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Mcgovern report

Emily C Holden, Banafsheh N Kashani, Sara S Morelli, Donald Alderson, Sangita K Jindal, Pamela A Ohman-Strickland, Peter G McGovern
OBJECTIVE: To investigate whether there is a difference in obstetrical and perinatal outcomes in blastocyst frozen-thawed embryo transfers (FETs) compared with cleavage-stage FET. DESIGN: A retrospective cohort study. SETTING: Not applicable. PATIENT(S): Women undergoing autologous FETs at either the blastocyst stage (n = 118,572) or the cleavage stage (n = 117,619) reported to the Society for Assisted Reproductive Technology in the years 2004-2013...
June 13, 2018: Fertility and Sterility
Christina E McGovern, Corjena Cheung
INTRODUCTION: Primary dysmenorrhea is a prevalent condition causing quality of life (QOL) reduction for many women, resulting from pain as well as parallel social and psychological distress. Yoga reduces pain and sympathetic reactivity, thus promoting QOL. This article reports a systematic review of the evidence for the effectiveness of yoga as a QOL improvement method for women with primary dysmenorrhea. METHODS: The PRISMA guidelines were used in preparation of this review...
June 14, 2018: Journal of Midwifery & Women's Health
Michelle Addison, Ruth Mcgovern, Colin Angus, Frauke Becker, Alan Brennan, Heather Brown, Simon Coulton, Lisa Crowe, Eilish Gilvarry, Matthew Hickman, Denise Howel, Elaine Mccoll, Colin Muirhead, Dorothy Newbury-Birch, Muhammad Waqas, Eileen Kaner
Aims: There is a clear association between alcohol use and offending behaviour and significant police time is spent on alcohol-related incidents. This study aimed to test the feasibility of a trial of screening and brief intervention in police custody suites to reduce heavy drinking and re-offending behaviour. Short summary: We achieved target recruitment and high brief intervention delivery if this occurred immediately after screening. Low rates of return for counselling and retention at follow-up were challenges for a definitive trial...
June 8, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
P Findeisen, I Zahn, G M Fiedler, A B Leichtle, S Wang, G Soria, P Johnson, J Henzell, J K Hegel, C Bendavid, N Collet, M McGovern, K Klopprogge
OBJECTIVES: The new immunochemistry cobas e 801 module (Roche Diagnostics) was developed to meet increasing demands on routine laboratories to further improve testing efficiency, while maintaining high quality and reliable data. DESIGN AND METHODS: During a non-interventional multicenter evaluation study, the overall performance, functionality and reliability of the new module was investigated under routine-like conditions. It was tested as a dedicated immunochemistry system at four sites and as a consolidator combined with clinical chemistry at three sites...
June 4, 2018: Clinical Biochemistry
Andrew Lee, Giovanni Greaves, Ruby Lee, Maria Zdravkova, Samrah Ahmad, Kerri McGovern, Christina Ghiuzeli, Maggie Hymowitz
PURPOSE: We describe a case of bilateral angle closure glaucoma following the infusion of daratumumab, a monoclonal antibody used to treat relapsing multiple myeloma. METHODS: Interventional case report. RESULTS: A 59 year old woman presented with bilateral angle closure glaucoma one day following her first infusion of daratumumab. B-scan echography demonstrated ciliochoroidal effusions in both eyes. Cycloplegia was implemented given the suspicion for drug-induced angle closure, which resulted in prompt deepening of the anterior chambers and normalization of intraocular pressures (IOP)...
May 31, 2018: Journal of Glaucoma
Dalin Li, Talin Haritunians, Carol Landers, Alka A Potdar, Shaohong Yang, Hailiang Huang, L Philip Schumm, Mark Daly, Stephan R Targan, Dermot P B McGovern
Background: Age of onset is linked to variations in clinical phenotypes and natural history in Crohn's disease (CD). We aim to define etiologically more homogenous subgroups in CD based on ages of onset. Methods: We examined the distribution of CD polygenetic risk score (PRS) across ages of diagnosis in a Caucasian cohort of 2344 independent CD patients. We identified subgroups with a distinct distribution of PRS and compared those groups in genetics, demographic characteristics, clinical subphenotypes, and serological markers...
May 30, 2018: Inflammatory Bowel Diseases
Katrina D'Amore, David Traficante, Terrance McGovern, Marco Propersi, Stacey Barnes
Alveolar hemorrhage is a rare yet devastating clinical entity if not identified and treated aggressively. Exceedingly rare are the cases of anticoagulant-induced alveolar hemorrhage with very few cases described in the current literature. The nonspecific presentation of an alveolar hemorrhage makes its diagnosis and appropriate treatment difficult in the emergency department. We report a case of a patient on warfarin for atrial fibrillation who was initially misdiagnosed as having community-acquired pneumonia, but subsequently was identified to have a fatal alveolar hemorrhage...
