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https://www.readbyqxmd.com/read/28525804/recombinant-adeno-associated-virus-vector-carrying-the-thrombomodulin-lectin-like-domain-for-the-treatment-of-abdominal-aortic-aneurysm
#1
Chao-Han Lai, Kuan-Chieh Wang, Cheng-Hsiang Kuo, Fang-Tzu Lee, Tsung-Lin Cheng, Bi-Ing Chang, Yu-Jen Yang, Guey-Yueh Shi, Hua-Lin Wu
BACKGROUND AND AIMS: Thrombomodulin (TM), through its lectin-like domain (TMD1), sequesters proinflammatory high-mobility group box 1 (HMGB1) to prevent it from engaging the receptor for advanced glycation end product (RAGE) that sustains inflammation and tissue damage. Our previous study demonstrated that short-term treatment with recombinant TM containing all the extracellular domains (i.e., rTMD123) inhibits HMGB1-RAGE signaling and confers protection against CaCl2-induced AAA formation...
March 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28522560/the-effect-of-long-term-maternal-smoking-on-the-offspring-s-lung-health
#2
Suporn Sukjamnong, Yik Lung Chan, Razia Zakarya, Sonia Saad, Pawan Sharma, Rachana Santiyanont, Hui Chen, Brian G G Oliver
Maternal smoking during pregnancy contributes to long-term health problems in offspring, especially respiratory disorders which can manifest in either childhood or adulthood. Receptors for advanced glycation end-products (RAGE) are multi-ligand receptors abundantly localized in the lung, capable of responding to by-products of reactive oxygen species and pro-inflammatory responses. RAGE signalling is a key regulator of inflammation in cigarette smoking-related pulmonary diseases. However, the impact of maternal cigarette smoke exposure on lung RAGE signalling in the offspring is unclear...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28521879/a-quick-simple-method-for-detecting-circulating-fluorescent-advanced-glycation-end-products-correlation-with-in-vitro-and-in-vivo-non-enzymatic-glycation
#3
Marika Villa, Mariacristina Parravano, Arianna Micheli, Lucia Gaddini, Andrea Matteucci, Cinzia Mallozzi, Francesco Facchiano, Fiorella Malchiodi-Albedi, Flavia Pricci
OBJECTIVE: Advanced glycation end-products (AGEs) constitute a highly heterogeneous family of compounds, relevant in the pathogenesis of diabetic complications, which could represent efficient biomarkers of disease progression and drug response. Unfortunately, due to their chemical heterogeneity, no method has been validated to faithfully monitor their levels in the course of the disease. In this study, we refine a procedure to quantitatively analyze fluorescent AGEs (fAGEs), a subset considered remarkably representative of the entire AGE family, and measure them in in vitro glycated BSA (gBSA) and in plasma and vitreous of diabetic rats, for testing its use to possibly quantify circulating AGEs in patients, as markers of metabolic control...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28515150/receptor-for-advanced-glycation-end-products-is-targeted-by-fbxo10-for-ubiquitination-and-degradation
#4
John Evankovich, Travis Lear, Alison Mckelvey, Sarah Dunn, James Londino, Yuan Liu, Bill B Chen, Rama K Mallampalli
The receptor for advanced glycation end products (RAGE) is a highly expressed cell membrane receptor serving to anchor lung epithelia to matrix components, and it also amplifies inflammatory signaling during acute lung injury. However, mechanisms that regulate its protein concentrations in cells remain largely unknown. Here we show that RAGE exhibits an extended life span in lung epithelia (t½ 6 h), is monoubiquitinated at K374, and is degraded in lysosomes. The RAGE ligand ODN2006, a synthetic oligodeoxynucleotide resembling pathogenic hypomethylated CpG DNA, promotes rapid lysosomal RAGE degradation through activation of protein kinase C zeta (PKCζ), which phosphorylates RAGE...
