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Isoflavones

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https://www.readbyqxmd.com/read/28095349/anti-inflammatory-effects-of-ononin-on-lipopolysaccharide-stimulated-raw-264-7-cells
#1
Lin Dong, Lei Yin, Yuanbin Zhang, Xueyan Fu, Jincai Lu
Increasing evidence has shown that ononin, a major isoflavone, has anti-inflammatory effects on lipopolysaccharide (LPS)-induced inflammation. However, the molecular mechanisms underlying the anti-inflammatory effects of ononin are still unclear. In the present study, we investigated these effects and the underlying mechanisms of ononin on LPS-induced inflammatory responses. Mouse RAW 264.7 cells were treated with 1μg/mL LPS and 5, 25, 50, 100 or 150μM ononin for 18h. Cell viability was assessed using MTT assays, and the production of nitric oxide (NO), prostaglandin E2 (PGE2) and the pro-inflammatory cytokines TNF-α, IL-1β and IL-6 in cultures was examined by Griess and ELISA analyses...
January 14, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28091359/phyto-oestrogens-and-colorectal-cancer-risk-a-systematic-review-and-dose-response-meta-analysis-of-observational-studies
#2
Ruijingfang Jiang, Akke Botma, Anja Rudolph, Anika Hüsing, Jenny Chang-Claude
Epidemiological studies suggest that soya consumption as a source of phyto-oestrogens and isoflavones may be associated with a reduced risk of colorectal cancer. However, findings have not yet been synthesised for all groups of phyto-oestrogens. A meta-analysis was conducted to quantify the association between phyto-oestrogens and colorectal cancer risk. Relevant observational studies published up to June 2016 were identified by searching MEDLINE, EMBASE and Cochrane Library databases. Study-specific relative risks (RR) were pooled in both categorical and dose-response meta-analyses...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/28078844/a-natural-formula-containing-lactoferrin-equisetum-arvensis-soy-isoflavones-and-vitamin-d3-modulates-bone-remodeling-and-inflammatory-markers-in-young-and-aged-rats
#3
L Menghini, C Ferrante, L Leporini, L Recinella, A Chiavaroli, S Leone, G Pintore, M Vacca, G Orlando, L Brunetti
A pivotal role in osteoporosis development is played by radical oxygen species (ROS), the increased production of which is related to inhibited osteoblastic activity and bone formation. A new field of research could involve medicinal plants with antioxidant and protective effects in osteoporosis. Furthermore, considering the multifactorial metabolic aspects of osteoporosis, the pharmacological association of multiple medicinal plants could improve patient response. The aim of the present study is to evaluate in vitro and in vivo the protective effects of a natural formula containing lactoferrin 12%, Equisetum arvensis ES 54%, soy isoflavones 34% and vitamin D3 0...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28077306/the-interaction-of-dietary-isoflavones-and-estradiol-replacement-on-behavior-and-brain-derived-neurotrophic-factor-in-the-ovariectomized-rat
#4
Ashley L Russell, Jamie Moran Grimes, Darwin O Larco, Danette F Cruthirds, Joanna Westerfield, Lawren Wooten, Margaret Keil, Michael J Weiser, Michael R Landauer, Robert J Handa, T John Wu
Phytoestrogens are plant derived, non-steroidal compounds naturally found in rodent chows that potentially have endocrine-disrupting effects. Isoflavones, the most common phytoestrogens, have a similar structure and molecular weight to 17β-estradiol (E2) and have the ability to bind and activate both isoforms of the estrogen receptor (ER). Most isoflavones have a higher affinity for ERβ, which is involved in sexually dimorphic behavioral regulation. The goal of this study was to examine the interaction of isoflavones and E2 presence in the OVX rat on anxiety- and depressive- like behavior and the related BDNF pathophysiology...
January 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28069115/metabolism-variation-and-better-storability-of-dark-versus-light-coloured-soybean-glycine-max-l-merr-seeds
#5
Jiang Liu, Wen-Ting Qin, Hai-Jun Wu, Cai-Qiong Yang, Jun-Cai Deng, Nasir Iqbal, Wei-Guo Liu, Jun-Bo Du, Kai Shu, Feng Yang, Xiao-Chun Wang, Tai-Wen Yong, Wen-Yu Yang
The effects of storage duration on the seed germination and metabolite profiling of soybean seeds with five different coloured coats were studied. Their germination, constituents and transcript expressions of isoflavones and free fatty acids (FFAs) were compared using chromatographic metabolomic profiling and transcriptome sequencing. The seed water content was characterized using nuclear magnetic resonance (NMR) relaxometry. Results showed that dark-coloured seeds were less inactivated than light-coloured seeds...
