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caffeine and performance

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https://www.readbyqxmd.com/read/29141695/methylxanthines-induce-structural-and-functional-alterations-of-the-cardiac-system-in-zebrafish-embryos
#1
Ram Manohar Basnet, Daniela Zizioli, Michela Guarienti, Dario Finazzi, Maurizio Memo
BACKGROUND: Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline, doxofylline, etophylline, 3-isobutyl-1-methylxanthine (IBMX), pentoxifylline and theophylline. METHODS: Microinjections of the eight methylxanthines were performed in 1-2 cell stage zebrafish embryos and the general toxicity and cardiovascular effects were analyzed at different time points...
November 15, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29140142/coffee-ingestion-enhances-one-mile-running-race-performance
#2
Neil D Clarke, Darren L Richardson, James Thie, Richard Taylor
PURPOSE: Caffeine, often in the form of coffee, is frequently supplemented by athletes in an attempt to facilitate improved performance during exercise. The aim of the present study was to investigate the effectiveness of coffee ingestion as an ergogenic aid prior to a one-mile (1609 m) race. METHODS: In a double-blind, randomised, crossover, placebo-controlled design 13 trained male runners completed a one-mile race 60 minutes following the ingestion of 0.09 g·kg(-1) coffee (COF), 0...
November 15, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29136847/nitrogen-doped-carbon-nanotubes-decorated-poly-l-cysteine-as-a-novel-ultrasensitive-electrochemical-sensor-for-simultaneous-determination-of-theophylline-and-caffeine
#3
Yingzi Wang, Yaping Ding, Li Li, Ping Hu
In present study, a novel and facile electrochemical sensor based on glassy carbon electrode (GCE) modified with nitrogen-doped carbon nanotubes (N-CNT) decorated with poly (L-Cysteine) (PLCY) were fabricated and applied for the simultaneous voltammetric determination of theophylline (THEO) and caffeine (CAF). The morphology and structure of multilayer film modified on the surface of glassy carbon electrode were investigated successfully by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM) and Raman Spectroscopy...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29128774/the-effect-of-hydraulic-retention-time-in-onsite-wastewater-treatment-and-removal-of-pharmaceuticals-hormones-and-phenolic-utility-substances
#4
H Ejhed, J Fång, K Hansen, L Graae, M Rahmberg, J Magnér, E Dorgeloh, G Plaza
Micropollutants such as pharmaceuticals, hormones and phenolic utility chemicals in sewage water are considered to be an emerging problem because of increased use and observed adverse effects in the environment. The study provides knowledge on the removal efficiency of micropollutants with a range of physical and chemical properties in three commercially available onsite wastewater treatment facilities (OWTFs), tested on influent wastewater collected from 2500 person equivalents in Bildchen, Germany. A longer hydraulic retention time would in theory be expected to have a positive effect, and this study presents results for three different OWTFs in full-scale comparable tests under natural conditions...
