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polymer micelle

Sema Sevimli, Frances C Knight, Pavlo Gilchuk, Sebastian Joyce, John T Wilson
Vaccine design has undergone a shift towards the use of purified protein subunit vaccines, which offer increased safety and greater control over antigen specificity, but at the expense of immunogenicity. Here we report the development of a new polymer-based vaccine delivery platform engineered to enhance immunity through the co-delivery of protein antigens and the Toll-like receptor 7 (TLR7) agonist imiquimod (IMQ). Owing to the preferential solubility of IMQ in fatty acids, a series of block copolymer micelles with a fatty acid-mimetic core comprising lauryl methacrylate (LMA) and methacrylic acid (MAA), and a poly(ethylene glycol) methyl ether methacrylate (PEGMA) corona decorated with pyridyl disulfide ethyl methacrylate (PDSM) moieties for antigen conjugation were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization...
February 13, 2017: ACS Biomaterials Science & Engineering
Jaleh Varshosaz, Somayeh Taymouri, Mohsen Minaiyan, Fatemeh Rastegarnasab, Azar Baradaran
The aim of this study was to develop hydroxypropyl methyl cellulose (HPMC)/chitosan gel containing polymeric micelles loaded with simvastatin (Sim) and evaluates its wound healing properties in rats. An irregular full factorial design was employed to evaluate the effects of various formulation variables including polymer/drug ratio, hydration temperature, hydration time and organic solvent type on the physicochemical characteristics of pluronic F127-cholesterol nanomicelles prepared using the film hydration method...
October 18, 2017: Drug Development and Industrial Pharmacy
Divya Sharma, Jagdish Singh
The aim of this study was to synthesize and characterize fatty acid-grafted-chitosan (fatty acid-g-CS) polymer and their nanomicelles for using as carriers for gene delivery. CS was hydrophobically modified using saturated fatty acids of increasing fatty acyl chain length. Carbodiimide along with N-hydroxysuccinimide was used for coupling carboxyl group of fatty acids with amine groups of CS. Proton nuclear magnetic resonance and Fourier transform-infrared spectroscopy were used to quantify fatty acyl substitution onto CS backbone...
October 17, 2017: Bioconjugate Chemistry
Shudi Yang, Ying Wang, Zhaoxiang Ren, Mengtian Chen, Weiliang Chen, Xuenong Zhang
In this research, a charge-conversional polymer, poly-l-lysine-lipoic acid (PLL-LA), was prepared by dimethylmaleic anhydride (DA) modification and applied as a carrier with enhanced cell internalization and intracellular pH- and reduction-triggered doxorubicin (Dox) release. The surface charge of dimethylmaleic anhydride-poly-l-lysine-lipoic acid micelles (DA-PLL-LA) was negative at physiological pH and reversed to positive at the extracellular and intracellular pH of cancer cells. At tumor extracellular pH of 6...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Haojun Ma
In clinical therapy, the poor prognosis of hepatocellular carcinoma (HCC) is mainly attributed to the failure of chemotherapeutical agents to accumulate in tumor as well as lack of potency of tumor penetration. In this work, we developed actively tumor-targeting micelles with pH-sensitive linker as a novel nanocarrier for HCC therapy. These micelles comprised of biodegradable PEG-pAsp polymers, in which PTX can be covalently conjugated to pAsp via an acid-labile acetal bond to form pH-responsive structures...
October 9, 2017: Journal of Pharmaceutical Sciences
Roberto Donno, Arianna Gennari, Enrique Lallana, Julio M Rios De La Rosa, Richard d'Arcy, Kevin Treacher, Kathryn Hill, Marianne Ashford, Nicola Tirelli
We have employed microfluidics (cross-shaped chip) for the preparation of drug-loaded poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles. The polymer precipitates from an acetone solution upon its controlled laminar mixing (flow focusing) with an aqueous solution of a surfactant, allowing for an operator-independent, up-scalable and reproducible preparative process of nanoformulations. Firstly, using PEGylated surfactants we have compared batch and microfluidic processes, and showed the superior reproducibility of the latter and its strong dependency on the acetone/water ratio (flow rate ratio)...
October 7, 2017: International Journal of Pharmaceutics
Jinming Zhang, Yifeng Zheng, Xi Xie, Lan Wang, Ziren Su, Yitao Wang, Kam W Leong, Meiwan Chen
Although tumor-targeting nanovehicles for hepatocellular carcinoma (HCC) chemotherapy have attracted great research and clinic interest, the poor cancer penetration, inefficient cellular uptake, and slow intracellular drug release greatly compromise their therapeutic outcomes. In this work, a multifunctional mixed micellar system, consisting of glycyrrhetinic acid (GA) for specific liver-targeting, trans-activator of transcription (TAT) peptide for potent cell penetration, and pH-sensitive poly(β-amino ester) polymers for acidic-triggered drug release, was developed to provide HCC-targeting delivery and pH-triggered release of doxorubicin (DOX)...
