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Pediatric infectious disease

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https://www.readbyqxmd.com/read/29149980/incidence-of-infectious-complications-in-children-with-acute-lymphoblastic-leukemia-treated-with-hematopoietic-stem-cell-transplantation
#1
A Zaucha-Prażmo, J R Kowalczyk, K Drabko, K Czyżewski, J Goździk, O Zając-Spychała, J Wachowiak, J Frączkiewicz, E Gorczyńska, K Kałwak, J Styczyński
OBJECTIVE: We analyzed incidence and profile of infections in children with acute lymphoblastic leukemia (ALL) treated with hematopoietic stem cell transplantation (HSCT) in Polish pediatric HSCT departments, over a 2-year period. PATIENTS AND METHODS: Hospital records of 67 patients, who underwent allogeneic HSCT for ALL, were analyzed retrospectively for microbiologically documented infection: bacterial infection (BI), viral infection (VI), and fungal infection (FI)...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29138738/spatial-distribution-and-trends-of-waterborne-diseases-in-tashkent-province
#2
Veluswami Saravanan Subramanian, Min Jung Cho, Siwei Zoe Tan, Dilorom Fayzieva, Christian Sebaly
Introduction: The cumulative effect of limited investment in public water systems, inadequate public health infrastructure, and gaps in infectious disease prevention increased the incidence of waterborne diseases in Uzbekistan. The objectives of this study were: (1) to spatially analyze the distribution of the diseases in Tashkent Province, (2) to identify the intensity of spatial trends in the province, (3) to identify urban-rural characteristics of the disease distribution, and (4) to identify the differences in disease incidence between pediatric and adult populations of the province...
2017: Central Asian Journal of Global Health
https://www.readbyqxmd.com/read/29135900/ondansetron-prescription-for-home-use-in-a-pediatric-emergency-department
#3
James M Gray, Jaya D Maewal, Scott A Lunos, Ronald A Furnival, Marissa A Hendrickson
OBJECTIVES: Ondansetron has been shown to decrease admission rates and the need for intravenous fluids among pediatric emergency department (ED) patients with acute gastroenteritis, but there is limited evidence regarding its use after ED discharge. This study describes prescribing patterns for ondansetron and assesses the effects of ondansetron home prescription on rate of return. METHODS: Data were gathered from the electronic health record on 2 separate but overlapping groups of patients seen in a pediatric ED from 2012 to 2014...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29131924/when-an-orbital-infection-isn-t-infectious-at-all-a-review-of-orbital-inflammatory-syndrome
#4
Sadie A LaPonsie, Peter K Rabiah
Orbital inflammatory syndrome (OIS) includes a wide range of clinical manifestations and may initially be misdiagnosed as orbital cellulitis due similar symptoms of fever, periorbital swelling, and pain with eye movements. A diagnosis of OIS requires evaluation for underlying systemic disorders including autoimmune disorders and thyroid disease. Symptoms typically improve rapidly after initiation of steroid therapy, although recurrence can occur. This article presents an illustrative case of a 13-year-old girl with OIS...
November 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29129626/clinical-significance-of-the-serum-biomarker-index-detection-in-children-with-henoch-schonlein-purpura
#5
Narangerel Purevdorj, Yun Mu, Yajun Gu, Fang Zheng, Ran Wang, Jinwei Yu, Xuguo Sun
OBJECTIVE: To explore a panel of serum biomarkers for laboratory diagnosis of pediatric Henoch-Schönlein purpura (HSP). METHODS: The blood white blood cells (WBC) and serum levels of serum amyloid A (SAA), interleukin 6 (IL-6), immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin E (IgE), C-reactive protein (CRP), complement component 3 (C3), complement component 4 (C4), and ASO (anti-streptolysin O) were detected in 127 patients with Henoch-Schonlein purpura (HSP), 110 cases of septicemia patients, and 121 healthy volunteers...
