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https://www.readbyqxmd.com/read/28091880/inhibition-of-neuronal-nitric-oxide-synthase-activity-does-not-alter-vasopressin-secretion-in-septic-rats
#1
Camila Henriques Coelho, Thalita Freitas Martins, Gabriela Ravanelli Oliveira-Pelegrin, Maria José Alves da Rocha
BACKGROUND/PURPOSE: During the early phase of sepsis, hypotension is accompanied by increase of plasma vasopressin hormone (AVP) levels, which decline during the late phase. This hypotension is due in part to increase of nitric oxide (NO) synthesis by nitric oxide synthase (NOS) enzyme. Neuronal isoform of this enzyme (nNOS) is present in vasopressinergics neurons of hypothalamus, but its role in vasopressin secretion during sepsis is unknown. METHODS: We evaluated the role of nNOS in NO production and vasopressin secretion during sepsis...
January 16, 2017: Pituitary
https://www.readbyqxmd.com/read/28090688/exosomal-mir-146a-contributes-to-the-enhanced-therapeutic-efficacy-of-il-1%C3%AE-primed-mesenchymal-stem-cells-against-sepsis
#2
Yuxian Song, Huan Dou, Xiujun Li, Xiaoyin Zhao, Yi Li, Dan Liu, Jianjian Ji, Fei Liu, Liang Ding, Yanhong Ni, Yayi Hou
Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through pretreatment with pro-inflammatory cytokines is an evolving field of investigation. However, the underlying mechanisms have not been fully clarified. Here, we pretreated human umbilical cord-derived MSCs with interleukin-1β (IL-1β) and evaluated their therapeutic effects in a cecal ligation and puncture (CLP)-induced sepsis model. We found that systemic administration of IL-1β-pretreated MSCs (βMSCs) ameliorated the symptoms of murine sepsis more effectively and increased the survival rate compared with naïve MSCs...
January 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28078551/the-proteolysis-adaptor-nbla-binds-to-the-n-terminus-of-%C3%AE-phycocyanin-implications-for-the-mechanism-of-phycobilisome-degradation
#3
Amelia Y Nguyen, William P Bricker, Hao Zhang, Daniel A Weisz, Michael L Gross, Himadri B Pakrasi
Phycobilisome (PBS) complexes are massive light-harvesting apparati in cyanobacteria that capture and funnel light energy to the photosystem. PBS complexes are dynamically degraded during nutrient deprivation, which causes severe chlorosis, and resynthesized during nutrient repletion. PBS degradation occurs rapidly after nutrient step down, and is specifically triggered by non-bleaching protein A (NblA), a small proteolysis adaptor that facilitates interactions between a Clp chaperone and phycobiliproteins...
January 11, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28073287/psychological-growth-and-well-being-in-individuals-born-with-cleft-an-application-of-self-determination-theory
#4
Aidan Searle, Patricia Neville, Andrea Waylen
OBJECTIVE: Many studies of individuals born with cleft lip and/or palate (CLP) address the psychological impact of CLP in terms of stigma and/or 'resilience'. The present study challenges the usefulness of resilience in CLP research with the application of self-determination theory (SDT). It is proposed that SDT can serve to better understand how individuals born with CLP can achieve psychological growth and well-being. DESIGN: Interviews were conducted with 15 individuals born with CLP in the UK...
January 10, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28068983/a-comparison-of-two-psychiatric-service-approaches-findings-from-the-consultation-vs-liaison-psychiatry-study
#5
Caroline Lücke, Jürgen M Gschossmann, Alena Schmidt, Juliane Gschossmann, Alexandra Philomena Lam, Charlotte Elizabeth Schneider, Alexandra Philipsen, Helge H Müller
BACKGROUND: Psychiatric comorbidities are common in somatically ill patients. There is a lack of data that can provide clear insights into substantial comparative advantages of different Consultation/Liaison Psychiatry (CLP) services. METHODS: The Consultation versus Liaison Psychiatry-Study collected and analyzed data of 890 primarily somatically ill hospital inpatients presenting with psychiatric symptoms in a prospective observational study design. One group was treated via a liaison-model (LM) with regular consultation hours, the other via an on-demand-model (ODM) with individually requested consultations...
