keyword
https://read.qxmd.com/read/38528563/prenatal-opioid-use-as-a-predictor-of-postpartum-suicide-attempts-among-reproductive-age-women-enrolled-in-oregon-medicaid
#1
JOURNAL ARTICLE
Jangho Yoon, Mandana Masoumirad, Linh N Bui, Patrick Richard, S Marie Harvey
BACKGROUND: The rates of suicide and opioid use disorder (OUD) among pregnant and postpartum women continue to increase. This research characterized OUD and suicide attempts among Medicaid-enrolled perinatal women and examined prenatal OUD diagnosis as a marker for postpartum suicide attempts. METHODS: Data from Oregon birth certificates, Medicaid eligibility and claims files, and hospital discharge records were linked and analyzed. The sample included Oregon Medicaid women aged 15-44 who became pregnant and gave live births between January 2008 and January 2016 (N = 61,481)...
March 25, 2024: BMC Women's Health
https://read.qxmd.com/read/38524188/prolonged-detection-of-urine-norfentanyl-in-individuals-enrolled-in-a-medication-for-opioid-use-disorder-in-pregnancy-and-postpartum-program-a-case-series
#2
JOURNAL ARTICLE
Miranda K Kiefer, Jamie Cowen, Katherine A Hinely, Kara M Rood
BACKGROUND: Although urine drug testing can have vast legal and social ramifications, its interpretation during pregnancy and after birth remains not well understood. Fentanyl metabolism is altered by an individual's genetics, history of opioid use, and liver function. However, little is known about the clearance of fentanyl or its primary metabolite, norfentanyl, in the peripartum period. OBJECTIVE: We sought to identify and describe cases of delayed urine norfentanyl clearance in the pregnancy and postpartum period within our institution...
May 2024: AJOG global reports
https://read.qxmd.com/read/38512125/pregnant-women-s-experiences-of-seeking-treatment-for-opioid-use
#3
JOURNAL ARTICLE
Kimberly Dion, Sandra Cardaropoli, Ria Deshpande, Jennifer Kovarik
PURPOSE: The purpose of this study was to describe women's experiences seeking treatment for opioid use disorder during pregnancy. STUDY DESIGN AND METHODS: This was an exploratory multi-method study to understand women's experiences seeking treatment for opioid use disorder during pregnancy using surveys and interviews. Women pregnant within the past 5 years while using opioids were recruited from a private Facebook group for mothers on medication for opioid use disorder...
March 21, 2024: MCN. the American Journal of Maternal Child Nursing
https://read.qxmd.com/read/38508963/a-narrative-review-of-the-literature-relevant-to-obstetric-anesthesiologists-the-2023-gerard-w-ostheimer-lecture
#4
REVIEW
P Sultan
UNLABELLED: This narrative review of the 2023 Gerard W. Ostheimer lecture presented at the Society for Obstetric Anesthesia and Perinatology 2023 annual meeting summarizes 2022 literature relevant to obstetric anesthesiologists. ANTENATAL STUDIES: Neonatal morbidity is reduced with antenatal maternal buprenorphine compared with methadone for treatment of opioid use disorder. Antenatal pregnancy allergy testing is safe and feasible. ANALGESIA AND ANESTHESIA STUDIES: Intrathecal (IT) 3% chloroprocaine for cervical cerclage results in faster sensory block resolution and discharge readiness compared with bupivacaine...
January 3, 2024: International Journal of Obstetric Anesthesia
https://read.qxmd.com/read/38503843/preconception-opioids-interact-with-mouse-strain-to-alter-morphine-withdrawal-in-the-next-generation
#5
JOURNAL ARTICLE
Anika Toorie, Claire Davidson Hall, Fair M Vassoler, Gary Peltz, Elizabeth M Byrnes
RATIONALE: Transgenerational effects of preconception morphine exposure in female rats have been reported which suggest that epigenetic modifications triggered by female opioid exposure, even when that exposure ends several weeks prior to pregnancy, has significant ramifications for their future offspring. OBJECTIVE: The current study compares two mouse strains with well-established genetic variation in their response to mu opioid receptor agonists, C57BL/6J (BL6) and 129S1/svlmJ (129) to determine whether genetic background modifies the impact of preconception opioid exposure...
