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https://www.readbyqxmd.com/read/28537893/alpha-mangostin-induces-apoptosis-through-activation-of-reactive-oxygen-species-and-ask1-p38-signaling-pathway-in-cervical-cancer-cells
#1
Chien-Hsing Lee, Tsung-Ho Ying, Hui-Ling Chiou, Shu-Ching Hsieh, Shiua-Hua Wen, Ruey-Hwang Chou, Yi-Hsien Hsieh
Alpha-mangostin, a natural xanthonoid, has been reported to possess the anti-cancer property in various types of human cancer. However, its effects and mechanism of α-mangostin in cervical cancer remain unclear. We found that α-mangostin effectively inhibited cell viability, resulted in loss of mitochondrial membrane potential (MMP), release of cytochrome C, increase of Bax, decrease of Bcl-2, and activation of caspase-9/caspase-3 cascade in cervical cancer cells. Alpha-mangostin elevated the contents of reactive oxygen species (ROS) to activate p38...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535132/granulomatous-inflammatory-response-to-a-microchip-implanted-in-a-dog-for-eight-years
#2
Claire Legallet, Kelley Thieman Mankin, Kathy Spaulding, Joanne Mansell
An 8 yr old neutered male springer spaniel dog was referred to Texas A&M University, College of Veterinary Medicine for a large, firm, fixed mass, located in the dorsal cervical tissue. The dog was otherwise healthy and had undergone microchip implantation approximately 8 yr prior. Radiographs, ultrasound, and microchip scanner confirmed the presence of a microchip within the mass. The microchip and associated mass were surgically excised, and histopathologic examination revealed granulomatous inflammation surrounding a cracked microchip...
May 23, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28532919/image-guided-lateral-mass-osteotomy-for-en-bloc-resection-of-cervical-ewing-s-sarcoma-a-technical-note
#3
Julian Li, Kevin Phan, Tommy Manh Tran, Ralph Mobbs, Ralph Stanford
BACKGROUND: En bloc resection of Ewing's sarcoma according to Enneking's principles is technically challenging in the cervical spine due to the proximity of important neurovascular structures, complex local anatomy and biomechanical instability of radical resection. The rarity of Ewing's sarcoma and variability of presentation justifies ongoing compilation of the surgical nuances and subtleties of en bloc resection in the cervical spine. CASE DESCRIPTION: We present a 34-year-old male with Ewing's sarcoma of the neck who underwent successful en bloc resection using a novel technique of splitting the laminae and osteomising the lateral masses using image guidance...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28531940/contusional-cerebellar-hemorrhage-related-to-placement-in-the-protrusion-position-after-atlantoaxial-fusion
#4
Yoshinari Miyaoka, Mikinobu Takeuchi, Norimitsu Wakao, Masahiro Aoyama, Kazuhiro Hongo, Masakazu Takayasu
BACKGROUND: Various complications after C1 lateral mass and C2 pedicle screw fusion surgery (C1LM-C2PSFS) have been reported. However, to our knowledge, this is the first report of contusional cerebellar hemorrhage caused by placement in the protrusion (chin-out) position after C1LM-2PSFS. CASE DESCRIPTION: An 81-year-old woman complaining of gait disturbance and clumsiness of both hands was diagnosed with cervical myelopathy with atlantoaxial subluxation. After we performed C1LM-C2PSFS, her neurologic deficits gradually improved, and there was no radiologic evidence of construct failure...
