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https://www.readbyqxmd.com/read/29916192/imidazole-bearing-polymeric-micelles-for-enhanced-cellular-uptake-rapid-endosomal-escape-and-on-demand-cargo-release
#1
Di Lu, Yang An, Simin Feng, Xiaodan Li, Aiping Fan, Zheng Wang, Yanjun Zhao
The complex design of multifunctional nanomedicine is beneficial to overcome the multiple biological barriers of drug delivery, but it also presents additional hurdles to clinical translation (e.g., scaling-up and quality control). To address this dilemma, we employed a simple imidazole-bearing polymer micelle for enhanced cellular uptake, facilitated endosomal escape, and on-demand release of a model drug, SN-38. The micelles were crosslinked by the reversible imidazole/Zn2+ coordination with a drug loading of ca...
June 18, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29915431/a-vinyl-ether-functional-polycarbonate-as-a-template-for-multiple-postpolymerization-modifications
#2
Sangho Cho, Gyu Seong Heo, Sarosh Khan, Jessica Huang, David A Hunstad, Mahmoud Elsabahy, Karen L Wooley
A highly-reactive vinyl ether-functionalized aliphatic polycarbonate and its block copolymer were developed as templates for multiple post-polymerization conjugation chemistries. The vinyl ether-functional six-membered cyclic carbonate monomer was synthesized by a well-established two-step procedure starting from 2,2-bis(hydroxymethyl)propionic acid. An organobase-catalyzed ring-opening polymerization of the synthesized monomer afforded polycarbonates with pendant vinyl ether functionalities (PMVEC). The vinyl ether moieties on the resulting polymers were readily conjugated with hydroxyl- or thiol-containing compounds via three different post-polymerization modification chemistries - acetalization, thio-acetalization, and thiol-ene reaction...
May 8, 2018: Macromolecules
https://www.readbyqxmd.com/read/29911854/chiral-poly-ionic-liquid-with-non-conjugated-backbone-as-fluorescent-enantioselective-sensor-for-phenylalaninol-and-tryptophan
#3
Datong Wu, Yin Yu, Jie Zhang, Lili Guo, Yong Kong
Here a novel fluorescent chiral poly(ionic liquid) (S)-PCIL-4 with non-conjugated backbone is designed and synthesized in the control of micelle through free radical polymerization, whose fluorescence emission maximum is at λem,max = 430 nm. It is observed that polymers with spatially proximate units (phenyl group and pyridinium cation) have photoluminescence through spatial π-π and ion-π interaction. Then (S)-PCIL-4 can be served as a fluorescent turn-off/on sensor for chiral recognition of phenylalaninol and tryptophan in the presence of Cu(II)...
June 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29906397/synthesis-of-single-walled-carbon-nanotubes-coated-with-thiol-reactive-gel-via-emulsion-polymerization
#4
Yukiko Nagai, Yusuke Tsutsumi, Naotoshi Nakashima, Tsuyohiko Fujigaya
Single-walled carbon nanotubes (SWNTs) have unique near-infrared absorption and photoemission properties that are attractive for in vivo biological applications such as photothermal cancer treatment and bioimaging. Therefore, a smart functionalization strategy for SWNTs to create biocompatible surfaces and introduce various ligands to target active cancer cells without losing the unique optical properties of the SWNTs is strongly desired. This paper reports the de-sign and synthesis of a SWNT/gel hybrid containing maleimide groups, which react with various thiol compounds through Michael addition reactions...
June 15, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29901244/polymer-meets-frustrated-lewis-pair-second-generation-co2-responsive-nanosystem-for-sustainable-co2-conversion
#5
Qiang Yan, Liang Chen, Renjie Liu
Frustrated Lewis pair (FLP), as a couple of sterically encumbered Lewis acid and Lewis base, can offer latent reactivity for activating inert gas molecules. However, their use as a platform for fabricating gas-responsive materials has yet developed. Merging FLP concept and polymers, we report a new generation of CO2-responsive system, differing from the first-generation ones based on acid-base equilibrium mechanism. Two complementary Lewis acidic and basic block copolymers, installing bulky borane- and phosphine-containing blocks, were built as the macromolecular FLP...
