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REVIEW
Davide Graci, Nicolò Piazza, Salvatore Ardagna, Alessandra Casuccio, Anton Drobov, Federica Geraci, Angelo Immordino, Alessandra Pirrello, Vincenzo Restivo, Riccardo Rumbo, Rosalba Stefano, Roberta Virone, Elena Zarcone, Palmira Immordino
Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally and a primary cause of cervical cancer, which ranks fourth among tumors in both incidence and mortality. Despite the availability of effective vaccines worldwide, HPV vaccination rates vary, especially among migrant and refugee populations. Indeed, migrant status may act as a determinant against accessing vaccinations, among many other factors. The objective of this paper is to evaluate barriers to and facilitators for accessing HPV vaccination in migrant and refugee populations...
February 29, 2024: Vaccines
#2
JOURNAL ARTICLE
Sara Terzoli, Paolo Marzano, Valentina Cazzetta, Rocco Piazza, Inga Sandrock, Sarina Ravens, Likai Tan, Immo Prinz, Simone Balin, Michela Calvi, Anna Carletti, Assunta Cancellara, Nicolò Coianiz, Sara Franzese, Alessandro Frigo, Antonio Voza, Francesca Calcaterra, Clara Di Vito, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-CoV-2 vaccination. While the first dose of vaccine primes Vδ2 T cells, it is the second administration that significantly boosts their immune response. Specifically, the second vaccination uncovers memory features of Vδ2 T cells, shaped by the induction of AP-1 family transcription factors and characterized by a convergent central memory signature, clonal expansion, and an enhanced effector potential...
March 20, 2024: NPJ Vaccines
#3
JOURNAL ARTICLE
Elie Akl, Nazanin Sahami, Christopher Labos, Jacques Genest, Ali Zgheib, Nicolo Piazza, Sanjit Jolly
BACKGROUND: Colchicine has shown potential cardioprotective effects owing to its broad anti-inflammatory properties. We performed a meta-analysis to assess its safety and efficacy in secondary prevention in patients with established coronary artery disease (CAD). METHODS: We searched Ovid Healthstar, MEDLINE, and Embase (inception to May 2022) for randomized controlled trials (RCTs) evaluating the cardiovascular effects of colchicine compared with placebo or usual care in patients with CAD...
2024: Journal of Interventional Cardiology
#4
MULTICENTER STUDY
Daniel Hagemeyer, Anas Merdad, Laura Villegas Sierra, Andrea Ruberti, Faraj Kargoli, Marine Bouchat, Mauro Boiago, Aris Moschovitis, Djeven P Deva, Lukas Stolz, Geraldine Ong, Mark D Peterson, Nicolo Piazza, Maurizio Taramasso, Nicolas Dumonteil, Thomas Modine, Azeem Latib, Fabien Praz, Jörg Hausleiter, Neil P Fam
BACKGROUND: Transcatheter tricuspid valve replacement (TTVR) abolishes tricuspid regurgitation (TR) and has emerged as a definitive treatment for TR. OBJECTIVES: The purpose of this multicenter, observational study was to determine the clinical characteristics and short-term outcomes of patients with TR screened for TTVR. METHODS: Patients underwent TTVR screening at 7 centers on a compassionate-use basis. The primary endpoints were NYHA functional class and TR grade at 30-day follow-up...
February 26, 2024: JACC. Cardiovascular Interventions
#5
JOURNAL ARTICLE
Ali Z Zgheib, Jennifer Jdaidani, Elie Akl, Suzan Khalil, Omar Chaabo, Nicolo Piazza, Fadi J Sawaya, Abdallah G Rebeiz
BACKGROUND: Rates of major bleeding and intraprocedural thrombotic events (IPTE) in the setting of percutaneous coronary intervention (PCI) using weight-adjusted unfractionated heparin (UFH) without activated clotting time (ACT) monitoring are not known. METHODS: We reviewed 2,748 consecutive patients who underwent coronary angiography at our tertiary care university hospital between January 2017 and December 2020. All patients who underwent PCI with weight-adjusted UFH without ACT guidance were considered for further analysis...
