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https://www.readbyqxmd.com/read/27908698/potential-role-of-endurance-training-in-altering-renal-sympathetic-nerve-activity-in-ckd
#1
REVIEW
Erin J Howden, Justin S Lawley, Murray Esler, Benjamin D Levine
Chronic kidney disease (CKD), is characterized by a progressive loss of renal function and increase in cardiovascular risk. In this review paper, we discuss the pathophysiology of increased sympathetic nerve activity in CKD patients and raise the possibility of endurance exercise being an effective countermeasure to address this problem. We specifically focus on the potential role of endurance training in altering renal sympathetic nerve activity as increased renal sympathetic nerve activity negatively impacts kidney function as well indirectly effects multiple other systems and organs...
November 25, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27906840/renal-artery-denervation-for-treatment-of-patients-with-self-reported-obstructive-sleep-apnea-and-resistant-hypertension-results-from-the-global-symplicity-registry
#2
Dominik Linz, Giuseppe Mancia, Felix Mahfoud, Krzysztof Narkiewicz, Luis Ruilope, Markus Schlaich, Ingrid Kindermann, Roland E Schmieder, Sebastian Ewen, Bryan Williams, Michael Böhm
BACKGROUND: Sleep-disordered breathing, predominantly obstructive sleep apnea (OSA), is highly prevalent in patients with hypertension. OSA may underlie the progression to resistant hypertension, partly due to increased activation of the sympathetic nervous system. This analysis of patients with and without OSA evaluated the blood pressure (BP)-lowering effect of sympathetic modulation by renal denervation (RDN) in a real-world setting. METHODS: The Global SYMPLICITY Registry (NCT01534299) is a prospective, open-label, multicenter registry conducted worldwide to evaluate the safety and effectiveness of RDN in patients with uncontrolled hypertension...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27905168/editorial-can-renal-denervation-work-yes-but-first-one-must-denervate-lessons-from-human-renal-sympathetic-nerve-anatomy
#3
EDITORIAL
Tim A Fischell
No abstract text is available yet for this article.
December 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27890860/renal-denervation-by-ct-guided-periarterial-injection-of-hyperosmolar-saline-vincristine-paclitaxel-and-guanethidine-in-a-pig-model
#4
Patrick Freyhardt, Ricardo Donners, Alex Riemert, Jörg Schnorr, Nicola Stolzenburg, Jan Leo Rinnenthal, Ulrich Bernhardt, Bernd Hamm, Rolf W Günther, Florian Streitparth
AIMS: To evaluate feasibility, safety and efficacy of renal sympathetic denervation with CT- guided periarterial injection of potentially neurolytic agents in pigs. METHODS AND RESULTS: Unilateral injection of formulations containing either 5 M hyperosmolar saline, vincristine, paclitaxel or guanethidine around the renal artery was performed in 24 normotensive pigs with 6 animals per group. Needle placement and injections were performed under CT-fluoroscopy guidance...
November 29, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27890739/novel-insights-into-the-mechanisms-of-renal-sympathetic-denervation-induced-neuromodulation-in-controlling-atrial-arrhythmias-in-canines
#5
EDITORIAL
Annemiek F Hoogerwaard, Arif Elvan
No abstract text is available yet for this article.
November 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27889103/cardiac-autonomic-changes-after-thoracic-sympathectomy-a-prospective-randomized%C3%A2-study
#6
Alfonso Fiorelli, Giovanni Messina, Paolo Chiodini, Saveria Costanzo, Andrea Viggiano, Marcellino Monda, Giovanni Vicidomini, Mario Santini
BACKGROUND: We evaluated whether cardiac autonomic changes could be associated with different extent of sympathetic nerve resection in the management of essential palmar hyperhidrosis. METHODS: Sixty patients with essential palmar hyperhidrosis were randomly allocated to undergo excision of T3 ganglia (sympathicectomy group; n = 30) or to interruption of sympathetic chain at the T2 to T3 level with ganglion sparing (sympathicotomy group; n = 30). Time and frequency domains were measured with a 24-Holter monitor during daytime, nighttime, and 24-hour periods at different interval points (7 days before operation; 24 hours; and 1, 3, and 6 months later), and the differences were statistically compared...
November 23, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27881398/separate-and-shared-sympathetic-outflow-to-white-and-brown-fat-coordinately-regulate-thermoregulation-and-beige-adipocyte-recruitment
#7
Ngoc Ly T Nguyen, Candace L Barr, Vitaly Ryu, Qiang Cao, Bingzhong Xue, Timothy J Bartness
White adipose tissue (WAT) and brown adipose tissue (BAT) are innervated and regulated by the sympathetic nervous system (SNS). It is not clear, however, whether there are shared or separate central SNS outflows to WAT and BAT that regulate their function. We injected two isogenic strains of pseudorabies virus, a retrograde transneuronal viral tract tracer, with unique fluorescent reporters into interscapular BAT (IBAT) and inguinal WAT (IWAT) of the same Siberian hamsters to define SNS pathways to both. To test the functional importance of SNS coordinated control of BAT and WAT, we exposed hamsters with denervated SNS nerves to IBAT to 4°C for 16-24 hours, and measured core and fat temperatures, and norepinephrine turnover (NETO) and uncoupling protein 1 (UCP1) expression in fat tissues...
