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N-end rule

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https://www.readbyqxmd.com/read/29662186/understanding-the-pro-n-end-rule-pathway
#1
David A Dougan, Alexander Varshavsky
No abstract text is available yet for this article.
May 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29649399/a-rules-based-algorithm-to-prioritize-poor-prognosis-cancer-patients-in-need-of-advance-care-planning
#2
Christine M Bestvina, Kristen E Wroblewski, Bobby Daly, Brittany Beach, Selina Chow, Andrew Hantel, Monica Malec, Michael T Huber, Blase N Polite
BACKGROUND: Accurate understanding of the prognosis of an advanced cancer patient can lead to decreased aggressive care at the end of life and earlier hospice enrollment. OBJECTIVE: Our goal was to determine the association between high-risk clinical events identified by a simple, rules-based algorithm and decreased overall survival, to target poor prognosis cancer patients who would urgently benefit from advanced care planning. DESIGN: A retrospective analysis was performed on outpatient oncology patients with an index visit from April 1, 2015, through June 30, 2015...
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29649217/the-ubr-1-ubiquitin-ligase-regulates-glutamate-metabolism-to-generate-coordinated-motor-pattern-in-caenorhabditis-elegans
#3
Jyothsna Chitturi, Wesley Hung, Anas M Abdel Rahman, Min Wu, Maria A Lim, John Calarco, Renee Baran, Xun Huang, James W Dennis, Mei Zhen
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C. elegans UBR-1 leads to a specific motor deficit: when adult animals generate reversal movements, A-class motor neurons exhibit synchronized activation, preventing body bending. This motor deficit is rescued by removing GOT-1, a transaminase that converts aspartate to glutamate...
April 12, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29563649/ocean-acidification-and-desalination-climate-driven-change-in-a-baltic-sea-summer-microplanktonic-community
#4
Angela Wulff, Maria Karlberg, Malin Olofsson, Anders Torstensson, Lasse Riemann, Franciska S Steinhoff, Malin Mohlin, Nina Ekstrand, Melissa Chierici
Helcom scenario modelling suggests that the Baltic Sea, one of the largest brackish-water bodies in the world, could expect increased precipitation (decreased salinity) and increased concentration of atmospheric CO2 over the next 100 years. These changes are expected to affect the microplanktonic food web, and thereby nutrient and carbon cycling, in a complex and possibly synergistic manner. In the Baltic Proper, the extensive summer blooms dominated by the filamentous cyanobacteria Aphanizomenon sp., Dolichospermum spp...
2018: Marine Biology
https://www.readbyqxmd.com/read/29541932/hsv-1-encoded-microrna-mir-h1-targets-ubr1-to-promote-accumulation-of-neurodegeneration-associated-protein
#5
Kai Zheng, Qiuying Liu, Shaoxiang Wang, Zhe Ren, Kaio Kitazato, Depo Yang, Yifei Wang
Herpes simplex virus 1 (HSV-1) encodes various microRNAs (miRNAs), whose targets are largely unknown. miR-H1 is the first discovered HSV-1 miRNA and is expressed predominantly in productive infection. Here we show that ubiquitin protein ligase E3 component n-recognin 1 (Ubr1) is a cellular target of miR-H1. Ubr1 is a RING-type E3 ubiquitin ligase of the Arg/N-end rule pathway, which causes the degradation of proteins bearing "destabilizing" N-terminal residues, such as neurodegeneration-associated protein fragment β-amyloid...
