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T Sathyapalan, M Aye, A S Rigby, W D Fraser, E S Kilpatrick, S L Atkin
Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementation on BTM in T2DM and particularly in men is unclear. We performed an analysis of a randomized double blind parallel study of 200 men with T2DM treated with soy, either with or without isoflavones. Outcome measures were type I collagen crosslinked beta C-telopeptide (βCTX), and type 1 procollagen-N-propeptide (P1NP)...
November 13, 2017: Scientific Reports
Zhaoju Dong, Yanan Shi, Huijuan Zhao, Ning Li, Liang Ye, Shuping Zhang, Haibo Zhu
BACKGROUND: Sodium formononetin-3'-sulphonate (Sul-F) is a derivative of the isoflavone formononetin. In this study, we investigated whether Sul-F can regulate angiogenesis and the potential mechanism in vitro. METHODS: We examined the effects of Sul-F on cell proliferation, cell invasion, and tube formation in the human umbilical vein endothelial cell line (HUVEC). To better understand the mechanism involved, we investigated effects of the following compounds: cAMP response element-binding protein (CREB) inhibitor 2-naphthol-AS-E-phosphate (KG-501), early growth response 3 (Egr-3) siRNA, vascular endothelial growth factor (VEGF) antagonist soluble VEGF receptor 1 (sFlt-1), VEGF receptor 2 blocker SU-1498, Wnt5a antagonist WIF-1 recombinant protein (WIF-1), and inhibitor of Wnt/β-catenin recombinant Dickkopf-1 protein (DKK-1)...
October 31, 2017: Pharmacology
Luis E Simental-Mendía, Antonio M Gotto, Stephen L Atkin, Maciej Banach, Matteo Pirro, Amirhossein Sahebkar
BACKGROUND: Soy supplementation has been shown to reduce total and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol. However, contradictory effects of soy isoflavone supplementation on lipoprotein(a) [Lp(a)] have been reported suggesting the need for a meta-analysis to be undertaken. OBJECTIVE: The aim of the study was to investigate the impact of supplementation with soy isoflavones on plasma Lp(a) levels through a systematic review and meta-analysis of eligible randomized placebo-controlled trials...
October 17, 2017: Journal of Clinical Lipidology
Danka Bukvički, Miroslav Novaković, Nurunajah Ab Ghani, Petar D Marin, Yoshinori Asakawa
This manuscript describes the first detailed chemical investigation of endemic species Iris adriatica, including isolation and structure elucidation. Chemical analyses of the rhizome CH2Cl2/MeOH (2:1) extract revealed fourteen secondary metabolites, mainly isoflavonoids. Among isoflavonoids, two groups have been found: nigricin-type and tectorigenin-type. Dominant group of the isolated compounds has been nigricin-type isoflavones: nigricin, nigricin-4'-(1-O-β-D-glucopyranoside) and nigricin-4'-(1-O-β-D-glucopyranosyl (1-6)-β-D-glucopyranoside) with 2...
November 10, 2017: Natural Product Research
Wenya Zheng, Jana Rogoschin, Anja Niehoff, Kristina Oden, Sabine E Kulling, Mingyong Xie, Patrick Diel
The purpose of this study was to investigate the combinatory effects of an isoflavone (ISO)-rich diet and exercise on fat mass and lipid metabolism in ovariectomized (OVX) rats. Therefore the female Wistar rats were sedentary, performed an intense treadmill uphill running, received ISOs, or a combination of ISOs and running after ovariectomy. The exercise reduced visceral fat mass, adipocyte size and serum leptin in Sham animals and antagonized the increases of these parameters induced by OVX. ISOs reduced OVX induced increase of serum leptin...
November 6, 2017: Journal of Steroid Biochemistry and Molecular Biology
Yuchi Zhang, Yan He, Chengyu Liu, Chunming Liu, Sainan Li
Ultrafiltration liquid chromatography with mass spectrometry can efficiently and rapidly screen and identify ligands from the seeds of Cicer arietinum for human aromatase. Using this method, we identified 11 major compounds, including organic acids, organic acid glycosides, flavone glycosides, isoflavones, and isoflavone glycosides, as potent human aromatase inhibitors. A continuous online method, including pressurized liquid extraction, countercurrent chromatography, and preparative liquid chromatography, was developed for scaling up the production of these compounds with high purity and efficiency...
November 8, 2017: Journal of Separation Science
Michael K Reger, Terrell W Zollinger, Ziyue Liu, Josette F Jones, Jianjun Zhang
Experimental studies have revealed that phytoestrogens may modulate the risk of certain sites of cancer due to their structural similarity to 17β-estradiol. The present study investigates whether intake of these compounds may influence prostate cancer risk in human populations. During a median follow up of 11.5 years, 2,598 cases of prostate cancer (including 287 advanced cases) have been identified among 27,004 men in the intervention arm of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
November 8, 2017: International Journal of Cancer. Journal International du Cancer
Brittany E Harlow, Michael D Flythe, Glen E Aiken
AIMS: The objective was to determine the effect of the isoflavone biochanin A (BCA) on rumen cellulolytic bacteria and consequent fermentative activity. METHODS AND RESULTS: When bovine microbial rumen cell suspensions (n = 3) were incubated (24 h, 39 °C) with ground hay, cellulolytic bacteria proliferated, short chain fatty acids were produced and pH declined. Biochanin A (30 μg mL(-1) ) had no effect on the number of cellulolyic bacteria or pH, but increased acetate, propionate and total SCFA production...