May 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28512345/phosphoproteome-analysis-reveals-phosphorylation-underpinnings-in-the-brains-of-nurse-and-forager-honeybees-apis-mellifera
#5
Gebreamlak Bezabih, Han Cheng, Bin Han, Mao Feng, Yu Xue, Han Hu, Jianke Li
The honeybee brain is a central organ in regulating wide ranges of honeybee biology, including life transition from nurse to forager bees. Knowledge is still lacking on how protein phosphorylation governs the neural activity to drive the age-specific labor division. The cerebral phosphoproteome of nurse and forager honeybees was characterized using Ti(4+)-IMAC phosphopeptide enrichment mass-spectrometry-based proteomics and protein kinases (PKs) were predicted. There were 3,077 phosphosites residing on 3,234 phosphopeptides from 1004 phosphoproteins in the nurse bees...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28505121/molecular-pathways-involved-in-the-amelioration-of-myocardial-injury-in-diabetic-rats-by-kaempferol
#6
Kapil Suchal, Salma Malik, Sana Irfan Khan, Rajiv Kumar Malhotra, Sameer N Goyal, Jagriti Bhatia, Shreesh Ojha, Dharamvir Singh Arya
There is growing evidence that chronic hyperglycemia leads to the formation of advanced glycation end products (AGEs) which exerts its effect via interaction with the receptor for advanced glycation end products (RAGE). AGE-RAGE activation results in oxidative stress and inflammation. It is well known that this mechanism is involved in the pathogenesis of cardiovascular disease in diabetes. Kaempferol, a dietary flavonoid, is known to possess antioxidant, anti-apoptotic, and anti-inflammatory activities. However, little is known about the effect of kaempferol on myocardial ischemia-reperfusion (IR) injury in diabetic rats...
May 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28504654/sugar-makes-neutrophils-rage-linking-diabetes-associated-hyperglycemia-to-thrombocytosis-and-platelet-reactivity
#7
Robert H Lee, Wolfgang Bergmeier
Diabetes mellitus is associated with an increased risk for cardiovascular disease, but the link between hyperglycemia and atherothrombotic disease is not completely understood. Patients with diabetes often show hyporesponsiveness to antiplatelet therapies, and it has been suggested that hyperreactive reticulated platelets underlie this altered therapeutic response. In this issue of the JCI, Kraakman et al. uncover a previously unknown link between hyperglycemia and enhanced platelet production and reactivity...
May 15, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28504650/neutrophil-derived-s100-calcium-binding-proteins-a8-a9-promote-reticulated-thrombocytosis-and-atherogenesis-in-diabetes
#8
Michael J Kraakman, Man K S Lee, Annas Al-Sharea, Dragana Dragoljevic, Tessa J Barrett, Emilie Montenont, Debapriya Basu, Sarah Heywood, Helene L Kammoun, Michelle Flynn, Alexandra Whillas, Nordin M J Hanssen, Mark A Febbraio, Erik Westein, Edward A Fisher, Jaye Chin-Dusting, Mark E Cooper, Jeffrey S Berger, Ira J Goldberg, Prabhakara R Nagareddy, Andrew J Murphy
Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia, processes that are accelerated in diabetes. Whether hyperglycemia promotes platelet production and whether enhanced platelet production contributes to enhanced atherothrombosis remains unknown. Here we found that in response to hyperglycemia, neutrophil-derived S100 calcium-binding proteins A8/A9 (S100A8/A9) interact with the receptor for advanced glycation end products (RAGE) on hepatic Kupffer cells, resulting in increased production of IL-6, a pleiotropic cytokine that is implicated in inflammatory thrombocytosis...
May 15, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28498464/proinflammatory-effects-of-s100a8-a9-via-tlr4-and-rage-signaling-pathways-in-bv-2-microglial-cells
#9
Li Ma, Peng Sun, Jian-Cheng Zhang, Qing Zhang, Shang-Long Yao
S100A8/A9, a heterodimer of the two calcium-binding proteins S100A8 and S100A9, has emerged as an important proinflammatory mediator in acute and chronic inflammation. However, whether S100A8/A9 is implicated in microglial‑induced neuroinflammatory response remains unclear. Here, we found that S100A8/A9 significantly increased the secretion of proinflammatory cytokines inclu-ding tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cultured BV-2 microglial cells. Inhibition of the Toll-like receptor 4 (TLR4) and the receptor for advanced glycation end-products (RAGE) with C225 and a RAGE-blocking antibody, respectively significantly reduced the secretion of TNF-α and IL-6 from S100A8/A9-stimulated BV-2 microglial cells...
