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https://www.readbyqxmd.com/read/28748891/study-of-chronic-kidney-disease-mineral-bone-disorders-in-newly-detected-advanced-renal-failure-patients-a-hospital-based-cross-sectional-study
#1
Praveen Kumar Etta, R K Sharma, Amit Gupta
We aim to evaluate the disturbances in mineral metabolism, abnormalities in bone mineral density (BMD), and extraskeletal calcification in newly detected, untreated predialysis stage 4 and 5 chronic kidney disease (CKD) patients at a tertiary care hospital in North India. This is cross-sectional observational study. A total of 95 (68 males, 27 females) newly detected patients underwent clinical evaluation, biochemical assessment [serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, creatinine, intact parathyroid hormone (iPTH), 25- hydroxyvitamin D (25(OH)D)], BMD measurement (at spine, hip, and forearm) by dual-energy X-ray absorptiometry (DXA), lateral abdominal radiograph [for abdominal aortic calcification (AAC)], skeletal survey (to look for any abnormality including fractures), and echocardiography [for any cardiac valvular calcification (CVC)]...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748387/costs-of-fragility-hip-fractures-globally-a-systematic-review-and-meta-regression-analysis
#2
REVIEW
S Williamson, F Landeiro, T McConnell, L Fulford-Smith, M K Javaid, A Judge, J Leal
Purpose This study was conducted in order to systematically review the costs of hip fractures globally and identify drivers of differences in costs. Methods A systematic review was conducted to identify studies reporting patient level fragility hip fracture costs between 1990 and 2015. We extracted data on the participants and costs from these studies. Cost data concerning the index hospitalisation were pooled, and a meta-regression was used to examine its potential drivers. We also pooled data on the first-year costs following hip fracture and considered healthcare, social care as well as other cost categories if reported by studies...
July 26, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28748386/effect-of-denosumab-on-trabecular-bone-score-in-postmenopausal-women-with-osteoporosis
#3
M R McClung, K Lippuner, M L Brandi, J R Zanchetta, H G Bone, R Chapurlat, D Hans, A Wang, C Zapalowski, C Libanati
Trabecular bone score (TBS) assesses bone quality in the lumbar spine using dual-energy X-ray absorptiometry (DXA) scans. In postmenopausal women with osteoporosis, denosumab significantly improved TBS independently of bone mineral density (BMD). This practical technique may have a role in managing patients with osteoporosis. INTRODUCTION: TBS, a gray-level texture index determined from lumbar spine DXA scans, correlates with bone microarchitecture and enhances assessment of vertebral fracture risk independently of BMD...
July 26, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28746028/the-kaiser-permanente-northern-california-enhanced-recovery-after-surgery-program-design-development-and-implementation
#4
Vincent X Liu, Efren Rosas, Judith C Hwang, Eric Cain, Anne Foss-Durant, Molly Clopp, Mengfei Huang, Alexander Mustille, Vivian M Reyes, Shirley S Paulson, Michelle Caughey, Stephen Parodi
Complications are common after surgery, highlighting the need for innovations that reduce postsurgical morbidity and mortality. In this report, we describe the design, development, and implementation of an Enhanced Recovery After Surgery program in the Kaiser Permanente Northern California integrated health care delivery system. This program was implemented and disseminated in 2014, targeting patients who underwent elective colorectal resection and those who underwent emergent hip fracture repair across 20 Medical Centers...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28745799/efficacy-of-femoral-nail-anti-rotation-of-helical-blade-in-unstable-intertrochanteric-fracture
#5
Y Guo, H-P Yang, Q-J Dou, X-B He, X-F Yang
OBJECTIVE: We analyzed the comparative efficacy and long-term prognosis with proximal femoral nail anti-rotation (PFNA) and dynamic hip screw (DHS) for the treatment of unstable intertrochanteric fractures, retrospectively. We determined the independent risk factors to guide subsequent surgery and improve the long-term quality of life. PATIENTS AND METHODS: We selected 165 patients suffering from unstable intertrochanteric fracture from January 2010 to January 2015 in our hospital, including 89 treated with PFNA and 76 with DHS surgery...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28745563/validity-of-routinely-collected-data-in-identifying-hip-fractures-at-a-major-tertiary-hospital-in-australia
