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https://www.readbyqxmd.com/read/27893548/pressureless-orbital-decompression-for-myopic-proptosis
#1
Saul N Rajak, Richard A McGovern, Dinesh Selva
Orbital decompression surgery increases the orbital volume. It has rarely been used for proptosis of the large highly myopic globe. However, external decompression surgery carries significant risks because of the large thin-walled globe. The authors report the first use of endoscopic medial wall orbital decompression surgery in this setting to obviate the risk of globe pressure.Endoscopic medial wall decompression brought about a 4 mm reduction of proptosis, correction of exotropia and elimination of retrobulbar ache providing good symmetry with the fellow eye...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27875632/variable-phenotypic-expression-and-onset-in-myh14-distal-hmn-phenotype-in-a-large-multigenerational-north-american-family
#2
Stanley Iyadurai, W David Arnold, John T Kissel, Corey Ruhno, Vicki L McGovern, Pamela J Snyder, Thomas W Prior, Jennifer Roggenbuck, Arthur H Burghes, Stephen J Kolb
INTRODUCTION: Distal hereditary motor neuropathy (dHMN) causes distal-predominant weakness without prominent sensory loss. Myosin heavy chain disorders most commonly result in distal myopathy and cardiomyopathy with or without hearing loss, but a complex phenotype with dHMN, myopathy, hoarseness, and hearing loss was reported in a Korean family with a c.2822G>T mutation in MYH14. OBJECTIVE: To report phenotypic features in a North American family with the c.2822G>T in MYH14...
November 22, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27873085/quantitative-analysis-of-supporting-cell-subtype-labeling-among-creer-lines-in-the-neonatal-mouse-cochlea
#3
Melissa M McGovern, Joseph Brancheck, Auston C Grant, Kaley A Graves, Brandon C Cox
Four CreER lines that are commonly used in the auditory field to label cochlear supporting cells (SCs) are expressed in multiple SC subtypes, with some lines also showing reporter expression in hair cells (HCs). We hypothesized that altering the tamoxifen dose would modify CreER expression and target subsets of SCs. We also used two different reporter lines, ROSA26 (tdTomato) and CAG-eGFP, to achieve the same goal. Our results confirm previous reports that Sox2 (CreERT2) and Fgfr3-iCreER (T2) are not only expressed in neonatal SCs but also in HCs...
November 21, 2016: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/27769210/efficacy-and-safety-profile-of-nab-paclitaxel-plus-gemcitabine-in-patients-with-metastatic-pancreatic-cancer-treated-to-disease-progression-a-subanalysis-from-a-phase-3-trial-mpact
#4
Arndt Vogel, Josefine Römmler-Zehrer, Jack Shiansong Li, Desmond McGovern, Alfredo Romano, Michael Stahl
BACKGROUND: The phase 3 MPACT trial in patients with metastatic pancreatic cancer demonstrated superior efficacy of nab-paclitaxel (nab-P) + gemcitabine (Gem) vs Gem monotherapy for all endpoints examined including overall survival, the primary endpoint. In the MPACT trial, patients were treated until progressive disease (PD) or unacceptable toxicity. The current exploratory analysis investigated outcomes of patients from the MPACT trial who were treated until PD, in order to understand how to maximize treatment benefit from nab-P + Gem...
October 21, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27647704/epidemiological-clinical-and-genetic-aspects-of-adult-onset-isolated-focal-dystonia-in-ireland
#5
L Williams, E McGovern, O Kimmich, A Molloy, I Beiser, J S Butler, F Molloy, P Logan, D G Healy, T Lynch, R Walsh, L Cassidy, P Moriarty, H Moore, T McSwiney, C Walsh, S O'Riordan, M Hutchinson
BACKGROUND: Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder. AIM: To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland. METHODS: Patients with adult onset idiopathic isolated focal dystonia were recruited from multiple sources...
September 19, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27521810/design-rationale-and-baseline-characteristics-of-the-randomized-double-blind-phase-ii-clinical-trial-of-ibudilast-in-progressive-multiple-sclerosis
#6
Robert J Fox, Christopher S Coffey, Merit E Cudkowicz, Trevis Gleason, Andrew Goodman, Eric C Klawiter, Kazuko Matsuda, Michelle McGovern, Robin Conwit, Robert Naismith, Akshata Ashokkumar, Robert Bermel, Dixie Ecklund, Maxine Koepp, Jeffrey Long, Sneha Natarajan, Srividya Ramachandran, Thomai Skaramagas, Brenda Thornell, Jon Yankey, Mark Agius, Khurram Bashir, Bruce Cohen, Patricia Coyle, Silvia Delgado, Dana Dewitt, Angela Flores, Barbara Giesser, Myla Goldman, Burk Jubelt, Neil Lava, Sharon Lynch, Augusto Miravalle, Harold Moses, Daniel Ontaneda, Jai Perumal, Michael Racke, Pavle Repovic, Claire Riley, Christopher Severson, Shlomo Shinnar, Valerie Suski, Bianca Weinstock-Gutman, Vijayshree Yadav, Aram Zabeti
BACKGROUND: Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS), is characterized by gradual progression of disability. The current anti-inflammatory treatments for MS have little or no efficacy in PMS in the absence of obvious active inflammation. Optimal biomarkers for phase II PMS trials is unknown. Ibudilast is an inhibitor of macrophage migration inhibitor factor and phosphodiesterases-4 and -10 and exhibits possible neuroprotective properties...