2024: International Journal of Clinical Practice
#6
JOURNAL ARTICLE
Xavier Armario, Jennifer Carron, Andrew J Simpkin, Mohamed Elhadi, Ciara Kennedy, Mohamed Abdel-Wahab, Sabine Bleiziffer, Thierry Lefèvre, Alexander Wolf, Thomas Pilgrim, Pedro A Villablanca, Daniel J Blackman, Nicolas M Van Mieghem, Christian Hengstenberg, Martin J Swaans, Bernard D Prendergast, Tiffany Patterson, Marco Barbanti, John G Webb, Miles Behan, Jon Resar, Mao Chen, David Hildick-Smith, Mark S Spence, David Zweiker, Rodrigo Bagur, Rui Teles, Flavio L Ribichini, Dariusz Jagielak, Duk-Woo Park, Ran Kornowski, Joanna J Wykrzykowska, Matjaz Bunc, Rodrigo Estévez-Loureiro, Karl Poon, Matthias Götberg, Raban V Jeger, Hüseyin Ince, Erik J S Packer, Marco Angelillis, Luis Nombela-Franco, Yingqiang Guo, Mikko Savontaus, Abdulrahman M Al-Moghairi, Catalina Andreea Parasca, Chad Kliger, David Roy, Levente Molnár, Mariana Silva, Jonathon White, Masanori Yamamoto, Pedro Carrilho-Ferreira, Stefan Toggweiler, Vassileios Voudris, Yohei Ohno, Inês Rodrigues, Radosław Parma, Soledad Ojeda, Kostas Toutouzas, Ander Regueiro, Marek Grygier, Khaled AlMerri, Ignacio Cruz-González, Viliam Fridrich, José M de la Torre Hernández, Stephane Noble, Petr Kala, Lluis Asmarats, Ibrahim Halil Kurt, Johan Bosmans, Martins Erglis, Ivan Casserly, Dounia Iskandarani, Ravinay Bhindi, Joelle Kefer, Wei-Hsian Yin, Liesbeth Rosseel, Hyo-Soo Kim, Stephen O'Connor, Farrel Hellig, Matias Sztejfman, Oscar Mendiz, Andres M Pineda, Ashok Seth, Elton Pllaha, Fabio S de Brito, Vilhelmas Bajoras, Mohammed A Balghith, Michael Lee, Guering Eid-Lidt, Bert Vandeloo, Vinicius Daher Vaz, Mirvat Alasnag, Gian Paolo Ussia, Edgar Tay, Jorge Mayol, Sengottuvelu Gunasekaran, Gennaro Sardella, Wacin Buddhari, Hsien-Li Kao, Antonio Dager, Apostolos Tzikas, Ingibjörg J Gudmundsdottir, Ahmad Edris, Luis Abel Gutiérrez Jaikel, Eduardo A Arias, Mohammed Al-Hijji, Mehmet Ertürk, César Conde-Vela, Darko Boljević, Adolfo Ferrero Guadagnoli, Toomas Hermlin, Ahmed M ElGuindy, Moysés de Oliveira Lima-Filho, Luciano de Moura Santos, Luis Perez, Gabriel Maluenda, Ali Rıza Akyüz, Imad A Alhaddad, Haitham Amin, Chak-Yu So, Arif A Al Nooryani, Carlos Vaca, Juan Albistur, Quang Ngoc Nguyen, Dabit Arzamendi, Eberhard Grube, Thomas Modine, Didier Tchétché, Kentaro Hayashida, Azeem Latib, Raj R Makkar, Nicolo Piazza, Lars Søndergaard, John William McEvoy, Darren Mylotte
BACKGROUND: The COVID-19 pandemic adversely affected health care systems. Patients in need of transcatheter aortic valve replacement (TAVR) are especially susceptible to treatment delays. OBJECTIVES: The study sought to evaluate the impact of the COVID-19 pandemic on global TAVR activity. METHODS: This international registry reported monthly TAVR case volume in participating institutions prior to and during the COVID-19 pandemic (January 2018 to December 2021)...
December 20, 2023: JACC. Cardiovascular Interventions
#7
JOURNAL ARTICLE
Nicolò Danesin, Alessandro Cellini, Francesco Piazza, Livio Trentin, Andrea Visentin
No abstract text is available yet for this article.
December 22, 2023: Medicina Clínica
#8
JOURNAL ARTICLE
Ali Zgheib, Elie Akl, Marco Spaziano, Giuseppe Martucci, Nicolo Piazza
We report the case of a 64-year-old man with a history of chemotherapy-induced cardiomyopathy requiring heart transplant in 2022 who underwent successful endomyocardial biopsy using patient-specific computed tomographic fluoroscopic projections. ( Level of Difficulty: Beginner. ).
November 15, 2023: JACC. Case reports
#9
JOURNAL ARTICLE
Rosie Fountotos, Sandra Lauck, Nicolo Piazza, Giuseppe Martucci, Rakesh Arora, Anita Asgar, Jessica Forcillo, Remi Kouz, Marino Labinaz, Andre Lamy, Mark Peterson, Harindra Wijeysundera, Lisa Masse, Marie-Claude Ouimet, Jopie Polderman, John Webb, Jonathan Afilalo
BACKGROUND: Despite the high procedural success of transcatheter aortic valve replacement (TAVR), 2 out of 5 older adults report poor physical performance and health-related quality of life (HRQOL) in the ensuing months, particularly those with frailty. There has yet to be a trial examining the synergistic effects of exercise and protein supplementation to counteract frailty and improve patient-centered outcomes following TAVR. METHODS: The PERFORM-TAVR trial is a multicenter parallel-group randomized clinical trial that is enrolling 200 frail older adults ≥70 years undergoing TAVR (NCT03522454)...
