Jianle Chen, Yanlei Yu, Jawed Fareed, Debra Hoppensteadt, Walter Jeske, Ahmed Kouta, Caijuan Jin, Yongsheng Jin, Yiming Yao, Ke Xia, Fuming Zhang, Shiguo Chen, Xingqian Ye, Robert J Linhardt
Heparin and its low-molecular-weight heparin derivatives are widely used clinical anticoagulants. These drugs are critical for the practice of medicine in applications, including kidney dialysis, cardiopulmonary bypass, and in the management of venous thromboembolism. Currently, these drugs are derived from livestock, primarily porcine intestine and less frequently bovine intestine and bovine lung. The worldwide dependence on the pig as a single dominant animal species has made the supply chain for this critical drug quite fragile, leading to the search for other sources of these drugs, including the expanded use of bovine tissues...
January 2019: Clinical and Applied Thrombosis/hemostasis