October 10, 2017: Molecular Pharmaceutics
R Catarino Centeno, R A Bustamante-Rendón, J S Hernández-Fragoso, I Arroyo-Ordoñez, E Pérez, S J Alas, A Gama Goicochea
The interfacial tension between immiscible liquids is studied as a function of a model linear surfactant length and concentration using coarse-grained, dissipative particle dynamics numerical simulations. The adsorption isotherms obtained from the simulations are found to be in agreement with Langmuir's model. The reduction of the interfacial tension with increasing surfactant concentration is found to display some common characteristics for all the values of chain length modeled, with our predictions being in agreement with Szyszkowski's equation...
October 6, 2017: Journal of Molecular Modeling
Siew-Leng Loo, Winna Siti, Monisha Thiyagarajan, Jaume Torres, Rong Wang, Xiao Matthew Hu
Film rehydration method is commonly used for membrane protein (MP) reconstitution into block copolymer (BCP), but the lack of control in the rehydration step formed a heterogeneous population of proteopolymersomes that interferes with the characterization and performance of devices incorporating them. To improve the self-assembly of polymersomes with simultaneous MP reconstitution, the study reported herein aimed to understand the effects of different variants of the rehydration procedure on the MP reconstitution into BCP membranes...
October 6, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Yurong Gao, Guiying Li, Zaishuai Zhou, Lei Guo, Xunyong Liu
A well-defined double hydrophilic poly(β-cyclodextrin)-containing diblock copolymer PEG-b-PCD was synthesized by atom transfer radical polymerization (ATRP). Complex micelles with defined core-shell structure were formed based on the host-guest interactions between poly(β-cyclodextrin) block copolymer and benzimidazole modified poly(ε-caprolactone) (BM-PCL). The hydrophobic PCD/BM-PCL resided in the core of micelles, while the hydrophilic poly(ethylene glycol) (PEG) chains acted as the micelles shell. The micelles exhibited regular spheres with diameter of about 255nm...
September 22, 2017: Colloids and Surfaces. B, Biointerfaces
Yizhong Shen, Yidan Sun, Runqi Yan, Erquan Chen, Huan Wang, Deju Ye, Jing-Juan Xu, Hong-Yuan Chen
Semiconductor quantum dots (QDs) have served as superior optically active nanomaterials for molecular imaging and photodynamic therapy (PDT), but the low singlet oxygen ((1)O2) quantum yield and lack of tumor selectivity have limited their applications for tumor PDT in vivo. Here, we report the rational engineering of QDs into tumor-targeting hybrid nanoparticles through micelle-encapsulating a pre-assembled unique QD-Zn-porphyrin complex, a highly fluorescent organic photosensitizer rhodamine 6G (R6G), and a near-infrared fluorophore NIR775 with folic acid labeled phospholipid polymers...
December 2017: Biomaterials
Qing Yao, Jong Hoon Choi, Zhi Dai, Jiao Wang, Dongin Kim, Xing Tang, Lin Zhu
To improve tumor targetability and drug efficacy and decrease drug resistance of dasatinib (DSB), the multifunctional micellar nanoparticles that combined the matrix metalloproteinase 2 (MMP2)-sensitive tumor (site) targeting with folate receptor-mediated tumor (cell) targeting were developed. Two major functional polymers, polyethylene glycol (5000 Da) - MMP2-sensitive peptide - phosphoethanolamin (PEG5k-pp-PE) and folic acid - polyethylene glycol (2000 Da) - phosphoethanolamin (FA-PEG2k-PE), were synthesized to construct the dual-targeted micellar nanoparticles (MMP/FR micelles)...
September 29, 2017: ACS Applied Materials & Interfaces
Bijaideep Dutta, K C Barick, Gunjan Verma, V K Aswal, Inbar Freilich, Dganit Danino, B G Singh, K I Priyadarsini, P A Hassan
PEG coated vesicles are important vehicles for the passive targeting of anticancer drugs. With a view to prepare PEG decorated vesicles using co-assembly of block copolymers and lipids, here we investigated the microstructure of aggregates formed in mixtures comprising lipids (l-α-phosphatidylcholine) and block copolymers (Pluronic P123), in the polymer rich regime. DLS and SANS studies show that the structure of the aggregates can be tuned from micelles to rod-like micelles or vesicles by changing the lipid to polymer composition...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
Alex Travesset
I show that all phases reported experimentally in binary nanoparticle superlattices can be described as networks of disclinations in an ideal lattice of regular tetrahedra. A set of simple rules is provided to identify the different disclination types from the Voronoi construction, and it is shown that those disclinations completely screen the positive curvature of the ideal tetrahedral lattice. In this way, this study provides a generalization of the well-known Frank-Kasper phases to binary systems consisting of two types of particles, and with a more general type of disclinations, i...
