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https://www.readbyqxmd.com/read/28823025/nanomedicine-associated-with-photodynamic-therapy-for-glioblastoma-treatment
#1
REVIEW
Leonardo B de Paula, Fernando L Primo, Antonio C Tedesco
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most recurrent and malignant astrocytic glioma found in adults. Biologically, GBMs are highly aggressive tumors that often show diffuse infiltration of the brain parenchyma, making complete surgical resection difficult. GBM is not curable with surgery alone because tumor cells typically invade the surrounding brain, rendering complete resection unsafe. Consequently, present-day therapy for malignant glioma remains a great challenge. The location of the invasive tumor cells presents several barriers to therapeutic delivery...
August 19, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28809539/polymersomes-with-endosomal-ph-induced-vesicle-to-micelle-morphology-transition-and-a-potential-application-for-controlled-doxorubicin-delivery
#2
Turgay Yildirim, Anja Traeger, Pelin Sungur, Stephanie Hoeppener, Carolin Kellner, Ilknur Yildirim, David Pretzel, Stephanie Schubert, Ulrich S Schubert
A series of pH responsive block copolymers were synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization of 3,4-dihydro-2H-pyran (DHP) protected 2-hydroxyethyl methacrylate (HEMA) (2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl methacrylate (THP-HEMA)) and 2-(dimethylamino) ethyl methacrylate (DMAEMA) using p(THP-HEMA) as a macro chain transfer agent (mCTA). The degree of polymerization (DP) of the p(THP-HEMA) block was fixed to 35, whereas the DP of the p(DMAEMA) block was systematically varied from 21 to 50...
August 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28803471/altering-the-peptide-binding-selectivity-of-polymeric-reverse-micelle-assemblies-via-metal-ion-loading
#3
Meizhe Wang, Bo Zhao, Jingjing Gao, Huan He, Laura J Castellanos, Sankaran Thayumanavan, Richard W Vachet
Supramolecular reverse micelle assemblies, formed by amphiphilic copolymers, can selectively encapsulate molecules in their interiors depending on the functional groups present in the polymers. Altering the binding selectivity of these materials typically requires the synthesis of alternate functional groups. Here, we demonstrate that the addition of Zr(IV) ions into the interiors of reverse micelles having phosphonate functional groups transforms the supramolecular materials from ones that selectively bind positively-charged peptides into materials that selectively bind phosphorylated peptides...
August 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28802137/development-of-novel-polysulfone-membranes-with-embedded-zirconium-sulfate-surfactant-micelle-mesostructure-for-phosphate-recovery-from-water-through-membrane-filtration
#4
Kenji Furuya, Akira Hafuka, Miho Kuroiwa, Hisashi Satoh, Yoshimasa Watanabe, Hiroshi Yamamura
We prepared novel membranes that could adsorb phosphate from water through membrane filtration for use in a phosphate recovery system. Zirconium sulfate surfactant micelle mesostructure (ZS), which was the phosphate adsorbent, was embedded in a polysulfone matrix and flat sheet ultrafiltration membranes were made by nonsolvent induced phase separation. Scanning electron microscopy showed that the ZS particles existed on both the top surface and in the internal surface of the membrane. Increases in ZS content led to greater pure water flux because of increases in the surface porosity ratio...
August 5, 2017: Water Research
https://www.readbyqxmd.com/read/28800071/fabrication-and-characterization-of-magnesium-ferrite-based-pcl-aloe-vera-nanofibers
#5
Zanshe Thompson, Shekh Rahman, Sergey Yarmolenko, Jagannathan Sankar, Dhananjay Kumar, Narayan Bhattarai
Composite nanofibers of biopolymers and inorganic materials have been widely explored as tissue engineering scaffolds because of their superior structural, mechanical and biological properties. In this study, magnesium ferrite (Mg-ferrite) based composite nanofibers were synthesized using an electrospinning technique. Mg-ferrite nanoparticles were first synthesized using the reverse micelle method, and then blended in a mixture of polycaprolactone (PCL), a synthetic polymer, and Aloe vera, a natural polymer, to create magnetic nanofibers by electrospinning...
August 11, 2017: Materials
https://www.readbyqxmd.com/read/28797169/general-overview-of-lipid-polymer-hybrid-nanoparticles-dendrimers-micelles-liposomes-spongosomes-and-cubosomes
#6
Rajesh R Wakaskar
In recent years, the wider use of nanotechnology has attracted greater attention from scientists in multi-disciplinary fields. Nanotechnological research has come a long way in the past decade, with major advances being made, both in terms of diagnostic as well as therapeutic potential of nanoparticles. Areas covered: Some of the prominently discussed nanoparticles in this day and age are polymeric micelles, liposomes, lipid-polymer hybrid nanoparticles, dendrimers, spongosomes and cubosomes. This review attempts to focus on the conventional advantages and exemplary features that these particles possess, thus making them some of the most ideal vehicles for drug delivery...