March 14, 2018: Virus Genes
https://www.readbyqxmd.com/read/29516883/a-comparison-of-intradermal-test-with-recombinant-tuberculosis-allergen-diaskintest-with-other-immunologic-tests-in-the-diagnosis-of-tuberculosis-infection
#6
Anna Starshinova, Viacheslav Zhuravlev, Irina Dovgaluk, Alexandr Panteleev, Vera Manina, Ulia Zinchenko, Evgenia Istomina, Maria Pavlova, Piotr Yablonskiy
Background: The WHO strategy for eradication of tuberculosis (TB) by 2035 (The End TB Strategy) is aimed at an early and precise diagnosis and subsequent effective treatment of TB patients. Currently, there is no gold standard for the diagnosis of latent TB infection. This study evaluated the diagnostic capabilities of a new intradermal test using recombinant TB allergen (Diaskintest) compared with tuberculin skin test (TST) and commercial TB interferon-gamma release assays (IGRAs). Methods: A post-hoc data analysis that involved examining 860 HIV-negative, bacillus Calmette-Guérin (BCG)-vaccinated persons aged 1-65 years who visited the TB health-care institutions of Saint Petersburg to rule out or confirm an active TB was conducted from 2011 to 2016...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29507222/n-terminal-arginylation-generates-a-bimodal-degron-that-modulates-autophagic-proteolysis
#7
Young Dong Yoo, Su Ran Mun, Chang Hoon Ji, Ki Woon Sung, Keum Young Kang, Ah Jung Heo, Su Hyun Lee, Jee Young An, Joonsung Hwang, Xiang-Qun Xie, Aaron Ciechanover, Bo Yeon Kim, Yong Tae Kwon
The conjugation of amino acids to the protein N termini is universally observed in eukaryotes and prokaryotes, yet its functions remain poorly understood. In eukaryotes, the amino acid l-arginine (l-Arg) is conjugated to N-terminal Asp (Nt-Asp), Glu, Gln, Asn, and Cys, directly or associated with posttranslational modifications. Following Nt-arginylation, the Nt-Arg is recognized by UBR boxes of N-recognins such as UBR1, UBR2, UBR4/p600, and UBR5/EDD, leading to substrate ubiquitination and proteasomal degradation via the N-end rule pathway...
March 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29401302/a-gatekeeper-residue-of-clps1-from-arabidopsis-thaliana-chloroplasts-determines-its-affinity-towards-substrates-of-the-bacterial-n-end-rule
#8
Clara V Colombo, Germán L Rosano, Axel Mogk, Eduardo A Ceccarelli
Proteins that are to be eliminated must be proficiently recognized by proteolytic systems so that inadvertent elimination of useful proteins is avoided. One mechanism to ensure proper recognition is the presence of N-terminal degradation signals (N-degrons) that are targeted by adaptor proteins (N-recognins). The members of the ClpS family of N-recognins identify targets bearing an N-terminal phenylalanine, tyrosine, tryptophan or leucine residue and then, present them to a protease system. This process is known as the "bacterial N-end rule...
February 1, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29386393/identification-of-wiskott-aldrich-syndrome-protein-wasp-binding-sites-on-the-branched-actin-filament-nucleator-arp2-3-complex
#9
Qing Luan, Alex Zelter, Michael J MacCoss, Trisha N Davis, Brad J Nolen
Arp2/3 complex nucleates branched actin filaments important for cellular motility and endocytosis. WASP family proteins are Arp2/3 complex activators that play multiple roles in branching nucleation, but little is known about the structural bases of these WASP functions, owing to an incomplete understanding of how WASP binds Arp2/3 complex. Recent data show WASP binds two sites, and biochemical and structural studies led to models in which the WASP C segment engages the barbed ends of the Arp3 and Arp2 subunits while the WASP A segment binds the back side of the complex on Arp3...
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29345112/low-nt-probnp-levels-in-overweight-and-obese-patients-do-not-rule-out-a-diagnosis-of-heart-failure-with-preserved-ejection-fraction
#10
Leo F Buckley, Justin M Canada, Marco G Del Buono, Salvatore Carbone, Cory R Trankle, Hayley Billingsley, Dinesh Kadariya, Ross Arena, Benjamin W Van Tassell, Antonio Abbate
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that presents clinicians with a diagnostic challenge. The use of natriuretic peptides to exclude a diagnosis of HFpEF has been proposed. We sought to compare HFpEF patients with N-terminal pro-brain natriuretic peptide (NT-proBNP) level above and below the proposed cut-off. METHODS: Stable patients (n = 30) with left ventricular (LV) ejection fraction ≥ 50% were eligible if they had a diagnosis of HF according to the European Society of Cardiology diagnostic criteria...
