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https://www.readbyqxmd.com/read/28811295/circulating-soluble-rage-isoforms-are-attenuated-in-obese-impaired-glucose-tolerant-individuals-and-are-associated-with-the-development-of-type-2-diabetes
#1
Edwin R Miranda, Vikram S Somal, Jacob T Mey, Brian K Blackburn, Edward Wang, Sarah S Farabi, Kristian Karstoft, Ciaran E Fealy, Sangeeta R Kashyap, John P Kirwan, Laurie Quinn, Thomas P J Solomon, Jacob M Haus
The soluble receptor for advanced glycation endproducts (sRAGE) may be protective against inflammation associated with obesity and type 2 diabetes (T2DM). The aim of this study was to determine the distribution of sRAGE isoforms, and whether sRAGE isoforms are associated with risk of T2DM development in subjects spanning the glucose tolerance continuum. In this retrospective analysis, circulating total sRAGE and endogenous secretory RAGE (esRAGE) were quantified via ELISA and cleaved RAGE (cRAGE) was calculated in 274 individuals stratified by glucose tolerance status (GTS) and obesity...
August 15, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28775380/rage-inhibition-reduces-acute-lung-injury-in-mice
#2
Raiko Blondonnet, Jules Audard, Corinne Belville, Gael Clairefond, Jean Lutz, Damien Bouvier, Laurence Roszyk, Christelle Gross, Marilyne Lavergne, Marianne Fournet, Loic Blanchon, Caroline Vachias, Christelle Damon-Soubeyrand, Vincent Sapin, Jean-Michel Constantin, Matthieu Jabaudon
The receptor for advanced glycation end-products (RAGE) is involved in inflammatory response during acute respiratory distress syndrome (ARDS). Growing body of evidence support strategies of RAGE inhibition in experimental lung injury, but its modalities and effects remain underinvestigated. Anesthetised C57BL/6JRj mice were divided in four groups; three of them underwent orotracheal instillation of acid and were treated with anti-RAGE monoclonal antibody (mAb) or recombinant soluble RAGE (sRAGE), acting as a decoy receptor...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763872/-research-of-the-biomarkers-in-pulmonary-and-extrapulmonary-acute-respiratory-distress-syndrome
#3
Q Yang, Z Q Li, H B Lan, S S Xiong, S S Wang, C S Yan
Objective: To explore the biomarkers that applied to pulmonary acute respiratory distress syndrome (ARDS) and extrapulmonary ARDS respectively. Methods: A total of 49 eligible patients with ARDS were selected from Department of Respiratory intensive care unite (ICU) , Department of General ICU and Department of Emergency ICU, the Second Affiliated Hospital of Nanchang University, during April 2015 and February 2016, and divided into pulmonary ARDS group (n=26) and extrapulmonary ARDS group (n=23) according to primary causes...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28760504/protection-against-rage-mediated-neuronal-cell-death-by-srage-secreting-human-mesenchymal-stem-cells-in-5xfad-transgenic-mouse-model
#4
Myeongjoo Son, Seyeon Oh, Hyunjin Park, Hyosang Ahn, Junwon Choi, Hyungho Kim, Hye Sun Lee, Sojung Lee, Hye-Jeong Park, Seung U Kim, Bonghee Lee, Kyunghee Byun
Alzheimer's disease (AD), which is the most commonly encountered neurodegenerative disease, causes synaptic dysfunction and neuronal loss due to various pathological processes that include tau abnormality and amyloid beta (Aβ) accumulation. Aβ stimulates the secretion and the synthesis of Receptor for Advanced Glycation End products (RAGE) ligand by activating microglial cells, and has been reported to cause neuronal cell death in amyloid beta1-42 treated rats and in mice with neurotoxin-induced Parkinson's disease...
July 28, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28759844/circulating-soluble-receptor-for-advanced-glycation-end-product-cross-sectional-associations-with-cardiac-markers-and-subclinical-vascular-disease-in-older-men-with-and-without-diabetes
#5
S Goya Wannamethee, Paul Welsh, Olia Papacosta, Elizabeth A Ellins, Julian P J Halcox, Peter H Whincup, Naveed Sattar
BACKGROUND AND AIMS: The soluble receptor for advanced glycation end products (sRAGE) has been implicated in diabetic vascular complications. We have examined the association between sRAGE and cardiac markers [NT-proBNP and cardiac troponin T (cTnT)] and subclinical vascular markers in older men with and without diabetes. METHODS: We performed a cross-sectional study of 1159 men aged 71-92 years with no history of cardiovascular disease (myocardial infarction, stroke, heart failure, coronary artery bypass graft operation or angioplasty)...
