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https://www.readbyqxmd.com/read/28535408/differences-in-clinical-and-cognitive-variables-in-seasonal-affective-disorder-compared-to-depressive-related-disorders-evidence-from-a-population-based-study-in-finland
#1
I Morales-Muñoz, S Koskinen, T Partonen
BACKGROUND: Seasonal affective disorder (SAD) is a type of depression with seasonal pattern. Although it involves some idiosyncratic symptoms, it can overlap with other depressive disorders such as major depressive disorder (MDD) or dysthymia. We aimed to characterize the differences in specific cognitive and clinical symptoms between SAD and depressive-related disorders. METHODS: In total, 4554 Finnish subjects from the population-based Health 2011 Survey were interviewed with the Munich version of Composite International Diagnostic Interview (M-CIDI) and filled in the Seasonal Pattern Assessment Questionnaire (SPAQ)...
March 28, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28535071/aphasia-from-the-inside-the-cognitive-world-of-the-aphasic-patient
#2
Alfredo Ardila, Silvia Rubio-Bruno
The purpose of this study was to analyze the question: how do people with aphasia experience the world? Three questions are approached: (1) how is behavior controlled in aphasia, considering that a normal linguistic control is no longer available; (2) what is the pattern of intellectual abilities in aphasia; and (3) what do aphasia patients' self-report regarding the experience of living without language. In aphasia, behavior can no longer be controlled through the "second signal system" and only the first signal system remains...
May 23, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28533580/olanzapine-induced-neuroleptic-malignant-syndrome
#3
Seyedhamze Hosseini, Forouzan Elyasi
Neuroleptic malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drugs. We present the case of a 27-year-old man with a history of paranoid schizophrenia that showed signs consistent with NMS that occurred after treatment with olanzapine...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28532257/suicide-and-sensibility
#4
Colin Tatz
Suicide is a domain of darkness. Entrenched in the biomedical world, suicide is commonly addressed as a complication of mental illness-usually depression-regardless of historic and social contexts, factors critical in Australian Aboriginal suicide. Prevention programs disappoint, partly because they don't differentiate between suicide categories in their strategies. Furthermore, statistics are unreliable, and under-reporting remains idiosyncratic despite improved coronial practices. Unhelpfully, coroners may not presume suicide...
May 22, 2017: Death Studies
https://www.readbyqxmd.com/read/28525267/the-supernatant-from-hepatocyte-cultures-with-drugs-that-cause-idiosyncratic-liver-injury-activates-macrophage-inflammasomes
#5
Ryuji Kato, Jack Uetrecht
There is increasing evidence that most idiosyncratic drug-induced liver injury (IDILI) is immune mediated, and in most cases reactive metabolites appear to be responsible for induction of this immune response. Reactive metabolites can cause cell damage with the release of damage-associated molecular patterns (DAMPs), which is thought to be involved in immune activation. Presumably the reason that the liver is a common target of idiosyncratic drug reactions is because it is the major site of drug metabolism and reactive metabolite formation...
May 19, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28523600/sodium-channel-blockers-in-the-treatment-of-epilepsy
#6
Martin J Brodie
Sodium channel blockers have been the mainstay of the pharmacological management of focal and generalised tonic-clonic seizures for more than 70 years. The focus of this paper will be on phenytoin, carbamazepine, lamotrigine, oxcarbazepine, rufinamide, lacosamide and eslicarbazepine acetate. All these antiepileptic drugs have similar efficacy and share similar dose-dependent, adverse effect profiles, although phenytoin, carbamazepine and oxcarbazepine are more likely to cause idiosyncratic reactions than the others...
May 18, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28523534/idiosyncratic-drug-induced-liver-injury-linked-to-polygonum-multiflorum-a-case-study-by-pharmacognosy
#7
Chun-Yu Li, Qin He, Dan Gao, Rui-Yu Li, Yun Zhu, Hui-Fang Li, Wu-Wen Feng, Mei-Hua Yang, Xiao-He Xiao, Jia-Bo Wang
No abstract text is available yet for this article.
May 18, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28502879/genetic-deletion-of-p-glycoprotein-alters-stress-responsivity-and-increases-depression-like-behavior-social-withdrawal-and-microglial-activation-in-the-hippocampus-of-female-mice
#8
Natalia I Brzozowska, Kristie L Smith, Cilla Zhou, Peter M Waters, Ligia Menezes Cavalcante, Sarah V Abelev, Michael Kuligowski, David J Clarke, Stephanie M Todd, Jonathon C Arnold
P-glycoprotein (P-gp) is an ABC transporter expressed at the blood brain barrier and regulates the brain uptake of various xenobiotics and endogenous mediators including glucocorticoid hormones which are critically important to the stress response. Moreover, P-gp is expressed on microglia, the brain's immune cells, which are activated by stressors and have an emerging role in psychiatric disorders. We therefore hypothesised that germline P-gp deletion in mice might alter the behavioral and microglial response to stressors...
