keyword
MENU ▼
Read by QxMD icon Read
search

Idiosyncratic

keyword
https://www.readbyqxmd.com/read/28109316/adenosine-induced-ventricular-fibrillation-in-a-structurally-normal-heart-a-case-report
#1
Christopher A Rajkumar, Norman Qureshi, Fu Siong Ng, Vasileios F Panoulas, Phang Boon Lim
BACKGROUND: Adenosine is the first-line pharmacotherapy for termination of supraventricular tachycardia through its action on the atrioventricular node. However, pro-arrhythmic effects of adenosine are also recognised, most notably in the presence of pre-excited atrial fibrillation. In this case report, we describe the induction of ventricular fibrillation in a patient with no demonstrable accessory pathway, nor any other structural heart disease. This rare, idiosyncratic reaction has never previously been reported and is of relevance given the widespread and routine use of adenosine in clinical practice...
January 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28104975/antiepileptic-drugs-induced-stevens-johnson-syndrome-a-case-series
#2
Bhavi S Trivedi, Nishita H Darji, Supriya D Malhotra, Pankaj R Patel
Stevens-Johnson syndrome (SJS) is an acute life-threatening mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of SJS is seen in five cases per million people per year. SJS is typically caused by drugs and is a kind of idiosyncratic reaction. Adverse drug reactions such an SJS have a remarkable effect on patient's safety issues. We encountered nine cases of antiepileptic drug (AED)-induced SJS, specifically with carbamazepine, oxcarbazepine, and phenytoin...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28104833/idiosyncratic-drug-induced-liver-injury-is-drug-cytokine-interaction-the-linchpin
#3
Robert A Roth, Ashley R Maiuri, Patricia E Ganey
Idiosyncratic drug-induced liver injury continues to be a human health problem in part because drugs that cause these reactions are not identified in current preclinical testing and because progress in prevention is hampered by incomplete knowledge of mechanisms that underlie these adverse responses. Several hypotheses involving adaptive immune responses, inflammatory stress, inability to adapt to stress, and multiple, concurrent factors have been proposed. Yet much remains unknown about how drugs interact with the liver to effect death of hepatocytes...
February 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28104590/germination-responses-to-current-and-future-temperatures-of-four-seeder-shrubs-across-a-latitudinal-gradient-in-western-iberia
#4
Daniel Chamorro, Belén Luna, José M Moreno
PREMISE OF THE STUDY: Species differ in their temperature germination niche. Populations of a species may similarly differ across the distribution range of the species. Anticipating the impacts of climate variability and change requires understanding the differential sensitivity to germination temperature among and within species. Here we studied the germination responses of four hard-seeded Cistaceae seeders to a range of current and future temperatures. METHODS: Seeds were collected at sites across the Iberian Peninsula and exposed or not exposed to a heat shock to break dormancy, then set to germinate under four temperature regimes...
January 19, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28101765/tolerability-and-safety-of-commonly-used-antiepileptic-drugs-in-adolescents-and-adults-a-clinician-s-overview
#5
REVIEW
Martin J Brodie
This paper discusses the issues surrounding the tolerability and safety of the commonly used antiepileptic drugs (AEDs) in adolescents and adults. The content includes dose-related adverse effects, idiosyncratic reactions, behavioural and psychiatric comorbidities, chronic problems, enzyme induction and teratogenesis. Twenty-one AEDs are discussed in chronological order of their introduction into the UK, starting with phenobarbital and ending with brivaracetam. Wherever possible, advice is given on anticipating, recognising and managing these issues and thereby improving the lives of people with epilepsy, most of whom will need to take one or more of these agents for life...
January 18, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28093677/communication-intervention-for-young-children-with-severe-neurodevelopmental-disabilities-via-telehealth
#6
Jessica Simacek, Adele F Dimian, Jennifer J McComas
Young children with neurodevelopmental disorders such as autism spectrum disorders (ASD) and Rett syndrome often experience severe communication impairments. This study examined the efficacy of parent-implemented communication assessment and intervention with remote coaching via telehealth on the acquisition of early communication skills of three young children with ASD (2) and Rett syndrome (1). Efficacy of the intervention was evaluated using single-case experimental designs. First, functional assessment was used to identify idiosyncratic/potentially communicative responses and contexts for each child...
January 16, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28089432/daily-living-pain-assessment-in-children-with-autism-exploratory-study
#7
A Dubois, C Michelon, C Rattaz, M Zabalia, A Baghdadli
This study aims to broaden knowledge about pain expression and assessment in daily life situations in children with Autism Spectrum Disorder (ASD). The goals are to provide a description of the responses of the GED-DI, the French version of the NCCPC, and to test the internal structure validity of this scale. Thirty five children with ASD were included in this study (mean age=58months; mean developmental age=32months). The French version of the NCCPC was filled in by parents. Descriptive analysis of responses shows that children with ASD express pain through varied and common behaviours, related to different expressive markers (vocal, facial, activity, etc...
