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sympathetic denervation

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https://www.readbyqxmd.com/read/29780124/hiv-dementia-with-a-decreased-cardiac-123-i-metaiodobenzylguanidine-uptake-masquerading-as-dementia-with-lewy-bodies
#1
Masanori Kurihara, Takuya Sasaki, Hiroyuki Ishiura, Shoji Tsuji
Cardiac 123 I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon emission computed tomography reduced the possibility of comorbid Lewy body pathology causing the patient' s parkinsonism. The decreased MIBG uptake was most likely due to postganglionic sympathetic nerve denervation, which can also be caused by HIV...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29772927/design-and-simulation-of-novel-laparoscopic-renal-denervation-system-a-feasibility-study
#2
Eunbi Ye, Jinhwan Baik, Seunghyun Lee, Seon Young Ryu, Sunchoel Yang, Eue-Keun Choi, Won Hoon Song, Hyeong Dong Yuk, Chang Wook Jeong, Sung-Min Park
PURPOSE: In this study, we propose a novel laparoscopy-based renal denervation (RDN) system for treating patients with resistant hypertension. In this feasibility study, we investigated whether our proposed surgical instrument can ablate renal nerves from outside of the renal artery safely and effectively and can overcome the depth-related limitations of the previous catheter-based system with less damage to the arterial walls. METHOD: We designed a looped bipolar electrosurgical instrument to be used with laparoscopy-based RDN system...
May 18, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29765015/reduction-of-blood-pressure-following-after-renal-artery-adventitia-stripping-during-total-nephroureterectomy-potential-effect-of-renal-sympathetic-denervation
#3
Keisuke Okamura, Shunsuke Satou, Keita Setojima, Shinjiro Shono, Shigero Miyajima, Tatsu Ishii, Kazuyuki Shirai, Hidenori Urata
BACKGROUND Catheter-based renal sympathetic denervation has been reported to be effective for treatment resistance hypertension in Australia and Europe. However, in the blinded SYMPLICITY HTN-3 trial, renal denervation did not achieve a significant decrease in blood pressure (BP) in comparison to sham controls. There have been various discussions on the factors that influenced this result. CASE REPORT Two men on antihypertensive therapy underwent unilateral radical nephroureterectomy for cancer of the renal pelvis...
May 16, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29760664/reduced-renal-mass-salt-sensitive-hypertension-is-resistant-to-renal-denervation
#4
Ionut Tudorancea, Thomas E Lohmeier, Barbara T Alexander, Dragos Pieptu, Dragomir N Serban, Radu Iliescu
Aim: Activation of the sympathetic nervous system is common in resistant hypertension (RHT) and also in chronic kidney disease (CKD), a prevalent condition among resistant hypertensives. However, renal nerve ablation lowers blood pressure (BP) only in some patients with RHT. The influence of loss of nephrons per se on the antihypertensive response to renal denervation (RDNx) is unclear and was the focus of this study. Methods: Systemic hemodynamics and sympathetically mediated low frequency oscillations of systolic BP were determined continuously from telemetrically acquired BP recordings in rats before and after surgical excision of ∼80% of renal mass and subsequent RDNx...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29744617/cardiac-magnetic-resonance-assessment-of-central-and-peripheral-vascular-function-in-patients-undergoing-renal-sympathetic-denervation-as-predictor-for-blood-pressure-response
#5
Karl Fengler, Karl-Philipp Rommel, Stephan Blazek, Maximilian Von Roeder, Christian Besler, Christian Lücke, Matthias Gutberlet, Jennifer Steeden, Michael Quail, Steffen Desch, Holger Thiele, Vivek Muthurangu, Philipp Lurz
BACKGROUND: Most trials regarding catheter-based renal sympathetic denervation (RDN) describe a proportion of patients without blood pressure response. Recently, we were able to show arterial stiffness, measured by invasive pulse wave velocity (IPWV), seems to be an excellent predictor for blood pressure response. However, given the invasiveness, IPWV is less suitable as a selection criterion for patients undergoing RDN. Consequently, we aimed to investigate the value of cardiac magnetic resonance (CMR) based measures of arterial stiffness in predicting the outcome of RDN compared to IPWV as reference...