May 10, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28495327/vocal-change-patterns-during-a-teaching-day-inter-and-intra-subject-variability
#9
Angélique Remacle, Maëva Garnier, Silvain Gerber, Claire David, Caroline Petillon
OBJECTIVES: The study aimed to describe the average response of 22 female teachers to vocal fatigue during a workday, to examine their inter- and intra-subject variability, and to establish a typology of different responses to vocal fatigue. METHODS: Fundamental frequency (F0), harmonics-to-noise ratio (HNR), jitter, and shimmer were measured for each participant on sustained vowels at the beginning and at the end of the workday, on three different times of the school year...
May 8, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28486401/drug-induced-liver-injury-cascade-of-events-leading-to-cell-death-apoptosis-or-necrosis
#10
REVIEW
Andrea Iorga, Lily Dara, Neil Kaplowitz
Drug-induced liver injury (DILI) can broadly be divided into predictable and dose dependent such as acetaminophen (APAP) and unpredictable or idiosyncratic DILI (IDILI). Liver injury from drug hepatotoxicity (whether idiosyncratic or predictable) results in hepatocyte cell death and inflammation. The cascade of events leading to DILI and the cell death subroutine (apoptosis or necrosis) of the cell depend largely on the culprit drug. Direct toxins to hepatocytes likely induce oxidative organelle stress (such as endoplasmic reticulum (ER) and mitochondrial stress) leading to necrosis or apoptosis, while cell death in idiosyncratic DILI (IDILI) is usually the result of engagement of the innate and adaptive immune system (likely apoptotic), involving death receptors (DR)...
May 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28485700/disgust-and-anger-relate-to-different-aggressive-responses-to-moral-violations
#11
Catherine Molho, Joshua M Tybur, Ezgi Güler, Daniel Balliet, Wilhelm Hofmann
In response to the same moral violation, some people report experiencing anger, and others report feeling disgust. Do differences in emotional responses to moral violations reflect idiosyncratic differences in the communication of outrage, or do they reflect differences in motivational states? Whereas equivalence accounts suggest that anger and disgust are interchangeable expressions of condemnation, sociofunctional accounts suggest that they have distinct antecedents and consequences. We tested these accounts by investigating whether anger and disgust vary depending on the costs imposed by moral violations and whether they differentially correspond with aggressive tendencies...
May 2017: Psychological Science
https://www.readbyqxmd.com/read/28483865/behavioural-ecological-and-evolutionary-responses-to-extreme-climatic-events-challenges-and-directions
#12
Martijn van de Pol, Stéphanie Jenouvrier, Johannes H C Cornelissen, Marcel E Visser
More extreme climatic events (ECEs) are among the most prominent consequences of climate change. Despite a long-standing recognition of the importance of ECEs by paleo-ecologists and macro-evolutionary biologists, ECEs have only recently received a strong interest in the wider ecological and evolutionary community. However, as with many rapidly expanding fields, it lacks structure and cohesiveness, which strongly limits scientific progress. Furthermore, due to the descriptive and anecdotal nature of many ECE studies it is still unclear what the most relevant questions and long-term consequences are of ECEs...
June 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28480008/designing-better-frog-call-recognition-models
#13
Paul S Crump, Jeff Houlahan
Advances in bioacoustic technology, such as the use of automatic recording devices, allow wildlife monitoring at large spatial scales. However, such technology can produce enormous amounts of audio data that must be processed and analyzed. One potential solution to this problem is the use of automated sound recognition tools, but we lack a general framework for developing and validating these tools. Recognizers are computer models of an animal sound assembled from "training data" (i.e., actual samples of vocalizations)...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28479991/intra-trophic-isotopic-discrimination-of-15-n-14-n-for-amino-acids-in-autotrophs-implications-for-nitrogen-dynamics-in-ecological-studies
#14
Yuko Takizawa, Prarthana S Dharampal, Shawn A Steffan, Yoshinori Takano, Naohiko Ohkouchi, Yoshito Chikaraishi
The differential discrimination of nitrogen isotopes ((15)N/(14)N) within amino acids in consumers and their diets has been routinely used to estimate organismal tropic position (TP). Analogous isotopic discrimination can occur within plants, particularly in organs lacking chloroplasts. Such discrimination likely arises from the catabolic deamination of amino acids, resulting in a numerical elevation of estimated TP, within newly synthesized biomass. To investigate this phenomenon, we examined the (15)N/(14)N of amino acids (δ(15) NAA) in spring leaves and flowers from eight deciduous and two annual plants...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28470132/value-based-hr-practices-i-deals-and-clinical-error-control-with-csr-as-a-moderator
#15
Tuan Luu, Chris Rowley, Sununta Siengthai, Vo Thanh Thao
Purpose Notwithstanding the rising magnitude of system factors in patient safety improvement, "human factors" such as idiosyncratic deals (i-deals) which also contribute to the adjustment of system deficiencies should not be neglected. The purpose of this paper is to investigate the role of value-based HR practices in catalyzing i-deals, which then influence clinical error control. The research further examines the moderating role of corporate social responsibility (CSR) on the effect of value-based HR practices on i-deals...
