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Isoflavones

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https://www.readbyqxmd.com/read/28324208/the-%C3%AE-subunit-of-%C3%AE-conglycinin-and-various-glycinin-subunits-of-soy-are-not-required-to-modulate-hepatic-lipid-metabolism-in-rats
#1
Cynthia Chatterjee, Jiajie Liu, Carla Wood, Christine Gagnon, Elroy R Cober, Judith A Frégeau-Reid, Stephen Gleddie, Chao-Wu Xiao
PURPOSE: This study examined the effect of soy proteins with depletion of different subunits of the two major storage proteins, β-conglycinin and glycinin, on hepatic lipids and proteins involved in lipid metabolism in rats, since the bioactive component of soy responsible for lipid-lowering is unclear. METHODS: Weanling Sprague Dawley rats were fed diets containing either 20% casein protein in the absence (casein) or presence (casein + ISF) of isoflavones or 20% alcohol-washed soy protein isolate (SPI) or 20% soy protein concentrates derived from a conventional (Haro) or 2 soybean lines lacking the α' subunit of β-conglycinin and the A1-3 (1TF) or A1-5 (1a) subunits of glycinin...
March 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28319828/genistein-affects-proliferation-and-migration-of-bovine-oviductal-epithelial-cells
#2
Daniela C García, Pablo A Valdecantos, Dora C Miceli, Mariela Roldán-Olarte
Genistein is one of the most abundant isoflavones in soybean. This molecule induces cell cycle arrest and apoptosis in different normal and cancer cells. Genistein has been of considerable interest due to its adverse effects on bovine reproduction, altering estrous cycle, implantation and fetal development and producing subfertility or infertility. The objective of this work was to study the effects of genistein on the expression of selected genes involved in the regulation of cell cycle and apoptosis. Primary cultures of bovine oviductal epithelial cells (BOEC) were treated with different genistein concentrations (0...
March 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28318254/phosphate-fertilizer-and-growing-environment-changes-the-phytochemicals-oil-quality-and-nutritional-composition-of-roundup-ready-gm-and-conventional-soybean
#3
Tatiane Scilewski da Costa Zanatta, Roberta Manica-Berto, Cristiano Dietrich Ferreira, Michele Maciel Crizel Cardozo, Cesar Valmor Rombaldi, Rui Carlos Zambiazi, Álvaro Renato Guerra Dias
The phosphorus intake (P), genotype, and growth environment in soybean cultivation can affect the composition of the bean. This experiment was conducted in two locations (microregion I and microregion II) by using a randomized complete block design, including conventional soybean cultivars (BRS Sambaíba), genetically modified cultivars (Msoy 9144 Roundup Ready-RR), and varying doses of phosphorus fertilizer (0, 60, 120, and 240 kg/ ha P2O5). Soybeans were evaluated for chemical composition, total phenols, phytic acid, individual isoflavones, antioxidant activity, oil quality, fatty acid profile, total carotenoids, and individual tocopherols...
March 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28317483/a-critical-review-of-bioactive-food-components-and-of-their-functional-mechanisms-biological-effects-and-health-outcomes
#4
Rosa Pérez-Gregorio, Jesús Simal-Gándara
BACKGROUND: Eating behaviours are closely related to some medical conditions potentially leading to death such as cancer, cardiovascular disease and diabetes. Healthy eating practices, maintaining a normal weight, and regular physical activity could prevent up to 80% of coronary heart disease, 90% of type-2 diabetes and one-third of all cancers[1]. METHOD: Over the last two decades, the food industry has invested much effort in research and development of healthier, more nutritious foods...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28303029/tmf-and-glycitin-act-synergistically-on-keratinocytes-and-fibroblasts-to-promote-wound-healing-and-anti-scarring-activity
#5
Ga Young Seo, Yoongho Lim, Dongsoo Koh, Jung Sik Huh, Changlim Hyun, Young Mee Kim, Moonjae Cho
Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4',6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo...
March 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28298268/effects-of-dietary-flavonoids-on-reverse-cholesterol-transport-hdl-metabolism-and-hdl-function
#6
REVIEW
Courtney L Millar, Quinn Duclos, Christopher N Blesso
Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their well-documented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function...
March 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28297748/bioconversion-using-lactic-acid-bacteria-ginsenosides-gaba-and-phenolic-compounds
#7
REVIEW
Na-Kyoung Lee, Hyun-Dong Paik
Lactic acid bacteria (LAB) are used as fermentation starters in vegetable and dairy products and influence the pH and flavors of foods. For many centuries, LAB have been used to manufacture fermented foods; therefore, they are generally regarded as safe. LAB produce various substances such as lactic acid, β-glucosidase, or β-galactosidase, making them useful as fermentation starters. Existing functional substances have been tried as fermentation substrates for better bioavailability or other functions. Representative materials that were bioconverted using LAB have been reported and include minor ginsenoside, γ-amino butyric acid, equol, aglycone, bioactive isoflavones, genistein, daidzein, and others...
