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Mcgovern report

L Williams, E McGovern, O Kimmich, A Molloy, I Beiser, J S Butler, F Molloy, P Logan, D G Healy, T Lynch, R Walsh, L Cassidy, P Moriarty, H Moore, T McSwiney, C Walsh, S O'Riordan, M Hutchinson
BACKGROUND: Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder. AIM: To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland. METHODS: Patients with adult onset idiopathic isolated focal dystonia were recruited from multiple sources...
September 19, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Robert J Fox, Christopher S Coffey, Merit E Cudkowicz, Trevis Gleason, Andrew Goodman, Eric C Klawiter, Kazuko Matsuda, Michelle McGovern, Robin Conwit, Robert Naismith, Akshata Ashokkumar, Robert Bermel, Dixie Ecklund, Maxine Koepp, Jeffrey Long, Sneha Natarajan, Srividya Ramachandran, Thomai Skaramagas, Brenda Thornell, Jon Yankey, Mark Agius, Khurram Bashir, Bruce Cohen, Patricia Coyle, Silvia Delgado, Dana Dewitt, Angela Flores, Barbara Giesser, Myla Goldman, Burk Jubelt, Neil Lava, Sharon Lynch, Augusto Miravalle, Harold Moses, Daniel Ontaneda, Jai Perumal, Michael Racke, Pavle Repovic, Claire Riley, Christopher Severson, Shlomo Shinnar, Valerie Suski, Bianca Weinstock-Gutman, Vijayshree Yadav, Aram Zabeti
BACKGROUND: Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS), is characterized by gradual progression of disability. The current anti-inflammatory treatments for MS have little or no efficacy in PMS in the absence of obvious active inflammation. Optimal biomarkers for phase II PMS trials is unknown. Ibudilast is an inhibitor of macrophage migration inhibitor factor and phosphodiesterases-4 and -10 and exhibits possible neuroprotective properties...
September 2016: Contemporary Clinical Trials
Anthony L Guerrerio, Pamela A Frischmeyer-Guerrerio, Chengrui Huang, Yuqiong Wu, Talin Haritunians, Dermot P B McGovern, Gretchen L MacCarrick, Steven R Brant, Harry C Dietz
BACKGROUND: TGFβ is a multifunctional cytokine that is critical in regulating mucosal immunity. Murine studies have revealed that disruption of canonical TGFβ signaling leads to systemic inflammation including colitis. Loeys-Dietz syndrome (LDS) results from heterozygous mutations in the genes encoding the subunits of the TGFβ receptor. METHODS: All patients with confirmed mutations in TGFBR1 or TGFBR2, seen in the Johns Hopkins Connective Tissue Disorders clinic, were asked to participate in the study...
September 2016: Inflammatory Bowel Diseases
Martin Reuter, Christian Montag, Steffen Altmann, Fabian Bendlow, Christian Elger, Peter Kirsch, Albert Becker, Susanne Schoch-McGovern, Matthias Simon, Bernd Weber, Andrea Felten
The oxytocin system plays a prominent role in social behaviour across species, and numerous genetic studies in humans have reported associations between polymorphisms on the oxytocin receptor gene (OXTR) and phenotypes related to social cognition, affiliation, perspective taking and sociability in healthy subjects and in patients with atypical social behaviour, such as in autistic spectrum disorders (ASD). Recently, the first study demonstrating altered agonist-induced OXTR internalization and recycling for the exonic variant rs35062132 emerged...
July 15, 2016: Social Neuroscience
Rona M Barron, Declan King, Martin Jeffrey, Gillian McGovern, Sonya Agarwal, Andrew C Gill, Pedro Piccardo
Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy (TSE) has been described following inoculation and passage of various forms of fibrils in transgenic mice and hamsters...
