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caffeine and performance

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https://www.readbyqxmd.com/read/27898032/the-antiproliferative-effect-of-chakasaponins-i-and-ii-floratheasaponin-a-and-epigallocatechin-3-o-gallate-isolated-from-camellia-sinensis-on-human-digestive-tract-carcinoma-cell-lines
#1
Niichiro Kitagawa, Toshio Morikawa, Chiaki Motai, Kiyofumi Ninomiya, Shuhei Okugawa, Ayaka Nishida, Masayuki Yoshikawa, Osamu Muraoka
Acylated oleanane-type triterpene saponins, namely chakasaponins I (1) and II (2), floratheasaponin A (3), and their analogs, together with catechins-including (-)-epigallocatechin 3-O-gallate (4), flavonoids, and caffeine-have been isolated as characteristic functional constituents from the extracts of "tea flower", the flower buds of Camellia sinensis (Theaceae), which have common components with that of the leaf part. These isolates exhibited antiproliferative activities against human digestive tract carcinoma HSC-2, HSC-4, MKN-45, and Caco-2 cells...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27895607/caffeine-enhances-memory-performance-in-young-adults-during-their-non-optimal-time-of-day
#2
Stephanie M Sherman, Timothy P Buckley, Elsa Baena, Lee Ryan
Many college students struggle to perform well on exams in the early morning. Although students drink caffeinated beverages to feel more awake, it is unclear whether these actually improve performance. After consuming coffee (caffeinated or decaffeinated), college-age adults completed implicit and explicit memory tasks in the early morning and late afternoon (Experiment 1). During the morning, participants ingesting caffeine demonstrated a striking improvement in explicit memory, but not implicit memory. Caffeine did not alter memory performance in the afternoon...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27894020/the-anatomical-mummies-of-mombello-detection-of-cocaine-nicotine-and-caffeine-in-the-hair-of-psychiatric-patients-of-the-early-20th-century
#3
Frank Musshoff, Helena Fels, Alberto Carli, Dario Piombino-Mascali
The Mombello Psychiatric Hospital in Limbiate, near Milan, replaced the old Senavra Hospital as the Psychiatric Hospital for the Province of Milan in the 19th century. During the early 20th century, bodies of several Mombello patients were dissected and preserved by Giuseppe Paravicini, an anatomist who operated within the asylum. The aim of the present study was to examine and memorialize this important assemblage. To this end, we were allowed to sample the head hair of six such preparations for toxicological analysis...
November 14, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27891166/relation-of-24-hour-urinary-caffeine-and-caffeine-metabolite-excretions-with-self-reported-consumption-of-coffee-and-other-caffeinated-beverages-in-the-general-population
#4
Dusan Petrovic, Sandrine Estoppey Younes, Menno Pruijm, Belén Ponte, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Markus Mohaupt, Fred Paccaud, Bruno Vogt, Antoinette Pechère-Bertschi, Pierre-Yves Martin, Michel Burnier, Chin B Eap, Murielle Bochud, Idris Guessous
BACKGROUND: Caffeine intake is generally estimated by self-reported consumption, but it remains unclear how well self-report associates with metabolite urinary excretion. We investigated the associations of self-reported consumption of caffeinated drinks with urinary excretion of caffeine and its major metabolites in an adult population. METHODS: We used data from the population-based Swiss Kidney Project on Genes in Hypertension (SKIPOGH) study. Consumption of caffeinated coffee, decaffeinated coffee and other caffeinated beverages was assessed by self-administered questionnaire...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27889114/the-hidden-web-and-the-fentanyl-problem-detection-of-ocfentanil-as-an-adulterant-in-heroin
#5
Pol Quintana, Mireia Ventura, Marc Grifell, Alvaro Palma, Liliana Galindo, Iván Fornís, Cristina Gil, Xoán Carbón, Fernando Caudevilla, Magí Farré, Marta Torrens
BACKGROUND: The popularization of anonymous markets such as Silk Road is challenging current drug policy and may provide a new context for old issues, such as adulteration of heroin with fentanyl derivatives. The aims of this paper are to report the presence of ocfentanil, a novel, potent, non-controlled fentanyl analog, in samples sold as heroin in the hidden web, and to summarize the effects reported by users. METHODS: In 2015, four samples allegedly bought as heroin in cryptomarkets of the hidden web were sent to Energy Control for analysis...
