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https://www.readbyqxmd.com/read/29682479/submandibular-lipoblastoma-case-report-of-a-rare-tumor-in-childhood
#1
Olfa El Amine, Meyssa Belghith, Hasna Salhi, Aida Goucha, Amor Gamoudi
Lipoblastoma is a rare, benign tumor usually occurring in childhood. It is essentially localized in the extremities and trunk, with few cases reported in the neck. We report the case of a 2-year-old girl with a rapidly enlarging, painless neck mass. Magnetic resonance imaging (MRI) revealed a 3-cm mass in the right submandibular region. Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed. Complete surgical excision via a lateral cervical approach demonstrated a white soft tissue with an adherent ganglion...
April 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29682136/metastatic-cervical-paravertebral-solitary-fibrous-tumor-detected-by-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#2
Hoiwan Cheung, Courtney Lawhn-Heath, Giselle Lopez, Maya Vella, Carina Mari Aparici
Solitary fibrous tumor/hemangiopericytomas (SFT/HPC) are soft tissue tumors that can arising from the abomen, pleura, head and neck, or extremities. We report an unusual case of recurrent hemangiopericytoma in a 67-year-old female presenting with a painless and palpable mass within her right posterior neck. Eight years after initial resection of the mass, a follow-up MRI showed multiple enlarging calvarial lesions. A whole body FDG-PET/CT revealed not only hypermetabolic calvarial lesions but also numerous hypermetabolic axillary node and osseous metastases...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29681412/volatolome-of-the-female-genitourinary-area-toward-the-metabolome-of-cervical-cancer
#3
Miriam Rodríguez-Esquivel, Juan Rosales, Rafael Castro, Teresa Apresa-García, Ónix Garay, Pablo Romero-Morelos, Daniel Marrero-Rodríguez, Keiko Taniguchi-Ponciano, Ricardo López-Romero, Héctor Guerrero-Flores, Betsabé Morales, Mónica Mendoza-Rodríguez, Dejanira Mosso-Lara, Itzalia Núñez-Nolasco, Paola Castro-Alba, Sergio E Meza-Toledo, Mauricio Salcedo
BACKGROUND AND AIMS: Different Volatile Organic Compounds (VOCs) obtained from several human fluids (volatolome) has been reported as potential biomarkers for a great variety of diseases including cancer. At present, volatolomic profile data of the female genital area is scarce. METHODS: To identify the VOCs related to the female genitourinary area of healthy and Cervical Cancer (CC)-affected women used a pad, as a non-invasive tool for sample gathering was necessary...
April 19, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29679590/phase-i-ii-pharmacokinetic-and-pharmacodynamic-evaluation-of-two-levonorgestrel-only-contraceptive-patches-in-a-multicenter-randomized-trial
#4
Carolyn L Westhoff, Beatrice A Chen, Jeffrey T Jensen, Kurt Barnhart, Michael Thomas, Stephanie Teal, Diana Blithe
OBJECTIVES: To evaluate the pharmacokinetic and pharmacodynamic effects of two novel levonorgestrel (LNG)-only contraceptive patches. STUDY DESIGN: This multi-center Phase I/II trial randomized participants to use a 7-day transdermal patch designed to deliver a 40 mcg or 75 mcg daily LNG dose for 11 consecutive weeks; randomization was stratified by body mass index (BMI) <32 or 32-40kg/m2 . Evaluations occurred twice weekly for 5weeks, then once weekly with supplemental visits for participants reporting a urinary LH surge...
April 18, 2018: Contraception
https://www.readbyqxmd.com/read/29679454/primary-lymphoepthelial-carcinoma-of-the-parotid-gland-pictorial-review-of-a-rare-entity
#5
Arani Halder, Jennifer Sommerville, Mitesh Gandhi
Lymphoepithelial carcinoma (LEC) is a rare malignancy of the salivary gland arising from the parotid in 80% of cases. LEC is indistinguishable histologically from more common non-keratinising undifferentiated nasopharyngeal carcinoma (NPC). Up to 40% of patients with primary LEC present with a cervical metastasis and histological assessment of the primary lesion or nodal metastasis may be reported as NPC. The absence of a nasopharyngeal lesion on imaging and endoscopic assessment together with a parotid mass strengthens the case for a LEC...