July 12, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28744116/tumor-necrosis-factor-receptor-2-as-a-possible-marker-of-copd-in-smokers-and-ex-smokers
#6
Laura Miranda de Oliveira Caram, R Ferrari, D L Nogueira, Mrm Oliveira, F V Francisqueti, S E Tanni, C R Corrêa, I Godoy
INTRODUCTION: Oxidative stress and systemic inflammation are higher in smokers and patients with COPD; however, markers that may help differentiate between smokers and patients with COPD have not yet been identified. We hypothesized that tumor necrosis factor-alpha receptor (TNFR) and soluble form of the receptor for advanced glycation end products (sRAGE) can be indicators of COPD in asymptomatic patients. PATIENTS AND METHODS: We evaluated 32 smokers (smoking history >10 pack-years), 32 patients with mild/moderate COPD (smokers and ex-smokers), and 32 never smokers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28722189/adam10-modulates-calcitriol-regulated-rage-in-cardiomyocytes
#7
Ting-Wei Lee, Yu-Hsun Kao, Ting-I Lee, Yi-Jen Chen
BACKGROUND: Receptor for advanced glycation end products (RAGE) signalling plays a critical role in the pathogenesis of cardiovascular disease. Calcitriol modulates cardiac RAGE expression. This study explored the mechanisms underlying the effect of calcitriol on RAGE and soluble RAGE (sRAGE) expression in cardiomyocytes. MATERIALS AND METHODS: Western blot, ELISA, fluorometric assay and PCR analyses were used to evaluate the RAGE, sRAGE, endogenous secretory RAGE (esRAGE), Jun N-terminal kinase (JNK), and a disintegrin and metalloprotease 10 (ADAM10) expression and enzyme activity in HL-1 atrial myocytes without and with calcitriol (10 and 100 nM), nuclear factor-κB (NF-κB) inhibitor (50 μg/mL), or ADAM10 inhibitor (5 μM) incubation for 48 h...
July 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28713911/glucagon-like-peptide-1-analogue-liraglutide-ameliorates-atherogenesis-via-inhibiting-advanced-glycation-end-product-induced-receptor-for-advanced-glycosylation-end-product-expression-in-apolipoprotein-e-deficient-mice
#8
Peicheng Li, Zhaosheng Tang, Lin Wang, Bo Feng
Glucagon-like peptide-1 (GLP-1) can protect arteriosclerotic lesions in apolipoprotein-E deficient (ApoE-/-) mice. Advanced glycation end products (AGEs)/receptor for advanced glycation end products (RAGE) interaction serves a key role in the development of diabetic vascular complications. The present study examined whether the GLP-1 analogue liraglutide can ameliorate atherogenesis via inhibiting AGEs-induced RAGE expression. Male ApoE-/- mice (age, 10 weeks) were divided into control, GLP-1, AGEs and AGEs+GLP-1 group...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28712719/ages-rages-and-s-rage-friend-or-foe-for-cancer
#9
REVIEW
Saheem Ahmad, Hamda Khan, Zeba Siddiqui, Mohd Yasir Khan, Shahnawaz Rehman, Uzma Shahab, Tatyana Godovikova, Vladimir Silnikov, Moinuddin
Impaired awareness of glycation biology in cancer initiation and progression is one of the fundamental reasons for its meticulous investigation of the molecules involved in signalling pathway. Glycation of biological macromolecules results in the progression of advanced glycation end-products (AGEs) that proliferates the process of carcinogenesis by activation of transcription factors and release of cytokines. The receptor for advanced glycation end-products (RAGEs) with the binding of its different ligands like; AGEs, HMGB1 and S100 activate the signalling arrays...
