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Homocysteine and stroke

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https://www.readbyqxmd.com/read/27905385/-a-role-of-genetic-factors-and-related-disorder-of-the-folate-cycle-in-ischemic-stroke
#1
V M Shklovsky, I P Lukashevich, A Yu Remennik, S M Gerasimova, G S Selishchev, D I Malin, V V Valyaeva
AIM: To study a role of MTHFR mutations and their associations with the disturbances of basic parameters of the folate cycle in the development of ischemic stroke (IS). MATERIAL AND METHODS: Fifty-one post-stroke patients, 26 women and 25 men, aged from 29 to 87 years, were included in the study. The control group consisted of 47 healthy people, 23 women and 24 men, aged from 30 to 83 years. MTHFR: rs1801131 and rs1801133 polymorphisms were genotyped. Contents of folate, B12 and homocysteine were measured...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27869211/homocysteine-and-its-relationship-to-asymptomatic-carotid-stenosis-in-a-chinese-community-population
#2
Jiaokun Jia, Anxin Wang, Jing Wang, Jianwei Wu, Xiujuan Yan, Yong Zhou, Shengyun Chen, Xingquan Zhao
Little is known about the association between homocysteine (Hcy) and asymptomatic CAS in the healthy population. The purpose of this study was to investigate the relationship between Hcy levels and asymptomatic CAS in a Chinese community population. The current study included 5393 participants who were age of 40 years or older, and free of stroke, transient ischemic attack, and coronary artery disease. Demographic and clinical variables were investigated, and the presence of CAS was assessed by Color Doppler Ultrasound...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27861706/predicting-risk-of-cognitive-decline-in-very-old-adults-using-three-models-the-framingham-stroke-risk-profile-the-cardiovascular-risk-factors-aging-and-dementia-model-and-oxi-inflammatory-biomarkers
#3
Stephanie L Harrison, Anton J M de Craen, Ngaire Kerse, Ruth Teh, Antoneta Granic, Karen Davies, Keith A Wesnes, Wendy P J den Elzen, Jacobijn Gussekloo, Thomas B L Kirkwood, Louise Robinson, Carol Jagger, Mario Siervo, Blossom C M Stephan
OBJECTIVES: To examine the Framingham Stroke Risk Profile (FSRP); the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score, and oxi-inflammatory load (cumulative risk score of three blood biomarkers-homocysteine, interleukin-6, C-reactive protein) for associations with cognitive decline using three cohort studies of very old adults and to examine whether incorporating these biomarkers with the risk scores can affect the association with cognitive decline. DESIGN: Three longitudinal, population-based cohort studies...
November 14, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27858927/is-folic-acid-supplementation-useful-for-chronic-kidney-disease
#4
Gonzalo A Bravo-Soto, Trinidad Madrid
Patients with chronic kidney disease have higher cardiovascular risk than general population, a fact that has been linked to high homocysteine levels. Folic acid supplementation can reduce homocysteine levels, which would reduce cardiovascular events. However, there is controversy about the clinical effects of this measure. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified six systematic reviews comprising 13 trials addressing the question of this article. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach...
November 7, 2016: Medwave
https://www.readbyqxmd.com/read/27834686/elevated-homocysteine-concentrations-decrease-the-antihypertensive-effect-of-angiotensin-converting-enzyme-inhibitors-in-hypertensive-patients
#5
Xianhui Qin, Youbao Li, Ningling Sun, Hong Wang, Yan Zhang, Jiguang Wang, Jianping Li, Xin Xu, Min Liang, Jing Nie, Binyan Wang, Xiaoshu Cheng, Nanfang Li, Yingxian Sun, Lianyou Zhao, Xiaobin Wang, Fan Fan Hou, Yong Huo
OBJECTIVE: We aimed to examine whether baseline homocysteine (Hcy) concentrations affect antihypertensive responses to enalapril treatment among previously untreated hypertensive patients (n=10 783) in the CSPPT (China Stroke Primary Prevention Trial). APPROACH AND RESULTS: After a 3-week run-in treatment with a daily dose of 10 mg enalapril, eligible hypertensive patients were randomly assigned to a double-blind daily treatment of a tablet of either enalapril (10 mg) and folic acid (0...