April 20, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29672633/design-synthesis-dft-docking-studies-and-adme-prediction-of-some-new-coumarinyl-linked-pyrazolylthiazoles-potential-standalone-or-adjuvant-antimicrobial-agents
#6
Sunil Kumar, Vikram Saini, Indresh K Maurya, Jayant Sindhu, Mukesh Kumari, Ramesh Kataria, Vinod Kumar
The control of antimicrobial resistance (AMR) seems to have come to a dead end. The major consequences of the use and abuse of antibacterial drugs are the development of resistant strains due to genetic mutability of both pathogenic and nonpathogenic microorganisms. We, herein, report the synthesis, characterization and biological activities of coumarin-thiazole-pyrazole (CTP) molecular hybrids with an effort to explore and overcome the increasing antimicrobial resistance. The compounds were characterized by analyzing their IR, Mass, 1H and13C NMR spectral data and elemental analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29670527/comparative-metabolomics-analysis-of-cervicitis-in-human-patients-and-a-phenol-mucilage-induced-rat-model-using-liquid-chromatography-tandem-mass-spectrometry
#7
Xiaoyong Zhang, Junmao Li, Bin Xie, Bei Wu, Shuangxia Lei, Yun Yao, Mingzhen He, Hui Ouyang, Yulin Feng, Wen Xu, Shilin Yang
Cervicitis is an exceedingly common gynecological disorder that puts women at high risk of sexually transmitted infections and induces a series of reproductive system diseases. This condition also has a significant impact on quality of life and is commonly misdiagnosed in clinical practice due to its complicated pathogenesis. In the present study, we performed non-targeted plasma metabolomics analysis of cervicitis in both plasma samples obtained from human patients and plasma samples from a phenol mucilage induced rat model of cervicitis, using ultra-performance liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29669770/accidental-and-potentially-life-threatening-finding-pulsatile-mass-of-the-hypopharynx
#8
Joana Maria Soares Ferreira, Edite Coimbra, António Faria Almeida, Artur Condé
Anatomical variations of the cervical part of the internal carotid artery (ICA) are not rare in the general population. They are usually asymptomatic and more common in the elderly. We report the case of a 70-year-old Caucasian woman who was referred to our department due to chronic cough. We performed a flexible nasofibrolaryngoscopy that demonstrated the presence of a pulsatile mass in the hypopharynx. After performing a cervical contrast-enhanced CT, the mass turned out to be an aberrant variation of the cervical part of the ICA...
April 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29668367/which-patients-with-cervical-squamous-cell-carcinoma-might-benefit-from-neoadjuvant-chemotherapy
#9
Omar Mahmoud, Mark H Einstein
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
April 18, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29667008/eco-friendly-synthesis-in-vitro-anti-proliferative-evaluation-and-3d-qsar-analysis-of-a-novel-series-of-monocationic-2-aryl-heteroaryl-substituted-6-2-imidazolinyl-benzothiazole-mesylates
#10
Livio Racané, Lucija Ptiček, Mirela Sedić, Petra Grbčić, Sandra Kraljević Pavelić, Branimir Bertoša, Irena Sović, Grace Karminski-Zamola
Herein, we describe the synthesis of twenty-one novel water-soluble monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates 3a-3u and present the results of their anti-proliferative assays. Efficient syntheses were achieved by three complementary simple two-step synthetic protocols based on the condensation reaction of aryl/heteroaryl carbaldehydes or carboxylic acid. We developed an eco-friendly synthetic protocol using glycerol as green solvent, particularly appropriate for the condensation of thermally and acid-sensitive heterocycles such as furan, benzofuran, pyrrole, and indole...