January 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28080098/knowledge-of-the-self-control-benefits-of-high-level-versus-low-level-construal
#8
Karen E MacGregor, Jessica J Carnevale, Nicole E Dusthimer, Kentaro Fujita
Research indicates that inducing high-level construal (processing that highlights invariant, essential features) relative to low-level construal (processing that highlights idiosyncratic, peripheral features) promotes self-control (Fujita & Carnevale, 2012). In the present work, we investigate to what extent people recognize the self-control benefits of high-level construal, and explore the consequences of this knowledge. Studies 1 and 2 provide initial evidence that individuals are aware that high-level relative to low-level construal promotes self-control in the dieting domain...
January 12, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28077871/hyoliths-are-palaeozoic-lophophorates
#9
Joseph Moysiuk, Martin R Smith, Jean-Bernard Caron
Hyoliths are abundant and globally distributed 'shelly' fossils that appear early in the Cambrian period and can be found throughout the 280 million year span of Palaeozoic strata. The ecological and evolutionary importance of this group has remained unresolved, largely because of their poorly constrained soft anatomy and idiosyncratic scleritome, which comprises an operculum, a conical shell and, in some taxa, a pair of lateral spines (helens). Since their first description over 175 years ago, hyoliths have most often been regarded as incertae sedis, related to molluscs or assigned to their own phylum...
January 19, 2017: Nature
https://www.readbyqxmd.com/read/28077714/formation-of-long-term-locomotor-memories-is-associated-with-functional-connectivity-changes-in-the-cerebellar-thalamic-cortical-network
#10
Firas Mawase, Simona Bar-Haim, Lior Shmuelof
: Although motor adaptation is typically rapid, accumulating evidence shows that it is also associated with long-lasting behavioral and neuronal changes. Two processes were suggested to explain the formation of long-term motor memories: recall, reflecting a retrieval of previous motor actions, and faster relearning, reflecting an increased sensitivity to errors. Although these manifestations of motor memories were initially demonstrated in the context of adaptation experiments in reaching, indications of long-term motor memories were also demonstrated recently in other kinds of adaptation such as in locomotor adaptation...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28073177/idiosyncratic-drug-induced-liver-injury-associated-with-bile-duct-loss-and-vanishing-bile-duct-syndrome-rare-but-has-severe-consequences
#11
EDITORIAL
Einar S Björnsson, Jon Gunnlaugur Jonasson
No abstract text is available yet for this article.
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28072923/language-the-diabetes-restricted-code-dialect-and-what-it-means-for-people-with-diabetes-and-clinicians
#12
Trisha Dunning, Jane Speight, Craig Bennett
Purpose The purpose of the paper is to explore the notion of a diabetes language restricted code or "dialect" and its effect on people with diabetes. Language is a complex phenomenon comprising verbal and nonverbal components used to communicate in human interactions. Methods Information was collected from a literature review, during clinical consultations, and from an email survey. Results Language and the way clinicians use language affect motivation, behaviors, and outcomes of people with diabetes. Language is influenced by culture, experience, and familiarity with words and their use and is idiosyncratic...
January 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28069912/idiosyncratic-drug-induced-neutropenia-agranulocytosis
#13
Emmanuel Andrès, Rachel Mourot-Cottet, Frédéric Maloisel, François Séverac, Olivier Keller, Thomas Vogel, Martine Tebacher, Jean-Christophe Weber, Georges Kaltenbach, Jacques-Eric Gottenberg, Bernard Goichot, Jean Sibilia, Anne-Sophie Korganow, Raoul Herbrecht
BACKGROUD: Few data is currently available on neutropenia and agranulocytosis related to drug intake. We report here data on 203 patients with established idiosyncratic drug-induced agranulocytosis, followed up in a referral centre within a university hospital. PATIENTS AND METHODS: Data from 203 patients with idiosyncratic drug-induced agranulocytosis were retrospectively reviewed. All cases were extracted from a cohort study on agranulocytosis in the Strasbourg University Hospital (Strasbourg, France) RESULTS: : The mean age was 61...
January 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28069385/changes-of-renin-angiotensin-system-related-aminopeptidases-in-early-stage-alzheimer-s-disease
#14
Paul Richard Gard, Sara Fidalgo, Isabelle Lotter, Cassandra Richardson, Nicolas Farina, Jennifer Rusted, Naji Tabet
Activities of aminopeptidases A, B, and N (ApA, ApB & ApN) and insulin-regulated aminopeptidase (IRAP) have been seen to be decreased amongst patients with Alzheimer's disease (AD). All of these enzymes are involved with the brain renin-angiotensin system which is believed to be involved with learning and memory. This study aimed to explore the time course and the mechanisms underlying these changes. Serum samples were collected from 45 AD patients at the start of the study, and again 13months later (n=37)...
