subclinical cardiac changes associated with heart failure development. Objective: We investigated diastolic function and its association with markers of glycation and inflammation related to cardiovascular disease in patients with prediabetes. We focused on individuals with prediabetes identified only by glycated hemoglobin A1c [HbA1c; 5.7% to 6.4% and normal fasting glucose (NFG) and normal glucose tolerance (NGT) after an oral glucose tolerance test (OGTT)]...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28947744/therapeutic-effectiveness-of-anti-rage-antibody-administration-in-a-rat-model-of-crush-injury
#9
Hisatake Matsumoto, Naoya Matsumoto, Junya Shimazaki, Junichiro Nakagawa, Yukio Imamura, Kazuma Yamakawa, Tomoki Yamada, Mitsunori Ikeda, Hiroko Hiraike, Hiroshi Ogura, Takeshi Shimazu
Crush injury patients often have systemic inflammatory response syndrome that leads to multiple organ failure. Receptor for advanced glycation endproducts (RAGE) functions as a pattern recognition receptor that regulates inflammation. We evaluated the effects of anti-RAGE antibody in a crush injury model. Pressure was applied to both hindlimbs of rats for 6 h by 3.0-kg blocks and then released. Animals were randomly divided into the sham (RAGE-Sh) group, crush (RAGE-Ctrl) group or anti-RAGE antibody-treated crush (RAGE-Tx) group...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28941024/serum-levels-of-hmgb1-and-srage-are-associated-to-extraglandular-involvement-and-disease-activity-as-defined-by-essdai-in-sj%C3%A3-gren-s-syndrome
#10
Anna-Maria Kanne, Maike Jülich, Amira Mahmutovic, Isabella Tröster, Bettina Sehnert, Vilma Urbonaviciute, Reinhard E Voll, Florian Kollert
OBJECTIVE: To assess serum levels of high mobility group box 1 (HMGB1) and the soluble receptor for advanced glycation endproducts (sRAGE) in patients with Sjögren's Syndrome (SS) and explore correlations with disease activity. METHODS: Thirty-nine patients with SS and 21 healthy controls (HC) were included in this cross-sectional study. Clinical and laboratory values were obtained from all patients. Disease activity was assessed by European League against Rheumatism (EULAR) SS disease activity index (ESSDAI)...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28938337/pulse-pressure-is-associated-with-plasma-amyloid-%C3%AE-transport-dysfunction
#11
Yu Jiang, Suhang Shang, Pei Li, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang, Qiumin Qu
OBJECTIVE: Increased pulse pressure (PP) has been implicated in the development and progression of Alzheimer's disease in middle-aged and elderly adults. Considering the close relationship between peripheral amyloid-β clearance and brain amyloid-β deposition, we investigated the potential association between PP and plasma amyloid-β transport function. METHODS: In this cross-sectional study, a total of 1118 participants underwent a health assessment and quantification of plasma amyloid-β and amyloid-β transporter expression...
September 21, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28926869/purification-and-characterization-of-the-soluble-form-of-the-receptor-for-advanced-glycation-end-products-srage-a-novel-fast-economical-and-convenient-method
#12
Varun Kumar, Alba Sulaj, Thomas Fleming, Peter P Nawroth
The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor which belongs to the pattern recognition receptor family and can bind to various ligands such as advanced glycation end-products (AGEs), members of the S100 protein family, glycosaminoglycans, amyloid β peptides, high-mobility group box-1 (HMGB1) and nucleic acids through its extracellular domain. The RAGE-ligand interaction leads to the activation of MAP kinase and NF-kB signaling pathways. Further ligand-induced up-regulation of RAGE is involved in various patho-physiological situations including late diabetic complications, Alzheimer disease and several other neurodegenerative diseases...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926576/receptor-for-advanced-glycation-end-products-and-world-trade-center-particulate-induced-lung-function-loss-a-case-cohort-study-and-murine-model-of-acute-particulate-exposure
#13
Erin J Caraher, Sophia Kwon, Syed H Haider, George Crowley, Audrey Lee, Minah Ebrahim, Liqun Zhang, Lung-Chi Chen, Terry Gordon, Mengling Liu, David J Prezant, Ann Marie Schmidt, Anna Nolan
World Trade Center-particulate matter(WTC-PM) exposure and metabolic-risk are associated with WTC-Lung Injury(WTC-LI). The receptor for advanced glycation end-products (RAGE) is most highly expressed in the lung, mediates metabolic risk, and single-nucleotide polymorphisms at the AGER-locus predict forced expiratory volume(FEV). Our objectives were to test the hypotheses that RAGE is a biomarker of WTC-LI in the FDNY-cohort and that loss of RAGE in a murine model would protect against acute PM-induced lung disease...
2017: PloS One
https://www.readbyqxmd.com/read/28923371/can-soluble-receptor-for-advanced-glycation-end-product-srage-levels-in-blood-be-used-as-a-predictor-of-cardiovascular-diseases
#14
EDITORIAL
Naoto Katakami
No abstract text is available yet for this article.
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28915840/evolution-and-bad-prognostic-value-of-advanced-glycation-end-products-after-acute-heart-failure-relation-with-body-composition
#15
Beatriz Paradela-Dobarro, Ángel Fernández-Trasancos, Diana Bou-Teen, Sonia Eiras, Rocío González-Ferreiro, Rosa M Agra, Alfonso Varela-Román, Ana I Castro-Pais, Marcos C Carreira, Felipe F Casanueva, Ezequiel Álvarez, José R González-Juanatey
AIM: The role of advanced glycation end products (AGEs) and their soluble receptor (sRAGE) on the progression and prognosis of acute heart failure (HF) was analysed in relation with metabolic parameters as body composition and nutritional status. METHODS: A hundred and fifty consecutive patients were included in a prospective clinical study during hospitalization by acute HF. Detailed medical history, physical examination, electrocardiogram, echocardiogram and vein peripheral blood were taken for all patients...
