keyword
MENU ▼
Read by QxMD icon Read
search

system dynamic model

keyword
https://www.readbyqxmd.com/read/29786742/a-novel-alendronate-functionalized-nanoprobe-for-simple-colorimetric-detection-of-cancer-associated-hypercalcemia
#1
Abhishek Sahu, Youngmin Hwang, Cristian Vilos, Jong-Min Lim, Sunghyun Kim, Won Il Choi, Giyoong Tae
The calcium (Ca2+) ion concentration in the blood serum is tightly regulated, and any abnormalities in the level of serum calcium ions are associated with many potentially dangerous diseases. Thus, monitoring of the Ca2+ ion concentration in the blood serum is of fundamental importance. Gold nanoparticle (GNP)-based colorimetric biosensors have enormous potential in clinical diagnostic applications due to their simplicity, versatility, and unique optical properties. In this study, we have developed an alendronate functionalized gold nanoparticle (GNP-ALD) system for the measurement of Ca2+ ion concentration in biological samples...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786740/shear-density-coupling-for-a-compressible-single-component-yield-stress-fluid
#2
Markus Gross, Fathollah Varnik
Flow behavior of a single-component yield stress fluid is addressed on the hydrodynamic level. A basic ingredient of the model is a coupling between fluctuations of density and velocity gradient via a Herschel-Bulkley-type constitutive model. Focusing on the limit of low shear rates and high densities, the model approximates well-but is not limited to-gently sheared hard sphere colloidal glasses, where solvent effects are negligible. A detailed analysis of the linearized hydrodynamic equations for fluctuations and the resulting cubic dispersion relation reveals the existence of a range of densities and shear rates with growing flow heterogeneity...
May 22, 2018: Soft Matter
https://www.readbyqxmd.com/read/29786727/rational-design-of-multi-functional-gold-nanoparticles-with-controlled-biomolecule-adsorption-a-multi-method-approach-for-in-depth-characterization
#3
Isaac Ojea-Jiménez, Robin Capomaccio, Inês Osório, Dora Mehn, Giacomo Ceccone, Rohanah Hussain, Giuliano Siligardi, Pascal Colpo, François Rossi, Douglas Gilliland, Luigi Calzolai
Multi-functionalized nanoparticles are of great interest in biotechnology and biomedicine, especially for diagnostic and therapeutic purposes. However, at the moment the characterization of complex, multi-functional nanoparticles is still challenging and this hampers the development of advanced nanomaterials for biological applications. In this work, we have designed a model system consisting of gold nanoparticles functionalized with two differentially-terminated poly(ethylene oxide) ligands, providing both "stealth" properties and protein-binding capabilities to the nanoparticles...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786724/influence-of-a-nanoparticle-on-the-structure-and-dynamics-of-model-ionomer-melts
#4
Janani Sampath, Lisa M Hall
We simulate a single spherical nanoparticle (NP) surrounded by partially neutralized ionomers. The coarse-grained ionomers consist of a linear backbone of neutral monomer beads with charged pendant beads and counterions, along with pendant 'sticker' beads that represent unneutralized acid groups. Two different NP interactions are considered; one in which the NP interacts uniformly with all beads in the system (neutral NP) and another in which the NP has higher cohesive interactions with ions and stickers (sticky NP)...
May 22, 2018: Soft Matter
https://www.readbyqxmd.com/read/29786698/a-reconstruction-of-global-hydroclimate-and-dynamical-variables-over-the-common-era
#5
Nathan J Steiger, Jason E Smerdon, Edward R Cook, Benjamin I Cook
Hydroclimate extremes critically affect human and natural systems, but there remain many unanswered questions about their causes and how to interpret their dynamics in the past and in climate change projections. These uncertainties are due, in part, to the lack of long-term, spatially resolved hydroclimate reconstructions and information on the underlying physical drivers for many regions. Here we present the first global reconstructions of hydroclimate and associated climate dynamical variables over the past two thousand years...
May 22, 2018: Scientific Data
https://www.readbyqxmd.com/read/29786472/high-speed-fluoroscopy-used-to-measure-dynamic-spinal-cord-deformation-in-an-in-vivo-rat-model
#6
Erin Lucas, Tom Whyte, Jie Liu, Colin M Russell, Wolfram Tetzlaff, Peter Alec Cripton
While spinal cord deformation is thought to be a predictor of spinal cord injury severity, few researchers have directly investigated the dynamic cord deformation or distribution of the deformation between white and grey matter of the in vivo spinal cord during impact. This knowledge would help to establish correlations among impact parameters, internal spinal cord deformation, and histological and functional outcomes. Relying on surface deformations alone may not be a sufficient representation of spinal cord deformation...
May 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29786422/mechanisms-regulating-the-association-of-protein-phosphatase-1-with-spinophilin-and-neurabin
#7
Michael C Edler, Asma B Salek, Darryl S Watkins, Harjot Kaur, Cameron W Morris, Bryan K Yamamoto, Anthony J Baucum
Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase catalytic subunits are much more promiscuous in their ability to dephosphorylate substrates. To obtain substrate specificity, serine/threonine phosphatases utilize targeting proteins to regulate phosphatase subcellular localization and catalytic activity. Spinophilin and its homolog neurabin are two of the most abundant dendritic spine-localized protein phosphatase 1 (PP1) targeting proteins...
