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https://www.readbyqxmd.com/read/28230046/gel-phase-formation-in-dilute-triblock-copolyelectrolyte-complexes
#1
Samanvaya Srivastava, Marat Andreev, Adam E Levi, David J Goldfeld, Jun Mao, William T Heller, Vivek M Prabhu, Juan J de Pablo, Matthew V Tirrell
Assembly of oppositely charged triblock copolyelectrolytes into phase-separated gels at low polymer concentrations (<1% by mass) has been observed in scattering experiments and molecular dynamics simulations. Here we show that in contrast to uncharged, amphiphilic block copolymers that form discrete micelles at low concentrations and enter a phase of strongly interacting micelles in a gradual manner with increasing concentration, the formation of a dilute phase of individual micelles is prevented in polyelectrolyte complexation-driven assembly of triblock copolyelectrolytes...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28223798/transferrin-receptor-targeted-ph-sensitive-micellar-system-for-diminution-of-drug-resistance-and-targetable-delivery-in-multidrug-resistant-breast-cancer
#2
Wei Gao, Guihua Ye, Xiaochuan Duan, Xiaoying Yang, Victor C Yang
The emergence of drug resistance is partially associated with overproduction of transferrin receptor (TfR). To overcome multidrug resistance (MDR) and achieve tumor target delivery, we designed a novel biodegradable pH-sensitive micellar system modified with HAIYPRH, a TfR ligand (7pep). First, the polymers poly(l-histidine)-coupled polyethylene glycol-2000 (PHIS-PEG2000) and 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (7pep-DSPE-PEG2000) were synthesized, and the mixed micelles were prepared by blending of PHIS-PEG2000 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (DSPE-PEG2000) or 7pep-DSPE-PEG2000 (7-pep HD micelles)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28221801/balancing-segregation-and-complexation-in-amphiphilic-copolymers-by-architecture-and-confinement
#3
Pascal Hebbeker, Alexander A Steinschulte, Stefanie Schneider, Felix A Plamper
Segregation is a well-known principle for micellization, as solvophobic components try to minimize interactions with other entities (such as solvent) by self-assembly. An opposite principle is based on complexation (or coacervation), leading to the coassembly/association of different components. Most cases in the literature rely on only one of these modes, though the classical micellization scheme (such as spherical micelles, wormlike micelles, and vesicles) can be enriched by a subtle balance of segregation and complexation...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28221800/self-associating-poly-ethylene-oxide-block-poly-%C3%AE%C2%B5-caprolactone-peo-b-pcl-drug-conjugates-for-the-delivery-of-stat3-inhibitor-jsi-124-potential-application-in-cancer-immunotherapy
#4
Shyam M Garg, Mohammad Reza Vakili, Ommoleila Molavi, Afsaneh Lavasanifar
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) in tumor cells and tumor associated dendritic cells (DCs) plays a major role in the progression of cancer. JSI-124 (Cucurbitacin I) is a potent inhibitor of STAT3, however, its poor solubility and non-specificity limits its effectiveness in cancer immunotherapy. In order to achieve a nano-carrier for solubilisation and passive targeting of JSI-124 to tumor cells and tumor associated DCs, the drug was chemically conjugated to pendent COOH groups of self-associating poly(ethylene oxide)-block-poly(-carboxylate-ε-caprolactone) (PEO-b-PCCL)...
February 21, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28221732/facile-fabrication-of-aie-active-fluorescent-polymeric-nanoparticles-with-ultra-low-critical-micelle-concentration-based-on-ce-iv-redox-polymerization-for-biological-imaging-applications
#5
Qing Wan, Dazhuang Xu, Liucheng Mao, Ziyang He, Guangjian Zeng, Yingge Shi, Fengjie Deng, Meiying Liu, Xiaoyong Zhang, Yen Wei
Fluorescent polymeric nanoparticles (FPNs) with aggregation-induced emission (AIE) property have received increasing attention and possess promising biomedical application potential in the recent years. Many efforts have been devoted to the fabrication methodologies of FPNs and significant advance has been achieved. In this contribution, a novel strategy for the fabrication of AIE-active amphiphilic copolymers is reported for the first time based on the Ce(IV) redox polymerization. As an example, ene group containing AIE-active dye (named as Phe-alc) is directly grafted onto a water soluble polymer polyethylene glycol (PEG) in H2 O/THF system under low temperature...