#6
Lieu Thi Thuy Trinh, Helen Achat, Sze Ming Loh, Robert Pascoe, Hassan Assareh, Joanne Stubbs, Veth Guevarra
OBJECTIVES: To examine the validity of routinely collected data in identifying hip fractures (HFs) and to identify factors associated with incorrect coding. METHOD: In a prospective cohort study between January 2014 and June 2016, HFs were identified using physician diagnosis and diagnostic imaging and were recorded in a Registry. Records of HFs in the health information exchange (HIE) were identified using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification/Australian Classification of Health Interventions/Australian Coding Standards codes...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28744801/a-retrospective-comparison-between-delayed-and-early-hip-fracture-surgery-in-patients-taking-clopidogrel-same-total-bleeding-but-different-timing-of-blood-transfusion
#7
Claire Pailleret, Zakaria Ait Hamou, Nadia Rosencher, Charles-Marc Samama, Violaine Eyraud, François Chilot, Christophe Baillard
PURPOSE: Managing hip fracture surgery in patients taking clopidogrel is challenging. The optimal timing for surgery remains unclear. Early surgery in such patients potentially increases peri-operative bleeding, whereas delayed surgery has been shown to be associated with worse postoperative outcomes. The aim of this study was to investigate whether a delay to surgery affects total blood loss, bleeding kinetics, blood transfusion requirements, or post-operative outcomes. METHODS: A retrospective monocentric study including all hip fracture patients treated with clopidogrel between 2011 and 2016 (39 patients) was carried out...
July 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28743778/fracture-risk-associated-with-common-medications-used-in-treating-type-2-diabetes-mellitus
#8
Daniel Wolverton, Melissa M Blair
PURPOSE: Published data on the risk of bone fractures associated with medications used for the treatment of type 2 diabetes mellitus are summarized. SUMMARY: A systematic literature search identified 108 publications on controlled trials and 6 meta-analyses addressing the potential for fractures with the use of 7 commonly used antidiabetic classes: thiazolidinediones (TZDs), sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, biguanides, insulin, and sulfonylureas...
August 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28743315/tight-intra-operative-blood-pressure-control-versus-standard-care-for-patients-undergoing-hip-fracture-repair-hip-fracture-intervention-study-for-prevention-of-hypotension-hip-hop-trial-study-protocol-for-a-randomised-controlled-trial
#9
Iain Keith Moppett, Stuart White, Richard Griffiths, Donal Buggy
BACKGROUND: Hypotension during anaesthesia for hip fracture surgery is common. Recent data suggest that there is an association between the lowest intra-operative blood pressure and mortality, even when adjusted for co-morbidities. This is consistent with data derived from the wider surgical population, where magnitude and duration of hypotension are associated with mortality and peri-operative complications. However, there are no trial to data to support more aggressive blood pressure control...
July 25, 2017: Trials
https://www.readbyqxmd.com/read/28742855/decreases-in-heart-rate-variability-are-associated-with-postoperative-complications-in-hip-fracture-patients
#10
Gernot Ernst, Leiv Otto Watne, Frede Frihagen, Torgeir Bruun Wyller, Andreas Dominik, Morten Rostrup
BACKGROUND: To explore relevant associations between deviations in linear and nonlinear heart rate variability (HRV) scores, and short-term morbidity and mortality in patients undergoing hip-surgery after a fracture. METHODS: 165 patients with hip fractures being admitted for surgery at two hospitals were included in a prospective cohort study. A short-term ECG was recorded within 24 hours of arrival. 15 patients had to be excluded due to insufficient quality of the ECG recordings...