May 9, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29739333/renal-denervation-improves-cardiac-function-by-attenuating-myocardiocyte-apoptosis-in-dogs-after-myocardial-infarction
#6
Li Wang, Lijun Song, Chao Li, Qiaoli Feng, Mengping Xu, Zhuqing Li, Chengzhi Lu
BACKGROUND: Myocardial apoptosis is important in the pathogenesis and progression of myocardial infarction-induced heart failure (MI-HF). Renal sympathetic denervation (RDN) has become a promising therapeutic strategy for the treatment of HF. Previous studies have shown that RDN could improve heart function Yao et al. (Exp Ther Med 14:4104-4110, 2017). However, whether and how RDN regulates myocardial apoptosis in MI-HF is unclear. This study sought to evaluate the effects of RDN on cardiac function and apoptosis-related gene expression in MI-HF dogs...
May 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29717380/selective-vs-global-renal-denervation-a-case-for-less-is-more
#7
REVIEW
Marat Fudim, Asher A Sobotka, Yue-Hui Yin, Joanne W Wang, Howard Levin, Murray Esler, Jie Wang, Paul A Sobotka
PURPOSE OF REVIEW: Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiority of selective RDN. RECENT FINDINGS: Recent trials testing the efficacy of RDN showed mixed results. Initial investigations targeted global RDN as a therapeutic goal. The repeat observation of heterogeneous response to RDN including non-responders with lack of a BP reduction, or even more unsettling, BP elevations after RDN has raised concern for the detrimental effects of unselective global RDN...
May 1, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29700056/ablation-of-the-ligament-of-marshall-and-left-stellate-ganglion-similarly-reduces-ventricular-arrhythmias-during-acute-myocardial-infarction
#8
Shan Liu, Xiaomei Yu, Da Luo, Zhiliang Qin, Xiaoying Wang, Wenbo He, Ruisong Ma, Huihui Hu, Jing Xie, Bo He, Zhibing Lu, Hong Jiang
BACKGROUND: Sympathetic denervation exerts protective effects against ventricular arrhythmias (VAs) induced by acute myocardial infarction. The results of a previous study indicated that the distal part of the ligament of Marshall (LOMLSPV ) might be a sympathetic conduit between the left stellate ganglion (LSG) and the ventricles. The present study was designed to compare the effects between LSG and LOMLSPV ablation on ischemia-induced VAs. METHODS: Twenty-nine dogs were randomly divided into sham ablation group (group 1, n=9), LOMLSPV ablation group (group 2, n=10), and LSG ablation group (group 3, n=10)...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29694249/olmesartan-combined-with-renal-denervation-reduces-blood-pressure-in-association-with-sympatho-inhibitory-and-aldosterone-reducing-effects-in-hypertensive-mice-with-chronic-kidney-disease
#9
Masaaki Nishihara, Ko Takesue, Yoshitaka Hirooka
BACKGROUND: Augmented sympathetic nerve activity (SNA) and renin-angiotensin-aldosterone system (RAAS) activity are involved in the pathogenesis of hypertension (HT) accompanied by chronic kidney disease (CKD). Oxidative stress in the hypothalamus increases SNA in HT. Administration of an angiotensin ΙΙ receptor blocker (olmesartan; OLM) or renal denervation (RDN) exerts an antihypertensive effect in HT with CKD; however, the precise mechanisms of the combination therapy are not fully elucidated...
