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Isoflavones

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https://www.readbyqxmd.com/read/28718678/discovery-of-novel-isoflavone-derivatives-as-ache-buche-dual-targeted-inhibitors-synthesis-biological-evaluation-and-molecular-modelling
#1
Bo Feng, Xinpeng Li, Jie Xia, Song Wu
AChE and BuChE are druggable targets for the discovery of anti-Alzheimer's disease drugs, while dual-inhibition of these two targets seems to be more effective. In this study, we synthesised a series of novel isoflavone derivatives based on our hit compound G from in silico high-throughput screening and then tested their activities by in vitro AChE and BuChE bioassays. Most of the isoflavone derivatives displayed moderate inhibition against both AChE and BuChE. Among them, compound 16 was identified as a potent AChE/BuChE dual-targeted inhibitor (IC50: 4...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28715285/dietary-daidzein-but-not-genistein-has-a-hypocholesterolemic-effect-in-non-ovariectomized-and-ovariectomized-female-sprague-dawley-rats-on-a-cholesterol-free-diet
#2
Keshab Bhattarai, Sudhashree Adhikari, Mina Fujitani, Taro Kishida
We compared the effects of two major isoflavones, daidzein and genistein, on lipid metabolism in rats. Daidzein (150 mg/kg diet), genistein (150 mg/kg diet), daidzein and genistein (1:1, 300 mg/kg diet), or control diets were fed to 4 groups of 6-week-old ovariectomized (Ovx) and non-Ovx Sprague Dawley rats for 4 weeks. Dietary daidzein, but not genistein, reduced serum and hepatic total cholesterol levels significantly relative to that by the control group, regardless of whether the rats had undergone ovariectomy...
July 17, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28713336/development-and-use-of-a-real-time-quantitative-pcr-method-for-detecting-and-quantifying-equol-producing-bacteria-in-human-faecal-samples-and-slurry-cultures
#3
Lucía Vázquez, Lucía Guadamuro, Froilán Giganto, Baltasar Mayo, Ana B Flórez
This work introduces a novel real-time quantitative PCR (qPCR) protocol for detecting and quantifying equol-producing bacteria. To this end, two sets of primers targeting the dihydrodaidzein reductase (ddr) and tetrahydrodaidzein reductase (tdr) genes, which are involved in the synthesis of equol, were designed. The primers showed high specificity and sensitivity when used to examine DNA from control bacteria, such as Slackia isoflavoniconvertens, Slackia equolifaciens, Asaccharobacter celatus, Adlercreutzia equolifaciens, and Enterorhabdus mucosicola...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712053/soy-isoflavone-consumption-and-age-at-pubarche-in-adolescent-males
#4
Gina Segovia-Siapco, Peter Pribis, Keiji Oda, Joan Sabaté
PURPOSE: Isoflavones have estrogenic properties that may adversely affect pubertal development of boys. We examined if soy isoflavone consumption is associated with age at pubarche (first onset of pubic hair) in a male population with a wide range of soy intake. METHODS: Boys aged 12-18 years (n = 248) who attended schools around Adventist universities in Southern California and Michigan self-reported their age at pubarche. Intake of soy isoflavones was assessed using a validated Web-based food frequency questionnaire; consumption levels were designated as low, moderate, and high...
July 15, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28698467/effect-of-soy-isoflavones-on-growth-of-representative-bacterial-species-from-the-human-gut
#5
Lucía Vázquez, Ana Belén Flórez, Lucía Guadamuro, Baltasar Mayo
The present work aimed to assess the susceptibility of dominant and representative bacterial populations from the human gut to isoflavones and their metabolites. To do so, the minimum inhibitory concentration (MIC) of isoflavone glycosides, isoflavone aglycones, and equol to 37 bacterial strains was determined by broth microdilution. Additionally, for 10 representative strains, growth curves, growth rate (μ), and optical density (OD600 nm) of the cultures at 24 h were also determined. MICs of daidzin, genistin, daidzein, and genistein were >2048 μg mL(-1) for all strains assayed, while that of equol ranged from 16 μg mL(-1) for Bifidobacterium animalis subsp...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28689509/formononetin-a-methoxy-isoflavone-enhances-bone-regeneration-in-a-mouse-model-of-cortical-bone-defect
#6
Krishna Bhan Singh, Manisha Dixit, Kapil Dev, Rakesh Maurya, Divya Singh
The bone regeneration and healing effect of formononetin was evaluated in a cortical bone defect model that predominantly heals by intramembranous ossification. For this study, female Balb/c mice were ovariectomised (OVx) and a drill-hole injury was generated in the midfemoral bones of all animals. Treatment with formononetin commenced the day after and continued for 21 d. Parathyroid hormone (PTH1-34) was used as a reference standard. Animals were killed at days 10 and 21. Femur bones were collected at the injury site for histomorphometry studies using microcomputed tomography (μCT) and confocal microscopy...