August 10, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28794629/design-of-theranostic-nanomedicine-ii-synthesis-and-physicochemical-properties-of-a-biocompatible-polyphosphazene-docetaxel-conjugate
#7
Yong Joo Jun, Jung Hyun Park, Prakash G Avaji, Kyung Su Park, Kyung Eun Lee, Hwa Jeong Lee, Youn Soo Sohn
To prepare an efficient theranostic polyphosphazene-docetaxel (DTX) conjugate, a new drug delivery system was designed by grafting a multifunctional lysine ethylester (LysOEt) as a spacer group along with methoxy poly(ethylene glycol) (MPEG) to the polyphosphazene backbone ([NP]n), and then DTX was conjugated to the carrier polymer using acid-cleavable cis-aconitic acid (AA) as a linker. The resultant polyphosphazene-DTX conjugate, formulated as [NP(MPEG550)3(Lys-OEt)(AA)(DTX)]n and named "Polytaxel", exhibited high water solubility and stability by forming stable polymeric micelles as shown in its transmission electron microscopy image and dynamic light scattering measurements...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28782782/thermodynamic-stability-of-worm-like-micelle-solutions
#8
Karsten Vogtt, Gregory Beaucage, Michael Weaver, Hanqiu Jiang
Worm-like micelles (WLMs) are nano-scale self-assemblies widely used for viscosity enhancement, for drug delivery, and in personal care products. The stability of WLMs under variable ionic and surfactant concentrations is important to applications of these fascinating materials. In this work it is demonstrated that a virial approach can be used to understand and predict WLM stability. A mixed surfactant system consisting of sodium laureth sulfate and cocoamidopropyl betaine was examined using small-angle neutron scattering...
August 7, 2017: Soft Matter
https://www.readbyqxmd.com/read/28776980/amphiphilic-peptide-self-assembly-expansion-to-hybrid-materials
#9
Viktoria Mikhalevich, Ioana Craciun, Myrto Kyropoulou, Cornelia G Palivan, Wolfgang P Meier
The design of functional systems with sizes in the nanometer range is a key challenge in fields such as biomedicine, nanotechnology or engineering. Some of the most promising materials nowadays consist of self-assembling peptides or peptide-polymer hybrid materials because of the versatility, and the resulting properties, which can be achieved with these structures. Self-assembly of pure amphiphilic peptides or in combination with block copolymers results in a large variety of nanostructures (micelles, nanoparticles (NPs), compartments, planar membranes) each with different characteristics and tunable properties...
August 4, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28772418/spray-drying-to-get-spin-crossover-materials
#10
Nathalie Daro, Lucie Moulet, Nicolas Penin, Nicolas Paradis, Jean-François Létard, Eric Lebraud, Sonia Buffière, Guillaume Chastanet, Philippe Guionneau
Spin-crossover (SCO) triazole-based coordination polymers can be synthesized by micelle techniques, which almost always lead to rod-shaped nanoparticles. In order to notably reach new morphologies, we explore here the potentiality of the spray-drying (SD) method to get SCO materials. Three SCO coordination polymers and a mononuclear complex are investigated. In all cases, the SD method obtains particles definitely showing SCO. The features of the latter are yet always different from those of the referenced materials, in the sense that SCO is more gradual and incomplete, in adequacy with the poor crystallinity of the powders obtained by SD...
January 11, 2017: Materials
https://www.readbyqxmd.com/read/28767043/glutathione-responsive-micelles-incorporated-with-semiconducting-polymer-dots-and-doxorubicin-for-cancer-photothermal-chemotherapy
#11
Zhixiong Cai, Da Zhang, Xinyi Lin, Yunzhu Chen, Ming Wu, Zuwu Wei, Zhenxi Zhang, Xiaolong Liu, Cuiping Yao
Nanoplatform integrated with PTT and chemotherapy has been recognized a promising agent for enhancing cancer therapeutic outcomes, but still suffer from less controllability for optimizing their synergistic effects. Herein, we fabricated glutathione responsive micelles incorporated with semiconducting polymer dots and doxorubicin (referred as SPDOX NPs) for combining photothermal therapy (PTT) with chemotherapy to enhance cancer therapeutic efficiency. These micelles with excellent water dispersibility were comprised of three distinct functional components: (1) the monomethoxy-poly(ethylene glycol)-S-S-hexadecyl (mPEG-S-S-C16), which forms the micelles, can render hydrophobic substances water-soluble and improve the colloidal stability; (2) the disulfide linkages, can be cleaved in reductive environment for tumor-specific drug release due to the high GSH concentrations of tumor micro-environment; (3) Pdots and anticancer drug DOX that are loaded inside the hydrophobic core of the micelle can be applied to simultaneously perform PTT and chemotherapy to achieve significantly enhanced tumor killing efficiency both in vitro and in vivo...
