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https://www.readbyqxmd.com/read/29156639/constructing-an-indoor-floor-plan-using-crowdsourcing-based-on-magnetic-fingerprinting
#1
Haiyong Luo, Fang Zhao, Mengling Jiang, Hao Ma, Yuexia Zhang
A large number of indoor positioning systems have recently been developed to cater for various location-based services. Indoor maps are a prerequisite of such indoor positioning systems; however, indoor maps are currently non-existent for most indoor environments. Construction of an indoor map by external experts excludes quick deployment and prevents widespread utilization of indoor localization systems. Here, we propose an algorithm for the automatic construction of an indoor floor plan, together with a magnetic fingerprint map of unmapped buildings using crowdsourced smartphone data...
November 20, 2017: Sensors
https://www.readbyqxmd.com/read/29156581/an-enhanced-non-coherent-pre-filter-design-for-tracking-error-estimation-in-gnss-receivers
#2
Zhibin Luo, Jicheng Ding, Lin Zhao, Mouyan Wu
Tracking error estimation is of great importance in global navigation satellite system (GNSS) receivers. Any inaccurate estimation for tracking error will decrease the signal tracking ability of signal tracking loops and the accuracies of position fixing, velocity determination, and timing. Tracking error estimation can be done by traditional discriminator, or Kalman filter-based pre-filter. The pre-filter can be divided into two categories: coherent and non-coherent. This paper focuses on the performance improvements of non-coherent pre-filter...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156560/system-modeling-of-a-mems-vibratory-gyroscope-and-integration-to-circuit-simulation
#3
Hyukjin J Kwon, Seyeong Seok, Geunbae Lim
Recently, consumer applications have dramatically created the demand for low-cost and compact gyroscopes. Therefore, on the basis of microelectromechanical systems (MEMS) technology, many gyroscopes have been developed and successfully commercialized. A MEMS gyroscope consists of a MEMS device and an electrical circuit for self-oscillation and angular-rate detection. Since the MEMS device and circuit are interactively related, the entire system should be analyzed together to design or test the gyroscope. In this study, a MEMS vibratory gyroscope is analyzed based on the system dynamic modeling; thus, it can be mathematically expressed and integrated into a circuit simulator...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29156382/discovery-of-selective-dengue-virus-inhibitors-using-combination-of-molecular-fingerprint-based-virtual-screening-protocols-structure-based-pharmacophore-model-development-molecular-dynamics-simulations-and-in-vitro-studies
#4
Shaher Bano Mirza, Regina Ching Hua Lee, Justin Jang Hann Chu, Ramin Ekhteiari Salmas, Thomas Mavromoustakos, Serdar Durdagi
Dengue virus is a major issue of tropical and sub-tropical regions. The proliferation of virus results in immense number of deaths each year because of unavailability of on-shelf drugs. This issue necessitates the design of novel anti-Dengue drugs. The protease enzyme pathway is the critical target for drug design due to its significance in the replication, survival and other cellular activities of Dengue virus. Keeping in mind the worsening situation regarding Dengue virus, approximately eighteen million drug-like compounds from the ZINC small molecule database have been screened against Nonstructural Protein 3 (NS3) previously by our group...
October 24, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29156088/climate-mediated-changes-in-marine-ecosystem-regulation-during-el-ni%C3%A3-o
#5
Martin Lindegren, David M Checkley, J Anthony Koslow, Ralf Goericke, Mark D Ohman
The degree to which ecosystems are regulated through bottom-up, top-down or direct physical processes represents a long-standing issue in ecology, with important consequences for resource management and conservation. In marine ecosystems, the role of bottom-up and top-down forcing has been shown to vary over spatio-temporal scales, often linked to highly variable and heterogeneously distributed environmental conditions. Ecosystem dynamics in the Northeast Pacific have been suggested to be predominately bottom-up regulated...
November 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29155894/estimating-virus-effective-population-size-and-selection-without-neutral-markers
#6
Elsa Rousseau, Benoît Moury, Ludovic Mailleret, Rachid Senoussi, Alain Palloix, Vincent Simon, Sophie Valière, Frédéric Grognard, Frédéric Fabre
By combining high-throughput sequencing (HTS) with experimental evolution, we can observe the within-host dynamics of pathogen variants of biomedical or ecological interest. We studied the evolutionary dynamics of five variants of Potato virus Y (PVY) in 15 doubled-haploid lines of pepper. All plants were inoculated with the same mixture of virus variants and, variant frequencies were determined by HTS in eight plants of each pepper line, at each of six sampling dates. We developed a method for estimating the intensities of selection and genetic drift in a multi-allelic Wright-Fisher model, applicable whether these forces are strong or weak, and in the absence of neutral markers...
November 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29155837/reduced-order-modeling-and-analysis-of-the-human-complement-system
#7
Adithya Sagar, Wei Dai, Mason Minot, Rachel LeCover, Jeffrey D Varner
Complement is an important pathway in innate immunity, inflammation, and many disease processes. However, despite its importance, there are few validated mathematical models of complement activation. In this study, we developed an ensemble of experimentally validated reduced order complement models. We combined ordinary differential equations with logical rules to produce a compact yet predictive model of complement activation. The model, which described the lectin and alternative pathways, was an order of magnitude smaller than comparable models in the literature...
