keyword
https://read.qxmd.com/read/32768545/current-outcomes-of-blunt-vertebral-artery-injuries
#21
JOURNAL ARTICLE
Andrew Sticco, Sagar S Gandhi, Bryan Knoedler, Geoff Marston, Alex Ewing, Eugene M Langan, Christopher G Carsten
BACKGROUND: There is no consensus on the treatment of blunt vertebral artery injuries, and studies are limited to small case series. We assessed the natural history and current management of these injuries. METHODS: We performed a retrospective study of a prospectively collected registry at a level I trauma center over a 5-year period. Additional information was gathered from patient charts and imaging review from electronic medical records. We analyzed demographics, mechanism of injury, Glasgow Coma Score, mortality, length of stay, associated injuries, Denver grading scale, neurological findings, level and laterality of injury, delay in diagnosis, treatment, and follow-up imaging...
January 2021: Annals of Vascular Surgery
https://read.qxmd.com/read/32756962/patients-with-men1-are-at-an-increased-risk-for-venous-thromboembolism
#22
JOURNAL ARTICLE
Maya E Lee, Yashira M Ortega-Sustache, Sunita K Agarwal, Aisha Tepede, James Welch, Adel Mandl, Rashika Bansal, Amit Tirosh, Paolo Piaggi, Craig Cochran, William F Simonds, Lee S Weinstein, Jenny E Blau
BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder predisposing the development of multiple functional and nonfunctional neuroendocrine tumors (NETs). Only uncommon MEN1-associated functional NETs such as glucagonomas (<1%) and adenocorticotropic hormone-producing tumors (<5%) are known to be associated with hypercoagulability. It is unknown if patients with MEN1 generally have an increased risk of venous thromboembolism (VTE). METHODS: We queried a prospective natural history study of germline mutation-positive MEN1 patients (n = 286) between 1991 and 2019 for all lifetime events of VTE...
January 23, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31091758/anticoagulant-activity-of-sulfated-ulvan-isolated-from-the-green-macroalga-ulva-rigida
#23
JOURNAL ARTICLE
Amandine Adrien, Antoine Bonnet, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, Nicolas Bridiau
(1) Background: Brown and red algal sulfated polysaccharides have been widely described as anticoagulant agents. However, data on green algae, especially on the Ulva genus, are limited. This study aimed at isolating ulvan from the green macroalga Ulva rigida using an acid- and solvent-free procedure, and investigating the effect of sulfate content on the anticoagulant activity of this polysaccharide. (2) Methods: The obtained ulvan fraction was chemically sulfated, leading to a doubling of the polysaccharide sulfate content in a second ulvan fraction...
May 14, 2019: Marine Drugs
https://read.qxmd.com/read/30987427/comparison-of-low-molecular-weight-heparins-prepared-from-ovine-heparins-with-enoxaparin
#24
JOURNAL ARTICLE
Jianle Chen, Yanlei Yu, Jawed Fareed, Debra Hoppensteadt, Walter Jeske, Ahmed Kouta, Caijuan Jin, Yongsheng Jin, Yiming Yao, Ke Xia, Fuming Zhang, Shiguo Chen, Xingqian Ye, Robert J Linhardt
Heparin and its low-molecular-weight heparin derivatives are widely used clinical anticoagulants. These drugs are critical for the practice of medicine in applications, including kidney dialysis, cardiopulmonary bypass, and in the management of venous thromboembolism. Currently, these drugs are derived from livestock, primarily porcine intestine and less frequently bovine intestine and bovine lung. The worldwide dependence on the pig as a single dominant animal species has made the supply chain for this critical drug quite fragile, leading to the search for other sources of these drugs, including the expanded use of bovine tissues...
January 2019: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/30153117/trends-in-deep-vein-thrombosis-prophylaxis-and-deep-vein-thrombosis-rates-after-total-hip-and-knee-arthroplasty
#25
JOURNAL ARTICLE
Harpreet Bawa, Jack W Weick, Douglas R Dirschl, Hue H Luu
INTRODUCTION: Patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) are at high risk of deep vein thrombosis (DVT) postoperatively, necessitating the use of prophylaxis medications. This investigation used a large claims database to evaluate trends in postoperative DVT prophylaxis and rates of DVT within 6 months after THA or TKA. METHODS: Truven Health MarketScan Commercial Claims and Encounters and Medicare Supplemental and Coordination of Benefits databases were reviewed from 2004 to 2013 for patients who underwent THA or TKA...
