keyword
MENU ▼
Read by QxMD icon Read
search

caffeine and performance

keyword
https://www.readbyqxmd.com/read/29779481/absorptive-and-secretory-transport-of-selected-artemisinin-derivatives-across-caco-2-cell-monolayers
#1
Jaco Heyns, Clarissa Willers, Richard K Haynes, Ho N Wong, Josias H Hamman, Chrisna Gouws
Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by the ongoing emergence of parasite resistance. For any new drugs, however, knowledge of their membrane permeability is an essential pre-requisite for eventual use. Treatment failure and emergence of resistance can occur as a result of reduced availability of the drug at the desired site of action. Cell-based permeability assays such as Caco-2 cell monolayers serve as a model for predicting drug absorption and efflux, and provide an estimate of drug bioavailability...
May 18, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29771141/headache-comorbidities-and-lifestyle-in-an-adolescent-population-the-teens-study
#2
Marta Torres-Ferrus, Carme Vila-Sala, Manuel Quintana, Sara Ajanovic, Victor José Gallardo, Juan Bernardo Gomez, José Alvarez-Sabin, Alfons Macaya, Patricia Pozo-Rosich
Objective To evaluate the prevalence and characteristics of headache and its relationship with comorbidities and lifestyle in a teenage population. Methods This is a cross-sectional study. Data was collected from students aged 12-18 years from six different schools in Catalonia, Spain. They completed an anonymous questionnaire with demographic, lifestyle, medical data, presence of recurrent headaches and its features, and completed the Strengths and Difficulties Questionnaire. We defined probable migraine if headache presented ≥ 3 ICHD-3 beta criteria for migraine...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29770579/cholinesterase-targeting-by-polyphenols-a-therapeutic-approach-for-the-treatment-of-alzheimer-s-disease
#3
REVIEW
Nasimudeen R Jabir, Fayaz Rahman Khan, Shams Tabrez
Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances...
May 16, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29765059/postnatal-microstructural-developmental-trajectory-of-corpus-callosum-subregions-and-relationship-to-clinical-factors-in-very-preterm-infants
#4
Radhika Teli, Margaret Hay, Alexa Hershey, Manoj Kumar, Han Yin, Nehal A Parikh
Our objectives were to define the microstructural developmental trajectory of six corpus callosum subregions and identify perinatal clinical factors that influence early development of these subregions in very preterm infants. We performed a longitudinal cohort study of very preterm infants (32 weeks gestational age or younger) (N = 36) who underwent structural MRI and diffusion tensor imaging serially at four time points - before 32, 32, 38, and 52 weeks postmenstrual age. We divided the corpus callosum into six subregions, performed probabilistic tractography, and used linear mixed effects models to evaluate the influence of antecedent clinical factors on its microstructural growth trajectory...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29763642/a-new-insight-into-the-oxidative-mechanism-of-caffeine-and-related-methylxanthines-in-aprotic-medium-may-caffeine-be-really-considered-as-an-antioxidant
#5
Rita Petrucci, Giuseppe Zollo, Antonella Curulli, Giancarlo Marrosu
BACKGROUND: Antioxidant properties have been recently suggested for caffeine that seems showing protective effects against damages caused by oxidative stress. In particular, a HO scavenging activity has been ascribed to caffeine. Even if the oxidation of caffeine has been widely studied, the antioxidant mechanism is still far to be understood. METHODS: The electrochemical behavior of caffeine, theobromine and theophylline was studied in aprotic medium by cyclic voltammetry and electrolysis in UV-vis cell; a computational analysis of the molecular structures based on the Density Functional Theory was performed; the reactivity of all substrates towards lead dioxide, superoxide and galvinoxyl radical was followed by UV-vis spectrophotometry...
May 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29761705/dopamine-and-caffeine-encapsulation-within-boron-nitride-14-0-nanotubes-classical-molecular-dynamics-and-first-principles-calculations
#6
Dolores Garcia-Toral, Minerva Gonzalez Melchor, Juan Francisco Rivas-Silva, Efrain Meneses-Juarez, Jose Cano-Ordaz, Gregorio Hernandez Cocoletzi
Classical molecular dynamics (MD) and density functional theory (DFT) calculations are developed to investigate the dopamine and caffeine encapsulation within boron nitride (BN) nanotubes (NT) with (14, 0) chirality. Classical MD studies are done at canonical and isobaric-isothermal conditions at 298 K and 1 bar in explicit water. Results reveal that both molecules are attracted by the nanotube, however only dopamine is able to enter the nanotube while the caffeine moves at the vicinity of it, suggesting that both species can be transported: the first by encapsulation and the second by drag...
May 15, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29757951/caffeine-related-deaths-manner-of-deaths-and-categories-at-risk
#7
REVIEW
Simone Cappelletti, Daria Piacentino, Vittorio Fineschi, Paola Frati, Luigi Cipolloni, Mariarosaria Aromatario
Caffeine is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet markets. Mechanisms of action are dose-dependent. Serious toxicities such as seizure and cardiac arrhythmias, seen with caffeine plasma concentrations of 15 mg/L or higher, have caused poisoning or, rarely, death; otherwise concentrations of 3⁻6 mg/kg are considered safe. Caffeine concentrations of 80⁻100 mg/L are considered lethal...