December 3, 2023: Canadian Journal of Cardiology
#10
JOURNAL ARTICLE
Nicolo Rossi, Nicola Gigante, Nicola Vitacolonna, Carla Piazza
The field of tumor phylogenetics focuses on studying the differences within cancer cell populations. Many efforts are done within the scientific community to build cancer progression models trying to understand the heterogeneity of such diseases. These models are highly dependent on the kind of data used for their construction, therefore, as the experimental technologies evolve, it is of major importance to exploit their peculiarities. In this work we describe a cancer progression model based on Single Cell DNA Sequencing data...
November 28, 2023: IEEE/ACM Transactions on Computational Biology and Bioinformatics
#11
JOURNAL ARTICLE
Leonhard-Moritz Schneider, Stephen Worthley, Georg Nickenig, Zenon Huczek, Wojtek Wojakowski, Didier Tchetche, Christophe Dubois, Malek Nasr, Luc Verhees, Martin Rothman, Nicolo Piazza, Jean Buithieu, Wen-Loong Yeow, Mirjam Keßler, Wolfgang Rottbauer
BACKGROUND: A significant number of patients with severe mitral regurgitation (MR) are not suitable for either surgical or transcatheter edge-to-edge repair because of high surgical risk or inappropriate mitral valve anatomy. OBJECTIVES: The aim of this study was to evaluate the HighLife Trans-Septal Mitral Valve Replacement (TSMVR) system in patients with symptomatic MR and high surgical risk. METHODS: This prospective, multicenter, nonrandomized feasibility study evaluated the safety and performance of the HighLife TSMVR system in patients with moderate to severe or severe symptomatic MR during 1-year follow-up...
November 16, 2023: JACC. Cardiovascular Interventions
#12
JOURNAL ARTICLE
Francesco Maisano, Nicolo Piazza, Bernard Prendergast, Simon Redwood, Didier Tchétché, Nina C Wunderlich, Pcr London Valves Course Directors
No abstract text is available yet for this article.
November 17, 2023: EuroIntervention
#13
JOURNAL ARTICLE
Nozomi Kotoku, Kai Ninomiya, Daixin Ding, Neil O'Leary, Akihiro Tobe, Kotaro Miyashita, Shinichiro Masuda, Shigetaka Kageyama, Scot Garg, Jonathon A Leipsic, Saima Mushtaq, Daniele Andreini, Kaoru Tanaka, Johan de Mey, William Wijns, Shengxian Tu, Nicolo Piazza, Yoshinobu Onuma, Patrick W Serruys
Murray law-based quantitative flow ratio (µQFR) assesses fractional flow reserve (FFR) in bifurcation lesions using a single angiographic view, enhancing the feasibility of analysis; however, accuracy may be compromised in suboptimal angiographic projections. FFRCT is a well-validated non-invasive method measuring FFR from coronary computed tomographic angiography (CCTA). We evaluated the feasibility of µQFR in left main (LM) bifurcations, the impact of the optimal/suboptimal fluoroscopic view with respect to CCTA, and its diagnostic concordance with FFRCT ...
October 23, 2023: International Journal of Cardiovascular Imaging
#14
JOURNAL ARTICLE
Jingjing He, Tian-Yuan Xiong, Yi-Jun Yao, Yong Peng, Jia-Fu Wei, Zhen-Gang Zhao, Guo Chen, Yuan-Weixiang Ou, Qi Liu, Xi Wang, Zhongkai Zhu, Hao-Ran Yang, Kaiyu Jia, Darren Mylotte, Nicolo Piazza, Bernard Prendergast, Yuan Feng, Mao Chen
BACKGROUND: Data concerning the outcomes of transcatheter aortic valve replacement in type 0 bicuspid aortic stenosis (AS) are scarce. The study aims to compare the outcomes of transcatheter aortic valve replacement for AS in patients with type 0 bicuspid, type 1 bicuspid, and tricuspid aortic valve anatomy. METHODS: We enrolled consecutive patients undergoing transcatheter aortic valve replacement for severe AS between 2012 and 2022 in this single-center retrospective cohort study...