November 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29126502/clinical-presentation-of-crohn-s-ulcerative-colitis-and-indeterminate-colitis-symptoms-extraintestinal-manifestations-and-disease-phenotypes
#6
Yangyang R Yu, J Ruben Rodriguez
The incidence of inflammatory bowel disease (IBD) is rising with 25% of IBD diagnosed in children under 18 years of age. The clinical presentation of IBD in children is often vague leading to initial misdiagnosis as infectious colitis or irritable bowel syndrome. When IBD is identified, overlap in histologic and endoscopic features may lead to difficulty distinguishing Crohn's disease from ulcerative colitis, resulting in a higher frequency of the diagnosis indeterminate colitis or IBD unspecified. Recognizing the common and the atypical presentation of pediatric IBD and extraintestinal manifestations will aid in expeditious referral and early diagnosis...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29111083/postoperative-outcomes-in-vedolizumab-treated-pediatric-patients-undergoing-abdominal-operations-for-inflammatory-bowel-disease
#7
Amy L Lightner, Chung Sang Tse, D Dean Potter, Christopher Moir
INTRODUCTION: Recent studies have found vedolizumab to be an independent predictor of increased rates of postoperative complications and surgical site infections (SSIs) in adults with inflammatory bowel disease (IBD), but studies in the pediatric surgical population are lacking. We sought to determine the 30-day postoperative infectious complication rate among pediatric IBD patients who received vedolizumab within 12weeks of a major abdominal operation. METHODS: A retrospective chart review was performed on pediatric IBD patients who underwent an abdominal operation between 5/20/2014 and 6/1/2017...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29107545/infectious-complications-of-ventricular-assist-device-use-in-children-in-the-united-states-data-from-the-pediatric-interagency-registry-for-mechanical-circulatory-support-pedimacs
#8
Scott R Auerbach, Marc E Richmond, Kurt R Schumacher, Dalia Lopez-Colon, Max B Mitchell, Mark W Turrentine, Ryan S Cantor, Robert A Niebler, Pirooz Eghtesady
BACKGROUND: Infections are frequent in pediatric ventricular assist device (VAD) patients. In this study we aimed to describe infections in durable VAD patients reported to Pedimacs. METHODS: Durable VAD data from the Pedimacs registry (September 19, 2012 to December 31, 2015) were analyzed. Infections were described with standard descriptive statistics, Kaplan-Meier analysis and competing outcomes analysis. RESULTS: There were 248 implants in 222 patients, with a mean age and a median follow-up of 11 ± 6...
October 3, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29099362/oral-manifestations-of-systemic-disease
#9
Heidi L Gaddey
On examination, the oral cavity may exhibit manifestations of underlying systemic disease and serve as an indicator of overall health. Systemic diseases with oral findings include autoimmune, hematologic, endocrine, and neoplastic processes. Autoimmune disease may manifest as oral ulcerations, changes in the salivary and parotid glands, and changes in the tongue. Patients with hematologic illnesses may present with gingival bleeding or tongue changes such as glossitis, depending on the etiology. Oral changes associated with endocrine illness are variable and depend on the underlying condition...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29062489/staphylococcus-aureus-interaction-with-pseudomonas-aeruginosa-biofilm-enhances-tobramycin-resistance
#10
T Beaudoin, Y C W Yau, P J Stapleton, Y Gong, P W Wang, D S Guttman, V Waters
Antimicrobial resistance is a significant threat to the treatment of infectious disease. Multiple mechanisms of resistance to different classes of antibiotics have been identified and well-studied. However, these mechanisms are studied with bacteria in isolation, whereas often, infections have a polymicrobial basis. Using a biofilm slide chamber model, we visualized the formation and development of clinical Pseudomonas aeruginosa biofilms in the presence of secreted Staphylococcus aureus exoproducts, two bacteria that commonly co-infect pediatric patients with cystic fibrosis...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29061869/infection-prevention-and-control-in-pediatric-ambulatory-settings
#11
REVIEW
Mobeen H Rathore, Mary Anne Jackson
Since the American Academy of Pediatrics published its statement titled "Infection Prevention and Control in Pediatric Ambulatory Settings" in 2007, there have been significant changes that prompted this updated statement. Infection prevention and control is an integral part of pediatric practice in ambulatory medical settings as well as in hospitals. Infection prevention and control practices should begin at the time the ambulatory visit is scheduled. All health care personnel should be educated regarding the routes of transmission and techniques used to prevent the transmission of infectious agents...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29061192/an-unusual-complication-of-the-traditional-treatment-of-a-closed-fracture-generalized-tetanus-a-case-report
#12
Landry W Tchuenkam, Emmanuel K Ndame, Marc L Guifo, Celestin Danwang, Ginette C Kalla, Arthur Essomba
BACKGROUND: Tetanus is a severe infectious disease that can lead to death. The clinical manifestations are due to an exotoxin secreted by Clostridium tetani, a spore-producing Gram-positive bacillus. The penetration of the germ is made through a skin opening, independently of the size of the wound. CASE PRESENTATION: A 13-year-old black African boy of the Bantu ethnic group with unknown tetanus vaccination status presented to our pediatric emergency room for the management of chest and vertebral pains which started a few days after traditional treatment by scarification and herbal and leaf ointment...