March 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28293641/functional-effects-of-prebiotic-fructans-in-colon-cancer-and-calcium-metabolism-in-animal-models
#8
Marisol Rivera-Huerta, Vania Lorena Lizárraga-Grimes, Ibrahim Guillermo Castro-Torres, Mabel Tinoco-Méndez, Lucía Macías-Rosales, Francisco Sánchez-Bartéz, Graciela Guadalupe Tapia-Pérez, Laura Romero-Romero, María Isabel Gracia-Mora
Inulin-type fructans are polymers of fructose molecules and are known for their capacity to enhance absorption of calcium and magnesium, to modulate gut microbiota and energy metabolism, and to improve glycemia. We evaluated and compared the effects of Chicory inulin "Synergy 1®" and inulin from Mexican agave "Metlin®" in two experimental models of colon cancer and bone calcium metabolism in mice and rats. Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28289606/simple-efficient-and-economical-methods-for-isolation-and-estimation-of-novel-isoflavone-using-rp-hplc
#9
Afroze Alam, Kamlesh Kumar Naik, Navneet Kumar Upadhaya, Shailendra Kumar, K L Dhar
The study was undertaken to develop a simplified procedure for the isolation of bioactive isoflavone from Iris kashmiriana, using a direct method of isolation, avoiding the use of chromatographic techniques. The compound was isolated by commercially viable procedure. The extraction of powdered drug (500 g) was done with petroleum ether (60-80) using a Soxhlet apparatus (24 h run). The petroleum ether extract (gums and resins 2.13 g) was obtained and the marc (400 g) was subjected to extraction with 95% methanol using a Soxhlet apparatus (24 h run)...
2017: MethodsX
https://www.readbyqxmd.com/read/28283000/characterization-and-evaluation-of-a-self-microemulsifying-drug-delivery-system-containing-tectorigenin-an-isoflavone-with-low-aqueous-solubility-and-poor-permeability
#10
Yunrong Zhang, Li He, Shanlan Yue, Qingting Huang, Yuhong Zhang, Junyi Yang
The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility. The microemulsion formed by TG-SMEDDS was globular, edge smooth, clear-cut, and distribution homogeneous under transmission electron microscope. The stability studies revealed that TG-SMEDDS remained stable at room temperature for at least 3 months...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28276200/vasomotor-symptoms-due-to-natural-menopause-systematic-review-and-network-meta-analysis-nma-of-treatment-effects-from-the-nice-menopause-guideline
#11
Grammati Sarri, Hugo Pedder, Sofia Dias, Yelan Guo, Mary Ann Lumsden
BACKGROUND: Vasomotor symptoms (VMS) are the hallmarks of menopause, occurring in approximately 75% of postmenopausal women in the UK and are severe in 25%. OBJECTIVES: To identify which treatments are most clinically effective for the relief of VMS for non-hysterectomized women in natural menopause. SEARCH STRATEGY: English publications in MEDLINE, Embase and The Cochrane Library up to 13(th) January 2015 were searched. SELECTION CRITERIA: Randomized trials (RCTs) of treatments for women with a uterus for the outcomes of frequency of VMS (up to 26 weeks), vaginal bleeding and discontinuation...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28274719/kinetic-features-of-carbonyl-reductase-1-acting-on-glutathionylated-aldehydes
#12
Roberta Moschini, Rossella Rotondo, Giovanni Renzone, Francesco Balestri, Mario Cappiello, Andrea Scaloni, Umberto Mura, Antonella Del-Corso
The attempt to evaluate the human carbonyl reductase 1 (CBR1) activity on 3-glutathionylated-4-hydroxyalkanals through the classical spectrophotometric assay, in which NADPH oxidation is monitored at 340 nm, failed. This was due to the ability of the enzyme to catalyze the reduction of the free aldehyde form and at the same time the oxidation of the hemiacetal structure of this class of substrates, thus leading to the occurrence of a disproportion reaction sustained by a redox recycle of the pyridine cofactor...
March 6, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28273931/dietary-flavonoids-cyp1a1-genetic-variants-and-the-risk-of-colorectal-cancer-in-a-korean-population
#13
Young Ae Cho, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether CYP1A1 genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28272319/facilitated-visual-interpretation-of-scores-in-principal-component-analysis-by-bioactivity-labeling-of-1h-nmr-spectra-metabolomics-investigation-and-identification-of-a-new-%C3%AE-glucosidase-inhibitor-in-radix-astragali
#14
Yueqiu Liu, Nils T Nyberg, Anna K Jäger, Dan Staerk
Radix Astragali is a component of several traditional medicines used for the treatment of type 2 diabetes in China. Radix Astragali is known to contain isoflavones, which inhibit α-glucosidase in the small intestines, and thus lowers the blood glucose levels. In this study, 21 samples obtained from different regions of China were extracted with ethyl acetate, then the IC50-values were determined, and the crude extracts were analyzed by 1H-NMR spectroscopy. A principal component analysis of the 1H-NMR spectra labeled with their IC50-values, that is, bioactivity-labeled 1H-NMR spectra, showed a clear correlation between spectral profiles and the α-glucosidase inhibitory activity...
