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https://www.readbyqxmd.com/read/29458211/impact-of-formulation-excipients-on-the-thermal-mechanical-and-electrokinetic-properties-of-hydroxypropyl-methylcellulose-acetate-succinate-hpmcas
#1
Tanvi M Deshpande, Anisul Quadir, Sakae Obara, Stephen W Hoag
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has been widely used in amorphous solid dispersions and as an enteric coating polymer. Under aqueous coating conditions and at elevated coating temperatures, HPMCAS particles tend to aggregate and clog the spray-nozzle, hence interrupting the coating process. This research focused on how plasticizers and surfactants, excipients used for aqueous coating, affect the properties and stability of HPMCAS. This information would be useful in identifying suitable excipients for developing a stable HPMCAS aqueous enteric coating formulation...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29453558/inorganic-nanoparticles-in-diagnosis-and-treatment-of-breast-cancer
#2
REVIEW
Cristina Núñez, Sergio Vázquez Estévez, María Del Pilar Chantada
Nanoparticles are being actively developed for biomolecular profiling of cancer biomarkers, tumor imaging in vivo, and targeted drug delivery. These nanotechnology-based techniques can be applied widely in the management of different malignant diseases, such as breast cancer. Although the number of different types of nanoparticles is increasing rapidly, most can be classified into two major types: particles that contain organic molecules as a major building material (such as dendrimers, micelles, liposomes and carbon nanotubes, and other polymers); and those that use inorganic elements, usually metals, as a core...
February 16, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29447446/on-line-proteolysis-and-glycopeptide-enrichment-with-thermo-responsive-porous-polymer-membrane-reactors-for-nanoflow-liquid-chromatography-tandem-mass-spectrometry
#3
Joon Seon Yang, Juan Qiao, Jin Yong Kim, Liping Zhao, Li Qi, Myeong Hee Moon
In this paper, we have reported a fully automated on-line method to carry out proteolysis and glycopeptide enrichment in sequence for nanoflow liquid chromatography-tandem mass spectrometry (nLC-ESI-MS/MS) analysis. By implementing two serial thermo-responsive porous polymer membrane reactors (TPPMRs), in which the TPPM could be immobilized either with trypsin for proteolysis or with lectins for glycopeptide enrichment, the entire pre-treatment procedure can be performed on-line in about an hour. The TPPM was fabricated by coating polystyrene-maleic anhydride-N-isopropylacrylamide (PS-MAn-PNIPAm), which was synthesized by reversible addition-fragmentation chain transfer polymerization, on a Nylon sheet...
February 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29445276/redox-responsive-f127-folate-f127-disulfide-bond-d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-p123-mixed-micelles-loaded-with-paclitaxel-for-the-reversal-of-multidrug-resistance-in-tumors
#4
Jing Lin, Chaoyue Zhao, Cuijuan Liu, Shiyao Fu, Luying Han, Xinping Lu, Chunrong Yang
Introduction: The development of nanodrug carriers utilizing tumor microenvironment has become a hotspot in reversing multidrug resistance (MDR). Materials and methods: This study synthesized a redox-sensitive copolymer, Pluronic F127-disulfide bond-d-α-tocopheryl polyethylene glycol 1000 succinate (FSST), through the connection of the reduction-sensitive disulfide bond between F127 and d-α-tocopheryl polyethylene glycol 1000 succinate. This polymer could induce the elevation of reactive oxygen species (ROS) levels, ultimately resulting in cytotoxicity...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29433939/targeted-mrna-therapy-for-ornithine-transcarbamylase-deficiency
#5
Mary G Prieve, Pierrot Harvie, Sean D Monahan, Debashish Roy, Allen G Li, Teri L Blevins, Amber E Paschal, Matt Waldheim, Eric C Bell, Anna Galperin, Jean-Rene Ella-Menye, Michael E Houston
We describe a novel, two-nanoparticle mRNA delivery system and show that it is highly effective as a means of intracellular enzyme replacement therapy (i-ERT) using a murine model of ornithine transcarbamylase deficiency (OTCD). Our Hybrid mRNA Technology delivery system (HMT) comprises an inert lipid nanoparticle that protects the mRNA from nucleases in the blood as it distributes to the liver and a polymer micelle that targets hepatocytes and triggers endosomal release of mRNA. This results in high-level synthesis of the desired protein specifically in the liver...
