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https://www.readbyqxmd.com/read/28551718/pelvic-artery-aneurysm-screening-provides-value-in-patients-with-thoracic-aortic-aneurysms
#1
Matthew Chapman, Leslie E Quint, Kuanwong Watcharotone, Bin Nan, Michael J Ranella, Mariana R DeFreitas, Joanna R Hider, Jonathan L Eliason, Himanshu J Patel
Approximately ¼ of patients with thoracic aortic aneurysms (TAAs) have concomitant abdominal aortic aneurysms (AAAs), thereby justifying the addition of an abdominal CT scan to a chest CT scan in patients with a newly diagnosed or suspected TAA. However, the prevalence of pelvic artery aneurysms (PAAs) in these patients is unknown. The purpose of this study was to determine the prevalence of PAAs in patients with TAAs and to assess what patient specific factors were associated with PAAs, thereby providing insight into the usefulness of pelvic imaging in TAA patients...
May 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28550589/carbon-dioxide-co2-angiography-as-an-option-for-endovascular-abdominal-aortic-aneurysm-repair-evar-in-patients-with-chronic-kidney-disease-ckd
#2
Chiara De Angelis, Francesco Sardanelli, Matteo Perego, Marco Alì, Francesco Casilli, Luigi Inglese, Giovanni Mauri
To assess feasibility, efficacy and safety of carbon dioxide (CO2) digital subtraction angiography (DSA) to guide endovascular aneurysm repair (EVAR) in a cohort of patients with chronic kidney disease (CKD). After Ethical Committee approval, the records of 13 patients (all male, mean age 74.6 ± 8.0 years) with CKD, who underwent EVAR to exclude an abdominal aortic aneurysm (AAA) under CO2 angiography guidance, were reviewed. The AAA to be excluded had a mean diameter of 52.0 ± 8.0 mm. CO2 angiography was performed by automatic (n = 7) or hand (n = 6) injection...
May 27, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28549957/three-stage-esophagectomy-combined-with-abdominal-aortic-aneurysm-repair-first-case-in-the-literature
#3
Chris Klonaris, Dimitrios Schizas, Georgios Karaolanis, Dimitrios Athanasiadis, Andreas Alexandrou, Theodore Liakakos
The purpose of this report is to describe the synchronous surgical treatment of an abdominal aortic aneurysm (AAA) with concomitant esophageal cancer (EC) with a three-stage esophagectomy, a real management challenge especially in establishing the therapeutic priorities and the ideal treatment approach. A 65-year old male was referred for treatment in our hospital with the diagnosis of AAA. He complained of general fatigue, weight loss and intermittent dysphagia. Contrast-enhanced CT and upper endoscopy showed the AAA and a large gastroesophageal junction (GEJ) tumor respectively...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549956/serum-high-sensitive-c-reactive-protein-hscrp-level-and-crp-genetic-polymorphisms-are-associated-with-abdominal-aortic-aneurysm
#4
Zuo Shangwei, Wei Yingqi, Xiong Jiang, Wu Zhongyin, Juan Juan, Chen Dafang, Hu Yonghua, Guo Wei
BACKGROUND: Abdominal aortic aneurysm (AAA) development involves an inflammatory process with a potential genetic background. C-reactive protein (CRP) is an acute phase protein and was elevated in patients with AAA. The aim of this study was to investigate the association among serum high-sensitive CRP (hsCRP) concentration, its CRP genetic polymorphisms and AAA. METHODS: Serum hsCRP concentrations and abdominal aorta diameters were measured, correlation analysis between them were performed in 155 unrelated participants with AAA and 310 non-AAA controls...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28548677/destabilization-of-human-insulin-fibrils-by-peptides-of-fruit-bromelain-derived-from-ananas-comosus-pineapple
#5
Sromona Das, Debasish Bhattacharyya
Deposition of insulin aggregates in human body leads to dysfunctioning of several organs. Effectiveness of fruit bromelain from pineapple in prevention of insulin aggregate was investigated. Proteolyses of bromelain was done as par human digestive system and the pool of small peptides was separated from larger peptides and proteins. Under conditions of growth of insulin aggregates from its monomers, this pool of peptides restricted the reaction upto formation of oligomers of limited size. These peptides also destabilized preformed insulin aggregates to oligomers...