April 25, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29663677/the-carotid-sinus-nerve-structure-function-and-clinical-implications
#10
Andrea Porzionato, Veronica Macchi, Carla Stecco, Raffaele De Caro
Interest has been renewed in the anatomy and physiology of the carotid sinus nerve (CSN) and its targets (carotid sinus and carotid body, CB), due to recent proposals of surgical procedures for a series of common pathologies, such as carotid sinus syndrome, hypertension, heart failure, and insulin resistance. The CSN originates from the glossopharyngeal nerve soon after its appearance from the jugular foramen. It shows frequent communications with the sympathetic trunk (usually at the level of the superior cervical ganglion) and the vagal nerve (main trunk, pharyngeal branches, or superior laryngeal nerve)...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29657937/the-role-of-angiotensin-ii-infusion-on-the-baroreflex-sensitivity-and-renal-function-in-intact-and-bilateral-renal-denervation-rats
#11
Mohammad Karim Azadbakht, Jalal Hassanshahi, Mehdi Nematbakhsh
Background: The role of renin-angiotensin system (RAS) in communication between renal system and cardiovascular system is extremely important. Baroreflex sensitivity (BRS) index defines as heart rate (HR) alteration versus mean arterial pressure (MAP) change ratio . Sympathetic nerve is arm of the baroreflexes and any change in its activity will lead to change in the BRS. The role of angiotensin II (Ang II) infusion in systemic circulation accompanied with bilateral renal denervation (RDN) on BRS index and renal function was studied...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29652730/predictors-for-profound-blood-pressure-response-in-patients-undergoing-renal-sympathetic-denervation
#12
Karl Fengler, Karl-Philipp Rommel, Blazek Stephan, Maximilian von Roeder, Christian Besler, Philipp Hartung, Steffen Desch, Holger Thiele, Philipp Lurz
BACKGROUND: Renal sympathetic denervation (RDN) as treatment for hypertension shows highly variable results. Although some patients do not show any blood pressure (BP) change and in most patients a BP reduction of at least 5 mmHg can be found, some show a reduction at least 20 mmHg. We sought to identify predictors for such a profound BP response. METHODS: Profound BP response was defined as drop of at least 20 mmHg in daytime systolic ambulatory BP measurement (ABPM) 3 months after catheter-based RDN...
April 12, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29651618/effect-of-renal-sympathetic-denervation-on-ventricular-and-neural-remodeling
#13
L Wang, G Wei, L Song, C Li, F Zhang, Y Yang, C Lu
BACKGROUND: This study assessed the therapeutic effects of renal sympathetic denervation (RDN) on post-myocardial infarction (MI) ventricular remodeling and sympathetic neural remodeling in dogs. The possible mechanisms and optimal time for treatment are discussed. METHODS: We randomly assigned 30 dogs to five groups: RDN 1 week before MI (RDN1w + MI; n = 6), RDN 1 week after MI (MI1w + RDN; n = 6), RDN 2 weeks after MI (MI2w + RDN; n = 6), control (N; n = 6), and MI (n = 6)...
April 12, 2018: Herz
https://www.readbyqxmd.com/read/29651418/role-of-the-sympathetic-nervous-system-and-its-modulation-in-renal-hypertension
#14
REVIEW
Yusuke Sata, Geoffrey A Head, Kate Denton, Clive N May, Markus P Schlaich
The kidneys are densely innervated with renal efferent and afferent nerves to communicate with the central nervous system. Innervation of major structural components of the kidneys, such as blood vessels, tubules, the pelvis, and glomeruli, forms a bidirectional neural network to relay sensory and sympathetic signals to and from the brain. Renal efferent nerves regulate renal blood flow, glomerular filtration rate, tubular reabsorption of sodium and water, as well as release of renin and prostaglandins, all of which contribute to cardiovascular and renal regulation...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29645283/sympathoexcitation-following-intermittent-hypoxia-in-rat-is-mediated-by-circulating-angiotensin-ii-acting-at-the-carotid-body-and-subfornical-organ
#15
Seung Jae Kim, Angelina Y Fong, Paul M Pilowsky, Stephen B G Abbott
Circulating angiotensin II (AngII) is vital for arterial pressure elevation following intermittent hypoxia in rats, but its importance in the induction of sympathetic changes is unclear. We tested the contribution of the RAS to the effects of acute intermittent hypoxia (AIH) in anaesthetized ventilated adult rats. AIH caused a 33.7 ± 2.9% increase in sympathetic nerve activity (SNA), and a one-fold increase in sympathetic peripheral chemoreflex sensitivity and central sympathetic-respiratory coupling. The sympathetic effects of AIH were prevented by blocking angiotensin type 1 receptors with systemic losartan and intermittent systemic injections of AngII (Int...