November 10, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27803490/impact-of-homocysteine-level-on-long-term-cardiovascular-outcomes-in-patients-after-coronary-artery-stenting
#6
Jih-Kai Yeh, Chun-Chi Chen, Ming-Jer Hsieh, Ming-Lung Tsai, Chia-Hung Yang, Dong-Yi Chen, Shang-Hung Chang, Chao-Yung Wang, Cheng-Hung Lee, I-Chang Hsieh
AIM: The prognostic value of homocysteine (HCY) in patients with coronary artery diseases (CAD) is still controversial. The objective of this study was to investigate whether elevated HCY level at admission predict long-term outcomes in patients after percutaneous coronary interventions (PCI) with coronary artery stenting. METHODS: From the institutional registry of Cardiovascular Atherosclerosis and Percutaneous TrAnsluminal INterventions (CAPTAIN), we enrolled a total of 1,307 patients with documented CAD undergone PCI with bare metal stents from July 2003 to December 2014...
November 1, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27775787/ptx3-expression-in-the-plasma-of-elderly-aci-patients-and-its-relationship-with-severity-and-prognosis-of-the-disease
#7
L-Z Qin, W Li, Y Huang, F Lu, S-J Li, H-Q Yang, J-W Zhang
OBJECTIVE: This study aims to investigate the expression of pentraxin3 (PTX3) in elderly patients with acute cerebral infarction (ACI) and to analyze the relationship of PTX3 with the severity and prognosis of ACI. PATIENTS AND METHODS: Between June 2014 and August 2015, 96 elderly patients with first-onset of ACI admitted to our institution were enrolled in the present study. Also, 70 healthy elderly subjects were included as controls in this study. Levels of PTX3, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, homocysteine (Hcy), fibrinogen (FIB), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined in all patients both pre-therapeutically and 30 days post-therapeutically...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27773468/homocysteine-concentration-in-coronary-artery-disease-influence-of-three-common-single-nucleotide-polymorphisms
#8
C Bickel, R B Schnabel, E Zengin, E Lubos, H Rupprecht, K Lackner, C Proust, D Tregouet, S Blankenberg, D Westermann, C Sinning
BACKGROUND AND AIMS: Whether single nucleotide polymorphisms (SNPs) of homocysteine metabolism enzymes influence the rate of cardiovascular (CV) events in coronary artery disease (CAD) patients remains controversial. METHODS AND RESULTS: In this analysis, 1126 subjects from the AtheroGene study with CAD and 332 control subjects without known CAD were included. The following SNPs were investigated: methylentetrahydrofolate reductase (MTHFR-C667T), methionin synthetase (MS-D919G), and cystathionin beta synthetase (CBS-I278T)...
September 17, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27772792/the-homocysteine-associated-variant-rs548987-of-slc17a3-confers-susceptibility-to-ischemic-stroke-in-chinese-population
#9
Shouqing Huang, Lianhua Yin, Yihui Xu, Chunyan Zou, Lidian Chen
Ischemic stroke is a common cause of death due to obstructed blood supply of the brain. Despite growing numbers of research, etiology underlying ischemic stroke remains complex and elusive. Elevated plasma homocysteine has been known as a risk factor for ischemic stroke. Recently, a genome-wide association study reported association between rs548987 of SLC17A3 and homocysteine. Given existing relation between homocysteine and ischemic stroke, SLC17A3 was believed to be a promising candidate gene of ischemic stroke...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27709655/elevated-serum-homocysteine-level-as-an-independent-risk-factor-for-erectile-dysfunction-a-prospective-pilot-case-control-study
#10
Z Zhang, Z Xu, Y Dai, Y Chen
Homocysteine is an amino acid that is produced from the metabolic demethylation of dietary methionine. It has gained arising attention for its association with increased risk of myocardial infarction, stroke and venous thromboembolism. Erectile dysfunction (ED), especially for vasculogenic ED, is a vascular disorder of cavernosal vascular bed. In this prospective pilot case-control study, we investigated plasma homocysteine levels in 32 ED patients and 20 healthy control men. Related patients characteristics including age, weight, height, marital status, smoking and drinking status, level of education were collected and analysed as well as penile colour Doppler ultrasound parameters...