May 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28067550/association-between-consumption-of-soy-and-risk-of-cardiovascular-disease-a-meta-analysis-of-observational-studies
#6
Zhaoli Yan, Xinyue Zhang, Chunlin Li, Shouchun Jiao, Wenyao Dong
Background The relationships between dietary intake of soy foods and risk of cardiovascular disease are uncertain. The aims of this study were to evaluate and summarize the evidence on the association between consumption of soy and risk of cardiovascular disease (including stroke and coronary heart disease). Methods We systematically searched the MEDLINE and EMBASE databases from their inception up to 22 February 2016. We included only observational studies, and used random-effects models to calculate summary relative risks (SRRs) and 95% confidence intervals (CIs)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28067513/evolution-of-quantitative-measures-in-nmr-quantum-mechanical-qhnmr-advances-chemical-standardization-of-a-red-clover-trifolium-pratense-extract
#7
Rasika S Phansalkar, Charlotte Simmler, Jonathan Bisson, Shao-Nong Chen, David C Lankin, James B McAlpine, Matthias Niemitz, Guido F Pauli
Chemical standardization, along with morphological and DNA analysis ensures the authenticity and advances the integrity evaluation of botanical preparations. Achievement of a more comprehensive, metabolomic standardization requires simultaneous quantitation of multiple marker compounds. Employing quantitative (1)H NMR (qHNMR), this study determined the total isoflavone content (TIfCo; 34.5-36.5% w/w) via multimarker standardization and assessed the stability of a 10-year-old isoflavone-enriched red clover extract (RCE)...
January 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28066099/genistein-synergizes-centchroman-action-in-human-breast-cancer-cells
#8
Shweta Kaushik, Hari Shyam, Ramesh Sharma, Anil K Balapure
OBJECTIVES: Despite the progress in the diagnosis and treatment of breast cancer, it remains a major health problem in women. Natural flavones along with chemotherapeutic agents enhance therapeutic response and minimize toxicity of chemical agents. Centchroman (CC) colloquially called as ormeloxifene, is a nonsteroidal oral contraceptive categorized as selective estrogen receptor modulator with anti-breast cancer activity. Genistein (GN), an isoflavone found mainly in soy products possesses anti-cancerous potential against a number of cancers including breast...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28055130/effect-of-biochanin-a-on-corn-grain-zea-mays-fermentation-by-bovine-rumen-amylolytic-bacteria
#9
Brittany E Harlow, Michael D Flythe, Glen E Aiken
AIMS: The objective was to determine the effect of biochanin A (BCA), an isoflavone produced by red clover (Trifolium pratense L.), on corn fermentation by rumen microorganisms. METHODS AND RESULTS: When bovine rumen bacterial cell suspensions (n = 3) were incubated (24 h, 39 °C) with ground corn, amylolytic bacteria including group D Gram-positive cocci (GPC; Streptococcus bovis; enterococci) proliferated, cellulolytic bacteria were inhibited, lactate accumulated, and pH declined...
January 5, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28054996/production-and-anti-melanoma-activity-of-methoxyisoflavones-from-the-biotransformation-of-genistein-by-two-recombinant-escherichia-coli-strains
#10
Chien-Min Chiang, Yu-Jhe Chang, Jiumn-Yih Wu, Te-Sheng Chang
Biotransformation of the soy isoflavone genistein by sequential 3'-hydroxylation using recombinant Escherichia coli expressing tyrosinase from Bacillus megaterium and then methylation using another recombinant E. coli expressing O-methyltransferase from Streptomyces peucetius was conducted. The results showed that two metabolites were produced from the biotransformation, identified as 5,7,4'-trihydroxy-3'-methoxyisoflavone and 5,7,3'-trihydroxy-4'-methoxyisoflavone, respectively, based on their mass and nuclear magnetic resonance spectral data...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28054950/microbial-glycosylation-of-daidzein-genistein-and-biochanin-a-two-new-glucosides-of-biochanin-a
#11
Sandra Sordon, Jarosław Popłoński, Tomasz Tronina, Ewa Huszcza
Biotransformation of daidzein, genistein and biochanin A by three selected filamentous fungi was investigated. As a result of biotransformations, six glycosylation products were obtained. Fungus Beauveria bassiana converted all tested isoflavones to 4″-O-methyl-7-O-glucosyl derivatives, whereas Absidia coerulea and Absidia glauca were able to transform genistein and biochanin A to genistin and sissotrin, respectively. In the culture of Absidia coerulea, in addition to the sissotrin, the product of glucosylation at position 5 was formed...
