Lanfen An, Kejun Dong, Shuqi Chi, Sitian Wei, Jun Zhang, Zhicheng Yu, Qian Zhang, Tangansu Zhang, Shuangshuang Cheng, Rui Shi, Zhishan Jin, Xing Zhou, Yingchao Zhao, Hongbo Wang
Long noncoding RNA urothelial carcinoma associated 1 (UCA1) has been identified as a key molecule in human cancers. However, its functional implications remain unspecified in the context of cervical cancer (CC). This research aims to identify the regulatory mechanism of UCA1 in CC. UCA1 was identified through microarray and confirmed through a quantitative real-time polymerase chain reaction. Proteins that bind with UCA1 were recognized using RNA pull-down assays along with RNA immunoprecipitation. Ubiquitination assays and coimmunoprecipitation were performed to explore the molecular mechanisms of the SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 3 (SMARCD3) downregulated in CC...
December 20, 2023: Molecular Carcinogenesis