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https://www.readbyqxmd.com/read/29766467/thrombotic-microangiopathy-on-kidney-biopsy-in-a-patient-with-tafro-syndrome
#1
Toshikazu Ozeki, Masashi Tsuji, Junichiro Yamamoto, Chisato Shigematsu, Shoichi Maruyama
TAFRO syndrome represents a characteristic constellation of symptoms comprising Thrombocytopenia, Anasarca, myeloFibrosis, Renal dysfunction, and Organomegaly, and is considered to be a clinicopathologic variant of idiopathic multicentric Castleman disease. A 51-year-old woman was admitted to the hospital complaining of abdominal distension. Findings on physical examination were indicative of anasarca. Computed tomography revealed mild splenomegaly, pericardial effusion, pleural effusion, ascites, and paraaortic lymphadenopathy...
May 15, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29760160/development-of-a-novel-clinical-staging-model-for-cirrhosis-using-the-nationwide-inpatient-sample
#2
Mona Haj, Mary Hart, Don C Rockey
Scoring systems such as Model for End-stage Liver Disease (MELD) and Child-Pugh are often used by clinicians to determine prognosis in patients with cirrhosis. Since clinical complications are important in determining cirrhosis outcomes, our goal was to use these to develop a novel prognostic staging model. Data from the Nationwide Inpatient Sample (NIS), years 2003-2011, were queried for records of patients over the age of 18 with cirrhosis excluding patients with prior or inpatient liver transplantation. The primary outcome was inpatient mortality with focus on cirrhosis-related complications: non-bleeding esophageal varices, variceal hemorrhage, ascites, hepatic encephalopathy (HE), spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS)...
May 14, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29736200/adipose-derived-mesenchymal-stem-cell-derived-exosomes-alleviate-overwhelming-systemic-inflammatory-reaction-and-organ-damage-and-improve-outcome-in-rat-sepsis-syndrome
#3
Chia-Lo Chang, Pei-Hsun Sung, Kuan-Hung Chen, Pei-Lin Shao, Chih-Chao Yang, Ben-Chung Cheng, Kun-Chen Lin, Chih-Hung Chen, Han-Tan Chai, Hsueh-Wen Chang, Hon-Kan Yip, Hong-Hwa Chen
This study tested the hypothesis that healthy adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes (HMSCEXO ) and apoptotic (A) (induced by 12 h hypoxia/12 h starvation)-ADMSC-derived exosomes (AMSCEXO ) were comparably effective at alleviating sepsis syndrome [SS; induced by cecal-ligation and puncture (CLP)]-induced systemic inflammation and reduced organ damage and unfavorable outcomes in rats. SD rats were divided into sham control (SC), SS only, SS + HMSCEXO (100 µg intravenous administration 3 h after CLP), and AMSCEXO ...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29731094/how-to-reconstruct-middle-hepatic-vein-branches-with-explanted-portal-vein-and-inferior-mesenteric-vein-graft-a-case-report
#4
S Junrungsee, W Lapisatepun, A Chotirosniramit, T Sandhu, K Udomsin, W Ko-Iam, P Chanthima, W Lapisatepun, S Boonsri, S Lorsomradee
OBJECTIVE: The middle hepatic vein reconstruction is one of the crucial parts in adult living donor liver transplantation. Numerous techniques had been reported by using cadaveric iliac vessel or synthetic graft. The limitations of reported techniques are availability of the vessel and complication of synthetic graft. We report the technique of using explanted portal vein and inferior mesenteric vein graft in sequential fashion. PATIENTS AND METHODS: The recipient was a 54-year-old man with chronic hepatitis B cirrhosis and multiple hepatocellular carcinomas...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29725793/nonselective-beta-blockers-do-not-affect-survival-in-cirrhotic-patients-with-ascites
#5
REVIEW
Antonio Facciorusso, Sunil Roy, Sarantis Livadas, Adwalia Fevrier-Paul, Clara Wekesa, Ismail Dogu Kilic, Amit Kumar Chaurasia, Mina Sadeq, Nicola Muscatiello
BACKGROUND: The role of nonselective beta-blockers in cirrhotic patients with ascites has been recently questioned; however, definitive evidence in this regard is still lacking. AIMS: To analyze published data on the influence of nonselective beta-blockers as compared to control group on survival of cirrhotic patients with ascites. METHODS: Computerized bibliographic search on the main databases was performed. Hazard ratios from Kaplan-Meier curves were extracted in order to perform an unbiased comparison of survival estimates...