October 17, 2023: Circulation. Cardiovascular Interventions
#15
JOURNAL ARTICLE
Nicolò Danesin, Mariella Lo Schirico, Greta Scapinello, Angela Grassi, Marcello Riva, Tamara Berno, Antonio Branca, Andrea Visentin, Marco Carraro, Laura Pavan, Sabrina Manni, Laura Bonaldi, Annalisa Martines, Roberta Bertorelle, Fabrizio Vianello, Carmela Gurrieri, Chiara Briani, Renato Zambello, Livio Trentin, Francesco Piazza
No abstract text is available yet for this article.
October 2023: HemaSphere
#16
EDITORIAL
Sheldon Magder, Nicolo Piazza
No abstract text is available yet for this article.
September 25, 2023: JACC. Cardiovascular Interventions
#17
REVIEW
Julia Grapsa, Fabien Praz, Paul Sorajja, Joao L Cavalcante, Marta Sitges, Maurizio Taramasso, Nicolo Piazza, David Messika-Zeitoun, Hector I Michelena, Nadira Hamid, Julien Dreyfus, Giovanni Benfari, Edgar Argulian, Alaide Chieffo, Didier Tchetche, Lawrence Rudski, Jeroen J Bax, Ralph Stephan von Bardeleben, Tiffany Patterson, Simon Redwood, Vinayak N Bapat, Georg Nickenig, Philipp Lurz, Jörg Hausleiter, Susheel Kodali, Rebecca T Hahn, Francesco Maisano, Maurice Enriquez-Sarano
Tricuspid regurgitation (TR) is a highly prevalent and heterogeneous valvular disease, independently associated with excess mortality and high morbidity in all clinical contexts. TR is profoundly undertreated by surgery and is often discovered late in patients presenting with right-sided heart failure. To address the issue of undertreatment and poor clinical outcomes without intervention, numerous structural tricuspid interventional devices have been and are in development, a challenging process due to the unique anatomic and physiological characteristics of the tricuspid valve, and warranting well-designed clinical trials...
January 2024: JACC. Cardiovascular Imaging
#18
JOURNAL ARTICLE
Andrea Colautti, Nicolò Rossi, Carla Piazza, Giuseppe Comi, Lucilla Iacumin
Lactobacilli have a fundamental role in the food industry as starters and probiotics, therefore, requiring special attention concerning food safety. In this work, 14 strains selected accordingly to their genetic fingerprint and physiologic characteristics are presented as representatives of a collection of 200 strains.
September 1, 2023: Microbiology Resource Announcements
#19
REVIEW
Mahmoud Abdelshafy, Patrick W Serruys, Tsung-Ying Tsai, Pruthvi Chenniganahosahalli Revaiah, Scot Garg, Jean-Paul Aben, Carl J Schultz, Mohammad Abdelghani, Pim A L Tonino, Yosuke Miyazaki, Marcel C M Rutten, Martijn Cox, Cherif Sahyoun, Justin Teng, Hiroki Tateishi, Mohamed Abdel-Wahab, Nicolo Piazza, Michele Pighi, Rodrigo Modolo, Martijn van Mourik, Joanna Wykrzykowska, Robbert J de Winter, Pedro A Lemos, Fábio S de Brito, Hideyuki Kawashima, Lars Søndergaard, Liesbeth Rosseel, Rutao Wang, Chao Gao, Ling Tao, Andreas Rück, Won-Keun Kim, Niels van Royen, Christian J Terkelsen, Henrik Nissen, Matti Adam, Tanja K Rudolph, Hendrik Wienemann, Ryo Torii, Franz Josef Neuman, Simon Schoechlin, Mao Chen, Ahmed Elkoumy, Hesham Elzomor, Ignacio J Amat-Santos, Darren Mylotte, Osama Soliman, Yoshinobu Onuma
Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models...
2023: Frontiers in Cardiovascular Medicine
#20
JOURNAL ARTICLE
Didier Tchetche, Francesca Ziviello, Chiara De Biase, Ole de Backer, Thomas Hovasse, Lionel Leroux, Anna-Sonia Petronio, Christophe Saint-Etienne, Rui Campante Teles, Thomas Modine, Arnaud Sudre, Emmanuel Teiger, Darren Mylotte, Geraud Souteyrand, Nicolo Piazza, Frederic Casassus, Lars Sondergaard, Marco Angelillis, Tiago Nolasco, Saiffullah Siddiqui, Isabella Kardys, Nicolas Dumonteil, Nicolas M Van Mieghem
BACKGROUND: Prospective data about transcatheter aortic valve implantation (TAVI) in bicuspid aortic valve (BAV) patients are limited. AIMS: We aimed to evaluate the clinical impact of the Evolut PRO and R (34 mm) self-expanding prostheses in BAV patients and explore the impact of different computed tomography (CT) sizing algorithms in a prospective registry. METHODS: A total of 149 bicuspid patients were treated in 14 countries...
May 18, 2023: EuroIntervention
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