May 22, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29785787/expanding-systems-thinking-incorporating-tools-from-medical-sociology-into-mft-education-and-research
#8
Joy Heafner, Laura Mauldin
The field of marriage and family therapy has historically focused on dynamics within family systems, and at times the role of social and cultural factors external to the family. To date, however, little scholarship has examined how therapists themselves are embedded within a mental healthcare system. The purpose of this article is to demonstrate how structural components of the mental healthcare system shape the practice of therapy. We draw from the field of medical sociology to illustrate how three dominant structures-managed care, diagnosis, and evidence-based models-are intertwining and mutually reinforcing systems that have significant and long-term implications for systemic therapists and researchers...
May 21, 2018: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/29785519/threshold-dynamics-of-a-temperature-dependent-stage-structured-mosquito-population-model-with-nested-delays
#9
Xiunan Wang, Xingfu Zou
Mosquito-borne diseases remain a significant threat to public health and economics. Since mosquitoes are quite sensitive to temperature, global warming may not only worsen the disease transmission case in current endemic areas but also facilitate mosquito population together with pathogens to establish in new regions. Therefore, understanding mosquito population dynamics under the impact of temperature is considerably important for making disease control policies. In this paper, we develop a stage-structured mosquito population model in the environment of a temperature-controlled experiment...
May 21, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29785241/an-in-vivo-zebrafish-model-for-interrogating-ros-mediated-pancreatic-%C3%AE-cell-injury-response-and-prevention
#10
Abhishek A Kulkarni, Abass M Conteh, Cody A Sorrell, Anjali Mirmira, Sarah A Tersey, Raghavendra G Mirmira, Amelia K Linnemann, Ryan M Anderson
It is well known that a chronic state of elevated reactive oxygen species (ROS) in pancreatic β -cells impairs their ability to release insulin in response to elevated plasma glucose. Moreover, at its extreme, unmitigated ROS drives regulated cell death. This dysfunctional state of ROS buildup can result both from genetic predisposition and environmental factors such as obesity and overnutrition. Importantly, excessive ROS buildup may underlie metabolic pathologies such as type 2 diabetes mellitus. The ability to monitor ROS dynamics in β -cells in situ and to manipulate it via genetic, pharmacological, and environmental means would accelerate the development of novel therapeutics that could abate this pathology...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29782540/monte-carlo-simulations-of-microtubule-arrays-the-critical-roles-of-rescue-transitions-the-cell-boundary-and-tubulin-concentration-in-shaping-microtubule-distributions
#11
Lynne Cassimeris, Jessica C Leung, David J Odde
Microtubules are dynamic polymers required for a number of processes, including chromosome movement in mitosis. While regulators of microtubule dynamics have been well characterized, we lack a convenient way to predict how the measured dynamic parameters shape the entire microtubule system within a cell, or how the system responds when specific parameters change in response to internal or external signals. Here we describe a Monte Carlo model to simulate an array of dynamic microtubules from parameters including the cell radius, total tubulin concentration, microtubule nucleation rate from the centrosome, and plus end dynamic instability...
2018: PloS One
https://www.readbyqxmd.com/read/29782246/precision-medicine-and-radiogenomics-in-breast-cancer-new-approaches-toward-diagnosis-and-treatment
#12
Katja Pinker, Joanne Chin, Amy N Melsaether, Elizabeth A Morris, Linda Moy
Precision medicine is medicine optimized to the genotypic and phenotypic characteristics of an individual and, when present, his or her disease. It has a host of targets, including genes and their transcripts, proteins, and metabolites. Studying precision medicine involves a systems biology approach that integrates mathematical modeling and biology genomics, transcriptomics, proteomics, and metabolomics. Moreover, precision medicine must consider not only the relatively static genetic codes of individuals, but also the dynamic and heterogeneous genetic codes of cancers...
June 2018: Radiology
https://www.readbyqxmd.com/read/29782172/assembly-dynamics-of-plasmonic-dna-capped-gold-nanoparticle-monolayers
#13
Thomas L Derrien, Michelle Zhang, Patrick Dorion, Detlef-M Smilgies, Dan Luo
The self-assembly of nanoparticles in aqueous solutions promises wide applications but requires the careful balance of many parameters not present in organic solvents. While the presence of long-range electrostatic interactions in aqueous solutions may complicate such assemblies, they provide additional parameters through which to control self-assembly. Here, with DNA-capped gold nanoparticles and through variation of the ionic strength in aqueous solutions, we explored the influence of electrostatic interactions on the adsorption of negatively charged nanoparticles on a positively charged surface...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29781187/eeg-oscillations-during-caress-like-affective-haptic-elicitation
#14
Gaetano Valenza, Alberto Greco, Matteo Bianchi, Mimma Nardelli, Simone Rossi, Enzo Pasquale Scilingo
Noninvasive, objective quantitative techniques to gauge emotional states are fundamental for clinical psychology as they overcome subjective bias of currently used questionnaires. To this end, we investigated brain oscillatory EEG activity during caresslike, affective haptic elicitation conveyed on the forearm at two force (strength of the caress) and three velocity (velocity of the caress) levels. Thirty-two healthy subjects (16 female) were asked to assess each haptic stimulus in terms of arousal (i.e., intensity of emotional perception) and valence (i...