March 19, 2024: Psychopharmacology
https://read.qxmd.com/read/38501738/simplified-processing-and-rapid-quantification-of-buprenorphine-norbuprenorphine-and-their-conjugated-metabolites-in-human-plasma-using-uplc-ms-ms-assessment-of-buprenorphine-exposure-during-opioid-use-disorder-treatment
#6
JOURNAL ARTICLE
Wenchen Zhao, Osama Y Alshogran, Hongfei Zhang, Anand Joshi, Elizabeth E Krans, Steve Caritis, Imam H Shaik, Raman Venkataramanan
Opioid use disorder (OUD) is a chronic neurobehavioral ailment and is prevalent in pregnancy. OUD is commonly treated with methadone or buprenorphine (BUP). Pregnancy is known to alter the pharmacokinetics of drugs and may lead to changes in drug exposure and response. A simple, specific, and sensitive analytical method for measuring the parent drug and its metabolites is valuable for assessing the impact of pregnancy on drug exposure. A new liquid chromatography-tandem mass spectrometric method that utilized a simple protein precipitation procedure for sample preparation and four deuterated internal standards for quantification was developed and validated for BUP and its major metabolites (norbuprenorphine [NBUP], buprenorphine-glucuronide [BUP-G], and norbuprenorphine-glucuronide [NBUP-G]) in human plasma...
April 2024: Journal of Mass Spectrometry: JMS
https://read.qxmd.com/read/38483393/telehealth-treatment-for-opioid-use-disorder-during-pregnancy
#7
JOURNAL ARTICLE
M Justin Coffey, Maxwell Weng, Cynthia Jimes, Shannon Brigham, Marlene C Lira
No abstract text is available yet for this article.
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38479161/factors-associated-with-receipt-of-medication-for-opioid-use-disorder-among-pregnant-individuals-entering-treatment-programs-in-the-u-s
#8
JOURNAL ARTICLE
Laura Curran, Jennifer Manuel
BACKGROUND: Opioid use disorder (OUD) among pregnant individuals in the U.S. has been on the rise, and carries significant health risks if left untreated. Despite the effectiveness of medication for opioid use disorder (MOUD), rates of treatment utilization remain low, and access varies by state. This study seeks to expand on what is known about the utilization of MOUD by estimating annual percentages of MOUD use among treatment admissions among pregnant individuals across all 50 states and U...
March 12, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38476879/multimodal-acute-pain-management-in-the-parturient-with-opioid-use-disorder-a-review
#9
REVIEW
Victor Koltenyuk, Ismat Mrad, Ian Choe, Mohamad Ibrahim Ayoub, Sangeeta Kumaraswami, Jeff L Xu
The opioid epidemic in the United States has led to an increasing number of pregnant patients with opioid use disorder (OUD) presenting to obstetric units. Caring for this complex patient population requires an interdisciplinary approach involving obstetricians, anesthesiologists, addiction medicine physicians, psychiatrists, and social workers. The management of acute pain in the parturient with OUD can be challenging due to several factors, including respiratory depression, opioid tolerance, and opioid-induced hyperalgesia...
2024: Journal of Pain Research
https://read.qxmd.com/read/38476027/a-population-based-time-series-analysis-of-opioid-agonist-treatment-dispensed-during-pregnancy
#10
JOURNAL ARTICLE
Rose A Schmidt, Karl Everett, Amaya Perez-Brumer, Carol Strike, Brian Rush, Tara Gomes
BACKGROUND AND AIMS: Identifying effective opioid treatment options during pregnancy is a high priority due to the growing prevalence of opioid use disorder across North America. We assessed the temporal impact of three population-level interventions on the use of opioid agonist treatment (OAT) during pregnancy in Ontario, Canada. DESIGN: This was a population-based time-series analysis to identify trends in the monthly prevalence of pregnant people dispensed methadone and buprenorphine...