May 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28530261/a-rare-case-of-embryonal-rhabdomyosarcoma-of-the-parapharyngeal-space
#5
G Iannella, M De Vincentiis, A Corsi, A Greco, G Magliulo
A 24-year-old man was admitted to our Otolaryngology Department following a head and neck CT scan performed for cranial trauma that showed a bulky neoformation in the right parapharyngeal space. Magnetic resonance imaging confirmed the presence of an oval formation with sharp margins and colliquative areas of necrosis involving the right parapharyngeal space. The mass was completely excised by a latero-cervical approach. Based on histological features and immunohistochemical analysis, a diagnosis of embryonal rhabdomyosarcoma of the parapharyngeal space was made...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28525474/anatomy-of-lamina-in-the-subaxial-cervical-spine-with-the-special-reference-to-translaminar-screws-ct-and-cadaveric-analysis-with-screw-trajectory-simulation
#6
Woojin Cho, Jason T Le, Adam L Shimer, Brian C Werner, John A Glaser, Francis H Shen
STUDY DESIGN: A cadaveric study. SUMMARY OF BACKGROUND DATA: Translaminar screws were initially developed for C2 fixation. Since then, their usage has expanded to include the subaxial cervical spine, and thoracic and lumbar spine. To the best of our knowledge, special anatomy for inserting translaminar screws in the subaxial cervical spine has not been studied. OBJECTIVE: To report the special anatomy for inserting translaminar screws in the subaxial cervical spine...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28524752/widening-of-the-safe-trajectory-range-during-subaxial-cervical-pedicle-screw-placement-advantages-of-a-curved-pedicle-probe-and-laterally-located-starting-point-without-creating-a-funnel-shaped-hole
#7
Subum Lee, Junghan Seo, Moon Kyu Lee, Sang Ryong Jeon, Sung Woo Roh, Seung Chul Rhim, Jin Hoon Park
OBJECTIVE The small diameter of cervical pedicles and a large transverse cervical pedicle angle are challenges that have led spinal surgeons to investigate how they could achieve a wider safety trajectory and reduce the insertion angle during cervical pedicle screw (CPS) placement. In this paper, the authors detail the advantages of using a curved pedicle probe and a laterally located entry point for overcoming these challenges. METHODS From March 2012 to May 2016, the authors performed posterior cervical fusions using CPSs on 119 consecutive patients...
May 19, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28522371/c1-lateral-mass-screw-insertion-from-the-caudal-dorsal-to-the-cranial-ventral-direction-as-an-alternate-method-for-c1-fixation-a-quantitative-anatomical-and-morphometric-evaluation
#8
Mehmet Senoglu, Ali Karadag, Burak Kinali, Baran Bozkurt, Cigdem Icke, Duygu Halacoglu Savran, Erik H Middlebrooks
OBJECT: C1 lateral mass screw has been widely used for fixation of the upper cervical spine. However, traditional fixation methods are not without complication. Morphometric measurement of an alternative approach is conducted. METHODS: Three-dimensional CT scans of the cervical spine obtained in 100 adults were evaluated, and key measurements were determined for screw entry points, trajectories, and screw lengths for placement of a C1 screw via this alternate approach...
May 15, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28520565/use-of-a-tilting-orthopedic-fracture-table-to-facilitate-proper-patient-positioning-during-intrathecal-neurolysis-with-hyperbaric-phenol-a-case-report
#9
Nathaniel H Loo, Gerald Matchett
We describe the case of a 41-year-old woman with metastatic cervical cancer and a large mass eroding into the pelvis and left lumbosacral plexus. The patient had intractable left lower extremity pain refractory to standard therapies, and she elected to undergo intrathecal neurolysis. A diagnostic intrathecal block was performed at the T11-12 interspace followed by intrathecal neurolysis with 6% phenol in glycerin on a subsequent date. During both procedures, we used a tilting radiolucent orthopedic fracture table to maintain strict left lateral-supine positioning...
May 17, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28508693/a-metabolite-profiling-method-for-diagnosis-of-precancerous-cervical-lesions-and-hpv-persistence
#10
Heather Walker, Michael Burrell, Janet Flatley, Hilary Powers
AIM: With the advent of rapid metabolic profiling techniques and of portable mass spectrometers we examined whether cells distinguished by their cytology and persistence of human papillomavirus infection, could be easily differentiated by their metabolite profile. MATERIALS & METHODS: Direct injection electrospray mass spectrometry was used in a nontargeted double-blind experiment. Samples were collected from women diagnosed with one of two grades of cervical cytology and exhibiting either human papilloma virus persistence or clearance...
