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polymer micelle

Guilaume Greyling, Harald Pasch
Charged block copolymer self-assemblies, such as charged micelles, have attracted much attention as versatile drug delivery systems due to their readily tunable characteristics such as size and surface charge. However, current column-based analytical techniques are not suitable to fractionate and comprehensively characterize charged micelles in terms of size, molar mass, chemical composition and morphology. Multidetector thermal field-flow fractionation (ThFFF) is shown to be a unique characterization platform that can be used to characterize charged micelles in terms of size, molar mass, chemical composition and morphology in aqueous mobile phases with various ionic strengths and pH...
December 5, 2017: Journal of Chromatography. A
Arpan Bhattacharya, Tushar Kanti Mukherjee
Understanding the fundamental electron transfer dynamics in photoactive carbon nanoparticles (CNPs) is utmost important for their fruitful application in photovoltaics and photocatalysis. Herein, photoinduced electron transfer (PET) to and from non-conjugated polymer nanodot (PND), a new class of luminescent CNP has been investigated in the presence of N, N-dimethylaniline (DMA) and methyl viologen (MV2+) in homogeneous methanol and sodium dodecyl sulfate (SDS) micelles. It has been observed that both, DMA and MV2+ interact with the photoexcited PND and quench the PL intensity as well as excited state lifetime in bulk methanol...
December 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Ilin Sadeghi, Jacob Kronenberg, Ayse Asatekin
Membranes that can separate compounds based on molecular properties can revolutionize the chemical and pharmaceutical industries. This study reports membranes capable of separating organic molecules of similar size based on their electrostatic charge. These membranes feature a network of carboxylate-functionalized 1-3 nm nanochannels, manufactured by a simple, scalable coating process: a porous support is coated with a packed array of polymer micelles in alcohol, formed by the self-assembly of a water-insoluble random copolymer with fluorinated and carboxyl functional repeat units...
December 5, 2017: ACS Nano
Ebrahim Shakiba, Saeedeh Khazaei, Marziyeh Hajialyani, Bandar Astinchap, Ali Fattahi
In order to achieve the controlled release of all-trans-retinoic acid (ATRA), poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) copolymer with average molecular weight of 5.34 kDa was synthesized. The nanosized micelles were prepared from copolymer by nano-precipitation method. Critical association concentration (CAC) of micelles was measured by fluorimetry and results indicated low CAC value of micelles (1.9 × 10-3 g/L). ATRA was encapsulated in the core of micelles using different ratios of drug to copolymer...
December 2017: Research in Pharmaceutical Sciences
Charlotte J C Edwards-Gayle, Francesca Greco, Ian W Hamley, Robert P Rambo, Mehedi Reza, Janne Ruokolainen, Dimitrios Skoulas, Hermis Iatrou
We investigate the self-assembly of two telechelic star polymer-peptide conjugates based on poly(ethylene oxide) (PEO) four-arm star polymers capped with oligotyrosine. The conjugates were prepared via N-carboxy anhydride (NCA)-mediated ring-opening polymerization from PEO star polymer macroinitiators. Self-assembly occurs above a critical aggregation concentration determined via fluorescence probe assays. Peptide conformation was examined using circular dichroism spectroscopy. The structure of self-assembled aggregates was probed using small-angle X-ray Scattering (SAXS) and cryogenic transmission electron microscopy (Cryo-TEM)...
December 1, 2017: Biomacromolecules
Yun Liu, Jan-Willem de Vries, Qing Liu, Alwin Hartman, Gerhard Wieland, Sebastian Wieczorek, Hans Boerner, Arno Wiehe, Eric Buhler, Marc Stuart, Wesley Browne, Andreas Herrmann, Anna Katharina Herta Hirsch
Hydrophobic drug candidates require innovative formulation agents. We designed and synthesized lipid-DNA polymers containing varying numbers of hydrophobic alkyl chains. The hydrophobicity of these amphiphiles is easily tunable by introducing a defined number of alkyl chain-modified nucleotides during standard solid-phase synthesis of DNA using an automated DNA synthesizer. We observed that the resulting self-assembled micelles solubilize the poorly water-soluble drug, meta-tetra-hydroxyphenyl-chlorin (mTHPC) used in photodynamic therapy (PDT) with high loading concentrations and loading capacities...
December 1, 2017: Chemistry: a European Journal
Bidisha Sarkar, Priyankar Paira
Theranostic agents or theranostic imaging as its name suggests is a combination of two terms-'diagnosis' & 'therapy'. Efforts are being made to combine both the terms into clinical formulations. This theranostic imaging is found to be very much significant to complex diseases like cancer and proliferative tumors specially now that protionic and genomic profiling can provide an accurate 'fingerprint' of each tumor, with all such kinds of informations theranostic agents can be designed in such a way that it is specific in its action and selective towards the cancer cells only, without causing any adverse effects on the normal tissue cells...