April 17, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/29664450/quantitative-assessment-of-vertebral-artery-anatomy-in-relation-to-cervical-pedicles-surgical-considerations-based-on-regional-differences
#11
Amro Al-Habib, Fahad Albadr, Jehad Ahmed, Abdulrahman Aleissa, Abdullah Al Towim
OBJECTIVE: To quantify the anatomic relationship between the Cervical pedicle screw (CPS), vertebral artery (VA), and related anatomic structures in the Saudi population. METHODS: This retrospective single center study included 50 consecutive patients (35 males) with normal neck findings on computed tomography angiography performed for trauma or vascular evaluation between 2012 and 2014. Radiologic parameters were assessed and correlated with age, weight, height, and body mass index (BMI)...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29663038/-relevance-of-spinal-navigation-in-reconstructive-surgery-of-the-cervical-spine
#12
REVIEW
R Kothe, M Richter
BACKGROUND: Spinal navigation has made significant advances in the last two decades. After initial experiences with pedicle screws in the thoracic and lumbar spine, technological improvements have resulted in their increased application in the cervical spine. Instrumentation techniques like cervical pedicle screws, lateral mass screws in C1 and transarticular screws C1/C2 have become standard due to the application of image guidance. TECHNIQUE: Different navigation techniques can be distinguished based on the type of imaging...
April 16, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29662675/anterior-versus-posterior-approach-to-treat-cervical-spondylotic-myelopathy-clinical-and-radiological-results-with-long-period-of-follow-up
#13
Ziad A Audat, Mohammad D Fawareh, Ahmad M Radydeh, Moutasem M Obeidat, Mohannad A Odat, Khaldoon M Bashaireh, Mohammad M Barbarawi, Murad T Nusairat, Amna B Ibraheem, Mohammad Z Audat
Background: Cervical spondylotic myelopathy increases with age, but not all cases are symptomatic. It is usually diagnosed clinically and radiologically (X-ray and magnetic resonance imaging). Surgical treatment is indicated in severe symptomatic cases, while treatment controversy exists in the presence of less severe cases. Anterior and posterior approaches are generally used for decompression with no significant differences in the results of both. Methods: A total of 287 patients of cervical spondylotic myelopathy were treated at our hospital between January 2004 and December 2015...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29661053/differential-diagnosis-of-sinonasal-lymphoma-and-squamous-cell-carcinoma-on-ct-mri-and-pet-ct
#14
Seok-Hyun Kim, Sue-Jean Mun, Hak-Jin Kim, Seon Lin Kim, Sung-Dong Kim, Kyu-Sup Cho
Objective The purpose of this study was to analyze computed tomography (CT) and magnetic resonance (MR) images and to evaluate the maximum standardized uptake value (SUV max) of positron emission tomography (PET)/CT parameters between sinonasal non-Hodgkin's lymphoma (NHL) and squamous cell carcinoma (SCC), knowing the imaging features that distinguish sinonasal NHL from SCC. Study Design Case series with chart review. Setting University tertiary care facility. Subjects and Methods We analyzed the features on CT, MR imaging, and PET/CT of 78 patients diagnosed with sinonasal NHL or SCC histopathologically...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29660055/accuracy-assessment-of-pedicle-and-lateral-mass-screw-insertion-assisted-by-customized-3d-printed-drill-guides-a-human-cadaver-study
#15
Peter A J Pijpker, Joep Kraeima, Max J H Witjes, D L Marinus Oterdoom, Maarten H Coppes, Rob J M Groen, Jos M A Kuijlen
BACKGROUND: Accurate cervical screw insertion is of paramount importance considering the risk of damage to adjacent vital structures. Recent research in 3-dimensional (3D) technology describes the advantage of patient-specific drill guides for accurate screw positioning, but consensus about the optimal guide design and the accuracy is lacking. OBJECTIVE: To find the optimal design and to evaluate the accuracy of individualized 3D-printed drill guides for lateral mass and pedicle screw placement in the cervical and upper thoracic spine...