May 14, 2018: Nutrients
https://www.readbyqxmd.com/read/29753010/determination-of-the-mutational-landscape-in-taiwanese-patients-with-papillary-thyroid-cancer-by-whole-exome-sequencing
#8
Chun-Chi Chang, Ya-Sian Chang, Hsi-Yuan Huang, Kun-Tu Yeh, Ta-Chih Liu, Jan-Gowth Chang
Among women in Taiwan, thyroid cancer is the fifth most common malignant neoplasia. However, genomic profiling of papillary thyroid cancer (PTC) cases from Taiwan has not been attempted previously. We used whole-exome sequencing to identify mutations in a cohort of 19 PTC patients. Sequencing was performed using the Illumina system; Sanger sequencing was used to validate all identified mutations. We identified new somatic mutations in APC, DICER1, LRRC8D and NDRG1. We also found somatic mutations in ARID5A, CREB3L2, MDM4, PPP2R5A and TFPT; mutations in these genes had been found previously in other tumors, but had not been described previously in PTC...
May 9, 2018: Human Pathology
https://www.readbyqxmd.com/read/29749988/amelioration-of-pentylenetetrazole-induced-seizures-by-modulators-of-sigma-n-methyl-d-aspartate-and-ryanodine-receptors-in-mice
#9
Mojtaba Keshavarz, Behdad Yekzaman
Background: Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol. Methods: PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8)...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29748893/new-fluorescence-spectroscopic-method-for-the-simultaneous-determination-of-alkaloids-in-aqueous-extract-of-green-coffee-beans
#10
Hagos Yisak, Mesfin Redi-Abshiro, Bhagwan Singh Chandravanshi
BACKGROUND: There is no fluorescence spectroscopic method for the determination of trigonelline and theobromine in green coffee beans. Therefore, the objective of this study was to develop a new fluorescence spectroscopic method to determine the alkaloids simultaneously in the aqueous extract of green coffee beans. RESULTS: The calibration curves were linear in the range 2-6, 1-6, 1-5 mg/L for caffeine, theobromine and trigonelline, respectively, with R2  ≥ 0...
May 11, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29747888/optimizing-caffeine-use-and-risk-of-bronchopulmonary-dysplasia-in-preterm-infants-a-systematic-review-meta-analysis-and-application-of-grading-of-recommendations-assessment-development-and-evaluation-methodology
#11
REVIEW
Mitali Atul Pakvasa, Vivek Saroha, Ravi Mangal Patel
Caffeine reduces the risk of bronchopulmonary dysplasia (BPD). Optimizing caffeine use could increase therapeutic benefit. We performed a systematic-review and random-effects meta-analysis of studies comparing different timing of initiation and dose of caffeine on the risk of BPD. Earlier initiation, compared to later, was associated with a decreased risk of BPD (5 observational studies; n = 63,049, adjusted OR 0.69; 95% CI 0.64-0.75, GRADE: low quality). High-dose caffeine, compared to standard-dose, was associated with a decreased risk of BPD (3 randomized trials, n = 432, OR 0...
June 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/29740190/does-duration-of-caffeine-therapy-in-preterm-infants-born-%C3%A2-1250-g-at-birth-influence-neurodevelopmental-nd-outcomes-at-3-years-of-age
#12
A Lodha, Y Rabi, A Soraisham, J Dobry, Arijit Lodha, H Amin, E Al Awad, S Tang, A Sahai, V Bhandari
OBJECTIVE: To evaluate the effect of duration of caffeine use on long-term neurodevelopmental (ND) outcomes at 3 years corrected age (CA) in preterm infants with birthweights (BW) ≤ 1250 g. DESIGN/METHODS: All surviving infants with BW ≤ 1250 g admitted to the Foothills Medical Center neonatal intensive care unit (NICU) from January 2002 to December 2009 who received the first dose of caffeine in the first week of life and were followed up at three years CA were included in the study...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29729502/sucrose-or-sucrose-and-caffeine-differentially-impact-memory-and-anxiety-like-behaviours-and-alter-hippocampal-parvalbumin-and-doublecortin
#13
Tanya J Xu, Amy C Reichelt
Caffeinated sugar-sweetened "energy" drinks are a subset of soft drinks that are popular among young people worldwide. High sucrose diets impair cognition and alter aspects of emotional behaviour in rats, however, little is known about sucrose combined with caffeine. Rats were allocated to 2 h/day 10% sucrose (Suc), 10% sucrose plus 0.04% caffeine (CafSuc) or control (water) conditions. The addition of caffeine to sucrose appeared to increase the rewarding aspect of sucrose, as the CafSuc group consumed more solution than the Suc group...
