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Isoflavones

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https://www.readbyqxmd.com/read/29329835/in-depth-chemical-investigation-of-glycyrrhiza-triphylla-fisch-roots-guided-by-a-preliminary-hplc-esimsn-profiling
#1
Abolfazl Shakeri, Milena Masullo, Gilda D'Urso, Mehrdad Iranshahi, Paola Montoro, Cosimo Pizza, Sonia Piacente
Chemical investigations on Glycyrrhiza spp. have mostly been focused on G. glabra (typically cultivated in Europe, henceforth called European licorice), G. uralensis and G. inflata (known as Chinese licorice) with little information on the constituents of other Glycyrrhiza species. According to the growing interest in further Glycyrrhiza spp. to be used as sweeteners, the roots of G. triphylla have been investigated. The LC-ESI/LTQOrbitrap/MS profile of the methanolic extract of G. triphylla roots guided the isolation of 21 compounds, of which the structures were elucidated by 1D- and 2D-NMR experiments...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329615/synthesis-and-cytotoxicity-evaluation-of-3-amino-2-hydroxypropoxygenistein-derivatives
#2
Xiao-Ting Geng, Jing-Jing Tang, Kun-Peng Cheng, Yuan-Tao Fu, Rong Hu, Jin-Rong Lu
Soy isoflavones exhibit various biological activities, such as antioxidant, anti-tumor, anti-inflammatory, and cardiovascular protective effects. The present study was designed to investigate the effects of sixteen synthesized 3-amino-2-hydroxypropoxy genistein derivatives on cell proliferation and activation of Nrf2 (Nuclear factor erythroid 2-related factor 2)/ARE (antioxidant response elements) pathway in human cancer cell lines. Most of the tested compounds exerted greater cytotoxic activity than genistein, as measured by MTT assay...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329272/rapid-screening-and-identification-of-daidzein-metabolites-in-rats-based-on-uhplc-ltq-orbitrap-mass-spectrometry-coupled-with-data-mining-technologies
#3
Wenjing Zhao, Zhanpeng Shang, Qinqing Li, Moran Huang, Wenbin He, Zhibin Wang, Jiayu Zhang
Daidzein, the main bioactive soy isoflavone in Nature, has been found to possess many biological functions. It has been investigated in particular as a phytoestrogen owing to the similarity of its structure with that of the human hormone estrogen. Due to the lack of comprehensive studies on daidzein metabolism, further research is still required to clarify its in vivo metabolic fate and intermediate processes. In this study, an efficient strategy was established using UHPLC-LTQ-Orbitrap mass spectrometry to profile the metabolism of daidzein in rats...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29327296/correction-to-dietary-intake-of-soy-and-cruciferous-vegetables-and-treatment-related-symptoms-in-chinese-american-and-non-hispanic-white-breast-cancer-survivors
#4
Sarah J O Nomura, Yi-Ting Hwang, Scarlett Lin Gomez, Teresa T Fung, Shu-Lan Yeh, Chiranjeev Dash, Laura Allen, Serena Philips, Leena Hilakivi-Clarke, Yun-Ling Zheng, Judy Huei-Yu Wang
In the original publication, the values provided for the isoflavone and glucosinolate intake variables were incorrectly labeled in Table 1. The correct values of 6.3 mg/day for isoflavone intake, and 20.4 mg/day and 50.1 mg/day for glucosinolate intake are provided in this erratum.
January 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29305928/anti-proliferative-activity-of-biochanin-a-in-human-osteosarcoma-cells-via-mitochondrial-involved-apoptosis
#5
Yen-Nien Hsu, Huey-Wen Shyu, Tsui-Wen Hu, Jou-Pei Yeh, Ya-Wen Lin, Ling-Yi Lee, Yao-Tsung Yeh, Hong-Ying Dai, Daw-Shyong Perng, Shu-Hui Su, Yu-Hsuan Huang, Shu-Jem Su
Biochanin A is a major isoflavone in red clover and a potent chemopreventive agent against cancer. However, the effects of biochanin A on human osteosarcoma cells have never been clarified. This study investigated the anti-proliferative potential of biochanin A in osteosarcoma cells. The results indicate that biochanin A inhibited cell growth and colony formation in a dose-dependent manner with a minimal toxicity to normal cells. The combination of doxorubicin and biochanin A could synergistically inhibit osteosarcoma cell growth...