November 29, 2017: Mini Reviews in Medicinal Chemistry
Shunsuke Tanaka, Yusuf Valentino Kaneti, Ripon Bhattacharjee, Md Nazmul Islam, Rina Nakahata, Nawfel Abdullah, Shin-Ichi Yusa, Nam-Trung Nguyen, Muhammad J A Shiddiky, Md Shahriar A Hossain, Yusuke Yamauchi
Herein, we report the soft-templated preparation of mesoporous iron oxide using the asymmetric poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) triblock copolymer. To the best of our best knowledge, this block copolymer has not yet been used for the preparation of mesoporous iron oxide. This polymer forms a micelle consisting of a PS core, a PAA shell and a PEG corona in aqueous solutions, and the formed micelles can serve as templates. The mesoporous iron oxide obtained at an optimized calcination temperature of 400 °C exhibited an average pore diameter of 39 nm, with large specific surface area and pore volume of 86...
November 29, 2017: ACS Applied Materials & Interfaces
Ming Yuan, Shaojie Ding, Tingting Meng, Binbin Lu, Shihong Shao, Xinmei Zhang, Hong Yuan, Fuqiang Hu
Endometriosis is a common gynecological disease with a lack of effective clinical treatment. Current therapy often results in endometriosis pain recurrence and serious side effects. P2X3 receptor, an adenosine triphosphate (ATP)-gated ion channel, might be implicated in endometriosis pain. In this study, chitosan oligosaccharide-g-stearic acid (CSOSA) polymer micelles-coated nanostructured lipid carriers (NLCs) were developed as a novel delivery system for A-317491, a selective P2X3 receptor antagonist for endometriosis pain therapy...
2017: International Journal of Nanomedicine
Sovan Lal Banerjee, Nikhil K Singha
Amphiphilic diblock copolymers of poly(furfuryl methacrylate) (PFMA) with cationic poly(2-(methacryloyloxy)ethyltrimethyl ammonium chloride) (PFMA-b-PMTAC) and anionic poly(sodium 4-vinylbenzenesulfonate) (PFMA-b-PSS) were prepared via reversible addition fragmentation chain-transfer (RAFT) polymerization by using PFMA as a macro-RAFT agent. The formation of the block copolymer was confirmed by FTIR and 1H NMR analyses. In water, the amphiphilic diblock copolymers, (PFMA-b-PMTAC) and (PFMA-b-PSS), formed micelles with PFMA in the core and the rest of the hydrophilic polymers like PMTAC and PSS in the corona...
November 27, 2017: Soft Matter
Yuling Li, Li Baiyang, Bu Leran, Wang Zhen, Xie Yandong, Du Baixiang, Zhu Dandan, Zhu Yufu, Liang Jun, Yu Rutong, Liu Hongmei
A series of novel reduction-responsive micelles with tailored size were designed and prepared to release doxorubicin (DOX) for treating glioma, which were developed based on amphiphilic block copolymer poly (2-ethyl-2-oxazoline)-b-poly (ε-caprolactone) (PEtOz-SS-PCL) and the micelle size could be regulated by designing the polymer structure. The DOX-loaded PEtOz-SS-PCL micelles had small size and rapid drug release in reductive intracellular environments. Biodistribution and in vivo imaging studies in C6 glioma mice tumor model showed that DOX loaded PEtOz-SS-PCL43 micelles with the smallest size had superior accumulation and fast drug release in tumor sites...
November 2017: Drug Delivery
Changbong Yeon, Sun Jin Yun, Junjae Yang, Doo-Hyeb Youn, Jung Wook Lim
2D nanosheets of transition metal dichalcogenides (TMDCs) have been attracting attention due to their sizable band gap. Facile and effective Na-cation-assisted exfoliation of TMDC (MX2 , M = Mo, W; X = S, Se) nanosheets in an aqueous medium and their application as a composite filler in a polyvinyl alcohol (PVA) matrix are explored in this work. The presence of Na cations is highly beneficial for exfoliating defect-free and few-layer MX2 nanosheets in water in the presence of small-sized micelles of polymeric surfactant, and significantly elevates the exfoliation yield by more than one order of magnitude compared to a conventional surfactant-assisted exfoliation...