November 2017: Clinical practice and cases in emergency medicine
Terrance McGovern, Justin McNamee, Steven Marcus, Josh Kashani
Cyproheptadine is an H-1 antihistamine with anticholinergic and antiserotonergic effects. Cyproheptadine's most common use has been in the management cold-induced urticaria. It is often used in primary care for its side effect of appetite stimulation. Recently there has been increasing interest in its use in the treatment of drug-induced serotonin syndrome. Cyproheptadine overdose is uncommonly reported in the medical literature. We report the rare case of a pediatric cyproheptadine overdose with a confirmatory cyproheptadine level...
August 2017: Clinical practice and cases in emergency medicine
Vineet S Rolston, Anish V Patel, Thomas J Learch, Dalin Li, Dmitry Karayev, Chadwick Williams, Madhavi L Siddanthi, Stephan R Targan, Michael H Weisman, Dermot P B McGovern
OBJECTIVES: Avascular necrosis (AVN) is associated with significant morbidity potentially causing severe pain and debility; patients with inflammatory bowel disease (IBD) have a higher prevalence of AVN compared with non-IBD populations. The purpose of our study was to determine the prevalence of AVN in our IBD population and to evaluate these subjects for the presence of clinical characteristics associated with AVN on computed tomography (CT) imaging. METHODS: In 1313 IBD patients with abdomen/pelvis CT scans, we identified 27 patients (2...
May 24, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Geoffrey Hutinet, Arthur Besle, Olivier Son, Stephen McGovern, Raphaël Guerois, Marie-Agnès Petit, Françoise Ochsenbein, François Lecointe
Bacteriophages are remarkable for the wide diversity of proteins they encode to perform DNA replication and homologous recombination. Looking back at these ancestral forms of life may help understanding how similar proteins work in more sophisticated organisms. For instance, the Sak4 family is composed of proteins similar to the archaeal RadB protein, a Rad51 paralog. We have previously shown that Sak4 allowed single-strand annealing in vivo , but only weakly compared to the phage λ Redβ protein, highlighting putatively that Sak4 requires partners to be efficient...
2018: Frontiers in Microbiology
Ruth McGovern, Eilish Gilvarry, Michelle Addison, Hayley Alderson, Emma Geijer-Simpson, Raghu Lingam, Debbie Smart, Eileen Kaner
BACKGROUND: Between 5% and 30% of children in high-income countries live with a substance misusing parent, the majority of which is below dependent levels. However, little is understood about the impact of nondependent parental substance misuse upon children. METHODS: We searched the international literature using rigorous systematic methods to identify studies examining parental substance misuse and adverse outcomes in children. The inclusion criteria were cross-sectional, longitudinal, case-control, and cohort studies; of children aged 0-18 years whose parents are high-risk substance misusers; reporting on their health, psychological, substance use, educational, and social outcomes...
January 1, 2018: Trauma, Violence & Abuse
Melissa Mercincavage, Kirsten Lochbuehler, Andrea C Villanti, E Paul Wileyto, Janet Audrain-McGovern, Andrew A Strasser
Introduction: The U.S. Food and Drug Administration (FDA) has stated its interest in reducing the addictiveness of combustible cigarettes by lowering their nicotine content. Delineating risk perceptions of reduced nicotine content (RNC) cigarettes prior to federal regulation may inform the content of future educational campaigns accompanying this policy. Methods: 500 non-treatment-seeking, daily smokers naïve to RNC cigarettes (63.0% male, 51.6% non-White, mean [SD] cigarettes per day = 15...
April 28, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Katarina J Ruscic, Grettel J Zamora-Berridi, Francis J McGovern, Curtis Cetrulo, Jonathan M Winograd, Kyle R Eberlin, Branko Bojovic, Dicken S Ko, T Anthony Anderson
Regional anesthesia has been used to help create local sympathectomy and improve blood flow in plastic surgery procedures involving tissue grafts and flaps. However, anesthetic techniques that reduce systemic vascular resistance must be used with caution in patients with aortic stenosis (AS). Combined neuraxial and general anesthesia with careful titration of the local anesthetic dose can be a safe approach for patients with AS undergoing microvascular procedures. We present the anesthetic management of the first North American penile transplant, on an obese patient with moderate AS...
May 1, 2018: A&A practice
Yu-Ling Chang, Maura Rossetti, Hera Vlamakis, David Casero, Gemalene Sunga, Nicholas Harre, Shelley Miller, Romney Humphries, Thaddeus Stappenbeck, Kenneth W Simpson, R Balfour Sartor, Gary Wu, James Lewis, Frederic Bushman, Dermot P B McGovern, Nita Salzman, James Borneman, Ramnik Xavier, Curtis Huttenhower, Jonathan Braun
Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions induced by disease-associated T helper 17 (Th17) polarizing conditions. We observed 15 metabolites with CD4+ T-cell bioactivity, 3 previously reported, and 12 unprecedented. A deeper investigation of the microbe-derived metabolite, ascorbate, revealed its selective inhibition on activated human CD4+ effector T cells, including IL-17A-, IL-4-, and IFNγ-producing cells...