February 21, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28221045/hierarchical-colloidal-polymeric-structure-from-surfactant-like-amphiphiles-in-selective-solvents
#6
Chenglin Wang, Shiying Ma, Yi Hu, Rong Wang
We investigated the self-assembly of surfactant-like amphiphile consisting of a hydrophilic head and a hydrophobic tail using dissipative particle dynamics method. By controlling the interaction parameter between the hydrophilic head and the solvent, the length of hydrophobic tail, the size of hydrophilic head, and the polymer concentration, we found seven self-assembled morphologies, including sphere-like micelle, pomegranate-like micelle, hierarchical colloidal polymeric structure, pomegranate-like columnar structure, branched hybrid structure, disk-like micelle, and vesicle...
February 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28219244/an-alternative-route-to-nanoscale-aggregates-with-a-ph-responsive-random-copolymer
#7
Jonathan C Pegg, Adam Czajka, Christopher Hill, Craig James, Jocelyn Alice Peach, Sarah E Rogers, Julian Eastoe
A random copolymer, poly(methyl methacrylate-co-2-dimethylaminoethyl methacrylate) (poly(MMA-co-DMAEMA)) is shown to form nano-scale aggregates (NAs) (~20 nm) at copolymer concentrations ≥ 10 % w/w, directly from the pre-formed surfactant-stabilised latex (~120 nm) in aqueous solution. The copolymer is prepared by a conventional emulsion polymerisation. Introducing a small mole fraction of DMAEMA (~10 %) allows the copolymer hydrophilicity to be adjusted by pH and external temperature, generating NAs with tuneable sizes and defined weight-average aggregation number, as observed by dynamic-light scattering (DLS) and small-angle neutron scattering (SANS)...
February 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28215509/triphenylphosphonium-modified-poly-ethylene-glycol-poly-%C3%AE%C2%B5-caprolactone-micelles-for-mitochondria-targeted-gambogic-acid-delivery
#8
Yingqi Xu, Shengpeng Wang, Hon Fai Chan, Yuling Liu, Hui Li, Chengwei He, Zeyong Li, Meiwan Chen
Mitochondria are important targets for the intracellular delivery of drugs and DNA. For mitochondria-targeted delivery, a mitochondriotropic molecule, triphenylphosphonium (TPP), was applied to the synthesis of amphiphilic TPP-poly(ethylene glycol)-poly(ε-caprolactone) (TPP-PEG-PCL) polymers. The TPP-PEG-PCL polymer was used to prepare micelles using a solvent evaporation method for the delivery of gambogic acid (GA) (GA-TPP). The micelles were obtained with a favorable particle size of 150.07±11.71nm and an encapsulation efficiency of 80...
February 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28215155/magnetic-nanoparticles-new-perspectives-in-drug-delivery
#9
Joanna Wong, Jeremy Prout, Alexander Seifalian
BACKGROUND: The study of magnetic nanoparticles (MNPs) for drug delivery has recently seen a surge of interest even though the first studies were conducted as early as in the seventies. Despite this, there are still gaps in the knowledge of the field, implicating the complexities in designing the ideal MNP for drug delivery. The large surface area of MNPs and the ability to manipulate with an externally applied magnetic field render the MNP a good candidate for targeted delivery of drugs...
February 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28211226/supramolecularly-engineered-amphiphilic-macromolecules-molecular-interaction-overrules-packing-parameters
#10
Prithankar Pramanik, Debes Ray, Vinod K Aswal, Suhrit Ghosh
We report molecular interaction-driven self-assembly of supramolecularly engineered amphiphilic macromolecules (SEAM) containing a single supramolecular structure-directing unit (SSDU) consisting of an H-bonding group connected to a naphthalene diimide chromophore. Two such SEAMs, P1-50 and P2-50, having the identical chemical structure and hydrophobic/hydrophilic balance, exhibit distinct self-assembled structures (polymersome and cylindrical micelle, respectively) due to a difference in the H-bonding group (hydrazide or amide, respectively) of the single SSDU...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28193561/hydrophobic-carbon-dot-based-dual-emission-micelle-for-ratiometric-fluorescence-biosensing-and-imaging-of-cu-2-in-liver-cells
#11
Linlin Lu, Chongchong Feng, Jie Xu, Fengyang Wang, Haijun Yu, Zhiai Xu, Wen Zhang
Copper is closely related to liver damage, therefore, it is essential to develop a simple and sensitive strategy to detect copper ions (Cu(2+)) in liver cells. A hydrophobic carbon dots (HCDs)-based dual-emission fluorescent probe for Cu(2+) was prepared by encapsulating HCDs in micelles formed by self-assembly of amphiphilic polymer DSPE-PEG and tetrakis (4-carboxyphenyl) porphyrin (TCPP)-modified DSPE-PEG. The obtained probe showed characteristic fluorescence emissions of HCDs and TCPP with large emission shift of 170nm with single-wavelength excitation...
