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https://www.readbyqxmd.com/read/28938591/genistein-up-regulates-mir-20a-to-disrupt-spermatogenesis-via-targeting-limk1
#1
Hao Gu, Wei Wu, Beilei Yuan, Qiuqin Tang, Dan Guo, Yiqiu Chen, Yankai Xia, Lingqing Hu, Daozhen Chen, Jiahao Sha, Xinru Wang
Genistein (GEN) is one of the isoflavones that has effect on male reproduction. However, the underlying mechanism remains unknown. miRNAs are a type of small non-coding RNAs that play important roles in spermatogenesis. We measured the GEN levels and miR-17-92 cluster expression in infertile subjects and found that miR-17-92 might be involved in GEN induced abnormal spermatogenesis. To clarify, we fed adult ICR mice with different doses of GEN (0, 0.5, 5, 50 and 250 mg/kg/day) for 35 days to study the underlying mechanism...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937793/investigating-the-antiangiogenic-anti-drug-resistance-and-apoptotic-effects-of-soy-isoflavone-extract-alone-or-in-combination-with-docetaxel-on-murine-4t1-breast-tumor-model
#2
Ehsan Hejazi, Maryam Tavakoli, Mahmood Jeddi-Tehrani, Masoud Kimiagar, Jalal Hejazi, Mohammad Houshyari, Zohre Amiri, Hale Edalatkhah, Javad Nasrollahzadeh, Farah Idali
BACKGROUND: One major concern in the treatment of cancer patients during chemotherapy is drug resistance. Here we investigated the effects of soy isoflavone extracts alone or in combination with Docetaxel on the drug resistance, angiogenesis, apoptosis, and tumor volume in mouse 4T1 breast tumor model. METHODS: Sixty female BALB/c mice were randomly divided into 4 groups: control, dietary soy isoflavone extract [Iso, 100 mg/kg diet (0.01%)], Docetaxel (10 mg/kg) injection, and the combination of dietary soy isoflavone extract and intravenous Docetaxel injection (Docetaxel + Iso)...
September 22, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28932421/structure-of-7-hy-droxy-3-2-meth-oxy-phen-yl-2-tri-fluoro-meth-yl-4h-chromen-4-one
#3
John Nicolson Low, Ligia R Gomes, Alexandra Gaspar, Fernanda Borges
Herein, the synthesis and crystal structure of 7-hy-droxy-3-(2-meth-oxy-phen-yl)-2-tri-fluoro-meth-yl-4H-chromen-4-one, C17H11F3O4, are reported. This isoflavone is used as a starting material in the preparation an array of potent and competitive FPR antagonists. The pyran ring significantly deviates from planarity and the dihedral angle between the benzo-pyran mean plane and that of the exocyclic benzene ring is 88.18 (4)°. In the crystal, O-H⋯O hydrogen bonds connect the mol-ecules into C(8) chains propagating in the [010] direction...
July 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28930233/dietary-isoflavones-and-breast-cancer-risk
#4
REVIEW
Samira Ziaei, Reginald Halaby
Breast cancer is the deadliest neoplasm in women globally, resulting in a significant health burden. In many cases, breast cancer becomes resistant to chemotherapy, radiation, and hormonal therapies. It is believed that genetics is not the major cause of breast cancer. Other contributing risk factors include age at first childbirth, age at menarche, age at menopause, use of oral contraceptives, race and ethnicity, and diet. Diet has been shown to influence breast cancer incidence, recurrence, and prognosis...
April 7, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930193/different-effects-of-maternal-low-isoflavone-soy-protein-and-genistein-consumption-on-hepatic-lipid-metabolism-of-21-day-old-male-rat-offspring
#5
Anna Han, Sae Bom Won, Young Hye Kwon
Amino acid composition and isoflavone are alleged contributors to the beneficial effects of soy protein isolate (SPI) on lipid metabolism. Therefore, we investigated the contributing component(s) of SPI in a maternal diet to the regulation of lipid metabolism in offspring. We also determined serum parameters in dams to investigate specific maternal cues that might be responsible for this regulation. Female rats were fed either a casein (CAS), a low-isoflavone SPI, or a casein plus genistein (GEN, 250 mg/kg) diet for two weeks before mating, as well as during pregnancy and lactation...
