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Homocysteine and stroke

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https://www.readbyqxmd.com/read/28925645/vitamin-b12-deficiency-recognition-and-management
#1
Robert C Langan, Andrew J Goodbred
Vitamin B12 deficiency is a common cause of megaloblastic anemia, various neuropsychiatric symptoms, and other clinical manifestations. Screening average-risk adults for vitamin B12 deficiency is not recommended. Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years...
September 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28923114/homocysteine-exaggerates-microglia-activation-and-neuroinflammation-through-microglia-localized-stat3-overactivation-following-ischemic-stroke
#2
Shuang Chen, Zhiping Dong, Man Cheng, Yaqian Zhao, Mengying Wang, Na Sai, Xuan Wang, Huan Liu, Guowei Huang, Xumei Zhang
BACKGROUND: Elevated plasma homocysteine (Hcy) levels have been indicated as a strong and modifiable risk factor of ischemic stroke; the previous studies have shown that exposure to Hcy activates cultured microglia. However, whether neurotoxicity of Hcy involves microglia activation following brain ischemia and the underlying mechanisms remains incompletely understood. METHODS: The cerebral damage was evaluated by staining with 2,3,5-triphenyltetrazolium chloride, hematoxylin-eosin, and Fluoro Jade B...
September 18, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28912716/a-meta-analysis-of-folic-acid-in-combination-with-anti-hypertension-drugs-in-patients-with-hypertension-and-hyperhomocysteinemia
#3
REVIEW
Wen-Wen Wang, Xin-Shi Wang, Zeng-Rui Zhang, Jin-Cai He, Cheng-Long Xie
Folic acid is generally used to lower homocysteine concentrations and prevent stroke and cardiovascular disease (CVD) at present. However, the efficacy of therapies that lower homocysteine concentrations in reducing the risk of CVD and stroke remains controversial. Our objective was to do a meta-analysis of relevant randomized controlled trials (RCTs) to evaluate the efficacy of folic acid supplementation among patients with hypertension and Hyperhomocysteinemia (HT/HHcy). We included RCTs examining the effects of folic acid plus antihypertensive therapy compared to antihypertensive alone...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28892878/role-of-anthropometric-measurements-in-development-of-cvd-and-stroke-among-t2dm-in-east-godavari-district-andhra-pradesh-india
#4
Mortha Kiran Deedi, Alavala Matta Reddy, Nelakuditi Lakshmana Kumar
INTRODUCTION: Cardiovascular morbidity and mortality have been associated with different variables of anthropometric measurements. AIM: To find out the association of anthropometric measurements in the development of Cardiovascular Disease (CVD) and stroke among Type 2 Diabetes Mellitus (T2DM). MATERIALS AND METHODS: Three hundred subjects were included in the study out of which 100 subjects were known type 2 diabetics with CVD or Stroke (Group 1), 100 subjects were type 2 diabetic patients (Group 2) and 100 subjects were normal and healthy (Group 3)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28867034/-neonatal-arterial-ischemic-stroke-which-thrombotic-biological-risk-factors-to-investigate-and-which-practical-consequences
#5
T Perez, J B Valentin, E Saliba, Y Gruel
All biological risk factors that have been previously identified to increase the risk of thrombosis in adults, have also been studied in neonates with arterial Ischemic Stroke (NAIS), but most studies were retrospective and included relatively low numbers of affected children. We therefore could not suggest recommendations with a strong level of evidence and only expert proposals potentially useful for clinical practice will be presented in this text. Despite these limitations, the extensive analysis of published data supported that factor V Leiden (FVL) and increased levels of Lp(a) could be significant risk factors for NAIS...
September 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28854002/efficacy-of-folic-acid-therapy-in-patients-with-hyperhomocysteinemia
#6
Huizi Tian, Dandan Tian, Chengda Zhang, Wenhua Wang, Lianke Wang, Mengying Ge, Quanliang Hou, Weidong Zhang
BACKGROUND: Increased plasma homocysteine (Hcy) levels are a risk factor for stroke and can be reduced with folic acid therapy. Therefore, it is extremely important for patients with hyperhomocysteinemia (HHcy) to obtain the normal level of Hcy after folate intervention. Thus far, few studies have reported the effective rate defined as percentage of patients who achieved normal plasma Hcy levels after folic acid therapy. OBJECTIVES: The present study aimed to investigate the effective rate of folic acid for the treatment of HHcy and the impact of plasma baseline Hcy levels and the compliance of oral folic acid on the efficacy...
August 30, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28846725/elevated-plasma-homocysteine-upon-ischemic-stroke-is-associated-with-increased-long-term-mortality-in-women
#7
Ioanna Markaki, Stefanos Klironomos, Konstantinos Kostulas, Christina Sjostrand
BACKGROUND: Ischemic stroke is a leading cause of death worldwide, despite preventive and therapeutic advances during the last twenty years. Blood-borne biomarkers have been studied in association to short- and long-term outcome, in order to investigate possible modifiable predictors of disability and death. Increased homocysteine has been associated with increased vascular risk and unfavorable outcome, but homocysteine lowering treatment has not consistently been successful in risk reduction...
