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https://www.readbyqxmd.com/read/29584801/immunochip-meta-analysis-of-inflammatory-bowel-disease-identifies-three-novel-loci-and-four-novel-associations-in-previously-reported-loci
#1
Myunghee Hong, Byong Duk Ye, Suk-Kyun Yang, Seulgi Jung, Ho-Su Lee, Byoung Mok Kim, Soo Bin Lee, Jeonghoon Hong, Jiwon Baek, Sang Hyoung Park, Buhm Han, Yi Li, Wenting Liu, Talin Haritunians, Kent D Taylor, Jerome I Rotter, So-Young Bang, Tae-Hwan Kim, Dermot P B McGovern, Jianjun Liu, Kyuyoung Song
Background and Aims: Recent meta-analysis of genome-wide association studies have identified over 241 inflammatory bowel disease susceptibility loci. However, the known variants only account for a fraction of inflammatory bowel disease heritability. To identify additional susceptibility loci, we performed a trans-ethnic meta-analysis as well as an Asian-specific meta-analysis using all published Immunochip association results of inflammatory bowel disease. Methods: An inverse-variance fixed-effects meta-analysis was carried out across Korean and East Asian Immunochip datasets of 4,156 cases and 4,904 controls (Asian ancestry)...
March 23, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29582721/extensive-hepatitis-a-outbreak-in-an-urban-childcare-facility-in-ireland-associated-with-considerable-adult-morbidity
#2
L O'Connor, E McGovern, M O'Meara, J Dean, M Ward, M O'Connor
Hepatitis A infection results in a spectrum of illness from asymptomatic disease to severe fulminant hepatitis. Since 2000, <50 cases have been reported annually in Ireland. We report on an outbreak of hepatitis A associated with a childcare facility(CCF) in 2015 in Ireland. Between January and July 2015, 12 outbreak-associated symptomatic hepatitis A cases were identified, including one delayed, retrospective diagnosis. Seven (58%) cases were adults, eight (67%) were male, six of the adults required hospitalisation...
March 27, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29565250/first-isolation-of-brucella-pinnipedialis-and-detection-of-brucella-antibodies-from-bearded-seals-erignathus-barbatus
#3
Geoffrey Foster, Ingebjørg H Nymo, Kit M Kovacs, Kimberlee B Beckmen, Andrew C Brownlow, Johanna L Baily, Mark P Dagleish, Jakub Muchowski, Lorraine L Perrett, Morten Tryland, Christian Lydersen, Jacques Godfroid, Barry McGovern, Adrian M Whatmore
Brucella species infecting marine mammals was first reported in 1994 and in the years since has been documented in various species of pinnipeds and cetaceans. While these reports have included species that inhabit Arctic waters, the few available studies on bearded seals Erignathus barbatus have failed to detect Brucella infection to date. We report the first isolation of Brucella pinnipedialis from a bearded seal. The isolate was recovered from the mesenteric lymph node of a bearded seal that stranded in Scotland and typed as ST24, a sequence type associated typically with pinnipeds...
March 22, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29525296/further-evidence-for-a-distinctive-atypical-degenerative-parkinsonism-in-the-caribbean-a-new-cluster-in-the-french-west-indian-island-of-martinique
#4
Annie Lannuzel, Régine Edragas, Angéla Lackmy, Benoit Tressières, Véronique Pelonde, Mireille Edimo Nana Kaptué, Sylvie Mécharles, Alexis Demas, Billy François, Eavan McGovern, Marie Vidailhet, Bertrand Gaymard, Emmanuel Roze
BACKGROUND: A high prevalence of an atypical levodopa-resistant parkinsonism has been reported in the Caribbean island of Guadeloupe. These seminal observations have not been replicated or extended to neighbouring populations who share genetic and environmental characteristics. METHODS: To further characterise this atypical parkinsonism we prospectively investigated 305 consecutive patients with neurodegenerative parkinsonism in a community-based population from Guadeloupe and Martinique, a neighbouring French Caribbean island where the population has similar environmental and genetic backgrounds...
February 6, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29432793/the-impact-of-natural-aging-on-computational-and-neural-indices-of-perceptual-decision-making-a-review
#5
REVIEW
Jessica Dully, David P McGovern, Redmond G O'Connell
It is well established that natural aging negatively impacts on a wide variety of cognitive functions and research has sought to identify core neural mechanisms that may account for these disparate changes. A central feature of any cognitive task is the requirement to translate sensory information into an appropriate action - a process commonly known as perceptual decision making. While computational, psychophysical, and neurophysiological research has made substantial progress in establishing the key computations and neural mechanisms underpinning decision making, it is only relatively recently that this knowledge has begun to be applied to research on aging...