October 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://read.qxmd.com/read/30010055/transvenous-lead-extraction-during-uninterrupted-warfarin-therapy-feasibility-and-outcomes
#26
JOURNAL ARTICLE
Qi Zheng, Melanie Maytin, Roy M John, Ammar M Killu, Laurence M Epstein
BACKGROUND: Uninterrupted anticoagulation is important for patients at high risk for thromboembolism. Bridging with heparin/enoxaparin increases the risk of hematoma and infection. There are no published data on the feasibility of transvenous lead extraction (TLE) during uninterrupted anticoagulation. OBJECTIVE: The purpose of this study was to examine the feasibility and safety of TLE during uninterrupted warfarin therapy with therapeutic international normalized ratio (INR)...
December 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/29976241/symptomatic-bilateral-pulmonary-embolism-without-deep-venous-thrombosis-in-an-adolescent-following-arthroscopic-anterior-cruciate-ligament-reconstruction-a-case-report-and-review-of-the-literature
#27
REVIEW
Jonathan Bourget-Murray, Mathew A Clarke, Sydney Gorzitza, Lisa A Phillips
BACKGROUND: Venous thromboembolism, specifically pulmonary embolism, is a rare complication following elective pediatric orthopedic surgery. Bilateral pulmonary embolism with associated pulmonary hemorrhage/infarct without concomitant deep vein thrombosis has never been reported following routine anterior cruciate ligament reconstruction in an adolescent. CASE PRESENTATION: A 16-year-old white girl presented with acute onset shortness of breath and pleuritic chest pain 6 days following elective anterior cruciate ligament reconstruction...
July 6, 2018: Journal of Medical Case Reports
https://read.qxmd.com/read/29560388/enoxaparin-induced-skin-necrosis-at-injection-site-after-total-knee-arthroplasty
#28
JOURNAL ARTICLE
Max Haffner, Nasser Heyrani, John P Meehan, Mauro Giordani
Enoxaparin is a widely used low-molecular-weight heparin for perioperative thromboembolic prophylaxis. Enoxaparin-induced skin necrosis in the setting of arthroplasty has been rarely reported in the literature with varying outcomes and management decisions. Our patient developed skin necrosis at his injection site and thrombocytopenia 10 days following left total knee arthroplasty surgery and after receiving subcutaneous Lovenox injections postoperatively. The patient was started on an alternative anticoagulation based on a high suspicion for heparin-induced thrombocytopenia and the wound was monitored without surgical debridement...
March 2018: Arthroplasty Today
https://read.qxmd.com/read/29519571/sclerotherapy-for-intramuscular-vascular-malformations-a-single-center-experience
#29
JOURNAL ARTICLE
Federico Scorletti, Manish N Patel, Adrienne M Hammill, Kiersten W Ricci, Charles M Myer, Roshni Dasgupta
BACKGROUND: Vascular malformations isolated to skeletal muscles are rare and often debilitating due to pain and very challenging to treat. Multi-modal management options include compression garments, medical therapy, sclerotherapy, and surgical resection. METHODS: A retrospective review of patients who underwent sclerotherapy for intramuscular venous malformations (IVM) between 2008 and 2016 was performed. Demographics, indications, and clinical follow-up were analyzed...
May 2018: Journal of Pediatric Surgery
https://read.qxmd.com/read/29339133/antithrombin-iii-binding-site-analysis-of-low-molecular-weight-heparin-fractions
#30
JOURNAL ARTICLE
Yin Chen, Jing Zhao, Yanlei Yu, Xinyue Liu, Lei Lin, Fuming Zhang, Robert J Linhardt
Low-molecular-weight heparins (LMWHs) are widely used as clinical anticoagulant drugs. LMWHs are heterogeneous and highly negatively charged glycans prepared by chemical or enzymatic depolymerization of unfractionated heparin. The detailed structural analysis of a LMWH is essential for the drug quality control. In this study, an LMWH, enoxaparin sodium (a generic version of Lovenox) was separated into different molecular weight fractions by a Superdex peptide column. The disaccharide compositions, 3-O-sulfo group-containing tetrasaccharides composition, and antithrombin III-binding affinity of the fractions from this LMWH were analyzed...