May 20, 2018: Psychophysiology
https://www.readbyqxmd.com/read/29780992/electrostatic-interactions-in-soft-particle-systems-mesoscale-simulations-of-ionic-liquids
#15
Yong-Lei Wang, You-Liang Zhu, Zhong-Yuan Lu, Aatto Laaksonen
Computer simulations provide a unique insight into the microscopic details, molecular interactions and dynamic behavior responsible for many distinct physicochemical properties of ionic liquids. Due to the sluggish and heterogeneous dynamics and the long-ranged nanostructured nature of ionic liquids, coarse-grained meso-scale simulations provide an indispensable complement to detailed first-principles calculations and atomistic simulations allowing studies over extended length and time scales with a modest computational cost...
May 21, 2018: Soft Matter
https://www.readbyqxmd.com/read/29780793/an-exponential-regression-model-reveals-the-continuous-development-of-b-cell-subpopulations-used-as-reference-values-in-children
#16
Christoph Königs, Stephan Schultze-Strasser, Andrea Quaiser, Konrad Bochennek, Dirk Schwabe, Thomas E Klingebiel, Ulrike Koehl, Claudia Cappel, Udo Rolle, Peter Bader, Melanie Bremm, Sabine Huenecke, Shahrzad Bakhtiar
B lymphocytes are key players in humoral immunity, expressing diverse surface immunoglobulin receptors directed against specific antigenic epitopes. The development and profile of distinct subpopulations have gained awareness in the setting of primary immunodeficiency disorders, primary or secondary autoimmunity and as therapeutic targets of specific antibodies in various diseases. The major B cell subpopulations in peripheral blood include naïve (CD19+ or CD20+ IgD+ CD27- ), non-switched memory (CD19+ or CD20+ IgD+ CD27+ ) and switched memory B cells (CD19+ or CD20+ IgD- CD27+ )...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29780562/kinetic-studies-on-strand-displacement-in-de-novo-designed-parallel-heterodimeric-coiled-coils
#17
Mike C Groth, W Mathis Rink, Nils F Meyer, Franziska Thomas
Among the protein folding motifs, which are accessible by de novo design, the parallel heterodimeric coiled coil is most frequently used in bioinspired applications and chemical biology in general. This is due to the straightforward sequence-to-structure relationships, which it has in common with all coiled-coil motifs, and the heterospecificity, which allows control of association. Whereas much focus was laid on designing orthogonal coiled coils, systematic studies on controlling association, for instance by strand displacement, are rare...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780495/examining-the-chemical-and-structural-properties-that-influence-the-sensitivity-of-energetic-nitrate-esters
#18
Virginia W Manner, Marc J Cawkwell, Edward M Kober, Thomas W Myers, Geoff W Brown, Hongzhao Tian, Christopher J Snyder, Romain Perriot, Daniel N Preston
The sensitivity of explosives is controlled by factors that span from intrinsic chemical reactivity and chemical intramolecular effects to mesoscale structure and defects, and has been a topic of extensive study for over 50 years. Due to these complex competing chemical and physical elements, a unifying relationship between molecular framework, crystal structure, and sensitivity has yet to be developed. In order to move towards this goal, ideally experimental studies should be performed on systems with small, systematic structural modifications, with modeling utilized to interpret experimental results...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780184/pore-scale-hydrodynamics-in-a-progressively-bioclogged-three-dimensional-porous-medium-3-d-particle-tracking-experiments-and-stochastic-transport-modeling
#19
M Carrel, V L Morales, M Dentz, N Derlon, E Morgenroth, M Holzner
Biofilms are ubiquitous bacterial communities that grow in various porous media including soils, trickling, and sand filters. In these environments, they play a central role in services ranging from degradation of pollutants to water purification. Biofilms dynamically change the pore structure of the medium through selective clogging of pores, a process known as bioclogging. This affects how solutes are transported and spread through the porous matrix, but the temporal changes to transport behavior during bioclogging are not well understood...
March 2018: Water Resources Research
https://www.readbyqxmd.com/read/29780181/dust-control-by-air-blocking-shelves-and-dust-collector-to-bailing-airflow-ratios-for-a-surface-mine-drill-shroud
#20
Y Zheng, W R Reed, J D Potts, M Li, J P Rider
The National Institute for Occupational Safety and Health (NIOSH) recently developed a series of validated models utilizing computational fluid dynamics (CFD) to study the effects of air-blocking shelves on airflows and respirable dust distribution associated with medium-sized surface blasthole drill shrouds as part of a dry dust collector system. Using validated CFD models, three different air-blocking shelves were included in the present study: a 15.2-cm (6-in.)-wide shelf; a 7.6-cm (3-in.)-wide shelf; and a 7...
May 2018: Mining Engineering
keyword
keyword
98610
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"