February 9, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29367014/internal-validation-of-strmix%C3%A2-a-multi-laboratory-response-to-pcast
#6
Jo-Anne Bright, Rebecca Richards, Maarten Kruijver, Hannah Kelly, Catherine McGovern, Alan Magee, Andrew McWhorter, Anne Ciecko, Brian Peck, Chase Baumgartner, Christina Buettner, Scott McWilliams, Claire McKenna, Colin Gallacher, Ben Mallinder, Darren Wright, Deven Johnson, Dorothy Catella, Eugene Lien, Craig O'Connor, George Duncan, Jason Bundy, Jillian Echard, John Lowe, Joshua Stewart, Kathleen Corrado, Sheila Gentile, Marla Kaplan, Michelle Hassler, Naomi McDonald, Paul Hulme, Rachel H Oefelein, Shawn Montpetit, Melissa Strong, Sarah Noël, Simon Malsom, Steven Myers, Susan Welti, Tamyra Moretti, Teresa McMahon, Thomas Grill, Tim Kalafut, MaryMargaret Greer-Ritzheimer, Vickie Beamer, Duncan A Taylor, John S Buckleton
We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing...
January 8, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29361085/the-influence-of-hormonal-fluctuation-on-inflammatory-bowel-disease-symptom-severity-a-cross-sectional-cohort-study
#7
Vineet S Rolston, Laleh Boroujerdi, Millie D Long, Dermot P B McGovern, Wenli Chen, Christopher F Martin, Robert S Sandler, John D Carmichael, Marla Dubinsky, Gil Y Melmed
Background: Many women with inflammatory bowel disease (IBD) report changes in symptoms in association with hormonal changes during menses, pregnancy, and hormonal contraceptive use, suggesting a hormonal influence on disease activity. We aimed to identify and characterize IBD symptom fluctuations in women during times of hormonal variation. Methods: From June 2012 through September 2012, women enrolled in Crohn's and Colitis Foundation of America Partners , an online Internet cohort of patients with IBD, were invited to participate in this study...
January 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29351039/resorbable-plates-in-secondary-cleft-nasal-reconstruction
#8
Pey-Yi Lin, Anthony P Gibson, John F Teichgraeber, Matthew R Greives
OBJECTIVE: The authors report on the use and complications of alloplastic resorbable plates and compare their use to autologous cartilage grafts in secondary cleft nasal reconstruction. DESIGN: Institutional review board (IRB)-approved retrospective chart review. SETTING: Texas Cleft-Craniofacial Center at the McGovern Medical School at the University of Texas Health Sciences Center at Houston. PATIENTS: Patients with unilateral or bilateral cleft lip nasal deformity who have undergone secondary correction of their nasal deformity with at least 1-year follow-up...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29347821/fluorescence-and-excited-state-conformational-dynamics-of-the-orange-carotenoid-protein
#9
Jason K Gurchiek, Han Bao, Maria Agustina Domínguez-Martín, Sarah E McGovern, Claire E Marquardt, Jerome D Roscioli, Soumen Ghosh, Cheryl A Kerfeld, Warren F Beck
The orange carotenoid protein (OCP) mediates nonphotochemical quenching (NPQ) mechanisms in cyanobacteria. A bound ketocarotenoid serves as a sensor of midvisible light intensity and as a quencher of phycocyanobilin excitons in the phycobilisome. The photochemical mechanism that triggers conversion of the protein from a resting, orange state (OCPO ) to an active, red state (OCPR ) after optical preparation of the S2 state of the carotenoid remains an open question. We report here that the fluorescence spectrum and quantum yield of the bound carotenoids in OCPO report important details of the motions that follow optical preparation of the S2 state...