January 31, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28186408/functional-microgels-and-microgel-systems
#12
Felix A Plamper, Walter Richtering
Microgels are macromolecular networks swollen by the solvent in which they are dissolved. They are unique systems that are distinctly different from common colloids, such as, e.g., rigid nanoparticles, flexible macromolecules, micelles, or vesicles. The size of the microgel networks is in the range of several micrometers down to nanometers (then sometimes called "nanogels"). In a collapsed state, they might resemble hard colloids but they can still contain significant amounts of solvent. When swollen, they are soft and have a fuzzy surface with dangling chains...
February 10, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28181619/phosphatase-triggered-cell-selective-release-of-a-pt-iv-backboned-prodrug-like-polymer-for-an-improved-therapeutic-index
#13
Shao-Lu Li, Yingqin Hou, Yali Hu, Jin Yu, Wei Wei, Hua Lu
We describe here the synthesis and cell-selective delivery of a cationic Pt(iv)-backboned prodrug-like polymer P(DSP-DAEP). P(DSP-DAEP) features excellent aqueous solubility, unusually high (44.5%) drug loading, can be rapidly reduced to release the active cisplatin, and is more potent than its small molecular Pt(iv) precursor DSP. P(DSP-DAEP) can be formulated with an oppositely charged methoxyl poly(ethylene glycol)-block-poly(l-phosphotyrosine) (mPEG-b-PpY) to afford a polyion micelle (Pt-PIC) by taking advantage of polyelectrolyte coacervation...
February 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28176270/polymers-in-the-co-delivery-of-sirna-and-anticancer-drugs-for-the-treatment-of-drug-resistant-cancers
#14
REVIEW
Haotian Sun, Iven Yarovoy, Meghan Capeling, Chong Cheng
Recently, co-delivery of siRNA and anticancer drugs has drawn much attention in the treatment of drug-resistant cancers. Drug resistance is exhibited by cancer cells, which limits the efficacy of chemotherapy. When siRNA and anticancer drugs are delivered into cancer cells simultaneously, the siRNA is expected to silence the genes related to drug resistance, decreasing the drug efflux pumps and activating the cell's apoptosis pathways. In a timeframe following the release of siRNA, the accumulation of the co-delivered anti-cancer drug inside of the cancer cells will increase, resulting in promoted chemotherapeutic effects...
April 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28166373/aqueous-self-assembly-of-y-shaped-amphiphilic-block-copolymers-into-giant-vesicles
#15
Hanping Li, Yong Jin, Baozhu Fan, Shuangquan Lai, Xiaopeng Sun, Rui Qi
The preparation and aqueous self-assembly of newly Y-shaped amphiphilic block polyurethane (PUG) copolymers are reported here. These amphiphilic copolymers, designed to have two hydrophilic poly(ethylene oxide) (PEO) tails and one hydrophobic alkyl tail via a two-step coupling reaction, can self-assemble into giant unilamellar vesicles (GUVs) (diameter ≥ 1000 nm) with a direct dissolution method in aqueous solution, depending on their Y-shaped structures and initial concentrations. More interesting, the copolymers can self-assemble into various distinct nano-/microstructures, such as spherical micelles, small vesicles, and GUVs, with the increase of their concentrations...