2017: PloS One
https://www.readbyqxmd.com/read/28742787/functional-outcomes-of-elderly-patients-with-nonoperatively-treated-acetabular-fractures-that-meet-operative-criteria
#11
Scott P Ryan, Theodore T Manson, Marcus F Sciadini, Jason W Nascone, Christopher T LeBrun, Renan C Castillo, Ragu Muppavarapu, Brian Schurko, Robert V O'Toole
OBJECTIVES: To report functional outcomes of displaced acetabular fractures treated nonoperatively in the geriatric patient population. DESIGN: Retrospective case series. SETTING: Two Level I trauma centers. PATIENTS: Twenty-seven patients age 60 years or older who sustained displaced acetabular fractures during an 11-year period. INTERVENTION: Nonoperative treatment. MAIN OUTCOME MEASUREMENTS: Primary outcome measurements were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and Short Form 8 (SF-8) scores...
July 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28741078/-analysis-of-2000-surgically-treated-proximal-femoral-fractures-multiple-variables-influence-mortality
#12
Franz Müller, Michael Galler, Tanja Kottmann, Michael Zellner, Christian Bäuml, Bernd Füchtmeier
BACKGROUND: Due to demographic change, more proximal femoral fractures can be expected in the future. However, accurate growth rates as well as follow-up research extending more than 1 year postsurgery are still lacking. MATERIALS AND METHODS: First, we defined inclusion and exclusion criteria for the retrospective cohort study. Based on these, we collected all surgical interventions conducted between 1 January 2006 and 31 December 2015. For a total of 2000 consecutive procedures, we retrieved and analysed a total of 12 variables influencing mortality...
July 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28740525/the-use-of-cholecalciferol-in-patients-with-hip-fracture
#13
Luisella Cianferotti, Simone Parri, Giorgio Gronchi, Roberto Civinini, Maria Luisa Brandi
INTRODUCTION: Major osteoporotic fractures are steadily increasing due to population aging. Programs of secondary prevention against refracture are essential to decrease morbidity and mortality and the cost for individuals and the society. Vitamin D supplementation and optimization of calcium intake are of a pivotal importance to start specific osteoporosis treatment and for its safety and efficacy. Cholecalciferol is the most widely employed drug for vitamin D supplementation. PURPOSE: Aim of this study was to assess the trends in the use of vitamin D supplements containing cholecalciferol in the population of hip fracture patients older than 65 years, resident in the region of Tuscany (Italy) in the years 2011-2015 and to describe vitamin D status in a subgroup of this individuals directly referred to a bone clinic for further evaluation after hip osteoporotic fracture...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740524/a-comparison-of-two-fixation-methods-for-femoral-trochanteric-fractures-a-new-generation-intramedullary-system-vs-sliding-hip-screw
#14
Christian Carulli, Federico Piacentini, Tommaso Paoli, Roberto Civinini, Massimo Innocenti
INTRODUCTION: Trochanteric fractures are frequent and generally associated with bone fragility. There is still debate on the best fixation device to treat stable or rather stable trochanteric fractures: we report our clinical and radiological results of fixation with Proximal Femoral Nail "antirotation" (PFNa) in a population of patients compared to a control group treated by Sliding Hip Screw (SHS). MATERIALS AND METHODS: A prospective study was conducted in 71 consecutive patients treated by PFNa (group A), and 69 by a SHS (group B), with a mean age of 81...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740521/new-quantitative-ultrasound-techniques-for-bone-analysis-at-the-distal-radius-in-hip-fracture-cases-differences-between-femoral-neck-and-trochanteric-fractures
#15
Motoyuki Horii, Hiroyoshi Fujiwara, Ryo Sakai, Koshiro Sawada, Yasuo Mikami, Syogo Toyama, Etsuko Ozaki, Nagato Kuriyama, Masao Kurokawa, Toshikazu Kubo
BACKGROUND: Ample evidence on etiological and pathological differences between femoral neck and trochanteric fracture cases suggests the possibility of individualized treatment. There are many issues related to areal bone mineral density and other quantitative computed tomography parameters of the proximal femur. Although osteoporosis is a systemic problem, little has been reported regarding differences in bone structural parameters, including bone mineral density, between them in regions other than the proximal femur...