May 3, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29702119/glomeruloid-hemangioma-associated-with-tafro-syndrome
#6
Aya Shinozaki-Ushiku, Takaaki Higashihara, Masako Ikemura, Junichiro Sato, Masaomi Nangaku, Tetsuo Ushiku, Masashi Fukayama
Glomeruloid hemangioma is a rare cutaneous lesion which has been considered as a specific cutaneous marker of POEMS syndrome. Herein, we present the first case of glomeruloid hemangioma associated with TAFRO syndrome, a unique variant of idiopathic multicentric Castleman's disease (iMCD). The patient is a 74-year-old female presented with fever, cervical lymphadenopathy, thrombocytopenia, bilateral pleural effusions and ascites. Biopsy of the lymph node revealed MCD-like histology and bone marrow biopsy showed mild reticulin fibrosis, consistent with TAFRO syndrome...
April 24, 2018: Human Pathology
https://www.readbyqxmd.com/read/29700095/management-of-decompensated-cirrhosis
#7
Dina Mansour, Stuart McPherson
Decompensated cirrhosis is a common reason for admission to the acute medical unit, and such patients typically have complex medical needs and are at high risk of in-hospital death. It is therefore vital that these patients receive appropriate investigations and management as early as possible in their patient journey. Typical presenting clinical features include jaundice, ascites, hepatic encephalopathy, hepato-renal syndrome or variceal haemorrhage. A careful history, examination and investigations can help identify the precipitating cause (infections, gastrointestinal bleeding, high alcohol intake / alcohol-related hepatitis or drug-induced liver injury), so appropriate treatment can be given...
April 1, 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29690960/is-hepatovenocaval-syndrome-a-different-entity-from-budd-chiari-syndrome-in-children
#8
Nadia Waheed, Huma Arshad Cheema, Hassan Suleman, Iqra Mushtaq, Zafar Fayyaz, Nadeem Anjum
OBJECTIVE: To differentiate between clinical and demographic spectrum, and outcome in hepatovenocaval syndrome (HVCS) and Budd-Chiari syndrome (BCS). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Division of Pediatric Gastroenterology, Hepatology and Nutrition, The Children Hospital, Lahore, from January 2014 to January 2017. METHODOLOGY: All children less than 18 years of age, presenting with ascites and visible veins over abdomen, flanks and back were enrolled in the study...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29689120/acute-on-chronic-liver-failure-getting-ready-for-prime-time
#9
Jasmohan S Bajaj, Richard Moreau, Patrick S Kamath, Hugo E Vargas, Vicente Arroyo, K Rajender Reddy, Gyongyi Szabo, Puneeta Tandon, Jody Olson, Constantine Karvellas, Thierry Gustot, Jennifer C Lai, Florence Wong
Acute on chronic liver failure (ACLF) is a culmination of chronic liver disease and extra-hepatic organ failures, which is associated with a high short-term mortality and immense healthcare expenditure. There are varying definitions for organ failures and ACLF in Europe, North America and Asia. These differing definitions need to be reconciled to enhance progress in the field. The pathogenesis of ACLF is multi-factorial and related to interactions between the immuno-inflammatory system, microbiota and the precipitating factors...
April 24, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29678132/neck-circumference-may-be-a-valuable-tool-for-screening-individuals-with-obesity-findings-from-a-young-chinese-population-and-a-meta-analysis
#10
Xiaoting Pei, Li Liu, Mustapha Umar Imam, Ming Lu, Yanzi Chen, Panpan Sun, Yaxin Guo, Yiping Xu, Zhiguang Ping, Xiaoli Fu
BACKGROUND: Central obesity and overweight/obesity can result in various chronic non-communicable diseases, such as cardiovascular disease, metabolic syndrome, and diabetes mellitus. Waist circumference (WC) and body mass index (BMI) are widely used to measure obesity despite their limitations. For example, WC and BMI cannot be measured in pregnant women and subjects with abdominal ascites or masses. Therefore, this study aims to determine the efficacy of neck circumference (NC) as a tool for screening central obesity and overweight/obesity...
