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https://www.readbyqxmd.com/read/29690765/miktoarm-amphiphilic-block-copolymer-with-singlet-oxygen-labile-stereospecific-%C3%AE-aminoacrylate-junction-synthesis-self-assembly-and-photodynamically-triggered-drug-release
#1
Gurusamy Saravanakumar, Hyeongmok Park, Jinhwan Kim, Dongsik Park, Swapan Pramanick, Dae Heon Kim, Won Jong Kim
Incorporation of a desired stimuli-responsive unit in a stereospecific manner at the specific location within a non-linear block copolymer architecture is a challenging task in synthetic polymer chemistry. Herein, we report a facile and versatile method to synthesize AB2 miktoarm block copolymers bearing a singlet oxygen (1O2)-labile regio and stereospecific -aminoacrylate linkage with 100% E-configuration at the junction via a combination of amino-yne click chemistry and ring opening polymerization. Using this strategy, a series of 1O2-responsive AB2 amphiphilic miktoarm copolymers composed of hydrophilic polyethylene glycol (PEG) as the A constituent and hydrophobic polycaprolactone (PCL) as the B constituent (MA-PEG-b-PCL2) was synthesized by varying the block length of PCL...
April 24, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29689288/self-assembled-amphiphilic-zein-lactoferrin-micelles-for-tumor-targeted-co-delivery-of-rapamycin-and-wogonin-to-breast-cancer
#2
Sally A Sabra, Ahmed O Elzoghby, Salah A Sheweita, Medhat Haroun, Maged W Helmy, Maha A Eldemellawy, Ying Xia, David Goodale, Alison L Allan, Sohrab Rohani
Protein-based micelles have shown significant potential for tumor-targeted delivery of anti-cancer drugs. In this light, self-assembled nanocarriers based on GRAS (Generally recognized as safe) amphiphilic protein co-polymers were synthesized via carbodiimide coupling reaction. The new nano-platform is composed of the following key components: i) hydrophobic zein core to encapsulate the hydrophobic drugs rapamycin (RAP) and wogonin (WOG) with high encapsulation efficiency, ii) hydrophilic lactoferrin (Lf) corona to enhance the tumor targeting, and prolong systemic circulation of the nanocarriers, and iii) glutaraldehyde (GLA)-crosslinking to reduce the particle size and improve micellar stability...
April 21, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29688912/tilianin-loaded-ros-scavenging-nano-micelles-protect-h9c2-cardiomyocyte-against-hypoxia-reoxygenation-induced-injury
#3
Yanfang Wang, Ying Wang, Xinchun Wang, Ping Hu
Previous studies have shown that Tilianin alleviates ischemia-reperfusion-induced cardiomyocyte injury. However, its clinical translation has been hampered because of its insolubility in water. Tilianin-based nano micelles that may overcome this critical issue are presented. A polyethylene glycol compound (PEG) was covalently attached to propylene sulfide formed amphiphilic diblock polymers. In the aqueous solution, tilianin is encapsulated in a hydrophobic shell to form nano micelles. The Ph-PPS-PEG self-assembled into nanoscale micelles with a size of approximately 70 nm, termed tilianin loaded micelles (TLMs)...
April 20, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29681154/controlled-self-assembly-of-multiple-responsive-superamphiphilc-polymers-based-on-host-guest-inclusions-of-a-modified-peg-with-%C3%AE-cyclodextrin
#4
Zhukang Du, Kang Ke, Xueyi Chang, Renfeng Dong, Biye Ren
Superamphiphilic polymers (SAPs) constructed by host-guest inclusion can self-assemble into various nanostructures in solution, which can find applications in many fields such as nanodevices, drug delivery and template synthesis. Herein, we report the controlled self-assembly of multiple-responsive SAP based on a selective host-guest inclusion of β-Cyclodextrin (β-CD) with a modified PEG (FcC11AzoPEG) consisting of a ferrocene (Fc) end group, a C11 alkyl chain, an azobenzene (Azo) block,and a polyethylene glycol (PEG) chain...