January 3, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29304010/soy-soy-foods-and-their-role-in-vegetarian-diets
#6
REVIEW
Gianluca Rizzo, Luciana Baroni
Soy is a basic food ingredient of traditional Asian cuisine used for thousands of years. In Western countries, soybeans have been introduced about a hundred years ago and recently they are mainly used for surrogate foods production. Soy and soy foods are common nutritional solutions for vegetarians, due to their high protein content and versatility in the production of meat analogues and milk substitutes. However, there are some doubts about the potential effects on health, such as the effectiveness on cardiovascular risk reduction or, conversely, on the possible disruption of thyroid function and sexual hormones...
January 5, 2018: Nutrients
https://www.readbyqxmd.com/read/29300347/soy-consumption-and-the-risk-of-prostate-cancer-an-updated-systematic-review-and-meta-analysis
#7
REVIEW
Catherine C Applegate, Joe L Rowles, Katherine M Ranard, Sookyoung Jeon, John W Erdman
Prostate cancer (PCa) is the second most commonly diagnosed cancer in men, accounting for 15% of all cancers in men worldwide. Asian populations consume soy foods as part of a regular diet, which may contribute to the lower PCa incidence observed in these countries. This meta-analysis provides a comprehensive updated analysis that builds on previously published meta-analyses, demonstrating that soy foods and their isoflavones (genistein and daidzein) are associated with a lower risk of prostate carcinogenesis...
January 4, 2018: Nutrients
https://www.readbyqxmd.com/read/29287388/effects-of-salinity-on-bacterial-communities-maillard-reactions-isoflavone-composition-antioxidation-and-antiproliferation-in-korean-fermented-soybean-paste-doenjang
#8
Mi Jeong Kim, Han Sub Kwak, Sang Sook Kim
The purpose of this study was to investigate bacterial communities and health-benefit-related parameters in doenjang prepared with various brine concentrations (8, 12, 16, and 20%). Phenolic, flavonoid, melanoidin and isoflavone contents, antioxidation, and antiproliferation of doenjang (AD8, AD12, AD16, and AD20) aged for 3 months were compared with those of initial doenjang (ID8, ID12, ID16, and ID20). The ID8 and AD8 doenjang, made with 8% brine, contained higher phenolics, melanoidins, and isoflavones than those with high salinity...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29287378/evaluation-of-estrogenic-activity-of-red-clover-trifolium-pratense-l-sprouts-cultivated-under-different-conditions-by-content-of-isoflavones-calorimetric-study-and-molecular-modelling
#9
Grażyna Budryn, Ilona Gałązka-Czarnecka, Ewelina Brzozowska, Joanna Grzelczyk, Radosław Mostowski, Dorota Żyżelewicz, José P Cerón-Carrasco, Horacio Pérez-Sánchez
Isoflavones have an affinity for estrogen receptors (ERs) including beneficial affinity for ERβ. Widely used soy is a source of poorly absorbed isoflavones glycosides. Red clover contains mostly easily absorbed free aglycones. Red clover sprouts were cultivated under different conditions (white light, UVA or UVB for 12 or 24 h a day at 18 or 25 °C) to maximise the content of isoflavones, especially of high affinity for ERβ. The affinity of isoflavones to ERs was evaluated by molecular modelling and isothermal titration calorimetry (ITC)...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29281341/functional-foods-and-nutraceuticals-as-dietary-intervention-in-chronic-diseases-novel-perspectives-for-health-promotion-and-disease-prevention
#10
Stephen Adeniyi Adefegha
Functional foods describe the importance of foods in promoting health and preventing diseases aside their primary role of providing the body with the required amount of essential nutrients such as proteins, carbohydrates, vitamins, fats, and oils needed for its healthy survival. This review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-I converting enzyme [ACE], acetylcholinesterase [AChE], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [Alzheimer's disease] and erectile dysfunction)...