March 13, 2024: Addiction
https://read.qxmd.com/read/38456564/intrauterine-exposure-to-maternal-opioid-maintenance-treatment-and-associated-risk-factors-may-impair-child-growth
#11
JOURNAL ARTICLE
Minna Kanervo, Liina Luoto, Sarimari Tupola, Eeva Nikkola, Hanna Kahila, Krista Rantakari
AIM: How maternal opioid maintenance treatment (OMT) affects children is under-researched. This population-based registry study investigated child growth and somatic health following intrauterine exposure to this treatment. METHODS: Children born between 1 March 2011 and 30 May 2021 to mothers who used buprenorphine, buprenorphine-naloxone, or methadone throughout their pregnancies were followed for 2 years at the Helsinki University Hospital, Finland. Appropriate statistical tests were used to compare the treatment groups...
March 8, 2024: Acta Paediatrica
https://read.qxmd.com/read/38435674/what-to-expect-with-pregnant-or-postpartum-prescribing-of-extended-release-buprenorphine-cam2038
#12
JOURNAL ARTICLE
Michelle R Lofwall, Jessica L Young, Zachary Hansen, Elisha M Wachman, Christine Wilder, Constance Guille, Jasmin E Charles, Lawrence Leeman, Jessica R Gray, T John Winhusen
Weekly and monthly CAM2038 (Brixadi® ) extended-release subcutaneous buprenorphine (XR bup) has been available in Europe and Australia for several years and was approved by the Food and Drug Administration in May 2023. Little is known about the clinical experience of patients and providers using this new medication during prenatal care. Two cases of pregnant persons with opioid use disorder receiving weekly XR bup in an ongoing randomized multi-site outpatient clinical trial are presented along with a brief review of the pharmacology and literature on XR bup formulations...
December 2023: Journal of Clinical Gynecology and Obstetrics
https://read.qxmd.com/read/38424347/pregnancy-rates-among-women-treated-with-medication-for-opioid-use-disorder
#13
JOURNAL ARTICLE
Jennifer K Bello, Kevin Y Xu, Joanne Salas, Bronwyn S Bedrick, Richard A Grucza
BACKGROUND: Treatment-seeking people with opioid use disorder (OUD) who are capable of pregnancy need accurate information about the potential impact of medication to treat OUD (MOUD) on fertility to make informed choices about treatment that are consistent with their reproductive wishes. There is a dearth of research on fertility associated with MOUD receipt in birthing people with OUD. OBJECTIVE: To estimate the association between treatment with MOUD and odds of conception among birthing people using national administrative claims...
February 29, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38408650/maternal-opioid-use-disorder-and-infant-mortality-in-wisconsin-united-states-2010-2018
#14
JOURNAL ARTICLE
David C Mallinson, Hsiang-Hui Daphne Kuo, Russell S Kirby, Yi Wang, Lawrence M Berger, Deborah B Ehrenthal
OBJECTIVE: Differences in infant health outcomes by maternal opioid use disorder (OUD) status is understudied. We measured the association between maternal OUD during pregnancy and infant mortality and investigated whether these associations differ by infant neonatal opioid withdrawal syndrome (NOWS) or maternal receipt of medication for OUD (MOUD) during pregnancy. METHODS: We sampled 204,543 Medicaid-paid births from Wisconsin, United States (2010-2018). The primary exposure was any maternal OUD during pregnancy...
February 24, 2024: Preventive Medicine
https://read.qxmd.com/read/38404001/babywearing-reduces-urges-to-use-substances-in-the-postpartum-period-among-mothers-with-ouds
#15
JOURNAL ARTICLE
Lela Rankin, Lisa M Grisham, Natasha Mendoza, Alicia Allen
OBJECTIVES: While pregnancy presents a strong motivation to seek and comply with Opioid Use Disorder (OUD) treatment, the risk for relapse during the postpartum period is high. The purpose of the present study was to examine the impact of babywearing while admitted to the NICU on urges to use substances within 9 months of childbirth. METHODS: Mothers with a history of OUD ( N  = 47, M age = 28.91, SD  = 5.14; 48.9% White, 19.1% Latinx) and their newborns were randomly assigned to the intervention (babywearing) or control (infant rocker) condition while admitted to a NICU...
