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https://www.readbyqxmd.com/read/15564289/the-ppar-gamma-pro12ala-polymorphism-and-risk-for-incident-sporadic-colorectal-adenomas
#1
Zhihong Gong, Dawen Xie, Zonglin Deng, Roberd M Bostick, Stephanie J Muga, Thomas G Hurley, James R Hebert
Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear hormone receptor superfamily initially shown to be a key regulator of fat cell differentiation, can inhibit cell growth and induce apoptosis in colon cell lines. There are heterozygous loss of function mutations in the gene encoding PPARgamma in tumors from approximately 10% of human colon cancer patients. A common structural polymorphism has been detected in the PPARgamma gene at codon 12 (Pro12Ala). We investigated the hypothesis that the PPARgamma Pro12Ala polymorphism is associated with colorectal adenoma risk in a recently concluded case-control study of incident sporadic colorectal adenomas (163 cases and 212 controls)...
March 2005: Carcinogenesis
https://www.readbyqxmd.com/read/12660379/organochlorine-compounds-and-concentrations-of-thyroid-stimulating-hormone-in-newborns
#2
N Ribas-Fitó, M Sala, E Cardo, C Mazón, M E De Muga, A Verdú, E Marco, J O Grimalt, J Sunyer
AIMS: To assess the association between prenatal exposure to organochlorine compounds and thyroid status in newborns from an area with high levels of hexachlorobenzene (HCB). METHODS: A total of 98 mother-infant pairs (83.1% of all children born during the period 1997-99 in a specific area polluted with HCB) were recruited. Levels of organochlorine compounds were measured in 70 cord serum samples. Concentrations of thyroid stimulating hormone (TSH) were measured in plasma of all newborns three days after birth...
April 2003: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/10754593/growth-hormone-for-optimization-of-refractory-heart-failure-treatment
#3
E A Bocchi, Z Massuda, G Guilherme, D Carrara, G Bellotti, A Mocelin, C R Rodrigues Sobrinho, J F Ramires
It has been reported that growth hormone may benefit selected patients with congestive heart failure. A 63-year-old man with refractory congestive heart failure waiting for heart transplantation, depending on intravenous drugs (dobutamine) and presenting with progressive worsening of the clinical status and cachexia, despite standard treatment, received growth hormone replacement (8 units per day) for optimization of congestive heart failure management. Increase in both serum growth hormone levels (from 0.3 to 0...
October 1999: Arquivos Brasileiros de Cardiologia
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