October 2016: Acta Neuropathologica
Werner Scheithauer, Ramesh K Ramanathan, Malcolm Moore, Teresa Macarulla, David Goldstein, Pascal Hammel, Volker Kunzmann, Helen Liu, Desmond McGovern, Alfredo Romano, Daniel D Von Hoff
BACKGROUND: Dose modifications following adverse events (AEs) are an important part of the management of patients with pancreatic cancer treated with chemotherapy. While dose modifications are utilized to ensure patient safety, the subsequent influence of dose adjustments on treatment exposure and efficacy have not been reported in detail. This exploratory analysis examined the influence of dose modifications on treatment exposure and efficacy in the phase III MPACT trial, which demonstrated superior efficacy of nab-paclitaxel (nab-P) plus gemcitabine (Gem) to Gem alone for the treatment of metastatic pancreatic cancer...
June 2016: Journal of Gastrointestinal Oncology
T M Richards, S A Bhide, A B Miah, L Del Rosario, S Bodla, K Thway, D M Gujral, K P Rooney, U Schick, T McGovern, L Grove, K L Newbold, K J Harrington, C M Nutting
AIMS: To determine the clinical outcomes of an intensity-modulated radiotherapy technique for total mucosal irradiation (TM-IMRT) in patients with head and neck carcinoma of unknown primary (HNCUP). MATERIALS AND METHODS: A single-centre prospective phase II trial design was used in two sequential studies to evaluate TM-IMRT for HNCUP. Patients were investigated for primary tumour site using examination under anaesthetic and biopsies, computed tomography ± magnetic resonance imaging (MRI) or 18-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT)...
September 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Ali H Mokdad, Mohammad Hossein Forouzanfar, Farah Daoud, Arwa A Mokdad, Charbel El Bcheraoui, Maziar Moradi-Lakeh, Hmwe Hmwe Kyu, Ryan M Barber, Joseph Wagner, Kelly Cercy, Hannah Kravitz, Megan Coggeshall, Adrienne Chew, Kevin F O'Rourke, Caitlyn Steiner, Marwa Tuffaha, Raghid Charara, Essam Abdullah Al-Ghamdi, Yaser Adi, Rima A Afifi, Hanan Alahmadi, Fadia AlBuhairan, Nicholas Allen, Mohammad AlMazroa, Abdulwahab A Al-Nehmi, Zulfa AlRayess, Monika Arora, Peter Azzopardi, Carmen Barroso, Mohammed Basulaiman, Zulfiqar A Bhutta, Chris Bonell, Cecilia Breinbauer, Louisa Degenhardt, Donna Denno, Jing Fang, Adesegun Fatusi, Andrea B Feigl, Ritsuko Kakuma, Nadim Karam, Elissa Kennedy, Tawfik A M Khoja, Fadi Maalouf, Carla Makhlouf Obermeyer, Amitabh Mattoo, Terry McGovern, Ziad A Memish, George A Mensah, Vikram Patel, Suzanne Petroni, Nicola Reavley, Diego Rios Zertuche, Mohammad Saeedi, John Santelli, Susan M Sawyer, Fred Ssewamala, Kikelomo Taiwo, Muhammad Tantawy, Russell M Viner, Jane Waldfogel, Maria Paola Zuñiga, Mohsen Naghavi, Haidong Wang, Theo Vos, Alan D Lopez, Abdullah A Al Rabeeah, George C Patton, Christopher J L Murray
BACKGROUND: Young people's health has emerged as a neglected yet pressing issue in global development. Changing patterns of young people's health have the potential to undermine future population health as well as global economic development unless timely and effective strategies are put into place. We report the past, present, and anticipated burden of disease in young people aged 10-24 years from 1990 to 2013 using data on mortality, disability, injuries, and health risk factors. METHODS: The Global Burden of Disease Study 2013 (GBD 2013) includes annual assessments for 188 countries from 1990 to 2013, covering 306 diseases and injuries, 1233 sequelae, and 79 risk factors...
