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Isoflavones

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https://www.readbyqxmd.com/read/28436456/synthesis-and-anti-obesity-effects-in-vivo-of-crotadihydrofuran-c-as-a-novel-ppar%C3%AE-antagonist-from-crotalaria-albida
#1
Qin-Hu Sun, Yu Zhang, Gui-Xin Chou
Crotadihydrofuran C (CC) from the herbs of Crotalaria albida is able to inhibit adipocyte differentiation and lipid accumulation. However, the effects of CC on obesity and metabolic disorders have not yet been elucidated. In our study, the first enantioselective synthesis of the 2-isopropenyl dihydrofuran isoflavone skeleton (CC) is described. The convenient and efficient synthetic protocols developed skilfully solve the problems of the ortho-para directing group and Suzuki coupling reaction using a boronic acid pinacol ester that was more stable and easy to obtain...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28434035/does-soy-protein-affect-circulating-levels-of-unbound-igf-1
#2
REVIEW
Mark Messina, Pamela Magee
INTRODUCTION: Despite the enormous amount of research that has been conducted on the role of soyfoods in the prevention and treatment of chronic disease, the mechanisms by which soy exerts its physiological effects are not fully understood. The clinical data show that neither soyfoods nor soy protein nor isoflavones affect circulating levels of reproductive hormones in men or women. However, some research suggests that soy protein, but not isoflavones, affects insulin-like growth factor I (IGF-1)...
April 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28430815/soy-and-fish-as-features-of-the-japanese-diet-and-cardiovascular-disease-risks
#3
Yukio Yamori, Miki Sagara, Yoshimi Arai, Hitomi Kobayashi, Kazumi Kishimoto, Ikuko Matsuno, Hideki Mori, Mari Mori
In the World Health Organization (WHO)-coordinated Cardiovascular Disease and Alimentary Comparison Study, isoflavones (I; biomarker for dietary soy) and taurine (T; biomarker for dietary fish) in 24-hour-urine (24U) were inversely related to coronary heart disease (CHD) mortality. High levels of these biomarkers are found in Japanese people, whose CHD mortality is lowest among developed countries. We analyzed the association of these biomarkers with cardiovascular disease risk in the Japanese to know their health effects within one ethnic population...
2017: PloS One
https://www.readbyqxmd.com/read/28429578/soy-isoflavones-enhance-%C3%AE-defensin-synthesis-and-secretion-in-endometrial-epithelial-cells-with-exposure-to-tlr3-agonist-polyinosinic-polycytidylic-acid
#4
Yotesawee Srisomboon, Sutthasinee Poonyachoti, Chatsri Deachapunya
PROBLEM: β-defensins are important innate chemical barriers that protect the endometrium from pathogen invasion. The effects of soy isoflavones, genistein and daidzein, on the expression and secretion of porcine β-defensins (PBD) in endometrial epithelial cells were investigated under normal or poly I:C-stimulated conditions. METHOD OF STUDY: Primary cultured porcine endometrial epithelial (PE) cells were pretreated with genistein or daidzein followed by poly I:C inoculation...
April 21, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28427531/improvement-of-soybean-products-through-the-response-mechanism-analysis-using-proteomic-technique
#5
Xin Wang, Setsuko Komatsu
Soybean is rich in protein/vegetable oil and contains several phytochemicals such as isoflavones and phenolic compounds. Because of the predominated nutritional values, soybean is considered as traditional health benefit food. Soybean is a widely cultivated crop; however, its growth and yield are markedly affected by adverse environmental conditions. Proteomic techniques make it feasible to map protein profiles both during soybean growth and under unfavorable conditions. The stress-responsive mechanisms during soybean growth have been uncovered with the help of proteomic studies...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28425936/genistein-ameliorates-ischemia-reperfusion-induced-renal-injury-in-a-sirt1-dependent-manner
#6
Wei-Fang Li, Kang Yang, Ping Zhu, Hong-Qian Zhao, Yin-Hong Song, Kuan-Can Liu, Wei-Feng Huang
Renal ischemia/reperfusion (I/R) injury continues to be a complicated situation in clinical practice. Genistein, the main isoflavone found in soy products, is known to possess a wide spectrum of biochemical and pharmacological activities. However, the protective effect of genistein on renal I/R injury has not been well investigated. In the current study, we explore whether genistein exhibits its renal-protective effects through SIRT1 (Sirtuin 1) in I/R-induced mice model. We found the treatment of genistein significantly reduced renal I/R-induced cell death, simultaneously stimulating renal cell proliferation...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28423925/antioxidant-and-alpha-glucosidase-inhibitory-activities-of-isoflavonoids-from-the-rhizomes-of-ficus-tikoua-bur
#7
Guangmiao Fu, Wenjuan Li, Xiangzhong Huang, Runzhi Zhang, Kai Tian, Shuqun Hou, Yukui Li