July 10, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28675204/effect-of-soybean-protein-on-blood-pressure-in-postmenopausal-women-a-meta-analysis-of-randomized-controlled-trials
#7
REVIEW
Tingyan Kou, Qiuzhen Wang, Jing Cai, Jiaqi Song, Baoli Du, Kun Zhao, Yan Ma, Bo Geng, Yu Zhang, Xiaohong Han, Menglu Jiang, Haiyan Guo, Baocui Hu, Zhaoying Li, Yaoyao Zhai, Chuan Zhang
The effect of soybean protein on blood pressure (BP) in postmenopausal women is controversial, so we aimed to conduct a systematic review and a meta-analysis of published randomized controlled trials (RCTs) to investigate whether supplementation with soy protein improves their blood pressure. PubMed and Embase were searched up to February 2016. Weighted mean differences were calculated for net changes in BP by using fixed-effect or random-effect models. Subgroup and meta-regression analyses were performed to clarify heterogeneity among the trials...
July 4, 2017: Food & Function
https://www.readbyqxmd.com/read/28674272/frequent-generation-of-mutants-with-coincidental-changes-in-multiple-traits-via-ion-beam-irradiation-in-soybean
#8
Shun Mikuriya, Megumi Kasai, Kenta Nakashima, Natasia, Yoshihiro Hase, Tetsuya Yamada, Jun Abe, Akira Kanazawa
Ion beams are powerful mutagens that can induce novel mutants in plants. We previously established a system for producing a mutant population of soybean via ion-beam irradiation, isolated plants that had chlorophyll deficiency, and maintained their progeny via self-fertilization. Here we report the characterization of the progeny plants in terms of chlorophyll content, flowering time and isoflavone content in seeds. Chlorophyll deficiency in the leaf tissues was linked with reduced levels of isoflavones, the major flavonoid compounds accumulated in soybean seeds, which suggested the involvement of metabolic changes associated with the chlorophyll deficiency...
June 30, 2017: Genes & Genetic Systems
https://www.readbyqxmd.com/read/28672925/dietary-soy-isoflavones-alleviate-dextran-sulfate-sodium-induced-inflammation-and-oxidative-stress-in-mice
#9
Bin Wang, Cunbing Wu
It has been hypothesized that soy isoflavones exhibit anti-oxidative and anti-inflammatory functions, however, the effects of soy isoflavones on inflammatory bowel diseases remain unknown. Therefore, the present study aimed to investigate the effect and underlying mechanism of dietary soy isoflavones on dextran sulfate sodium (DSS)-induced colitis. Mice were administered DSS and soy isoflavones, and histomorphometry, oxidative stress, inflammation and intestinal tight junctions were determined. The current study demonstrated that dietary soy isoflavones alleviated DSS-induced growth suppression, colonic inflammatory response, oxidative stress and colonic barrier dysfunction...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28666461/glyceollins-trigger-anti-proliferative-effects-through-estradiol-dependent-and-independent-pathways-in-breast-cancer-cells
#10
Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou, Farzad Pakdel
BACKGROUND: Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract. In addition to estradiol (E2), a natural hormone, numerous compounds are able to bind ERs and modulate their activities. Among these compounds, phytoestrogens such as isoflavones, which are found in plants, are promising therapeutics for several pathologies. Glyceollins are second metabolites of isoflavones that are mainly produced in soybean in response to an elicitor...