January 3, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28054115/-risk-and-benefit-of-nutritional-supplements-for-the-treatment-of-postmenopausal-complaints
#12
Patrick Diel, Anne Kurrat, Christina Oden, Lars Hanke
Menopause is for many females associated with an occurrence of a variety of health complaints and a decrease in quality in life. Hot flashes, sleep disturbances and a variety of other symptoms result in a strong psychological strain. Hormone replacement therapy for treatment of climacteric complaints is discussed controversially regarding associated side effects. This is a major reason to propose treatment with plant derived extracts and compounds as an alternative. Such compounds are available either as drugs but mostly as nutritional supplements...
January 4, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28053960/protective-effect-of-an-isoflavone-tectorigenin-against-oxidative-stress-induced-cell-death-via-catalase-activation
#13
Rui Zhang, Mei Jing Piao, Min Chang Oh, Jeong Eon Park, Kristina Shilnikova, Yu Jin Moon, Dong Hyun Kim, Uhee Jung, In Gyu Kim, Jin Won Hyun
BACKGROUND: Isoflavones are biologically active compounds that occur naturally in a variety of plants, with relatively high levels in soybean. Tectorigenin, an isoflavone, protects against hydrogen peroxide (H2O2)-induced cell damage. However, the underlying mechanism is unknown. METHODS: The MTT assay was performed to determine cell viability. Catalase activity was assessed by determining the amount of enzyme required to degrade 1 μM H2O2. Protein expression of catalase, phospho-extracellular signal-regulated kinase (ERK), IκB-α, and NF-κB were evaluated by Western blot analysis...
December 2016: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28053825/bioactive-flavonoids-and-catechols-as-hif1-and-nrf2-protein-stabilizers-implications-for-parkinson-s-disease
#14
Natalya A Smirnova, Navneet Ammal Kaidery, Dmitry M Hushpulian, Ilay I Rakhman, Andrey A Poloznikov, Vladimir I Tishkov, Saravanan S Karuppagounder, Irina N Gaisina, Anton Pekcec, Klaus Van Leyen, Sergey V Kazakov, Lichuan Yang, Bobby Thomas, Rajiv R Ratan, Irina G Gazaryan
Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase activation. To reveal specific structural requirements for direct stabilization of the transcription factors responsible for triggering the antihypoxic and antioxidant programs, we studied flavones, isoflavones and catechols including dihydroxybenzoate, didox, levodopa, and nordihydroguaiaretic acid (NDGA), using novel luciferase-based reporters specific for the first step in HIF1 or Nrf2 protein stabilization...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28041654/effects-of-dietary-soybean-isoflavones-si-on-reproduction-in-the-young-breeder-rooster
#15
Dai Heng, Tao Zhang, Ye Tian, Shangyu Yu, Wenbo Liu, Kaili Xu, Juan Liu, Yu Ding, Baochang Zhu, Yanzhou Yang, Cheng Zhang
Soybean isoflavones (SIs) are phytoestrogens that competitive with estrogens in body. Although SIs play an important role in reproduction, their role in testicular development in roosters is unknown. This study was conducted to investigate the effect of SIs on testicular development and serum reproductive hormone profiles in young breeder roosters (70-133days old). Gene expression of steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme (P450scc), and 3β-hydroxysteroid dehydrogenase (3β-HSD), which are related to testosterone synthesis, in rooster testis were also evaluated after treatment with different SI doses...