July 13, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28695773/polymorphisms-of-the-receptor-for-advanced-glycation-end-products-and-glyoxalase-i-and-long-term-outcome-in-patients-with-breast-cancer
#10
Petra Tesarova, Tomas Zima, Ales A Kubena, Marta Kalousova
Receptor for advanced glycation end products and glyoxalase I metabolizing advanced glycation end product precursors may play important role in the pathogenesis and progression of cancer. Potential relation between soluble forms of receptor for advanced glycation end products (sRAGE), receptor for advanced glycation end products, glyoxalase I polymorphisms, and long-term outcome (median follow-up of 10.3 years) was studied in 116 patients with breast cancer. Gly82Ser and 2184 A/G RAGE polymorphisms were related to the mortality due to the breast cancer and -419 A/C glyoxalase I polymorphism was related to the overall mortality of the patients suggesting their role not only in the risk of breast cancer but also in the outcome of patients with breast cancer...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28630869/increase-of-soluble-rage-in-cerebrospinal-fluid-following-subarachnoid-haemorrhage
#11
Bartosz Sokół, Norbert Wąsik, Roman Jankowski, Marcin Hołysz, Witold Mańko, Robert Juszkat, Tomasz Małkiewicz, Paweł P Jagodziński
Receptors for advanced glycation end-products (RAGE) mediate the inflammatory reaction that follows aneurysmal subarachnoid haemorrhage. Soluble RAGE (sRAGE) may function as a decoy receptor. The significance of this endogenous anti-inflammatory mechanism in subarachnoid haemorrhage (SAH) remains unknown. The present study aims to analyse sRAGE levels in the cerebrospinal fluid (CSF) of SAH patients. sRAGE levels were assayed by ELISA kit in 47 CSF samples collected on post-SAH days 0-3, 5-7, and 10-14 from 27 SAH patients with acute hydrocephalus...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28630637/evaluation-of-circulating-srage-in-osteoporosis-according-to-bmi-adipokines-and-fracture-risk-a-pilot-observational-study
#12
Emanuela Galliera, Monica Gioia Marazzi, Carmine Gazzaruso, Pietro Gallotti, Adriana Coppola, Tiziana Montalcini, Arturo Pujia, Massimiliano M Corsi Romanelli
BACKGROUND: Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28610627/multiple-biomarkers-predict-disease-severity-progression-and-mortality-in-copd
#13
Rachel L Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E Miller, Ruth Tal-Singer, Russell P Bowler
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease characterized by multiple subtypes and variable disease progression. Blood biomarkers have been variably associated with subtype, severity, and disease progression. Just as combined clinical variables are more highly predictive of outcomes than individual clinical variables, we hypothesized that multiple biomarkers may be more informative than individual biomarkers to predict subtypes, disease severity, disease progression, and mortality...
June 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28608784/suppressed-mmp-9-activity-in-myocardial-infarction-related-cardiogenic-shock-implies-diminished-rage-degradation
#14
Simina-Ramona Selejan, Lisa Hewera, Matthias Hohl, Andrey Kazakov, Sebastian Ewen, Ingrid Kindermann, Michael Böhm, Andreas Link
BACKGROUND: Receptor for advanced glycation end products (RAGE) and its cleavage fragment soluble RAGE (sRAGE) are opposite players in inflammation. Enhanced monocytic RAGE expression and decreased plasma sRAGE levels are associated with higher mortality in infarction-related cardiogenic shock. Active matrix metalloproteinase-9 (MMP-9) has been implied in RAGE ectodomain cleavage and subsequently sRAGE shedding in vitro. We investigated MMP-9 activity in myocardial infarction-induced cardiogenic shock with regard to RAGE/sRAGE regulation...
July 2017: Shock
https://www.readbyqxmd.com/read/28582866/neurodegenerative-markers-are-increased-in-postmortem-ba21-tissue-from-african-americans-with-alzheimer-s-disease
#15
Sherry A Ferguson, John J Panos, Daniel Sloper, Vijayalakshmi Varma
BACKGROUND: Alzheimer's disease (AD) presents with an earlier onset age and increased symptom severity in African Americans and Hispanics. OBJECTIVE: Although the prevalence of plaques and tangles may not exhibit ethnicity-related differences, levels of neurodegenerative proteins have not been described. METHODS: Here, levels of five proteins (i.e., S100B, sRAGE, GDNF, Aβ40, and Aβ42) and the Aβ42/Aβ40 ratio were measured in postmortem samples of the middle temporal gyrus (BA21) from age-matched African Americans and Caucasians with AD (n = 6/gender/ethnicity)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28558055/plasma-levels-of-high-mobility-group-box-1-and-soluble-receptor-for-advanced-glycation-end-products-in-primary-antiphospholipid-antibody-syndrome-patients
#16
Kuo-Tung Tang, Tsu-Yi Hsieh, Ya-Hsuan Chao, Meng-Xian Lin, Yi-Hsing Chen, Der-Yuan Chen, Chi-Chen Lin
INTRODUCTION: Many studies have demonstrated elevated circulating levels of high-mobility group box 1 (HMGB1) and decreased circulating levels of soluble receptor for advanced glycation end products (sRAGE) in patients with autoimmune diseases. In the present study, we investigated plasma levels of both HMGB1 and sRAGE in primary antiphospholipid syndrome (pAPS) patients. METHODS: We prospectively recruited 11 pAPS patients, 17 antiphospholipid antibody (APA)-positive SLE patients without APS manifestations (APA+SLE) and 12 SLE patients with secondary APS (APS+SLE)...
