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https://www.readbyqxmd.com/read/28927200/epidemiology-of-invasive-fungal-disease-in-children
#1
Zoi Dorothea Pana, Emmanuel Roilides, Adilia Warris, Andreas H Groll, Theoklis Zaoutis
Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the growing number of immunocompromised children at risk for IFD, this disease continues to be associated with significant morbidity and death and with increased financial burden to the health care system...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28925550/contemporary-concepts-in-carious-tissue-removal-a-review
#2
REVIEW
Falk Schwendicke
OBJECTIVES: Based on a changed understanding of the disease caries and its pathogenesis, strategies for carious tissue removal have changed, too. This review aims to summarize these changes and to provide clinical recommendations. OVERVIEW: Removing all carious dentin from a cavity is not needed any longer to manage caries or the carious lesion. Instead, the carious lesion should be treated in a way allowing to arrest its activity, while preserving sound tooth tissue and pulp vitality...
September 19, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28923988/contemporary-management-of-cardiogenic-shock-a-scientific-statement-from-the-american-heart-association
#3
REVIEW
Sean van Diepen, Jason N Katz, Nancy M Albert, Timothy D Henry, Alice K Jacobs, Navin K Kapur, Ahmet Kilic, Venu Menon, E Magnus Ohman, Nancy K Sweitzer, Holger Thiele, Jeffrey B Washam, Mauricio G Cohen
Cardiogenic shock is a high-acuity, potentially complex, and hemodynamically diverse state of end-organ hypoperfusion that is frequently associated with multisystem organ failure. Despite improving survival in recent years, patient morbidity and mortality remain high, and there are few evidence-based therapeutic interventions known to clearly improve patient outcomes. This scientific statement on cardiogenic shock summarizes the epidemiology, pathophysiology, causes, and outcomes of cardiogenic shock; reviews contemporary best medical, surgical, mechanical circulatory support, and palliative care practices; advocates for the development of regionalized systems of care; and outlines future research priorities...
September 18, 2017: Circulation
https://www.readbyqxmd.com/read/28923905/acute-coronary-syndromes-the-way-forward-from-mechanisms-to-precision-treatment
#4
REVIEW
Filippo Crea, Peter Libby
Well into the 21st century, we still triage acute myocardial infarction on the basis of the presence or absence of ST-segment elevation, a century-old technology. Meanwhile, we have learned a great deal about the pathophysiology and mechanisms of acute coronary syndromes (ACS) at the clinical, pathological, cellular, and molecular levels. Contemporary imaging studies have shed new light on the mechanisms of ACS. This review discusses these advances and their implications for clinical management of the ACS for the future...
September 19, 2017: Circulation
https://www.readbyqxmd.com/read/28923562/intralesional-injection-of-collagenase-clostridium-histolyticum-may-increase-the-risk-of-late-onset-penile-fracture
#5
REVIEW
Jonathan A Beilan, Jared J Wallen, Adam S Baumgarten, Kevin N Morgan, Justin L Parker, Rafael E Carrion
INTRODUCTION: The use of intralesional injection of collagenase Clostridium histolyticum (CCH) has become a valid treatment option in the management of Peyronie's disease (PD). Multiple studies have shown the drug's safety and efficacy. However, sparse literature exists on the utility of the injection protocol's 14-day "observation period," in which patients are instructed to abstain from all sexual activity. AIM: To summarize the contemporary literature and report on our series of patients treated with CCH in an effort to explore the effectiveness of the postinjection observation period...
September 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28923394/a-contemporary-phone-based-cardiac-coaching-program-evolution-and-cross-cultural-utility
#6
Peita Price, Mark Tacey, Voula Koufariotis, Daniela Stramandinoli, Ruth Vincent, Leeanne Grigg, Dominica Zentner
BACKGROUND: The Hospital Admission Risk Program (HARP) Cardiac Coach Program at Royal Melbourne Hospital has evolved to include a Greek and Italian service, developed in response to the diverse local community and supported by evidence that Culturally and Linguistically Diverse (CALD) groups both perceive health and respond to health care services and information, differently. This paper aims to evaluate if a phone-based cardiac coaching program can be adapted to the Greek and Italian populations using the English cohort as a comparator...
August 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28923223/an-update-on-randomized-clinical-trials-in-hepatocellular-carcinoma
#7
REVIEW
Hao-Wen Sim, Jennifer Knox, Laura A Dawson
Hepatocellular carcinoma is a common malignancy that typically occurs in the setting of comorbid liver disease. Optimal management is challenging, especially given the assortment of available treatment modalities. This article reviews the randomized clinical trials that have formed the basis of contemporary hepatocellular carcinoma management.