October 6, 2016: Andrologia
https://www.readbyqxmd.com/read/27698959/intake-of-antioxidants-and-b-vitamins-is-inversely-associated-with-ischemic-stroke-and-cerebral-atherosclerosis
#11
Hansaem Choe, Ji-Yun Hwang, Jin A Yun, Ji-Myung Kim, Tae-Jin Song, Namsoo Chang, Yong-Jae Kim, Yuri Kim
BACKGROUND/OBJECTIVES: This study was conducted to examine relationships between dietary habits and intakes of antioxidants and B vitamins and the risk of ischemic stroke, and to compare dietary factors according to the presence of cerebral artery atherosclerosis and stroke subtypes. SUBJECTS/METHODS: A total of 147 patients and 144 control subjects were recruited consecutively in the metropolitan area of Seoul, Korea. Sixty participants each in the case and control groups were included in analyses after 1:1 frequency matching...
October 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27629768/elevated-homocysteine-level-related-to-poor-outcome-after-thrombolysis-in-acute-ischemic-stroke
#12
En-Sheng Yao, Yan Tang, Min-Jie Xie, Ming-Huan Wang, Hong Wang, Xiang Luo
BACKGROUND Hyperhomocysteinemia (HHcy) is a well-known risk factor for ischemic stroke. However, whether HHcy can influence the treatment outcome of acute ischemic stroke (AIS) patients has yet to be fully determined. In this study, we investigated the relationship between serum homocysteine (Hcy) level and prognosis in AIS patients who received tissue plasminogen activator (tPA) treatment. MATERIAL AND METHODS Patients were recruited according to the research criteria and grouped by their serum Hcy levels...
September 15, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27561255/association-between-serum-non-high-density-lipoprotein-cholesterol-and-cognitive-impairment-in-patients-with-acute-ischemic-stroke
#13
Da Lu, Pan Li, Yuying Zhou, Xiaolin Xu, Huihong Zhang, Liping Liu, Zhiyan Tian
BACKGROUND: Non-high density lipoprotein cholesterol (HDL-C) could be a good predictor of vascular disease outcomes. To evaluate the association between serum non-HDL-C and cognitive impairment in patients with acute ischemic stroke. METHODS: A total of 725 hospitalized patients with acute ischemic stroke were enrolled. They received conventional treatment. Cognitive function was assessed on the 3rd day after admission using mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), Activity of Daily Living Scale (ADL), and Neuropsychiatric Inventory (NPI, and Hamilton depression rating scale 21-item (HAMD-21)...
August 26, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27558379/circulating-biomarkers-and-incident-ischemic-stroke-in-the-framingham-offspring-study
#14
Ashkan Shoamanesh, Sarah R Preis, Alexa S Beiser, Carlos S Kase, Philip A Wolf, Ramachandran S Vasan, Emelia J Benjamin, Sudha Seshadri, Jose R Romero
OBJECTIVE: We related a panel of inflammatory biomarkers to risk of incident ischemic stroke (IIS) in a community-dwelling sample. METHODS: Stroke-free Framingham offspring attending examination cycle 7 (1998-2001) had 15 circulating inflammatory biomarkers measured. Cox proportional hazard models were used to calculate the hazard ratios (HRs) of IIS per SD increment of each biomarker. Model 1 included age and sex. Model 2 additionally adjusted for systolic blood pressure, hypertension treatment, current smoking, diabetes, cardiovascular disease, and atrial fibrillation...
September 20, 2016: Neurology
https://www.readbyqxmd.com/read/27554075/independent-correlation-of-serum-homocysteine-with-cerebral-microbleeds-in-patients-with-acute-ischemic-stroke-due-to-large-artery-atherosclerosis
#15
Bian-Rong Wang, Zhou Ou, Teng Jiang, Ying-Dong Zhang, Hong-Dong Zhao, You-Yong Tian, Jian-Quan Shi, Jun-Shan Zhou
BACKGROUND AND AIM: The severity of cerebral microbleeds (CMBs) affected the prognosis of patients with acute cerebrovascular disease. Considering the impact of CMBs on clinical decision, it is necessary to assess the risk factors of CMBs. We aimed to evaluate the independent risk factors of CMBs in patients with acute ischemic stroke of large-artery atherosclerosis. MATERIALS AND METHODS: 112 patients were enrolled in the study. The baseline information, the results of laboratory examination and cranial MRI were collected...
