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https://www.readbyqxmd.com/read/27826330/management-of-patients-with-long-qt-syndrome
#1
REVIEW
Yongkeun Cho
Long QT syndrome (LQTS) is a rare cardiac channelopathy associated with syncope and sudden death due to torsades de pointes and ventricular fibrillation. Syncope and sudden death are frequently associated with physical and emotional stress. Management of patients with LQTS consists of life-style modification, β-blockers, left cardiac sympathetic denervation (LCSD), and implantable cardioverter-defibrillator (ICD) implantation. Prohibition of competitive exercise and avoidance of QT-prolonging drugs are important issues in life-style modification...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27761156/left-cardiac-sympathetic-denervation-an-important-treatment-option-for-patients-with-hereditary-ventricular-arrhythmias
#2
Yongkeun Cho
Medications such as ß-blockers are currently the primary treatment for patients with hereditary arrhythmia syndromes such as long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). However, these drugs are ineffective in some patients, and the other treatment option, that is implantable cardioverter defibrillator (ICD) implantation, is associated with significant complications in young and active patients. Left cardiac sympathetic denervation (LCSD) may reduce the wide gap between life-long ß-blocker medication and ICD implantation...
October 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27451284/the-jervell-and-lange-nielsen-syndrome-atrial-pacing-combined-with-%C3%A3-blocker-therapy-a-favourable-approach-in-young-high-risk-patients-with-long-qt-syndrome
#3
Andreas Früh, Geir Siem, Henrik Holmström, Gaute Døhlen, Kristina H Haugaa
BACKGROUND: Patients with Jervell and Lange-Nielsen syndrome (JLNS) exhibit severe phenotypes that are characterized by congenital deafness, very long QT-intervals and a high risk of life-threatening arrhythmias. Current treatment strategies include high doses of ß-blocker medication, left cardiac sympathetic denervation (LCSD), and ICD implantation which is challenging in young children. Objective The purpose of this study was to evaluate the safety and effect of pacing in addition to ß-blocker treatment in children with JLNS...
July 20, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26887900/effect-of-left-cardiac-sympathetic-denervation-on-the-electromechanical-window-in-patients-with-either-type-1-or-type-2-long-qt-syndrome-a-pilot-study
#4
Andrew E Schneider, J Martijn Bos, Michael J Ackerman
BACKGROUND: Left cardiac sympathetic denervation (LCSD) exerts significant antifibrillatory effects in patients with long QT syndrome (LQTS). Recently, electromechanical window (EMW) has emerged as a novel torsadogenic marker in LQTS, superior to QT interval (QTc) in distinguishing symptomatic from asymptomatic patients. OBJECTIVE: To explore the hypothesis that LCSD improves EMW most favorably in patients with LQT1. DESIGN: From September 2006 to July 2015, 44 LQT1 and 25 LQT2 patients underwent LCSD...
February 17, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/26625541/left-cardiac-sympathetic-denervation-in-patients-with-casq2-associated-catecholaminergic-polymorphic-ventricular-tachycardia
#5
Ibrahim Marai, Monther Boulos, Asaad Khoury
BACKGROUND: Left cardiac sympathetic denervation (LCSD) was reported to be effective in patients with intractable ryanodine receptor mutation-associated catecholaminergic polymorphic ventricular tachycardia (CPVT). OBJECTIVES: To report our experience with LCSD in calsequestrin (CASQ2) mutation-associated CPVT. METHODS: LCSD was performed in three patients with CASQ2 mutation-associated CPVT with symptoms and exercise-induced ventricular arrhythmia despite high dose beta-blocker RESULTS: None of them experienced symptoms or exercise-induced ventricular arrhythmia after LCSD...
September 2015: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/26341607/quality-of-life-after-videoscopic-left-cardiac-sympathetic-denervation-in-patients-with-potentially-life-threatening-cardiac-channelopathies-cardiomyopathies
#6
Ryan M Antiel, J Martijn Bos, Daniel D Joyce, Heidi J Owen, Penny L Roskos, Christopher Moir, Michael J Ackerman
BACKGROUND: Left cardiac sympathetic denervation (LCSD) provides an additive or potentially alternative treatment option for patients with life-threatening cardiac channelopathies/cardiomyopathies. OBJECTIVE: We sought to examine the effects of LCSD on quality of life (QOL). METHODS: From November 2005 to May 2013, 109 patients who underwent LCSD were subsequently sent postoperative QOL surveys. RESULTS: Of 109 patients, 8 (7%) could not be contacted...