September 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27508510/increased-prevalence-of-inflammatory-bowel-disease-in-patients-with-mutations-in-genes-encoding-the-receptor-subunits-for-tgf%C3%AE
#7
Anthony L Guerrerio, Pamela A Frischmeyer-Guerrerio, Chengrui Huang, Yuqiong Wu, Talin Haritunians, Dermot P B McGovern, Gretchen L MacCarrick, Steven R Brant, Harry C Dietz
BACKGROUND: TGFβ is a multifunctional cytokine that is critical in regulating mucosal immunity. Murine studies have revealed that disruption of canonical TGFβ signaling leads to systemic inflammation including colitis. Loeys-Dietz syndrome (LDS) results from heterozygous mutations in the genes encoding the subunits of the TGFβ receptor. METHODS: All patients with confirmed mutations in TGFBR1 or TGFBR2, seen in the Johns Hopkins Connective Tissue Disorders clinic, were asked to participate in the study...
September 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27421662/functional-characterization-of-an-oxytocin-receptor-gene-variant-rs2268498-previously-associated-with-social-cognition-by-expression-analysis-in-vitro-and-in-human-brain-biopsy
#8
Martin Reuter, Christian Montag, Steffen Altmann, Fabian Bendlow, Christian Elger, Peter Kirsch, Albert Becker, Susanne Schoch-McGovern, Matthias Simon, Bernd Weber, Andrea Felten
The oxytocin system plays a prominent role in social behaviour across species, and numerous genetic studies in humans have reported associations between polymorphisms on the oxytocin receptor gene (OXTR) and phenotypes related to social cognition, affiliation, perspective taking and sociability in healthy subjects and in patients with atypical social behaviour, such as in autistic spectrum disorders (ASD). Recently, the first study demonstrating altered agonist-induced OXTR internalization and recycling for the exonic variant rs35062132 emerged...
July 15, 2016: Social Neuroscience
https://www.readbyqxmd.com/read/27376534/prp-aggregation-can-be-seeded-by-pre-formed-recombinant-prp-amyloid-fibrils-without-the-replication-of-infectious-prions
#9
Rona M Barron, Declan King, Martin Jeffrey, Gillian McGovern, Sonya Agarwal, Andrew C Gill, Pedro Piccardo
Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy (TSE) has been described following inoculation and passage of various forms of fibrils in transgenic mice and hamsters...
October 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27284481/dose-modification-and-efficacy-of-nab-paclitaxel-plus-gemcitabine-vs-gemcitabine-for-patients-with-metastatic-pancreatic-cancer-phase-iii-mpact-trial
#10
Werner Scheithauer, Ramesh K Ramanathan, Malcolm Moore, Teresa Macarulla, David Goldstein, Pascal Hammel, Volker Kunzmann, Helen Liu, Desmond McGovern, Alfredo Romano, Daniel D Von Hoff
BACKGROUND: Dose modifications following adverse events (AEs) are an important part of the management of patients with pancreatic cancer treated with chemotherapy. While dose modifications are utilized to ensure patient safety, the subsequent influence of dose adjustments on treatment exposure and efficacy have not been reported in detail. This exploratory analysis examined the influence of dose modifications on treatment exposure and efficacy in the phase III MPACT trial, which demonstrated superior efficacy of nab-paclitaxel (nab-P) plus gemcitabine (Gem) to Gem alone for the treatment of metastatic pancreatic cancer...
June 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27180092/total-mucosal-irradiation-with-intensity-modulated-radiotherapy-in-patients-with-head-and-neck-carcinoma-of-unknown-primary-a-pooled-analysis-of-two-prospective-studies
#11
T M Richards, S A Bhide, A B Miah, L Del Rosario, S Bodla, K Thway, D M Gujral, K P Rooney, U Schick, T McGovern, L Grove, K L Newbold, K J Harrington, C M Nutting
AIMS: To determine the clinical outcomes of an intensity-modulated radiotherapy technique for total mucosal irradiation (TM-IMRT) in patients with head and neck carcinoma of unknown primary (HNCUP). MATERIALS AND METHODS: A single-centre prospective phase II trial design was used in two sequential studies to evaluate TM-IMRT for HNCUP. Patients were investigated for primary tumour site using examination under anaesthetic and biopsies, computed tomography ± magnetic resonance imaging (MRI) or 18-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT)...