August 2, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28766653/controllable-multicompartment-morphologies-from-cooperative-self-assembly-of-copolymer-copolymer-blends
#12
Zhikun Wang, Shuangqing Sun, Chunling Li, Songqing Hu, Roland Faller
Multicompartment nanostructures, such as microcapsules with clearly separated shell and core, are not easily accessible by conventional block copolymer self-assembly. We assess a versatile computational strategy through cooperative assembly of diblock copolymer blends to generate spherical and cylindrical compartmentalized micelles with intricate structures and morphologies. The co-assembly strategy combines the advantages of polymer blending and incompatibility-induced phase separation. Following this strategy, various nanoassemblies of pure AB, binary AB/AC and ternary AB/AC/AD systems such as compartmentalized micelles with sponge-like, Janus, capsule-like and onion-like morphologies can be obtained...
August 2, 2017: Soft Matter
https://www.readbyqxmd.com/read/28759235/block-and-gradient-copoly-2-oxazoline-micelles-strikingly-different-on-the-inside
#13
Sergey K Filippov, Bart Verbraeken, Petr V Konarev, Dmitri I Svergun, Borislav Angelov, Natalya S Vishnevetskaya, Christine M Papadakis, Sarah Rogers, Aurel Radulescu, Tim Courtin, José C Martins, Larisa Starovoytova, Martin Hruby, Petr Stepanek, Vitaly S Kravchenko, Igor I Potemkin, Richard Hoogenboom
Herein, we provide a direct proof for differences in the micellar structure of amphiphilic diblock and gradient copolymers, thereby unambiguously demonstrating the influence of monomer distribution along the polymer chains on the micellization behavior. The internal structure of amphiphilic block and gradient co poly(2-oxazolines) based on the hydrophilic poly(2-methyl-2-oxazoline) (PMeOx) and the hydrophobic poly(2-phenyl-2-oxazoline) (PPhOx) was studied in water and water-ethanol mixtures by small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), static and dynamic light scattering (SLS/DLS), and (1)H NMR spectroscopy...
August 2, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28754064/development-and-characterization-dual-responsive-magnetic-nanocomposites-for-targeted-drug-delivery-systems
#14
Lida Ahmadkhani, Abolfazl Akbarzadeh, Mojtaba Abbasian
A drug delivery system based on dual responsive units was developed. An appealing pH- and thermo-responsive triblock terpolymer as the drug carrier was synthesized by RAFT polymerization of N-isopropyl acrylamide and methacrylic acid monomers using PEG-RAFT agent. The Fe3O4 magnetic nanoparticles were synthesized by co-precipitation of Fe salts. Synthesized samples were characterized by FT-IR, XRD, GPC, SEM and TEM. The dual responsive behaviour and self-assembly of the triblock terpolymers in aqueous solution were investigated using UV-vis transmittance and DLS...
July 28, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28750162/drug-specificity-synergy-and-antagonism-in-ultrahigh-capacity-poly-2-oxazoline-poly-2-oxazine-based-formulations
#15
Michael M Lübtow, Lukas Hahn, Malik Salman Haider, Robert Luxenhofer
Polymer micelles offer the possibility to create a nanoscopic environment that is distinct from the bulk phase. They find applications in catalysis, drug delivery, cleaning, etc. Often, one simply distinguishes between hydrophilic and hydrophobic, but fine-tuning of the microenvironment is possible by adjusting the structure of the polymer amphiphile. Here, we investigated a small library of structurally similar amphiphiles based on poly(2-oxazoline)s and poly(2-oxazine)s with respect to their solubilization capacity for two extremely water insoluble drugs, curcumin and paclitaxel...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28742224/synthesis-of-unimolecular-micelles-with-incorporated-hyperbranched-boltorn-h30-polyester-modified-with-hyperbranched-helical-poly-phenyl-isocyanide-chains-and-their-enantioselective-crystallization-performance
#16
Zhi-Huang Zhang, Chen-Yang Qiao, Jian Zhang, Wen-Ming Zhang, Jun Yin, Zong-Quan Wu
Here, the fabrication of unimolecular micelles functionalized with helical polymeric chains as a chiral nucleating agent in enantioselective crystallization is reported. Starting from a fractionated hyperbranched polyester (Boltorn H30), the ring-opening polymerization of l-lactic acid (LLA) and subsequent terminal-group modification affords the alkyne-Pd(II)-anchored hyperbranched macroinitiator (H30-PLLA-Pd). By taking advantage of a Pd(II)-catalyzed living polymerization of chiral pendant modified l- or d-phenyl isocyanide (PI) monomers, well-defined chiral unimolecular micelles (H30-PLLA-PPI) grafted with radiating helical PPI coronas of one predominant screw sense are obtained...