January 10, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28067837/kaempferol-and-chrysin-synergies-to-improve-septic-mice-survival
#6
Omar A Harasstani, Chau Ling Tham, Daud A Israf
Previously, we reported the role of synergy between two flavonoids-namely, chrysin and kaempferol-in inhibiting the secretion of a few major proinflammatory mediators such as tumor necrosis factor-alpha (TNF-α), prostaglandin E₂ (PGE₂), and nitric oxide (NO) from lipopolysaccharide (LPS)-induced RAW 264.7 cells. The present study aims to evaluate the effects of this combination on a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Severe sepsis was induced in male ICR mice (n = 7) via the CLP procedure...
January 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28062623/a-novel-lipid-biomarker-panel-for-the-detection-of-heart-failure-with-reduced-ejection-fraction
#7
Matthias Mueller-Hennessen, Hans-Dirk Düngen, Matthias Lutz, Tobias Daniel Trippel, Michael Kreuter, Johanna Sigl, Oliver J Müller, Elvis Tahirovic, Henning Witt, Philipp Ternes, Susan Carvalho, Erik Peter, Dietrich Rein, Philipp Schatz, Felix Herth, Evangelos Giannitsis, Tanja Weis, Norbert Frey, Hugo A Katus
OBJECTIVES: In this study we aimed to identify novel metabolomic biomarkers suitable for improved diagnosis of heart failure with reduced ejection fraction (HFrEF). METHODS: We prospectively recruited 887 individuals consisting of HFrEF patients with either ischemic (ICMP, n = 257) or nonischemic cardiomyopathy (NICMP, n = 269), healthy controls (n = 327), and patients with pulmonary diseases (n = 34). A single-center identification (n = 238) was followed by a multicenter confirmation study (n = 649)...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28058672/neuroprotective-effects-of-intravenous-immunoglobulin-are-mediated-through-inhibition-of-complement-activation-and-apoptosis-in-a-rat-model-of-sepsis
#8
Figen Esen, Gunseli Orhun, Perihan Ergin Ozcan, Evren Senturk, Melike Kucukerden, Murat Giris, Ugur Akcan, Canan Ugur Yilmaz, Nurcan Orhan, Nadir Arican, Mehmet Kaya, Sema Bilgic Gazioglu, Erdem Tuzun
BACKGROUND: Intravenous (IV) immunoglobulin (Ig) treatment is known to alleviate behavioral deficits and increase survival in the experimentally induced model of sepsis. To delineate the mechanisms by which IVIg treatment prevents neuronal dysfunction, an array of immunological and apoptosis markers was investigated. METHODS: Sepsis was induced by cecal ligation perforation (CLP) in rats. The animals were divided into five groups: sham, control, CLP + saline, CLP + immunoglobulin G (IgG) (250 mg/kg, iv), and CLP + immunoglobulins enriched with immunoglobulin M (IgGAM) (250 mg/kg, iv)...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28038428/ghrelin-upregulates-pept1-activity-in-the-small-intestine-epithelium-of-rats-with-sepsis
#9
Jingquan Liu, Bin Shi, Kai Shi, Guoguang Ma, Hongze Zhang, Xiaoli Lou, Hongxiang Liu, Shengxia Wan, Dongyu Liang
BACKGROUND: Sepsis causes nutritional substrate malabsorption; hence, preventing gut barrier problems and improving the nutritional status in sepsis is a compelling issue. AIMS: We tested whether ghrelin administration affects peptide transporter 1 (PepT1) activity in the intestinal epithelium of rats with sepsis. METHODS: Sixty male Sprague-Dawley rats were randomly divided into sham-operated, sepsis, and ghrelin-treated groups. The cecum of sham-operated rats was separated after laparotomy without ligation and perforation...
December 27, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28035464/the-lipoxin-a4-agonist-bml-111-attenuates-acute-hepatic-dysfunction-induced-by-cecal-ligation-and-puncture-in-rats
#10
Ghada S El-Tanbouly, Mohammed S El-Awady, Nermeen A Megahed, Hassan A El-Kashef, Hatem A Salem
Sepsis is a systemic inflammatory response associating severe infection leading to multi-organ failure, such as hepatic dysfunction. This study investigates the possible hepatoprotective effect of the lipoxin A4 agonist (BML-111) in cecal ligation and puncture (CLP) model in rats. Pretreatment with BML-111 (1 mg/kg, i.p., 1 h before CLP) protected against CLP-induced mortality after 24 h. BML-111 prevented marked inflammatory cells in liver tissues and decreased elevation in serum hepatic biomarkers [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), gamma-glutamyl transferase (γ-GT)] induced by CLP...
