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https://www.readbyqxmd.com/read/27921244/towards-green-oviposition-deterrents-effectiveness-of-syzygium-lanceolatum-myrtaceae-essential-oil-against-six-mosquito-vectors-and-impact-on-four-aquatic-biological-control-agents
#1
Giovanni Benelli, Mohan Rajeswary, Marimuthu Govindarajan
Essential oils (EOs) from plants may be alternative sources of molecules toxic against mosquito vectors of public health relevance. Most of researches in this field focused on EOs as larvicides or ovicides, while limited efforts focused on the exploitation of EOs as oviposition deterrents. In the present study, the larvicidal and oviposition deterrent activity of Syzygium lanceolatum leaf EO was evaluated against six mosquito species, Anopheles stephensi, An. subpictus, Aedes aegypti, Ae. albopictus, Culex quinquefasciatus, and Cx...
December 5, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27919210/three-dimensional-modelling-of-the-voltage-gated-sodium-ion-channel-from-anopheles-gambiae-reveals-spatial-clustering-of-evolutionarily-conserved-acidic-residues-at-the-extracellular-sites
#2
Rithvik S Vinekar, Ramanathan Sowdhamini
The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. A homology model of the transmembrane and extracellular regions of an Anopheles gambiae para-like channel with emphasis on the pore entrance has been constructed, based upon the templates provided by a prokaryotic sodium channel and a potassium two-pore channel. The latter provides a template for the extracellular regions, which are located above the entrance to the pore, which is likely to open at a side of a dome formed by these loops...
December 5, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27918946/toxicity-of-ar-curcumene-and-epi-%C3%AE-bisabolol-from-hedychium-larsenii-zingiberaceae-essential-oil-on-malaria-chikungunya-and-japanese-encephalitis-mosquito-vectors
#3
Mashael Marzouq AlShebly, Fatma Saeed AlQahtani, Marimuthu Govindarajan, Kasi Gopinath, Periasamy Vijayan, Giovanni Benelli
Mosquitoes act as vectors of key pathogens and parasites. Plant essential oils have been recognized as important sources of biopesticides, which do not induce resistance and have limited toxic effects on human health and non-target organisms. In this research, we evaluated the larvicidal and oviposition deterrence activity of Hedychium larsenii essential oil (EO) and its major compounds ar-curcumene and epi-β-bisabolol. Both molecules showed high toxicity against early third instars of Anopheles stephensi (LC50=10...
December 2, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27918584/the-ace-1-locus-is-amplified-in-all-resistant-anopheles-gambiae-mosquitoes-fitness-consequences-of-homogeneous-and-heterogeneous-duplications
#4
Benoît S Assogba, Pascal Milesi, Luc S Djogbénou, Arnaud Berthomieu, Patrick Makoundou, Lamine S Baba-Moussa, Anna-Sophie Fiston-Lavier, Khalid Belkhir, Pierrick Labbé, Mylène Weill
Gene copy-number variations are widespread in natural populations, but investigating their phenotypic consequences requires contemporary duplications under selection. Such duplications have been found at the ace-1 locus (encoding the organophosphate and carbamate insecticides' target) in the mosquito Anopheles gambiae (the major malaria vector); recent studies have revealed their intriguing complexity, consistent with the involvement of various numbers and types (susceptible or resistant to insecticide) of copies...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/27918451/bioactivities-of-a-new-pyrrolidine-alkaloid-from-the-root-barks-of-orixa-japonica
#5
Xin Chao Liu, Daowan Lai, Qi Zhi Liu, Ligang Zhou, Qiyong Liu, Zhi Long Liu
A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and MS analysis. The compound exhibited larvicidal activity against the fourth instar larvae of Aedes aegypti (LC50 = 232.09 μg/mL), Anopheles sinensis (LC50 = 49.91 μg/mL), and Culex pipiens pallens (LC50 = 161.10 μg/mL). The new alkaloid also possessed nematicidal activity against Bursaphelenchus xylophilus (LC50 = 391...
December 2, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27917832/1-45%C3%A2-%C3%A3-resolution-structure-of-srpn18-from-the-malaria-vector-anopheles-gambiae
#6
David A Meekins, Xin Zhang, Kevin P Battaile, Scott Lovell, Kristin Michel
Serine protease inhibitors (serpins) in insects function within development, wound healing and immunity. The genome of the African malaria vector, Anopheles gambiae, encodes 23 distinct serpin proteins, several of which are implicated in disease-relevant physiological responses. A. gambiae serpin 18 (SRPN18) was previously categorized as non-inhibitory based on the sequence of its reactive-center loop (RCL), a region responsible for targeting and initiating protease inhibition. The crystal structure of A. gambiae SRPN18 was determined to a resolution of 1...