November 23, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27882605/placebo-in-sports-nutrition-a-proof-of-principle-study-involving-caffeine-supplementation
#6
B Saunders, L F de Oliveira, R P da Silva, V de Salles Painelli, L S Gonçalves, G Yamaguchi, T Mutti, E Maciel, H Roschel, G G Artioli, B Gualano
We investigated the effects of supplement identification on exercise performance with caffeine supplementation. Forty-two trained cyclists (age 37 ± 8 years, body mass [BM] 74.3 ± 8.4 kg, height 1.76 ± 0.06 m, maximum oxygen uptake 50.0 ± 6.8 mL/kg/min) performed a ~30 min cycling time-trial 1 h following either 6 mg/kgBM caffeine (CAF) or placebo (PLA) supplementation and one control (CON) session without supplementation. Participants identified which supplement they believed they had ingested ("caffeine", "placebo", "don't know") pre- and post-exercise...
November 23, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27867329/caffeine-as-a-probable-factor-for-increased-risk-of-oab-development-in-elderly-people
#7
Kirill V Kosilov, Sergay A Loparev, Marina A Ivanovskaya, Liliya V Kosilova
OBJECTIVE: This study was conducted to compare overactive bladder (OAB) prevalence among people greater than 60 years of age who intake various doses of caffeine, as well as those who abstain from caffeine. PATIENTS AND METHODS: A randomized observational study was carried out in Vladivostok Gerontological Hospital. A total of 1,098 retired people greater than 60 years of age (659 women and 439 men, average age 67.1 years) took part in the study. They were admitted to the in-patient department with the purpose of annual physical examination performed in accordance with the order of the Ministry of Public Health of the Russian Federation...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27864843/measurement-of-caffeine-and-its-three-primary-metabolites-in-human-plasma-by-hplc-esi-ms-ms-and-clinical-application
#8
Feng Chen, Zhe-Yi Hu, Robert B Parker, S Casey Laizure
Caffeine is a mild stimulant with significant potential for abuse being consumed in larger doses with the widespread availability of energy drinks and by novel routes of administration such as inspired powder, oral sprays, and electronic cigarettes. How these recent changes in caffeine consumption affecting caffeine disposition and abuse potential is of growing concern. In the study of caffeine disposition in humans, it is common to only measure the caffeine concentration; however, caffeine's three major metabolites (paraxanthine, theobromine, and theophylline) retain central nervous system stimulant activity that may contribute to the overall pharmacological activity and toxicity...
November 18, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27864638/effects-of-caffeine-on-neuromuscular-fatigue-and-performance-during-high-intensity-cycling%C3%A2-exercise-in-moderate-hypoxia
#9
Bruno P C Smirmaul, Antonio Carlos de Moraes, Luca Angius, Samuele M Marcora
PURPOSE: To investigate the effects of caffeine on performance, neuromuscular fatigue and perception of effort during high-intensity cycling exercise in moderate hypoxia. METHODS: Seven adult male participants firstly underwent an incremental exercise test on a cycle ergometer in conditions of acute normobaric hypoxia (fraction inspired oxygen = 0.15) to establish peak power output (PPO). In the following two visits, they performed a time to exhaustion test (78 ± 3% PPO) in the same hypoxic conditions after caffeine ingestion (4 mg kg(-1)) and one after placebo ingestion in a double-blind, randomized, counterbalanced cross-over design...
November 18, 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27856103/determination-of-pharmaceutical-residues-in-wastewater-using-high-performance-liquid-chromatography-coupled-to-quadrupole-orbitrap-mass-spectrometry
#10
Iveta Pugajeva, Janis Rusko, Ingus Perkons, Elsa Lundanes, Vadims Bartkevics
A multi-class method for the determination of 24 emerging pharmaceutical residues has been developed and validated. The method is based on solid-phase extraction of wastewater samples using Strata-X cartridges followed by high performance liquid chromatography coupled to hybrid quadrupole - Orbitrap high resolution mass spectrometry (HPLC-Q-Orbitrap-HRMS). A single-laboratory validation procedure showed satisfactory analytical performance. The analysis of 21 samples collected at the wastewater treatment plant in Riga revealed the occurrence of 20 compounds of different therapeutic classes...