January 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28062205/effects-of-adjuvant-induced-inflammation-on-disposition-of-diclofenac-and-its-metabolites-in-perfused-rat-liver
#15
Misato Uraki, Atsushi Kawase, Hiroyuki Sayama, Yuka Matsushima, Masahiro Iwaki
The reactive metabolites of diclofenac (DF) such as 1-O-acyl glucuronide (DF-Glu) are hypothesized to result in idiosyncratic hepatotoxicity. However, it is unclear whether inflammation affects the hepatic disposition of DF and its metabolites. To clarify the alterations in the disposition of DF and its metabolites in inflammatory conditions, we performed in situ perfused rat liver experiments. Using adjuvant arthritis (AA) rats as a model of inflammation, the elimination of DF, 4'-hydroxydiclofenac (DF-4'OH), and DF-Glu from the perfusate was observed to be delayed in comparison with the control...
January 3, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28056801/polyploidy-and-the-relationship-between-leaf-structure-and-function-implications-for-correlated-evolution-of-anatomy-morphology-and-physiology-in-brassica
#16
Robert L Baker, Yulia Yarkhunova, Katherine Vidal, Brent E Ewers, Cynthia Weinig
BACKGROUND: Polyploidy is well studied from a genetic and genomic perspective, but the morphological, anatomical, and physiological consequences of polyploidy remain relatively uncharacterized. Whether these potential changes bear on functional integration or are idiosyncratic remains an open question. Repeated allotetraploid events and multiple genomic combinations as well as overlapping targets of artificial selection make the Brassica triangle an excellent system for exploring variation in the connection between plant structure (anatomy and morphology) and function (physiology)...
January 5, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28052385/fungi-exposed-to-chronic-nitrogen-enrichment-are-less-able-to-decay-leaf-litter
#17
Linda T A van Diepen, Serita D Frey, Elizabeth A Landis, Eric W Morrison, Anne Pringle
Saprotrophic fungi are the primary decomposers of plant litter in temperate forests, and their activity is critical for carbon (C) and nitrogen (N) cycling. Simulated atmospheric N deposition is associated with reduced fungal biomass, shifts in fungal community structure, slowed litter decay, and soil C accumulation. Although rarely studied, N deposition may also result in novel selective pressures on fungi, affecting evolutionary trajectories. To directly test if long-term N enrichment reshapes fungal responses to N, we isolated decomposer fungi from a long-term (28 yr) N-addition experiment and used a common garden approach to compare growth rates and decay abilities of isolates from control and N-amended plots...
January 2017: Ecology
https://www.readbyqxmd.com/read/28044020/auditory-multistability-and-neurotransmitter-concentrations-in-the-human-brain
#18
Hirohito M Kondo, Dávid Farkas, Susan L Denham, Tomohisa Asai, István Winkler
Multistability in perception is a powerful tool for investigating sensory-perceptual transformations, because it produces dissociations between sensory inputs and subjective experience. Spontaneous switching between different perceptual objects occurs during prolonged listening to a sound sequence of tone triplets or repeated words (termed auditory streaming and verbal transformations, respectively). We used these examples of auditory multistability to examine to what extent neurochemical and cognitive factors influence the observed idiosyncratic patterns of switching between perceptual objects...
February 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28035671/unique-associations-between-big-five-personality-aspects-and-multiple-dimensions-of-well-being
#19
Jessie Sun, Scott Barry Kaufman, Luke D Smillie
OBJECTIVE: Personality traits are associated with well-being, but the precise correlates vary across well-being dimensions and within each Big Five domain. This study is the first to examine the unique associations between the Big Five aspects (rather than facets) and multiple well-being dimensions. METHOD: Two samples of U.S. participants (Total N = 706, Mage = 36.17, 54% female) recruited via Amazon's Mechanical Turk completed measures of the Big Five aspects and subjective, psychological, and PERMA well-being...
December 30, 2016: Journal of Personality
https://www.readbyqxmd.com/read/28028199/idiosyncratic-patterns-of-representational-similarity-in-prefrontal-cortex-predict-attentional-performance
#20
Jeongmi Lee, Joy J Geng
: The efficiency of finding an object in a crowded environment depends largely on the similarity of non-targets to the search target. Models of attention theorize that the similarity is determined by representations stored within an "attentional template" held in working memory. However, the degree to which the contents of the attentional template are individually-unique and where those idiosyncratic representations are encoded in the brain, are unknown. We investigated this problem using representational similarity analysis (RSA) of human fMRI data to measure the common and idiosyncratic representations of famous face morphs during an identity categorization task; data from the categorization task were then used to predict performance on a separate identity search task...
December 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
keyword
keyword
98615
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"