December 27, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29277346/dietary-isoflavones-or-isoflavone-rich-food-intake-and-breast-cancer-risk-a-meta-analysis-of-prospective-cohort-studies
#11
Ting-Ting Zhao, Feng Jin, Ji-Guang Li, Ying-Ying Xu, Hui-Ting Dong, Qun Liu, Peng Xing, Guo-Lian Zhu, Hao Xu, Zhi-Feng Miao
BACKGROUND & AIMS: Previous studies implied that dietary isoflavone intake may reduce the risk of developing breast cancer, but some have shown ambiguous results. This study aimed to systematically evaluate and summarize available evidence on the effect dietary isoflavone intake has on the risk of developing breast cancer. METHODS: PubMed, Embase, and the Cochrane Library were searched for prospective cohort studies published through April 2017 that evaluated the effect of dietary isoflavone intake on the development of breast cancer...
December 15, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29261006/feeding-obese-diabetic-mice-a-genistein-diet-induces-thermogenic-and-metabolic-change
#12
Schuyler Rockwood, Tom L Broderick, Layla Al-Nakkash
Obesity is associated with elevated plasma levels of glucocorticoids and reduced levels of thyroid hormones, both known to effect food intake and energy expenditure. Furthermore, tissue specific glucocorticoid metabolism is altered in obesity, increasing insulin resistance and cardiometabolic risk. The goal of this study was to examine whether these metabolic disturbances can be prevented with the isoflavone genistein in the ob/ob mouse, a model that resembles the phenotype in human obesity. Male ob/ob mice, aged 5 weeks, were fed either a genistein-rich diet (600 mg/kg) or a genistein-free diet for 4 weeks...
December 20, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29250153/the-inhibitory-effects-of-soybean-isoflavones-on-testicular-cell-apoptosis-in-mice-with-type-2-diabetes
#13
Zhaojin Du, Zhilei Qiu, Zhankun Wang, Xinsheng Wang
The aim of the study was to investigate the inhibitory effects of soybean isoflavones (SI) on testicular cell apoptosis in mice with type-2 diabetes, as well as any possible mechanisms of action. Thirty male C57BL/6J mice were randomly divided into the control, diabetic (model), and treatment (SI) groups (n=10 each). After treatment for 20 weeks, testicular cell apoptosis was detected and evaluated using DAPI staining. The expression and distribution of caspase-3 protein in testicular tissues was detected via immunohistochemistry, while caspase-3 mRNA expression was detected using RT-PCR...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29249036/impact-of-diet-restriction-in-the-management-of-diabetes-evidences-from-preclinical-studies
#14
REVIEW
Pawan Krishan, Onkar Bedi, Monika Rani
The inappropriate dietary habits lead to the onset of age-related pathologies which include diabetes and cardiovascular ailments. Dietary restriction and nutritional therapy play an important role in the prevention of these chronic ailments. Preclinical research provides a basis for the therapeutic exploration of new dietary interventions for the clinical trials to potentiate the scientific management of diabetes and its related complications which further help in translating these nutritional improvements from bench to bedside...
December 16, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29241917/pueraria-mirifica-inhibits-17%C3%AE-estradiol-induced-cell-proliferation-of%C3%A2-human-endometrial-mesenchymal-stem-cells
#15
Ta-Chin Lin, Kai-Hung Wang, An-Pei Kao, Kuo-Hsiang Chuang, Tsung-Cheng Kuo
OBJECTIVE: The notion that the human endometrium may contain a population of stem cells has recently been proposed. The mesenchymal stem cells (MSCs) in the endometrium are believed to be responsible for the remarkable regenerative ability of endometrial cells. Estrogens influence the physiological and pathological processes of several hormone-dependent tissues, such as the endometrium. Pueraria mirifica (PM) is a herbal plant that contains several phytoestrogens, including isoflavones, lignans, and coumestans, and is known to exert an estrogenic effect on animal models...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29239462/isoflavones-derived-from-glycine-max-l-merr-in-the-treatment-of-vaginal-atrophy-a-new-frontier
#16
Sônia Maria Rolim Rosa Lima, Adriana Bittencourt Campaner, Antonio Pedro Flores Auge
No abstract text is available yet for this article.