2017: PloS One
https://www.readbyqxmd.com/read/28816346/homocysteine-lowering-interventions-for-preventing-cardiovascular-events
#8
REVIEW
Arturo J Martí-Carvajal, Ivan Solà, Dimitrios Lathyris, Mark Dayer
BACKGROUND: Cardiovascular disease, which includes coronary artery disease, stroke and peripheral vascular disease, is a leading cause of death worldwide. Homocysteine is an amino acid with biological functions in methionine metabolism. A postulated risk factor for cardiovascular disease is an elevated circulating total homocysteine level. The impact of homocysteine-lowering interventions, given to patients in the form of vitamins B6, B9 or B12 supplements, on cardiovascular events has been investigated...
August 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28816120/b-vitamins-in-stroke-prevention-time-to-reconsider
#9
REVIEW
J David Spence, Qilong Yi, Graeme J Hankey
B vitamin therapy lowers plasma total homocysteine concentrations, and might be a beneficial intervention for stroke prevention; however, cyanocobalamin (a form of vitamin B12) can accelerate decline in renal function and increase the risk of cardiovascular events in patients with impaired renal function. Although early trials did not show benefit in reduction of stroke, these results might have been due to harm in participants with impaired renal function. In patients with diabetic nephropathy, cyanocobalamin is harmful, whereas B vitamins appear to reduce cardiovascular events in study participants with normal renal function...
September 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28756014/caffeine-and-cardiovascular-health
#10
Duncan Turnbull, Joseph V Rodricks, Gregory F Mariano, Farah Chowdhury
This report evaluates the scientific literature on caffeine with respect to potential cardiovascular outcomes, specifically relative risks of total cardiovascular disease (CVD), coronary heart disease (CHD) and acute myocardial infarction (AMI), effects on arrhythmia, heart failure, sudden cardiac arrest, stroke, blood pressure, hypertension, and other biomarkers of effect, including heart rate, cerebral blood flow, cardiac output, plasma homocysteine levels, serum cholesterol levels, electrocardiogram (EKG) parameters, heart rate variability, endothelial/platelet function and plasma/urine catecholamine levels...
October 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28754404/relevance-of-plasma-levels-of-free-homocysteine-and-methionine-as-risk-predictors-for-ischemic-stroke-in-the-young
#11
Kondapura Jayadevappa Rudreshkumar, Vijaya Majumdar, Dindagur Nagaraja, Rita Christopher
BACKGROUND & AIMS: The debated vascular risk potential of total homocysteine (tHcy), due to failed clinical trials designed on B vitamin supplementation, raises many possible explanations like the higher risk potential of the deleterious, free form of homocysteine (fHcy) or, the unchecked confounding effects of B-vitamins in tHcy-based association studies. Additionally, the cardiovascular risk probability of altered status of the homocysteine precursor, methionine (tMet) could shed light on the causality of association between tHcy and cardiovascular diseases...
July 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28748495/evidence-for-interactions-between-homocysteine-and-genistein-insights-into-stroke-risk-and-potential-treatment
#12
Zyta Banecka-Majkutewicz, Leszek Kadziński, Michał Grabowski, Sylwia Bloch, Rajmund Kaźmierkiewicz, Joanna Jakóbkiewicz-Banecka, Magdalena Gabig-Cimińska, Grzegorz Węgrzyn, Alicja Węgrzyn, Bogdan Banecki
Elevated plasma homocysteine (2-amino-4-sulfanylbutanoic acid) level is a risk factor for stroke. Moreover, it has been suggested that high levels of homocysteine in the acute phase of an ischemic stroke can predict mortality, especially in stroke patients with the large-vessel atherosclerosis subtype. In clinical studies, supplementation with genistein (5, 7-dihydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one) decreased plasma homocysteine levels considerably. Therefore, genistein could be considered as a potential drug for prevention and/or treatment of stroke...
July 26, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28721209/recent-advances-in-preventing-stroke-recurrence
#13
REVIEW
J David Spence
Recent advances in secondary stroke prevention include new evidence in hypertension, nutrition, anticoagulation, antiplatelet therapy, intracranial stenosis, percutaneous closure of patent foramen ovale, and lipid-lowering therapy. Individualized therapy for hypertension based on phenotyping with plasma renin and aldosterone markedly improves blood pressure control in patients with resistant hypertension. A Mediterranean diet can reduce the risk of stroke by nearly half. The diagnosis and treatment of metabolic vitamin B12 deficiency, and B vitamins to lower homocysteine, can reduce the risk of stroke by approximately 30%...
2017: F1000Research
https://www.readbyqxmd.com/read/28705458/insulin-resistance-and-elevated-c-reactive-protein-among-first-degree-relatives-of-ischemic-stroke-patients
#14
Krishnamoorthy Srilatha, Zachariah Bobby, D K Subrahmanyam, Uppoor NithinKumar
BACKGROUND: Family history is one of the non-modifiable risk factors for ischemic stroke. Atherosclerosis and thrombosis are the two major mechanisms for cardiovascular disease and stroke. Screening of family members is an important method to identify individuals at risk. Therefore, this study was planned to assess the atherosclerotic risk factors in first-degree relatives of patients with ischemic stroke. METHODOLOGY: Case group included 40 first-degree relatives of ischemic stroke patients between 30 and 50 years of age...