December 29, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28031338/deletion-of-nlrp3-augments-survival-during-polymicrobial-sepsis-by-decreasing-autophagy-and-enhancing-phagocytosis
#11
Liliang Jin, Sanjay Batra, Samithamby Jeyaseelan
NLRP3 inflammasome is a critical player in innate immunity. Neutrophil recruitment to tissues and effective neutrophil function are critical innate immune mechanisms for bacterial clearance. However, the role of NLRP3 in neutrophil-dependent bacterial clearance in polymicrobial sepsis is unclear. In this study, we evaluated the role of NLRP3 in polymicrobial sepsis induced by cecal ligation and puncture (CLP). Our results showed protection from death in NLRP3-deficient (Nlrp3(-/-)) and NLRP3 inhibitor-treated wild-type (C57BL/6) mice...
December 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28028754/alteration-of-lysophosphatidylcholine-related-metabolic-parameters-in-the-plasma-of-mice-with-experimental-sepsis
#12
Won-Gyun Ahn, Jun-Sub Jung, Hyeok Yil Kwon, Dong-Keun Song
Plasma concentration of lysophosphatidylcholine (LPC) was reported to decrease in patients with sepsis. However, the mechanisms of sepsis-induced decrease in plasma LPC levels are not currently well known. In mice subjected to cecal ligation and puncture (CLP), a model of polymicrobial peritoneal sepsis, we examined alterations in LPC-related metabolic parameters in plasma, i.e., the plasma concentration of LPC-related substances (i.e., phosphatidylcholine (PC) and lysophosphatidic acid (LPA)), and activities or levels in the plasma of some enzymes that can be involved in the regulation of plasma LPC concentration (i...
December 28, 2016: Inflammation
https://www.readbyqxmd.com/read/28026831/the-role-of-ykl-40-in-a-cancerous-process
#13
Agnieszka Rusak, Karolina Jabłońska, Piotr Dzięgiel
YKL-40 is a secretory protein secreted among others by tumor cells and tumor-associated macrophages. Due to the structural homology this protein was classified to chitinases family CLP (chitinase - like protein) and to 18 of glycosyl hydrolase family, but it has no catalytic function. Elevated levels of YKL-40 in serum is observed in the inflammatory diseases of various aetiology and in cancers, such as breast, ovarian, colon or lung. The results of many studies suggest a significant relationship of YKL-40 with progression of cancer: incidence of metastases, shorter relapse-free survival and shorter overall survival...
December 27, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28024294/celecoxib-administration-reduced-mortality-mesenteric-hypoperfusion-aortic-dysfunction-and-multiple-organ-injury-in-septic-rats
#14
Erdem Kamil Ozer, Mustafa Tugrul Goktas, Ibrahim Kilinc, Hulagu Bariskaner, Ceyhan Ugurluoglu, Alper Bektas Iskit
BACKGROUND: The cyclooxygenase (COX)-2 overexpression is associated with vascular injury and multiple organ failure in sepsis. However, constitutive COX-1 and basal COX-2 expressions have physiological effects. We aimed to investigate the effects of partial and selective COX-2 inhibition without affecting constitutive COX-1 and basal COX-2 activities by celecoxib on mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries, and survival in septic rats accomplished by cecal ligation and puncture (CLP)...
December 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28013315/baicalin-inhibits-renal-cell-apoptosis-and-protects-against-acute-kidney-injury-in-pediatric-sepsis
#15
Yanping Zhu, Yanxia Fu, Hairong Lin
BACKGROUND Pediatric sepsis has high morbidity in children, may lead to acute kidney injury (AKI), and further aggravate the disease. Baicalin is a kind of flavonoid in Scutellaria baicalensis Georgi and has been reported to protect against several diseases, but its roles in septic AKI remain unclear. This study aimed to uncover the effects of baicalin in AKI during pediatric sepsis. MATERIAL AND METHODS Blood urea nitrogen (BUN) and serum creatinine (Cr) levels were detected in 50 pediatric patients, who underwent basic therapy with or without baicalin adjunctive therapy...