September 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28929692/-metabolomics-of-bovine-serum-albumin-induced-allergic-reactions-based-on-uplc-q-tof-ms
#6
Yuan-Yuan Gu, Dan-Dan Zhang, Cheng Feng, Yu Wang, Da-Zhong Chen, Yan-Hong Wang
The metabonomic techniques were used to study the changes in endogenous metabolites between urines of rats in normal physiological conditions and bovine serum albumin induced allergic reactions, identify potential biomarkers associated with allergic reactions, and then analyze the metabolic pathways and the metabolic mechanisms of allergic reactions. The bovine serum albumin-induced allergic reactions in rats were adopted as a model to detect histamine and tryptase in rat serum and observe the issue morphology of lungs and trachea in rats...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928506/perennial-legumes-as-a-source-of-ingredients-for-healthy-food-proximate-mineral-and-phytoestrogen-composition-and-antibacterial-activity
#7
Bronislava Butkutė, Audrius Padarauskas, Jurgita Cesevičienė, Alvydas Pavilonis, Lukas Taujenis, Nijolė Lemežienė
ABSTRACT: Perennial legumes have been used as edible or medicinal plants since ancient times. The focus of the current study are perennial legumes-Trifolium pratense L., T. medium L., Medicago sativa L., M. lupulina L., Onobrychis viciifolia Scop., Astragalus glycyphyllos L. and A. cicer L.-of branching stage as a potential source of value-added ingredients for healthy food. Freeze-dried samples were analysed for proximal composition, mineral, isoflavone and coumestrol contents as well as for antimicrobial activity...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28926527/genistein-suppresses-aerobic-glycolysis-and-induces-hepatocellular-carcinoma-cell-death
#8
Sainan Li, Jingjing Li, Weiqi Dai, Qinghui Zhang, Jiao Feng, Liwei Wu, Tong Liu, Qiang Yu, Shizan Xu, Wenwen Wang, Xiya Lu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Xiaoming Fan, Wenhui Mo, Ling Xu, Chuanyong Guo
BACKGROUND: Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1α) levels and glycolysis in tumour cells are associated with an increased risk of mortality, cancer progression, and resistance to therapy. However, the effect of genistein on HIF-1α and glycolysis in hepatocellular carcinoma (HCC) is still unclear. METHODS: Cell viability, apoptosis rate, lactate production, and glucose uptake were measured in HCC cell lines with genistein incubation...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28916571/effect-of-soy-and-soy-isoflavones-on-obesity-related-anthropometric-measures-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#9
REVIEW
Masoumeh Akhlaghi, Morteza Zare, Fatemeh Nouripour
Soy may be a suitable food for anti-obesity efforts because of its high protein and isoflavone content. We conducted this meta-analysis to evaluate potential effects of soy and soy isoflavones on weight, waist circumference, and fat mass. PubMed, MEDLINE, Scopus, EMBASE, and Cochrane databases were searched. Twenty-four trials with soy and 17 trials with isoflavones passed the eligibility stage. According to the results, soy showed no overall statistically significant effect on weight, waist circumference, or fat mass, but a significant increasing effect on weight was observed in some circumstances: for instance, in obese subjects [mean difference (MD): 0...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28915128/polyphenols-dietary-assessment-and-role-in-the-prevention-of-cancers
#10
Joseph A Rothwell, Viktoria Knaze, Raul Zamora-Ros
PURPOSE OF REVIEW: Polyphenols are a large and diverse family of phytochemicals widely consumed by humans. Here we summarize the latest epidemiological evidence for associations between cancer risk and polyphenol intake, taking into account difficulties in the accurate estimation of exposure. RECENT FINDINGS: Flavonoids are the most studied subgroup of polyphenols with regard to cancer risk. In recent epidemiological studies, total flavonoid intake has rarely been associated with a reduction in cancer risk...