June 30, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28665590/isoflavones-and-rotenoids-from-the-leaves-of-millettia-oblata-ssp-teitensis
#11
Tsegaye Deyou, Makungu Marco, Matthias Heydenreich, Fangfang Pan, Amra Gruhonjic, Paul A Fitzpatrick, Andreas Koch, Solomon Derese, Jerry Pelletier, Kari Rissanen, Abiy Yenesew, Máté Erdélyi
A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography...
June 30, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28661316/effects-of-isoflavone-containing-soya-protein-on-ex-vivo-cholesterol-efflux-vascular-function-and-blood-markers-of-cvd-risk-in-adults-with-moderately-elevated-blood-pressure-a-dose-response-randomised-controlled-trial
#12
Chesney K Richter, Ann C Skulas-Ray, Jennifer A Fleming, Christina J Link, Ratna Mukherjea, Elaine S Krul, Penny M Kris-Etherton
Emerging CVD risk factors (e.g. HDL function and central haemodynamics) may account for residual CVD risk experienced by individuals who meet LDL-cholesterol and blood pressure (BP) targets. Recent evidence suggests that these emerging risk factors can be modified by polyphenol-rich interventions such as soya, but additional research is needed. This study was designed to investigate the effects of an isoflavone-containing soya protein isolate (delivering 25 and 50 g/d soya protein) on HDL function (i.e. ex vivo cholesterol efflux), macrovascular function and blood markers of CVD risk...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28660368/high-production-of-genistein-diglucoside-derivative-using-cyclodextrin-glycosyltransferase-from-paenibacillus-macerans
#13
Ruizhi Han, Binbin Ge, Mingyang Jiang, Guochao Xu, Jinjun Dong, Ye Ni
Genistein has been regarded as one important soy isoflavone with multiple health benefits, whereas its applications are limited by the low hydrophilicity. To improve the water solubility, codon optimized cyclodextrin glycosyltransferase from Paenibacillus macerans was employed for genistein transglycosylation in this study. At least four transglycosylation products were produced and identified by HPLC and LC-MS: genistein monoglucoside, diglucoside, triglucoside, and tetraglucoside derivatives. Obviously, the yields of genistein monoglucoside and genistein diglucoside exhibited great superiority compared with other two products...
June 28, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28657651/diet-and-cancer-prevention-dietary-compounds-dietary-micrornas-and-dietary-exosomes
#14
Zarrin Banikazemi, Hemat Aghagolzadeh Haji, Mohsen Mohammadi, Gholamreza Taheripak, Elmira Iranifar, Mohsen Poursadeghiyan, Abdullah Moridikia, Bahman Rashidi, Mohsen Taghizadeh, Hamed Mirzaei
Cancer is one of main health public problems worldwide. Several factors are involved in beginning and development of cancer. Genetic and internal/external environmental factors can be as important agents that effect on emerging and development of several cancers. Diet and nutrition may be as one of important factors in prevention or treatment of various cancers. A large number studies indicated that suitable dietary patterns may help to cancer prevention or could inhibit development of tumor in cancer patients...
June 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28655710/phytoestrogen-isoflavone-intervention-to-engage-the-neuroprotective-effect-of-glutamate-oxaloacetate-transaminase-against-stroke
#15
Savita Khanna, Richard Stewart, Surya Gnyawali, Hallie Harris, Maria Balch, James Spieldenner, Chandan K Sen, Cameron Rink
In the pathophysiologic setting of cerebral ischemia, excitotoxic levels of glutamate contribute to neuronal cell death. Our previous work demonstrated the ability of glutamate oxaloacetate transaminase (GOT) to metabolize neurotoxic glutamate in the stroke-affected brain. Here, we seek to identify small-molecule inducers of GOT expression to mitigate ischemic stroke injury. From a panel of phytoestrogen isoflavones, biochanin A (BCA) was identified as the most potent inducer of GOT gene expression in neural cells...