November 23, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27875730/contemporary-review-on-the-pathogenesis-of-takotsubo-syndrome-the-heart-shedding-tears-norepinephrine-churn-and-foam-at-the-cardiac-sympathetic-nerve-terminals
#8
REVIEW
Shams Y-Hassan, Rodney De Palma
Takotsubo syndrome (TS), an increasingly recognized acute cardiac disease entity, is characterized by a unique pattern of circumferential and typically regional left ventricular wall motion abnormality resulting in a conspicuous transient ballooning of the left ventricle during systole. The mechanism of the disease remains elusive. However, the sudden onset of acute myocardial stunning in a systematic pattern extending beyond a coronary artery territory; the history of a preceding emotional or physical stress factor in two thirds of cases; the signs of sympathetic denervation at the regions of left ventricular dysfunction on sympathetic scintigraphy; the finding of myocardial edema and other signs consistent with (catecholamine-induced) myocarditis shown by cardiac magnetic resonance imaging; and the contraction band necrosis on histopathological examination all argue strongly for the involvement of the cardiac sympathetic nervous system in the pathogenesis of TS...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27865077/renal-sympathetic-denervation-recalculating%C3%A2
#9
EDITORIAL
Jorge A Belardi, Mariano Albertal
No abstract text is available yet for this article.
November 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27856623/kisspeptin-level-in-the-aging-ovary-is-regulated-by-the-sympathetic-nervous-system
#10
Daniela Fernandois, Gonzalo Cruz, Eun Kyung Na, Hernán E Lara, Alfonso H Paredes
Previous work has demonstrated that the increase in the activity of sympathetic nerves, which occurs during the subfertility period in female rats, causes an increase in follicular cyst development and impairs follicular development. In addition, the increase in ovarian sympathetic activity of aged rats correlates with an increased expression of kisspeptin (KISS1) in the ovary. This increase in KISS1 could participate in the decrease in follicular development that occurs during the subfertility period. We aimed to determine whether the blockade of ovarian sympathetic tone prevents the increase in KISS1 expression during reproductive aging and improves follicular development...
January 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27849014/renal-artery-vasodilation-may-be-an-indicator-of-successful-sympathetic-nerve-damage-during-renal-denervation-procedure
#11
Weijie Chen, Huaan Du, Jiayi Lu, Zhiyu Ling, Yi Long, Yanping Xu, Peilin Xiao, Laxman Gyawali, Kamsang Woo, Yuehui Yin, Bernhard Zrenner
Autonomic nervous system plays a crucial role in maintaining and regulating vessel tension. Renal denervation (RDN) may induce renal artery vasodilation by damaging renal sympathetic fibers. We conducted this animal study to evaluate whether renal artery vasodilation could be a direct indicator of successful RDN. Twenty-eight Chinese Kunming dogs were randomly assigned into three groups and underwent RDN utilizing temperature-controlled catheter (group A, n = 11) or saline-irrigated catheter (group B, n = 11) or sham procedure (group C, n = 6)...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27845300/effects-of-renal-sympathetic-denervation-on-cardiac-systolic-function-after-myocardial-infarction-in-rats
#12
Jiqun Guo, Zhongxia Zhou, Zhenzhen Li, Qian Liu, Guoqing Zhu, Qijun Shan
This study investigated the therapeutic effects of renal denervation on cardiac systolic function after myocardial infarction (MI) in rats and the mechanism involved. Fifty male SD rats were randomly assigned to the sham group (n = 15), the MI group (n = 20), and the MI plus renal denervation group (n = 15). MI was established through thoracotomic ligation of the anterior descending artery. Renal denervation was achieved by laparotomic stripping of the renal arterial adventitial sympathetic nerve, approximately 3 mm from the abdominal aorta...
September 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27827823/g-csf-induced-sympathetic-tone-provokes-fever-and-primes-anti-mobilizing-functions-of-neutrophils-via-pge2
#13
Yuko Kawano, Chie Fukui, Masakazu Shinohara, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Tomoyuki Furuyashiki, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama
Granulocyte colony-stimulating factor (G-CSF) is widely used for peripheral blood stem/progenitor mobilization. G-CSF causes low-grade fever that is ameliorated by non-steroidal anti-inflammatory drugs (NSAIDs), suggesting the activation of arachidonic acid (AA) cascade. How G-CSF regulated this reaction was assessed. G-CSF treatment in mice resulted in fever, which was canceled in prostaglandin E synthase (mPGES-1)-deficient mice. Mobilization efficiency was twice higher in chimeric mice lacking mPGES-1, specifically in hematopoietic cells, suggesting that PGE2 from hematopoietic cells modulated bone marrow (BM) microenvironment...