September 14, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28911675/phenolic-constituents-of-pulicaria-undulata-l-c-a-mey-sub-sp-undulata-asteraceae-antioxidant-protective-effects-and-chemosystematic-significances
#11
Sameh R Hussein, Mona M Marzouk, Maha M Soltan, Emad K Ahmed, Mahmoud M Said, Ahmed R Hamed
One new naturally isoflavone compound, 5,7,2',3',4' penta hydroxyl isoflavone-4'-O-β-glucopyranoside (1) was isolated from the aqueous methanol extract (AME) of Pulicaria undulata subsp. undulata, together with seven known compounds: kaempferol (2), kaempferol 3-O-β-glucoside (3), quercetin (4), quercetin 3-O-β-glucoside (5), quercetin 3-O-β-galactoside (6), quercetin 3,7-di OCH3 (7), and caffeic acid (8). Their structures were established through chemical (acid hydrolysis) and spectral analysis (UV, NMR, and ESIM)...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911617/hydrolysis-of-isoflavone-in-black-soy-milk-using-cellulose-bead-as-enzyme-immobilizer
#12
Kuan-I Chen, Yijun Yao, Hong-Jhang Chen, Yi-Chen Lo, Roch-Chui Yu, Kuan-Chen Cheng
The establishment of a catalytic system to enrich isoflavone aglycones in black soybean milk was investigated in this study. Beta-glucosidase, which was covalently immobilized onto cellulose beads, exhibited a significant efficiency for the conversion of 4-nitrophenyl β-d-glucuronide to p-nitrophenol over the sol-gel method. The Michaelis constant (Km) of the cellulose bead enzymatic system was determined to be 1.50±0.10 mM. Operational reusability of the cellulose bead enzymatic system was justified for more than 10 batch reactions in black soy milk...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911547/multifunctions-of-dietary-polyphenols-in-the-regulation-of-intestinal-inflammation
#13
REVIEW
Makoto Shimizu
Food for specified health use is a type of functional food approved by the Japanese government, with more than 1250 products in 10 health-claim categories being approved as of April 2016. Polyphenols are currently used as functional ingredients in seven of the 10 categories. Although they have not yet been used for the food-for-specified-health-use category of "gut health promotion," polyphenols are expected to contribute to the future development of gut-modulating food. Intestinal functions include digestion/absorption, acting as a barrier, recognition of external factors, and signal transduction...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911541/food-macromolecule-based-nanodelivery-systems-for-enhancing-the-bioavailability-of-polyphenols
#14
REVIEW
Bing Hu, Xixia Liu, Chunlan Zhang, Xiaoxiong Zeng
Diet polyphenols-primarily categorized into flavonoids (e.g., flavonols, flavones, flavan-3-ols, anthocyanidins, flavanones, and isoflavones) and nonflavonoids (with major subclasses of stilbenes and phenolic acids)-are reported to have health-promoting effects, such as antioxidant, antiinflammatory, anticarcinoma, antimicrobial, antiviral, and cardioprotective properties. However, their applications in functional foods or medicine are limited because of their inefficient systemic delivery and poor oral bioavailability...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911538/corrigendum-to-hydrolysis-of-isoflavone-in-black-soy-milk-using-cellulose-bead-as-enzyme-immobilizer-j-food-drug-anal-24-2016-788-795
#15
Kuan-I Chen, Yijun Yao, Hong-Jhang Chen, Yi-Chen Lo, Roch-Chui Yu, Kuan-Chen Cheng
No abstract text is available yet for this article.
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910863/acceleration-of-aglycone-isoflavones-and-%C3%AE-aminobutyric-acid-production-from-doenjang-using-whole-cell-biocatalysis-accompanied-by-protease-treatment
#16
Yincong Li, Seockmo Ku, Myeong Soo Park, Zhipeng Li, Geun Eog Ji
Recently, soy bean isoflavone aglycones (i.e. daidzein and genistein) and γ-aminobutyric acid (GABA) have begun to receive considerable consumer attention due to their potential as nutraceuticals. To produce these ingredients, multiple microorganisms and their enzymes are commonly used for catalysis in the nutraceutical industry. In this work, we introduce a novel fermentation process that uses whole cell biocatalysis to accelerate γ-aminobutyric acid and isoflavone aglycones production in doenjang (traditional Korean soybean paste)...