October 24, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29055023/using-physician-level-emergency-department-utilization-reports-to-address-avoidable-visits-by-patients-managed-by-pediatric-specialists
#13
Jarone Lee, Esther Israel, Howard Weinstein, T Bernard Kinane, Mark Pasternack, Pamela Linov, Haytham M A Kaafarani, Peter Greenspan, Sandhya K Rao
OBJECTIVES: Emergency department (ED) utilization is a major driver of cost. Specialist physicians have an important role in addressing ED utilization, especially at tertiary medical centers that treat highly specialized patients. We analyzed if reporting of ED utilization to pediatric specialist physicians can decrease ED visits. METHODS: Physicians within pediatric neurology, hematology and oncology, infectious diseases, and pulmonary divisions received their ED use reports...
October 20, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29036392/update-from-the-advisory-committee-on-immunization-practices
#14
Sean T O'Leary, David W Kimberlin
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Representatives from the American Academy of Pediatrics (Carrie L...
September 25, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29035316/non-traditional-risk-factors-of-albuminuria-in-the-pediatric-population-a-scoping-review
#15
REVIEW
Erick Sierra-Diaz, Alfredo de Jesus Celis-de la Rosa, Felipe Lozano-Kasten, Alejandro Bravo-Cuellar, Mariana Garcia-Gutierrez, Hernandez-Flores Georgina
The presence of albumin in urine has been used for more than four decades as a marker of renal and cardiovascular damage. Most of the information on this marker is related to adults. The prevalence of albuminuria in the pediatric population has been reported as being 2.2-12.8% in some countries. Most research in this field is related to albuminuria and diseases, such as diabetes and hypertension. Using the methodology described by Arksey and O'Malley in 2005, a scoping review was carried out to show that the presence of albumin in urine in the pediatric population might be associated with environmental, demographic, congenital, infectious, and non-infectious factors...
October 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29023356/point-of-care-testing-in-pediatric-infectious-diseases
#16
Kristina Keitel, Laurence Lacroix, Alain Gervaix
No abstract text is available yet for this article.
October 7, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29021105/invasive-pneumococcal-pneumonia-caused-by-13-valent-pneumococcal-conjugate-vaccine-types-in-children-with-different-schedules
#17
Hong-Yi Lee, Yu-Chia Hsieh, Ching-Chuan Liu, Yi-Chuan Huang, Kuang-Yi Chang, Hsin Chi, Luan-Yin Chang, Yhu-Chering Huang, Li-Min Huang
BACKGROUND: In Taiwan, the age group with the greatest incidence of invasive pneumococcal disease is 2-5 years of age, which is different from other countries. This study was conducted to identify risk factors and different 13-valent pneumococcal conjugate vaccine (PCV13) schedules associated with vaccine-type invasive pneumococcal pneumonia (IPP) despite prior vaccination. METHODS: A case-control study was conducted prospectively between August 2012 and December 2015 at five participating medical centers...
September 27, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29020143/anti-infective-acquisition-costs-for-a-stewardship-program-getting-to-the-bottom-line
#18
Sarah K Parker, Amanda L Hurst, Cary Thurm, Matthew Millard, Timothy C Jenkins, Jason Child, Casey Dugan
Background: Though antimicrobial stewardship programs (ASPs) are in place for patient safety, financial justification is often required. In 2016, the Infectious Diseases Society of America (IDSA) recommended that anti-infective costs be measured by patient-level administration data normalized for patient census. Few publications use this methodology. Here, we aim to compare 3 methods of drug cost analysis during 3 phases of an ASP as an example of this recommendation's implementation...
July 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019745/imaging-of-nonmalignant-adrenal-lesions-in-children
#19
Kiran M Sargar, Geetika Khanna, Rebecca Hulett Bowling
The adrenal glands in children can be affected by a variety of benign lesions. The diagnosis of adrenal lesions can be challenging, but assessment of morphologic changes in correlation with the clinical presentation can lead to an accurate diagnosis. These lesions can be classified by their cause: congenital (eg, discoid adrenal gland, horseshoe adrenal gland, and epithelial cysts), vascular and/or traumatic (eg, adrenal hemorrhage), infectious (eg, granulomatous diseases), enzyme deficiency disorders (eg, congenital adrenal hyperplasia [CAH] and Wolman disease), benign neoplasms (eg, pheochromocytomas, ganglioneuromas, adrenal adenomas, and myelolipomas), and adrenal mass mimics (eg, extralobar sequestration and extramedullary hematopoiesis)...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29018323/cerebrospinal-fluid-amino-acid-profiling-of-pediatric-cases-with-tuberculous-meningitis
#20
Shayne Mason, Carolus J Reinecke, Regan Solomons
Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of tuberculous meningitis (TBM) being the most severe manifestation. TBM is often difficult to diagnose in its early stages because of its non-specific clinical presentation. Of particular concern is that late diagnosis, and subsequent delayed treatment, leads to high risk of long-term neurological sequelae, and even death...
2017: Frontiers in Neuroscience
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