June 27, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28654894/therapeutic-utility-of-natural-estrogen-receptor-beta-agonists-on-ovarian-cancer
#16
Jinyou Liu, Suryavathi Viswanadhapalli, Lauren Garcia, Mei Zhou, Binoj C Nair, Edward Kost, Rajeshwar Rao Tekmal, Rong Li, Manjeet K Rao, Tyler Curiel, Ratna K Vadlamudi, Gangadhara R Sareddy
Ovarian cancer is the deadliest of all gynecologic cancers. Despite success with initial chemotherapy, the majority of patients relapse with an incurable disease. Development of chemotherapy resistance is a major factor for poor long-term survival in ovarian cancer. The biological effects of estrogens are mediated by estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Emerging evidence suggests that ovarian cancer cells express ERβ that functions as a tumor suppressor; however, the clinical utility of ERβ agonists in ovarian cancer remains elusive...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644496/the-role-of-soybean-extracts-and-isoflavones-in-hormone-dependent-breast-cancer-aromatase-activity-and-biological-effects
#17
Cristina Amaral, Maria Regina T Toloi, Luis Daniel Vasconcelos, Maria José V Fonseca, Georgina Correia-da-Silva, Natércia Teixeira
Estrogen receptor-positive (ER(+)) breast cancer is the most common cause of cancer death in women worldwide. Nowadays, the relationship between soya diet and breast cancer is controversial due to the unknown role of its isoflavones, genistein (G) and daidzein (D). In this work, we investigated not only the anti-tumor properties of a soybean extract (NBSE) but also whether the biotransformation of extract (BSE) by the fungus Aspergillus awamori increased its effectiveness. The BSE showed a stronger anti-aromatase activity and anti-proliferative efficacy in ER(+) aromatase-overexpressing breast cancer cells...
June 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28637300/commercial-rodent-diets-differentially-regulate-autoimmune-glomerulonephritis-epigenetics-and-microbiota-in-mrl-lpr-mice
#18
Michael R Edwards, Rujuan Dai, Bettina Heid, Thomas E Cecere, Deena Khan, Qinghui Mu, Catharine Cowan, Xin M Luo, S Ansar Ahmed
The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local environmental conditions. In this study, we investigated the influence of common rodent diets while keeping other factors constant. Female lupus-prone MRL/lpr mice were subjected to the same housing conditions and given one of the three diets: Teklad 7013 containing isoflavone rich soy and alfalfa, Harlan 2018 isoflavone rich soy-based diet, or ResearchDiets Inc...
June 15, 2017: International Immunology
https://www.readbyqxmd.com/read/28637253/synthesis-and-secretion-of-isoflavones-by-field-grown-soybean
#19
Akifumi Sugiyama, Yumi Yamazaki, Shoichiro Hamamoto, Hisabumi Takase, Kazufumi Yazaki
Isoflavones play important roles in rhizosphere plant-microbe interactions. Daidzein and genistein secreted by soybean roots induce the symbiotic interaction with rhizobia and may modulate rhizosphere interactions with microbes. Yet despite their important roles, little is known about the biosynthesis, secretion and fate of isoflavones in field-grown soybeans. Here, we analysed isoflavone contents and the expression of isoflavone biosynthesis genes in field-grown soybeans. In roots, isoflavone contents and composition did not change with crop growth, but the expressions of UGT4, an isoflavone-specific 7-O-glucosyltransferase, and of ICHG (Isoflavone conjugates hydrolysing beta-glucosidase) was decreased during the reproductive stages...
June 16, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28634083/effects-of-the-soya-isoflavone-genistein-in-early-life-stages-of-the-senegalese-sole-solea-senegalensis-thyroid-estrogenic-and-metabolic-biomarkers
#20
Carmen Sarasquete, Maria Úbeda-Manzanaro, Juan Bosco Ortiz-Delgado
This study examines the effects induced by environmentally relevant concentrations of the isoflavone genistein (3mg/L and 10mg/L) during early life stages of the Senegalese sole. Throughout the hypothalamus-pituitary-thyroid (HPT) axis, several neurohormonal regulatory thyroid signalling patterns (thyroglobulin/Tg, thyroid peroxidase/TPO, transthyretin/TTR, thyroid receptors/TRβ, and iodothrynonine deiodinases, Dio2 and Dio3) were analysed. Furthermore, the expression patterns of estrogen receptor ERβ and haemoprotein Cyp1a were also evaluated...
June 17, 2017: General and Comparative Endocrinology
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