January 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29319709/displacement-of-%C3%AE-5-cyclopentadienyl-ligands-from-half-sandwich-c-c-nhc-cyanoalkyl-nickel-ii-metallacycles-further-insight-into-the-structure-of-the-resulting-cp-free-nickelacycles-and-a-catalytic-activity-study
#11
Bernardo de P Cardoso, Jean-Marie Bernard-Schaaf, Saurabh Shahane, Luis F Veiros, Michael J Chetcuti, Vincent Ritleng
Four cationic C,C-(NHC-cyanoalkyl)-nickel(ii) metallacyclic complexes, [Ni{Me-NHC-CH2 CH(CN)}(NCMe)](PF6 ) (2a), [Ni{Mes-NHC-CH2 CH(CN)}(NCMe)](PF6 ) (2b), [Ni{Mes-NHC-(CH2 )2 CH(CN)}(NCMe)](PF6 ) (2c) and [Ni{DiPP-NHC-(CH2 )2 CH(CN)}(NCMe)](PF6 ) (2d), were prepared by the removal of the Cp ligand under acidic conditions at 0 °C from the corresponding half-sandwich nickelacycles [NiCp{R-NHC-(CH2 )n CH(CN)}] (1a-1d; Cp = η5 -C5 H5 ; n = 1 or 2; R-NHC-(CH2 )n CH(CN) = 1-R-3-[(CH2 )n CH(CN)]-imidazol-2-ylidene)...
January 30, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29301968/engineering-posttranslational-proofreading-to-discriminate-nonstandard-amino-acids
#12
Aditya M Kunjapur, Devon A Stork, Erkin Kuru, Oscar Vargas-Rodriguez, Matthieu Landon, Dieter Söll, George M Church
Incorporation of nonstandard amino acids (nsAAs) leads to chemical diversification of proteins, which is an important tool for the investigation and engineering of biological processes. However, the aminoacyl-tRNA synthetases crucial for this process are polyspecific in regard to nsAAs and standard amino acids. Here, we develop a quality control system called "posttranslational proofreading" to more accurately and rapidly evaluate nsAA incorporation. We achieve this proofreading by hijacking a natural pathway of protein degradation known as the N-end rule, which regulates the lifespan of a protein based on its amino-terminal residue...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29301343/the-neonatal-intensive-care-unit-environmental-stressors-and-supports
#13
Kristen G Williams, Kayla T Patel, Julie M Stausmire, Christy Bridges, Mary W Mathis, Jennifer L Barkin
The relationship between maternal mental health and infant development has been established in the literature. The Neonatal Intensive Care Unit (NICU) is a particularly challenging environment for new mothers as several natural processes are disrupted. The objective of this study is to elucidate protective factors and environmental deficits associated with the NICU. The experiences of forty-six ( n = 46) mothers of infants admitted to a Level III NICU in the Midwestern United States, who responded to a related open-ended question, were analyzed thematically...
January 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29295953/the-endoplasmic-reticulum-residing-chaperone-bip-is-short-lived-and-metabolized-through-n-terminal-arginylation
#14
Sang Mi Shim, Ha Rim Choi, Ki Woon Sung, Yoon Jee Lee, Sung Tae Kim, Daeho Kim, Su Ran Mun, Joonsung Hwang, Hyunjoo Cha-Molstad, Aaron Ciechanover, Bo Yeon Kim, Yong Tae Kwon
BiP and other endoplasmic reticulum (ER)-resident proteins are thought to be metabolically stable and to function primarily in the ER lumen. We sought to assess how the abundance of these proteins dynamically fluctuates in response to various stresses and how their subpopulations are relocated to non-ER compartments such as the cytosol. We showed that the molecular chaperone BiP (also known as GRP78) was short-lived under basal conditions and ER stress. The turnover of BiP was in part driven by its amino-terminal arginylation (Nt-arginylation) by the arginyltransferase ATE1, which generated an autophagic N-degron of the N-end rule pathway...
January 2, 2018: Science Signaling
https://www.readbyqxmd.com/read/29284905/application-of-ethics-for-providing-telemedicine-services-and-information-technology
#15
REVIEW
Mostafa Langarizadeh, Fatemeh Moghbeli, Ali Aliabadi
Introduction: Advanced technology has increased the use of telemedicine and Information Technology (IT) in treating or rehabilitating diseases. An increased use of technology increases the importance of the ethical issues involved. The need for keeping patients' information confidential and secure, controlling a number of therapists' inefficiency as well as raising the quality of healthcare services necessitates adequate heed to ethical issues in telemedicine provision. Aim: The goal of this review is gathering all articles that are published through 5 years until now (2012-2017) for detecting ethical issues for providing telemedicine services and Information technology...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29275195/nitric-oxide-mediated-integrative-alterations-in-plant-metabolism-to-confer-abiotic-stress-tolerance-no-crosstalk-with-phytohormones-and-no-mediated-post-translational-modifications-in-modulating-diverse-plant-stress
#16
REVIEW
Fareen Sami, Mohammad Faizan, Ahmad Faraz, Husna Siddiqui, Mohammad Yusuf, Shamsul Hayat
Nitric oxide (NO) is a major signaling biomolecule associated with signal transduction in plants. The beneficial role of NO in plants, exposed to several abiotic stresses shifted our understanding as it being not only free radical, released from the toxic byproducts of oxidative metabolism but also helps in plant sustenance. An explosion of research in plant NO biology during the last two decades has revealed that NO is a key signal associated with plant growth, germination, photosynthesis, leaf senescence, pollen growth and reorientation...