January 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/26304528/device-therapy-in-the-setting-of-long-qt-syndrome
#7
REVIEW
Troy Rhodes, Raul Weiss
Congenital long QT syndrome (LQTS) is an inherited disorder of myocardial repolarization characterized by prolongation of the QT interval associated with life-threatening polymorphic ventricular tachycardia. The treatment of congenital LQTS involves antiadrenergic therapies: β-blockers and surgical left cardiac sympathetic denervation (LCSD) to decrease sympathetic input to the heart, cardiac pacing, and implantable cardioverter-defibrillator (ICDs). Although this article focuses on the role of device therapy for the treatment of LQTS, it also discusses the role of β-blockers and LCSD because they are concomitant with device therapy...
September 2015: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/26078933/thoracoscopic-left-cardiac-sympathetic-denervation-for-a-patient-with-catecholaminergic-polymorphic-ventricular-tachycardia-and-recurrent-implantable-cardioverter-defibrillator-shocks
#8
Woo-Sik Yu, Tae-Hoon Kim, Jee Won Suh, Seunghwan Song, Chang Young Lee, Boyoung Joung
A patient presented with loss of consciousness and conversion. During an exercise test, catecholaminergic polymorphic ventricular tachycardia (CPVT) resulted in cardiac arrest. He started taking medication (a beta-blocker and flecainide) and an implantable cardioverter defibrillator (ICD) was inserted, but the ventricular tachycardia did not resolve. Left cardiac sympathetic denervation (LCSD) was then performed under general anesthesia, and the patient was discharged on the second postoperative day without complications...
June 2015: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26019152/clinical-management-of-catecholaminergic-polymorphic-ventricular-tachycardia-the-role-of-left-cardiac-sympathetic-denervation
#9
MULTICENTER STUDY
Gaetano M De Ferrari, Veronica Dusi, Carla Spazzolini, J Martijn Bos, Dominic J Abrams, Charles I Berul, Lia Crotti, Andrew M Davis, Michael Eldar, Maria Kharlap, Asaad Khoury, Andrew D Krahn, Antoine Leenhardt, Christopher R Moir, Attilio Odero, Louise Olde Nordkamp, Thomas Paul, Ferran Rosés I Noguer, Maria Shkolnikova, Jan Till, Arthur A M Wilde, Michael J Ackerman, Peter J Schwartz
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder causing life-threatening arrhythmias whenever sympathetic activity increases. β-Βlockers are the mainstay of therapy; when they fail, implantable cardioverter-defibrillators (ICDs) are used but often cause multiple shocks. Preliminary results with flecainide appear encouraging. We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evidence remains anecdotal...
June 23, 2015: Circulation
https://www.readbyqxmd.com/read/25576780/automated-external-defibrillator-rescues-among-children-with-diagnosed-and-treated-long-qt-syndrome
#10
Kavitha N Pundi, J Martijn Bos, Bryan C Cannon, Michael J Ackerman
BACKGROUND: Long QT syndrome (LQTS) is a potentially lethal yet highly treatable cardiac channelopathy. A comprehensive LQTS-directed treatment program often includes an automated external defibrillator (AED). OBJECTIVE: The purpose of this study was to determine the incidence of AED rescues among children evaluated, risk-stratified, and treated in an LQTS specialty center. METHODS: We performed a retrospective review of the electronic medical records to identify 1665 patients evaluated in our Genetic Heart Rhythm Clinic (1999-2013)...