May 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28548474/aortic-aneurysm-endovascular-treatment-with-the-parallel-graft-technique-from-the-aortic-arch-to-the-iliac-axis
#6
Gian F Fadda, Mario Marino, Holta Kasemi, Costantino L DI Angelo, Carlo P Dionisi, Valeria Cammalleri, Carlo Setacci
BACKGROUND: The chimney technique has been developed for the treatment of complex aortic aneurysms. We analyzed the midterm to long-term outcomes of this approach from a single- centre experience. METHODS: From October 2008 to July 2016, 58 patients underwent endovascular aortic aneurysm repair using the chimney technique. Indications for treatment were thoracic aortic aneurysm (TAA) (n = 11), thoracoabdominal aortic aneurysm (TAAA) (n = 2), pararenal aortic aneurysm (PAAA) (n= 15), aortoiliac/isolated hypogastric artery aneurysm (n = 25), type I endoleak after previous TEVAR/EVAR (n=4), proximal pseudoaneurysm after AAA open repair (n = 1)...
May 26, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28548204/endovascular-treatment-for-ruptured-abdominal-aortic-aneurysm
#7
REVIEW
Stephen Badger, Rachel Forster, Paul H Blair, Peter Ellis, Frank Kee, Denis W Harkin
BACKGROUND: An abdominal aortic aneurysm (AAA) (pathological enlargement of the aorta) is a condition that can occur as a person ages. It is most commonly seen in men older than 65 years of age. Progressive aneurysm enlargement can lead to rupture and massive internal bleeding, which is fatal unless timely repair can be achieved. Despite improvements in perioperative care, mortality remains high (approximately 50%) after conventional open surgical repair. Endovascular aneurysm repair (EVAR), a minimally invasive technique, has been shown to reduce early morbidity and mortality as compared to conventional open surgery for planned AAA repair...
May 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28546232/genetic-defects-in-pediatric-onset-adrenal-insufficiency-in-japan
#8
Naoko Amano, Satoshi Narumi, Mie Hayashi, Masaki Takagi, Kazuhide Imai, Toshirou Nakamura, Rumi Hachiya, Goro Sasaki, Keiko Homma, Tomohiro Ishii, Tomonobu Hasegawa
CONTEXT: Most patients with pediatric-onset primary adrenal insufficiency (PAI), such as 21-hydroxylase deficiency, can be diagnosed by measuring the urine or serum levels of steroid metabolites. However, the etiology is often difficult to determine in a subset of patients lacking characteristic biochemical findings. OBJECTIVE: To assess the frequency of genetic defects in Japanese children with biochemically uncharacterized PAI, and characterize the phenotypes of mutation-carrying patients...
May 25, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28546046/on-the-use-of-geometric-modeling-to-predict-aortic-aneurysm-rupture
#9
Sruthi L Muluk, Pallavi D Muluk, Judy Shum, Ender A Finol
BACKGROUND: Currently, the risk of abdominal aortic aneurysm (AAA) rupture is determined using the maximal diameter (Dmax) of the aorta. We sought in this study to identify a set of CT-based geometric parameters that would better predict the risk of rupture than Dmax. METHODS: We obtained CT Scans from 180 patients (90 ruptured AAA, 90 elective AAA repair) and then used automated software to calculate 1-dimensional, 2-dimensional, and 3-dimensional geometric parameters for each AAA...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28546041/10-years-single-centre-results-of-abdominal-aortic-aneurysm-treatment-endovascular-vs-open-repair
#10
Payman Majd, Wael Ahmad, Ingrid Becker, Jan Sigge Brunkwall
OBJECTIVES: The purpose of the present study was to compare the long-term survival in matched cohorts of patients with infrarenal abdominal aortic aneurysm (AAA) undergoing an elective open repair (OR) or an endovascular aneurysm repair (EVAR). MATERIALS AND METHODS: Patients with a primary elective repair of an infrarenal aortic aneurysm between 1998 and 2006 were identified in a retrospective review of our single centre database. EVAR and OR patients were matched with respect to age, gender, renal disease, tobacco use, hypertension, chronic obstructive pulmonary disease and coronary artery disease...