January 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28740372/pharmacological-treatment-of-osteoporosis-in-the-oldest-old
#16
REVIEW
A Vandenbroucke, F P Luyten, J Flamaing, E Gielen
The incidence of osteoporotic fractures increases with age. Consequently, the global prevalence of osteoporotic fractures will increase with the aging of the population. In old age, osteoporosis is associated with a substantial burden in terms of morbidity and mortality. Nevertheless, osteoporosis in old age continues to be underdiagnosed and undertreated. This may, at least partly, be explained by the fact that evidence of the antifracture efficacy of osteoporosis treatments comes mainly from randomized controlled trials in postmenopausal women with a mean age of 70-75 years...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28739416/comparison-of-non-invasive-assessments-of-strength-of-the-proximal-femur
#17
Fjola Johannesdottir, Erica Thrall, John Muller, Tony M Keaveny, David L Kopperdahl, Mary L Bouxsein
It is not clear which non-invasive method is most effective for predicting strength of the proximal femur in those at highest risk of fracture. The primary aim of this study was to compare the abilities of dual energy X-ray absorptiometry (DXA)-derived aBMD, quantitative computed tomography (QCT)-derived density and volume measures, and finite element analysis (FEA)-estimated strength to predict femoral failure load. We also evaluated the contribution of cortical and trabecular bone measurements to proximal femur strength...
July 21, 2017: Bone
https://www.readbyqxmd.com/read/28737630/first-in-the-nation-one-unit-s-journey-to-achieving-fragility-fracture-certification
#18
Audry McDonald, Samantha Church, Laura Hixon, Linda Vo, Martha Sleutel
Osteoporosis is related to more than 2 million fractures and $19 billion in healthcare costs each year (). A fragility fracture (FF) is a low-energy fracture of the distal radius, proximal humerus, ankle, or proximal femur (hip) from minimal trauma such as a fall from a standing height. In addition to cost, FFs often result in the loss of independence and productivity (). In 2015, our orthopaedic unit received the first certification ever awarded for FFs. Fragility fracture certification is a new certification demonstrating that a healthcare facility complies with national patient care standards and uses evidence-based practice guidelines to deliver quality outcomes...
July 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28736795/identifying-characteristics-and-outcomes-that-are-associated-with-fall-related-fatalities-multi-year-retrospective-summary-of-fall-deaths-in-older-adults-from-2005-2012
#19
Sara M Deprey, Lynda Biedrzycki, Kristine Klenz
BACKGROUND: Fall-related deaths continue to be the leading cause of accidental deaths in the older adult (65+ year) population. However, many fall-related fatalities are unspecified and little is known about the fall characteristics and personal demographics at the time of the fall. Therefore, this report describes the characteristics, circumstances and injuries of falls that resulted in older adult deaths in one U.S. County and explores the variables associated with fatal injuries from falls...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28736126/outcomes-following-osteosynthesis-of-periprosthetic-hip-fractures-around-cemented-tapered-polished-stems
#20
S T Goudie, S Patil, J T Patton, J F Keating
We retrospectively reviewed outcomes of 79 patients with periprosthetic hip fractures around cemented tapered polished stem (CTPS) implants treated with osteosynthesis between January 1997 and July 2011. All patients underwent open reduction and fixation using a broad dynamic compression plate (DCP). Seventy two (91%) of fractures united. There were seven (9%) non-unions with failure of metal work, three (4%) as a result of infection and four (5%) due to mechanical failure. Significant subsidence (>5mm) of the implant was seen in seven (9%) of cases...
July 12, 2017: Injury
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