January 4, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29433753/a-glutathione-responsive-sulfur-dioxide-polymer-prodrug-as-a-nanocarrier-for-combating-drug-resistance-in-cancer-chemotherapy
#6
Wei Shen, Wanguo Liu, Huailin Yang, Peng Zhang, Chunsheng Xiao, Xuesi Chen
Multidrug resistance (MDR) in cancer remains a significant challenge for curing cancer by chemotherapy. In this work, a kind of glutathione (GSH)-responsive polymer prodrug of SO2 was designed and synthesized, which presented synergistic effect with doxorubicin (DOX) for combating MCF-7 ADR human breast cancer cell. Firstly, a small molecular prodrug of SO2, N-(3-azidopropyl)-2,4-dinitrobenzenesulfonamide (AP-DNs), was chemically conjugated onto the side chain of methoxy poly (ethylene glycol)-block-poly (γ-propargyl-l-glutamate) (mPEG-PPLG) block copolymer to generate an amphiphilic polymer prodrug of SO2, mPEG-PLG (DNs)...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29432695/single-step-in-situ-assembling-routes-for-the-shape-control-of-polymer-nanoparticles
#7
Nikunjkumar R Visaveliya, J Michael Köhler
Controlling shapes of polymer nanoparticles via single-step process is a challenge due to their amorphous chemical nature. Precise regulation of interfacial interactions, electrical charging and reaction dynamics during ongoing polymerization process provides an environment where uniform nucleation, growth and in-situ assembling can be realized, and hence nanoparticles of complex shapes can be obtained. In this work, it is investigated how in-situ assembling of the growing nanoparticles succeeds and specifically in different manners by using cationic, anionic, poly-ionic, and non-ionic surface-active agents in a time-dependent blended form...
February 12, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29430922/nanohydrogel-formation-within-halloysite-lumen-for-triggered-and-sustained-release
#8
Giuseppe Cavallaro, Giuseppe Lazzara, Stefana Milioto, Filippo Parisi, Vladimir G Evtugyn, Elvira Rozhina, Rawil F Fakhrullin
An easy strategy to obtain nanohydrogel within the halloysite nanotubes (HNTs) lumen was investigated. Inorganic reverse micelles based on HNTs and hexadecyltrimethylammonium bromides were dispersed in chloroform and the hydrophilic cavity was used as nano-reactor to confine the gel formation based on alginate cross-linked by calcium ions. Spectroscopy and electron microscopy experiments proved the confinement of the polymer into the HNTs lumen and the formation of calcium mediated networks. Biological tests proved the biocompatibility of the hybrid hydrogel...
February 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29429845/star-polymer-based-unimolecular-micelles-and-their-application-in-bio-imaging-and-diagnosis
#9
Xin Jin, Pei Sun, Gangsheng Tong, Xinyuan Zhu
As a novel kind of polymer with covalently linked core-shell structure, star polymers behave in nanostructure in aqueous medium at all concentration range, as unimolecular micelles at high dilution condition and multi-micelle aggregates in other situations. The unique morphologies endow star polymers with excellent stability and functions, making them a promising platform for bio-application. A variety of functions including imaging and therapeutics can be achieved through rational structure design of star polymers, and the existence of plentiful end-groups on shell offers the opportunity for further modification...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29426248/cholesterol-and-vitamin-e-conjugated-pegylated-polymeric-micelles-for-efficient-delivery-and-enhanced-anticancer-activity-of-curcumin-evaluation-in-2d-monolayers-and-3d-spheroids
#10
Omkara Swami Muddineti, Asmitha Vanaparthi, Sri Vishnu Kiran Rompicharla, Preeti Kumari, Balaram Ghosh, Swati Biswas
A newly synthesized PEGylated cholesterol/α-tocopheryl succinate (α-TOS) linked polymer (CV) was self-assembled and loaded with curcumin to form a micellar system (C-CVM). The tri-functionalized amphiphilic polymer was constituted of hydrophobic cholesterol and α-TOS connected to hydrophilic PEG via a lysine linker. The synthesized polymer and the micelles were characterized by 1 H NMR, DLS, zeta potentiometer, TEM, CMC determination and hemolysis studies. CVM displayed low CMC value of 15 µM with extent of hemolysis as less than 4%...