2017: PloS One
https://www.readbyqxmd.com/read/28550659/hyperoxia-provokes-a-time-and-dose-dependent-inflammatory-response-in-mechanically-ventilated-mice-irrespective-of-tidal-volumes
#17
Hendrik J F Helmerhorst, Laura R A Schouten, Gerry T M Wagenaar, Nicole P Juffermans, Joris J T H Roelofs, Marcus J Schultz, Evert de Jonge, David J van Westerloo
BACKGROUND: Mechanical ventilation and hyperoxia have the potential to independently promote lung injury and inflammation. Our purpose was to study both time- and dose-dependent effects of supplemental oxygen in an experimental model of mechanically ventilated mice. METHODS: Healthy male C57Bl/6J mice, aged 9-10 weeks, were intraperitoneally anesthetized and randomly assigned to the mechanically ventilated group or the control group. In total, 100 mice were tracheotomized and mechanically ventilated for either 8 or 12 h after allocation to different settings for the applied fractions of inspired oxygen (FiO2, 30, 50, or 90%) and tidal volumes (7...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28434257/ratio-of-serum-levels-of-ages-to-soluble-rage-is-correlated-with-trimethylamine-n-oxide-in-non-diabetic-subjects
#18
Atsuko Tahara, Nobuhiro Tahara, Sho-Ichi Yamagishi, Akihiro Honda, Sachiyo Igata, Yoshikazu Nitta, Munehisa Bekki, Tomohisa Nakamura, Yoichi Sugiyama, Jiahui Sun, Masayoshi Takeuchi, Makiko Shimizu, Hiroshi Yamazaki, Kei Fukami, Yoshihiro Fukumoto
Trimethylamine (TMA), an intestinal microflora-dependent metabolite formed from phosphatidylcholine- and L-carnitine-rich food, such as red meat, is further converted to trimethylamine-N-oxide (TMAO), which could play a role in cardiometabolic disease. Red meat-derived products are one of the major environmental sources of advanced glycation end products (AGEs) that may also contribute to the pathogenesis of cardiometabolic disorders through the interaction with receptor for AGEs (RAGE). However, the relationship among AGEs, soluble form of RAGE (sRAGE) and TMAO in humans remains unclear...
April 23, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28409494/association-between-metabolically-healthy-central-obesity-in-women-and-levels-of-soluble-receptor-for-advanced-glycation-end-products-soluble-vascular-adhesion-protein-1-and-the-activity-of-semicarbazide-sensitive-amine-oxidase
#19
Ivana Koborová, Radana Gurecká, Melinda Csongová, Katarína Volkovová, Éva Szökő, Tamás Tábi, Katarína Šebeková
AIM: To determine the levels of circulating soluble receptor for advanced glycation end products (sRAGE), as a biomarker of risk of metabolic syndrome and cardiovascular disease development in centrally obese (CO) women considered metabolically healthy (COH) in comparison with those metabolically unhealthy (COU). METHODS: 47 lean healthy, 17 COH (presenting waist-to-height ratio ≥0.5 but not elevated blood pressure, atherogenic lipid profile, and insulin resistance), and 50 COU (CO presenting ≥2 risk factors) women aged 40-45 years were included...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28407046/rage-mediated-extracellular-matrix-proteins-accumulation-exacerbates-hysu-induced-pulmonary-hypertension
#20
Daile Jia, Yuhu He, Qian Zhu, Huan Liu, Caojian Zuo, Guilin Chen, Ying Yu, Ankang Lu
Aims: Extracellular matrix (ECM) proteins accumulation contributes to the progression of pulmonary arterial hypertension (PAH), a rare and fatal cardiovascular condition defined by high pulmonary arterial pressure, whether primary, idiopathic, or secondary to other causes. The receptor for advanced glycation end products (RAGE) is constitutively expressed in the lungs and plays an important role in ECM deposition. Nonetheless, the mechanisms by which RAGE mediates ECM deposition/formation in pulmonary arteries and its roles in PAH progression remain unclear...
May 1, 2017: Cardiovascular Research
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