December 1, 2016: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/27914545/potential-mode-of-action-of-a-novel-plumbagin-as-a-mosquito-repellent-against-the-malarial-vector-anopheles-stephensi-culicidae-diptera
#7
Venkatraman Pradeepa, Sengottayan Senthil-Nathan, Subbiah Sathish-Narayanan, Selvaraj Selin-Rani, Prabhakaran Vasantha-Srinivasan, Annamalai Thanigaivel, Athirstam Ponsankar, Edward-Sam Edwin, Muthiah Sakthi-Bagavathy, Kandaswamy Kalaivani, Kadarkarai Murugan, Veeramuthu Duraipandiyan, Naif Abdullah Al-Dhabi
Plumbagin was isolated and characterized from the roots of Plumbago zeylanica using chromatography: TLC, Column chromatogram, HPLC, FTIR and (1)H NMR. The isolated pure compounds were assayed for potency as inhibitors of: acetylcholine esterase (AchE), glutathione S-transferases (GST), superoxide dismutase (SOD), cytochrome P450 and α, β-esterase, and for repellency with Anopheles stephensi at four different concentrations (25, 50, 75 and 100ppm). The enzyme assay against the pure compound reveals that the level of esterase and SOD was decreased significantly in contrast the level of GST and cytochrome P450 was increased significantly...
November 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27912876/in-vitro-and-ex-vivo-activity-of-an-azadirachta-indica-a-juss-seed-kernel-extract-on-early-sporogonic-development-of-plasmodium-in-comparison-with-azadirachtin-a-its-most-abundant-constituent
#8
Nisha Dahiya, Giuseppina Chianese, Solomon Mequanente Abay, Orazio Taglialatela-Scafati, Fulvio Esposito, Giulio Lupidi, Massimo Bramucci, Luana Quassinti, George Christophides, Annette Habluetzel, Leonardo Lucantoni
BACKGROUND: NeemAzal(®) (NA) is a quantified extract from seed kernels of neem, Azadirachta indica A.Juss. (Meliaceae), with a wide spectrum of biological properties, classically ascribed to its limonoid content. NA contains several azadirachtins (A to L), azadirachtin A (AzaA) being its main constituent. AzaA has been shown to inhibit microgamete formation of the rodent malaria parasite Plasmodium berghei, and NA was found to completely inhibit the transmission of Plasmodium berghei to Anopheles stephensi mosquitoes when administered to gametocytemic mice at a corresponding AzaA dose of 50mg/kg before exposure to mosquitoes...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912789/dynamics-of-antigenemia-and-transmission-intensity-of-wuchereria-bancrofti-following-cessation-of-mass-drug-administration-in-a-formerly-highly-endemic-region-of-mali
#9
Yaya I Coulibaly, Siaka Y Coulibaly, Housseini Dolo, Siaka Konate, Abdallah A Diallo, Salif S Doumbia, Lamine Soumaoro, Michel E Coulibaly, Ilo Dicko, Moussa B Sangare, Benoit Dembele, Modibo Sangare, Massitan Dembele, Yeya T Touré, Louise Kelly-Hope, Katja Polman, Dominique Kyelem, Sekou F Traore, Moses Bockarie, Amy D Klion, Thomas B Nutman
BACKGROUND: After seven annual rounds of mass drug administration (MDA) in six Malian villages highly endemic for Wuchereria bancrofti (overall prevalence rate of 42.7%), treatment was discontinued in 2008. Surveillance was performed over the ensuing 5 years to detect recrudescence. METHODS: Circulating filarial antigen (CFA) was measured using immunochromatographic card tests (ICT) and Og4C3 ELISA in 6-7 year-olds. Antibody to the W. bancrofti infective larval stage (L3) antigen, Wb123, was tested in the same population in 2012...