September 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28910527/comparative-structural-characterization-of-spiral-dextrin-inclusion-complexes-with-vitamin-e-or-soy-isoflavone
#17
Ping-Ping Wang, Xin-Sheng Qin, Qing-Yu Yang, Zhigang Luo, Zhi-Gang Xiao, Xichun Peng
In this study, the preparation and structural properties of spiral dextrin (SD)/vitamin E and SD/soy isoflavone inclusion complexes were studied. SD was obtained from debranched normal maize starch using isoamylases. After fractionation using a novel method of gradient ethanol precipitation, SD was separated into different fractions, among which SD-40 was found to be the optimal host molecule to prepare spiral dextrin inclusion complexes with vitamin E or soy isoflavone. The XRD and 13C CP/MAS NMR suggested that the crystalline structures of SD-40/vitamin E and SD-40/soy isoflavone were V6II and V6III types, respectively...
September 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28886438/daidzein-down-regulates-ubiquitin-specific-protease-19-expression-through-estrogen-receptor-%C3%AE-and-increases-skeletal-muscle-mass-in-young-female-mice
#18
Masahiro Ogawa, Takehiro Kitano, Natsuha Kawata, Takashi Sugihira, Tomoya Kitakaze, Naoki Harada, Ryoichi Yamaji
Ubiquitin-specific protease 19 (USP19) is a key player in the negative regulation of muscle mass during muscle atrophy. Loss-of-function approaches demonstrate that 17β-estradiol (E2) increases USP19 expression through estrogen receptor (ER) α and consequently decreases soleus muscle mass in young female mice under physiological conditions. Daidzein is one of the main isoflavones in soy, and activates ERβ-dependent transcription. Here, we investigated the effects of daidzein on E2-increased USP19 expression and E2-decreased soleus muscle mass in young female mice...
August 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28885710/isoflavones-from-green-vegetable-soya-beans-and-their-antimicrobial-and-antioxidant-activities
#19
Taoyun Wang, Yanli Liu, Xiaoran Li, Qiongming Xu, Yulin Feng, Shilin Yang
BACKGROUND: Green vegetable soya beans, known as Maodou in China, supplied as vegetable-type fruits of soybean plant. Previous study indicated Green vegetable soya beans exhibited anti-oxidative and anti-inflammatory activities. However, the material basis and pharmacological activities of green soybean plant were not unraveled clearly. In this study, we investigated the chemical ingredients and their pharmacological activities. RESULTS: The chemical ingredients investigation indicated that two new isoflavones, 2'-hydroxyerythrin A (1), and daidzein-7-O-β-D-{6''-[(E)-but-2-enoyl]}glycoside (2), together with seven known ones, 7,4'-dihydroxy-6-methoxyisoflavone (3), daidzein (4), daidzin (5), genistein (6), formononetin (7), ononin (8), and isoerythrinin A (9) were obtained...
September 8, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28881500/the-different-resistance-of-two-astragalus-plants-to-uv-b-stress-is-tightly-associated-with-the-organ-specific-isoflavone-metabolism
#20
Yang Liu, Jia Liu, Yu Wang, Ann Abozeid, Dong-Mei Tian, Xiao-Ning Zhang, Zhong-Hua Tang
In this work, the changes in isoflavone levels and the expression of genes involved in their biosynthesis were studied in two Astragalus by UPLC-MS and real-time PCR after 10 days of UV-B treatment (λmax = 313 nm, 804 J/ m(2) ). Isoflavones were significantly induced by UV-B irradiation. The influence might be activated by the regulation of these target genes. Our results indicate that (1) the resistance of A. membranaceus might not be as good as A. mongholicus in the enhanced UV-B radiation environment; (2) the enhanced accumulation of Calycosin and Calycosin-7-glucoside with UV-B treatment in roots of A...
September 7, 2017: Photochemistry and Photobiology
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