May 2018: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/28414674/a-clot-possibly-due-to-loss-of-tnf-%C3%AE-supression
#31
JOURNAL ARTICLE
J Broussard, M Berlinger, D Lauret
INTRODUCTION: Inflammation and venous thrombosis enjoy a close Relationship. We present a patient who had multiple DVTs following the discontinuation of anti- TNF-α therapy. CASE: A 34 year old African American female with a history of multiple DVT's, miscarriages, and reported Crohn's disease presented with shortness of breath. In the Emergency Department, CTA showed bilateral pulmonary emboli. The patient had been off adalimumab for one year and reported abdominal pain with 6-7 non-bloody bowel movements daily...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://read.qxmd.com/read/28300869/e-selectin-inhibition-with-gmi-1271-decreases-venous-thrombosis-without-profoundly-affecting-tail-vein-bleeding-in-a-mouse-model
#32
JOURNAL ARTICLE
Dorian L Culmer, Misha L Dunbar, Angela E Hawley, Suman Sood, Robert E Sigler, Peter K Henke, Thomas W Wakefield, John L Magnani, Daniel D Myers
Selectins, such as E-selectin (CD62E), function in venous thrombosis by binding and activating immune cells to initiate the coagulation cascade. GMI-1271 is a small molecule antagonist that inhibits E-selectin activity. Here we determine whether inhibition of E-selectin is sufficient to decrease acute venous thrombosis and associated inflammatory events in both prophylactic and treatment protocols without significantly affecting haemostasis. Male C57BL/6 mice underwent surgery for experimental thrombosis induction and were harvested at peak thrombus formation in our animal model, two days post induction...
June 2, 2017: Thrombosis and Haemostasis
https://read.qxmd.com/read/28224913/parent-heparin-and-daughter-lmw-heparin-correlation-analysis-using-lc-ms-and-nmr
#33
JOURNAL ARTICLE
Xinyue Liu, Kalib St Ange, Xiaohua Wang, Lei Lin, Fuming Zhang, Lianli Chi, Robert J Linhardt
Heparin is a structurally complex, polysaccharide anticoagulant derived from livestock, primarily porcine intestinal tissues. Low molecular weight (LMW) heparins are derived through the controlled partial depolymerization of heparin. Increased manufacturing and regulatory concerns have provided the motivation for the development of more sophisticated analytical methods for determining both their structure and pedigree. A strategy, for the comprehensive comparison of parent heparins and their LMW heparin daughters, is described that relies on the analysis of monosaccharide composition, disaccharide composition, and oligosaccharide composition...
April 8, 2017: Analytica Chimica Acta
https://read.qxmd.com/read/28147712/evaluation-of-the-anticoagulant-potential-of-polysaccharide-rich-fractions-extracted-from-macroalgae
#34
JOURNAL ARTICLE
Amandine Adrien, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, Nicolas Bridiau
The aim of this study was to evaluate the potential anticoagulant activity of sulphated polysaccharide-containing extracts of six french edible marine macroalgae. Aqueous extracts of brown (Himanthalia elongata, Laminaria digitata, Ascophyllum nodosum, Fucus vesiculosus), green (Ulva lactuca) and red (Chondrus crispus) macroalgae were prepared and their biochemical properties were determined, including major biomolecules, sulphate and ash contents. The anticoagulant activity of each extract was investigated using different scales from the specific antithrombin-dependent pathway (anti-Xa and anti-IIa) to the intrinsic and/or common (Activated Partial Thromboplastin Time, APTT), extrinsic (Prothrombin Time, PT) or common (Thrombin Time, TT) anticoagulant pathways, and compared with those of commercial anticoagulants, heparin and Lovenox®...
September 2017: Natural Product Research
https://read.qxmd.com/read/28011077/top-down-and-bottom-up-analysis-of-commercial-enoxaparins
#35
JOURNAL ARTICLE
Xinyue Liu, Kalib St Ange, Lei Lin, Fuming Zhang, Lianli Chi, Robert J Linhardt
A strategy for the comprehensive analysis of low molecular weight (LMW) heparins is described that relies on using an integrated top-down and bottom-up approach. Liquid chromatography-mass spectrometry, an essential component of this approach, is rapid, robust, and amenable to automated processing and interpretation. Nuclear magnetic resonance spectroscopy provides complementary top-down information on the chirality of the uronic acid residues comprising a low molecular weight heparin. Using our integrated approach four different low molecular weight heparins prepared from porcine heparin through chemical β-eliminative cleavage were comprehensively analyzed...