December 3, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27911924/plasmodium-yoelii-nigeriensis-n67-is-a-robust-animal-model-to-study-malaria-transmission-by-south-american-anopheline-mosquitoes
#10
Alessandra S Orfano, Ana Paula M Duarte, Alvaro Molina-Cruz, Paulo F Pimenta, Carolina Barillas-Mury
Malaria is endemic in the American continent and the Amazonian rainforest is the region with the highest risk of transmission. However, the lack of suitable experimental models to infect malaria vectors from the Americas has limited the progress to understand the biology of transmission in this region. Anopheles aquasalis, a major vector in coastal areas of South America, was found to be highly refractory to infection with two strains of Plasmodium falciparum (NF54 and 7G8) and with Plasmodium berghei (mouse malaria), even when the microbiota was eliminated with antibiotics and oxidative stress was reduced with uric acid...
2016: PloS One
https://www.readbyqxmd.com/read/27910908/larval-diet-affects-mosquito-development-and-permissiveness-to-plasmodium-infection
#11
Inbar Linenberg, George K Christophides, Mathilde Gendrin
The larval stages of malaria vector mosquitoes develop in water pools, feeding mostly on microorganisms and environmental detritus. Richness in the nutrient supply to larvae influences the development and metabolism of larvae and adults. Here, we investigated the effects of larval diet on the development, microbiota content and permissiveness to Plasmodium of Anopheles coluzzii. We tested three fish diets often used to rear mosquitoes in the laboratory, including two pelleted diets, Dr. Clarke's Pool Pellets and Nishikoi Fish Pellets, and one flaked diet, Tetramin Fish-Flakes...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908745/effect-of-temperature-and-search-area-on-the-functional-response-of-anisops-sardea-hemiptera-notonectidae-against-anopheles-stephensi-in-laboratory-bioassay
#12
Rajendra Prasad Mondal, Goutam Chandra, Subhasis Bandyopadhyay, Anupam Ghosh
Present study was carried out to establish the influence of abiotic factors on foraging activities of a predatory hemipteran insect Anisops sardea against Anopheles stephensi larvae. The functional response of A. sardea was evaluated in variable density of prey items with variation in search area (100, 250, 500 and 1000ml water volume) and temperatures (20, 25 and 30°C). The results of laboratory bioassay revealed that prey consumption rate of predator species was positively related with increasing temperature and inversely related with increasing search area...
November 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27907857/membrane-effects-of-dihydropyrimidine-analogues-with-larvicidal-activity
#13
Mariela E Sánchez-Borzone, Maria E Mariani, Virginia Miguel, Raquel M Gleiser, Bharti Odhav, Katharigatta N Venugopala, Daniel A García
Two recently synthesized dihydropyrimidines (DHPMs) analogues have demonstrated larvicide and repellent activity against Anopheles arabiensis. DHPMs high lipophilicity suggests that these compounds may interact directly with the membrane and modify their biophysical properties. The purpose of the present study was to characterize the interaction of both compounds with artificial membranes. Changes on the properties of DPPC films were studied using Langmuir monolayers. The presence of DHPMs in the subphase modified the interfacial characteristics of DPPC compression isotherms, causing the expansion of the monolayer, inducing the disappearance of DPPC phase transition and increasing the molecular packing of the film...
November 24, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27906962/population-density-climate-variables-and-poverty-synergistically-structure-spatial-risk-in-urban-malaria-in-india
#14
Mauricio Santos-Vega, Menno J Bouma, Vijay Kohli, Mercedes Pascual
BACKGROUND: The world is rapidly becoming urban with the global population living in cities projected to double by 2050. This increase in urbanization poses new challenges for the spread and control of communicable diseases such as malaria. In particular, urban environments create highly heterogeneous socio-economic and environmental conditions that can affect the transmission of vector-borne diseases dependent on human water storage and waste water management. Interestingly India, as opposed to Africa, harbors a mosquito vector, Anopheles stephensi, which thrives in the man-made environments of cities and acts as the vector for both Plasmodium vivax and Plasmodium falciparum, making the malaria problem a truly urban phenomenon...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27905919/susceptibility-of-anopheles-gambiae-to-insecticides-used-for-malaria-vector-control-in-rwanda
#15
Emmanuel Hakizimana, Corine Karema, Dunia Munyakanage, Gad Iranzi, John Githure, Jon Eric Tongren, Willem Takken, Agnes Binagwaho, Constantianus J M Koenraadt
BACKGROUND: The widespread emergence of resistance to pyrethroids is a major threat to the gains made in malaria control. To monitor the presence and possible emergence of resistance against a variety of insecticides used for malaria control in Rwanda, nationwide insecticide resistance surveys were conducted in 2011 and 2013. METHODS: Larvae of Anopheles gambiae sensu lato mosquitoes were collected in 12 sentinel sites throughout Rwanda. These were reared to adults and analysed for knock-down and mortality using WHO insecticide test papers with standard diagnostic doses of the recommended insecticides...