May 22, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28545777/inhibitory-effects-of-doxycycline-on-the-onset-and-progression-of-abdominal-aortic-aneurysm-and-its-related-mechanisms
#11
Maomao Yu, Cong Chen, Yini Cao, Rong Qi
The objective of this study was to investigate whether doxycycline (DOX) given at different doses and via different administration routes had protective or therapeutic effects on abdominal aortic aneurysm (AAA) induced by elastase in mice. Moreover, the anti-AAA mechanism of DOX was studied in TNF-α-stimulated vascular smooth muscle cell (VSMC) in vitro. For in vivo study, either daily administration of 30mg/kg of DOX by gavage or intraperitoneal injection of 15mg/kg DOX every other day for 14 days significantly prevented the development of AAA at its early stage...
May 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28545328/diabetes-mellitus-increases-the-risk-of-ruptured-abdominal-aortic-aneurysms
#12
Waldemar Wierzba, Andrzej Sliwczynski, Jaroslaw Pinkas, Arkadiusz Jawien, Waldemar Karnafel
The publication is a polemical response to reports that present data that diabetes reduces the risk of rupture of abdominal aortic aneurysm (AAA). The study analyzed all cases of developing AAA in patients with and without diabetes in 2012 in Poland. Data for the analysis were obtained with a unique and complete resources of the National Health Fund (NFZ) and population data from the Central Statistical Office (GUS). In Poland during 2012 2,227,453 patients with diabetes were treated, 975,364 males and 1,252,089 females...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28538996/the-relationship-between-surface-curvature-and-abdominal-aortic-aneurysm-wall-stress
#13
Sergio Ruiz de Galarreta, Aitor Cazon, Raúl Antón, Ender A Finol
The maximum diameter criterion is the most important factor when predicting risk of rupture of abdominal aortic aneurysms (AAA). An elevated wall stress has also been linked to a high risk of aneurysm rupture, yet is an uncommon clinical practice to compute AAA wall stress. The purpose of this study is to assess whether other characteristics of the AAA geometry are statistically correlated with wall stress. Using in-house segmentation and meshing algorithms, thirty patient-specific AAA models were generated for finite element analysis...
May 24, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28536693/the-essential-role-of-clpxp-in-caulobacter-crescentus-requires-species-constrained-substrate-specificity
#14
Robert H Vass, Jacob Nascembeni, Peter Chien
The ClpXP protease is a highly conserved AAA+ degradation machine that is present throughout bacteria and in eukaryotic organelles. ClpXP is essential in some bacteria, such as Caulobacter crescentus, but dispensible in others, such as Escherichia coli. In Caulobacter, ClpXP normally degrades the SocB toxin and increased levels of SocB result in cell death. ClpX can be deleted in cells lacking this toxin, but these ΔclpX strains are still profoundly deficient in morphology and growth supporting the existence of additional important functions for ClpXP...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28535921/out-of-field-in-vivo-dosimetry-using-tld-in-sabr-for-primary-kidney-cancer-involving-mixed-photon-fields
#15
P Lonski, S Keehan, S Siva, D Pham, R D Franich, M L Taylor, T Kron
PURPOSE: To assess out-of-field dose using three different variants of LiF thermoluminescence dosimeters (TLD) for ten patients who underwent stereotactic ablative body radiotherapy (SABR) for primary renal cell carcinoma (RCC) and compare with treatment planning system (TPS) dose calculations. METHODS AND MATERIALS: Thermoluminescent dosimeter (TLD) measurements were conducted at 20, 30, 40 and 50cm from isocentre on ten patients undergoing SABR for primary RCC...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28535909/dynamic-simulation-and-doppler-ultrasonography-validation-of-blood-flow-behavior-in-abdominal-aortic-aneurysm
#16
Cristian C Botar, Árpád Á Tóth, Olivera R Klisurić, Dijana D Nićiforović, Viktorija A Vučaj Ćirilović, Viktor E Till