February 28, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29261001/regulation-of-autophagic-proteolysis-by-the-n-recognin-sqstm1-p62-of-the-n-end-rule-pathway
#17
Hyunjoo Cha-Molstad, Su Hyun Lee, Jung Gi Kim, Ki Woon Sung, Joonsung Hwang, Sang Mi Shim, Srinivasrao Ganipisetti, Terry McGuire, Inhee Mook-Jung, Aaron Ciechanover, Xiang-Qun Xie, Bo Yeon Kim, Yong Tae Kwon
In macroautophagy/autophagy, cargoes are collected by specific receptors, such as SQSTM1/p62 (sequestosome 1), and delivered to phagophores for lysosomal degradation. To date, little is known about how cells modulate SQSTM1 activity and autophagosome biogenesis in response to accumulating cargoes. In this study, we show that SQSTM1 is an N-recognin whose ZZ domain binds N-terminal arginine (Nt-Arg) and other N-degrons (Nt-Lys, Nt-His, Nt-Trp, Nt-Phe, and Nt-Tyr) of the N-end rule pathway. The substrates of SQSTM1 include the endoplasmic reticulum (ER)-residing chaperone HSPA5/GRP78/BiP...
January 29, 2018: Autophagy
https://www.readbyqxmd.com/read/29235689/adduction-of-ammonium-to-polylactides-to-modify-their-dissociation-behavior-in-collision-induced-dissociation
#18
Christophe Chendo, Trang N T Phan, Marion Rollet, Didier Gigmes, Laurence Charles
RATIONALE: The goal of this work was to modify the dissociation pathways of polylactide (PLA) holding benzyl and hydroxyl terminations, in order to circumvent coincidence of product ions generated during collisional activation of sodiated chains, which prevented their reliable characterization. METHODS: Benzyl-, hydroxyl-terminated PLAs were ionized as ammonium adducts in positive ion mode electrospray and subjected to collision-induced dissociation (CID). Tandem mass spectrometry (MS/MS) experiments were conducted in a quadrupole time-of-flight (QTOF) instrument for safe assignment of product ions based on their elemental composition derived from accurate mass measurements...
March 15, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29233616/n-term-2017-proteostasis-via-the-n-terminus
#19
Nico Dissmeyer, Emmanuelle Graciet, Michael J Holdsworth, Daniel J Gibbs
N-term 2017 was the first international meeting to bring together researchers from diverse disciplines with a shared interest in protein N-terminal modifications and the N-end rule pathway of ubiquitin-mediated proteolysis, providing a platform for interdisciplinary cross-kingdom discussions and collaborations, as well as strengthening the visibility of this growing scientific community.
December 9, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/29231806/a-picorna-like-virus-suppresses-the-n-end-rule-pathway-to-inhibit-apoptosis
#20
Zhaowei Wang, Xiaoling Xia, Xueli Yang, Xueyi Zhang, Yongxiang Liu, Di Wu, Yuan Fang, Yujie Liu, Jiuyue Xu, Yang Qiu, Xi Zhou
The N-end rule pathway is an evolutionarily conserved proteolytic system that degrades proteins containing N-terminal degradation signals called N-degrons, and has emerged as a key regulator of various processes. Viruses manipulate diverse host pathways to facilitate viral replication and evade antiviral defenses. However, it remains unclear if viral infection has any impact on the N-end rule pathway. Here, using a picorna-like virus as a model, we found that viral infection promoted the accumulation of caspase-cleaved Drosophila inhibitor of apoptosis 1 (DIAP1) by inducing the degradation of N-terminal amidohydrolase 1 (NTAN1), a key N-end rule component that identifies N-degron to initiate the process...
December 12, 2017: ELife
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