keyword
MENU ▼
Read by QxMD icon Read
search

polymer micelle

keyword
https://www.readbyqxmd.com/read/28435248/redox-sensitive-pluronic-f127-tocopherol-micelles-synthesis-characterization-and-cytotoxicity-evaluation
#1
Yuling Liu, Sai Fu, Longfei Lin, Yuhong Cao, Xi Xie, Hua Yu, Meiwan Chen, Hui Li
Pluronic F127 (F127), an amphiphilic triblock copolymer, has been shown to have significant potential for drug delivery, as it is able to incorporate hydrophobic drugs and self-assemble into nanosize micelles. However, it suffers from dissociation upon dilution owing to the relatively high critical micelle concentration and lack of stimuli-responsive behavior. Here, we synthesized the α-tocopherol (TOC) modified F127 polymer (F127-SS-TOC) via a redox-sensitive disulfide bond between F127 and TOC, which formed stable micelles at relatively low critical micelle concentration and was sensitive to the intracellular redox environment...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28433941/self-assembled-dual-responsive-micelles-stabilized-with-protein-for-co-delivery-of-drug-and-sirna-in-cancer-therapy
#2
M R Aji Alex, Chetan Nehate, Srivani Veeranarayanan, D Sakthi Kumar, Ritu Kulshreshtha, Veena Koul
Design of safe and efficient vehicles for the combinatorial delivery of drugs and genetic agents is an emerging requisite for achieving enhanced therapeutic effect in cancer. Even though several nanoplatforms have been explored for the co-delivery of drugs and genetic materials the translation of these systems to clinical phase is still a challenge, mainly due to tedious synthesis procedures, lack of serum stability, inefficient scalability etc. Here in, we report development of reduction and pH sensitive polymeric graft of low molecular weight poly (styrene -alt -maleic anhydride) and evaluation of its efficacy in co-delivering drug and siRNA...
April 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28432913/spontaneously-formed-redox-and-ph-sensitive-polymersomes-by-mpeg-based-cytocompatible-random-copolymers
#3
Partha Laskar, Joykrishna Dey, Sudip Kumar Ghosh
Stimuli-sensitive polymersomes are one of the important vehicles and have been extensively studied as smart drug delivery system. Polymersomes have added advantage over the micelles because of having the ability to carry not only hydrophobic but also hydrophilic guest in their aqueous core. Among various stimuli, the change of pH and redox reaction is very important for drug delivery purpose especially for anticancer drug. Therefore, in this work, two poly(ethylene glycol) methyl ether methacrylate (mPEG) containing hydrophilic random anionic copolymers, poly[(2-hydroxyethyl methacrylate-3,3'-dithiodipropanoic acid)x-co-(poly(ethylene glycol) methyl ether methacrylate)y], poly[(HEMA-DTDPA)x-co-mPEGy] with different copolymer ratios were designed and synthesized...
April 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28428562/dehydroascorbic-acids-modified-polymer-micelles-target-cancer-cells-to-enhance-anti-tumor-efficacy-of-paclitaxel
#4
Xiaoyu Pei, Feifei Luo, Jun Zhang, Wulian Chen, Chen Jiang, Jie Liu
Paclitaxel (PTX), especially albumin-bound PTX in clinical, has displayed significant inhibition of tumor growth in patients. But the systemic distribution and poor water solubility of PTX often lead to severe side effects, consequently limiting the anti-tumor efficacy. In this study, we developed a novel PTX-loaded polymeric micelle drug delivery system. These self-assembled polymeric micelles from core to outside consisted of poly L-phenylalanine (pPhe), DTSSP linked poly L-lysine (pLys), poly ethylene glycol (PEG) and dehydroascorbic acids (DHA)...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28426951/temperature-induced-self-assembly-of-amino-acid-derived-vinyl-block-copolymers-via-dual-phase-transitions
#5
Nobuyuki Higashi, Daiki Sekine, Tomoyuki Koga
The unique thermoresponsive phase behaviors of diblock copolymers from amino acid-derived vinyl monomers have been demonstrated in view of variation in the aggregation state in water. Amino acid-based block copolymers composed of N-acryloyl-Ala-methylester (NAAMe) and N-acryloyl-βAla-methylester (NAβAMe) are successfully synthesized by RAFT polymerization. The resultant block copolymers poly(NAAMe48-b-NAβAMem) contain a constant degree of polymerization (DP=48) of the poly(NAAMe) block, but the DP of the poly(NAβAMe) block varies (m=80-122)...