January 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27842485/cytochrome-p450-2a6-phenotyping-using-dietary-caffeine-salivary-metabolite-ratios-and-genotyping-using-blood-on-storage-cards-in-non-smoking-japanese-volunteers
#11
Norie Murayama, Makiko Shimizu, Kenta KObayashi, Izumi KIshimoto, Hiroshi Yamazaki
BACKGROUND: A simple method of genotyping and phenotyping cytochrome P450 2A6 (CYP2A6) was previously reported using individual blood samples and urinary caffeine metabolite ratios of 1,7-dimethyluric acid (17U) to 1-methylxanthine (1X). OBJECTIVE: Blood spotted onto storage cards and salivary caffeine metabolites were analyzed in 27 healthy non-smoking Japanese volunteers with no prior abstention from dietary caffeine intake. METHODS: 1,7-Dimethylxanthine (17X), 17U, 1X, and caffeine levels in spot saliva samples were determined in Japanese non-smokers by high-performance liquid chromatography under normal dietary caffeine consumption...
November 14, 2016: Drug Metabolism Letters
https://www.readbyqxmd.com/read/27837362/occurrence-and-seasonal-variations-of-25-pharmaceutical-residues-in-wastewater-and-drinking-water-treatment-plants
#12
A Kot-Wasik, A Jakimska, M Śliwka-Kaszyńska
Thousands of tons of pharmaceuticals are introduced into the aqueous environment due to their incomplete elimination during treatment process in wastewater treatment plants (WWTPs) and water treatment plants (WTPs). The presence of pharmacologically active compounds in the environment is of a great interest because of their potential to cause negative effects. Furthermore, drugs can undergo different processes leading to the formation of new transformation products, which may be more toxic than the parent compound...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27833051/theobromine-up-regulates-cerebral-brain-derived-neurotrophic-factor-and-facilitates-motor-learning-in-mice
#13
Mitsugu Yoneda, Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Hayate Tanigami, Akihiro Yachie, Takako Ohno-Shosaku, Osamu Shido
Theobromine, which is a caffeine derivative, is the primary methylxanthine produced by Theobroma cacao. Theobromine works as a phosphodiesterase (PDE) inhibitor to increase intracellular cyclic adenosine monophosphate (cAMP). cAMP activates the cAMP-response element-binding protein (CREB), which is involved in a large variety of brain processes, including the induction of the brain-derived neurotrophic factor (BDNF). BDNF supports cell survival and neuronal functions, including learning and memory. Thus, cAMP/CREB/BDNF pathways play an important role in learning and memory...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27825683/the-distribution-dynamics-and-desorption-behaviour-of-mobile-pharmaceuticals-and-caffeine-to-combined-sewer-sediments
#14
M Hajj-Mohamad, H Darwano, S Vo Duy, S Sauvé, M Prévost, H P H Arp, S Dorner
Pharmaceuticals are discharged to the environment from wastewater resource recovery facilities, sewer overflows, and illicit sewer connections. To understand the fate of pharmaceuticals, there is a need to better understand their sorption dynamics to suspended sediments (SS) and settled sediments (StS) in sewer systems. In this study, such sorption dynamics to both SS and StS were assessed using a batch equilibrium method under both static and dynamic conditions. Experiments were performed with natively occurring and artificially modified concentrations of sewer pharmaceuticals (acetaminophen, theophylline, carbamazepine, and a metabolite of carbamazepine) and caffeine...
October 24, 2016: Water Research
https://www.readbyqxmd.com/read/27821197/the-association-between-pro-arrhythmic-agents-and-aortic-stenosis-in-young-adults-is-it-sufficient-to-clarify-the-sudden-unexpected-deaths
#15
Bojana Radnic, Nemanja Radojevic, Jelena Vucinic, Natasa Duborija-Kovacevic
Most young patients with mild-to-moderate aortic stenosis show no symptoms, and sudden death appears only occasionally. We hypothesised that malignant ventricular arrhythmias could be responsible for the high incidence of sudden death in such patients. If multiple factors such as asymptomatic aortic stenosis in association with arrhythmia-provoking agents are involved, could it be sufficient to account for sudden unexpected death? In this study, eight cases of sudden death in young adults, with ages ranging from 22 to 36 years, who had never reported any symptoms that could be related to aortic stenosis, were investigated...
