keyword
https://read.qxmd.com/read/38490954/prophylactic-enoxaparin-dosing-using-anti-factor-xa-levels-in-hepatic-surgery-patients-a-pilot-study
#1
JOURNAL ARTICLE
Samuel Coster, Ali Shammout, Michael Chaney, Kyra Folkert, Kent Grosh, Saad Shebrain, Gitonga Munene
This study examines the safety and efficacy of using peak anti-Xa levels to achieve prophylactic enoxaparin (Lovenox, Sanofi-Aventis) levels in patients who underwent hepatic surgery. Prospectively enrolled patients undergoing major and minor hepatic procedures received postoperative enoxaparin dosing. The enoxaparin dose was adjusted to attain a peak anti-Xa level ≥ 0.20 U/ml. This group was compared to a historical cohort of patients who underwent similar procedures and received standard postoperative VTE chemoprophylaxis dosing...
March 15, 2024: American Surgeon
https://read.qxmd.com/read/38195313/routine-extended-30-days-chemoprophylaxis-for-patients-undergoing-laparoscopic-sleeve-gastrectomy-may-reduce-portomesenteric-vein-thrombosis-rates
#2
JOURNAL ARTICLE
Dylan Cuva, Eduardo Somoza, Moyosore Alade, John K Saunders, Julia Park, Jeffrey Lipman, Peter Einersen, Patricia Chui, Manish Parikh
BACKGROUND: Venous thromboembolism (VTE), including Portomesenteric vein thrombosis (PMVT), is a major complication of sleeve gastrectomy (SG). We changed our practice in July 2021 to routinely discharge all SG patients postoperatively with extended chemoprophylaxis for 30 days. OBJECTIVES: Evaluate the efficacy and safety of routine extended chemoprophylaxis compared to 2 prior timeframes using selective extended chemoprophylaxis. SETTING: University Hospital...
December 10, 2023: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/37532121/scientific-considerations-in-the-regulatory-approval-of-generic-or-biosimilar-version-of-enoxaparin-sodium-a-lifesaving-carbohydrate-polymer
#3
REVIEW
Zarina Iqbal, Saima Sadaf
Enoxaparin sodium (Clexane®/Klexane®/Lovenox®) is one amongst the few drugs that have assumed a central role as drug of treatment and/or prevention against thromboembolic complications during COVID-19. The increase in demand resulting in many generic (or biosimilar) versions entering the market has increased the risks of quality and safety (including immunogenicity) related issues. Under the circumstances, development of stringent regulatory approaches has received much attention as investigation of new drug delivery systems for improved therapeutic activity...
July 31, 2023: Regulatory Toxicology and Pharmacology: RTP
https://read.qxmd.com/read/37353413/extended-postoperative-venous-thromboembolism-prophylaxis-after-bariatric-surgery-a-comparison-of-existing-risk-stratification-tools-and-5-year-mbsaqip-analysis
#4
JOURNAL ARTICLE
Joseph R Imbus, Andrew D Jung, S Davis, Omobolanle O Oyefule, Ankit D Patel, Federico J Serrot, Jamil L Stetler, Melissa C Majumdar, Dominic Papandria, Maggie L Diller, Jahnavi K Srinivasan, Edward Lin, Elizabeth M Hechenbleikner
BACKGROUND: Venous thromboembolism (VTE) is a leading cause of 30-day mortality after metabolic and bariatric surgery (MBS). Multiple predictive tools exist for VTE risk assessment and extended VTE chemoprophylaxis determination. OBJECTIVE: To review existing risk-stratification tools and compare their predictive abilities. SETTING: MBSAQIP database. METHODS: Retrospective analysis of the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database was performed (2015-2019) for primary minimally invasive MBS cases...
August 2023: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/37343269/sharps-injuries-with-lovenox-and-generic-enoxaparin-prefilled-safety-syringes-a-12-year-retrospective-cross-sectional-analytical-study
#5
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2023: Nursing
https://read.qxmd.com/read/37314028/thromboembolism-triggered-by-a-combination-of-electronic-cigarettes-and-oral-contraceptives-a-case-report-and-review-of-literature
#6
JOURNAL ARTICLE
Olaniyi Fadeyi, Anantbir Randhawa, Abhirami Shankar, Christine Garabetian, Harpreet Singh, Antonio Topacio
Genetic predisposition, oral contraceptive (OCP) use, tobacco smoking, cancers, and trauma are well-known triggers for hypercoagulability and thromboembolism. Multiple reports have been published on the health risk of combining OCP and traditional cigarettes smoking in the context of thromboembolism. However, limited information is available on the health consequences of combining OCP use with electronic cigarettes. Here, we report a case of a young female patient with a past medical history of ovarian cysts and electronic cigarettes use who came into the hospital with a complaint of "recurrent seizures" and tachycardia...