May 12, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28497345/retinol-vitamin-a-increases-%C3%AE-synuclein-%C3%AE-amyloid-peptide-tau-phosphorylation-and-rage-content-in-human-sh-sy5y-neuronal-cell-line
#10
Alice Kunzler, Eduardo Antônio Kolling, Jeferson Delgado da Silva-Jr, Juciano Gasparotto, Matheus Augusto de Bittencourt Pasquali, José Cláudio Fonseca Moreira, Daniel Pens Gelain
Retinoids (vitamin A and derivatives) are recognized as essential factors for central nervous system (CNS) development. Retinol (vitamin A) also was postulated to be a major antioxidant component of diet as it modulates reactive species (RS) production and oxidative stress in biological systems. Oxidative stress plays a major role either in pathogenesis or development of neurodegenerative diseases, or even in both. Here we investigate the role of retinol supplementation to human neuron-derived SH-SY5Y cells over RS production and biochemical markers associated to neurodegenerative diseases expressed at neuronal level in Parkinson's disease and Alzheimer's disease: α-synuclein, β-amyloid peptide, tau phosphorylation and RAGE...
May 11, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28486941/neuroprotective-effect-of-salvianolate-lyophilized-injection-against-cerebral-ischemia-in-type-1-diabetic-rats
#11
Fujiang Wang, Qiansong He, Jinxin Wang, Qing Yuan, Hong Guo, Lijuan Chai, Shaoxia Wang, Limin Hu, Yue Zhang
BACKGROUND: Salvianolate lyophilized injection (SLI) has been clinically used in China for the treatment of acutely cerebral infarction. Clinical and experimental studies have shown that Diabetes mellitus (DM) not only increases the risk of ischemic stroke recurrence but also leads to poor outcomes and increases fatality rates after stroke. Our previous study has proved that SLI can reduce the infarct volume after stroke in type 1 diabetic rats. The aim of the study is to explore the mechanism of SLI on stroke outcome in type 1 diabetic (T1DM) rats...
May 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28485798/immune-complexes-induce-tnf-%C3%AE-and-baff-production-from-u937-cells-by-hmgb1-and-rage
#12
X-J Gao, Y-Y Qu, X-W Liu, M Zhu, C-Y Ma, Y-L Jiao, B Cui, Z-J Chen, Y-R Zhao
OBJECTIVE: This study investigated the effects of immune complexes (ICs) on tumor necrosis factor α (TNF-α) and B cell-activating factor (BAFF) production from U937 cells and further explored the mechanism. MATERIALS AND METHODS: U937 cells were incubated with necrosis supernatant or systemic lupus erythematosus (SLE) sera alone, or their combination. The expression of TNF-α and BAFF was determined by Real-time polymerase chain reaction and enzyme-linked immunosorbent assay...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28484719/glycyrrhizin-protects-rats-from-sepsis-by-blocking-hmgb1-signaling
#13
Feng Zhao, Yong Fang, Shuixiang Deng, Xiantao Li, Yun Zhou, Ye Gong, Hechen Zhu, Wei Wang
Background. HMGB1 acts as an important inflammatory mediator and is a potential therapeutic target for sepsis. Glycyrrhizin (GL), a natural triterpene glycoside derived from licorice, has been demonstrated to inhibit HMGB1 activity. The aim of this study is to explore how GL affects the HMGB1 signaling in sepsis. Methods. We used a CLP model of sepsis and in vitro LPS or HMGB1-treated NR8383 cells to examine the effects of GL on expression of HMGB1 and proinflammatory cytokines. Furthermore, we explored the effect of GL on interactions between HMGB1 and RAGE or TLR4 and the activations of NF-κB and MAPKs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28483637/phyllanthus-niruri-leaves-aqueous-extract-improves-kidney-functions-ameliorates-kidney-oxidative-stress-inflammation-fibrosis-and-apoptosis-and-enhances-kidney-cell-proliferation-in-adult-male-rats-with-diabetes-mellitus
#14
Nelli Giribabu, Kamarulzaman Karim, Eswar Kumar Kilari, Naguib Salleh
ETHNOPHARMACOLOGICAL RELEVANCE: Phylanthus niruri has been used to treat ailments related to the urogenital organs. In this study, this herb was hypothesized to help to ameliorate kidney disease in diabetes mellitus (DM). AIMS: To investigate P. niruri leaves aqueous extract (PN) effects on kidney functions, histopathological changes and levels of oxidative stress, inflammation, fibrosis, apoptosis and proliferation in DM. METHODS: PN was orally administered to streptozotocin-nicotinamide-induced male diabetic rats for 28 days...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28482155/targeting-the-receptor-for-advanced-glycation-endproducts-rage-a-medicinal-chemistry-perspective
#15
Salvatore Bongarzone, Vilius Savickas, Federico Luzi, Antony D Gee
The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane, immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of endogenous extracellular ligands and intracellular effectors. Ligand binding at the extracellular domain of RAGE initiates a complex intracellular signaling cascade, resulting in the production of reactive oxygen species (ROS), immunoinflammatory effects, cellular proliferation, or apoptosis with concomitant upregulation of RAGE itself...