September 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27174305/global-burden-of-diseases-injuries-and-risk-factors-for-young-people-s-health-during-1990-2013-a-systematic-analysis-for-the-global-burden-of-disease-study-2013
#12
Ali H Mokdad, Mohammad Hossein Forouzanfar, Farah Daoud, Arwa A Mokdad, Charbel El Bcheraoui, Maziar Moradi-Lakeh, Hmwe Hmwe Kyu, Ryan M Barber, Joseph Wagner, Kelly Cercy, Hannah Kravitz, Megan Coggeshall, Adrienne Chew, Kevin F O'Rourke, Caitlyn Steiner, Marwa Tuffaha, Raghid Charara, Essam Abdullah Al-Ghamdi, Yaser Adi, Rima A Afifi, Hanan Alahmadi, Fadia AlBuhairan, Nicholas Allen, Mohammad AlMazroa, Abdulwahab A Al-Nehmi, Zulfa AlRayess, Monika Arora, Peter Azzopardi, Carmen Barroso, Mohammed Basulaiman, Zulfiqar A Bhutta, Chris Bonell, Cecilia Breinbauer, Louisa Degenhardt, Donna Denno, Jing Fang, Adesegun Fatusi, Andrea B Feigl, Ritsuko Kakuma, Nadim Karam, Elissa Kennedy, Tawfik A M Khoja, Fadi Maalouf, Carla Makhlouf Obermeyer, Amitabh Mattoo, Terry McGovern, Ziad A Memish, George A Mensah, Vikram Patel, Suzanne Petroni, Nicola Reavley, Diego Rios Zertuche, Mohammad Saeedi, John Santelli, Susan M Sawyer, Fred Ssewamala, Kikelomo Taiwo, Muhammad Tantawy, Russell M Viner, Jane Waldfogel, Maria Paola Zuñiga, Mohsen Naghavi, Haidong Wang, Theo Vos, Alan D Lopez, Abdullah A Al Rabeeah, George C Patton, Christopher J L Murray
BACKGROUND: Young people's health has emerged as a neglected yet pressing issue in global development. Changing patterns of young people's health have the potential to undermine future population health as well as global economic development unless timely and effective strategies are put into place. We report the past, present, and anticipated burden of disease in young people aged 10-24 years from 1990 to 2013 using data on mortality, disability, injuries, and health risk factors. METHODS: The Global Burden of Disease Study 2013 (GBD 2013) includes annual assessments for 188 countries from 1990 to 2013, covering 306 diseases and injuries, 1233 sequelae, and 79 risk factors...
June 11, 2016: Lancet
https://www.readbyqxmd.com/read/27104820/tnfrsf1b-is-associated-with-anca-in-ibd
#13
Dalin Li, Mark S Silverberg, Talin Haritunians, Marla C Dubinsky, Carol Landers, Joanne M Stempak, Raquel Milgrom, Xiuqing Guo, Yii-Der Ida Chen, Jerome I Rotter, Kent D Taylor, Dermot P B McGovern, Stephan R Targan
The genetic basis of antineutrophil cytoplasmic antibody, an important biomarker of inflammatory bowel disease (IBD), has never been thoroughly examined on a genome-wide scale. In this study, we performed a 2-stage genome-wide association study (GWAS) on antineutrophil cytoplasmic antibody in IBD cases. In the 2959 IBD cases in the discovery stage, we observed an association between a variant in the gene TNFRSF1B with antineutrophil cytoplasmic antibody level (rs5745994, minor allele frequency = 0.028, beta = 18...
June 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27102978/clinical-and-neuropsychiatric-correlates-of-lumbar-spinal-surgery-in-older-adults-results-of-a-pilot-study
#14
Jordan F Karp, Jonathan McGovern, Megan M Marron, Peter Gerszten, Debra K Weiner, David Okonkwo, Adam S Kanter
AIM: To improve selection of older lumbar surgical candidates, we surveyed correlates of functioning and satisfaction with surgery. MATERIALS & METHODS: Prospective sample at lumbar spine surgery clinic. Patients (n = 48) were evaluated before surgery and after 3 months. Dependent variables were functioning and surgical satisfaction. RESULTS: Baseline variables associated with disability at 3 months included cognitive status and widespread pain...