November 8, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27819409/interventions-for-chronic-kidney-disease-associated-restless-legs-syndrome
#16
REVIEW
Seerapani Gopaluni, Mohamed Sherif, Naim A Ahmadouk
BACKGROUND: Restless legs syndrome (RLS) is defined as the spontaneous movement of the limbs (mainly legs) associated with unpleasant, sometimes painful sensation which is relieved by moving the affected limb. Prevalence of RLS among people on dialysis has been estimated between 6.6% and 80%. RLS symptoms contribute to impaired quality of life and people with RLS are shown to have increased cardiovascular morbidity and mortality.Various pharmacological and non-pharmacological interventions have been used to treat primary RLS...
November 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27818712/integrated-electrodes-and-electrospray-emitter-for-polymer-microfluidic-nanospray-ms-interface
#17
Anna V Forzano, Vedada Becirovic, R Scott Martin, James L Edwards
Interfacing of microfluidic devices to mass spectrometry has challenges including dilution from sheath liquid junctions, fragile electrodes, and excessive dead volumes which prevent optimum performance and common use. The goal of this work is to develop a stable nanospray chip-MS interface that contains easily integrated electrodes and an embedded capillary emitter to mitigate current chip-MS problems. This system uses a hybrid polystyrene-poly(dimethylsiloxane) (PS-PDMS) microfluidic platform with an embedded electrode and integrated capillary emitter used as the nanospray interface...
July 7, 2016: Analytical Methods: Advancing Methods and Applications
https://www.readbyqxmd.com/read/27818322/an-overview-of-herb-and-dietary-supplement-efficacy-safety-and-government-regulations-in-the-united-states-with-suggested-improvements-part-1-of-5-series
#18
REVIEW
Amy Christine Brown
This is the first of five review articles investigating dietary supplements (DS; includes herbs) that now exceed over 50,000 in the Office of Dietary Supplement's "Dietary Supplement Label Database." Four review articles follow summarizing published medical case reports of DS related to liver toxicity, kidney toxicity, heart toxicity, and cancer. The most popular DS were vitamin or mineral supplements (43%) followed by specialty supplements (20%), botanicals (herbs; 20%), and sports supplements (16%). The 2013 Annual Report of the American Association of Poison Control Centers revealed 1692 fatalities due to drugs and zero deaths due to DS...
November 3, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27803179/physicians-attentional-performance-following-a-24-hour-observation-period-do-we-need-to-regulate-sleep-prior-to-work
#19
P Smyth, K Maximova, J D Jirsch
BACKGROUND: The tradition of physicians working while sleep deprived is increasingly criticised. Medical regulatory bodies have restricted resident physician duty-hours, not addressing the greater population of physicians. We aimed to assess factors such as sleep duration prior to a 24-hour observation period on physicians' attention. METHODS: We studied 70 physicians (mean age 38 years old (SD 10.8 years)): 36 residents and 34 faculty from call rosters at the University of Alberta...
November 1, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27802855/a-remarkable-case-of-rhabdomyolysis-associated-with-ingestion-of-energy-drink-neon-volt
#20
Praneet S Iyer, Rishitha Yelisetti, Varun Miriyala, Waqas Siddiqui, Anand Kaji
Rhabdomyolysis is defined as a syndrome characterized by muscle necrosis and the release of intracellular muscle constituents into the circulation. We present a case of a 35-year-old male who exercised for 2 h after ingesting energy drink and subsequently presented with rhabdomyolysis. After excluding common and uncommon causes of rhabdomyolysis, we reached the conclusion that the likely cause was the ingestion of energy drink 'NEON VOLT' in a setting of mild dehydration. Increasing physical activity and intense exercise is becoming a trend in many countries, due to its many health-related benefits such as prevention of obesity...
2016: Journal of Community Hospital Internal Medicine Perspectives
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