March 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28264475/association-between-dietary-share-of-ultra-processed-foods-and-urinary-concentrations-of-phytoestrogens-in-the-us
#15
Eurídice Martínez Steele, Carlos A Monteiro
The aim of this study was to examine the relationship between dietary contribution of ultra-processed foods and urinary phytoestrogen concentrations in the US. Participants from cross-sectional 2009-2010 National Health and Nutrition Examination Survey aged 6+ years, selected to measure urinary phytoestrogens and with one 24-h dietary recall were evaluated (2692 participants). Food items were classified according to NOVA (a name, not an acronym), a four-group food classification based on the extent and purpose of industrial food processing...
February 28, 2017: Nutrients
https://www.readbyqxmd.com/read/28264445/equol-a-dietary-daidzein-gut-metabolite-attenuates-microglial-activation-and-potentiates-neuroprotection-in-vitro
#16
Lalita Subedi, Eunhee Ji, Dongyun Shin, Jongsik Jin, Joo Hong Yeo, Sun Yeou Kim
Estrogen deficiency has been well characterized in inflammatory disorders including neuroinflammation. Daidzein, a dietary alternative phytoestrogen found in soy (Glycine max) as primary isoflavones, possess anti-inflammatory activity, but the effect of its active metabolite Equol (7-hydroxy-3-(4'-hydroxyphenyl)-chroman) has not been well established. In this study, we investigated the anti-neuroinflammatory and neuroprotective effect of Equol in vitro. To evaluate the potential effects of Equol, three major types of central nervous system (CNS) cells, including microglia (BV-2), astrocytes (C6), and neurons (N2a), were used...
February 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28264435/proteins-in-soy-might-have-a-higher-role-in-cancer-prevention-than-previously-expected-soybean-protein-fractions-are-more-effective-mmp-9-inhibitors-than-non-protein-fractions-even-in-cooked-seeds
#17
Ana Lima, Jennifer Oliveira, Filipe Saúde, Joana Mota, Ricardo Boavida Ferreira
The search for anticancer MMP-9 inhibitors (MMPIs) in food products has become a major goal for research. MMPIs in soy have been related only to saponins and isoflavones, but recently, low specific protein fractions in soybeans were shown to reduce MMP-9 activity as well. The present work aimed at comparing the MMPI potential of protein fractions (P) and non-protein fractions (NP) isolated from soybean seeds, before and after soaking and cooking, mimicking dietary exposures. Reverse and substrate zymography, as well as a fluoregenic DQ gelatin assay were used to evaluate MMP-9 activities...
February 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28263368/dietary-isoflavone-intake-and-all-cause-mortality-in-breast-cancer-survivors-the-breast-cancer-family-registry
#18
Fang Fang Zhang, Danielle E Haslam, Mary Beth Terry, Julia A Knight, Irene L Andrulis, Mary B Daly, Saundra S Buys, Esther M John
BACKGROUND: Soy foods possess both antiestrogenic and estrogen-like properties. It remains controversial whether women diagnosed with breast cancer should be advised to eat more or less soy foods, especially for those who receive hormone therapies as part of cancer treatment. METHODS: The association of dietary intake of isoflavone, the major phytoestrogen in soy, with all-cause mortality was examined in 6235 women with breast cancer enrolled in the Breast Cancer Family Registry...
March 6, 2017: Cancer
https://www.readbyqxmd.com/read/28263364/soy-foods-isoflavones-and-breast-cancer
#19
EDITORIAL
Omer Kucuk
No abstract text is available yet for this article.
March 6, 2017: Cancer
https://www.readbyqxmd.com/read/28260893/enhancing-the-oral-bioavailability-of-biochanin-a-by-encapsulation-in-mixed-micelles-containing-pluronic-f127-and-plasdone-s630
#20
Xiaoyan Wu, Weihong Ge, Tengfei Shao, Weijun Wu, Jian Hou, Li Cui, Jing Wang, Zhenghai Zhang
Biochanin A (BCA), a natural dietary isoflavone, has been reported to show anticancer activities. However, its low biological availability and poor aqueous solubility limit its usefulness as a chemotherapeutic agent. We developed BCA-loaded micelles with Pluronic F127 and Plasdone S630 (BCA-FS). The optimized, spherical-shaped BCA-FS was obtained at a ratio of 1:1 (F127:S630). The particle size was 25.17±1.2 nm, and the zeta potential was -10.9±0.24 mV. BCA solubility in water increased to 5.0 mg/mL after encapsulation, and the drug-loading efficiency was 5...
2017: International Journal of Nanomedicine
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