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https://www.readbyqxmd.com/read/28079768/interpregnancy-interval-after-termination-of-pregnancy-and-the-risks-of-adverse-outcomes-in-subsequent-birth
#1
Jaana Männistö, Aini Bloigu, Mika Gissler, Oskari Heikinheimo, Maarit Niinimäki
OBJECTIVE: To assess whether the length of the interpregnancy interval after termination of pregnancy influences the risk of preterm birth, low birth weight, and small-for-gestational-age neonates in a subsequent pregnancy. METHODS: In this register-based study, we included all women (N=19,894) who underwent termination of pregnancy between 2000 and 2009 and whose subsequent pregnancy ended in live singleton delivery. The women were divided into five groups depending on the interpregnancy interval between termination of pregnancy and subsequent conception: interpregnancy interval less than 6 months (n=2,956), 6 to less than 12 months (n=3,203), 12 to less than 18 months (n=2,623), 18 to less than 24 months (n=2,076), and 24 months or greater (n=9,036)...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28057878/pseudoautosomal-abnormalities-in-terminal-azfb-c-deletions-are-associated-with-isochromosomes-yp-and-may-lead-to-abnormal-growth-and-neuropsychiatric-function
#2
A Castro, F Rodríguez, M Flórez, P López, B Curotto, D Martínez, A Maturana, M C Lardone, C Palma, V Mericq, M Ebensperger, F Cassorla
STUDY QUESTION: Are copy number variations (CNVs) in the pseudoautosomal regions (PARs) frequent in subjects with Y-chromosome microdeletions and can they lead to abnormal stature and/or neuropsychiatric disorders? SUMMARY ANSWER: Only subjects diagnosed with azoospermia factor (AZF)b+c deletions spanning to the end of the Y chromosome (i.e. terminal deletions) harbor Y isochromosomes and/or cells 45,X that lead to pseudoautosomal gene CNVs, which were associated with abnormal stature and/or neuropsychiatric disorders...
January 5, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28011903/safety-and-efficacy-of-obinutuzumab-with-chop-or-bendamustine-in-previously-untreated-follicular-lymphoma
#3
Andrew Grigg, Martin J S Dyer, Marcos González Díaz, Martin Dreyling, Simon Rule, Guiyuan Lei, Andrea Knapp, Elisabeth Wassner-Fritsch, Paula Marlton
The GAUDI study assessed safety and preliminary efficacy of induction therapy with obinutuzumab plus chemotherapy, followed by maintenance with obinutuzumab alone, in previously untreated patients with follicular lymphoma. Assignment to chemotherapy was decided on a per center basis before patient enrollment. Patients (n=81) received 4-6 cycles of obinutuzumab plus bendamustine every 4 weeks or 6-8 cycles of obinutuzumab plus CHOP every 3 weeks. Patients with an end-of-treatment response were eligible for obinutuzumab maintenance therapy every 3 months for 2 years or until disease progression...
December 23, 2016: Haematologica
https://www.readbyqxmd.com/read/27936067/deletion-at-the-gcnt2-locus-causes-autosomal-recessive-congenital-cataracts
#4
Bushra Irum, Shahid Y Khan, Muhammad Ali, Muhammad Daud, Firoz Kabir, Bushra Rauf, Fareeha Fatima, Hira Iqbal, Arif O Khan, Saif Al Obaisi, Muhammad Asif Naeem, Idrees A Nasir, Shaheen N Khan, Tayyab Husnain, Sheikh Riazuddin, Javed Akram, Allen O Eghrari, S Amer Riazuddin
PURPOSE: The aim of this study is to identify the molecular basis of autosomal recessive congenital cataracts (arCC) in a large consanguineous pedigree. METHODS: All participating individuals underwent a detailed ophthalmic examination. Each patient's medical history, particularly of cataracts and other ocular abnormalities, was compiled from available medical records and interviews with family elders. Blood samples were donated by all participating family members and used to extract genomic DNA...
2016: PloS One
https://www.readbyqxmd.com/read/27908704/on-the-relationship-between-cell-cycle-analysis-with-ergodic-principles-and-age-structured-cell-population-models
#5
K Kuritz, D Stöhr, N Pollak, F Allgöwer
Cyclic processes, in particular the cell cycle, are of great importance in cell biology. Continued improvement in cell population analysis methods like fluorescence microscopy, flow cytometry, CyTOF or single-cell omics made mathematical methods based on ergodic principles a powerful tool in studying these processes. In this paper, we establish the relationship between cell cycle analysis with ergodic principles and age structured population models. To this end, we describe the progression of a single cell through the cell cycle by a stochastic differential equation on a one dimensional manifold in the high dimensional dataspace of cell cycle markers...