June 14, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29889515/targeting-protumoral-tumor-associated-macrophages-with-nanobody-functionalized-nanogels-through-spaac-ligation
#6
Lutz Nuhn, Evangelin Boli, Sam Massa, Isabel Vandenberghe, Kiavash Movahedi, Bart Devreese, Jo Van Ginderachter, Bruno G De Geest
Tumor-associated macrophages (TAMs) with high expression levels of the Macrophage Mannose Receptor (MMR, CD206) exhibit a strong angiogenic and immune suppressive activity. Thus, they are a highly attractive target in cancer immunotherapy, with the aim to modulate their protumoral behavior. Here, we introduce polymer nanogels as potential drug nanocarriers which were site-specifically decorated with a Nanobody (Nb) specific for the MMR. Using azide-functionalized RAFT chain transfer agents they provide access to amphiphilic reactive ester block copolymers that self-assemble into micelles and are afterwards core-crosslinked towards fully hydrophilic nanogels with terminal azide groups on their surface...
June 11, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29889346/enzyme-compatible-dynamic-nanoreactors-from-electrostatically-bridged-like-charged-surfactants-and-polyelectrolytes
#7
Larisa A Tsarkova, Martin J Thiele, Mehdi D Davari, Isabell Hofmann, Melanie König, Carlos G Lopez, Ljubica Vojcic, Walter Richtering, Ulrich Schwaneberg
We report an unanticipated mechanism of electrostatic attractive interactions of fully neutralized polyacrylic acid (PAA) with like-charged surfactants. Amphiphilic polymer-surfactant complexes with high interfacial activity and solubilisation capacity exceeding that of conventional micelles are formed via bridging with Ca2+ ions. Incorporation of a protease into such dynamic nanoreactors results in a synergistically enhanced cleaning performance due to the improved solubilization of poorly water-soluble immobilized proteins...
June 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29885851/n-2-hydroxypropyl-methacrylamide-polymer-conjugated-pyropheophorbide-a-a-promising-tumor-targeted-theranostic-probe-for-photodynamic-therapy-and-imaging
#8
Jun Fang, Vladimír Šubr, Waliul Md Islam, Steffen Hackbarth, Rayhanul Md Islam, Tomáš Etrych, Karel Ulbrich, Hiroshi Maeda
Tumor-targeted photodynamic therapy (PDT) using polymeric photosensitizers is a promising therapeutic strategy for cancer treatment. In this study, we synthesized a pHPMA conjugated pyropheophorbide-a (P-PyF) as a cancer theranostic agent for PDT and photodynamic diagnostics (PDD). Pyropheophorbide-a has one carboxyl group which was conjugated to pHPMA via amide bond yielding the intended product with high purity. In aqueous solutions, P-PyF showed a mean particle size of ∼200 nm as it forms micelle which exhibited fluorescence quenching and thus very little singlet oxygen (1 O2 ) production...
June 7, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29885530/a-multi-functional-polymeric-carrier-for-simultaneous-positron-emission-tomography-imaging-and-combination-therapy
#9
Jingjing Sun, Lingyi Sun, Jianchun Li, Jieni Xu, Zhuoya Wan, Zubin Ouyang, Lei Liang, Song Li, Dexing Zeng
Multifunctional nanoplatforms offering simultaneous imaging and therapeutic functions have been recognized as a highly promising strategy for personalized nanomedicine. In this work, we synthesized a farnesylthiosalicylate (FTS, a nontoxic Ras antagonist) based triblock copolymer POEG-b-PVBA-b-PFTS (POVF) composed of a poly(oligo(ethylene glycol) methacrylate) (POEG) hydrophilic block, a poly(FTS) hydrophobic block, and a poly(4-vinylbenzyl azide) (PVBA) middle block. The POVF polymer itself was active in inhibiting the tumor growth in vitro and in vivo...
June 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29883544/the-importance-of-encapsulation-stability-of-nanocarriers-with-high-drug-loading-capacity-for-increasing-in-vivo-therapeutic-efficacy
#10
L Palanikumar, Eun Seong Choi, Jun Yong Oh, Soo Ah Park, Huyeon Choi, Kibeom Kim, Chaekyu Kim, Ja-Hyoung Ryu
Current drug delivery systems are hampered by poor delivery to tumors, in part reflecting poor encapsulation stability of nanocarriers. Although nanocarriers such as polymeric micelles have high colloidal stability and do not aggregate or precipitate in bulk solution, nanocarriers with low encapsulation stability can lose their cargo during circulation in blood, due to interactions with blood cells, cellular membranes, serum proteins, and other biomacromolecules. The resulting premature drug release from carriers limits the therapeutic efficacy at target sites...