November 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29113376/efficacy-of-glucocorticoids-vitamin-a-and-caffeine-therapies-for-neonatal-mortality-in-preterm-infants-a-network-meta-analysis
#5
Ying Li, Jie Gao, Qiwei Wang, Xiaojian Ma
Introduction: The paper aimed to evaluate the efficacy of different therapies in improving survival among preterm infants. Materials and Methods: PubMed and Embase were searched from inception to 2017. We assessed studies for eligibility and extracted data. A Bayesian random-effects model was used to evaluate different therapies combined direct comparisons with indirect evidence. Consistency analysis was achieved using node-splitting plots. Surface under the cumulative ranking curve (SUCRA) was calculated to rank different therapies...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29109686/ketone-diester-ingestion-impairs-time-trial-performance-in-professional-cyclists
#6
Jill J Leckey, Megan L Ross, Marc Quod, John A Hawley, Louise M Burke
We investigated the effect of pre- "race" ingestion of a 1,3-butanediol acetoacetate diester on blood ketone concentration, substrate metabolism and performance of a cycling time trial (TT) in professional cyclists. In a randomized cross-over design, 10 elite male cyclists completed a ~31 km laboratory-based TT on a cycling ergometer programmed to simulate the 2017 World Road Cycling Championships course. Cyclists consumed a standardized meal [2 g/kg body mass (BM) carbohydrate (CHO)] the evening prior to a trial day and a CHO breakfast (2 g/kg BM CHO) with 200 mg caffeine on the morning of a trial day...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29107974/significant-relationships-between-a-simple-marker-of-redox-balance-and-lifestyle-behaviours-relevance-to-the-framingham-risk-score
#7
Neda Seyedsadjadi, Jade Berg, Ayse A Bilgin, Chin Tung, Ross Grant
Oxidative stress has been closely linked to the progressive cell damage associated with emerging non-communicable disease (NCDs). Early detection of these biochemical abnormalities before irreversible cell damage occurs may therefore be useful in identifying disease risk at an individual level. In order to test this hypothesis, this study assessed the relationship between a simple measure of redox status and lifestyle risk factors for NCDs, and the population-based risk score of Framingham. In a cross-sectional study design, 100 apparently healthy middle-aged males (n = 48) and females (n = 52) were asked to complete a comprehensive lifestyle assessment questionnaire, followed by body fat percentage and blood pressure measurements, and blood collection...
2017: PloS One
https://www.readbyqxmd.com/read/29093334/behavioral-changes-and-survival-in-drosophila-melanogaster-effects-of-ascorbic-acid-taurine-and-caffeine
#8
Hyung Joo Suh, Byungsoo Shin, Sung-Hee Han, Moon Jea Woo, Ki-Bae Hong
In this study, we used Drosophila as a model species to examine the effects of vitamin or energy-drink and theses ingredients on behavioral activity, life-span, and survivorship. Behavioral assays were performed to analyze total activity during the subjective daytime and nighttime and the lifespan assay was performed to investigate the influence of the drink ingredients. Quantitative RT-PCR and enzyme activity analyses were applied to analyze the mutual relationship of neural pathways and anti-oxidant activities...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29091777/assessment-of-sleep-quality-in-bipolar-euthymic-patients
#9
Necla Keskin, Lut Tamam, Nurgul Ozpoyraz
OBJECTIVE: Sleep quality is affected in bipolar disorder even in euthymic episodes. The aim of this study was to assess sleep quality in bipolar euthymic patients, determine related clinical characteristics and evaluate its effects on functionality. METHODS: A total of 122 outpatients were included. Scales were used to confirm that patients were euthymic. Mini Mental Test was performed to exclude patients with a diagnosis of dementia. A data form for socio-demographic features and clinical characteristics of bipolar disorder have been completed...
September 30, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29091470/acute-ingestion-of-caffeinated-chewing-gum-improves-repeated-sprint-performance-of-team-sports-athletes-with-low-habitual-caffeine-consumption
#10
Mark Evans, Peter Tierney, Nicola Gray, Greg Hawe, Maria Macken, Brendan Egan
The effects of acute ingestion of caffeine on short-duration high intensity performance are equivocal, while studies of novel modes of delivery and the efficacy of low doses of caffeine are warranted. The aims of the present study were to investigate the effect of acute ingestion of caffeinated chewing gum on repeated sprint performance (RSP) in team sport athletes, and whether habitual caffeine consumption alters the ergogenic effect, if any, on RSP. Eighteen male team sports athletes undertook four RSP trials using a 40 m maximum shuttle run test (MST), which incorporates 10x40 m sprints with 30 s between the start of each sprint...