2017: PloS One
https://www.readbyqxmd.com/read/29155814/optimal-synaptic-signaling-connectome-for-locomotory-behavior-in-caenorhabditis-elegans-design-minimizing-energy-cost
#8
Franciszek Rakowski, Jan Karbowski
The detailed knowledge of C. elegans connectome for 3 decades has not contributed dramatically to our understanding of worm's behavior. One of main reasons for this situation has been the lack of data on the type of synaptic signaling between particular neurons in the worm's connectome. The aim of this study was to determine synaptic polarities for each connection in a small pre-motor circuit controlling locomotion. Even in this compact network of just 7 neurons the space of all possible patterns of connection types (excitation vs...
November 20, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29155811/an-efficient-moments-based-inference-method-for-within-host-bacterial-infection-dynamics
#9
David J Price, Alexandre Breuzé, Richard Dybowski, Piero Mastroeni, Olivier Restif
Over the last ten years, isogenic tagging (IT) has revolutionised the study of bacterial infection dynamics in laboratory animal models. However, quantitative analysis of IT data has been hindered by the piecemeal development of relevant statistical models. The most promising approach relies on stochastic Markovian models of bacterial population dynamics within and among organs. Here we present an efficient numerical method to fit such stochastic dynamic models to in vivo experimental IT data. A common approach to statistical inference with stochastic dynamic models relies on producing large numbers of simulations, but this remains a slow and inefficient method for all but simple problems, especially when tracking bacteria in multiple locations simultaneously...
November 20, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29155758/methodology-for-developing-life-tables-for-sessile-insects-in-the-field-using-the-whitefly-bemisia-tabaci-in-cotton-as-a-model-system
#10
Steven E Naranjo, Peter C Ellsworth
Life tables provide a means of measuring the schedules of birth and death from populations over time. They also can be used to quantify the sources and rates of mortality in populations, which has a variety of applications in ecology, including agricultural ecosystems. Horizontal, or cohort-based, life tables provide for the most direct and accurate method of quantifying vital population rates because they follow a group of individuals in a population from birth to death. Here, protocols are presented for conducting and analyzing cohort-based life tables in the field that takes advantage of the sessile nature of the immature life stages of a global insect pest, Bemisia tabaci...
November 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155730/long-term-live-imaging-device-for-improved-experimental-manipulation-of-zebrafish-larvae
#11
Kayla Huemer, Jayne M Squirrell, Robert Swader, Kirsten Pelkey, Danny C LeBert, Anna Huttenlocher, Kevin W Eliceiri
The zebrafish larva is an important model organism for both developmental biology and wound healing. Further, the zebrafish larva is a valuable system for live high-resolution microscopic imaging of dynamic biological phenomena in space and time with cellular resolution. However, the traditional method of agarose encapsulation for live imaging can impede larval development and tissue regrowth. Therefore, this manuscript describes the zWEDGI (zebrafish Wounding and Entrapment Device for Growth and Imaging), which was designed and fabricated as a functionally compartmentalized device to orient larvae for high-resolution microscopy while permitting caudal fin transection within the device and subsequent unrestrained tail development and re-growth...
October 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155606/a-new-framework-for-analysis-of-coevolutionary-systems-directed-graph-representation-and-random-walks
#12
Siang Yew Chong, Peter Tiňo, Jun He, Xin Yao
Studying coevolutionary systems in the context of simplified models (i.e. games with pairwise interactions between coevolving solutions modelled as self plays) re-mains an open challenge since the rich underlying structures associated with pairwise-comparison-based fitness measures are often not taken fully into account. Although cyclic dynamics have been demonstrated in several contexts (such as intransitivity in coevolutionary problems), there is no complete characterization of cycle structures and their effects on coevolutionary search...
November 20, 2017: Evolutionary Computation
https://www.readbyqxmd.com/read/29155593/dynamical-density-functional-theory-for-the-evaporation-of-droplets-of-nanoparticle-suspension
#13
Christopher Chalmers, Roger Smith, Andrew J Archer
We develop a lattice gas model for the drying of droplets of a nanoparticle suspension on a planar surface, using dynamical density functional theory (DDFT) to describe the time evolution of the solvent and nanoparticle density profiles. The DDFT assumes a diffusive dynamics but does not include the advective hydrodynamics of the solvent, so the model is relevant to highly viscous or near to equilibrium systems. Nonetheless, we see an equivalent of the coffee-ring stain effect, but in the present model it occurs for thermodynamic rather the fluid-mechanical reasons...
November 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29155284/the-dynamic-evolution-of-drosophila-innubila-nudivirus
#14
Tom Hill, Robert L Unckless
Viruses coevolve with their hosts to overcome host resistance and gain the upper hand in the evolutionary arms race. Drosophila innubila nudivirus (DiNV) is a double stranded DNA virus, closely related to Oryctes rhinoceros nudivirus (OrNV) and Kallithea virus. DiNV is the first DNA virus found to naturally infect Drosophila and therefore has the potential to be developed as a model for DNA virus immune defense and host/virus coevolution within its well-studied host system. Here we sequence and annotate the genome of DiNV and identify signatures of adaptation, revealing clues for genes involved in host-parasite coevolution...