April 2015: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/25559122/effects-on-repolarization-using-dynamic-qt-interval-monitoring-in-long-qt-patients-following-left-cardiac-sympathetic-denervation
#11
Christopher V Desimone, J Martijn Bos, Katy M Bos, Jackson J Liang, Nikhil A Patel, David O Hodge, Amit Noheria, Samuel J Asirvatham, Michael J Ackerman
BACKGROUND: Videoscopic left cardiac sympathetic denervation (LCSD) is an adjunct therapy for reduction of arrhythmia-induced events in patients with long-QT syndrome (LQTS). LCSD reduces LQTS-triggered breakthrough cardiac events. The temporal effects of QTc changes post-LCSD have not been studied. METHODS: We utilized continuous QTc monitoring on 72 patients with LQTS. We evaluated acute and long-term QTc changes in comparison to 12-lead ECG-derived QTc values prior to surgery, 24 hours postsurgery, and at follow up ≥3 months...
April 2015: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/24614115/cardiac-sympathetic-denervation-to-prevent-life-threatening-arrhythmias
#12
REVIEW
Peter J Schwartz
Experimental and clinical evidence indicating an antiarrhythmic effect of cardiac sympathetic denervation has been available for 100 years. Experimental data show that left cardiac sympathetic denervation (LCSD), in particular, is not only antiarrhythmic, but also antifibrillatory-an effect exquisitely important for any clinical condition associated with a high risk of ventricular fibrillation and sudden cardiac death. LCSD has additional effects on both the coronary circulation and the mechanical performance of the left ventricle, with important implications for patients with ischaemic cardiomyopathy...
June 2014: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/24522951/left-cardiac-sympathetic-denervation-in-the-netherlands-for-the-treatment-of-inherited-arrhythmia-syndromes
#13
L R A Olde Nordkamp, A H G Driessen, A Odero, N A Blom, D R Koolbergen, P J Schwartz, A A M Wilde
INTRODUCTION: Treating therapy-resistant patients with inherited arrhythmia syndromes can be difficult and left cardiac sympathetic denervation (LCSD) might be a viable alternative treatment option. We provide an overview of the indications and outcomes of LCSD in patients with inherited arrhythmia syndromes in the only tertiary referral centre in the Netherlands where LCSD is conducted in these patients. METHODS: This was a retrospective study, including all patients with inherited arrhythmia syndromes who underwent LCSD in our institution between 2005 and 2013...
April 2014: Netherlands Heart Journal
https://www.readbyqxmd.com/read/24482077/left-cardiac-sympathetic-denervation-in-patients-with-heart-failure-a-new-indication-for-an-old-intervention
#14
REVIEW
Gaetano M De Ferrari, Peter J Schwartz
Heart failure (HF) is characterized by an autonomic imbalance with withdrawal of vagal activity and increased sympathetic activity. Novel non-pharmacological approaches to HF aimed at increasing vagal activity are being proposed. Left cardiac sympathetic denervation (LCSD) has been shown to modify favorably the outcome of several disorders characterized by life-threatening arrhythmias triggered by increased sympathetic activity. The present manuscript discusses the rationale and the limited experimental and clinical experience suggesting a potential role for LCSD in the treatment of patients with advanced heart failure...
April 2014: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/23976950/noise-exposure-and-hearing-impairment-among-chinese-restaurant-workers-and-entertainment-employees-in-hong-kong
#15
Xiang Qian Lao, Ignatius Tak Sun Yu, Dennis Kin Kwok Au, Yuk Lan Chiu, Claudie Chiu Yi Wong, Tze Wai Wong
BACKGROUND: Noise-induced hearing loss (NIHL) is a major concern in the non-manufacturing industries. This study aimed to investigate the occupational noise exposure and the NIHL among Chinese restaurant workers and entertainment employees working in the service industry in Hong Kong. METHODS: This cross-sectional survey involved a total of 1,670 participants. Among them, 937 were randomly selected from the workers of Chinese restaurants and 733 were selected from workers in three entertainment sectors: radio and television stations; cultural performance halls or auditoria of the Leisure and Cultural Services Department (LCSD); and karaoke bars...
2013: PloS One
https://www.readbyqxmd.com/read/23728945/left-cardiac-sympathetic-denervation-in-long-qt-syndrome-analysis-of-therapeutic-nonresponders
#16
J Martijn Bos, Katy M Bos, Jonathan N Johnson, Christopher Moir, Michael J Ackerman
BACKGROUND: Long QT syndrome (LQTS) is a potentially lethal but highly treatable cardiac channelopathy. Treatment options include pharmacotherapy, device therapy, and left cardiac sympathetic denervation (LCSD). Here, we sought to determine the characteristics of LQTS patients who have had ≥1 LQTS-related breakthrough cardiac event (BCE) after LCSD. METHODS AND RESULTS: We performed retrospective chart review for 52 consecutive patients (24 males; mean age at diagnosis, 10...