November 1, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29091469/case-study-dose-response-of-caffeine-on-20-km-handcycling-time-trial-performance-in-a-para-triathlete
#11
Terri Graham-Paulson, Claudio Perret, Victoria Goosey-Tolfrey
Caffeine's ability to influence upper-body exercise (UBE) endurance performance may be related to an individual's training status. This case study therefore aimed to investigate the ergogenic effects of caffeine dose on 20 km time trial (TT) performance of an elite male Para-triathlete (wheelchair user) (age 46 y, body mass 76.9 kg, body fat 25.4%, handcycling V̇O2peak 3.45 l·min(-1)). The athlete completed four 20 km handcycling TT's on a Cyclus II ergometer under laboratory controlled conditions following the ingestion of 2, 4 and 6 mg·kg(-1) caffeine (CAF) or placebo (PLA)...
November 1, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29072170/caffeine-intake-and-abstract-reasoning-among-1374-unselected-men-and-women-from-general-population-role-of-the-163c-a-polymorphism-of-cyp1a2-gene
#12
Edoardo Casiglia, Valérie Tikhonoff, Federica Albertini, Jacopo Favaro, Martina Montagnana, Elisa Danese, Francesco Finatti, Marco Benati, Alberto Mazza, Lucia Dal Maso, Paolo Spinella, Paolo Palatini
BACKGROUND AND AIMS: The possible effect of caffeine as an enhancer of cognitive performance, particularly that on abstract reasoning, has never been studied in an epidemiological setting, especially in relation to -163C>A polymorphism of CYP1A2 gene, largely controlling caffeine metabolism. Aim of this study was to ascertain whether in general population free chronic caffeine intake modifies abstract reasoning, and if this effect is influenced by the above mentioned genotype, by age, schooling, ethanol intake and smoking habits...
August 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29067490/derivation-of-some-contemporary-scales-to-measure-adolescent-risk-taking-in-canada
#13
Jonathan L Kwong, Don A Klinger, Ian Janssen, William Pickett
OBJECTIVES: To derive a contemporary series of composite indicators of adolescent risk-taking, inspired by the US CDC Framework and Problem Behaviour Theory. METHODS: Factor analyses were performed on 28-risk behaviours in a nationally representative sample of 30,096 Grades 6-10 students from the 2014 Canadian Health Behaviour in School-aged Children study. RESULTS: Three composite indicators emerged from our analysis: (1) Overt Risk-Taking (i...
October 25, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/29065278/the-effects-of-low-and-moderate-dose-caffeine-supplementation-on-upper-and-lower-body-maximal-voluntary-concentric-and-eccentric-muscle-force
#14
Jason Tallis, Harley C M Yavuz
Despite the growing quantity of literature exploring the effect of caffeine on muscular strength, there is a dearth of data that directly explores differences in erogenicity between upper and lower body musculature and the dose response effect. The present study sought to investigate the effects of low and moderate dose caffeine on the maximal voluntary strength of the elbow flexors and knee extensors. Ten non-specifically strength trained, recreationally active participants (21 ± 0.3 yrs) completed the study...
October 24, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29065052/energy-drink-doses-of-caffeine-and-taurine-have-a-null-or-negative-effect-on-sprint-performance
#15
Owen Jeffries, Jessica Hill, Stephen D Patterson, Mark Waldron
This study investigated the effects of caffeine and taurine co-ingestion on repeat-sprint cycling performance and associated physiological and perceptual responses. In a double blind, cross-over, repeated measures study, 11 male participants (age 21 ± 2 years; stature 178 ± 7 cm; body mass 80 ± 13 kg) completed 10 x 6-s sprints on a cycle ergometer, each separated by 24-s, an hour after ingesting: caffeine (80 mg) and taurine (1 g), equivalent to the amount observed in popular commercial energy drinks, or placebo (maltodextrin ∼1 g) in a gelatine capsule...