February 25, 2024: Substance Use & Misuse
https://read.qxmd.com/read/38394684/epidemiology-studies-on-effects-of-lithium-salts-in-pregnancy-are-confounded-by-the-inability-to-control-for-other-potentially-teratogenic-factors
#16
JOURNAL ARTICLE
Carr J Smith, Victoria M Payne
INTRODUCTION: In bipolar women who took lithium during pregnancy, several epidemiology studies have reported small increases in a rare fetal cardiac defect termed Ebstein's anomaly. METHODS: Behavioral, environmental, and lifestyle-associated risk factors associated with bipolar disorder and health insurance status were determined from an Internet search. The search was conducted from October 1, 2023, through October 14, 2023. The search terms employed included the following: bipolar, bipolar disorder, mood disorders, pregnancy, congenital heart defects, Ebstein's anomaly, diabetes, hypertension, Medicaid, Medicaid patients, alcohol use, cigarette smoking, marijuana, cocaine, methamphetamine, narcotics, nutrition, diet, obesity, body mass index, environment, environmental exposures, poverty, socioeconomic status, divorce, unemployment, and income...
2024: Human & Experimental Toxicology
https://read.qxmd.com/read/38380272/county-level-neonatal-opioid-withdrawal-syndrome-rates-and-real-world-access-to-buprenorphine-during-pregnancy-an-audit-secret-shopper-study-in-missouri
#17
JOURNAL ARTICLE
Bronwyn S Bedrick, Caroline Cary, Carly O'Donnell, Christine Marx, Hayley Friedman, Ebony B Carter, Nandini Raghuraman, Molly J Stout, Benson S Ku, Kevin Y Xu, Jeannie C Kelly
BACKGROUND: Amid rising rates of neonatal opioid withdrawal syndrome (NOWS) worldwide and in many regions of the USA, we conducted an audit study ("secret shopper study") to evaluate the influence of county-level buprenorphine capacity and rurality on county-level NOWS rates. METHODS: In 2019, up to three phone calls were made to buprenorphine prescribers in the state of Missouri (USA). County-level buprenorphine capacity was defined as the number of clinicians (across all specialties) accepting pregnant people divided by the number of births...
March 2024: Drug Alcohol Depend Rep
https://read.qxmd.com/read/38372152/addressing-substance-use-disorder-in-a-hospital-prenatal-setting
#18
REVIEW
Laudy Burgos, Michelle Gelband
Pregnancy can be a time of joy and hope but, for birthing parents struggling with a substance use disorder (SUD), it can be challenging. Social stigma, shame, and the potential legal ramifications present barriers to individuals seeking the care they need. Marginalized groups, in particular, face challenges that put them at even greater risk for substance misuse. Substance use during pregnancy can further impair the individual's level of functioning, and it has also been associated with problems in the social, emotional, and cognitive development of their children...
February 19, 2024: Social Work in Health Care
https://read.qxmd.com/read/38370328/buprenorphine-induction-using-microdosing-for-the-management-of-opioid-use-disorder-in-pregnancy
#19
Neil B Patel, Barbara V Parilla
Background  Conventional buprenorphine inductions require patients to abstain from full agonist opioids until they experience mild-to-moderate opioid withdrawal. We described a successful buprenorphine induction case in a pregnant patient using microdosing, which avoided withdrawal symptoms. Case Presentation  The patient is a 29-year-old G2P1001 at 18 2/7 weeks of gestation, who desired a switch from methadone to buprenorphine to minimize neonatal opioid withdrawal syndrome (NOWS), which complicated her last pregnancy...
January 2024: American Journal of Perinatology Reports
https://read.qxmd.com/read/38369773/trends-in-maternal-opioid-use-statewide-differences-by-sociodemographic-characteristics-in-florida-from-2000-to-2019
#20
JOURNAL ARTICLE
Amanda L Elmore, Nansi S Boghossian, Alexander C McLain, Suzanne McDermott, Jason L Salemi
BACKGROUND: Maternal opioid use (MOU) remains a public health concern. Studies have demonstrated significant increases in MOU, but estimates using ICD-10-CM or stratified by sociodemographic variables are limited. OBJECTIVES: Using a statewide, population-based dataset of Florida resident deliveries from 2000 to 2019, we examined the trend of MOU by age, race/ethnicity, education level, and insurance. METHODS: Florida administrative data was used to conduct a retrospective cohort study...
February 18, 2024: Journal of Addictive Diseases
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