May 16, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28508348/cost-analysis-of-minimally-invasive-radical-hysterectomy-for-cervical-cancer-performed-by-a-single-surgeon-in-an-italian-center-an-update-in-gynecologic-oncological-field
#11
Antonio Pellegrino, Gianluca Raffaello Damiani, Giorgio Fachechi, Cecilia Pirovano, Maria Gaetani, Aly Youssef
The objective of this study is to perform an economic analysis and examine the influence of procedural volume of our hospital, evaluating the accounting systems of Robotic radical hysterectomy (RRH) vs Laparoscopic radical hysterectomy (TLRH) in patients with cervical carcinoma, due to the costs widely variable and lack in literature. Costs were collected prospectively, from March 2010 to March 2016. Direct costs were determined by examining the overall medical pathway for each type of intervention. 52 patients with cervical carcinoma, which were matched by age, body mass index, tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, comorbidity, previous neoadjuvant chemotherapy, histology type, and tumor grade to obtain homogeneous samples...
May 15, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28508239/double-crush-syndrome-caused-by-cervical-spondylosis-and-vertebral-artery-loop
#12
Young Joon Rho, Woo Jin Choe
PURPOSE: The purpose of this article is to report a successful treatment experience in a rare case of simultaneous cervical nerve root compression by spondylotic cervical foraminal stenosis and a vertebral artery loop. METHODS: 51-year-old man presented with a 4-year history of left-sided cervical pain radiating to the left shoulder with progressive exacerbation of weakness on left shoulder girdle muscles for 7 months. The patient had no history of trauma. The patient's CT and MRI revealed impingement of the left C6 cervical nerve root by a tortuous vertebral artery loop and also by narrowed left C5-6 cervical foramen that had undergone spondylotic changes...
May 15, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28507974/a-rare-presentation-of-cervical-spine-osteochondroma
#13
Vijay Shankar, Kumar Amerendra Singh, Simanchal P Mohanty
INTRODUCTION: Cervical spine osteochondromas are rare tumors that usually involve the posterior spinal elements. Osteochondromas of the cervical spine presenting anteriorly as a mass over the supraclavicular region has not been reported in the literature. CASE REPORT: A 12-year-old boy presented with right sided supraclavicular swelling. Plain radiographs revealed a bony mass. Computerized tomography (CT) and magnetic resonance imaging scans of the cervical region showed a bony mass arising from pedicle and encroaching onto lamina of C6 vertebra...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28502967/neck-and-occipital-pain-caused-by-deep-cervical-intramuscular-lipoma-a-surgical-case
#14
Kazunari Kogure, Michio Yamazaki, Tomonori Tamaki, Yoji Node, Akio Morita
A lipoma is a slow-growing, benign tumor and is usually asymptomatic; hence, surgical intervention can often be avoided in patients with these tumors in the cervical and cranial area. Lipomas arise most commonly in the subcutaneous fat, but occasionally in muscle tissue. Intramuscular lipomas in the cervico-cranial area have rarely been reported. We describe here a patient with a large intramuscular lipoma in the deep cervical tissue. The patient experienced troublesome pain in the neck and occipital area, and surgical treatment was therefore suggested...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28498291/multi-level-3d-printing-implant-for-reconstructing-cervical-spine-with-metastatic-papillary-thyroid-carcinoma
#15
Xiucan Li, Yiguo Wang, Yongfei Zhao, Jianheng Liu, Songhua Xiao, Keya Mao
STUDY DESIGN: A unique case report. OBJECTIVE: A three-dimensional (3D) printing technology is proposed for reconstructing multi-level cervical spine (C2-C4) after resection of metastatic papillary thyroid carcinoma in a middle-age female patient. SUMMARY OF BACKGROUND DATA: Papillary thyroid carcinoma is a malignant neoplasm with a relatively favorable prognosis. A metastatic lesion in multi-level cervical spine (C2-C4) destroys neurological functions and causes local instability...