October 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29063606/harnessing-meta-analysis-to-refine-an-oncology-patient-population-for-physiology-based-pharmacokinetic-modeling-of-drugs
#16
Emily Schwenger, Venkatesh Pilla Reddy, Ganesh Moorthy, Pradeep Sharma, Helen Tomkinson, Eric Masson, Karthick Vishwanathan
Certain oncology compounds exhibit fundamental PK disparities between healthy and malignant conditions. Given the effects of tumor-associated inflammation on enzyme and transporter expression, we performed a meta-analysis of CYP- and transporter-sensitive substrate clinical PK to quantitatively compare enzyme and transporter abundances between healthy volunteers (HV) and cancer patients (CP). Hepatic and intestinal CYP1A2, CYP2C19, and CYP3A4 abundance were subsequently adjusted via Simcyp®'s sensitivity analysis tool...
October 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29061705/polyphenol-and-caffeine-rich-post-fermented-pu-er-tea-improves-diet-induced-metabolic-syndrome-by-remodeling-intestinal-homeostasis-in-mice
#17
Xiaoyu Gao, Qiuhong Xie, Ping Kong, Ling Liu, Sheng Sun, Boyu Xiong, Baojia Huang, Liang Yan, Jun Sheng, Hongyu Xiang
Post-fermented Pu-er tea (PE) protects against metabolic syndrome (MS), but little is known regarding its underlying mechanisms. Animal experiments were performed to determine whether gut microbiota mediated the improvement in diet-induced MS by PE and its main active components (PEAC). We confirmed that PE altered the body composition and energy efficiency; attenuated metabolic endotoxemia and systemic and multiple-tissue inflammation; and improved the glucose and lipid metabolism disorder in high-fat diet (HFD)-fed mice via multiple pathways...
October 23, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29055953/an-open-label-randomized-multicenter-study-assessing-the-noninferiority-of-a-caffeine-based-topical-liquid-0-2-versus-minoxidil-5-solution-in-male-androgenetic-alopecia
#18
Rachita Dhurat, Jill Chitallia, Theodor W May, Ammani M Jayaraaman, Jithendriya Madhukara, Subbu Anandan, Pradyumna Vaidya, Adolf Klenk
BACKGROUND: Androgenetic alopecia is a condition with a high prevalence worldwide and affects both males and females. Currently, only 2 approved treatments exist: finasteride (males only) and minoxidil 2 or 5% solution (males and females). METHODS: We conducted a randomized, open-label, multicenter noninferiority study to determine whether a caffeine-based 0.2% topical liquid would be no less effective than minoxidil 5% solution in males (n = 210) with androgenetic alopecia...
October 21, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29049076/fatigue-risk-management-the-impact-of-anesthesiology-residents-work-schedules-on-job-performance-and-a-review-of-potential-countermeasures
#19
Lily R Wong, Erin Flynn-Evans, Keith J Ruskin
Long duty periods and overnight call shifts impair physicians' performance on measures of vigilance, psychomotor functioning, alertness, and mood. Anesthesiology residents typically work between 64 and 70 hours per week and are often required to work 24 hours or overnight shifts, sometimes taking call every third night. Mitigating the effects of sleep loss, circadian misalignment, and sleep inertia requires an understanding of the relationship among work schedules, fatigue, and job performance. This article reviews the current Accreditation Council for Graduate Medical Education guidelines for resident duty hours, examines how anesthesiologists' work schedules can affect job performance, and discusses the ramifications of overnight and prolonged duty hours on patient safety and resident well-being...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29042830/evaluation-of-the-effects-of-two-doses-of-alpha-glycerylphosphorylcholine-on-physical-and-psychomotor-performance
#20
Lena Marcus, Jason Soileau, Lawrence W Judge, David Bellar
BACKGROUND: Recent studies have suggested that alpha glycerylphosphorylcholine (A-GPC) may be an effective ergogenic aid. The present study was designed to assess the efficacy of two doses of A-GPC in comparison to placebo and caffeine for increasing countermovement jump performance, isometric strength, and psychomotor function. METHODS: Forty-eight healthy, college aged males volunteered for the present study and underwent baseline assessment of countermovement jump (CMJ), isometric mid thigh pull (IMTP), upper body isometric strength test (UBIST), and psychomotor vigilance (PVT)...
2017: Journal of the International Society of Sports Nutrition
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