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https://www.readbyqxmd.com/read/28449510/chondromatous-hamartoma-of-cervical-esophagus-a-case-report-and-literature-review
#1
Chong Zhang, Jinming Xu, Zhitian Wang, Zhehao He, Hanjin Yang, Jian Hu
Esophageal chondromatous hamartomas are very rare tumors, characterized by proliferating hyaline cartilage cells. We described the case of a 64-year-old woman, with a progressive foreign body sensation in the laryngopharynx caused by an intraluminal pedicled mass. Transcervical esophagectomy was performed and intraoperative biopsy revealed the mass was a cervical esophageal chondromatous hamartoma. The patient's postoperative course was uneventful and she recovered well. A review of the literature was conducted, and the symptoms, locations, histopathology findings, treatment methods and follow up results of esophageal hamartoma cases were summarized...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448533/determining-the-optimal-number-and-location-of-cutoff-points-with-application-to-data-of-cervical-cancer
#2
Chung Chang, Meng-Ke Hsieh, Wen-Yi Chang, An Jen Chiang, Jiabin Chen
It is often helpful to classify biomarker values into groups of different risk levels to facilitate evaluation of a biological, physiological, or pathological state. Stratification of patients into two risk groups is commonly seen, but there is always need for more than two groups for fine assessment. So far, there are no standard methods or tools to help decide how many cutoff points are optimal. In this study, we developed a comprehensive package that included methods to determine both the optimal number and locations of cutoff points for both survival data and dichotomized outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28445472/unsuspected-osteochondroma-like-outgrowths-in-the-cranial-base-of-hereditary-multiple-exostoses-patients-and-modeling-and-treatment-with-a-bmp-antagonist-in-mice
#3
Sayantani Sinha, Christina Mundy, Till Bechtold, Federica Sgariglia, Mazen M Ibrahim, Paul C Billings, Kristen Carroll, Eiki Koyama, Kevin B Jones, Maurizio Pacifici
Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2. HME is characterized by formation of cartilaginous outgrowths-called osteochondromas- next to the growth plates of many axial and appendicular skeletal elements. Surprisingly, it is not known whether such tumors also form in endochondral elements of the craniofacial skeleton. Here, we carried out a retrospective analysis of cervical spine MRI and CT scans from 50 consecutive HME patients that included cranial skeletal images...
April 26, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28444664/endocrine-complications-of-surgical-treatment-of-thyroid-cancer-an-update
#4
Pedro Iglesias, Juan José Díez
Postoperative hypoparathyroidism (HypoPT) and hypothyroidism (HypoT) are the main endocrine complications after the surgical treatment for thyroid cancer. Postsurgical HypoPT can be transient, protracted or permanent. Its frequency varies according to the underlying cervical pathology, surgical technique, and mainly the experience of the surgeon. Risk factors for HypoPT include aggressiveness of the tumor, extent of surgery, the presence of parathyroid gland in the pathologic specimen, and surgeon experience...
April 25, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28436636/-iodine-131-joint-radio-frequency-ablation-treatment-for-child-with-hyperthyroidism-goiter-one-case-report
#5
Yonghua Chen, Li Liang, Yanlan Fang, Chunlin Wang, Linfa Li, Tian'an Jiang
A 12-year-old girl presented with a history of cervical mass, and one week of throat discomfort and dyspnea. Five years ago, the patient was diagnosed as Hashimoto's thyroiditis and hyperthyroidism; she received antithyroid drug treatment, but the result was not satisfactory. B-ultrasonic showed that the size of thyroid gland was 8.1 cm×3.2 cm in the left and 8.2 cm×4.8 cm in the right. After iodine 131 combined with radiofrequency ablation (RFA) treatment, throat discomfort and recumbent breathing difficulties disappeared, and B-ultrasonic showed that the size of thyroid reduced to 2...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28429638/an-unusual-presentation-of-a-cervical-paraspinal-leiomyoma-in-an-adolescent-female
#6
Jeffrey A Swarz, Arayamparambil C Anilkumar, Douglas C Miller, N Scott Litofsky, Tomoko Tanaka