October 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28922967/contemporary-hiv-aids-research-insights-from-knowledge-management-theory
#8
Chris William Callaghan
Knowledge management as a field is concerned with the management of knowledge, including the management of knowledge in research processes. Knowledge management theory has the potential to support research into problems such as HIV, antibiotic resistance and others, particularly in terms of aspects of scientific research related to the contribution of social science. To date, however, these challenges remain with us, and theoretical contributions that can complement natural science efforts to eradicate these problems are needed...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
https://www.readbyqxmd.com/read/28921765/assessing-fire-impacts-on-the-carbon-stability-of-fire-tolerant-forests
#9
Lauren T Bennett, Matthew J Bruce, Josephine Machunter, Michele Kohout, Saravanan Jangammanaidu Krishnaraj, Cristina Aponte
The carbon stability of fire-tolerant forests is often assumed but less frequently assessed, limiting potential to anticipate threats to forest carbon posed by predicted increases in forest fire activity. Assessing the carbon stability of fire-tolerant forests requires multi-indicator approaches that recognise the myriad of ways that fires influence the carbon balance including combustion, deposition of pyrogenic material, and tree death, post-fire decomposition, recruitment, and growth. Five years after a large-scale wildfire in south-eastern Australia, we assessed the impacts of low- and high-severity wildfire, with and without prescribed fire (≤ 10 years before), on carbon stocks in multiple pools, and on carbon stability indicators (carbon stock percentages in live trees and in small trees, and carbon stocks in char and fuels) in fire-tolerant eucalypt forests...
September 16, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28918954/contemporary-management-of-vesicoureteral-reflux
#10
REVIEW
Perviz Hajiyev, Berk Burgu
CONTEXT: Vesicoureteral reflux (VUR) remains the most interesting topic of pediatric urology due to the dynamic nature of recent controversial publications. Starting from the need for a diagnosis to the necessity and effectiveness of treatment in preventing scars, VUR remains in the mist. Although recent strong evidence helped as fog lights in this blurriness, more data are required for achieving crystal clearance. This article aims to summarize and discuss the current state of the evidence regarding VUR management...
September 11, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28916581/optimising-impact-and-sustainability-a-qualitative-process-evaluation-of-a-complex-intervention-targeted-at-compassionate-care
#11
Jackie Bridges, Carl May, Alison Fuller, Peter Griffiths, Wendy Wigley, Lisa Gould, Hannah Barker, Paula Libberton
BACKGROUND: Despite concerns about the degree of compassion in contemporary healthcare, there is a dearth of evidence for health service managers about how to promote compassionate healthcare. This paper reports on the implementation of the Creating Learning Environments for Compassionate Care (CLECC) intervention by four hospital ward nursing teams. CLECC is a workplace educational intervention focused on developing sustainable leadership and work-team practices designed to support team relational capacity and compassionate care delivery...
September 15, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28912667/how-do-nurse-consultant-job-characteristics-impact-on-job-satisfaction-an-australian-quantitative-study
#12
Michelle Giles, Vicki Parker, Rebecca Mitchell, Jane Conway
BACKGROUND: There is a direct link between job satisfaction, nurses' job performance and improved patient outcomes. Understanding what job characteristics influence job satisfaction is vital if health organizations are to optimize individual employee satisfaction and performance. This is particularly necessary in the Nurse Consultant role, which is a multifaceted role that has evolved to meet the dynamic and changing needs of health services. This study aims to examine how job characteristics influence Nurse Consultant job satisfaction and identify differences across metropolitan and rural contexts...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28912188/modern-imaging-techniques-in-cardiomyopathies
#13
REVIEW
M Fuad Jan, A Jamil Tajik
Modern advanced imaging techniques have allowed increasingly more rigorous assessment of the cardiac structure and function of several types of cardiomyopathies. In contemporary cardiology practice, echocardiography and cardiac magnetic resonance imaging are widely used to provide a basic framework in the evaluation and management of cardiomyopathies. Echocardiography is the quintessential imaging technique owing to its unique ability to provide real-time images of the beating heart with good temporal resolution, combined with its noninvasive nature, cost-effectiveness, availability, and portability...