July 25, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28737832/self-assembled-polyprodrug-amphiphile-for-subcutaneous-xenograft-tumor-inhibition-with-prolonged-acting-time-in-vivo
#17
Dong Chen, Yu Huang, Shuting Xu, Huangyong Jiang, Jieli Wu, Xin Jin, Xinyuan Zhu
Polymeric drug delivery system termed as "polyprodrug amphiphile" poly(2-methylacryloyloxyethyl phosphorylcholine)-b-poly(10-hydroxy-camptothecin methacrylate (pMPC-b-pHCPT) is developed for the prolonged-acting cancer therapy. It is obtained by two-step reversible addition-fragmentation chain transfer polymerization of zwitterionic monomer MPC and an esterase-responsive polymerizable prodrug methacrylic anhydride-CPT, respectively. This diblock polymer is composed of both antifouling (pMPC) and bioactive (pHCPT) segments and the drug is designed as a building block to construct the polymer skeleton directly...
July 24, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28737259/homopolymer-nanolithography
#18
Moritz Tebbe, Elizabeth Galati, Gilbert C Walker, Eugenia Kumacheva
Future progress in nanoscience and nanotechnology necessitates further development of versatile, labor-, and cost-efficient surface patterning strategies. A new approach to nanopatterning is reported, which utilizes surface segregation of a smooth layer of an end-grafted homopolymer in a poor solvent. The variation in polymer grafting density yields a range of surface nanostructures, including randomly organized pinned spherical micelles, worm-like structures, networks, and porous films. The capability to use the polymer patterns for site-specific deposition of small molecules, polymers, or nanoparticles is shown...
July 24, 2017: Small
https://www.readbyqxmd.com/read/28735537/versatile-tetrablock-copolymer-scaffold-for-hierarchical-colloidal-nanoparticle-assemblies-synthesis-characterization-and-molecular-dynamics-simulation
#19
Gema Marcelo, Fraser Burns, Tânia Ribeiro, J M G Martinho, M Pilar Tarazona, Enrique Saiz, Matthew G Moffitt, José Paulo S Farinha
A unique combination of molecular dynamics (MD) simulation and detailed size exclusion chromatography-multiangle light scattering (SEC-MALS) analysis is used to provide important a priori insights into the solution self-assembly of a well-defined and symmetric tetrablock copolymer with two acrylic acid (AA) outer blocks, two polystyrene (PS) inner blocks, and a trithiocarbonate (TTC) central group, prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. SEC-MALS experiments show that the copolymer forms aggregates in both tetrahydrofuran and N,N-dimethylformamide (DMF), even in the presence of different salts, but not in 1,4-dioxane (dioxane)...
August 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28713159/co-delivery-of-docetaxel-and-silibinin-using-ph-sensitive-micelles-improves-therapy-of-metastatic-breast-cancer
#20
Xin-Yue Dong, Tian-Qun Lang, Qi Yin, Peng-Cheng Zhang, Ya-Ping Li
Breast cancer is the most vicious killer for women, and tumor metastasis is one of the leading causes of breast cancer therapy failure. In this study, a new pH-sensitive polymer (polyethylene glycol-block-poly[(1,4-butanediol)-diacrylate-β-N,N-diisopropylethylenediamine], BDP) was synthesized. Based on BDP, docetaxel/silibinin co-delivery micelles (DSMs) was constructed. DSM had a well-defined spherical shape under the transmission electron microscope with average hydrodynamic diameter of 85.3±0.4 nm, and were stable in the bloodstream but could dissociate to release the chemotherapeutic agents in the low pH environment of the endo/lysosomes in the tumor cells...
July 17, 2017: Acta Pharmacologica Sinica
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