May 11, 2017: Spine
https://www.readbyqxmd.com/read/28498250/prediction-of-site-specific-tumor-relapses-in-patients-with-stage-i-ii-endometrioid-endometrial-cancer
#16
Taru Tuomi, Annukka Pasanen, Arto Leminen, Ralf Bützow, Mikko Loukovaara
OBJECTIVE: The aim of this study was to investigate the association of predictors of an advanced disease and/or poor outcome with the occurrence of tumor relapses in different anatomical sites in patients with stage I-II endometrioid endometrial cancer. METHODS: A total of 929 patients were included in the study. The median follow-up time was 57 months (range, 1-108 months). The studied variables were: poor tumor differentiation, myometrial invasion 50% or greater, tumor size 3 cm or greater, lymphovascular space invasion, cervical stromal invasion, positive peritoneal cytology, old age (>77 years), obesity (body mass index ≥30 kg/m), and diabetes...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498238/nomogram-predicting-overall-survival-in-operable-cervical-cancer-patients
#17
Ru-Ru Zheng, Xiao-Wan Huang, Wen-Yue Liu, Rong-Rong Lin, Fei-Yun Zheng, Feng Lin
OBJECTIVE: Nomograms are widely used as predictive tools to predict oncological outcomes intuitively and precisely. The aim of our study was to develop a nomogram for predicting overall survival (OS) of patients with early stage cervical cancer. METHODS: In this retrospective study, the clinical, pathological, and hematological data and prognosis of 795 cervical cancer patients were investigated. We identified and incorporated independent significant prognostic factors for OS to develop a nomogram...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28498072/paravertebral-foramen-screw-fixation-for-posterior-cervical-spine-fusion-biomechanical-study-and-description-of-a-novel-technique
#18
Satoshi Maki, Masaaki Aramomi, Yusuke Matsuura, Takeo Furuya, Mitsutoshi Ota, Yasushi Iijima, Junya Saito, Takane Suzuki, Chikato Mannoji, Kazuhisa Takahashi, Masashi Yamazaki, Masao Koda
OBJECTIVE Fusion surgery with instrumentation is a widely accepted treatment for cervical spine pathologies. The authors propose a novel technique for subaxial cervical fusion surgery using paravertebral foramen screws (PVFS). The authors consider that PVFS have equal or greater biomechanical strength than lateral mass screws (LMS). The authors' goals of this study were to conduct a biomechanical study of PVFS, to investigate the suitability of PVFS as salvage fixation for failed LMS, and to describe this novel technique...
May 12, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28496090/-mediastinal-thyroid-carcinoma-report-of-a-case
#19
Yusuke Kita, Ryo Kobayashi, Hiroshi Nogimura, Kumiko Hongo, Hideyo Miyato, Yukio Ishihara, Naoki Takabayashi, Takeyuki Hiramatsu
71-year-old woman was pointed out to have an asymptomatic mediastinal tumor. Chest computed tomography(CT) showed a well-demarcated mass measuring 7 cm in diameter in the anterior mediastinum. We resected the mass through a median sternotomy. The tumor had a clear margin without invasion to the surrounding tissue and did not show continuity with the cervical thyroid gland. Histopathologically, the tumor was diagnosed as follicular thyroid carcinoma with capsular invasion. This is an exceptionally rare case.
May 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28491486/crest-calcinosis-affecting-the-lumbar-and-cervical-spine-and-the-use-of-minimally-invasive-surgery
#20
Kassem Faraj, Kristin Perez-Cruet, Mick Perez-Cruet
Calcinosis in CREST (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) syndrome can affect the spinal and paraspinal areas. We present the first case to our knowledge where a CREST syndrome patient required surgery for spinal calcinosis in both the cervical and lumbar areas. A 66-year-old female with a history of CREST syndrome presented with right-sided lower extremity radicular pain. A computed tomography (CT) scan showed bilateral lumbar masses (5.8 cm on the right, 3...
April 8, 2017: Curēus
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