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Dritan Hasa, Dario Voinovich, Beatrice Perissutti, Alois Bonifacio, Mario Grassi, Erica Franceschinis, Stefano Dall'Acqua, Manuela Speh, Janez Plavec, Sergio Invernizzi
Significant improvement of solubilization kinetics of poorly soluble vinpocetine was obtained through a mechanochemical activation process in presence of micronized crospovidone. Drug-to-polymer weight ratio and milling time variables resulted to have statistically significant impacts on the activation of the product. The complete amorphization was obtained in the coground with the highest crospovidone contents (>80% wt), milled for the longest time (180 min). An ad hoc software was then used to calculate the dimensions of the drug crystallites in the samples on the basis of the calorimetric data...
March 2011: Journal of Pharmaceutical Sciences
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