A new unique isoflavone derivatives with a cyclic-monoterpene-substituent, ficusin C (1), together with five known compounds (2-6), were isolated from the rhizomes of Ficus tikoua. Their structures were elucidated on the basis of spectroscopic data interpretation, mass spectrometric analysis and comparison with literature data of related compounds. Antioxidant and α-glucosidase inhibitory activities of these compounds were evaluated by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay and α-glucosidase inhibitory experiment, respectively...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28421123/study-of-the-hypoglycemic-activity-of-derivatives-of-isoflavones-from-cicer-arietinum-l
#8
Ying Wei, Pengshou Li, Bo Li, Jiaqi Gao, Dongchao Wang, Lingling Qin, Wen Sun, Yunling Xu, Haoxia Shi, Tunhai Xu, Tonghua Liu
The chickpea, a food and medicine used by the people of Xinjiang, has a beneficial hypoglycemic effect. To better utilize this national resource and develop hypoglycemic agents from components of the chickpea, a series of new derivatives of isoflavone compounds from the chickpea were synthesized. An insulin-resistant (IR) HepG2 cell model was used to screen the hypoglycemic activities of these compounds. And the structure-activity relationships of these compounds were explored. Additionally, several combinations of these compound displayed higher hypoglycemic activity than any single compound, and they had similar hypoglycemic activity to that of the positive control group (p > 0...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28415978/bacterial-communities-and-metabolic-activity-of-faecal-cultures-from-equol-producer-and-non-producer-menopausal-women-under-treatment-with-soy-isoflavones
#9
Lucía Guadamuro, Anja B Dohrmann, Christoph C Tebbe, Baltasar Mayo, Susana Delgado
BACKGROUND: Isoflavones are polyphenols with estrogenic activity found mainly in soy and soy-derived products that need to be metabolised in the intestine by the gut bacteria to be fully active. There is little knowledge about isoflavone bioconversion and equol production in the human intestine. In this work, we developed an in vitro anaerobic culture model based on faecal slurries to assess the impact of isoflavone supplementation on the overall intestinal bacterial composition changes and associated metabolic transformations...
April 17, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28409880/osajin-inhibits-solar-uv-induced-cyclooxygenase-2-expression-through-direct-inhibition-of-rsk2
#10
Jong-Eun Kim, Yong-Seok Heo, Ki Won Lee
Solar ultraviolet light (sUV) has been shown to promote the development of skin disorders including inflammation, photoaging, and skin carcinogenesis. Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera, commonly referred to as the Osage orange. In this study, we observed that osajin inhibited sUV-induced cyclooxygenase (COX)-2 protein expression in both HaCaT and JB6 cells. COX-2 is a major mediator of skin inflammation. sUV activated the transcription factors nuclear factor- κB and activator protein-1 which, in turn, induces COX-2 expression...
April 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28391863/evaluation-of-new-natural-deep-eutectic-solvents-for-the-extraction-of-isoflavones-from-soy-products
#11
Sylwia Bajkacz, Jakub Adamek
Natural deep eutectic solvents (NADESs) are considered to be new, safe solvents in green chemistry that can be widely used in many chemical processes such as extraction or synthesis. In this study, a simple extraction method based on NADES was used for the isolation of isoflavones (daidzin, genistin, genistein, daidzein) from soy products. Seventeen different NADES systems each including two or three components were tested. Multivariate data analysis revealed that NADES based on a 30% solution of choline chloride: citric acid (molar ratio of 1:1) are the most effective systems for the extraction of isoflavones from soy products...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28391283/mothers-consumption-of-soy-drink-but-not-black-tea-increases-the-flavonoid-content-of-term-breast-milk-a-pilot-randomized-controlled-intervention-study
#12
Frank Jochum, Birgit Alteheld, Pamela Meinardus, Norbert Dahlinger, Antonia Nomayo, Peter Stehle
OBJECTIVE: We performed a pilot RCT to prove the hypothesis that a controlled ingestion of polyphenol-rich beverages (soy drink, decaffeinated black tea) in nutritive dosages by nursing women has an effect on the composition (flavonoid concentration, total antioxidant capacity) of breast milk. METHODS: Healthy nursing women were supplemented with either 250 mL of a soy drink (12 mg isoflavones; n = 18), 300 mL decaffeinated black tea (67 mg catechins; n = 18), or 300 mL water (n = 8, control) for 6 days...
April 8, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28388729/letter-to-the-editor-response-to-the-effects-of-soy-isoflavones-on-metabolic-status-of-patients
#13
Alan Gaby
No abstract text is available yet for this article.