April 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28426936/cholesterol-assisted-bacterial-cell-surface-engineering-for-photodynamic-inactivation-of-gram-positive-and-gram-negative-bacteria
#6
Hao-Ran Jia, Ya-Xuan Zhu, Zhan Chen, Fu-Gen Wu
Antibacterial photodynamic therapy (PDT) which enables effective killing of regular and multidrug-resistant (MDR) bacteria is a promising treatment modality for bacterial infection. However, because most photosensitizer (PS) molecules fail to strongly interact with the surface of Gram-negative bacteria, this technique is only suitable for treating Gram-positive bacterial infection, which largely hampers its practical applications. Herein, we revealed for the first time that cholesterol could significantly facilitate the hydrophobic binding of PSs to the bacterial surface, achieving the hydrophobic interaction-based bacterial cell surface engineering that could effectively photo-inactivate both Gram-negative and Gram-positive bacteria...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28423895/supramolecularly-engineered-%C3%AF-amphiphile
#7
Priya Rajdev, Saptarshi Chakraborty, Marc Schmutz, Philippe J Mésini, Suhrit Ghosh
This article describes self-assembly of supramolecularly engineered naphthalene-diimide (NDI) derived amphiphiles NDI-1 and NDI-2. They have the same hydrophobic/ hydrophilic balance but merely differ by a single functional group, amide or ester, respectively. They exhibit distinct self-assembly in water; NDI-1 form hydrogel which upon aging forms crystals while NDI-2 forms micelle as revealed by in-depth structural analysis using cryo-TEM, DLS and SAXS studies. These results suggest H-bonding among the amide groups fully regulates the self-assembly by overruling the packing parameters...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28420213/folate-decorated-nanomicelles-loaded-with-a-potent-curcumin-analogue-for-targeting-retinoblastoma
#8
Hashem Alsaab, Rami M Alzhrani, Prashant Kesharwani, Samaresh Sau, Sai Hs Boddu, Arun K Iyer
The aim of this study was to develop a novel folate receptor-targeted drug delivery system for retinoblastoma cells using a promising anticancer agent, curcumin-difluorinated (CDF), loaded in polymeric micelles. Folic acid was used as a targeting moiety to enhance the targeting and bioavailability of CDF. For this purpose, amphiphilic poly(styrene-co-maleic acid)-conjugated-folic acid (SMA-FA) was synthesized and utilized to improve the aqueous solubility of a highly hydrophobic, but very potent anticancer compound, CDF, and its targeted delivery to folate overexpressing cancers...
April 18, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28419458/therapeutic-potential-of-novel-formulated-forms-of-curcumin-in-the-treatment-of-breast-cancer-by-the-targeting-of-cellular-and-physiological-dysregulated-pathways
#9
REVIEW
Amir Tajbakhsh, Malihe Hasanzadeh, Mehdi Rezaee, Mostafa Khedri, Majid Khazaei, Soodabeh Shahid Sales, Gordon A Ferns, Seyed Mahdi Hassanian, Amir Avan
Breast cancer is among the most important causes of cancer related death in women. There is a need for novel agents for targeting key signaling pathways to either improve the efficacy of the current therapy, or reduce toxicity. There is some evidence that curcumin may have antitumor activity in breast cancer. Several clinical trials have investigated its activity in patients with breast cancer, including a recent trial in breast cancer patients receiving radiotherapy, in whom it was shown that curcumin reduced the severity of radiation dermatitis, although it is associated with low bioavailability...
April 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28416470/block-ionomer-micellar-nanoparticles-from-double-hydrophilic-copolymers-classifications-and-promises-for-delivery-of-cancer-chemotherapeutics
#10
REVIEW
S S Abolmaali, A M Tamaddon, M Salmanpour, S Mohammadi, R Dinarvand
A class of double hydrophilic copolymers comprising ionic and nonionic water-soluble blocks, which are also called block ionomers, represent an interesting type of polymer assembly forming stable, homogeneous core-corona dispersions. They exhibit the solution behavior of normal polyelectrolytes, whereas assembly into micelle, vesicle or disk morphology happens by an external stimulus (pH, temperature or ionic strength) or complex formation with metal ions, ionic surfactants, polyelectrolytes, etc. Temperature, pH, redox or salt sensitivity affords a unique opportunity to control the triggered release of payloads accommodated through electrostatic interaction, coordination or chemical conjugation...