November 8, 2016: Blood
https://www.readbyqxmd.com/read/27826330/management-of-patients-with-long-qt-syndrome
#14
REVIEW
Yongkeun Cho
Long QT syndrome (LQTS) is a rare cardiac channelopathy associated with syncope and sudden death due to torsades de pointes and ventricular fibrillation. Syncope and sudden death are frequently associated with physical and emotional stress. Management of patients with LQTS consists of life-style modification, β-blockers, left cardiac sympathetic denervation (LCSD), and implantable cardioverter-defibrillator (ICD) implantation. Prohibition of competitive exercise and avoidance of QT-prolonging drugs are important issues in life-style modification...
November 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27815927/renal-denervation
#15
Mohammed Awais Hameed, Indranil Dasgupta
Sympathetic nervous system over-activity is closely linked with elevation of systemic blood pressure. Both animal and human studies suggest renal sympathetic nerves play an important role in this respect. Historically, modulation of sympathetic activity has been used to treat hypertension. More recently, catheter based renal sympathetic denervation was introduced for the management of treatment resistant hypertension. Sound physiological principles and surgical precedent underpin renal denervation as a therapy for treatment of resistant hypertension...
November 5, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27806766/-effect-of-autonomic-denervation-on-the-secretory-function-of-submandibular-glands
#16
X M Zhang, L L Wu, G Y Yu, Y Zhang
Submandibular gland is innervated by sympathetic and parasympathetic nerves, both of which work synergistically to promote the salivation of the glands. However, denervation does not always produce an inhibitive effect. Regeneration secretion was put forward to describe the situation in which the glands after denervation were found to be supersensitive to the stimulation of several agonists of saliva secretion-related receptors. It is of clinical significance to get a good understanding of the secretory mechanism changes in the autonomically denervated submandibular gland...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27796855/mental-stress-and-ventricular-arrhythmias
#17
REVIEW
Rachel Lampert
Anger and other negative emotions can precipitate sudden death, as shown in studies of population stressors. Clinical studies of patients with implantable defibrillators demonstrate that anger can trigger ventricular arrhythmias. Long-term negative emotions also increase vulnerability to arrhythmias. Mechanisms linking anger and arrhythmias include autonomic changes, which alter repolarization, possibly enhanced in patients with sympathetic denervation, which in turn trigger potentially lethal polymorphic ventricular tachycardias...
December 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27775435/copeptin-resistant-hypertension-and-renal-sympathetic-denervation
#18
Marius Schwerg, Anna Slagman, Karl Stangl, Verena Stangl
BACKGROUND: Renal denervation is used as a treatment option for patients with resistant hypertension. But only a subgroup of patients benefits from RDN. Biomarkers might be helpful to identify patients who respond to RDN. Copeptin as a surrogate for vasopressin levels is increased in hypertension and other cardiovascular diseases. This study aims to evaluate the effect of RDN on Copeptin and its prognostic value for response to RDN. METHOD AND RESULTS: A total of 40 patients have been included in the study...
October 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27772769/cardiovascular-dysfunction-in-untreated-parkinson-s-disease-a-multi-modality-assessment
#19
Stefano Strano, Alessandra Fanciulli, Massimiliano Rizzo, Paolo Marinelli, Paolo Palange, Dorina Tiple, Giuseppe De Vincentis, Giovanni Calcagnini, Federica Censi, Giuseppe Meco, Carlo Colosimo
BACKGROUND: The clinical presentation of Parkinson's disease (PD) includes a wide spectrum of non-motor features, including cardiovascular autonomic failure. OBJECTIVE: To evaluate cardiovascular autonomic status and cardiac functional capacity in drug-naïve PD patients. METHODS: 18 newly-diagnosed PD patients underwent laboratory cardiovascular autonomic function tests using power spectral analysis of the R-R interval, blood pressure (BP) short-term variability and non-invasive baroreflex sensitivity (BRS)...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27761157/current-topics-in-catecholaminergic-polymorphic-ventricular-tachycardia
#20
Naokata Sumitomo
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by emotions or exercise in patients without organic heart disease and may be polymorphic or bidirectional in nature. The prognosis of CPVT is not good, and therefore prevention of sudden death is of utmost importance. Genetic variants of CPVT include RyR2, CASQ2, CALM2, TRD, and possibly KCNJ2 and ANK2 gene mutations. Hypotheses that suggest the causes of CPVT include weakened binding of FKBP12.6 and RyR2, a store overload-induced Ca(2+) release (SOICR), unzipping of intramolecular domain interactions in RyR2, and molecular and functional abnormalities caused by mutations in the CASQ2 gene...
October 2016: Journal of Arrhythmia
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