2023: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/37212821/sharps-injuries-with-lovenox-and-generic-enoxaparin-prefilled-safety-syringes-a-12-year-retrospective-cross-sectional-analytical-study
#7
JOURNAL ARTICLE
Terry Grimmond, Maryann Gruden, Bobbi Jo Hurst, Lydia F Crutchfield
PURPOSE: Investigate the incidence and mechanisms of sharps injuries (SI) to staff using Lovenox and generic enoxaparin prefilled syringes. METHODS: Four national adverse event databases were examined over a 12-year period for incidence and brands involved with injury events to staff using enoxaparin prefilled syringes. RESULTS: The search revealed 581 adverse events (including 20 sharps injuries) associated with device malfunction in 8 of 16 brands, with one brand mentioned significantly more frequently than others...
June 1, 2023: Nursing
https://read.qxmd.com/read/37180701/low-molecular-weight-heparin-in-covid-19-benefits-and-concerns
#8
REVIEW
Adham Makarem, Rana Zareef, Joseph Abourjeili, Joseph E Nassar, Fadi Bitar, Mariam Arabi
Since its emergence, the COVID-19 pandemic had a dramatic impact on the public health worldwide and it scarred the medical, economical, and social determinants of health. Even after the significant vaccination advances, the disease of SARS-CoV-2 can manifest in severe presentations with life-threatening thromboembolic and multi-organ complications leading to notable morbidity and mortality. Clinicians and researchers are on continuous pursuit of investigating different approaches in the attempt to prevent the infection and minimize its severity...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37000457/sharps-injuries-with-lovenox-and-generic-enoxaparin-prefilled-safety-syringes-a-12-year-retrospective-cross-sectional-analytical-study
#9
JOURNAL ARTICLE
Terry Grimmond, MaryAnn Gruden, Bobbi Jo Hurst, Lydia F Crutchfield
PURPOSE: Investigate the incidence and mechanisms of sharps injuries (SI) to staff using Lovenox and generic enoxaparin prefilled syringes. METHODS: Four national adverse event databases were examined over a 12-year period for incidence and brands involved with injury events to staff using enoxaparin prefilled syringes. RESULTS: The search revealed 581 adverse events (including 20 sharps injuries) associated with device malfunction in 8 of 16 brands, with one brand mentioned significantly more frequently than others...
March 31, 2023: Nursing
https://read.qxmd.com/read/36732301/comparing-venous-thromboembolism-prophylactic-agents-after-hip-fracture-surgery-a-national-database-study
#10
JOURNAL ARTICLE
Peter Y Joo, Maxwell Modrak, Nancy Park, Jordan Brand, Lee E Rubin, Jonathan N Grauer, Jenna A Bernstein
INTRODUCTION: Although the use of venous thromboembolism (VTE) chemoprophylaxis has markedly reduced VTE rates after hip fracture surgery, few studies have directly compared the efficacy of different anticoagulant agents in this setting. The purpose of this study was to compare outcomes of Lovenox, Eliquis, or Coumadin as VTE prophylaxis after hip fracture surgery. METHODS: The PearlDiver MHip national database was queried for patients older than 60 years undergoing first-time hip fracture surgery with no concurrent pelvic or distal femoral fractures...
December 1, 2022: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
https://read.qxmd.com/read/35867417/comparison-table-some-parenteral-anticoagulants-for-vte
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 25, 2022: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/35867416/drugs-for-treatment-and-prevention-of-venous-thromboembolism
#12
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 25, 2022: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/35647566/modulation-of-interleukin-6-and-its-effect-on-late-vein-wall-injury-in-a-stasis-mouse-model-of-deep-vein-thrombosis
#13
JOURNAL ARTICLE
Abigail R Dowling, Catherine E Luke, Qing Cai, Antonio M Pellerito, Andrea T Obi, Peter K Henke
Objective: Deep vein thrombosis (DVT) and its sequela, post-thrombotic syndrome (PTS), remain a clinically significant problem. Interleukin-6 (IL-6) is a proinflammatory cytokine that is elevated in patients who develop PTS. We hypothesized that genetic deletion of IL-6 and the use of anti-IL-6 pharmacologic agents would be associated with decreased late vein wall injury. Methods: Wild-type C57BL/6J (WT) and IL-6-/- mice underwent induction of stasis venous thrombosis by ligation of the infrarenal IVC...
2022: Journal of vascular surgery. Vascular science
https://read.qxmd.com/read/35530828/a-retrospective-comparative-cohort-study-of-craniotomy-and-prophylactic-enoxaparin-timing
#14
JOURNAL ARTICLE
David R Hallan, Bao Sciscent, Elias Rizk
INTRODUCTION:  Post-operative venous thromboembolism (VTE) prophylaxis is the standard of care after craniotomy, but there is debate over when to initiate VTE prophylaxis to decrease the morbidity and mortality experienced by these patients. This study aims to determine the effects of starting enoxaparin on day one vs. day three after craniotomy. METHODS: We used a multi-institutional health research network (TriNetX) to gather data from the electronic medical records of patients who started enoxaparin one day after craniotomy (cohort 1) and patients who started it three days later (cohort 2)...