April 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28415547/effect-of-polymer-degradation-on-prolonged-release-of-paclitaxel-from-filomicelles-of-polylactide-poly-ethylene-glycol-block-copolymers
#11
Katarzyna Jelonek, Suming Li, Janusz Kasperczyk, Xiaohan Wu, Arkadiusz Orchel
Paclitaxel is one of the most efficient anticancer agents, but the conventional dosage formulations cause many side effects. PLA-PEG filomicelles are promising carriers of paclitaxel because high loading capacity and long term release can be achieved. Slow release of cytostatic drugs is very advantageous due to prolonged exposure of tumor cells to cytostatic over multiple cell cycles. The aim of this study was to evaluate the potential of bioresorbable PLA-PEG filomicelles for prolonged delivery of paclitaxel...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28411641/nanoarmoring-of-proteins-by-conjugation-to-block-copolymer-micelles
#12
Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan
The creation of polymer nanoparticles with protein functionality is of great interest to many applications such as targeted drug or gene delivery, diagnostic imaging, cancer theranostics, delivery of protein therapeutics, sensing chemical and biomolecular analytes in complex environments, and design of protective clothing resembling a second skin. Many approaches to achieving this goal are being explored in the current literature. In this chapter, we describe a relatively simple and flexible approach of conjugating the protein to an amphiphilic block copolymer and creating polymer nanoparticles with protein functionality by taking advantage of the intrinsic self-assembly behavior of the amphiphilic block copolymer...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28407350/toroid-formation-through-a-supramolecular-cyclization-reaction-of-rodlike-micelles
#13
Chaoying Yang, Liang Gao, Jiaping Lin, Liquan Wang, Chunhua Cai, Yuhan Wei, Zhibo Li
Constructing polymeric toroids with a uniform, tunable size is challenging. Reported herein is the formation of uniform toroids from poly(γ-benzyl-l-glutamate)-graft-poly(ethylene glycol) (PBLG-g-PEG) graft copolymers by a two-step self-assembly process. In the first step, uniform rodlike micelles are prepared by dialyzing the polymer dissolved in tetrahydrofuran (THF)/N,N'-dimethylformamide (DMF) against water. With the addition of THF in the second step, the rodlike micelles curve and then close end-to-end to form uniform toroids, which resemble a cyclization reaction...
April 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28400314/peg-pe-clay-composite-carriers-for-doxorubicin-effect-of-composite-structure-on-release-cell-interaction-and-cytotoxicity
#14
Hagay Kohay, Can Sarisozen, Rupa Sawant, Aditi Jhaveri, Vladimir P Torchilin, Yael G Mishael
A novel drug delivery system for doxorubicin (DOX), based on organic-inorganic composites was developed. DOX was incorporated in micelles (M-DOX) of polyethylene glycol-phosphatidylethanolamine (PEG-PE) which in turn were adsorbed by the clay, montmorillonite (MMT). The nano-structures of the PEG-PE/MMT composites of LOW and HIGH polymer loadings were characterized by XRD, TGA, FTIR, size (DLS) and zeta measurements. These measurements suggest that for the LOW composite a single layer of polymer intercalates in the clay platelets and the polymer only partially covers the external surface, while for the HIGH composite two layers of polymer intercalate and a bilayer may form on the external surface...
April 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28398739/precipitate-coacervate-transformation-in-polyelectrolyte-mixed-micelle-systems
#15
Fatih Comert, Duy Nguyen, Marguerite Rushanan, Peker Milas, Amy Y Xu, Paul L Dubin
The polycation/anionic-nonionic mixed micelle, poly(diallyldimethylammonium chloride)-sodium dodecyl sulfate/Triton X-100 (PDADMAC-SDS/TX100), is a model polyelectrolyte-colloid system in that the micellar mole fraction of SDS (Y) controls the micelle surface charge density, thus modulating the polyelectrolyte-colloid interaction. The exquisite temperature dependence of this system provides an important additional variable, controlling both liquid-liquid (L-L) and liquid-solid (L-S) phase separation, both of which are driven by the entropy of small ion release...