April 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29643685/unilateral-brown-fat-suppression-on-fdg-pet-ct-detecting-sympathetic-denervation
#16
Saurabh Arora, Nishikant Avinash Damle, K Sreenivasa Reddy, Girish Kumar Parida, Abhinav Singhal, Sreedharan Thankarajan Arunraj, Chandrasekhar Bal, Roma Singh, Shobhana Raju, Dhritiman Chakraborty
We present here a case of primitive neuroectodermal tumor (PNET) who initially presented with involvement of the right 3rd rib and underwent neoadjuvant chemotherapy, rib excision, and adjuvant chemoradiotherapy and later underwent posterolateral thoracotomy, pleural nodule excision, and the right 11th rib metastatic lesion excision. Follow-up 18 F-FDG PET/CT/computed tomography revealed unilateral brown fat suppression in the form of decreased metabolic uptake in the ipsilateral cervical, axillary, and paravertebral brown fat as compared to metabolically active contralateral brown fat, likely due to paravertebral sympathetic chain damage...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29627741/effects-of-renal-sympathetic-denervation-on-myocardial-structure-function-and-perfusion-a-serial-cmr-study
#17
Sinny Delacroix, Ramesh G Chokka, Adam J Nelson, Dennis T Wong, Stephen Pederson, Joanne Nimmo, Adil Rajwani, Kerry Williams, Karen S Teo, Stephen G Worthley
BACKGROUND AND AIMS: Echocardiographic studies have shown improvements in cardiac indices associated with renal sympathetic denervation (RDN), however, the benefits on myocardial perfusion have never been assessed. This trial was designed to study the effects of RDN on myocardial perfusion using cardiac magnetic resonance (CMR) imaging. METHODS: A total of 14 patients with resistant hypertension were recruited for RDN and myocardial perfusion, alongside other CMR indices, was assessed at baseline and at 6 months...
March 10, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29610596/catecholaminergic-polymorphic-ventricular-tachycardia-looking-to-the-future
#18
Andreea Elena Velcea, Calin Siliste, Dragos Vinereanu
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inheritable cardiac disorder, characterized by polymorphic ventricular tachycardia (PVT) or bidirectional ventricular tachycardia, triggered by adrenergic stress, and manifested most frequently as syncope or sudden cardiac death. The disease has a heterogeneous genetic basis, with mutations in the genes encoding the ryanodine and calsequestrin channels accounting for the majority of cases. The diagnosis of CPVT is established in individuals with polymorphic ventricular premature beats, PVT or bidirectional ventricular tachycardia documented during exercise or adrenergic stress, who have a structurally normal heart and normal resting ECG...
December 2017: Mædica
https://www.readbyqxmd.com/read/29594117/erythrocyte-salt-sedimentation-assay-does-not-predict-response-to-renal-denervation
#19
Oliver Vonend, Ole Martin, Lars C Rump, Patrick Kroepil, Johannes Stegbauer
Renal denervation (RDN) has recently been shown to be effective in patients without antihypertensive medication. However, about 30% of patients do not respond to RDN, and therefore, there exists a need to find predictors of response. Individuals are either salt-sensitive (SS) or non-salt-sensitive (NSS) in terms of their blood pressure (BP) regulation. The sympathetic nervous system can influence water and salt handling. RDN reduces sympathetic drive and has an impact on salt excretion. The present study was conducted to test the influence of salt sensitivity in terms of the BP reducing effect after RDN procedure...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29575573/renal-sympathetic-denervation-ashes-to-ashes-or-rebirth-from-the-ashes
#20
Michael Doumas, Konstantinos Stavropoulos, Konstantinos P Imprialos, Vasilios G Athyros, Asterios Karagiannis
No abstract text is available yet for this article.
March 25, 2018: Journal of Clinical Hypertension
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