keyword
MENU ▼
Read by QxMD icon Read
search

polymer micelle

keyword
https://www.readbyqxmd.com/read/28544958/impact-of-triblock-copolymers-on-the-biophysical-function-of-naturally-derived-lung-surfactant
#1
Moritz Beck-Broichsitter, Christian A Ruge, Adam Bohr
The current study aimed at investigating the general applicability of triblock copolymers consisting of poly(ethylene glycol) and poly(propylene glycol) (Pluronic(®)) as excipients for lung delivery. After thorough physicochemical characterization of the diverse polymers, their cytotoxicity was evaluated using alveolar epithelial cells. Next, a naturally-derived lung surfactant was challenged with the distinct triblock copolymers with respect to changes in microstructure, adsorption to the air/liquid interface and dynamic surface tension behavior under bubble pulsation...
May 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28541038/conical-ionic-amphiphiles-endowed-with-micellization-ability-but-lacking-air-and-oil-water-interfacial-activity
#2
Hirohisa Nitta, Koji Harano, Mayuko Isomura, Ellen H G Backus, Mischa Bonn, Eiichi Nakamura
Micellization in water and reduction of the surface tension of water interfaces with air and oil are two archetypical properties of surfactants, caused by self-aggregation and Gibbs monolayer formation at the interfaces, respectively. We present here a new type of amphiphiles that possess a conical shape consisting of a hydrophobic apex and five ionic termini at its base of the cone. The conical shape and the high charge density cooperatively impede the monolayer formation at the interfaces, and hence prevent foaming and emulsification...
May 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28537736/probing-the-cleaning-of-polymeric-coatings-by-nanostructured-fluids-a-qcm-d-study
#3
Martina Raudino, Nicoletta Giamblanco, Costanza Montis, Debora Berti, Giovanni Marletta, Piero Baglioni
Complex fluids composed of water, an organic solvent and a surfactant have been recently employed as cleaning systems to remove hydrophobic materials, such as polymeric coatings, from solid surfaces. The simultaneous presence of surfactants and an organic solvent with good affinity for the polymer was proven necessary for the polymer's removal, but the comprehension of the cleaning mechanism is poorly understood. In this article we investigated the mechanism of removal, highlighting the specific role of each component in the interaction with the polymer film...
May 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28532038/dynamic-covalent-linked-triblock-copolymer-micelles-for-glutathione-mediated-intracellular-drug-delivery
#4
Xueli Wang, Changyu He, Qinglai Yang, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Bing Gong, Yu-Mei Shen
Redox-responsive linkages dispersed in the backbones of the synthetic polymers, while young in the current spectrum of the biomedical application, are rapidly extending into their niche. In the present work, triblock copolymer PEG-PLA-PEG synthesized and characterized by (1)H -NMR and SEC can self-assemble into redox-responsive micelles in aqueous media with nanosized 33nm and 47nm. And the copolymers PEG2000-PLA3000-PEG2000 and PEG2000-PLA5000-PEG2000 present lower CMC with 0.034 and 0.022mg/mL, and higher DLC of 4...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531991/multifunctional-polymer-drug-loading-system-with-ph-sensitive-fluorescent-and-targeting-property
#5
Xuening Fei, Shubei Li, Lingyun Cao, Baolian Zhang, Miaozhuo Yu
IA multifunctional drug loading system with pH-sensitive, fluorescent and targeting property was fabricated. Firstly, the amphipathic N-octyl-N'-(2-carboxyl-cyclohexamethenyl) chitosan (OCCC) was prepared by grafting hydrophobic octyl group and hydrophilic hexahydrophthalic anhydride onto chitosan, then it was modified with folic acid (FA) and thiazole orange (TO) using polyethylene glycol (PEG) as the link to fabricate a multifunctional drug loading system TO-PEG-OCCC-PEG-FA. Its chemical structure was determined by Fourier transform infrared spectroscopy (FT-IR), elemental analysis, differential scanning calorimetry (DSC) analysis, UV-vis and fluorescence spectrometer, and the results showed that the substitution degree of hydrophobic/hydrophilic group onto chitosan were 41...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531980/self-assembled-nanomicelles-of-damnacanthal-loaded-amphiphilic-modified-chitosan-preparation-characterization-and-cytotoxicity-study
#6
Pakin Sukamporn, Seung Joon Baek, Wandee Gritsanapan, Suwabun Chirachanchai, Thararat Nualsanit, Pleumchitt Rojanapanthu
Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and (1)H NMR and the degree of substitution (DS) was determined by elemental analysis (EA)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529382/reversibly-manipulating-the-surface-chemistry-of-polymeric-nanostructures-via-a-grafting-to-approach-mediated-by-nucleobase-interactions
#7
Zan Hua, Robert Keogh, Zhen Li, Thomas R Wilks, Guosong Chen, Rachel K O'Reilly
"Grafting to" polymeric nanostructures or surfaces is a simple and versatile approach to achieve functionalization. Herein, we describe the formation of mixed polymer-grafted nanoparticles through a supramolecular "grafting to" method that exploits multiple hydrogen-bonding interactions between the thymine (T)-containing cores of preformed micelles and the complementary nucleobase adenine (A) of added diblock copolymers. To demonstrate this new "grafting to" approach, mixed-corona polymeric nanoparticles with different sizes were prepared by the addition of a series of complementary diblock copolymers containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) to a preformed micelle with a different coronal forming block, poly(4-acryloylmorpholine) (PNAM)...