February 6, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28165815/effective-improvement-of-the-neuroprotective-activity-after-spinal-cord-injury-by-synergistic-effect-of-glucocorticoid-with-biodegradable-amphipathic-nanomicelles
#16
YueLong Wang, Min Wu, Lei Gu, XiaoLing Li, Jun He, LiangXue Zhou, Aiping Tong, Juan Shi, HongYan Zhu, JianGuo Xu, Gang Guo
Dexamethasone acetate (DA) produces neuroprotective effects by inhibiting lipid peroxidation and inflammation by reducing cytokine release and expression. However, its clinical application is limited by its hydrophobicity, low biocompatibility and numerous side effects when using large dosage. Therefore, improving DA's water solubility, biocompatibility and reducing its side effects are important goals that will improve its clinical utility. The objective of this study is to use a biodegradable polymer as the delivery vehicle for DA to achieve the synergism between inhibiting lipid peroxidation and inflammation effects of the hydrophobic-loaded drugs and the amphipathic delivery vehicle...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165737/phosphonium-functionalized-polymer-micelles-with-intrinsic-antibacterial-activity
#17
Benjamin Hisey, Paul J Ragogna, Elizabeth R Gillies
New approaches to treat bacterial infections are badly needed to address the increasing problem of antibiotic-resistance. This study explores phosphonium-functionalized block copolymer micelles as intrinsically antibacterial polymer assemblies. Phosphonium cations with varying alkyl lengths were conjugated to the terminus of a poly(ethylene oxide)-polycaprolactone block copolymer and the phosphonium-functionalized block copolymers were self-assembled to form micelles in aqueous solution. The size, morphology, and ζ-potential of the assemblies were studied and their abilities to kill Escherichia coli and Staphylococcus aureus were evaluated...
February 6, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28163163/mixed-micelles-of-lipoic-acid-chitosan-poly-ethylene-glycol-and-distearoylphosphatidylethanolamine-poly-ethylene-glycol-for-tumor-delivery
#18
Zeeneh Elsaid, Kevin M G Taylor, Sanyogitta Puri, Cath A Eberlein, Khuloud Al-Jamal, Jie Bai, Rebecca Klippstein, Julie Tzu-Wen Wang, Ben Forbes, Jasminder Chana, Satyanarayana Somavarapu
Many chemotherapeutics suffer from poor aqueous solubility and tissue selectivity. Distearoylphosphatidylethanolamine-poly(ethylene glycol) (DSPE-PEG) micelles are a promising formulation strategy for the delivery of hydrophobic anticancer drugs. However, storage and in vivo instability restrict their use. The aim of this study was to prepare mixed micelles, containing a novel polymer, lipoic acid-chitosan-poly(ethylene glycol) (LACPEG), and DSPE-PEG, to overcome these limitations and potentially increase cancer cell internalisation...
February 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28157632/in-situ-investigation-of-aggregate-sizes-formed-using-thermo-responsive-polymers-effect-of-temperature-and-shear
#19
Wei Sung Ng, Luke A Connal, Elizaveta Forbes, Krishna Mohanarangam, George V Franks
Temperature-responsive flocculants, such as poly(N-isopropylacrylamide) (PNIPAM), induce reversible particle aggregation upon heating above a lower critical solution temperature (LCST). The aim of this work is to investigate the aggregation of ground iron ore using PNIPAM and conventional polyacrylamide (PAM) flocculants in a continuously-sheared suspension, through in situ chord length measurements using Focused Beam Reflectance Measurement techniques and real-time imaging of the particle aggregates. In the presence of uncharged PNIPAM, particle aggregation occurs only upon heating to the LCST, and the aggregates continue to grow with further heating...
May 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28156164/cholesterol-conjugated-poly-d-l-lactide-based-micelles-as-a-nanocarrier-system-for-effective-delivery-of-curcumin-in-cancer-therapy
#20
Preeti Kumari, Omkara Swami Muddineti, Sri Vishnu Kiran Rompicharla, Pratyusha Ghanta, Adithya Karthik B B N, Balaram Ghosh, Swati Biswas
Polymeric micelles have been widely explored preclinically as suitable delivery systems for poorly soluble chemotherapeutic drugs in cancer therapy. The present study reported the development of cholesterol (Ch)-conjugated poly(D,L-Lactide) (PLA)-based polymeric micelles (mPEG-PLA-Ch) for effective encapsulation and delivery of curcumin (CUR) at the tumor site. Cholesterol conjugation dramatically affected the particle size and improved drug loading (DL) and encapsulation efficiency (EE). mPEG-PLA-Ch-CUR showed bigger hydrodynamic diameter (104...
November 2017: Drug Delivery
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