December 25, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28012331/multidisciplinary-management-of-a-patient-with-van-der-woude-syndrome-a-case-report
#16
Azita Tehranchi, Hossein Behnia, Nasser Nadjmi, Vahid Reza Yassaee, Zeinab Ravesh, Morteza Mina
INTRODUCTION: Van der Woude syndrome (VWS) is the most frequent form of syndromic cleft lip and palate (SCLP) accounting for 2% of all patients with CLP. CASE PRESENTATION: We describe the orthodontic treatment of a girl diagnosed with VWS referred by her family dentist for her cosmetic concerns. DISCUSSION: Comprehensive orthodontic treatment, secondary bone graft, distraction osteogenesis (for a deficient maxilla), secondary palatoplasty and excision of lower lip pits, as well as orthodontic and prosthetic procedures may provide a satisfactory outcome...
December 6, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28011675/cx3cr1-dependent-endothelial-margination-modulates-ly6chigh-monocyte-systemic-deployment-upon-inflammation-in-mice
#17
Pauline Hamon, Pierre-Louis Loyher, Camille Baudesson de Chanville, Fabrice Licata, Christophe Combadière, Alexandre Boissonnas
Two subsets of blood monocytes are commonly described in mice and humans; the classical inflammatory monocytes which are rapidly mobilized upon inflammation in a CC-chemokine receptor 2 (CCR2)-dependent manner, and the non-classical blood resident monocyte subset that patrol the intraluminal side of the endothelium. Old reports suggest that blood monocytes are distributed into circulating and marginating pools but no direct evidence of the latter has been obtained so far. Using a combination of in vivo real-time imaging and blood/tissue partitioning by intravascular staining of leukocytes, we showed that both inflammatory and resident monocytes are retained in the bone marrow vasculature, representing an important reservoir of marginated monocytes...
December 23, 2016: Blood
https://www.readbyqxmd.com/read/28007479/membrane-interactions-of-natural-cyclic-lipodepsipeptides-of-the-viscosin-group
#18
Niels Geudens, Mehmet Nail Nasir, Jean-Marc Crowet, Jos M Raaijmakers, Krisztina Fehér, Tom Coenye, José C Martins, Laurence Lins, Davy Sinnaeve, Magali Deleu
Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It has been established that interaction with the cellular membrane is central to the mode of action of CLPs. In this work, we focus on the CLPs of the so-called viscosin group, aiming to assess the impact of the main structural variations observed within this group on both the antimicrobial activity and the interaction with model membranes...
December 20, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28003866/sirt1-3-activation-by-resveratrol-attenuates-acute-kidney-injury-in-a-septic-rat-model
#19
Siqi Xu, Youguang Gao, Qin Zhang, Siwei Wei, Zhongqing Chen, Xingui Dai, Zhenhua Zeng, Ke-Seng Zhao
Sepsis often results in damage to multiple organ systems, possibly due to severe mitochondrial dysfunction. Two members of the sirtuin family, SIRT1 and SIRT3, have been implicated in the reversal of mitochondrial damage. The aim of this study was to determine the role of SIRT1/3 in acute kidney injury (AKI) following sepsis in a septic rat model. After drug pretreatment and cecal ligation and puncture (CLP) model reproduction in the rats, we performed survival time evaluation and kidney tissue extraction and renal tubular epithelial cell (RTEC) isolation...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28001381/treatment-of-sepsis-pathogenesis-with-high-mobility-group-box-protein-1-regulating-anti-inflammatory-agents
#20
Wansang Cho, Ja Young Koo, Yeonju Park, Keunhee Oh, Sanghee Lee, Jin-Sook Song, Myung Ae Bae, Donghyun Lim, Dong-Sup Lee, Seung Bum Park
Sepsis is one of the major causes of death worldwide when associated with multiple organ failure. However, there is a critical lack of adequate sepsis therapies because of its diverse patterns of pathogenesis. The pro-inflammatory cytokine cascade mediates sepsis pathogenesis, and high mobility group box proteins (HMGBs) play an important role as late-stage cytokines. We previously reported the small-molecule modulator, inflachromene (1d), which inhibits the release of HMGBs and, thereby, reduces the production of pro-inflammatory cytokines...
December 21, 2016: Journal of Medicinal Chemistry
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