November 7, 2017: Journal of Applied Microbiology
Seyed-Mohamad-Sadegh Mirahmadi, Alireza Shahmohammadi, Ali-Mohammad Rousta, Mohammad-Reza Azadi, Javad Fahanik-Babaei, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Systemic inflammation during infectious disorders usually accompanies chronic complications including cognitive dysfunction. Neuroinflammation and cognitive deficit are also observed in some debilitating neurological disorders like Alzheimer's and Parkinson's diseases. Genistein is a soy isoflavone with multiple beneficial effects including anti-inflammatory, anti-oxidative, and protective properties. In this research study, the effect of genistein in prevention of lipopolysaccharide (LPS)-induced cognitive dysfunction was investigated...
October 25, 2017: Cytokine
Juan Pablo Rigalli, Paul Niklas Scholz, Guillermo Nicolás Tocchetti, María Laura Ruiz, Johanna Weiss
PURPOSE: The soy isoflavone genistein has been described to up-regulate breast cancer resistance protein (BCRP) and, thus, enhance chemoresistance in breast cancer cells. The aim of this work was to assess the effect of long- and short-term incubation with daidzein, the second most abundant soy isoflavone and its metabolite equol on the expression and activity of P-glycoprotein, multidrug resistance-associated proteins 1 and 2 (MRP1 and MRP2) and BCRP in breast cancer cells. METHODS: MCF-7 and MDA-MB-231 cells were treated with phytoestrogen concentrations within the range achieved in individuals with a high isoflavone intake...
November 3, 2017: European Journal of Nutrition
Misaki Ono, Kaoru Ejima, Takako Higuchi, Mikako Takeshima, Rei Wakimoto, Shuji Nakano
Anticancer activities of soy isoflavones, such as genistein and equol, a bioactive metabolite of daidzein, have been extensively studied because of possible involvement in the prevention of breast cancer. However, their interactions still remain unclear. We investigated here whether cytotoxic activity of genistein was enhanced by equol, using estrogen receptor positive MCF-7, HER2-positive SK-BR-3, and triple-negative MDA-MB-468 cell lines. Although cytotoxicity of genistein did not significantly differ between three subtypes of breast cancer cells, cytotoxic activities of genistein were significantly enhanced in combination with 50 μM equol in MCF-7 cells, but not in SK-BR-3 and MDA-MB-468 cells...
November 2, 2017: Nutrition and Cancer
Vijay Kumar, Anchal Sharma, Shivendra Pratap, Pravindra Kumar
BACKGROUD: β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) is an essential component of type II fatty acid biosynthesis (FAS II) pathway in bacteria. It performs dehydration of β-hydroxyacyl-ACP to trans-2-acyl-ACP in the elongation cycle of the FAS II pathway. FabZ is ubiquitously expressed and has uniform distribution, which makes FabZ an excellent target for developing novel drugs against pathogenic bacteria. METHODS: We focused on the biochemical and biophysical characterization of FabZ from drug-resistant pathogen Moraxella catarrhalis (McFabZ)...
October 29, 2017: Biochimica et Biophysica Acta
Adriana Aparecida Ferraz Carbonel, Patrícia Daniele Azevedo Lima, Jung Jin Lim, Luiz Fernando Portugal Fuchs, Ana Paula Ribeiro Paiotti, Gisela Rodrigues da Silva Sasso, Ricardo Santos Simões, José Maria Soares Junior, Edmund Chada Baracat, Manuel de Jesus Simões
The objective of this study was to evaluate the action of soy isoflavones and 17 beta estradiol on the extracellular matrix in the uterus and mammary gland of diabetic rats. Sixty adult female rats underwent ovariectomy, then randomized into seven groups of ten animals each: Non-diabetic: GI Sham control animals ovariectomized; and GII control ovariectomized that received propylene glycol vehicle. Diabetic: GIII Sham control diabetic animals ovariectomized; GIV ovariectomized diabetic animals receiving propylene glycol vehicle; GV diabetic ovariectomized animals treated with soy isoflavones (150 mg/kg by gavage); GVI ovariectomized diabetic rats treated with estrogen (17b-estradiol, 10 mg/kg, subcutaneously); GVII diabetic ovariectomized animals treated with soy isoflavones (150 mg/kg by gavage), and with estrogen (17b-estradiol, 10 mg/kg combination therapy)...