May 9, 2017: Macromolecules
https://www.readbyqxmd.com/read/28524649/synthesis-and-stabilization-of-colloidal-perovskite-nanocrystals-by-multidentate-polymer-micelles
#8
Shaocong Hou, Yuzheng Guo, Yuguo Tang, Qimin Quan
Lead halide perovskites have emerged as low-cost, high-performance optical and optoelectronic materials, however, their material stability has been a limiting factor for broad applications. Here, we demonstrate stable core-shell colloidal perovskite nanocrystals using a novel, facile and low-cost co-polymer templated synthesis approach. The block co-polymer serves as a confined nano-reactor during perovskite crystallization and passivates the perovskite surface by forming a multidentate capping shell, thus significantly improving its photo-stability in polar solvents...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28520445/telodendrimers-for-physical-encapsulation-and-covalent-linking-of-individual-or-combined-therapeutics
#9
Ashok Kakkar, Jason Choi, Alexandre Moquin, Enzo Bomal, Li Na, Dusica Maysinger
New therapeutics for glioblastoma multiforme and our ability to deliver them using efficient nanocarriers, constitute topical areas of research. We report a comparative study of temozolomide and quercetin in the treatment of glioblastoma (GBM) in 3D, and their incorporation into micelles obtained from synthetically articulated architectural copolymers, and a commercially available linear polymer poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA). A versatile synthetic methodology to telodendrimers which can be easily adapted to the needs of other therapeutic interventions, is presented...
May 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28513597/thermophoretic-migration-of-vesicles-depends-on-mean-temperature-and-head-group-chemistry
#10
Emma L Talbot, Jurij Kotar, Lucia Parolini, Lorenzo Di Michele, Pietro Cicuta
A number of colloidal systems, including polymers, proteins, micelles and hard spheres, have been studied in thermal gradients to observe and characterize their driven motion. Here we show experimentally the thermophoretic behaviour of unilamellar lipid vesicles, finding that mobility depends on the mean local temperature of the suspension and on the structure of the exposed polar lipid head groups. By tuning the temperature, vesicles can be directed towards hot or cold, forming a highly concentrated region...
May 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28511687/polymeric-micelles-with-dual-thermal-and-reactive-oxygen-species-ros-responsiveness-for-inflammatory-cancer-cell-delivery
#11
Meiqiong Tang, Ping Hu, Qiang Zheng, Nicola Tirelli, Xiaohong Yang, Zhanlong Wang, Yanfang Wang, Qing Tang, Yun He
BACKGROUND: The object of this study was to develop a thermally and reactive oxygen species-responsive nanocarrier system for cancer therapy. RESULTS: PPS-PNIPAm block copolymer was designed and synthesised using a combination of living anionic ring-opening polymerization and atom transfer radical polymerization. The synthesized polymer formed micellar aggregates in water and demonstrated dual responsiveness towards temperature and oxidants. Using doxorubicin (DOX) as a model drug, encapsulation and in vitro release of the drug molecules in PPS-PNIPAm nanocarriers confirmed the responsive release properties of such system...