April 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29670387/systemic-inflammatory-response-syndrome-and-model-for-end-stage-liver-disease-score-accurately-predict-the-in-hospital-mortality-of-black-african-patients-with-decompensated-cirrhosis-at-initial-hospitalization-a-retrospective-cohort-study
#11
Alassan Kouamé Mahassadi, Justine Laure Konang Nguieguia, Henriette Ya Kissi, Anthony Afum-Adjei Awuah, Aboubacar Demba Bangoura, Stanislas Adjeka Doffou, Alain Koffi Attia
Background: Systemic inflammatory response syndrome (SIRS) and model for end-stage liver disease (MELD) predict short-term mortality in patients with cirrhosis. Prediction of mortality at initial hospitalization is unknown in black African patients with decompensated cirrhosis. Aim: This study aimed to look at the role of MELD score and SIRS as the predictors of morbidity and mortality at initial hospitalization. Patients and methods: In this retrospective cohort study, we enrolled 159 patients with cirrhosis (median age: 49 years, 70...
2018: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29661461/urgent-living-donor-liver-transplantation-in-a-patient-with-concurrent-active-tuberculosis-a-case-report
#12
B-H Jung, J-I Park, S-G Lee
BACKGROUND: Although active tuberculosis (TB) is considered a contraindication for liver transplantation (LT), this is the only treatment in patients with liver failure and concurrent active TB. We report a case with successful urgent living-donor LT for irreversible liver failure in the presence of active TB. CASE PRESENTATION: A 48-year-old man, with a history of decompensated alcoholic liver cirrhosis, was presented with stupor. At admission, his consciousness had deteriorated to semi-coma, and his renal function also rapidly deteriorated to hepatorenal syndrome...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29655999/ovarian-hyperstimulation-syndrome-leading-to-ventriculoperitoneal-shunt-malfunction-case-report
#13
Amit Azriel, Benjamin Fleming, Uri P Dior, Samuel Moscovici, Yuval Sufaro, Mohammed Awad, Kate Drummond
Ventriculoperitoneal shunt (VPS) insertion is a common neurosurgical procedure for hydrocephalus. Unfortunately, VPS malfunction is not uncommon, with an estimated cumulative rate of 32% at 5 years. As flow through the shunt is influenced by the pressure gradient between the ventricles and the peritoneal cavity, malfunction may be caused by elevated intra-abdominal pressure. We present a rare patient with ascites following ovarian hyperstimulation syndrome (OHSS) leading to shunt malfunction. OHSS is a potentially life-threatening complication of controlled ovarian stimulation caused by the administration of exogenous gonadotropins...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29629873/a-maternally-sequestered-biopolymer-stabilized-vascular-endothelial-growth-factor-vegf-chimera-for-treatment-of-preeclampsia
#14
Omar C Logue, Fakhri Mahdi, Heather Chapman, Eric M George, Gene L Bidwell
BACKGROUND: Preeclampsia is a hypertensive syndrome that complicates 3% to 5% of pregnancies in the United States. Preeclampsia originates from an improperly vascularized and ischemic placenta that releases factors that drive systemic pathophysiology. One of these factors, soluble fms-like tyrosine kinase-1, is believed to sequester vascular endothelial growth factor (VEGF), leading to systemic endothelial dysfunction and hypertension. With the goal of targeting soluble fms-like tyrosine kinase-1 while simultaneously preventing fetal exposure to VEGF, we fused VEGF to elastin-like polypeptide, a biopolymer carrier that does not cross the placental barrier (ELP-VEGF)...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29625879/tivantinib-for-second-line-treatment-of-met-high-advanced-hepatocellular-carcinoma-metiv-hcc-a-final-analysis-of-a-phase-3-randomised-placebo-controlled-study
#15
Lorenza Rimassa, Eric Assenat, Markus Peck-Radosavljevic, Marc Pracht, Vittorina Zagonel, Philippe Mathurin, Elena Rota Caremoli, Camillo Porta, Bruno Daniele, Luigi Bolondi, Vincenzo Mazzaferro, William Harris, Nevena Damjanov, Davide Pastorelli, María Reig, Jennifer Knox, Francesca Negri, Jörg Trojan, Carlos López López, Nicola Personeni, Thomas Decaens, Marie Dupuy, Wolfgang Sieghart, Giovanni Abbadessa, Brian Schwartz, Maria Lamar, Terri Goldberg, Dale Shuster, Armando Santoro, Jordi Bruix
BACKGROUND: Tivantinib (ARQ 197), a selective, oral MET inhibitor, improved overall survival and progression-free survival compared with placebo in a randomised phase 2 study in patients with high MET expression (MET-high) hepatocellular carcinoma previously treated with sorafenib. The aim of this phase 3 study was to confirm the results of the phase 2 trial. METHODS: We did a phase 3, randomised, double-blind, placebo-controlled study in 90 centres in Australia, the Americas, Europe, and New Zealand...