July 4, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28663544/plasma-homocysteine-and-cerebral-small-vessel-disease-as-possible-mediators-between-kidney-and-cognitive-functions-in-patients-with-diabetes-mellitus
#15
Mika Sonoda, Tetsuo Shoji, Yukinobu Kuwamura, Yujiro Okute, Toshihide Naganuma, Hideaki Shima, Koka Motoyama, Tomoaki Morioka, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Taro Shimono, Hisako Fujii, Daijiro Kabata, Ayumi Shintani, Masanori Emoto, Masaaki Inaba
Cognitive impairment is more prevalent in those with decreased kidney function. We tested a hypothesis that an increased homocysteine and/or cerebral small vessel diseases (SVDs) mediate the link between kidney and cognitive functions in a cross-sectional study in 143 type 2 diabetes patients without diagnosis of dementia or prior stroke. The exposure and outcome variables were estimated glomerular filtration rate (eGFR) and cognitive performance evaluated with Modified Mini-Mental State (3 MS) examination, respectively...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614786/association-of-mir-146a-mir-149-mir-196a2-mir-499-gene-polymorphisms-with-ischemic-stroke-in-a-chinese-people
#16
Hong-Cheng Luo, Qi-Sheng Luo, Chun-Fang Wang, Ming Lei, Bei-Lin Li, Ye-Sheng Wei
This study aimed to investigate genetic polymorphisms of miR-146a, miR-149, miR-196a2, and miR-499 and genetic susceptibility of ischemic stroke in the population of Guangxi in China. A case-control study was used to investigate miRNAs genetic polymorphisms in 298 patients with ischemic stroke and 303 healthy controls. Single-base extension polymerase chain reaction genotyping principle was used to detect genetic polymorphisms of miRNAs,and the relationship of genotype in each group and blood lipid was compared and analyzed...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544117/increased-expression-of-stim1-orai1-in-platelets-of-stroke-patients-predictive-of-poor-outcomes
#17
M Dong, N Zheng, L J Ren, H Zhou, J Liu
BACKGROUND AND PURPOSE: The platelet activation that is mediated by store-operated Ca(2+) entry via stromal interaction molecule (STIM1) and Orai1 Ca(2+) influx channels has been shown to play a key role in ischaemic stroke (IS). This study aimed to evaluate the impact of platelet STIM1/Orai1 protein expression on outcomes of IS. METHODS: A total of 160 patients with acute non-cardioembolic IS, among whom 45 patients had small-vessel diseases and 115 patients had large-vessel diseases, were evaluated...
July 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28524030/-preventive-effect-of-vitamin-b-supplementation-on-recurrent-stroke-a-meta-analysis
#18
Guining Dai, Hongzhen Du, Hongmin Wang, Yujia Wei, Ying Xie, Zengning Li
OBJECTIVE: To evaluate whether Vitamin B supplementation could prevent ischemic stroke recurrence. METHODS: Randomized controlled trials (RCTs) observing Vitamin B supplementation in patients with stroke was performed in databases including ScienceDirect, PubMed/Medline, China National Knowledge Infrastructure, Chinese Biomedical Data-Base, Wanfang Database, and VIP Chinese Science and Technology Journal Database to find related studies in English or Chinese published before August 2016...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28477314/the-role-of-emerging-risk-factors-in-cardiovascular-outcomes
#19
REVIEW
Ben Lacey, William G Herrington, David Preiss, Sarah Lewington, Jane Armitage
PURPOSE OF REVIEW: This review discusses the recent evidence for a selection of blood-based emerging risk factors, with particular reference to their relation with coronary heart disease and stroke. RECENT FINDINGS: For lipid-related emerging risk factors, recent findings indicate that increasing high-density lipoprotein cholesterol is unlikely to reduce cardiovascular risk, whereas reducing triglyceride-rich lipoproteins and lipoprotein(a) may be beneficial. For inflammatory and hemostatic biomarkers, genetic studies suggest that IL-6 (a pro-inflammatory cytokine) and several coagulation factors are causal for cardiovascular disease, but such studies do not support a causal role for C-reactive protein and fibrinogen...
June 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28471900/early-carotid-occlusion-after-endarterectomy-in-a-patient-with-a-mutation-for-mthfr-a1298c-polymorphism
#20
Simone Vidale, Silvio Bellocchi, Paolo Casiraghi, Roberto Caronno, Marco Arnaboldi
INTRODUCTION: Significant carotid stenosis is a well-documented risk factor for ischemic stroke. Carotid endarterectomy (CEA) and carotid artery stenting are effective procedures for the prevention of stroke in patients with this disease. However, the occurrence of restenosis could contribute to an increase in the risk of ischemic stroke. CASE REPORT: A 79-year-old woman was admitted to the Neurosurgical Department to undergo a CEA because of a progressive stenosis...
May 2017: Neurologist
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