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https://www.readbyqxmd.com/read/28426802/decoding-the-infant-mind-multivariate-pattern-analysis-mvpa-using-fnirs
#1
Lauren L Emberson, Benjamin D Zinszer, Rajeev D S Raizada, Richard N Aslin
The MRI environment restricts the types of populations and tasks that can be studied by cognitive neuroscientists (e.g., young infants, face-to-face communication). FNIRS is a neuroimaging modality that records the same physiological signal as fMRI but without the constraints of MRI, and with better spatial localization than EEG. However, research in the fNIRS community largely lacks the analytic sophistication of analogous fMRI work, restricting the application of this imaging technology. The current paper presents a method of multivariate pattern analysis for fNIRS that allows the authors to decode the infant mind (a key fNIRS population)...
2017: PloS One
https://www.readbyqxmd.com/read/28419261/challenges-in-adapting-existing-clinical-natural-language-processing-systems-to-multiple-diverse-health-care-settings
#2
David S Carrell, Robert E Schoen, Daniel A Leffler, Michele Morris, Sherri Rose, Andrew Baer, Seth D Crockett, Rebecca A Gourevitch, Katie M Dean, Ateev Mehrotra
Objective: Widespread application of clinical natural language processing (NLP) systems requires taking existing NLP systems and adapting them to diverse and heterogeneous settings. We describe the challenges faced and lessons learned in adapting an existing NLP system for measuring colonoscopy quality. Materials and Methods: Colonoscopy and pathology reports from 4 settings during 2013-2015, varying by geographic location, practice type, compensation structure, and electronic health record...
April 17, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28418023/human-induced-pluripotent-stem-cells-for-modelling-neurodevelopmental-disorders
#3
REVIEW
Karthikeyan Ardhanareeswaran, Jessica Mariani, Gianfilippo Coppola, Alexej Abyzov, Flora M Vaccarino
We currently have a poor understanding of the pathogenesis of neurodevelopmental disorders, owing to the fact that postmortem and imaging studies can only measure the postnatal status quo and offer little insight into the processes that give rise to the observed outcomes. Human induced pluripotent stem cells (hiPSCs) should, in principle, prove powerful for elucidating the pathways that give rise to neurodevelopmental disorders. hiPSCs are embryonic-stem-cell-like cells that can be derived from somatic cells...
April 18, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28413254/non-farm-entrepreneurship-in-rural-sub-saharan-africa-new-empirical-evidence
#4
Paula Nagler, Wim Naudé
We report on the prevalence and patterns of non-farm enterprises in six sub-Saharan African countries, and study their performance in terms of labor productivity, survival and exit, using the World Bank's Living Standards Measurement Study - Integrated Surveys on Agriculture (LSMS-ISA). Rural households operate enterprises due to both push and pull factors and tend to do so predominantly in easy-to-enter activities, such as sales and trade, rather than in activities that require higher starting costs, such as transport services, or educational investment, such as professional services...
February 2017: Food Policy
https://www.readbyqxmd.com/read/28411929/updates-in-decompression-illness
#5
REVIEW
Neal W Pollock, Dominique Buteau
Decompression sickness and arterial gas embolism, collectively known as decompression illness (DCI), are rare but serious afflictions that can result from compressed gas diving exposures. Risk is primarily determined by the pressure-time profile but is influenced by several factors. DCI can present idiosyncratically but with a wide range of neurologic symptoms. Examination is critical for assessment in the absence of diagnostic indicators. Many conditions must be considered in the differential diagnosis. High-fraction oxygen breathing provides first aid but definitive treatment of DCI is hyperbaric oxygen...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28408011/determining-criteria-and-weights-for-prioritizing-health-technologies-based-on-the-preferences-of-the-general-population-a-new-zealand-pilot-study
#6
Trudy Sullivan, Paul Hansen
OBJECTIVES: The use of multicriteria decision analysis for health technology prioritization depends on decision-making criteria and weights according to their relative importance. We report on a methodology for determining criteria and weights that was developed and piloted in New Zealand and enables extensive participation by members of the general population. METHODS: Stimulated by a preliminary ranking exercise that involved prioritizing 14 diverse technologies, six focus groups discussed what matters to people when thinking about technologies that should be funded...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28405790/csh-guidelines-for-the-diagnosis-and-treatment-of-drug-induced-liver-injury
#7
EDITORIAL
Yue-Cheng Yu, Yi-Min Mao, Cheng-Wei Chen, Jin-Jun Chen, Jun Chen, Wen-Ming Cong, Yang Ding, Zhong-Ping Duan, Qing-Chun Fu, Xiao-Yan Guo, Peng Hu, Xi-Qi Hu, Ji-Dong Jia, Rong-Tao Lai, Dong-Liang Li, Ying-Xia Liu, Lun-Gen Lu, Shi-Wu Ma, Xiong Ma, Yue-Min Nan, Hong Ren, Tao Shen, Hao Wang, Ji-Yao Wang, Tai-Ling Wang, Xiao-Jin Wang, Lai Wei, Qing Xie, Wen Xie, Chang-Qing Yang, Dong-Liang Yang, Yan-Yan Yu, Min-de Zeng, Li Zhang, Xin-Yan Zhao, Hui Zhuang
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury based on the types of injured target cells...