January 13, 2017: Journal of Chromatography. A
https://read.qxmd.com/read/27965129/comparative-subcutaneous-repeated-toxicity-study-of-enoxaparin-products-in-rats
#36
COMPARATIVE STUDY
Zina Kobbi, Hazar Kraiem, Zakaria Benlasfar, Ammar Marouani, Taieb Massoud, Samir Boubaker, Balkiss Bouhaouala-Zahar, Nadia Fenina
Enoxaparin is a low-molecular-weight heparin widely used for the prevention and treatment of thromboembolism. With the development of several enoxaparin biosimilars, real medical concerns about their safety and efficacy have been raised. This repeated dose toxicity study consists of preclinical toxicological evaluation of a biosimilar biological version of enoxaparin, the drug product "Enoxa", compared to the enoxaparin reference drug product, "Lovenox". Eighty white Wistar rats were treated with "Enoxa" versus the reference product, using subcutaneous therapeutic and toxic doses, varying from 3...
March 2017: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/27942011/glyccompsoft-software-for-automated-comparison-of-low-molecular-weight-heparins-using-top-down-lc-ms-data
#37
JOURNAL ARTICLE
Xiaohua Wang, Xinyue Liu, Lingyun Li, Fuming Zhang, Min Hu, Fuji Ren, Lianli Chi, Robert J Linhardt
Low molecular weight heparins are complex polycomponent drugs that have recently become amenable to top-down analysis using liquid chromatography-mass spectrometry. Even using open source deconvolution software, DeconTools, and automatic structural assignment software, GlycReSoft, the comparison of two or more low molecular weight heparins is extremely time-consuming, taking about a week for an expert analyst and provides no guarantee of accuracy. Efficient data processing tools are required to improve analysis...
2016: PloS One
https://read.qxmd.com/read/27789095/deep-venous-thrombosis-prophylaxis-after-unicompartmental-knee-arthroplasty-a-prospective-study-on-the-safety-of-aspirin
#38
JOURNAL ARTICLE
Tom Schmidt-Braekling, Andrew D Pearle, David J Mayman, Geoffrey H Westrich, Wenzel Waldstein, Friedrich Boettner
BACKGROUND: Although venous thromboembolism is one of the leading causes of morbidity after knee arthroplasty, little data exist on the risk of deep venous thrombosis (DVT) after unicompartmental knee arthroplasty (UKA). METHODS: We prospectively enrolled 112 patients undergoing UKA to determine the incidence of DVT utilizing aspirin 325 mg twice a day (BID) for 4 weeks postoperatively as DVT prophylaxis. The data were compared with a recent randomized controlled trial of patients undergoing total knee arthroplasty utilizing aspirin and Lovenox in conjunction with pneumatic compression devices...
March 2017: Journal of Arthroplasty
https://read.qxmd.com/read/27624773/heparin-and-lovenox-what-the-oral-and-maxillofacial-surgeon-needs-to-know
#39
REVIEW
LisaMarie Di Pasquale, Elie M Ferneini
For the oral and maxillofacial surgeon, many patients will be on heparin products during surgery. So far, there is no standardized approach to treating anticoagulated patients during oral and maxillofacial surgical procedures. When a patient is on heparin therapy, heparin may be stopped 4 to 6 hours before surgery and resumed once hemostasis is achieved, usually within 24 hours. If low-molecular-weight heparin is administered, the treatment is generally stopped at least 12 hours before surgery and then resumed in a similar fashion...
November 2016: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/27609724/omnious-t-wave-inversions-wellens-syndrome-revisited
#40
Swe Zin Mar Win Htut Oo, Koroush Khalighi, Archana Kodali, Cho May, Thein Tun Aung, Richard Snyder
Wellens' syndrome is characterized by T-wave changes in electrocardiogram (EKG) during pain-free period in a patient with intermittent angina chest pain. It carries significant diagnostic and prognostic value because this syndrome represents a pre-infarction stage of coronary artery disease involving proximal left anterior descending (LAD) artery, which can subsequently lead to extensive anterior myocardial infarctions (MIs) and even death without coronary angioplasty. Therefore, it is crucial for every physician to recognize EKG features of Wellens' syndrome in order to take appropriate immediate intervention to reduce mortality and morbidity for MI...
2016: Journal of Community Hospital Internal Medicine Perspectives
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