April 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29673646/polymeric-micelles-encapsulating-ph-responsive-doxorubicin-prodrug-and-glutathione-activated-zinc-ii-phthalocyanine-for-combined-chemotherapy-and-photodynamic-therapy
#5
Di Gao, Pui-Chi Lo
A series of polymeric micelles encapsulating different ratios of doxorubicin (DOX) and zinc(II) phthalocyanine (ZnPc) have been prepared for dual chemotherapy and photodynamic therapy (PDT). The amphiphilic block copolymers consist of methoxypolyethylene glycol (PEG) and poly(β-benzyl-l-aspartate) (PBLA), in which DOX and ZnPc were conjugated to the aspartate side chain through an acid-labile hydrazone linker and a redox-responsive disulfide linker, respectively. The polymers were self-assembled into spherical polymeric micelles with diameters of about 160-180 nm and their surface charges were found to be nearly neutral due to the outermost PEG layer...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29663921/multifunctional-hyaluronic-acid-decorated-redox-responsive-magnetic-complex-micelle-for-targeted-drug-delivery-with-enhanced-antitumor-efficiency-and-anti-cell-migration-activity
#6
Mangmang Sang, Zhongtao Zhang, Fulei Liu, Lejian Hu, Lingchao Li, Li Chen, Feng Feng, Wenyuan Liu, Wei Qu
A novel multifunctional hyaluronic acid-decorated redox-responsive magnetic complex micelle (HA/CSO-SS-Hex/Fe3O4/PTX) based on a reducible hexadecanol-modified chitosan oligosaccharide polymer micelle (CSO-SS-Hex) coated with hyaluronic acid (HA) and loaded with paclitaxel (PTX) Fe3O4 nanoparticles is developed. HA is coated onto the surface of micelles via electrostatic absorption and acts as a targeting ligand for CD44 over expression in many tumor cells. A CSO-SS-Hex polymer micelle was used for PTX incorporation and GSH-triggered intracellular release...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29655335/persistent-optical-hole-burning-spectroscopy-of-nano-confined-dye-molecules-in-liquid-at-room-temperature-spectral-narrowing-due-to-a-glassy-state-and-extraordinary-relaxation-in-a-nano-cage
#7
Hiroshi Murakami
Persistent optical hole-burning spectroscopy has been conducted for a dye molecule within a very small (∼1 nm) reverse micelle at room temperature. The spectra show a spectral narrowing due to site-selective excitation. This definitely demonstrates that the surroundings of the dye molecule are in a glassy state regardless of a solution at room temperature. On the other hand, the hole-burning spectra exhibit large shifts from excitation frequencies, and their positions are almost independent of excitation frequencies...
April 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29653223/acid-sensitive-hybrid-polymeric-micelles-containing-a-reversibly-activatable-cell-penetrating-peptide-for-tumor-specific-cytoplasm-targeting
#8
Baoqiang Tang, Jennica L Zaro, Yan Shen, Qian Chen, Yinglan Yu, Pingping Sun, Yanqi Wang, Wei-Chiang Shen, Jiasheng Tu, Chunmeng Sun
Cell-penetrating peptides (CPPs) have become a novel drug delivery system due to their distinct advantages, including high cell transmembrane potency and ability to carry cargo molecules inside cells. However, owing to their cationic charge and non-specificity characteristics, the clinical application of CPPs is limited. In the current study, we engineered a reversibly activatable cell-penetrating peptide (RACPP), containing oligoarginine fused to a pH-sensitive masking sequence via a polyglycine linker ((HE)10 G5 R6 or HE-CPP) with ultra-pH-sensitivity...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29652833/a-lipophilic-ir-780-dye-encapsulated-zwitterionic-polymer-lipid-micellar-nanoparticle-for-enhanced-photothermal-therapy-and-nir-based-fluorescence-imaging-in-a-cervical-tumor-mouse-model
#9
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652417/nanoparticle-packing-within-block-copolymer-micelles-prepared-by-the-interfacial-instability-method
#10
Gauri M Nabar, Jessica O Winter, Barbara E Wyslouzil
The interfacial instability method has emerged as a viable approach for encapsulating high concentrations of nanoparticles (NPs) within morphologically diverse micelles. In this method, transient interfacial instabilities at the surface of an emulsion droplet guide self-assembly of block co-polymers and NP encapsulants. Although used by many groups, there are no systematic investigations exploring the relationship between NP properties and micelle morphology. Here, the effect of quantum dot (QD) and superparamagnetic iron oxide NP (SPION) concentration on the shape, size, and surface deformation of initially spherical poly(styrene-b-ethylene oxide) (PS-b-PEO) micelles was examined...