April 12, 2017: Hepatology International
https://www.readbyqxmd.com/read/28402586/shifts-in-community-size-structure-drive-temperature-invariance-of-secondary-production-in-a-stream-warming-experiment
#8
Daniel Nelson, Jonathan P Benstead, Alexander D Huryn, Wyatt F Cross, James M Hood, Philip W Johnson, James R Junker, Gísli M Gíslason, Jón S Ólafsson
A central question at the interface of food-web and climate change research is how secondary production, or the formation of heterotroph biomass over time, will respond to rising temperatures. The metabolic theory of ecology (MTE) hypothesizes the temperature-invariance of secondary production, driven by matched and opposed forces that reduce biomass of heterotrophs while increasing their biomass turnover rate (production:biomass, or P:B) with warming. To test this prediction at the whole community level, we used a geothermal heat exchanger to experimentally warm a stream in southwest Iceland by 3...
April 12, 2017: Ecology
https://www.readbyqxmd.com/read/28398290/a-geographically-diverse-collection-of-418-human-gut-microbiome-pathway-genome-databases
#9
Aria S Hahn, Tomer Altman, Kishori M Konwar, Niels W Hanson, Dongjae Kim, David A Relman, David L Dill, Steven J Hallam
Advances in high-throughput sequencing are reshaping how we perceive microbial communities inhabiting the human body, with implications for therapeutic interventions. Several large-scale datasets derived from hundreds of human microbiome samples sourced from multiple studies are now publicly available. However, idiosyncratic data processing methods between studies introduce systematic differences that confound comparative analyses. To overcome these challenges, we developed GutCyc, a compendium of environmental pathway genome databases (ePGDBs) constructed from 418 assembled human microbiome datasets using MetaPathways, enabling reproducible functional metagenomic annotation...
April 11, 2017: Scientific Data
https://www.readbyqxmd.com/read/28398242/drug-induced-liver-injury-can-biomarkers-assist-rucam-in-causality-assessment
#10
REVIEW
Rolf Teschke, Johannes Schulze, Axel Eickhoff, Gaby Danan
Drug induced liver injury (DILI) is a potentially serious adverse reaction in a few susceptible individuals under therapy by various drugs. Health care professionals facing DILI are confronted with a wealth of drug-unrelated liver diseases with high incidence and prevalence rates, which can confound the DILI diagnosis. Searching for alternative causes is a key element of RUCAM (Roussel Uclaf Causality Assessment Method) to assess rigorously causality in suspected DILI cases. Diagnostic biomarkers as blood tests would be a great help to clinicians, regulators, and pharmaceutical industry would be more comfortable if, in addition to RUCAM, causality of DILI can be confirmed...
April 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28396415/variations-in-crowding-saccadic-precision-and-spatial-localization-reveal-the-shared-topology-of-spatial-vision
#11
John A Greenwood, Martin Szinte, Bilge Sayim, Patrick Cavanagh
Visual sensitivity varies across the visual field in several characteristic ways. For example, sensitivity declines sharply in peripheral (vs. foveal) vision and is typically worse in the upper (vs. lower) visual field. These variations can affect processes ranging from acuity and crowding (the deleterious effect of clutter on object recognition) to the precision of saccadic eye movements. Here we examine whether these variations can be attributed to a common source within the visual system. We first compared the size of crowding zones with the precision of saccades using an oriented clock target and two adjacent flanker elements...
April 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28392932/delay-discounting-and-utility-for-money-or-weight-loss
#12
Y Y Sze, E M Slaven, W K Bickel, L H Epstein
OBJECTIVE: Obesity is related to a bias towards smaller immediate over larger delayed rewards. This bias is typically examined by studying single commodity discounting. However, weight loss often involves choices among multiple commodities. To our knowledge, no research has examined delay discounting of delayed weight loss compared with other commodities. METHODS: We examined single commodity discounting of money and cross commodity discounting of money and weight loss in a sample of 84 adults with obesity or overweight statuses interested in weight loss...
March 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28387107/-bilateral-angle-closure-glaucoma-induced-by-topiramate
#13
O Beaudry, V Goncette, N Collignon
Topiramate (TPM) is a drug used in migraine prophylaxis. It is involved in the bilateral angle-closure glaucoma due to idiosyncratic response. This side effect is rare but can lead to irreversible vision loss if it is not recognized in time and if it is not managed immediately by an ophthalmologist.