August 20, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27528407/folic-acid-supplementation-and-the-risk-of-cardiovascular-diseases-a-meta-analysis-of-randomized-controlled-trials
#16
Yanping Li, Tianyi Huang, Yan Zheng, Tauland Muka, Jenna Troup, Frank B Hu
BACKGROUND: Results from observational and genetic epidemiological studies suggest that lower serum homocysteine levels are associated with lower incidence of cardiovascular disease (CVD). Numerous randomized controlled trials have investigated the efficacy of lowering homocysteine with folic acid supplementation for CVD risk, but conflicting results have been reported. METHODS AND RESULTS: Three bibliographic databases (Medline, Embase, and the Cochrane Database of Systematic Reviews) were searched from database inception until December 1, 2015...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27507861/nonatheroscleotic-isolated-middle-cerebral-artery-disease-may-be-early-manifestation-of-moyamoya-disease
#17
Yeon-Jung Kim, Joo Kyung Lee, Sung-Ho Ahn, Bum Joon Kim, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND AND PURPOSE: Middle cerebral artery steno-occlusive disease (MCAD) is not an uncommon cause of ischemic stroke in young Asians. Aside from atherosclerosis, the pathogenesis of MCAD include various nonatherosclerotic vasculopathies, most of which are yet to be defined. This study investigated the pathogenesis of symptomatic isolated MCAD in young Asian patients using high-resolution magnetic resonance imaging (HR-MRI) and mutation analysis of RNF213. METHODS: Patients aged <60 years with stroke or transient ischemic attack caused by MCAD were prospectively enrolled...
September 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27462097/homocysteine-lowering-for-stroke-prevention-unravelling-the-complexity-of-the-evidence
#18
J David Spence
Elevated levels of total homocysteine impair endothelial dysfunction and increase thrombosis. Homocysteine is causal in animal models, and in human studies, elevated total homocysteine is significantly associated with carotid atherosclerosis, lacunar infarction, and markedly increased risk of stroke in atrial fibrillation. Because two of the early large trials of B vitamin therapy (Vitamin Intervention for Stroke Prevention and the Norwegian Vitamin Study) did not show any reduction of stroke, and the Heart Outcomes Prevention Evaluation 2 trial was mistakenly interpreted as not showing a reduction of stroke (because the authors could not think of a biological difference between stroke and myocardial infarction), there has been widespread pessimism regarding treatment to lower total homocysteine for stroke prevention...
October 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27455253/homocysteine-aggravates-cortical-neural-cell-injury-through-neuronal-autophagy-overactivation-following-rat-cerebral-ischemia-reperfusion
#19
Yaqian Zhao, Guowei Huang, Shuang Chen, Yun Gou, Zhiping Dong, Xumei Zhang
Elevated homocysteine (Hcy) levels have been reported to be involved in neurotoxicity after ischemic stroke. However, the underlying mechanisms remain incompletely understood to date. In the current study, we hypothesized that neuronal autophagy activation may be involved in the toxic effect of Hcy on cortical neurons following cerebral ischemia. Brain cell injury was determined by hematoxylin-eosin (HE) staining and TdT-mediated dUTP Nick-End Labeling (TUNEL) staining. The level and localization of autophagy were detected by transmission electron microscopy, western blot and immunofluorescence double labeling...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27454859/using-multicountry-ecological-and-observational-studies-to-determine-dietary-risk-factors-for-alzheimer-s-disease
#20
William B Grant
UNLABELLED: Rates of Alzheimer's disease (AD) are rising worldwide. The most important risk factors seem to be linked to diet. For example, when Japan made the nutrition transition from the traditional Japanese diet to the Western diet, AD rates rose from 1% in 1985 to 7% in 2008. Foods protective against AD include fruits, vegetables, grains, low-fat dairy products, legumes, and fish, whereas risk factors include meat, sweets, and high-fat dairy products. The evidence comes from ecological and observational studies as well as investigations of the mechanisms whereby dietary factors affect risk...
July 2016: Journal of the American College of Nutrition
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