April 13, 2018: Soft Matter
https://www.readbyqxmd.com/read/29645040/computational-studies-of-micellar-and-nanoparticle-nanomedicines
#11
Soumyo Sen, Yanxiao Han, Pavel Rehak, Lela Vuković, Petr Král
Nanomedicines are typically formed by nanocarriers which can deliver in a targeted manner drugs poorly soluble in blood, increase their therapeutic activities, and reduce their side effects. Many tested nanomedicines are formed by lipids, polymers, and other amphiphilic molecules isolated or self-assembled into various complexes and micelles, functionalized nanoparticles, and other bio-compatible composite materials. Here, we show how atomistic molecular dynamics simulations can be used to characterize and optimize the structure, stability, and activity of selected nanomedicines...
April 12, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29624828/polymeric-nanoparticles-with-glutathione-sensitive-heterodimeric-multifunctional-prodrug-for-in-vivo-drug-monitoring-and-synergistic-cancer-therapy
#12
Fuwu Zhang, Qianqian Ni, Orit Jacobson, Siyuan Cheng, Arthur Liao, Zhantong Wang, Zhimei He, Guocan Yu, Jibin Song, Ying Ma, Gang Niu, Longjiang Zhang, Guizhi Zhu, Xiaoyuan Chen
Polymeric micelle-based drug delivery systems have dramatically improved the delivery of small molecular drugs, yet multiple challenges remain to be overcome. In this work, we engineered a polymeric nanomedicine that possesses an ultrahigh loading (59%) of a glutathione (GSH)-sensitive heterodimeric multifunctional prodrug (HDMP) to effectively co-deliver two synergistic drugs to tumor. Specifically, an HDMP comprising of chemotherapeutic camptothecin (CPT) and photosensitizer 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-α (HPPH), was conjugated via a GSH-cleavable linkage...
April 6, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29621645/self-assembled-and-ph-sensitive-mixed-micelles-as-an-intracellular-doxorubicin-delivery-system
#13
Samira Jafarzadeh-Holagh, Sameereh Hashemi-Najafabadi, Hossein Shaki, Ebrahim Vasheghani-Farahani
Nanocarrier-based drug delivery systems have been explored extensively in cancer therapy. Among the vast number of different nanocarrier systems applied to deliver chemotherapeutics to cancer tumor, intelligent systems which deliver drug to various sites in the body have attracted considerable attentions. Finding a specific stimulant that triggers the carrier to release its payload in the target tissue is a key parameter for efficacy of delivery systems. Acidic pH of cancer tumor helps a pH-sensitive carrier to release drug at the tumor site...
March 1, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29620095/polymer-micro-nanocarrier-assisted-synergistic-chemohormonal-therapy-for-prostate-cancer
#14
Liang He, Weiguo Xu, Xiaoqing Wang, Chunxi Wang, Jianxun Ding, Xuesi Chen
Hormotherapy and chemotherapy are still the most important palliative therapeutic approaches for androgen-sensitive prostate cancer (PCa). Recently, the combination of hormotherapy and chemotherapy, namely, chemohormonal therapy has aroused considerable attention. Although synergistic chemohormonal therapy can improve PCa suppression efficacy and prolong the lives of patients, it also leads to severe adverse effects, that is, hormonal tolerance caused by hormotherapy, and leukemia or neutropenia caused by chemotherapy...
April 5, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29617144/undulated-gold-nanoplatelet-superstructures-in-situ-growth-of-hemispherical-gold-nanoparticles-onto-the-surface-of-gold-nanotriangles
#15
Ferenc Liebig, Radwan M Sarhan, Claudia Prietzel, Andreas F Thünemann, Matias Bargheer, Joachim Koetz
Negatively charged flat gold nanotriangles, formed in a vesicular template phase and separated by an AOT-micelle-based depletion flocculation, were reloaded by adding a cationic polyelectrolyte, that is, a hyperbranched polyethylenimine (PEI). Heating the system to 100 °C in the presence of a gold chloride solution, the reduction process leads to the formation of gold nanoparticles inside the polymer shell surrounding the nanoplatelets. The gold nanoparticle formation is investigated by UV-vis spectroscopy, small-angle X-ray scattering, and dynamic light scattering measurements in combination with transmission electron microscopy...