November 24, 2017: Small
Dan-Fei Chen, Yong-Qin Zhu, Yuan Zhang, Lin-Yan Wang, Ying-Hui Wei
This study was aimed to synthesize the polyethyleneglycol-polycaprolactone-polyethyleneimine (PEG-PCL-PEI) three block polymer material, prepareRhein (RH)-loaded PEG-PCL-PEI nanoparticles(PPP-RH-NPS), and then evaluate their physical and chemical properties and biological characteristics in vitro. PEG-PCL-PEI polymer was obtained by adopting thering-opening polymerization and Michael addition reaction, and their physical and chemical properties were analyzed by using NMR and gel permeation chromatography. PEG-PCL-PEI was then used as the carriers to prepare PPP-RH-NPS by applying spontaneous emulsification solvent diffusion method...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Hailu Yao, Shiyong Song, Xiaolu Miao, Xiao Liu, Zhen Wang, Xiaoting Shao, Yu Zhang, Guang Han
Many studies have shown that Andrographis paniculata (Burm. f.) Nees has a good anti-tumor effect, but poor solubility in water and poor bioavailability hinder the modernization of it. To formulate the effective parts (mainly diterpene lactones) of Andrographis paniculata (AEP) into targeting drug delivery system, a series of poly(ethylene glycol)-poly(D.L-lactic acid)(mPEG-PLA) with different ratio of hydrophilic and hydrophobic segment were synthetized to encapsulate AEP. AEP micelles were prepared by a simple solvent-evaporation method...
November 19, 2017: Current Drug Delivery
Mohsen Salmanpour, Ali Tamaddon, Gholamhossein Yousefi, Soliman Mohammadi-Samani
Introduction: Recent advances in the field of poly (2-oxazolines) as bio-inspired synthetic pseudopeptides have proven their potential biomedical applications such as drug delivery and tissue engineering. Methods: In order to fabricate a biodegradable micellar nanoparticle of poly (2-ethyl 2-oxazoline)-b-poly (benzyl L-glutamate) or pEOx-b-pBLG, "grafting-from" synthesis approach was used involving consecutive steps of cationic ring-opening polymerization of 2-ethyl-2-oxazoline, amine functionalization of pEOx using 1-Boc-piperazine and N-carboxyanhydride polymerization of γ-benzyl- L-glutamate...
2017: BioImpacts: BI
Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX and a siRNA, siAkt, directed at silencing the Akt expression. Methods: The pH-sensitive amphiphilic polymer, poly [(1,4-butanediol)-diacrylate-β-N, N-diisopropylethylenediamine]-polyethyleneimine (BDP) was synthesized...
2017: Theranostics
Peng-Wei Zhu, Luguang Chen
In this paper, we investigate the micelle (charge)-constrained collapse of a spherical poly(N-isopropylacrylamide) (PNIPAM) brush. The system is an example of the transition of a short-length neutral polymer from a stretched state to a folded state under the constraint of long-range electrostatic repulsion. The collapsed state is described as an anisotropic globule comprising a cascade of rod-like or hairpin bundles. A critical aggregation number of bound micelles is obtained to distinguish the charge-induced deformation of the globule, which provides a guideline to characterize globule dimensions under different strengths of electrostatic interaction...
November 20, 2017: Physical Chemistry Chemical Physics: PCCP
Min Gao, Jian Deng, Huiying Chu, Yu Tang, Zheng Wang, Yanjun Zhao, Guohui Li
Vitamin E (α-tocopherol) (TPGS) micelle is a robust nanocarrier in delivering hydrophobic active pharmaceutical ingredients, but is suffering from poor stability that is essential in terms of pharmaceutical and biomedical applications. Taking advantage of the chirality of vitamin E, this work reports the stereoselective stabilization of polymer-vitamin E conjugate micelles. Vitamin E was covalently linked to multivalent methoxy poly(ethylene glycol)-co-poly(glutamic acid), generating amphiphilic conjugates that could self-assemble into micelles...
November 17, 2017: Biomacromolecules
Vânia M P Vieira, Laura L Hay, David K Smith
This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component maintains its own unique functionality, demonstrating that multi-functionality can be achieved by simply mixing carefully-chosen constituents. Specifically, the individual components are: (i) pH-activated low-molecular-weight gelator (LMWG) 1,3;2,4-dibenzylidenesorbitol-4',4''-dicarboxylic acid (DBS-COOH), (ii) thermally-activated polymer gelator (PG) agarose, (iii) anionic biopolymer heparin, and (iv) cationic self-assembled multivalent (SAMul) micelles capable of binding heparin...
October 1, 2017: Chemical Science
Lucas R Parent, Evangelos Bakalis, Abelardo Ramírez-Hernández, Jacquelin K Kammeyer, Chiwoo Park, Juan de Pablo, Francesco Zerbetto, Joseph P Patterson, Nathan C Gianneschi
Amphiphilic small molecules and polymers form commonplace nanoscale macromolecular compartments and bilayers, and as such are truly essential components in all cells and in many cellular processes. The nature of these architectures, including their formation, phase changes, and stimuli-response behaviors, is necessary for the most basic functions of life, and over the past half-century, these natural micellar structures have inspired a vast diversity of industrial products, from biomedicines to detergents, lubricants, and coatings...
November 17, 2017: Journal of the American Chemical Society
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