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28381809/coumestrol-down-regulates-melanin-production-in-melan-a-murine-melanocytes-through-degradation-of-tyrosinase
#14
Jeong Ah Hwang, Nok Hyun Park, Yong Joo Na, Hae Kwang Lee, John Hwan Lee, Yong Jin Kim, Chang Seok Lee
Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28373425/me-143-is-superior-to-genistein-in-suppression-of-wnt-signaling-in-colon-cancer-cells
#15
COMPARATIVE STUDY
Sofya Pintova, Kestutis Planutis, Marina Planutiene, Randall F Holcombe
BACKGROUND: This study tested the effect of the soy isoflavones genistein and ME-143, and two chemotherapeutic agents, 5-fluorouracil (5FU) and oxaliplatin, on WNT signaling. MATERIALS AND METHODS: Colon cancer cell lines RKO (hereditary nonpolyposis colorectal cancer type) and DLD1 (most common colorectal cancer type driven by a mutation in WNT pathway) were utilized. WNT throughput was measured using a β-catenin-responsive SuperTopFlash luciferase assay. A stabilized β-catenin construct was employed to test β-catenin involvement in the mechanism of drug activity...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28372246/one-step-salting-out-assisted-liquid-liquid-extraction-followed-by-uhplc-esi-ms-ms-for-the-analysis-of-isoflavones-in-soy-milk
#16
Hee Jeong Park, Mun Yhung Jung
We developed and validated a fast UHPLC-ESI-MS/MS in combination with one step salting-out assisted liquid-liquid extraction (SALLE) for high throughput analysis of 12 isoflavones in soy milks. Conventional sample preparation requires two steps composing time-consuming freeze-drying (72h) and solvent extraction (2h). The SALLE required only about 40min, which was over 100times faster without compromising the extraction efficiency. The baseline separation of 12 isoflavones was achieved in 2.5min by the UHPLC-MS/MS which is the fastest chromatographic method ever reported...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28372188/evaluation-of-the-isoflavone-and-total-phenolic-contents-of-kefir-fermented-soymilk-storage-and-after-the-in-vitro-digestive-system-simulation
#17
Meg da Silva Fernandes, Fernando Sanches Lima, Daniele Rodrigues, Cintia Handa, Marcela Guelfi, Sandra Garcia, Elza Iouko Ida
This study aimed to evaluate the isoflavone and total phenolic contents in kefir-fermented soymilk storage and after the in vitro digestive system simulation (DSS). Soymilk was fermented with kefir culture (0.02UC/L) at 25°C for 15h and stored at 4°C for 4days. After the fermentation and storage, the isoflavone and total phenolic contents were quantified by high performance liquid chromatography and spectrophotometry, respectively. The cell viability of lactic acid bacteria and yeast was evaluated. Fermentation promoted an increase of approximately 3log CFU/g cycles of the microorganisms and the storage process did not alter the aglycone isoflavones and total phenolic contents...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28367764/formononetin-an-isoflavone-activates-amp-activated-protein-kinase-%C3%AE-catenin-signalling-to-inhibit-adipogenesis-and-rescues-c57bl-6-mice-from-high-fat-diet-induced-obesity-and-bone-loss
#18
Jyoti Gautam, Vikram Khedgikar, Priyanka Kushwaha, Dharmendra Choudhary, Geet Kumar Nagar, Kapil Dev, Preety Dixit, Divya Singh, Rakesh Maurya, Ritu Trivedi
Balance between adipocyte and osteoblast differentiation is the key link of disease progression in obesity and osteoporosis. We have previously reported that formononetin (FNT), an isoflavone extracted from Butea monosperma, stimulates osteoblast formation and protects against postmenopausal bone loss. The inverse relationship between osteoblasts and adipocytes prompted us to analyse the effect of FNT on adipogenesis and in vivo bone loss, triggered by high-fat diet (HFD)-induced obesity. The anti-obesity effect and mechanism of action of FNT was determined in 3T3-L1 cells and HFD-induced obese male mice...
March 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28367262/an-open-label-evaluator-blinded-study-of-the-efficacy-and-safety-of-a-new-nutritional-supplement-in-androgenetic-alopecia-a-pilot-study
#19
Anna J Nichols, Olivia Bosshardt Hughes, Agnese Canazza, Martin N Zaiac
Objective: To evaluate the effectiveness of a novel oral supplement, Forti5(®), containing green tea extract, omega 3 and 6 fatty acids, cholecalciferol, melatonin, beta-sitosterol, and soy isoflavones, and in the management of subjects with androgenetic alopecia. Design: A prospective case series of 10 subjects. Setting: Open-label, evaluator-blinded, proof-of-concept study. Participants: Ten adult subjects with androgenetic alopecia completed the study. Subjects were not allowed to use oral or topical hair growth products in the 24 weeks preceding the study or during the study...
February 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28364866/being-overweight-or-obese-is-associated-with-harboring-a-gut-microbial-community-not-capable-of-metabolizing-the-soy-isoflavone-daidzein-to-o-desmethylangolensin-in-peri-and-post-menopausal-women
#20
Lindsey M Miller, Johanna W Lampe, Katherine M Newton, Gabrielle Gundersen, Sharon Fuller, Susan D Reed, Cara L Frankenfeld
OBJECTIVE: Obesity can be a considerable health concern for peri- and post-menopausal women. Evidence suggests an association between the gut microbiome and obesity. The study objective was to evaluate the association between being overweight or obese and phenotypic markers of having an overall gut microbial environment not capable of metabolizing the isoflavone daidzein to equol or O-desmethylangolensin (ODMA). STUDY DESIGN: Cross-sectional study of 137 peri- and 218 post-menopausal women, aged 44-55 years, who consumed at least three servings per week of soy (source of daidzein)...
May 2017: Maturitas
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