April 25, 2018: Mucosal Immunology
Myunghee Hong, Byong Duk Ye, Suk-Kyun Yang, Seulgi Jung, Ho-Su Lee, Byoung Mok Kim, Soo Bin Lee, Jeonghoon Hong, Jiwon Baek, Sang Hyoung Park, Buhm Han, Yi Li, Wenting Liu, Talin Haritunians, Kent D Taylor, Jerome I Rotter, So-Young Bang, Tae-Hwan Kim, Dermot P B McGovern, Jianjun Liu, Kyuyoung Song
Background and Aims: Recent meta-analysis of genome-wide association studies have identified over 241 inflammatory bowel disease susceptibility loci. However, the known variants only account for a fraction of inflammatory bowel disease heritability. To identify additional susceptibility loci, we performed a trans-ethnic meta-analysis as well as an Asian-specific meta-analysis, using all published Immunochip association results of inflammatory bowel disease. Methods: An inverse-variance fixed-effects meta-analysis was carried out across Korean and East Asian Immunochip datasets of 4156 cases and 4904 controls [Asian ancestry]...
May 25, 2018: Journal of Crohn's & Colitis
L O'Connor, E McGovern, M O'Meara, J Dean, M Ward, M O'Connor
Hepatitis A infection results in a spectrum of illness from asymptomatic disease to severe fulminant hepatitis. Since 2000, <50 cases have been reported annually in Ireland. We report on an outbreak of hepatitis A associated with a childcare facility(CCF) in 2015 in Ireland. Between January and July 2015, 12 outbreak-associated symptomatic hepatitis A cases were identified, including one delayed, retrospective diagnosis. Seven (58%) cases were adults, eight (67%) were male, six of the adults required hospitalisation...
April 2018: Epidemiology and Infection
Geoffrey Foster, Ingebjørg H Nymo, Kit M Kovacs, Kimberlee B Beckmen, Andrew C Brownlow, Johanna L Baily, Mark P Dagleish, Jakub Muchowski, Lorraine L Perrett, Morten Tryland, Christian Lydersen, Jacques Godfroid, Barry McGovern, Adrian M Whatmore
Brucella species infecting marine mammals was first reported in 1994 and in the years since has been documented in various species of pinnipeds and cetaceans. While these reports have included species that inhabit Arctic waters, the few available studies on bearded seals Erignathus barbatus have failed to detect Brucella infection to date. We report the first isolation of Brucella pinnipedialis from a bearded seal. The isolate was recovered from the mesenteric lymph node of a bearded seal that stranded in Scotland and typed as ST24, a sequence type associated typically with pinnipeds...
March 22, 2018: Diseases of Aquatic Organisms
Annie Lannuzel, Régine Edragas, Angéla Lackmy, Benoit Tressières, Véronique Pelonde, Mireille Edimo Nana Kaptué, Sylvie Mécharles, Alexis Demas, Billy François, Eavan McGovern, Marie Vidailhet, Bertrand Gaymard, Emmanuel Roze
BACKGROUND: A high prevalence of an atypical levodopa-resistant parkinsonism has been reported in the Caribbean island of Guadeloupe. These seminal observations have not been replicated or extended to neighbouring populations who share genetic and environmental characteristics. METHODS: To further characterise this atypical parkinsonism we prospectively investigated 305 consecutive patients with neurodegenerative parkinsonism in a community-based population from Guadeloupe and Martinique, a neighbouring French Caribbean island where the population has similar environmental and genetic backgrounds...
May 15, 2018: Journal of the Neurological Sciences
Jessica Dully, David P McGovern, Redmond G O'Connell
It is well established that natural aging negatively impacts on a wide variety of cognitive functions and research has sought to identify core neural mechanisms that may account for these disparate changes. A central feature of any cognitive task is the requirement to translate sensory information into an appropriate action - a process commonly known as perceptual decision making. While computational, psychophysical, and neurophysiological research has made substantial progress in establishing the key computations and neural mechanisms underpinning decision making, it is only relatively recently that this knowledge has begun to be applied to research on aging...
February 10, 2018: Behavioural Brain Research
Jo-Anne Bright, Rebecca Richards, Maarten Kruijver, Hannah Kelly, Catherine McGovern, Alan Magee, Andrew McWhorter, Anne Ciecko, Brian Peck, Chase Baumgartner, Christina Buettner, Scott McWilliams, Claire McKenna, Colin Gallacher, Ben Mallinder, Darren Wright, Deven Johnson, Dorothy Catella, Eugene Lien, Craig O'Connor, George Duncan, Jason Bundy, Jillian Echard, John Lowe, Joshua Stewart, Kathleen Corrado, Sheila Gentile, Marla Kaplan, Michelle Hassler, Naomi McDonald, Paul Hulme, Rachel H Oefelein, Shawn Montpetit, Melissa Strong, Sarah Noël, Simon Malsom, Steven Myers, Susan Welti, Tamyra Moretti, Teresa McMahon, Thomas Grill, Tim Kalafut, MaryMargaret Greer-Ritzheimer, Vickie Beamer, Duncan A Taylor, John S Buckleton
We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing...
May 2018: Forensic Science International. Genetics
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