May 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28481921/low-sodium-diet-induces-atherogenesis-regardless-of-lowering-blood-pressure-in-hypertensive-hyperlipidemic-mice
#16
Fernanda B Fusco, Diego J Gomes, Kely C S Bispo, Veronica P Toledo, Denise F Barbeiro, Vera L Capelozzi, Luzia N S Furukawa, Ana P P Velosa, Walcy R Teodoro, Joel C Heimann, Eder C R Quintao, Marisa Passarelli, Edna R Nakandakare, Sergio Catanozi
This study investigated the influence of sodium restriction and antihypertensive drugs on atherogenesis utilizing hypertensive (H) low-density lipoprotein-receptor knockout mice treated or not with losartan (Los) or hydralazine (Hyd) and fed low-sodium (LS) or normal-sodium (NS) chow. Despite reducing the blood pressure (BP) of H-LS mice, the LS diet caused arterial lipid infiltration due to increased plasma total cholesterol (TC) and triglycerides (TG). Los and Hyd reduced the BP of H-LS mice, and Los effectively prevented arterial injury, likely by reducing plasma TG and nonesterified fatty acids...
2017: PloS One
https://www.readbyqxmd.com/read/28474638/expression-of-the-receptor-for-advanced-glycation-end-products-in-acquired-reactive-perforating-collagenosis
#17
Gulsen Akoglu, Nuran Sungu, Eda Karaismailoglu, Akin Aktas
BACKGROUND: Acquired reactive perforating collagenosis (ARPC) is a rare skin disorder characterized by transepidermal elimination of dermal collagen. There is little data regarding the pathogenesis of ARPC. The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor that plays an important role in inflammatory responses and may be involved in the pathogenesis of ARPC. AIM: To explore the expression of RAGE in ARPC. METHODS: Paraffin-embedded punch biopsy specimens of 41 patients with ARPC and of 11 healthy controls with normal skin were obtained from the Department Of Pathology...
April 27, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28474284/damage-associated-molecular-patterns-in-the-pathogenesis-of-osteoarthritis-potentially-novel-therapeutic-targets
#18
REVIEW
John H Rosenberg, Vikrant Rai, Matthew F Dilisio, Devendra K Agrawal
Osteoarthritis (OA) is a chronic disease that degrades the joints and is often associated with increasing age and obesity. The two most common sites of OA in adults are the knee and hip joints. Increased mechanical stress on the joint from obesity can cause the articular cartilage to degrade and release damage-associated molecular patterns (DAMPs). These DAMPs are involved in various molecular pathways that interact with nuclear factor-kappa B and result in the transcription of inflammatory cytokines and activation of matrix metalloproteinases that progressively destroy cartilage...
May 4, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28470354/small-interfering-rna-targeting-receptor-for-advanced-glycation-end-products-protects-the-rats-from-multibacterial-sepsis
#19
X Zhao, Y N Liao, Q Huang
BACKGROUND: Sepsis is a major challenge in clinical medicine, and treatment options are limited. Recently, the receptor for advanced glycation end products (RAGE) appears to be an excellent target for new therapeutic agents. AIMS: The objective of this study is to investigate the effect of small interfering RNA (siRNA) targeting RAGE on the outcome of multibacterial sepsis induced by cecal ligation and puncture (CLP) in a rat model. METHODS: A vector-based RAGE-targeted siRNA expression system (Psilencer-siRNA) was constructed and injected into rats via the jugular vein catheter after CLP injury...
May 3, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28465704/huang-gan-formula-eliminates-the-oxidative-stress-effects-of-advanced-oxidation-protein-products-on-the-divergent-regulation-of-the-expression-of-ages-receptors-via-the-jak2-stat3-pathway
#20
Quanwen Deng, Can Bu, Liqian Mo, Bin Lv, Shaolian Song, Xiaoyan Xiao, Guo Dan, Xixiao Yang
Chronic kidney disease (CKD) has a high prevalence and low cure rate and represents a significant health issue. Oxidative stress is common in CKD due to metabolic disorders, inflammation, and impaired renal function changing normal proteins into advanced oxidation protein products (AOPPs). Huang Gan formula (HGF) is a new type of traditional Chinese herbal medicine. Although we previously investigated the protective effects of HGF against oxidative stress, the mechanism of HGF in CKD is still not fully understood...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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