November 28, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27846997/safety-compliance-and-safety-climate-a-repeated-cross-sectional-study-in-the-oil-and-gas-industry
#6
Sverre A Kvalheim, Øyvind Dahl
INTRODUCTION: Violations of safety rules and procedures are commonly identified as a causal factor in accidents in the oil and gas industry. Extensive knowledge on effective management practices related to improved compliance with safety procedures is therefore needed. Previous studies of the causal relationship between safety climate and safety compliance demonstrate that the propensity to act in accordance with prevailing rules and procedures is influenced to a large degree by workers' safety climate...
December 2016: Journal of Safety Research
https://www.readbyqxmd.com/read/27845678/deep-logic-networks-inserting-and-extracting-knowledge-from-deep-belief-networks
#7
Son N Tran, Artur S d'Avila Garcez
Developments in deep learning have seen the use of layerwise unsupervised learning combined with supervised learning for fine-tuning. With this layerwise approach, a deep network can be seen as a more modular system that lends itself well to learning representations. In this paper, we investigate whether such modularity can be useful to the insertion of background knowledge into deep networks, whether it can improve learning performance when it is available, and to the extraction of knowledge from trained deep networks, and whether it can offer a better understanding of the representations learned by such networks...
November 8, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27835985/hypoxia-response-in-arabidopsis-roots-infected-by-plasmodiophora-brassicae-supports-the-development-of-clubroot
#8
Antoine Gravot, Gautier Richard, Tanguy Lime, Séverine Lemarié, Mélanie Jubault, Christine Lariagon, Jocelyne Lemoine, Jorge Vicente, Alexandre Robert-Seilaniantz, Michael J Holdsworth, Maria J Manzanares-Dauleux
BACKGROUND: The induction of alcohol fermentation in roots is a plant adaptive response to flooding stress and oxygen deprivation. Available transcriptomic data suggest that fermentation-related genes are also frequently induced in roots infected with gall forming pathogens, but the biological significance of this induction is unclear. In this study, we addressed the role of hypoxia responses in Arabidopsis roots during infection by the clubroot agent Plasmodiophora brassicae. RESULTS: The hypoxia-related gene markers PYRUVATE DECARBOXYLASE 1 (PDC1), PYRUVATE DECARBOXYLASE 2 (PDC2) and ALCOHOL DEHYDROGENASE 1 (ADH1) were induced during secondary infection by two isolates of P...
November 11, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27833930/prognostic-value-of-transient-elastography-in-human-immunodeficiency-virus-infected-patients-with-chronic-hepatitis-c
#9
Leire Pérez-Latorre, Antonio Rivero-Juárez, Víctor Hontañón, Cristina Díez, Francisca Cuenca, Maria Luz Martín-Carbonero, María L Montes, José M Bellón, Teresa Aldámiz-Echevarría, Ana Carrero, Antonio Rivero, Juan González-García, Juan Berenguer
BACKGROUND: Our objective was to study the prognostic value of liver stiffness (LS) in HIV-infected patients with chronic hepatitis C (CHC). METHODS: We analyzed HIV-infected patients with compensated CHC and at least 1 determination of LS. The primary outcome was the occurrence of liver-related events (LRE), namely, decompensation or hepatocellular carcinoma, whichever occurred first. We selected patients without sustained viral response (SVR) or end-of-treatment response (ETR) during follow-up and allocated them to an estimation cohort (EC) and a validation cohort (VC)...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27830050/the-presence-of-the-ancestral-insect-telomeric-motif-in-kissing-bugs-triatominae-rules-out-the-hypothesis-of-its-loss-in-evolutionarily-advanced-heteroptera-cimicomorpha
#10
Sebastián Pita, Francisco Panzera, Pablo Mora, Jesús Vela, Teresa Palomeque, Pedro Lorite
Next-generation sequencing data analysis on Triatoma infestans Klug, 1834 (Heteroptera, Cimicomorpha, Reduviidae) revealed the presence of the ancestral insect (TTAGG)n telomeric motif in its genome. Fluorescence in situ hybridization confirms that chromosomes bear this telomeric sequence in their chromosomal ends. Furthermore, motif amount estimation was about 0.03% of the total genome, so that the average telomere length in each chromosomal end is almost 18 kb long. We also detected the presence of (TTAGG)n telomeric repeat in mitotic and meiotic chromosomes in other three species of Triatominae: Triatoma dimidiata Latreille, 1811, Dipetalogaster maxima Uhler, 1894, and Rhodnius prolixus Ståhl, 1859...