September 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28911238/talking-about-sunbed-tanning-in-online-discussion-forums-assertions-and-arguments
#14
Jennifer Taylor, Alexandra Lamont, Michael Murray
OBJECTIVE: There is increasing evidence of both health and appearance risks associated with sunbed use. At the same time, the sunbed industry promotes the benefits of using sunbeds, and the image of a tanned skin as attractive and healthy arguably remains embedded within contemporary western culture. These tensions are played out in everyday conversations, and this paper reports a study which explored how sunbed users manage them within online discussion forums. DESIGN: A total of 556 posts from 13 sunbed-related threads, taken from six different UK-based online forums, were analysed thematically followed by techniques from discourse analysis...
September 15, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28906537/the-changing-spectrum-of-rheumatic-mitral-regurgitation-in-soweto-south-africa
#15
Ruchika Meel, Ferande Peters, Elena Libhaber, Mohammed Rafique Essop
OBJECTIVES: To determine the clinical and echocardiographic characteristics of contemporary patients with rheumatic mitral regurgitation (MR) at Chris Hani Baragwanath Academic Hospital. METHODS: This prospective, cross-sectional study included 84 patients with isolated moderate or severe rheumatic MR who underwent clinical and echocardiographic assessment. RESULTS: Mean age of the patients was 44 ± 15.3 years (84% females). Acute rheumatic fever was rare...
July 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28906340/contemporary-approach-to-joint-hypermobility-and-related-disorders
#16
Marco Castori, Alan Hakim
PURPOSE OF REVIEW: Joint hypermobility is a common, although largely ignored physical sign. Joint hypermobility is often asymptomatic but may be a feature of an underlying genetic disorder with systemic manifestations. The present article presents a comprehensive approach to considering joint hypermobility and clinically related issues in children and adults. RECENT FINDINGS: Ehlers-Danlos syndrome (EDS) is an umbrella term for various Mendelian connective tissue disorders sharing joint hypermobility, skin hyperextensibility, and tissue fragility...
September 12, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28902070/contending-with-preplanned-death-questions-for-clinicians
#17
Joel Yager
BACKGROUND AND OBJECTIVES: The goal of this column is to assist readers in reflecting on their attitudes and responses toward clinical and nonclinical situations involving preplanned deaths by decisionally capable individuals. Such circumstances range from encountering individuals in one's personal and professional lives who desire and intend to end their lives under their own terms, to having such individuals request assistance with predeath and postdeath arrangements. METHODS: Attending to pertinent literature, this essay uses Socratic inquiry to question conventional assumptions and attitudes, push readers' thoughts beyond typical comfort zones, and consider alternative modes of responding to challenges posed by preplanned death...
September 8, 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28899734/anaesthetic-management-of-pregnant-patients-with-cardiac-implantable-electronic-devices-case-reports-and-review
#18
REVIEW
M M Salman, H I Kemp, M R Cauldwell, D P Dob, R Sutton
Heart disease is a leading cause of maternal mortality and morbidity. Pregnant women with structural, conduction or degenerative cardiac disease who require rhythm control or who are at high risk of sudden cardiac death may carry a cardiac implantable electronic device or may occasionally require the insertion of one during their pregnancy. These women are now encountered more frequently in clinical practice, and it is essential that a multidisciplinary approach, beginning from the early antenatal phase, be adopted in their counselling and management...
August 4, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28899480/variability-in-hemoglobin-levels-in-hemodialysis-patients-in-the-current-era-a-retrospective-cohort-study
#19
David T Gilbertson, Yan Hu, Yi Peng, Bradley J Maroni, James B Wetmore
BACKGROUND: Given regulatory and reimbursement changes in anemia management, we examined hemoglobin variability in a contemporary cohort of maintenance hemodialysis patients. MATERIALS AND METHODS: The study population included > 200,000 hemodialysis patients with Medicare parts A and B as primary payer on October 1, 2012. Based on 25th and 75th percentiles, monthly hemoglobin values were categorized as low, intermediate, or high. Six variability categories were created by patterns during the 6-month observation period...
September 7, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28893689/management-of-kpc-producing-klebsiella-pneumoniae-infections
#20
REVIEW
M Bassetti, D R Giacobbe, H Giamarellou, C Viscoli, G L Daikos, G Dimopoulos, F G De Rosa, E J Giamarellos-Bourboulis, G M Rossolini, E Righi, I Karaiskos, M Tumbarello, D P Nicolau, P L Viale, G Poulakou
BACKGROUND: Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas. AIMS: our aim was to provide practical suggestion for physicians dealing with the management of KPC-KP infections in critically ill patients, based on expert opinions. SOURCES: PubMed search for relevant publications related to the management of KPC-KP infections. CONTENTS: a panel of experts developed a list of 12 questions to be addressed...
September 9, 2017: Clinical Microbiology and Infection
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