May 8, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28463921/the-cost-effectiveness-of-dual-mobility-implants-for-primary-total-hip-arthroplasty-a-computer-based-cost-utility-model
#16
Brian T Barlow, Alexander S McLawhorn, Geoffrey H Westrich
BACKGROUND: Dislocation remains a clinically important problem following primary total hip arthroplasty, and it is a common reason for revision total hip arthroplasty. Dual mobility (DM) implants decrease the risk of dislocation but can be more expensive than conventional implants and have idiosyncratic failure mechanisms. The purpose of this study was to investigate the cost-effectiveness of DM implants compared with conventional bearings for primary total hip arthroplasty. METHODS: Markov model analysis was conducted from the societal perspective with use of direct and indirect costs...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28462985/the-state-and-the-development-of-an-information-society-greek-policy-and-experience
#17
Dimitris Boucas
The paper looks into the dynamics of information society policy and its implementation in the Greek context. It argues that information society development is a contested process, influenced by pre-existing state, economy and society relations. Based on this, it looks into the different aspects of the idiosyncratic path which the evolution of the Greek information society has followed, particularly after 2000. Using Bob Jessop's strategic-relational approach (SRA) to the state as an analytical framework and drawing on a number of in-depth interviews with relevant political actors, it provides insights into policy implementation by examining: the public management of information technology projects, how such projects were received in bureaucratic structures and practices, as well as the relationship between the state and the information and communication technology (ICT) sector in public procurement processes...
April 30, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28453549/idiosyncratic-recognition-of-uug-uua-codons-by-modified-nucleoside-5-taurinomethyluridine-%C3%AF-m5u-present-at-wobble-position-in-anticodon-loop-of-trnaleu-a-molecular-modeling-approach
#18
Asmita S Kamble, Prayagraj M Fandilolu, Susmit B Sambhare, Kailas D Sonawane
Lack of naturally occurring modified nucleoside 5-taurinomethyluridine (τm5U) at the 'wobble' 34th position in tRNALeu causes mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The τm5U34 specifically recognizes UUG and UUA codons. Structural consequences of τm5U34 to read cognate codons have not been studied so far in detail at the atomic level. Hence, 50ns multiple molecular dynamics (MD) simulations of various anticodon stem loop (ASL) models of tRNALeu in presence and absence of τm5U34 along with UUG and UUA codons were performed to explore the dynamic behaviour of τm5U34 during codon recognition process...
2017: PloS One
https://www.readbyqxmd.com/read/28452230/comparing-book-and-tablet-based-picture-activity-schedules-acquisition-and-preference
#19
Aimee Giles, Victoria Markham
Picture activity schedules consist of a sequence of images representing the order of tasks for a person to complete. Although, picture activity schedules have traditionally been presented in a book format, recently picture activity schedules have been evaluated on technological devices such as an iPod™ touch. The present study compared the efficiency of picture activity schedule acquisition on book- and tablet-based modalities. In addition, participant preference for each modality was assessed. Three boys aged below 5 years with a diagnosis of autism participated...
April 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28450753/new-evidence-on-self-affirmation-effects-and-theorized-sources-of-heterogeneity-from-large-scale-replications
#20
Paul Hanselman, Christopher S Rozek, Jeffrey Grigg, Geoffrey D Borman
Brief, targeted self-affirmation writing exercises have recently been offered as a way to reduce racial achievement gaps, but evidence about their effects in educational settings is mixed, leaving ambiguity about the likely benefits of these strategies if implemented broadly. A key limitation in interpreting these mixed results is that they come from studies conducted by different research teams with different procedures in different settings; it is therefore impossible to isolate whether different effects are the result of theorized heterogeneity, unidentified moderators, or idiosyncratic features of the different studies...
April 2017: Journal of Educational Psychology
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