February 15, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29330502/targeting-insulin-like-growth-factor-i-and-extracellular-matrix-interactions-in-melanoma-progression
#10
Berline Murekatete, Ali Shokoohmand, Jacqui McGovern, Lipsa Mohanty, Christoph Meinert, Brett G Hollier, Alfred Zippelius, Zee Upton, Abhishek S Kashyap
Insulin-like growth factor (IGF)-I binds to the ECM protein vitronectin (VN) through IGF binding proteins (IGFBPs) to enhance proliferation and migration of skin keratinocytes and fibroblasts. Although evidence exists for the role of individual components of the complex (IGF-I, IGFBP-3 and VN), the cellular functions stimulated by these proteins together as a complex remains un-investigated in melanoma cells. We report here that the IGF-I:IGFBP-3:VN trimeric complex stimulates a dose-dependent increase in the proliferation and migration of WM35 and Sk-MEL28 melanoma cells...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29189286/epidural-anesthesia-to-facilitate-organ-blood-flow-during-the-first-penile-transplantation-in-the-united-states-a-case-report
#11
Katarina J Ruscic, Grettel J Zamora-Berridi, Francis J McGovern, Curtis Cetrulo, Jonathan M Winograd, Kyle R Eberlin, Branko Bojovic, Dicken S Ko, T Anthony Anderson
Regional anesthesia has been used to help create local sympathectomy and improve blood flow in plastic surgery procedures involving tissue grafts and flaps. However, anesthetic techniques that reduce systemic vascular resistance must be used with caution in patients with aortic stenosis (AS). Combined neuraxial and general anesthesia with careful titration of the local anesthetic dose can be a safe approach for patients with AS undergoing microvascular procedures. We present the anesthetic management of the first North American penile transplant, on an obese patient with moderate AS...
November 16, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29135080/comparison-of-medication-adherence-and-persistence-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#12
Andrew McGovern, Zayd Tippu, William Hinton, Neil Munro, Martin Whyte, Simon de Lusignan
Limited medication adherence and persistence with treatment are barriers to successful management of type 2 diabetes (T2D). We searched MEDLINE, EMBASE, the Cochrane Library, the Register of Controlled Trials, PsychINFO and CINAHL for observational and interventional studies that compared the adherence or persistence associated with 2 or more glucose-lowering medications in people with T2D. Where 5 or more studies provided the same comparison, a random-effects meta-analysis was performed, reporting mean difference (MD) or odds ratio (OR) for adherence or persistence, depending on the pooled study outcomes...
April 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29117204/prevalence-of-binary-toxin-positive-clostridium-difficile-in-diarrhoeal-humans-in-the-absence-of-epidemic-ribotype-027
#13
Alan M McGovern, Grace O Androga, Daniel R Knight, Mark W Watson, Briony Elliott, Niki F Foster, Barbara J Chang, Thomas V Riley
Virulence of Clostridium difficile is primarily attributed to the large clostridial toxins A and B while the role of binary toxin (CDT) remains unclear. The prevalence of human strains of C. difficile possessing only CDT genes (A-B-CDT+) is generally low (< 5%), however, this genotype is commonly found in neonatal livestock both in Australia and elsewhere. Zoonotic transmission of C. difficile has been suggested previously. Most human diagnostic tests will not detect A-B-CDT+ strains of C. difficile because they focus on detection of toxin A and/or B...
2017: PloS One
https://www.readbyqxmd.com/read/29112734/memantine-prevents-acute-radiation-induced-toxicities-at-hippocampal-excitatory-synapses
#14
Joseph G Duman, Jeffrey Dinh, Wei Zhou, Henry Cham, Vasilis C Mavratsas, Matea Paveškovic, Shalaka Mulherkar, Susan L McGovern, Kimberley F Tolias, David R Grosshans
Background: Memantine has shown clinical utility in preventing radiation-induced cognitive impairment, but the mechanisms underlying its protective effects remain unknown. We hypothesized that abnormal glutamate signaling causes radiation-induced abnormalities in neuronal structure and that memantine prevents synaptic toxicity. Methods: Hippocampal cultures expressing eGFP were irradiated or sham-treated and their dendritic spine morphology assessed at acute (minutes) and later (days) times using high-resolution confocal microscopy...
November 2, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29095427/centrally-determined-standardization-of-flow-cytometry-methods-reduces-interlaboratory-variation-in-a-prospective-multicenter-study
#15
Liset Westera, Tanja van Viegen, Jenny Jeyarajah, Azar Azad, Janine Bilsborough, Gijs R van den Brink, Jonathan Cremer, Silvio Danese, Geert D'Haens, Lars Eckmann, William Faubion, Melissa Filice, Hannelie Korf, Dermot McGovern, Julian Panes, Azucena Salas, William J Sandborn, Mark S Silverberg, Michelle I Smith, Severine Vermeire, Stefania Vetrano, Lisa M Shackelton, Larry Stitt, Vipul Jairath, Barrett G Levesque, David M Spencer, Brian G Feagan, Niels Vande Casteele
OBJECTIVES: Flow cytometry (FC) aids in characterization of cellular and molecular factors involved in pathologic immune responses. Although FC has potential to facilitate early drug development in inflammatory bowel disease, interlaboratory variability limits its use in multicenter trials. Standardization of methods may address this limitation. We compared variability in FC-aided quantitation of T-cell responses across international laboratories using three analytical strategies. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from three healthy donors, stimulated with phorbol 12-myristate 13-acetate and ionomycin at a central laboratory, fixed, frozen, and shipped to seven international laboratories...