April 2022: Curēus
https://read.qxmd.com/read/34587526/pregnancy-after-iliac-vein-stenting-for-pelvic-venous-insufficiency
#15
MULTICENTER STUDY
Peter J Pappas, Gaurav Lakhanpal, Theresa Soto, Zoe Deol, Richard Kennedy, Sanjiv Lakhanpal
BACKGROUND: The use of iliac vein stenting for the treatment of pelvic pain secondary to pelvic venous insufficiency has significantly increased. In women of childbearing age, the effect of the gravid uterus on stent function and patency is unclear. The purpose of this investigation was to determine the effect of pregnancy on stent patency and reintervention rate in women with iliac vein stents. METHODS: A retrospective chart review and email survey was performed to identify women treated at the Center for Vascular Medicine who were treated with iliac vein stenting and who had subsequent pregnancies...
March 2022: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://read.qxmd.com/read/34513429/portal-vein-thrombosis-and-splenic-infarction-in-a-covid-19-patient
#16
Abdul Rehman, Anoop Jose Thoppil, Sara L Wallach
COVID-19 is a novel viral infection that primarily affects the lungs and runs the gamut from a mild, self-limiting, febrile illness to respiratory failure and death. It manifested as a global pandemic in 2020 and has since claimed millions of lives. Only a few months into this pandemic, it became evident that the viral infection leads to a hypercoagulable state. Anticoagulants became a standard and important part of therapy while d-dimer became a useful test to guide the choice of the anticoagulant (therapeutic vs prophylactic Lovenox)...
August 2021: Curēus
https://read.qxmd.com/read/34420414/lemierre-syndrome-in-a-patient-with-splenectomy-secondary-to-pyruvate-kinase-deficiency-complicated-by-heparin-resistance
#17
JOURNAL ARTICLE
Kiley Clark, Morgan Sly, Pearl Chan, Hobart Lai, Hadi Ali, David Contreras, Ramanjeet Sidhu, Janpreet Bhandohal, Sikha Mishra, Rasha Kuran, Rahul Dev Polineni
Lemierre syndrome was first documented in the literature in 1936, and is defined as septic thrombophlebitis of the internal jugular vein. It is typically a result of oropharyngeal infection causing local soft tissue inflammation, which spreads to vasculature, and promotes formation of septic thrombi within the lumen, persistent bacteremia, and septic emboli. We present the case of a 24-year-old incarcerated man, who presented with leukocytosis and a right-sided tender, swollen neck after undergoing left mandibular molar extraction for an infected tooth...
January 2021: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/34078133/safety-and-efficacy-of-prophylactic-enoxaparin-adjusted-by-anti-factor-xa-peak-levels-in-pancreatic-surgery
#18
JOURNAL ARTICLE
Katherine Kramme, Paya Sarraf, Saad Shebrain, Gitonga Munene
BACKGROUND: Recommended prophylactic doses of enoxaparin (Lovenox) are associated with subprophylactic anti-Factor Xa (anti-Xa) levels. This study examines the safety and efficacy of anti-Xa-guided dosing of enoxaparin in pancreatic surgery. METHODS: Prospectively enrolled patients undergoing pancreatic surgery received enoxaparin dosing adjusted based on peak anti-Xa levels and were compared to a historical cohort of patients. RESULTS: Baseline characteristics were similar between the intervention and control groups...
June 2, 2021: American Surgeon
https://read.qxmd.com/read/33880136/fatal-retroperitoneal-hematoma-associated-with-covid-19-prophylactic-anticoagulation-protocol
#19
Michael Teta, Michael J Drabkin
Due to the association between Covid-19 and thromboembolic events, there has been a surge in anticoagulation use during the pandemic based on evolving guidelines for management of hospitalized Covid-19 patients. Spontaneous soft tissue hematoma can be a severe complication of anticoagulation. Herein we present a fatal case of severe spontaneous soft tissue hematoma secondary to anticoagulant therapy in a 67kg 81-year-old female with chronic kidney disease who was admitted to the hospital with Covid-19 pneumonia...
July 2021: Radiology Case Reports
https://read.qxmd.com/read/33489568/rectus-sheath-hematoma-a-rare-surgical-emergency
#20
Kyle Drinnon, Sean S Simpson, Yana Puckett, Catherine A Ronaghan, Robyn E Richmond
A rectus sheath hematoma (RSH) is a rare medical condition that consists of blood accumulating in the rectus abdominis muscle sheath. RSH is most frequently due to a hemorrhage from the superior or inferior epigastric artery. RSH has many specific risk factors, such as anticoagulant use. As the use of anticoagulants increases, the incidence of RSH has also increased. This condition can present with the infrequent complication of abdominal compartment syndrome (ACS), which can require surgical decompression of the abdomen to avoid high morbidity and mortality...
December 18, 2020: Curēus
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