April 3, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29611656/the-effect-of-acetylosalicylic-acid-and-berberis-on-ascites-syndrome-parameters-in-broiler-chickens
#16
M Hormozi, M Jahantigh, M Jahantigh
One-hundred and thirty day-old broiler chickens were kept for 6 days and on the seventh day, 120 chickens were selected and randomly divided into 5 groups with 2 replicates. To cause ascites, an amount of 0.12% sodium was added to the drinking water of 4 groups of chickens. On the fourteenth day, the amount of sodium was increased to 0.24% and at the same time, treatment with acetylosalicylic acid and berberis was started. At the age of 14 and 21 days, random sample chickens from each replicate were necropsied and were examined in terms of the factors associated with ascites...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29587657/effective-treatment-of-apatinib-in-desmoplastic-small-round-cell-tumor-a-case-report-and-literature-review
#17
Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan, Lu Pan
BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare malignant sarcoma with poor prognosis due to lack of effective treatments. Apatinib is a new potent oral small-molecule tyrosine kinase inhibitor, and targets the intracellular domain of vascular endothelial growth factor receptor 2 (VEGFR-2). In this study, we presented a case of intra-abdominal DSRCT which was effectively treated by apatinib. CASE PRESENTATION: A 32-year-old man was admitted due to increasing urination frequency and palpable mass in right lower abdomen for 2 months...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29580081/pulmonary-hypertensive-response-of-broiler-chickens-to-arginine-and-guanidinoacetic-acid-under-high-altitude-hypoxia
#18
Behnam Ahmadipour, Mohammadreza Sharifi, Fariborz Khajali
This study assessed the preventive effects of arginine (ARG) and guanidinoacetic acid (GAA) on the incidence of pulmonary hypertension syndrome (PHS) in broiler chickens. Four isoenergetic and isonitrogenous diets were prepared, including: (i) the control, (ii) the control supplemented with 1 g/kg ARG, (iii) the control supplemented with 1 g/kg GAA, and (iv) the control supplemented with 1.5 g/kg GAA. These diets were fed to broilers (Ross 308) from day 1 to 42 post-hatch. Criteria evaluated in the experiment were growth performance, carcass characteristics, serum and blood variables, lead-II electrocardiogram, and ET-1 and iNOS gene expression in heart and lungs...
March 2018: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/29558895/fitz-hugh-curtis-syndrome-associated-with-tuberculous-salpingitis-and-peritonitis-a-case-presentation-and-review-of-literature
#19
Laura Coremans, Frederik de Clerck
BACKGROUND: Fitz-Hugh-Curtis syndrome or acute perihepatitis is considered a rare complication of pelvic inflammatory disease, mostly associated with chlamydial or gonococcal salpingitis. Peritoneal tuberculosis is a rare site of extra-pulmonary infection caused by Mycobacterium tuberculosis. Infection usually occurs after reactivation of latent tuberculous foci in the peritoneum and more seldom after contiguous spread from tuberculous salpingitis. CASE PRESENTATION: We describe a case of a 21-year old female of Somalian origin diagnosed with Fitz-Hugh Curtis syndrome associated with tuberculous salpingitis and peritonitis, presenting with new onset ascites...
March 20, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29532591/un-precipitated-acute-kidney-injury-is-uncommon-among-stable-patients-with-cirrhosis-and-ascites
#20
Florence Wong, Peter Jepsen, Hugh Watson, Hendrik Vilstrup
BACKGROUND & AIMS: Acute episodes of renal dysfunction or acute kidney injury (AKI) in cirrhotic patients with ascites are mostly precipitated by an acute event. The prevalence of un-precipitated AKI in stable ascitic cirrhotic patients is unknown. The aims of this study were to determine (i) the prevalence of un-precipitated AKI in stable cirrhotics with ascites and (ii) any predictive factors for its development. METHODS: A total of 1115 stable cirrhotic patients with mild liver and renal dysfunction but varying degrees of ascites severity from 3 previous satavaptan vs placebo randomized controlled trials (Group A, ascites requiring diuretics but not paracentesis; Group B, ascites requiring frequent paracentesis; Group C, refractory ascites) were included...
March 13, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
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