2016: Comparative Cytogenetics
https://www.readbyqxmd.com/read/27791147/structural-basis-for-dual-specificity-of-yeast-n-terminal-amidase-in-the-n-end-rule-pathway
#11
Min Kyung Kim, Sun Joo Oh, Byung-Gil Lee, Hyun Kyu Song
The first step of the hierarchically organized Arg/N-end rule pathway of protein degradation is deamidation of the N-terminal glutamine and asparagine residues of substrate proteins to glutamate and aspartate, respectively. These reactions are catalyzed by the N-terminal amidase (Nt-amidase) Nta1 in fungi such as Saccharomyces cerevisiae, and by the glutamine-specific Ntaq1 and asparagine-specific Ntan1 Nt-amidases in mammals. To investigate the dual specificity of yeast Nta1 (yNta1) and the importance of second-position residues in Asn/Gln-bearing N-terminal degradation signals (N-degrons), we determined crystal structures of yNta1 in the apo state and in complex with various N-degron peptides...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27779507/professionalism-in-the-twilight-zone-a-multicenter-mixed-methods-study-of-shift-transition-dynamics-in-surgical-residencies
#12
James E Coverdill, Adnan Alseidi, David C Borgstrom, Daniel L Dent, Russell D Dumire, Jonathan Fryer, Thomas H Hartranft, Steven B Holsten, M Timothy Nelson, Mohsen Shabahang, Stanley Sherman, Paula M Termuhlen, Randy J Woods, John D Mellinger
PURPOSE: Duty hours rules sparked debates about professionalism. This study explores whether and why general surgery residents delay departures at the end of a day shift in ways consistent with shift work, traditional professionalism, or a new professionalism. METHOD: Questionnaires were administered to categorical residents in 13 general surgery programs in 2014 and 2015. The response rate was 76% (N = 291). The 18 items focused on end-of-shift behaviors and the frequency and source of delayed departures...
November 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/27710437/influence-of-football-size-on-kicking-performance-in-youth-australian-rules-footballers
#13
Stephen M Hadlow, Ross A Pinder, Mark G L Sayers
In Australian rules football structured increases in ball size during development end with the transition to the Size 5 (adult) ball at the Under-15 age group. This study assessed changes in kick technique and performance in experienced junior performers when using Size 4 and 5 Australian rules footballs. Participants (n = 22, 13.77 ± 0.61 years) performed drop punt kicks in 2 representative tasks; a Decision-Making Test (DMT) (n = 14) and Set-Shot Test (SST) (n = 14 + 8). Results indicate participants sustained their level of kick performance (accuracy and quality of ball spin) in both tests when using a Size 5 football...
October 6, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27672116/home-based-rehabilitation-for-copd-using-minimal-resources-a-randomised-controlled-equivalence-trial
#14
Anne E Holland, Ajay Mahal, Catherine J Hill, Annemarie L Lee, Angela T Burge, Narelle S Cox, Rosemary Moore, Caroline Nicolson, Paul O'Halloran, Aroub Lahham, Rebecca Gillies, Christine F McDonald
BACKGROUND: Pulmonary rehabilitation is a cornerstone of care for COPD but uptake of traditional centre-based programmes is poor. We assessed whether home-based pulmonary rehabilitation, delivered using minimal resources, had equivalent outcomes to centre-based pulmonary rehabilitation. METHODS: A randomised controlled equivalence trial with 12 months follow-up. Participants with stable COPD were randomly assigned to receive 8 weeks of pulmonary rehabilitation by either the standard outpatient centre-based model, or a new home-based model including one home visit and seven once-weekly telephone calls from a physiotherapist...
January 2017: Thorax
https://www.readbyqxmd.com/read/27639966/substitutions-of-amino-acids-with-large-number-of-contacts-in-the-native-state-have-no-effect-on-the-rates-of-protein-folding
#15
Bogdan S Melnik, Galina S Nagibina, Anatoly S Glukhov, Tatiana N Melnik, Vladimir N Uversky
Various effects of amino acid substitutions on properties of globular proteins have been described in a large number of research papers. Nevertheless, no definite "rule" has been formulated as of yet that could be used by experimentalists to introduce desirable changes in the properties of proteins. Herein we attempt to establish such a "rule". To this end, a hypothesis is proposed on the effects of substitutions of hydrophobic residues with large number of contacts on free energies of different states of a globular protein...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27614019/dpp9-is-a-novel-component-of-the-n-end-rule-pathway-targeting-the-tyrosine-kinase-syk
#16
Daniela Justa-Schuch, Maria Silva-Garcia, Esther Pilla, Michael Engelke, Markus Kilisch, Christof Lenz, Ulrike Möller, Fumihiko Nakamura, Henning Urlaub, Ruth Geiss-Friedlander
The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in second position. Although linked to several pathways including cell survival and metabolism, the molecular mechanisms underlying these outcomes are poorly understood. We identified a novel interaction of DPP9 with Filamin A, which recruits DPP9 to Syk, a central kinase in B-cell signalling. Syk signalling can be terminated by degradation, requiring the ubiquitin E3 ligase Cbl. We show that DPP9 cleaves Syk to produce a neo N-terminus with serine in position 1...