June 8, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29882845/polymeric-micelles-based-on-modified-glycol-chitosan-for-paclitaxel-delivery-preparation-characterization-and-evaluation
#11
Na Liang, Shaoping Sun, Xianfeng Gong, Qiang Li, Pengfei Yan, Fude Cui
Amphiphilic polymer of α-tocopherol succinate modified glycol chitosan (TS-GC) was successfully constructed by conjugating α-tocopherol succinate to the skeleton of glycol chitosan and characterized by Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance (¹H-NMR). In aqueous milieu, the conjugates self-assembled to micelles with the critical aggregation concentration of 7.2 × 10−3 mg/mL. Transmission electron microscope (TEM) observation and dynamic light scattering (DLS) measurements were carried out to determine the physicochemical properties of the micelles...
May 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29875669/ph-responsive-polymer-micelles-enhances-inhibitory-efficacy-on-metastasis-of-murine-breast-cancer-cells
#12
Jie Wang, Gejing De, Qiaoxin Yue, Hai Ma, Jintang Cheng, Guangwei Zhu, Maobo Du, Hong Yi, Qinghe Zhao, Yanjun Chen
A pH sensitive micellar cargo was fabricated for pH triggered delivery of hydrophobic drug paclitaxel with pH controlled drug release profiles. The size, drug loading content, and encapsulation efficiency of PTX loaded micelles were 20-30 nm, 7.5%, 82.5%, respectively. PTX loaded PELA-PBAE micelles could enhance the intracellular uptake of a model drug significantly, with increased cytotoxicity and inhibition of tumor metastasis on 4T1 cells, as confirmed by wound healing assay and tumor cells invasion assay...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29875350/biodistribution-and-toxicity-of-micellar-platinum-nanoparticles-in-mice-via-intravenous-administration
#13
Anna L Brown, Marc P Kai, Allison N DuRoss, Gaurav Sahay, Conroy Sun
Platinum nanoparticles (PtNPs) have shown promise as diagnostic and therapeutic agents due to their unique physiochemical properties. However, critical parameters, such as toxicity and accumulation at both desired and other tissues, remain a significant concern in the clinical translation of these nanomaterials. Here, we examine the cytotoxicity, biodistribution, and effect on clearance organ function of an intravenously administered polyethylene glycol (PEG) -ylated PtNP construct. We synthesized hydrophobic PtNPs and assembled them into aqueous micelles with the lipid-polymer conjugate 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-PEG (PtNP: DSPE-PEG, ~70 nm)...
June 7, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29870261/synthesis-and-self-assembly-of-the-ph-responsive-anionic-copolymers-for-enhanced-doxorubicin-loading-capacity
#14
Meijun Yi, Qian Lu, Yuping Zhao, Chenqian Cheng, Shiping Zhang
Polyelectrolyte complex micelle self-assembled from an ionic polymer and oppositely charged small molecules is a promising drug delivery system. In this study, the anionic block copolymers composed of poly(ethylene glycol), poly(ε-caprolactone) and carboxyl modified poly(ε-caprolactone), COOH-PCEC were designed to encapsulate doxorubicin (DOX) via electrostatic and hydrophobic interactions to form spherical micelles with a particle size of 90-140 nm. The higher payload capacity of these micelles than non-charged micelles of PCL-PEG-PCL (PCEC) was achieved and it was strongly dependent on the composition of the micelles...
June 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29870241/biocompatible-unimolecular-micelles-obtained-via-the-passerini-reaction-as-versatile-nanocarriers-for-potential-medical-applications
#15
Stefan Oelmann, Alessandra Travanut, Dennis Barther, Manuel Romero, Steven M Howdle, Cameron Alexander, Michael A R Meier
A Passerini three component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5-10 repeating units and the side chain ends were conjugated by performing a Passerini-3CR with PEG-isocyanide and/or PEG-aldehyde (950 g/mol). The resulting amphiphilic star-shaped block copolymers contained thioether groups, which could be oxidized to sulfones in order to tune the polarity of the polymer chains...