April 11, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29704947/drowsiness-measures-for-commercial-motor-vehicle-operations
#14
Amy R Sparrow, Cynthia M LaJambe, Hans P A Van Dongen
Timely detection of drowsiness in Commercial Motor Vehicle (C MV) operations is necessary to reduce drowsiness-related CMV crashes. This is relevant for manual driving and, paradoxically, even more so with increasing levels of driving automation. Measures available for drowsiness detection vary in reliability, validity, usability, and effectiveness. Passively recorded physiologic measures such as electroencephalography (EEG) and a variety of ocular parameters tend to accurately identify states of considerable drowsiness, but are limited in their potential to detect lower levels of drowsiness...
April 25, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29703929/non-contact-identification-and-differentiation-of-illicit-drugs-using-fluorescent-films
#15
Ke Liu, Congdi Shang, Zhaolong Wang, Yanyu Qi, Rong Miao, Kaiqiang Liu, Taihong Liu, Yu Fang
Sensitive and rapid identification of illicit drugs in a non-contact mode remains a challenge for years. Here we report three film-based fluorescent sensors showing unprecedented sensitivity, selectivity, and response speed to the existence of six widely abused illicit drugs, including methamphetamine (MAPA), ecstasy, magu, caffeine, phenobarbital (PB), and ketamine in vapor phase. Importantly, for these drugs, the sensing can be successfully performed after 5.0 × 105 , 4.0 × 105 , 2.0 × 105 , 1...
April 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29702422/assessing-the-removal-of-organic-micropollutants-by-a-novel-baffled-osmotic-membrane-bioreactor-microfiltration-hybrid-system
#16
Nirenkumar Pathak, Sheng Li, Youngjin Kim, Laura Chekli, Sherub Phuntsho, Am Jang, Noreddine Ghaffour, TorOve Leiknes, Ho Kyong Shon
A novel approach was employed to study removal of organic micropollutants (OMPs) in a baffled osmotic membrane bioreactor-microfiltration (OMBR-MF) hybrid system under oxicanoxic conditions. The performance of OMBR-MF system was examined employing three different draw solutes (DS), and three model OMPs. The highest forward osmosis (FO) membrane rejection was attained with atenolol (100%) due to its higher molar mass and positive charge. With inorganic DS caffeine (94-100%) revealed highest removal followed by atenolol (89-96%) and atrazine (16-40%) respectively...
April 14, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29693564/cerebral-blood-flow-measurements-in-adults-a-review-on-the-effects-of-dietary-factors-and-exercise
#17
REVIEW
Peter J Joris, Ronald P Mensink, Tanja C Adam, Thomas T Liu
Improving cerebrovascular function may be a key mechanism whereby a healthy lifestyle, of which a healthy diet combined with increased physical activity levels is a cornerstone, protects against cognitive impairments. In this respect, effects on cerebral blood flow (CBF)—a sensitive physiological marker of cerebrovascular function—are of major interest. This review summarizes the impact of specific dietary determinants and physical exercise on CBF in adults and discusses the relation between these effects with potential changes in cognitive function...
April 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29686934/development-of-micellar-hplc-uv-method-for-determination-of-pharmaceuticals-in-water-samples
#18
Danielle Cristina da Silva, Cláudio Celestino Oliveira
Method for extraction and determination of amoxicillin, caffeine, ciprofloxacin, norfloxacin, tetracycline, diclofenac, ibuprofen, nimesulide, levonorgestrel, and 17 α -ethynylestradiol exploiting micellar liquid chromatography with PDA detector and solid-phase extraction was proposed. The usage of toxic solvents was low; the chromatographic separation of the medicaments was performed using a C18 column and mobile phases A and B containing 15.0% (v/v) ethanol, 3.0% (m/v) sodium dodecyl sulfate (SDS), and 0...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29679703/pc-pvt-2-0-an-updated-platform-for-psychomotor-vigilance-task-testing-analysis-prediction-and-visualization
#19
Jaques Reifman, Kamal Kumar, Maxim Y Khitrov, Jianbo Liu, Sridhar Ramakrishnan
BACKGROUND: The psychomotor vigilance task (PVT) has been widely used to assess the effects of sleep deprivation on human neurobehavioral performance. To facilitate research in this field, we previously developed the PC-PVT, a freely available software system analogous to the "gold-standard" PVT-192 that, in addition to allowing for simple visual reaction time (RT) tests, also allows for near real-time PVT analysis, predictions, and visualization in a personal computer (PC)...
April 18, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29671781/development-of-noninvasive-classification-methods-for-different-roasting-degrees-of-coffee-beans-using-hyperspectral-imaging
#20
Bingquan Chu, Keqiang Yu, Yanru Zhao, Yong He
This study aimed to develop an approach for quickly and noninvasively differentiating the roasting degrees of coffee beans using hyperspectral imaging (HSI). The qualitative properties of seven roasting degrees of coffee beans (unroasted, light, moderately light, light medium, medium, moderately dark, and dark) were assayed, including moisture, crude fat, trigonelline, chlorogenic acid, and caffeine contents. These properties were influenced greatly by the respective roasting degree. Their hyperspectral images (874⁻1734 nm) were collected using a hyperspectral reflectance imaging system...
April 19, 2018: Sensors
keyword
keyword
98598
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"