September 10, 2016: ELife
https://www.readbyqxmd.com/read/27601470/phosphorylation-impacts-n-end-rule-degradation-of-the-proteolytically-activated-form-of-bmx-kinase
#17
Mohamed A Eldeeb, Richard P Fahlman
Cellular signaling leading to the initiation of apoptosis typically results in the activation of caspases, which in turn leads to the proteolytic generation of protein fragments with new or altered cellular functions. Increasing numbers of reports are demonstrating that the activity of many of these proteolytically activated protein fragments can be attenuated by their selective degradation by the N-end rule pathway. Here we report the first evidence that selective degradation of a caspase product by the N-end rule pathway can be modulated by phosphorylation...
October 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27599328/effect-of-bevacizumab-nasal-spray-on-epistaxis-duration-in-hereditary-hemorrhagic-telangectasia-a-randomized-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Sophie Dupuis-Girod, Alexis Ambrun, Evelyne Decullier, Anne-Emmanuelle Fargeton, Adeline Roux, Valentine Bréant, Bettina Colombet, Sophie Rivière, César Cartier, Pascal Lacombe, Thierry Chinet, Sandra Blivet, Jean-Hugues Blondel, Brigitte Gilbert-Dussardier, Xavier Dufour, Justin Michel, Jean-Robert Harle, Patrick Dessi, Frédéric Faure
BACKGROUND: Epistaxis is the most frequent and disabling manifestation of hereditary hemorrhagic telangiectasia (HHT). The efficacy of intravenous bevacizumab (an anti-vascular endothelial growth factor monoclonal antibody) for epistaxis has been shown. However, the efficacy of intranasal bevacizumab has yet to be evaluated. OBJECTIVE: To evaluate the efficacy of 3 different doses of bevacizumab administered as a nasal spray in a repeated manner for the duration of nosebleeds in patients with HHT...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27581713/morad6-mediated-ubiquitination-pathways-are-essential-for-development-and-pathogenicity-in-magnaporthe-oryzae
#19
Huan-Bin Shi, Guo-Qing Chen, Ya-Ping Chen, Bo Dong, Jian-Ping Lu, Xiao-Hong Liu, Fu-Cheng Lin
The ubiquitin system modulates protein functions through targeting substrates for ubiquitination. Here, E2 conjugating enzyme MoRad6-related ubiquitination pathways are identified and analyzed in Magnaporthe oryzae, the causal agent of rice blast disease. Disruption of MoRad6 leads to severe defects in growth, sporulation, conidial germination, appressorium formation, and plant infection. To depict the functions of MoRad6, three putative ubiquitin ligases, MoRad18, MoBre1 and MoUbr1, are also characterized...
November 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27560450/the-arginylation-branch-of-the-n-end-rule-pathway-positively-regulates-cellular-autophagic-flux-and-clearance-of-proteotoxic-proteins
#20
Yanxialei Jiang, Jeeyoung Lee, Jung Hoon Lee, Joon Won Lee, Ji Hyeon Kim, Won Hoon Choi, Young Dong Yoo, Hyunjoo Cha-Molstad, Bo Yeon Kim, Yong Tae Kwon, Sue Ah Noh, Kwang Pyo Kim, Min Jae Lee
The N-terminal amino acid of a protein is an essential determinant of ubiquitination and subsequent proteasomal degradation in the N-end rule pathway. Using para-chloroamphetamine (PCA), a specific inhibitor of the arginylation branch of the pathway (Arg/N-end rule pathway), we identified that blocking the Arg/N-end rule pathway significantly impaired the fusion of autophagosomes with lysosomes. Under ER stress, ATE1-encoded Arg-tRNA-protein transferases carry out the N-terminal arginylation of the ER heat shock protein HSPA5 that initially targets cargo proteins, along with SQSTM1, to the autophagosome...
November 2016: Autophagy
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