Criteria for rupture prediction of Abdominal Aortic Aneurysm (AAA) are based only on the diameter of AAA. This method does not consider complex hemodynamic forces exerted on AAA wall. The methodology used in our study combines Computer-Aided Design (CAD) with Computational Fluid Dynamics (CFD). Three-dimensional vascular structures reconstructions were based on Computed Tomography (CT) images and CAD. CFD theory was used for mathematical modeling and simulations. In this way, dynamic behavior of blood flow in bounded three-dimensional space was described...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28534617/comparative-proteomics-reveals-timely-transport-into-cilia-of-regulators-or-effectors-as-a-mechanism-underlying-ciliary-disassembly
#17
Limei Wang, Lixiao Gu, Dan Meng, Qiong Wu, Haiteng Deng, Junmin Pan
Primary cilia are assembled and disassembled during cell cycle progression. During ciliary disassembly, ciliary axonemal microtubules (MTs) are depolymerized accompanied with extensive posttranslational protein modifications of ciliary proteins including protein phosphorylation, methylation and ubiquitination. These events are hypothesized to involve transport of effectors or regulators into cilia at the time of ciliary disassembly from the cell body. To prove this hypothesis and identify new proteins involved in ciliary disassembly, we analyzed disassembling flagella in Chlamydomonas using comparative proteomics with TMT labeling...
May 23, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28532922/awake-craniotomy-anesthesia-a-comparison-between-the-monitored-anesthesia-care-versus-the-asleep-awake-asleep-technique
#18
Chikezie I Eseonu, Karim ReFaey, Oscar Garcia, Amballur John, Alfredo Quinones-Hinojosa, Punita Tripathi
BACKGROUND: The commonly used sedation techniques for an awake craniotomy includes monitored anesthesia care(MAC), using an unprotected airway, or the asleep-awake-asleep(AAA) technique, using a partially or totally protected airway. We present a comparative analysis between the MAC and AAA technique evaluating anesthetic management, perioperative outcomes, and complications in a consecutive series of patients undergoing the removal of an eloquent brain lesion. METHODS: Eighty-one patients underwent an awake craniotomy for an intracranial lesion over a nine-year period by a single-surgeon and a team of anesthesiologists...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28527818/predictors-associated-with-increased-prevalence-of-abdominal-aortic-aneurysm-in-chinese-patients-with-atherosclerotic-risk-factors
#19
W Li, S Luo, J Luo, Y Liu, B Ning, W Huang, L Xue, J Chen
OBJECTIVE/BACKGROUND: Epidemiological screening studies have demonstrated that the prevalence of abdominal aortic aneurysm (AAA) of Asian origin appears to be low and so increases uncertainty about the cost effectiveness of screening for AAAs in Chinese people. Some studies have demonstrated a higher prevalence of AAA in patients with atherosclerotic risk factors. The purpose of the study was to determine the prevalence of AAA and to explore the high risk group of AAA in Chinese patients with atherosclerotic risk factors...
May 17, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28527730/experiences-of-the-screening-process-and-the-diagnosis-abdominal-aortic-aneurysm-among-65-year-old-men-from-invitation-to-a-1-year-surveillance
#20
Monica Pettersson, Anders Hansson, John Brodersen, Christine Kumlien
The prevalence of abdominal aortic aneurysm (AAA) is reported to be 2.2%-8% among men >65 years. During recent years, screening programs have been developed to detect AAA, prevent ruptures, and thereby saving lives. Therefore, most men with the diagnosis are monitored conservatively with regular reviews. The objective of the study was to describe how men diagnosed with abdominal aortic aneurysm <55 mm discovered by screening experience the process and diagnosis from invitation to 1 year after screening...
June 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
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