April 4, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29617063/folate-conjugated-polymeric-micelle-hb-loaded-on-targeting-effect-by-intraperitoneal-to-ovarian-cancer-in-vitro-and-in-vivo
#16
Jie Li, Shu Yao, Kai Wang, Zaijun Lu, Xuantao Su, Li Li, Cunzhong Yuan, Jinbo Feng, Shi Yan, Beihua Kong, Kun Song
Photodynamic therapy (PDT) is considered as an innovative and attractive modality to treat ovarian cancer. In this study, a biodegradable polymer poly (ethylene glycol)-poly (lactic acid)(PLA)-folate (FA-PEG-PLA) was prepared in order to synthesize an active targeting, water soluble and pharmacomodulated photosensitizer nano-carriers. The drug loading content, encapsulation efficiency, in vitro and in vivo release were characterized, in which HB/FA-PEG-PLA micelles had a high encapsulation efficiency and much slower control release for drugs compared to free drugs (p<0...
April 4, 2018: Cancer Science
https://www.readbyqxmd.com/read/29611567/axial-modification-inhibited-h-aggregation-of-phthalocyanines-in-polymeric-micelles-for-enhanced-pdt-efficacy
#17
Chen Jing, Ruolin Wang, Hanlin Ou, Ang Li, Yingli An, Shutao Guo, Linqi Shi
Axial modified phthalocyanine (BtPc), aiming at avoiding H-aggregation and utilizing long wavelength light, was designed and synthesized. With the aid of polymer nanotechnology, BtPc loaded polymeric micelles with strong singlet oxygen generating ability and enhanced photodynamic therapy efficiency were developed. Optical characterizations and in vitro evaluations proved that the BtPc loaded polymeric micelles hold great potential for photodynamic therapy.
April 3, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29608116/modified-mixed-nanomicelles-with-collagen-peptides-enhanced-oral-absorption-of-cucurbitacin-b-preparation-and-evaluation
#18
Lan Tang, Lulu Fu, Zhuanfeng Zhu, Yan Yang, Boxuan Sun, Weiguang Shan, Zhenhai Zhang
Polymer nanoparticles modified with collagen peptides (CPs) are an attractive strategy for the oral delivery of active ingredients from Chinese medicine. Thus, in the present study, collagen cationic CPs were simply separated using ion-exchange resin from bovine CPs, to modify mixed nanomicelles (MMs) on the surface to improve the oral bioavailability of Cucurbitacin B (CuB). The physicochemical property of micelles was characterized, which confirmed the successful modification of the nanomicelles. CPs-modified nanomicelles in vitro were found to significantly increase cellular uptake and transportation...
January 1, 2018: Drug Delivery
https://www.readbyqxmd.com/read/29607986/-development-of-noninvasive-drug-delivery-systems-to-the-brain-for-the-treatment-of-brain-central-nervous-system-diseases
#19
Takanori Kanazawa
 In general, the blood-brain barrier (BBB) poses a major challenge to drug development efforts targeting brain/central nervous system (CNS) diseases, since it limits the distribution of systemically administered therapeutics to the brain/ CNS. Therefore, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both the clinical and pharmaceutical fields. Intranasal administration has been noted as a method for noninvasive delivery of a drug to the brain/CNS by bypassing the BBB via the "nose-to-brain" route...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29604446/fabricating-highly-catalytically-active-block-copolymer-metal-nanoparticle-microstructures-at-the-liquid-liquid-interface
#20
Qi Diao, Xiaoyang Li, Mengxiao Diao, Yong-Ill Lee, Hong-Guo Liu
HYPOTHESIS: Our previous studies have shown that the metal nanoparticle/polymer composite structures fabricated at the liquid/liquid interface have good reusability but lower catalytic activity for heterogeneous reactions in aqueous solutions. This should be attributed to the poor water wettability and more compact structure of the polymer matrices. Therefore, it should be possible to improve the catalytic activity through designing and fabricating a porous composite structure with good water wettability...
March 22, 2018: Journal of Colloid and Interface Science
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