April 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28397883/chemical-and-mechanical-modulation-of-polymeric-micelle-assembly
#16
Nicholas E Clay, Joseph J Whittenberg, Jiayu Leong, Vivek Kumar, Jinrong Chen, Insil Choi, Evangelos Liamas, Jeremy M Schieferstein, Jae Hyun Jeong, Dong Hyun Kim, Zhenyu Jason Zhang, Paul J A Kenis, Il Won Kim, Hyunjoon Kong
Recently, polymeric micelles self-assembled from amphiphilic polymers have been studied for various industrial and biomedical applications. This nanoparticle self-assembly typically occurs in a solvent-exchange process. In this process, the quality of the resulting particles is uncontrollably mediated by polymeric solubility and mixing conditions. Here, we hypothesized that improving the solubility of an amphiphilic polymer in an organic solvent via chemical modification while controlling the mixing rate of organic and aqueous phases would enhance control over particle morphology and size...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28394566/amphiphilic-arborescent-copolymers-and-microgels-from-unimolecular-micelles-in-a-selective-solvent-to-the-stable-monolayers-of-variable-density-and-nanostructure-at-a-liquid-interface
#17
Rustam A Gumerov, Andrey A Rudov, Walter Richtering, Martin Möller, Igor I Potemkin
Amphiphilic arborescent block copolymers of two generations (G2 and G3) and polymer microgels, obtained via cross-linking of diblock copolymers, were studied in a selective solvent and at liquid interface via dissipative particle dynamics (DPD) simulations. Depending on the primary structure, single arborescent macromolecules in selective solvent can have both core-corona and multicore structures. Self-assembly of the G2, G3, and microgels in the selective solvent is compared with equivalent linear diblock copolymers...
April 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28393688/nanoscale-functional-biomaterials-for-cancer-theranostics
#18
Linying Liu, Xiaoshuang Li, Lei Chen, Xin Zhang
Nanomedicine is widely developed in recent years. In nanomedicine system, nanoscale and nanostructured functional materials are used to manipulate the human biology systems at the molecular level for cancer imaging and therapy. New nanostructure based functional materials consist of nanoscale liposomes, spheres, micelles, capsules, emulsion, suspension and phamacosomes. Several functional nanoparticles such as lipid-based and polymer-based materials are demonstrated to be drug delivery vehicles and imaging agents...
April 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28378998/polyphosphoester-camptothecin-prodrug-with-reduction-response-prepared-via-michael-addition-polymerization-and-click-reaction
#19
Xueqiong Du, Yue Sun, Mingzu Zhang, Jinlin He, Peihong Ni
Polyphosphoesters (PPEs), as potential candidates for biocompatible and biodegradable polymers, play an important role in material science. Various synthetic methods have been employed in the preparation of PPEs such as polycondensation, polyaddition, ring-opening polymerization, and olefin metathesis polymerization. In this study, a series of linear PPEs has been prepared via one-step Michael addition polymerization. Subsequently, camptothecin (CPT) derivatives containing disulfide bonds and azido groups were linked onto the side chain of the PPE through Cu(I)-catalyzed azidealkyne cyclo-addition "click" chemistry to yield a reduction-responsive polymeric prodrug P(EAEP-PPA)-g-ss-CPT...
April 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28377319/development-of-extended-voyaging-anti-oxidant-linked-amphiphilic-polymeric-nanomicelles-for-anti-tuberculosis-drug-delivery
#20
Rajendran Amarnath Praphakar, Murugan A Munusamy, Mariappan Rajan
Amphiphilic chitosan-graft-poly(caprolactone)/(ferulic acid) (CS-g-PCL/FA) multi-co-polymers were fabricated by microwave-assisted ring opening polymerization followed by an 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide (EDC)-mediated coupling reaction and characterized by Fourier transformed infrared (FTIR) spectroscopy. Graft copolymers self-assembled into nanomicelles, and were able to incorporate rifampicin (RF) into their hydrophobic inner cores. X-ray diffraction (XRD) patterns were applied to characterize the crystal structures of graft polymers and the effects of RF on micelle morphology...
April 2, 2017: International Journal of Pharmaceutics
keyword
keyword
98624
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"