August 2013: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/23580847/presentation-diagnosis-and-management-of-limbal-stem-cell-deficiency
#17
REVIEW
Kunjal Sejpal, Pejman Bakhtiari, Sophie X Deng
The human corneal surface epithelium is continuously repopulated by the limbal stem cells (LSCs). Limbal Stem Cell Deficiency (LSCD) can lead to corneal opacity and vascularization, with consequent visual impairment or blindness. Many acquired and congenital diseases can lead to LCSD by direct injury to the LSCs, destruction of LSC niche, or both. Based on the severity of the disease, LSCD can present with various symptoms and signs. Although LSCD can be detected clinically, laboratory tests are necessary to confirm the diagnosis and monitor the disease progression...
January 2013: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/23099357/left-cardiac-sympathetic-denervation-for-treatment-of-symptomatic-systolic-heart-failure-patients-a-pilot-study
#18
RANDOMIZED CONTROLLED TRIAL
Germano Emílio Conceição-Souza, Paulo Manuel Pêgo-Fernandes, Fatima das Dores Cruz, Guilherme Veiga Guimarães, Fernando Bacal, Marcelo Luiz Campos Vieira, Cesar José Grupi, Maria Clementina Pinto Giorgi, Fernanda Marciano Consolim-Colombo, Carlos Eduardo Negrão, Maria Urbana P Rondon, Luiz Felipe Pinho Moreira, Edimar Alcides Bocchi
AIMS: To evaluate the feasibility, safety, and potential beneficial effects of left cardiac sympathetic denervation (LCSD) in systolic heart failure (HF) patients. METHODS AND RESULTS: In this prospective, randomized pilot study, inclusion criteria were New York Heart Association (NYHA) functional class II or III, left ventricular ejection fraction (LVEF) ≤40%, sinus rhythm, and resting heart rate >65 b.p.m., despite optimal medical therapy (MT). Fifteen patients were randomly assigned either to MT alone or MT plus LCSD...
December 2012: European Journal of Heart Failure
https://www.readbyqxmd.com/read/22821214/left-cardiac-sympathetic-denervation-for-the-management-of-life-threatening-ventricular-tachyarrhythmias-in-young-patients-with-catecholaminergic-polymorphic-ventricular-tachycardia-and-long-qt-syndrome
#19
Heike E Schneider, Michael Steinmetz, Ulrich Krause, Thomas Kriebel, Wolfgang Ruschewski, Thomas Paul
BACKGROUND: Left cardiac sympathetic denervation (LCSD) may be a therapeutic adjunct for young patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) and long QT syndrome (LQTS) who are not fully protected by beta-blockade. OBJECTIVE: The objective of this analysis was to report our institutional experience with LSCD in young patients for the management of life-threatening ventricular arrhythmias in CPVT and LQTS. METHODS: Ten young patients with CPVT and LQTS underwent transaxillary LSCD at our institution...
January 2013: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/22787014/videoscopic-left-cardiac-sympathetic-denervation-for-patients-with-recurrent-ventricular-fibrillation-malignant-ventricular-arrhythmia-syndromes-besides-congenital-long-qt-syndrome
#20
Mira A Coleman, J Martijn Bos, Jonathan N Johnson, Heidi J Owen, Claude Deschamps, Christopher Moir, Michael J Ackerman
BACKGROUND: Treatment options for patients with recurrent ventricular arrhythmias refractory to pharmacotherapy and ablation are minimal. Although left cardiac sympathetic denervation (LCSD) is well established in long-QT syndrome, its role in non-long-QT syndrome arrhythmogenic channelopathies and cardiomyopathies is less clear. Here, we report our single-center experience in performing LCSD in this setting. METHODS AND RESULTS: In this institutional review board-approved study, we retrospectively reviewed the electronic medical records of all patients (N=91) who had videoscopic LCSD at our institution from 2005 to 2011...
August 1, 2012: Circulation. Arrhythmia and Electrophysiology
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