June 11, 2016: Lancet
Dalin Li, Mark S Silverberg, Talin Haritunians, Marla C Dubinsky, Carol Landers, Joanne M Stempak, Raquel Milgrom, Xiuqing Guo, Yii-Der Ida Chen, Jerome I Rotter, Kent D Taylor, Dermot P B McGovern, Stephan R Targan
The genetic basis of antineutrophil cytoplasmic antibody, an important biomarker of inflammatory bowel disease (IBD), has never been thoroughly examined on a genome-wide scale. In this study, we performed a 2-stage genome-wide association study (GWAS) on antineutrophil cytoplasmic antibody in IBD cases. In the 2959 IBD cases in the discovery stage, we observed an association between a variant in the gene TNFRSF1B with antineutrophil cytoplasmic antibody level (rs5745994, minor allele frequency = 0.028, beta = 18...
June 2016: Inflammatory Bowel Diseases
Jordan F Karp, Jonathan McGovern, Megan M Marron, Peter Gerszten, Debra K Weiner, David Okonkwo, Adam S Kanter
AIM: To improve selection of older lumbar surgical candidates, we surveyed correlates of functioning and satisfaction with surgery. MATERIALS & METHODS: Prospective sample at lumbar spine surgery clinic. Patients (n = 48) were evaluated before surgery and after 3 months. Dependent variables were functioning and surgical satisfaction. RESULTS: Baseline variables associated with disability at 3 months included cognitive status and widespread pain...
April 22, 2016: Pain Management
Bernadette Mazurek Melnyk, Caitlin Slevin, Lisa Militello, Jacqueline Hoying, Alice Teall, Colleen McGovern
BACKGROUND AND PURPOSE: Little is known about the physical health, lifestyle beliefs and behaviors, and mental health among first-year health professional graduate students. Therefore, the purpose of this study was to describe these attributes as well as to explore the relationships among them. METHODS: A descriptive correlational study was conducted on the baseline data from a wellness onboarding intervention study with 93 health sciences students from seven different colleges within a large public land grant university in the Midwest United States...
April 2016: Journal of the American Association of Nurse Practitioners
Manreet Kaur, Deepa Panikkath, Xiaofei Yan, Zhenqiu Liu, Dror Berel, Dalin Li, Eric A Vasiliauskas, Andrew Ippoliti, Marla Dubinsky, David Q Shih, Gil Y Melmed, Talin Haritunians, Phillip Fleshner, Stephan R Targan, Dermot P B McGovern
BACKGROUND: Perianal Crohn's Disease (pCD) is a particularly severe phenotype associated with poor quality of life with a reported prevalence of 12%-40%. Previous studies investigating the etiology of pCD have been limited in the numbers of subjects and the intensity of genotyping. The aim of this study was to identify clinical, serological, and genetic factors associated with pCD. METHODS: We performed a case-control study comparing patients with (pCD+) and without perianal (pCD) involvement in CD; defined as the presence of perianal abscesses or fistulae...
April 2016: Inflammatory Bowel Diseases
Benjamin R Nordstrom, Elizabeth C Saunders, Bethany McLeman, Andrea Meier, Haiyi Xie, Chantal Lambert-Harris, Beth Tanzman, John Brooklyn, Gregory King, Nels Kloster, Clifton Frederick Lord, William Roberts, Mark P McGovern
OBJECTIVES: Rapidly escalating rates of heroin and prescription opioid use have been widely observed in rural areas across the United States. Although US Food and Drug Administration-approved medications for opioid use disorders exist, they are not routinely accessible to patients. One medication, buprenorphine, can be prescribed by waivered physicians in office-based practice settings, but practice patterns vary widely. This study explored the use of a learning collaborative method to improve the provision of buprenorphine in the state of Vermont...
March 2016: Journal of Addiction Medicine
E G Chiorean, D D Von Hoff, M Reni, F P Arena, J R Infante, V G Bathini, T E Wood, P N Mainwaring, R T Muldoon, P R Clingan, V Kunzmann, R K Ramanathan, J Tabernero, D Goldstein, D McGovern, B Lu, A Ko
BACKGROUND: A phase I/II study and subsequent phase III study (MPACT) reported significant correlations between CA19-9 decreases and prolonged overall survival (OS) with nab-paclitaxel plus gemcitabine (nab-P + Gem) treatment for metastatic pancreatic cancer (MPC). CA19-9 changes at week 8 and potential associations with efficacy were investigated as part of an exploratory analysis in the MPACT trial. PATIENTS AND METHODS: Untreated patients with MPC (N = 861) received nab-P + Gem or Gem alone...