May 16, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28507933/novel-pentablock-copolymers-as-thermosensitive-self-assembling-micelles-for-ocular-drug-delivery
#12
REVIEW
Mitra Alami-Milani, Parvin Zakeri-Milani, Hadi Valizadeh, Roya Salehi, Sara Salatin, Ali Naderinia, Mitra Jelvehgari
Many studies have focused on how drugs are formulated in the sol state at room temperature leading to the formation of in situ gel at eye temperature to provide a controlled drug release. Stimuli-responsive block copolymer hydrogels possess several advantages including uncomplicated drug formulation and ease of application, no organic solvent, protective environment for drugs, site-specificity, prolonged and localized drug delivery, lower systemic toxicity, and capability to deliver both hydrophobic and hydrophilic drugs...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28505404/activated-porous-carbon-spheres-with-customized-mesopores-through-assembly-of-diblock-copolymers-for-electrochemical-capacitor
#13
Jing Tang, Jie Wang, Lok Kumar Shrestha, Md Shahriar A Hossain, Zeid Abdullah Alothman, Yusuke Yamauchi, Katsuhiko Ariga
A series of porous carbon spheres with precisely adjustable mesopores (4~16 nm), high specific surface area (SSA, ~2000 m2 g-1), and sub-micrometer particle size (~300 nm) have been synthesized through a facile co-assembly of diblock polymer micelles with a nontoxic dopamine source, and a common post-activation process. The mesopore size can be controlled by the diblock polymer, polystyrene-block-poly(ethylene oxide) (PS-b-PEO) templates and has an almost linear dependence on the square root of the degree of polymerization of the PS blocks...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28504884/d-%C3%AE-tocopheryl-succinate-phosphatidyl-ethanolamine-conjugated-amphiphilic-polymer-based-nanomicellar-system-for-the-efficient-delivery-of-curcumin-and-to-overcome-multiple-drug-resistance-in-cancer
#14
Omkara Swami Muddineti, Preeti Kumari, Balaram Ghosh, Vladimir P Torchilin, Swati Biswas
Nanomedicines have emerged as a promising treatment strategy for cancer. Multiple drug resistance due to overexpression of various drug efflux transporters and upregulation of apoptotic inhibitory pathways in cancer cells are major barriers that limit the success of chemotherapy. Here, we developed a d-α-tocopherol (α-TOS)/lipid-based copolymeric nanomicellar system (VPM) by conjugating phosphatidyl ethanolamine (PE) and α-TOS with poly(ethylene glycol) (PEG) via an amino acid linkage. The synthesized polymers were characterized by Fourier transform IR, gas-phase chromatography, and (1)H and (13)C NMR spectroscopy...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28504251/programmable-co-delivery-of-the-immune-checkpoint-inhibitor-nlg919-and-chemotherapeutic-doxorubicin-via-a-redox-responsive-immunostimulatory-polymeric-prodrug-carrier
#15
Jing-Jing Sun, Yi-Chao Chen, Yi-Xian Huang, Wen-Chen Zhao, Yan-Hua Liu, Raman Venkataramanan, Bin-Feng Lu, Song Li
To achieve synergistic therapeutic efficacy and prevent cancer relapse, chemotherapy and immunotherapy have been combined as a new modality for tumor treatment. In this work, we designed a redox-responsive immunostimulatory polymeric prodrug carrier, PSSN10, for programmable co-delivery of an immune checkpoint inhibitor NLG919 (NLG) and a chemotherapeutic doxorubicin (DOX). NLG-containing PSSN10 prodrug polymers were self-assembled into nano-sized micelles that served as a carrier to load DOX (DOX/PSSN10 micelles)...
May 8, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28501705/doxorubicin-delivered-by-a-redox-responsive-dasatinib-containing-polymeric-prodrug-carrier-for-combination-therapy
#16
Jingjing Sun, Yanhua Liu, Yichao Chen, Wenchen Zhao, Qianyu Zhai, Sanjay Rathod, Yixian Huang, Suoqin Tang, Yong Tae Kwon, Christian Fernandez, Raman Venkataramanan, Song Li
Two novel prodrug polymers POEG-b-PSSDas (redox-sensitive) and POEG-b-PCCDas (redox-insensitive), which consist of poly(oligo(ethylene glycol) methacrylate) (POEG) hydrophilic blocks and dasatinib (DAS, an oncogenic tyrosine kinases inhibitor) conjugated hydrophobic blocks, were designed as dual-functional carriers for codelivery with doxorubicin (DOX). Both carriers retained antitumor activity of DAS and could form mixed micelles with DOX. Compared to POEG-b-PCCDas micelles, incorporation of disulfide linkage into POEG-b-PSSDas micelles facilitated efficient cleavage of DAS from prodrug micelles in tumor cells/tissues, leading to a higher level of anti-tumor activity in vitro and in vivo...