November 2, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28890854/quantitative-comparison-of-the-spreading-and-invasion-of-radial-growth-phase-and-metastatic-melanoma-cells-in-a-three-dimensional-human-skin-equivalent-model
#16
Parvathi Haridas, Jacqui A McGovern, Sean D L McElwain, Matthew J Simpson
BACKGROUND: Standard two-dimensional (2D) cell migration assays do not provide information about vertical invasion processes, which are critical for melanoma progression. We provide information about three-dimensional (3D) melanoma cell migration, proliferation and invasion in a 3D melanoma skin equivalent (MSE) model. In particular, we pay careful attention to compare the structure of the tissues in the MSE with similarly-prepared 3D human skin equivalent (HSE) models. The HSE model is identically prepared to the MSE model except that melanoma cells are omitted...
2017: PeerJ
https://www.readbyqxmd.com/read/28817446/bevacizumab-as-an-effective-treatment-for-radiation-necrosis-after-radiotherapy-for-melanoma-brain-metastases
#17
Isabella C Glitza, Nandita Guha-Thakurta, Neil M D'Souza, Rodabe N Amaria, Susan L McGovern, Ganesh Rao, Jing Li
Radiation necrosis (RN) is a potential late complication of radiotherapy for intracranial malignancy, which is often associated with significant neurological morbidity. Prolonged treatment with high-dose corticosteroids or surgical resection has been the standard care for RN, but protracted steroid use can lead to significant side effects and surgical resection is not always feasible. The antivascular endothelial growth factor monoclonal antibody bevacizumab induces clinical and radiographic improvements in RN, with overall good tolerance...
December 2017: Melanoma Research
https://www.readbyqxmd.com/read/28759310/ultrastructure-and-pathology-of-prion-protein-amyloid-accumulation-and-cellular-damage-in-extraneural-tissues-of-scrapie-infected-transgenic-mice-expressing-anchorless-prion-protein
#18
Brent Race, Martin Jeffrey, Gillian McGovern, David Dorward, Bruce Chesebro
In most human and animal prion diseases the abnormal disease-associated prion protein (PrPSc) is deposited as non-amyloid aggregates in CNS, spleen and lymphoid organs. In contrast, in humans and transgenic mice with PrP mutations which cause expression of PrP lacking a glycosylphosphatidylinositol (GPI)-anchor, most PrPSc is in the amyloid form. In transgenic mice expressing only anchorless PrP (tg anchorless), PrPSc is deposited not only in CNS and lymphoid tissues, but also in extraneural tissues including heart, brown fat, white fat, and colon...
July 4, 2017: Prion
https://www.readbyqxmd.com/read/28752233/upper-limb-lymphedema-in-breast-cancer-patients-in-the-era-of-z0011-sentinel-lymph-node-biopsy-and-breast-conservation
#19
N R Bhatt, M R Boland, R McGovern, A Lal, S Tormey, A J Lowery, B A Merrigan
INTRODUCTION: Surgical techniques in breast cancer (BCa) have seen a dramatic change recently with breast-conserving surgery (BCS) and sentinel lymph node biopsy (SLNB). The ACOSOG-Z0011 trial reported equivalence in outcomes for certain patients with SLN metastases treated with axillary lymph node dissection (ALND) or SLNB alone. Our aim was to investigate changes in lymphedema referral patterns in BCa patients over the last 3 years in a specialist unit and to elucidate effects of SLNB, BCS, and Z0011 trial publication on such patterns...
July 27, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28712950/predictors-of-laparoscopic-simulation-performance-among-practicing-obstetrician-gynecologists
#20
Shyama Mathews, Michael Brodman, Debra D'Angelo, Scott Chudnoff, Peter McGovern, Tamara Kolev, Giti Bensinger, Santosh Mudiraj, Andreea Nemes, David Feldman, Patricia Kischak, Charles Ascher-Walsh
BACKGROUND: While simulation training has been established as an effective method for improving laparoscopic surgical performance in surgical residents, few studies have focused on its use for attending surgeons, particularly in obstetrics and gynecology. Surgical simulation may have a role in improving and maintaining proficiency in the operating room for practicing obstetrician gynecologists. OBJECTIVE: We sought to determine if parameters of performance for validated laparoscopic virtual simulation tasks correlate with surgical volume and characteristics of practicing obstetricians and gynecologists...
November 2017: American Journal of Obstetrics and Gynecology
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