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29238465/genistein-preserves-the-lungs-of-ovariectomized-diabetic-rats-addition-to-apoptotic-and-inflammatory-markers-in-the-lung
#17
Faeze Daghigh, Alireza Alihemmati, Pouran Karimi, Parisa Habibi, Naser Ahmadiasl
Objectives: The role of isoflavones in pulmonary structure and function during menopause is not well studied. Moreover, the important role of estrogen in the physiological function of respiratory system has been revealed. Genistein, as an isoflavone, mimics estrogenic in diabetic and ovariectomized rats. Here, we hypothesized that genistein would reverse changes in the protein expression levels related to estrogen deficiency in the lung of ovariectomized diabetic rats. Materials and Methods: Wistar female rats were assigned to four experimental groups (n=10 in each group): sham, rats underwent laparotomy without removing the ovaries; OVX, rats that underwent ovariectomy; OVX...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29236164/the-influence-of-isoflavone-for-denervation-induced-muscle-atrophy
#18
Shinpei Tabata, Miki Aizawa, Masakazu Kinoshita, Yoshinori Ito, Yusuke Kawamura, Minoru Takebe, Weijun Pan, Kunihiro Sakuma
PURPOSE: Decrease in activity stress induces skeletal muscle atrophy. A previous study showed that treatment with a high level (20%) of isoflavone inhibits muscle atrophy after short-term denervation (at 4 days) in mice. The present study was designed to elucidate whether the dietary isoflavone aglycone (AglyMax) at a 0.6% prevents denervation-mediated muscle atrophy, based on the modulation of atrogin-1- or apoptosis-dependent signaling. METHODS: Mice were fed either a normal diet or 0...
December 13, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29232930/effects-of-bacterial-fermentation-on-the-biochemical-constituents-and-antioxidant-potential-of-fermented-and-unfermented-soybeans-using-probiotic-bacillus-subtilis-kctc-13241
#19
Muhammad Waqas Ali, Il-Doo Kim, Saqib Bilal, Raheem Shahzad, Muhammad Tariq Saeed, Bishnu Adhikari, Rizwana Begum Syed Nabi, Jeong Rae Kyo, Dong-Hyun Shin
Fermented soybeans, cheonggukjang (CKJ), are considered to be more wholesome than soybeans in Korea. To select the best soybean cultivar for making functional CKJ, a comparison was made between the biological activities of four soybean cultivars in their unfermented soybean (UFS) and CKJ states. Changes in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, superoxide dismutase (SOD)-like activity, total phenolic compounds, total amino acids, and isoflavones were investigated...
December 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29231720/phosphorylation-of-isoflavone-by-bacillus-subtilis-bcrc-80517-may-represent-xenobiotic-metabolism
#20
Chen Hsu, Bo-Yuan Wu, Yu-Chuan Chang, Chi-Fon Chang, Tai-Ying Chiou, Nan-Wei Su
Soy isoflavones, daidzein (DAI) and genistein (GEN), have beneficial effects on human health. However, their oral bioavailability is hampered by low aqueous solubility. Our previous study revealed two water-soluble phosphorylated isoflavones conjugates of isoflavones, daidzein 7-O-phosphate and genistein 7-O-phosphate, generated by biotransformation of Bacillus subtilis BCRC80517 cultivated with isoflavones. In this study, two novel derivatives of isoflavones, daidzein 4'-O-phosphate and genistein 4'-O-phosphate, were identified by HPLC-ESI-MS/MS and 1H, 13C and 31P NMR and the biotransformation road map was proposed...
December 12, 2017: Journal of Agricultural and Food Chemistry
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