May 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28496523/probing-the-causes-of-thermal-hysteresis-using-tunable-nagg-micelles-with-linear-and-brush-like-thermoresponsive-coronas
#17
L D Blackman, M I Gibson, R K O'Reilly
Self-assembled thermoresponsive polymers in aqueous solution have great potential as smart, switchable materials for use in biomedical applications. In recent years, attention has turned to the reversibility of these polymers' thermal transitions, which has led to debate over what factors influence discrepancies in the transition temperature when heating the system compared to the temperature obtained when cooling the system, known as the thermal hysteresis. Herein, we synthesize micelles with tunable aggregation numbers (Nagg) whose cores contain poly(n-butyl acrylate-co-N,N-dimethylacrylamide) (p(nBA-co-DMA)) and four different thermoresponsive corona blocks, namely poly(N-isopropylacrylamide) (pNIPAM), poly(N,N-diethylacrylamide) (pDEAm), poly(diethylene glycol monomethyl ether methacrylate) (pDEGMA) and poly(oligo(ethylene glycol) monomethyl ether methacrylate) (pOEGMA)...
January 1, 2017: Polymer Chemistry
https://www.readbyqxmd.com/read/28496063/fabrication-of-water-soluble-fluorescent-polymeric-micelles-for-selective-detection-of-hg-2-in-blood-serum
#18
Hong Wang, Jian Chen, Yongxiang Hong, Kun Lv, Maolin Yu, Peisheng Zhang, Yunfei Long, Pinggui Yi
In this study, amphiphilic diblock copolymers were designed and synthesized via the incorporation of reversible addition-fragmentation chain transfer radical polymerization (RAFT) and a subsequent grafting technique. Subsequently, Hg(2+)-sensitive water-soluble fluorescent polymeric micelles (FNs) were prepared by a reprecipitation strategy. The spectroscopic characteristics demonstrate that the fluorescein isothiocyanate (FITC) was successfully linked into the polymer. Due to the promoted reaction of desulfurization cyclization by Hg(2+), the fluorescence of fluorescein in FNs was obviously quenched...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28494698/extemporaneously-preparative-biodegradable-injectable-polymer-systems-exhibiting-temperature-responsive-irreversible-gelation
#19
Yasuyuki Yoshida, Kazuyuki Takata, Hiroki Takai, Keisuke Kawahara, Akinori Kuzuya, Yuichi Ohya
On clinical application of biodegradable injectable polymer (IP) systems, quick extemporaneous preparation of IP formulations and longer duration time gel state after injection into the body are the important targets to be developed. Previously, we had reported temperature-responsive covalent gelation systems via bio-orthogonal thiol-ene reaction by "mixing strategy" of amphiphilic biodegradable tri-block copolymer (tri-PCG) attaching acryloyl groups on both termini (tri-PCG-Acryl) with reactive polythiol. In other previous works, we found "freeze-dry with PEG/dispersion" method as quick extemporaneous preparation method of biodegradable IP formulations...
May 12, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28494408/solubilisation-of-oils-in-aqueous-solutions-of-a-random-cationic-copolymer
#20
Jonathan C Pegg, Adam Czajka, Gavin Hazell, Christopher Hill, Jocelyn Peach, Sarah E Rogers, Julian Eastoe
HYPOTHESIS: Reports of random copolymers capable of solubilising hydrophobic oils are rare. This is primarily because random copolymers are unlikely to self-assemble into suitable aggregates (or micelles) in water. A random copolymer with a "blocky" (or lumpy) microstructure may have potential to solubilise hydrophobic oils in water. This type of polymer would have advantages over block copolymers which are more laborious and costly to synthesise. EXPERIMENTS: The solubilising capacity of a blocky random copolymer, namely poly(methyl methacrylate-co-2-dimethylaminoethyl methacrylate) (PMMA-co-PDMAEMA) is assessed by UV-visible spectroscopy and compared with common reference surfactants...
May 2, 2017: Journal of Colloid and Interface Science
keyword
keyword
98624
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"