February 9, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29425184/bioreducible-polymer-micelles-based-on-acid-degradable-poly-ethylene-glycol-poly-amino-ketal-enhance-the-stromal-cell-derived-factor-1%C3%AE-gene-transfection-efficacy-and-therapeutic-angiogenesis-of-human-adipose-derived-stem-cells
#11
Tae-Jin Lee, Min Suk Shim, Taekyung Yu, Kyunghee Choi, Dong-Ik Kim, Soo-Hong Lee, Suk Ho Bhang
Adipose-derived stem cells (ADSCs) have the potential to treat ischemic diseases. In general, ADSCs facilitate angiogenesis by secreting various pro-angiogenic growth factors. However, transplanted ADSCs have a low therapeutic efficacy in ischemic tissues due to their poor engraftment and low viability. Stromal cell-derived factor-1α (SDF-1α) improves the survival rate of stem cells transplanted into ischemic regions. In this study, we developed acid-degradable poly(ethylene glycol)-poly(amino ketal) (PEG-PAK)-based micelles for efficient intracellular delivery of SDF-1α plasmid DNA...
February 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29424324/nano-medicine-as-a-newly-emerging-approach-to-combat-human-immunodeficiency-virus-hiv
#12
Muthupandian Saravanan, Tsehaye Asmalash, Atsebaha Gebrekidan, Dawit Gebreegziabiher, Tadele Araya, Haftamu Hilekiros, Hamed Barabadi, Kumaresan Ramanathan
BACKGROUND: Human Immuno deficiency Virus (HIV) infection has attained pandemic level due to its complexity on both the HIV infection cycle and on the targets for drug delivery. This limits medication and consequently requires prominent and promising drug delivery systems to be invented. Notably, various nanomaterial have been studied to enhance effective delivery of the antiretroviral drugs for HIV prevention, diagnosis and cure. Some of these nanomaterials are liposomes, dendrimers, inorganic nanoparticles (NPs), polymeric micelles, natural and synthetic polymers...
February 8, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29424314/pulmonary-delivery-of-triptorelin-loaded-in-pluronic-based-nanomicelles-in-rat-model
#13
Hamed Vakilzadeh, Jaleh Varshosaz, Mohsen Minaiyan
INTRODUCTION: Triptorelin the synthetic analog of gonadotrophin-releasing hormone is used for treatment of sex hormone dependent diseases via parenteral administration. The aim of the present study was investigation the possibility of triptorelin pulmonary delivery and preparation of a pulmonary nanocarrier delivery system for it. METHODS: Triptorelin was loaded in Pluronic-F127 grafted poly (methyl vinyl ether-alt-maleic acid) nanomicelles by direct dissolution method...
February 8, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29423496/real-time-monitoring-of-the-minute-dynamic-variation-at-the-crude-oil-water-interface
#14
Ming Duan, Ziling Ding, Hu Wang, Yan Xiong
Quantitative recording of the minute dynamic variation at an oil-water interface is always a great challenge. Dual polarization interferometry (DPI) presents an approach in monitoring the variations of mass, thickness, and density at the interface with high resolution. In this study, a planar crude oil-water interface was established by spin-coating on a DPI chip surface. Different concentrations of sodium dodecyl sulphate (SDS) and polyacrylamide (PAM) were injected into the interface. The absorption of free SDS molecules, in low concentrations, can be interpreted as a two-step absorption...
February 9, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29416334/copolymer-micelles-function-as-ph-responsive-nanocarriers-to-enhance-the-cytotoxicity-of-a-her2-aptamer-in-her2-positive-breast-cancer-cells
#15
Yinxing Shen, Junqi Zhang, Weiju Hao, Tong Wang, Jing Liu, Youhua Xie, Shouhong Xu, Honglai Liu
Efficient delivery of nucleic acids into target cells is crucial for nucleic acid-based therapies. Various nucleic acid delivery systems have been developed, each with its own advantages and limitations. We previously developed a nanoparticle-based delivery system for small chemical drugs using pH-responsive PEG8-PDPA100-PEG8 polymer micelles as carriers. In this study, we extend the application of these pH-responsive micelle-like nanoparticles (MNPs) to deliver oligonucleotides. We demonstrate that the MNPs efficiently encapsulate and deliver oligonucleotides of different lengths (20-100 nt) into cells...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29413458/long-term-biodistribution-study-of-hpma-ran-lma-copolymers-in-vivo-by-means-of-131i-labeling
#16
Karolin Wagener, Dorothea Moderegger, Mareli Allmeroth, Achim Reibel, Stefan Kramer, Barbara Biesalski, Nicole Bausbacher, Rudolf Zentel, Oliver Thews, Frank Rösch
BACKGROUND: For the evaluation of macromolecular drug delivery systems suitable pre-clinical monitoring of potential nanocarrier systems is needed. In this regard, both short-term as well as long-term in vivo tracking is crucial to understand structure-property relationships of polymer carrier systems and their resulting pharmacokinetic profile. Based on former studies revealing favorable in vivo characteristics for 18F-labeled random (ran) copolymers consisting of N-(2-hydroxypropyl)methacrylamide (HPMA) and lauryl methacrylate (LMA) - including prolonged plasma half-life as well as enhanced tumor accumulation - the presented work focuses on their long-term investigation in the living organism...