December 26, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/28041561/changes-in-equol-and-major-soybean-isoflavone-contents-during-processing-and-storage-of-yogurts-made-from-control-or-isoflavone-enriched-bovine-milk-determined-using-lc-ms-tof-analysis
#16
Jitka Kašparovská, Kateřina Dadáková, Jan Lochman, Sylvie Hadrová, Ludmila Křížová, Tomáš Kašparovský
The effect of supplementing a basal diet for dairy cows with "Soybean extract 40" (Biomedica, Prague, Czech Republic), containing 40% soybean isoflavones, on the contents of daidzein, glycitein, genistein, and equol in milk as well as fresh and mature yogurts was estimated. To determine the contents of these isoflavonoids, an efficient analytical LC-MS (TOF) technique was used. The "Soybean extract 40" used in our study contained an especially high proportion of daidzein (307gkg(-1)). In both milk and yogurt samples, the amounts of daidzein and its metabolite equol were significantly higher in samples obtained from cows that received the isoflavone extract-supplemented diet than from those that received the basal diet, as the precursor daidzein contributed to the increased equol concentrations...
May 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28029692/isoflavin-beta-modifies-muscle-oxidative-stress-and-prevents-a-thyrotoxicosis-induced-loss-of-muscle-mass-in-rats
#17
Poliana C Marinello, Sara S Bernardes, Flávia A Guarnier, Thamara N X da Silva, Fernando H Borges, Natália M D Lopes, Andréa N C Simão, André Armani, Rubens Cecchini, Alessandra L Cecchini
: Introduction We sought to verify whether Isoflavin-beta (Iso-β), a mixture of isoflavones with antioxidant properties could prevent thyrotoxicosis-induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention. METHODS: Two experimental periods of thyrotoxicosis induction were used in Wistar rats: 3 and 5 days to assess Iso-β effects before and after thyrotoxicosis-induced muscle wasting. After euthanasia, peritoneal fat and gastrocnemius muscle were collected, weighed, and muscle OS was assessed...
December 28, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/28025893/isoflavones-from-maclura-pomifera-structural-elucidation-and-in-silico-evaluation-of-their-interaction-with-pde5
#18
Giovanni Ribaudo, Tiziano Vendrame, Sergio Bova
While osajin and pomiferin are known for their anticancer, antibacterial and antidiabetic properties, scandenone and auriculasin have been proposed as anti-inflammatory and antinociceptive agents. Curiously, these two couples of molecules are, from a chemical point of view, structural isomers which can all be extracted from Maclura pomifera. Although previous works described, separately, the isolation in reasonable amounts of the sole osajin/pomiferin couple or of scandenone/auriculasin, we report the extraction and characterization using direct spectral and chromatographical comparison of the four compounds...
December 27, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27996108/effect-of-reproductive-history-and-exogenous-hormone-use-on-cognitive-function-in-mid-and-late-life
#19
Roksana Karim, Ha Dang, Victor W Henderson, Howard N Hodis, Jan St John, Roberta D Brinton, Wendy J Mack
OBJECTIVES: To investigate the association between reproductive history indicators of hormonal exposure, including reproductive period, pregnancy, and use of hormonal contraceptives, and mid- and late-life cognition in postmenopausal women. DESIGN: Analysis of baseline data from two randomized clinical trials: the Women's Isoflavone Soy Health and the Early vs Late Intervention Trial of Estradiol. SETTING: University academic research center...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27990149/genistein-a-novel-anthocyanin-synthesis-promoter-that-directly-regulates-biosynthetic-genes-in-red-cabbage-in-a-light-dependent-way
#20
Na Zhang, Yan Qi, Hai-Jun Zhang, Xiaoyun Wang, Hongfei Li, Yantong Shi, Yang-Dong Guo
Genistein (GNT), an isoflavone, is used in the clinical treatment of various health disorders. GNT is found in primary food source plants and some medical plants. However, studies on the functions of GNT in plants are rarely reported. In this study, we demonstrated that GNT plays an important role in promoting anthocyanin accumulation in red cabbage. GNT solutions (10, 20, 30, 40, and 50 mg/L) as foliar fertilizers were applied to red cabbage. Consequently, anthocyanin accumulation in red cabbage increased in a light-dependent manner...
2016: Frontiers in Plant Science
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