April 5, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29652189/a-review-and-update-on-papillary-immature-metaplasia-of-the-uterine-cervix-a-distinct-subset-of-low-grade-squamous-intraepithelial-lesion-proposing-a-possible-cell-of-origin
#16
Soon Auck Hong, Su Hyun Yoo, Jene Choi, Stanley J Robboy, Kyu-Rae Kim
CONTEXT: - Papillary immature metaplasia (PIM) is a known papillary cervical lesion associated with low-risk human papilloma virus (LR-HPV). OBJECTIVE: - To evaluate additional clinicopathologic features and the HPV genotypes of PIM and discuss the presumptive cell of origin. DESIGN: - A total of 26 PIM cases were evaluated by p16INK4a , cytokeratin (CK) 7, and CK17 immunohistochemical stainings. Human papilloma virus genotyping was performed, by using HPV DNA Chip, HPV polymerase chain reaction (PCR), and real-time PCR...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29650822/-a-case-of-poorly-differentiated-carcinoma-of-unknown-primary-site-with-risk-of-choriocarcinoma-syndrome-effectively-treated-with-reduced-bleomycin-cisplatin-etoposide-combination-regimen-bep-regimen
#17
Motohiko Okano, Hiroyasu Oda, Mikiya Ishihara, Satoshi Tamaru, Kanako Saito, Yoshiki Yamashita, Toshiro Mizuno, Naoyuki Katayama
A 64-year-old man visited his physician complaining of bilateral gynecomastia and left shoulder pain. Chest X-ray showed multiple bilateral masses in the lung, and he was referred to our hospital. Radiographical findings, elevation of serum total hCG, and histological findings of the cervical lymph node revealed multiple pulmonary, nodal, and brain metastases of poorly differentiated carcinoma of an unknown primary site with choriocarcinoma components. He was administered a regimen of reduced bleomycin, cisplatin, etoposide combination(reduced BEP regimen)to reduce the risk of acute respiratory failure with intra-alveolar hemorrhage related to post-chemotherapy early tumor necrosis...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29628805/accuracy-of-motion-palpation-flexion-extension-test-in-identifying-the-seventh-cervical-spinal-process
#18
Luciana C Póvoa, Ana P A Ferreira, José F C Zanier, Julio G Silva
Objective: The aim of this study was to evaluate the accuracy of a motion palpation procedure, the flexion-extension test, in localizing the spinous process of the seventh cervical vertebra (C7). Methods: We analyzed 101 adult participants with metal markers that permitted the identification of the C7 spinous process. This analysis occurred during a flexion-extension test and was confirmed by radiography. Data sample characteristics were analyzed by descriptive statistics, and the relationship between independent variables (weight, height, sex, age, and body mass index [BMI]) and dependent variables (coincidence between the most prominent vertebra and the stationary vertebra, as determined by the flexion-extension test) was determined via logistic regression...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29627641/occiput-axis-crossing-translaminar-screw-fixation-technique-using-offset-connectors-an-in-vitro-biomechanical-study
#19
Jiyong Gu, Weiwei Lei, Zong Xin, Yi Wu, Lin Peng, Zhibin Li, Zize Feng, Minchan Zhao, Songtao Qi, Yuntao Lu
OBJECTIVE: Fixation with the axis vertebra (C2) using pedicle screws is commonly used to treat an unstable occipitocervical junction; however, it is accompanied by a risk of vertebral artery injury. The occiput-C2 (OC2) crossing translaminar screw fixation technique may avoid this risk, but rod implantation is difficult. Offset connectors can help facilitate this construct. This study aimed to evaluate the stability of a technique for OC2 crossing translaminar screw fixation using offset connectors (C2LAM + OF) in comparison with other methods...
April 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29626984/the-proteome-of-fetal-fluids-in-mares-with-experimentally-induced-placentitis
#20
S C Loux, B A Ball
INTRODUCTION: Placental inflammation (placentitis) is one of the leading causes of late-term abortion in mares. Although prognosis is good assuming early diagnosis and treatment, diagnostics are limited. METHODS: To better characterize the disease and identify potential biomarkers, we analyzed the proteome of fetal fluids (amniotic and allantoic) in both control mares (n = 5) and mares with experimentally-induced placentitis (n = 5) using LTQ-Orbitrap mass-spectrometry...
April 2018: Placenta
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