November 2, 2017: Gynecological Endocrinology
Delphine Parrot, Laurent Intertaglia, Philippe Jehan, Martin Grube, Marcelino T Suzuki, Sophie Tomasi
Alphaproteobacterium strain MOLA1416, related to Mycoplana ramosa DSM 7292 and Chelativorans intermedius CC-MHSW-5 (93.6% 16S rRNA sequence identity) was isolated from the marine lichen, Lichina pygmaea and its chemical composition was characterized by a metabolomic network analysis using LC-MS/MS data. Twenty-five putative different compounds were revealed using a dereplication workflow based on MS/MS signatures available through GNPS ( In total, ten chemical families were highlighted including isocoumarins, macrolactones, erythrinan alkaloids, prodiginines, isoflavones, cyclohexane-diones, sterols, diketopiperazines, amino-acids and most likely glucocorticoids...
October 29, 2017: Phytochemistry
Dan Tang, Ying-Bin Shen, Zhi-Hua Wang, Bao He, You-Hua Xu, Hong Nie, Quan Zhu
Isoflavonoids including isoflavones, isoflavans and pterocarpans, the principal components in Astragalus membranaceus, have a great deal of versatile health-promoting benefits. In this work, as a continuation of our searching for bioactive constituents from A. membranaceus, a fast UHPLC-DAD-MSn method was firstly used to analyze the isoflavonoids profile of A. membranaceus roots extract. Twelve diverse isoflavonoids with subclass of isoflavones, isoflavans and pterocarpans occurred in glycoside/aglycone pairs forms were tentatively characterized, of them eight major isoflavonoids were finally isolated guided and simultaneously quantified by the established fast UHPLC method...
November 1, 2017: Journal of Agricultural and Food Chemistry
Jeong Eun Kwon, Jin Woo Lee, Yuna Park, Eun-Hwa Sohn, Eui Su Choung, Seon-A Jang, Inhye Kim, Da Eun Lee, Hyun Jung Koo, Jong Phil Bak, Sung Ryul Lee, Se Chan Kang
Isoflavone itself is less available in the body without the aid of intestinal bacteria. In this study, we searched the isoflavone transforming bacterium from human fecal specimen (n=14) using differential selecting media. Isoflavone transforming activity as the production of dihydrogenistein (DHG) and dihydrodaidzein (DHD) was assessed by high performance liquid chromatography and found Lactobacillus rhamnosus, named L. rhamnosus vitaP1 through 16s rDNA sequence analysis. Extract from Pueraria lobata (EPL) and Soy hypocotyl extract were fermented with L...
October 30, 2017: Journal of Microbiology and Biotechnology
Edyta Kostrzewa-Susłow, Monika Dymarska, Urszula Guzik, Danuta Wojcieszyńska, Tomasz Janeczko
A group of flavones, isoflavones, flavanones, and chalcones was subjected to small-scale biotransformation studies with the Gram-negative Stenotrophomonas maltophilia KB2 strain in order to evaluate the capability of this strain to transform flavonoid compounds and to investigate the relationship between compound structure and transformation type. The tested strain transformed flavanones and chalcones. The main type of transformation of compounds with a flavanone moiety was central heterocyclic C ring cleavage, leading to chalcone and dihydrochalcone structures, whereas chalcones underwent reduction to dihydrochalcones and cyclisation to a benzo-γ-pyrone moiety...
October 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Youngyo Kim, Youjin Je
BACKGROUND AND AIMS: Accumulating studies have suggested that flavonoid intake is associated with a decreased risk of coronary heart disease and cardiovascular disease (CVD). There are many epidemiological studies on flavonoid intake and mortality, but no comprehensive investigation has yet been conducted. To quantitatively assess the association between flavonoid intake and mortality from CVD and all-causes, we performed a meta-analysis of prospective cohort studies. METHODS: Eligible studies were identified by searching PubMed and Web of Science databases for all articles published up to May 2016 and via hand searching...
August 2017: Clinical Nutrition ESPEN
Vidya Mukund, Dhruv Mukund, Vinay Sharma, Mastan Mannarapu, Afroz Alam
Genistein is an isoflavone present in soy and is known to have multiple molecular effects, such as the inhibition of inflammation, promotion of apoptosis, and modulation of steroidal hormone receptors and metabolic pathways. Since these molecular effects impact carcinogenesis, cancer propagation, obesity, osteoporosis, and metabolic syndromes, genistein plays an important role in preventing and treating common disorders. The role of genistein has not been adequately evaluated in all these clinical settings...
November 2017: Critical Reviews in Oncology/hematology
Jiaoyu Wang, Ling Li, Yeshi Yin, Zhuokan Gu, Rongyao Chai, Yanli Wang, Guochang Sun
Equol, a metabolite of soybean isoflavone daidzein, has been proven to have various bioactivities related to human health, but little is known on its antifungal activity to plant fungal pathogens. Magnaporthe oryzae is a phytopathogenic fungus that causes rice blast, a devastating disease on rice. Here, we demonstrated that equol influences the development and pathogenicity of M. oryzae. Equol showed a significant inhibition to the mycelial growth, conidial generation and germination, and appressorial formation of M...
October 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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