November 16, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29154574/a-multivariate-dynamic-systems-model-for-psychotherapy-with-more-than-one-client
#15
Jonathan E Butner, Carlene Deits-Lebehn, Alexander O Crenshaw, Travis J Wiltshire, Nicholas S Perry, Robert G Kent de Grey, Jasara N Hogan, Timothy W Smith, Katherine J W Baucom, Brian R W Baucom
The dynamics of the give and take between therapist and client(s) is frequently of interest to therapy process researchers. Characterizing the ways that therapists respond to clients and clients respond to therapists can be challenging in therapeutic encounters involving a single therapist and a single client. The complexity of this challenge increases as the number of people involved in a therapeutic encounter increases not only because there are more people responding to one another but also because the patterns of responding can become more complex...
November 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29154565/exploring-the-idiographic-dynamics-of-mood-and-anxiety-via-network-analysis
#16
Aaron J Fisher, Jonathan W Reeves, Glenn Lawyer, John D Medaglia, Julian A Rubel
Individual variation is increasingly recognized as important to psychopathology research. Concurrently, new methods of analysis based on network models are bringing new perspectives on mental (dys)function. This current work analyzed idiographic multivariate time series data using a novel network methodology that incorporates contemporaneous and lagged associations in mood and anxiety symptomatology. Data were taken from 40 individuals with generalized anxiety disorder (GAD), major depressive disorder (MDD), or comorbid GAD and MDD, who answered questions about 21 descriptors of mood and anxiety symptomatology 4 times a day over a period of approximately 30 days...
November 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29154393/using-participatory-system-dynamics-modeling-to-examine-the-local-hiv-test-and-treatment-care-continuum-in-order-to-reduce-community-viral-load
#17
Margaret R Weeks, Jianghong Li, David Lounsbury, Helena Danielle Green, Maryann Abbott, Marcie Berman, Lucy Rohena, Rosely Gonzalez, Shawn Lang, Heather Mosher
Achieving community-level goals to eliminate the HIV epidemic requires coordinated efforts through community consortia with a common purpose to examine and critique their own HIV testing and treatment (T&T) care system and build effective tools to guide their efforts to improve it. Participatory system dynamics (SD) modeling offers conceptual, methodological, and analytical tools to engage diverse stakeholders in systems conceptualization and visual mapping of dynamics that undermine community-level health outcomes and identify those that can be leveraged for systems improvement...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154037/sex-and-age-specific-modulation-of-brain-gaba-levels-in-a-mouse-model-of-alzheimer-s-disease
#18
Upasana Roy, Lara Stute, Corinna Höfling, Maike Hartlage-Rübsamen, Jörg Matysik, Steffen Roβner, A Alia
Age and sex are risk factors of Alzheimer's disease (AD). Among the neurotransmitter systems, gamma-aminobutyric acid (GABA) has been implicated in AD pathogenesis but the relevance of sex-specific GABAergic dysfunction during AD progression remains unknown. In the present study, we utilized state-of-the-art high-resolution magic angle spinning nuclear magnetic resonance to systematically monitor the brain region-, age-, and sex-specific modulation of GABA levels in wild-type and Tg2576 mice with amyloid pathology...
October 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29153876/real-time-evaluation-of-natural-organic-matter-deposition-processes-onto-model-environmental-surfaces
#19
Wenlu Li, Peng Liao, Trey Oldham, Yi Jiang, Chao Pan, Songhu Yuan, John D Fortner
Natural organic matter (NOM) is ubiquitous in aqueous systems and dynamically partitions onto/from environmental surfaces. However, such interfacial processes have not been uniformly quantified in situ and in real time. In this work, adsorption and deposition processes of Suwannee River humic acid (SRHA) and Suwannee River fulvic acid (SRFA), as model NOM, were evaluated for a series of environmentally relevant interfaces. Real-time, interfacial phenomenon, including deposition, release, and adlayer viscoelastic properties, were quantified over a variety of water chemistries via quartz crystal microbalance with dissipation monitoring (QCM-D)...
November 9, 2017: Water Research
https://www.readbyqxmd.com/read/29153707/the-influence-of-muscle-activation-on-impact-dynamics-during-lateral-falls-on-the-hip
#20
Daniel R Martel, Iris C Levine, Steven P Pretty, Andrew C Laing
Muscle activation has been demonstrated to influence impact dynamics during scenarios including running, automotive impacts, and head impacts. This study investigated the effects of targeted muscle activation magnitude on impact dynamics during low energy falls on the hip with human volunteers. Fifteen university-aged participants (eight females, seven males) underwent 12 lateral pelvis release trials. Half of the trials were muscle-'relaxed'; in the remaining 'contracted' trials participants isometrically contracted their gluteus medius to 20-30% of maximal voluntary contraction before the drop was initiated onto a force plate...
November 10, 2017: Journal of Biomechanics
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