September 15, 2017: Physical Review Letters
Ziyuan Song, Zhiyuan Han, Shixian Lv, Chongyi Chen, Li Chen, Lichen Yin, Jianjun Cheng
Synthetic polypeptides from the ring-opening polymerization of N-carboxyanhydrides (NCAs) are one of the most important biomaterials. The unique features of these synthetic polypeptides, including their chemical diversity of side chains and their ability to form secondary structures, enable their broad applications in the field of gene delivery, drug delivery, bio-imaging, tissue engineering, and antimicrobials. In this review article, we summarize the recent advances in the design of polypeptide-based supramolecular structures, including complexes with nucleic acids, micelles, vesicles, hybrid nanoparticles, and hydrogels...
September 25, 2017: Chemical Society Reviews
Shengcai Yang, Zhaohui Tang, Dawei Zhang, Mingxiao Deng, Xuesi Chen
A pH and redox dual-sensitive biodegradable polysaccharide, succinic acid-decorated dextran-g-phenylalanine ethyl ester-g-cysteine ethyl ester (Dex-SA-l-Phe-l-Cys), was synthesized to load doxorubicin hydrochloride (DOX·HCl). The DOX-loaded nanoparticles, which were prepared in aqueous solution and free of organic solvent, could spontaneously self-assemble into uniform sizes. When loading DOX·HCl, mercapto Dex-SA-l-Phe-l-Cys was oxidized into a crosslinked disulfide linkage to form pH and redox dual-sensitive nanoparticles (DOX-S-NPs)...
September 26, 2017: Biomaterials Science
Banu Bayram, Aykut Özgür, Lütfi Tutar, Yusuf Tutar
Targeting drugs or pharmaceutical compounds to tumor site increases cancer treatment efficiency and therapeutic outcome. Nanoparticles are unique delivery systems for site-targeting within an organism. Many novel technologies have been established in drug research and development area. Nanotechnology now offers nanometer size polymeric nanoparticles and these particles direct drugs to their targets, protect drugs against degradation, and release the drug in a controlled manner. Modification of nanoparticle surface by molecules leads to prolonged retention and accumulation in the target area of the organism...
June 7, 2017: Current Pharmaceutical Design
Benjamin L Micklavzina, Marjorie L Longo
Here we examine how the force on an atomic force microscope (AFM) tip varies as it approaches micellar surfactant films, and use this information to discern the film's surface structure and Young's modulus. Rows of wormlike hemimicelles were created at a graphite interface using 10 mM sodium dodecyl sulfate (SDS). We found that the repulsive force on a silicon nitride tip as it approached the surface was exponential, with a decay length of 2.0 ± 0.1 nm. The addition of Na2SO4 was found to cause a change in this behavior, with a clear split into two exponential regions at concentrations above 1 mM...
September 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Chikara Yoshida, Yusuke Uchida, Tomoki Ito, Taku Takami, Yoshihiko Murakami
Wound-dressing sheet biomaterials can cover wound sites and enhance wound healing. In this study, a detailed evaluation of the factors affecting both the PEG modification percentage (PMP) in poly(ethylene glycol) (PEG)-grafted chitosan synthesis and the gelation properties of PEG-grafted chitosan was presented for constructing our novel hybrid hydrogel sheet consisting of PEG-grafted chitosan (a gel-forming polymer) and a reactive polymeric micelle (a crosslinker). It was confirmed that various factors (i.e...
September 13, 2017: Materials
Li Qin, Lei Wu, Shanshan Jiang, Dandan Yang, Huiyang He, Fang Zhang, Peng Zhang
Doxorubicin, as an anthracycline, plays an important role in chemotherapy. But multidrug resistance tremendously retards the anticancer effect of doxorubicin and results in the failure of chemotherapy. Multifunctional micelles emerge as a valid strategy to load doxorubicin by physical encapsulation or chemical binding to be delivered to cancer cells against multidrug resistance. In this review, mechanism of multidrug resistance of doxorubicin is simply described. Multifunctional co-delivery micelles of doxorubicin and main multidrug resistance modulators have been summarized in detail...
September 13, 2017: Journal of Drug Targeting
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