June 5, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29869424/recent-progress-in-macromolecule-anchored-hybrid-gold-nanomaterials-for-biomedical-applications
#16
REVIEW
Zheng Luo, Yang Xu, Enyi Ye, Zibiao Li, Yun-Long Wu
Gold nanoparticles (AuNPs), with elegant thermal, optical, or chemical properties due to quantum size effects, may serve as unique species for therapeutic or diagnostic applications. It is worth mentioning that their small size also results in high surface activity, leading to significantly impaired stability, which greatly hinders their biomedical utilizations. To overcome this problem, various types of macromolecular materials are utilized to anchor AuNPs so as to achieve advanced synergistic effect by dispersing, protecting, and stabilizing the AuNPs in polymeric-Au hybrid self-assemblies...
June 4, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29864287/small-delivery-vehicles-of-sirna-for-enhanced-cancer-targeting
#17
Hyun Jin Kim, Yu Yi, Ahram Kim, Kanjiro Miyata
Small interfering RNA (siRNA) drugs have been considered to treat various diseases in major organs. However, siRNA drugs developed for cancer therapy are hindered from proceeding to clinics. To date, various delivery formulations have been developed from cationic lipids, polymers, and/or inorganic nanoparticles for systemic siRNA delivery to solid tumors. Most of these delivery vehicles do not generate small particle sizes and pharmacokinetics required for accumulation in target cancer cells, compared with clinically tested anticancer drug-loaded polymeric micelles...
June 4, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29851539/synthesis-characterization-and-in-vitro-evaluation-of-trail-modified-cabazitaxel-loaded-polymeric-micelles-for-achieving-synergistic-anticancer-therapy
#18
Caochuan Feng, Xiaoxiong Han, Lili Chi, Jing Sun, Feirong Gong, Yaling Shen
Combination therapy of two or more drugs has gradually become of outmost importance in cancer treatment. Cabazitaxel (CTX) is a taxoid drug and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of TNF superfamily. In this study, we prepared TRAIL-modified and CTX-loaded polymer micelle (TRAIL-M-CTX). This nanoparticle was self-assembled from biodegradable amphiphilic copolymers, monomethoxyl poly(ethylene glycol)-b-poly(DL-lactide) (mPEG-PLA) and COOH-PEG-PLA, via a nanoprecipitation method and were modified with the TRAIL protein, resulting in a particle size of 39...
May 31, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29847730/the-blood-clearance-kinetics-and-pathway-of-polymeric-micelles-in-cancer-drug-delivery
#19
Xuanrong Sun, Guowei Wang, Hao Zhang, Shiqi Hu, Xin Liu, Jianbin Tang, Youqing Shen
Polymer micelles are one of the most investigated nanocarriers for drug delivery; many have entered clinical trials and some are in clinic use, but their delivery systems have not yet shown the expected high therapeutic efficacy in clinics. Further understanding their in vivo behaviors, particularly how quickly and by what mechanism polymer micelles are cleared (i.e., via micelles or unimers) once injected, is key to solving this dilemma. Herein, we hope to answer these questions for the clinically relevant polyethylene glycol-block-poly(ɛ-caprolactone) (PEG-PCL) and PEG-block-poly(DL-lactide) (PEG-PDLLA) micelles...
May 30, 2018: ACS Nano
https://www.readbyqxmd.com/read/29847210/hyaluronic-acid-modified-mpeg-b-pae-block-copolymer-aqueous-micelles-for-efficient-ophthalmic-drug-delivery-of-hydrophobic-genistein
#20
Cong Li, Rui Chen, Mengzhen Xu, Jiyan Qiao, Liang Yan, Xin Dong Guo
The ophthalmic drug delivery is a challenge in the clinical treatment of ocular diseases. The traditional drug administration usually shows apparent limitations, such as the low bioavailability from the reason of low penetration of the cornea and the short survival time of drug in the eyes. To overcome these shortcomings, we propose an amphiphilic polymer micelle modified with hyaluronic acid (HA) for high efficient ophthalmic delivery of genistein, a widely used hydrophobic drug for treatment of ocular angiogenesis...
November 2018: Drug Delivery
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