December 16, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29410626/hydrazone-containing-triblock-copolymeric-micelles-for-ph-controlled-drug-delivery
#17
Peilan Qi, Xiaohe Wu, Lei Liu, Huimin Yu, Shiyong Song
In this study, the structure-activity relationship of amphiphilic block copolymer micelles as nanosized drug delivery system was revealed. Firstly, a biodegradable triblock polymers PEG-DiHyd-PLA containing hydrazone bond was synthesized through the ring-opening polymerization. In this method, PEG-DiHyd-Phenol was used as the initiator and L-lactide as the monomer. Then, the polymeric micelles were formed and used as nano-drug carriers with pH sensitivity. The structure and composition of the polymer were characterized by infrared (IR), nuclear magnetic resonance (1H-NMR), and gel permeation chromatography (GPC), we characterized the self-assembling process of the triblock polymers and the pH sensitivity of the micelles by the means of transmission electron microscopy (TEM), dynamic light scattering method (DLS)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29405221/cylindrical-micelles-of-a-poss-amphiphilic-dendrimer-as-nano-reactors-for-polymerization
#18
Jing-Ting Weng, Tso-Fan Yeh, Ashok Zachariah Samuel, Yi-Fan Huang, Jyun-Hao Sie, Kuan-Yi Wu, Chi-How Peng, Hiro-O Hamaguchi, Chien-Lung Wang
A low generation amphiphilic dendrimer, POSS-AD, which has a POSS core and eight amphiphilic arms, was synthesized and used as a nano-reactor to produce well-defined polymer nano-cylinders. Confirmed by small-angle X-ray scattering (SAXS), Raman and NMR spectrometry, monodispersed cylindrical micelles that contain a hydrophilic cavity with a diameter of 2.09 nm and a length of 4.26 nm were produced via co-assembling POSS-AD with hydrophilic liquids, such as H2O and HEMA in hydrophobic solvents. Taking the HEMA/POSS-AD cylindrical micelles as nano-reactors, polymerization of HEMA within the micelles results in polymer nano-cylinders (POSS-ADNPs) with a diameter of 2...
February 6, 2018: Nanoscale
https://www.readbyqxmd.com/read/29402080/the-power-of-uplc-esi-ms-reconstructed-ion-chromatograms-in-the-characterization-of-small-differences-in-polymer-microstructure
#19
Ruben Epping, Ulrich Panne, Jana Falkenhagen
From simple homopolymers to functionalized, 3-dimensional structured copolymers, the complexity of polymeric materials has become more and more sophisticated. With new applications for instance in the semiconductor or pharmaceutical in-dustry, the requirements for the characterization have risen with the complexity of the used polymers. For each additional distribution, an additional dimension in analysis is needed. Small, often isomeric heterogeneities in topology or microstruc-ture can usually not be simply separated chromatographically or distinguished by any common detector, but affect the properties of materials significantly...
February 5, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29389087/space-sequence-disassembly-of-multicompartment-polymer-micelles-under-an-electrostatic-field-and-the-application-thereof-in-time-sequence-release
#20
Ming Wu, Yutian Zhu, Wei Jiang
Multicompartment micelles (MCPs), comprising sequences of repeated elemental discoid parts connected by fasciculus, were formed from self-assembly of polystyrene-block-poly(2-vinyl pyridine)-block-poly(ethylene oxide) (PS-b-P2VP-b-PEO) in selective solvent. Interestingly, under an electrostatic field, the MCPs can be disassembled from the outmost layer to intermediate layer, and then to inner layer of the aggregates through consequent departure of small spherical micelles (diameter: 90 nm). During this disassembly process, sequence release of loaded species from the micelles can be achieved...
February 1, 2018: Angewandte Chemie
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