September 15, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28912521/advanced-glycation-end-product-age-albumin-from-activated-macrophage-is-critical-in-human-mesenchymal-stem-cells-survival-and-post-ischemic-reperfusion-injury
#16
Myeongjoo Son, Woong Chol Kang, Seyeon Oh, Delger Bayarsaikhan, Hyosang Ahn, Jaesuk Lee, Hyunjin Park, Sojung Lee, Junwon Choi, Hye Sun Lee, Phillip C Yang, Kyunghee Byun, Bonghee Lee
Post-ischemic reperfusion injury (PIRI) triggers an intense inflammatory response which is essential for repair but is also implicated in pathogenesis of post-ischemic remodeling in several organs in human. Stem cell therapy has recently emerged as a promising method for treatment of PIRI in human. However, satisfactory results have not been reported due to severe loss of injected stem cells in PIRI including critical limb ischemia (CLI). For investigating the advanced glycation end-product-albumin (AGE-albumin) from activated macrophages is critical in both muscle cell and stem cell death, we evaluated the recovery of PIRI-CLI by injection of human bone marrow derived mesenchymal stem cells (hBD-MSCs) with or without soluble receptor for AGEs (sRAGE)...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900377/serum-soluble-receptor-of-advanced-glycation-end-products-and-risk-of-metabolic-syndrome-in-egyptian-obese-women
#17
Moushira Zaki, Sanaa Kamal, Shams Kholousi, Hala T El-Bassyouni, Walaa Yousef, Hanaa Reyad, Ramy Mohamed, Walaa A Basha
Obesity is one of the diagnostic criteria of metabolic syndrome (MS). It is correlated with insulin resistance (IR) and high vascular risk as well. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in abnormal metabolic components in obese women. This study aimed to explore the serum levels of sRAGE in Egyptian obese women and compare with healthy non-obese controls and investigate the relationship between serum sRAGE, metabolic parameters, and obesity complications. The soluble form of receptor for advanced glycation end products (sRAGE), anthropometry, metabolic and biochemical biomarkers were measured in 100 obese women and 100 age-matched healthy control non-obese women...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28864204/soluble-form-of-receptor-for-advanced-glycation-end-products-and-incidence-of-new-cardiovascular-events-among-patients-with-cardiovascular-disease
#18
Stefan Reichert, Ulrike Triebert, Alexander Navarrete Santos, Britt Hofmann, Hans-Günter Schaller, Axel Schlitt, Susanne Schulz
BACKGROUND AND AIMS: Soluble RAGE (sRAGE) serum level could be a biomarker for atherosclerosis and subsequent diseases such as cardiovascular disease (CVD). Therefore, we wanted to investigate whether peripheral sRAGE level is associated with new cardiovascular events among patients with CVD using the Cox's regression analysis. METHODS: In this three-year longitudinal cohort study, 1002 in-patients with angiographically proven CVD were included. In 933 patients, sRAGE levels were determined by a commercial available ELISA kit at the time of baseline examination...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28811295/circulating-soluble-rage-isoforms-are-attenuated-in-obese-impaired-glucose-tolerant-individuals-and-are-associated-with-the-development-of-type-2-diabetes
#19
Edwin R Miranda, Vikram S Somal, Jacob T Mey, Brian K Blackburn, Edward Wang, Sarah S Farabi, Kristian Karstoft, Ciaran E Fealy, Sangeeta R Kashyap, John P Kirwan, Laurie Quinn, Thomas P J Solomon, Jacob M Haus
The soluble receptor for advanced glycation endproducts (sRAGE) may be protective against inflammation associated with obesity and type 2 diabetes (T2DM). The aim of this study was to determine the distribution of sRAGE isoforms, and whether sRAGE isoforms are associated with risk of T2DM development in subjects spanning the glucose tolerance continuum. In this retrospective analysis, circulating total sRAGE and endogenous secretory RAGE (esRAGE) were quantified via ELISA and cleaved RAGE (cRAGE) was calculated in 274 individuals stratified by glucose tolerance status (GTS) and obesity...
August 15, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28775380/rage-inhibition-reduces-acute-lung-injury-in-mice
#20
Raiko Blondonnet, Jules Audard, Corinne Belville, Gael Clairefond, Jean Lutz, Damien Bouvier, Laurence Roszyk, Christelle Gross, Marilyne Lavergne, Marianne Fournet, Loic Blanchon, Caroline Vachias, Christelle Damon-Soubeyrand, Vincent Sapin, Jean-Michel Constantin, Matthieu Jabaudon
The receptor for advanced glycation end-products (RAGE) is involved in inflammatory response during acute respiratory distress syndrome (ARDS). Growing body of evidence support strategies of RAGE inhibition in experimental lung injury, but its modalities and effects remain underinvestigated. Anesthetised C57BL/6JRj mice were divided in four groups; three of them underwent orotracheal instillation of acid and were treated with anti-RAGE monoclonal antibody (mAb) or recombinant soluble RAGE (sRAGE), acting as a decoy receptor...
August 3, 2017: Scientific Reports
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