November 2016: Pain Management
https://www.readbyqxmd.com/read/26990269/physical-health-lifestyle-beliefs-and-behaviors-and-mental-health-of-entering-graduate-health-professional-students-evidence-to-support-screening-and-early-intervention
#15
Bernadette Mazurek Melnyk, Caitlin Slevin, Lisa Militello, Jacqueline Hoying, Alice Teall, Colleen McGovern
BACKGROUND AND PURPOSE: Little is known about the physical health, lifestyle beliefs and behaviors, and mental health among first-year health professional graduate students. Therefore, the purpose of this study was to describe these attributes as well as to explore the relationships among them. METHODS: A descriptive correlational study was conducted on the baseline data from a wellness onboarding intervention study with 93 health sciences students from seven different colleges within a large public land grant university in the Midwest United States...
April 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/26937622/perianal-crohn-s-disease-is-associated-with-distal-colonic-disease-stricturing-disease-behavior-ibd-associated-serologies-and-genetic-variation-in-the-jak-stat-pathway
#16
Manreet Kaur, Deepa Panikkath, Xiaofei Yan, Zhenqiu Liu, Dror Berel, Dalin Li, Eric A Vasiliauskas, Andrew Ippoliti, Marla Dubinsky, David Q Shih, Gil Y Melmed, Talin Haritunians, Phillip Fleshner, Stephan R Targan, Dermot P B McGovern
BACKGROUND: Perianal Crohn's Disease (pCD) is a particularly severe phenotype associated with poor quality of life with a reported prevalence of 12%-40%. Previous studies investigating the etiology of pCD have been limited in the numbers of subjects and the intensity of genotyping. The aim of this study was to identify clinical, serological, and genetic factors associated with pCD. METHODS: We performed a case-control study comparing patients with (pCD+) and without perianal (pCD) involvement in CD; defined as the presence of perianal abscesses or fistulae...
April 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26900669/using-a-learning-collaborative-strategy-with-office-based-practices-to-increase-access-and-improve-quality-of-care-for-patients-with-opioid-use-disorders
#17
Benjamin R Nordstrom, Elizabeth C Saunders, Bethany McLeman, Andrea Meier, Haiyi Xie, Chantal Lambert-Harris, Beth Tanzman, John Brooklyn, Gregory King, Nels Kloster, Clifton Frederick Lord, William Roberts, Mark P McGovern
OBJECTIVES: Rapidly escalating rates of heroin and prescription opioid use have been widely observed in rural areas across the United States. Although US Food and Drug Administration-approved medications for opioid use disorders exist, they are not routinely accessible to patients. One medication, buprenorphine, can be prescribed by waivered physicians in office-based practice settings, but practice patterns vary widely. This study explored the use of a learning collaborative method to improve the provision of buprenorphine in the state of Vermont...
March 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/26802160/ca19-9-decrease-at-8-weeks-as-a-predictor-of-overall-survival-in-a-randomized-phase-iii-trial-mpact-of-weekly-nab-paclitaxel-plus-gemcitabine-versus-gemcitabine-alone-in-patients-with-metastatic-pancreatic-cancer
#18
E G Chiorean, D D Von Hoff, M Reni, F P Arena, J R Infante, V G Bathini, T E Wood, P N Mainwaring, R T Muldoon, P R Clingan, V Kunzmann, R K Ramanathan, J Tabernero, D Goldstein, D McGovern, B Lu, A Ko
BACKGROUND: A phase I/II study and subsequent phase III study (MPACT) reported significant correlations between CA19-9 decreases and prolonged overall survival (OS) with nab-paclitaxel plus gemcitabine (nab-P + Gem) treatment for metastatic pancreatic cancer (MPC). CA19-9 changes at week 8 and potential associations with efficacy were investigated as part of an exploratory analysis in the MPACT trial. PATIENTS AND METHODS: Untreated patients with MPC (N = 861) received nab-P + Gem or Gem alone...
April 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26789072/reporting-in%C3%A2-vitro-fertilization-cycles-to-the-society-for-assisted-reproductive-technology-database-where-have-all-the-cycles-gone
#19
David Kulak, Sangita K Jindal, Cheongeun Oh, Sara S Morelli, Scott Kratka, Peter G McGovern
OBJECTIVE: To assess the relationship between live birth rates (LBRs) and the incidence of under-reported cycles by IVF clinics. DESIGN: Cohort study. SETTING: Not applicable. PATIENT(S): All patients undergoing IVF cycles in the aforementioned clinics. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE(S): The reporting percentage (RP), defined as number of cycles with reported pregnancy rates divided by total cycles performed...
April 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/26773331/glucose-test-provenance-recording-in-uk-primary-care-was-that-fasted-or-random
#20
A P McGovern, H Fieldhouse, Z Tippu, S Jones, N Munro, S de Lusignan
AIMS: To describe the proportion of glucose tests with unrecorded provenance in routine primary care data and identify the impact on clinical practice. METHODS: A cross-sectional analysis was conducted of blood glucose measurements from the Royal College of General Practitioner Research and Surveillance Centre database, which includes primary care records from >100 practices across England and Wales. All blood glucose results recorded during 2013 were identified...
January 16, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
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