April 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
David Kulak, Sangita K Jindal, Cheongeun Oh, Sara S Morelli, Scott Kratka, Peter G McGovern
OBJECTIVE: To assess the relationship between live birth rates (LBRs) and the incidence of under-reported cycles by IVF clinics. DESIGN: Cohort study. SETTING: Not applicable. PATIENT(S): All patients undergoing IVF cycles in the aforementioned clinics. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): The reporting percentage (RP), defined as number of cycles with reported pregnancy rates divided by total cycles performed...
April 2016: Fertility and Sterility
A P McGovern, H Fieldhouse, Z Tippu, S Jones, N Munro, S de Lusignan
AIMS: To describe the proportion of glucose tests with unrecorded provenance in routine primary care data and identify the impact on clinical practice. METHODS: A cross-sectional analysis was conducted of blood glucose measurements from the Royal College of General Practitioner Research and Surveillance Centre database, which includes primary care records from >100 practices across England and Wales. All blood glucose results recorded during 2013 were identified...
January 16, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
Jacob J van den Berg, Mary B Roberts, Beth C Bock, Rosemarie A Martin, L A R Stein, Donna R Parker, Arthur R McGovern, Sarah Hart Shuford, Jennifer G Clarke
Prior research has found high levels of depression and stress among persons who are incarcerated in the United States (U.S.). However, little is known about changes in depression and stress levels among inmates post-incarceration. The aim of this study was to examine changes in levels of depression and stress during and after incarceration in a tobacco-free facility. Questionnaires that included valid and reliable measures of depression and stress were completed by 208 male and female inmates approximately eight weeks before and three weeks after release from a northeastern U...
January 2016: International Journal of Environmental Research and Public Health
Jelal Alsubai, Gail L Matters, Christopher O McGovern, Jiangang Liao, Evan L Gilius, Jill P Smith
OBJECTIVES: Today, genetic biomarkers have been demonstrated to play an important role in identifying at-risk subjects for familial or inherited cancers. We have identified a single-nucleotide polymorphism (SNP) that results in missplicing of the cholecystokinin (CCK) receptor gene and expressing a larger mutated receptor in pancreatic cancer. The purpose of this study was to evaluate the significance and specificity of this SNP as a potential biomarker in patients with pancreatic cancer compared with other gastrointestinal (GI) cancers that also have CCK receptors...
2016: Clinical and Translational Gastroenterology
W Arnold, Vicki L McGovern, Benjamin Sanchez, Jia Li, Kaitlyn M Corlett, Stephen J Kolb, Seward B Rutkove, Arthur H Burghes
BACKGROUND: Significant advances in the development of SMN-restoring therapeutics have occurred since 2010 when very effective biological treatments were reported in mouse models of spinal muscular atrophy. As these treatments are applied in human clinical trials, there is pressing need to define quantitative assessments of disease progression, treatment stratification, and therapeutic efficacy. The electrophysiological measures Compound Muscle Action Potential and Motor Unit Number Estimation are reliable measures of nerve function...
March 2016: Neurobiology of Disease
John S Butler, Ines M Beiser, Laura Williams, Eavan McGovern, Fiona Molloy, Tim Lynch, Dan G Healy, Helena Moore, Richard Walsh, Richard B Reilly, Seán O'Riordan, Cathal Walsh, Michael Hutchinson
BACKGROUND: Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participants. OBJECTIVES: We assessed the distinctive features of age-related sexual dimorphism of (i) sex ratios in dystonia phenotypes and (ii) sexual dimorphism in temporal discrimination in unaffected relatives of cervical dystonia patients...
2015: Frontiers in Neurology
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