December 1, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27903292/evaluation-of-long-lasting-microbial-larvicide-for-malaria-vector-control-in-kenya
#16
Yaw A Afrane, Nixon G Mweresa, Christine L Wanjala, Thomas M Gilbreath Iii, Guofa Zhou, Ming-Chieh Lee, Andrew K Githeko, Guiyun Yan
BACKGROUND: Outdoor malaria transmission is becoming an increasingly important problem in malaria control in Africa. Larval control is a promising intervention as it can target both indoor and outdoor biting mosquitoes. However, the currently available biolarvicide formulations have a short effective duration, and consequently larval control incurs a high operational expense due to the requirement for frequent re-treatment of larval habitats. Formulations of biolarvicides with long-lasting effects is highly desired...
December 1, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27903054/future-malaria-spatial-pattern-based-on-the-potential-global-warming-impact-in-south-and-southeast-asia
#17
Hassan M Khormi, Lalit Kumar
We used the Model for Interdisciplinary Research on Climate-H climate model with the A2 Special Report on Emissions Scenarios for the years 2050 and 2100 and CLIMEX software for projections to illustrate the potential impact of climate change on the spatial distributions of malaria in China, India, Indochina, Indonesia, and The Philippines based on climate variables such as temperature, moisture, heat, cold and dryness. The model was calibrated using data from several knowledge domains, including geographical distribution records...
November 21, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27901056/rice-volatiles-lure-gravid-malaria-mosquitoes-anopheles-arabiensis
#18
Betelehem Wondwosen, Göran Birgersson, Emiru Seyoum, Habte Tekie, Baldwyn Torto, Ulrike Fillinger, Sharon R Hill, Rickard Ignell
Mosquito oviposition site selection is essential for vector population dynamics and malaria epidemiology. Irrigated rice cultivations provide ideal larval habitats for malaria mosquitoes, which has resulted in increased prevalence of the malaria vector, Anopheles arabiensis, in sub-Saharan Africa. The nature and origin of the cues regulating this behaviour are only now being elucidated. We show that gravid Anopheles arabiensis are attracted and oviposit in response to the odour present in the air surrounding rice...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895273/results-from-the-workshop-problem-formulation-for-the-use-of-gene-drive-in-mosquitoes
#19
Andrew Roberts, Paulo Paes de Andrade, Fredros Okumu, Hector Quemada, Moussa Savadogo, Jerome Amir Singh, Stephanie James
Reducing the incidence of malaria has been a public health priority for nearly a century. New technologies and associated vector control strategies play an important role in the prospect of sustained reductions. The development of the CRISPR/Cas9 gene editing system has generated new possibilities for the use of gene-drive constructs to reduce or alter vector populations to reduce malaria incidence. However, before these technologies can be developed and exploited, it will be necessary to understand and assess the likelihood of any potential harms to humans or the environment...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27895131/the-p-falciparum-cell-traversal-protein-for-ookinetes-and-sporozoites-as-a-candidate-for-pre-erythrocytic-and-transmission-blocking-vaccines
#20
Diego A Espinosa, Joel Vega-Rodriguez, Yevel Flores-Garcia, Amy R Noe, Christian Muñoz, Russell Coleman, Torben Bruck, Keith Haney, Alex Stevens, Diane Retallack, Jeff Allen, Thomas S Vedvick, Christopher B Fox, Steven G Reed, Randall F Howard, Ahmed M Salman, Chris J Janse, Shahid M Khan, Fidel Zavala, Gabriel M Gutierrez
Recent studies have shown that immune responses against the Cell-Traversal Protein for Plasmodium Ookinetes and Sporozoites (CelTOS) can inhibit parasite infection. While these studies provide important evidence towards the development of vaccines targeting this protein, it remains unknown whether these responses could engage the P. falciparum CelTOS in vivo. Using a newly developed rodent malaria chimeric parasite expressing the P. falciparum CelTOS (PfCelTOS), we evaluated the protective effect of in vivo immune responses elicited by vaccination and assessed the neutralizing capacity of monoclonal antibodies specific against PfCelTOS...
November 28, 2016: Infection and Immunity
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