November 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28384481/cognitive-states-influence-dopamine-driven-aberrant-learning-in-parkinson-s-disease
#14
James F Cavanagh, Andrea A Mueller, Darin R Brown, Jacqueline R Janowich, Jacqueline H Story-Remer, Ashley Wegele, Sarah Pirio Richardson
Individual differences in dopaminergic tone underlie tendencies to learn from reward versus punishment. These effects are well documented in Parkinson's patients, who vacillate between low and high tonic dopaminergic states as a function of medication. Yet very few studies have investigated the influence of higher-level cognitive states known to affect downstream dopaminergic learning in Parkinson's patients. A dopamine-dependent cognitive influence over learning would provide a candidate mechanism for declining cognitive integrity and motivation in Parkinson's patients...
March 20, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28383671/drug-induced-liver-injury-in-oncology
#15
A D Ricart
Liver regeneration has been an adaptation of vertebrates through evolutionary events to protect them from environmental pressures (e.g. ingested toxins). Elevated serum levels of aminotransferases generally indicate liver injury, but do not necessarily reflect or predict hepatotoxicity. Drug-induced liver injury (DILI) is first classified as predictable or unpredictable (idiosyncratic). Predictable DILI is dose-related and occurs shortly after exposure (e.g. high dose alkylating agents). Unpredictable reactions result from a succession of unlikely events, a "multihit" process (e...
April 5, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28379596/liver-transplantation-for-drug-induced-acute-liver-failure
#16
M Biolato, C Araneo, G Marrone, A Liguori, L Miele, F R Ponziani, A Gasbarrini, A Grieco
OBJECTIVES: To summarize the different clinical features of drug-induced acute liver failure, the diagnostic work-up, conservative management and the prognostic scores currently used to list patients for liver transplantation. EVIDENCE AND INFORMATION SOURCES: The current review is based on an analysis of the current literature and the caseload experience of the Authors on this topic. STATE OF THE ART: Drug-induced liver injury is the leading cause of acute liver failure in the adult population in Western countries, with a transplant-free survival rate of less than 50%...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28379595/hepatotoxicity-induced-by-greater-celandine-chelidonium-majus-l-a-review-of-the-literature
#17
F Pantano, G Mannocchi, E Marinelli, S Gentili, S Graziano, F P Busardò, N M di Luca
The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper. Identification of significant scientific literature was performed via the following research databases: Cochrane Central, Google Scholar, EMBASE, Medline, Science Direct, Scopus, Web of Science, using the following keywords: "Chelidonium majus", "greater celandine", "Hepatotoxicity", "Liver" "Injury", "Toxicity" individually investigated and then again in association...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28379587/drug-induced-liver-injury-2017-the-diagnosis-is-not-easy-but-always-to-keep-in-mind
#18
G Marrone, F G Vaccaro, M Biolato, L Miele, A Liguori, C Araneo, F R Ponziani, N Mores, A Gasbarrini, A Grieco
A drug-induced liver injury (DILI) is defined as a liver injury caused by exposure to a drug or a non-infectious toxic agent with a variable degree of organ dysfunction. A better understanding of DILI epidemiology has been obtained in recent years with the institution of international registries in the United States and Europe. Despite the advances in the understanding and characterization of the phenomenon, DILI remains an exclusion diagnosis so, probability scores and the analysis of literature reports are useful tools in dealing with a suspected DILI...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28377755/production-of-superoxide-in-bacteria-is-stress-and-cell-state-dependent-a-gating-optimized-flow-cytometry-method-that-minimizes-ros-measurement-artifacts-with-fluorescent-dyes
#19
Megan E McBee, Yok H Chionh, Mariam L Sharaf, Peiying Ho, Maggie W L Cai, Peter C Dedon
The role of reactive oxygen species (ROS) in microbial metabolism and stress response has emerged as a major theme in microbiology and infectious disease. Reactive fluorescent dyes have the potential to advance the study of ROS in the complex intracellular environment, especially for high-content and high-throughput analyses. However, current dye-based approaches to measuring intracellular ROS have the potential for significant artifacts. Here, we describe a robust platform for flow cytometric quantification of ROS in bacteria using fluorescent dyes, with ROS measurements in 10s-of-1000s of individual cells under a variety of conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28377161/category-selectivity-in-human-visual-cortex-beyond-visual-object-recognition
#20
Marius V Peelen, Paul E Downing
Human ventral temporal cortex shows a categorical organization, with regions responding selectively to faces, bodies, tools, scenes, words, and other categories. Why is this? Traditional accounts explain category selectivity as arising within a hierarchical system dedicated to visual object recognition. For example, it has been proposed that category selectivity reflects the clustering of category-associated visual feature representations, or that it reflects category-specific computational algorithms needed to achieve view invariance...
April 1, 2017: Neuropsychologia
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