Objective We describe an apparently unique case of an extra-uterine leiomyoma in the cervical paraspinus including its evaluation and management. Methods A 14-year-old girl was referred to the neurology clinic for an abnormal head CT following a concussion. MRI revealed a homogenously enhancing left cervical paraspinal mass. The patient underwent complete resection and subsequent genetic testing and counseling were obtained to determine the presence of Li-Fraumeni Syndrome (LFS) or Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) mutations...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28427978/prevalence-of-ponticulus-posticus-on-lateral-cephalometric-radiographs-its-association-with-cervicogenic-headache-and-a-review-of-literature
#7
Shahnaz S Tambawala, Freny R Karjodkar, Kaustubh Sansare, Digvijay Motghare, Isha Mishra, Shuddhodhan Gaikwad, Amaresh Chandra Dora
OBJECTIVES: The aim of this study was to calculate the prevalence of ponticulus posticus: a small bony bridge on the dorsal aspect of the Atlas on lateral digital cephalometric radiographs and classify it into a complete ring or an incomplete ring. The study also investigated its association with the presence or absence of cervicogenic headache in the examined population if any and presents a literature review on Ponticulus posticus. METHODS: The presence and types of ponticuli posticus were investigated on 500 digital lateral cephalograms and the same patients were questioned for a history of cervicogenic headache...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28425207/bcg-vaccination-induced-suppurative-lymphadenitis-four-signs-to-pay-attention-to
#8
Sang Oon Baek, Hyo Sun Ko, Hyun Ho Han
Suppurative lymphadenitis is one of the severe complication after BCG vaccination, but its diagnostic criteria and treatment guidelines have not yet been established. In this article, we describe a case of suppurative lymphadenitis caused by BCG vaccination and propose diagnostic criteria and treatment guidelines of the disease. The lymphadenitis was presented as skin involving mass and was completely extirpated. Pathological evaluation revealed a necrotising lymphadenitis, consistent with the diagnosis of BCG lymphadenitis...
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28424278/detection-of-hpv-subtypes-by-mass-spectrometry-in-ffpe-tissue-specimens-a-reliable-tool-for-routine-diagnostics
#9
Mark Kriegsmann, Petra Wandernoth, Katharina Lisenko, Rita Casadonte, Rémi Longuespée, Norbert Arens, Jörg Kriegsmann
AIMS: Human papilloma virus (HPV) infection is a causative agent for approximately 5% of all new cancer cases in humans. The virus is detected in cervical, anal, vaginal, penile, vulvar and head and neck cancers and has prognostic implications. Thus, test systems are required to detect high-risk but also low-risk HPV subtypes with high specificity and sensitivity in a time-effective and cost-effective manner. In the present study we developed a new mass spectrometry (MS)-based test system for the detection of HPV infections in formalin-fixed paraffin-embedded (FFPE) tissue samples...
May 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28419292/design-and-testing-of-2-novel-scores-that-predict-global-sagittal-alignment-utilizing-cervical-or-lumbar-plain-radiographs
#10
Ezequiel Goldschmidt, Federico Angriman, Bruno Ferreyro, Nitin Agarwal, James Zhou, Katherine Chen, Zachary J Tempel, Peter C Gerszten, Adam S Kanter, David O Okonkwo, Peter Passias, Justin Scheer, Themistocles Protopsaltis, Virginie Lafage, Renaud Lafage, Frank Schwab, Shay Bess, Chris Ames, Justin S Smith, Douglas Burton, D Kojo Hamilton
BACKGROUND: Global sagittal deformity is an established cause of disability. However, measurements of sagittal alignment are often ignored when patients present with symptoms localizing to the cervical or lumbar spine. OBJECTIVE: To develop scoring scales to predict the risk of sagittal malalignment in patients with only cervical or lumbar spine radiographs. METHODS: A retrospective review of a prospectively maintained multicenter adult spinal deformity database was performed...
April 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28413557/c2-primary-leiomyoma-in-an-immunocompetent-woman-a-case-report-and-review-of-literature
#11
Mohana Rao Patibandla, Madhukar T Nayak, A K Purohit, Megha Uppin, Sundaram Challa, Gokul Chowdary Addagada, Manisha Nukavarapu
Clinical case report and review of the literature. This is the first case of primary leiomyoma in an immunocompetent woman without previous history of uterine leiomyoma being reported in the literature to the best of our knowledge. Leiomyoma, a type of smooth muscle cell tumor, involving the vertebra is extremely rare. There were very few primary leiomyoma in patients with AIDS or in the immune-suppressed patients. This 48-year-old female came with H/o neck pain, weakness and bladder retention. On examination, tone increased in all four limbs, power on the right side of the limbs 4/5, power on the left upper limb 0/5, lower limb 3/5, left plantar was up going, decreased sensation over the left second cervical vertebra (C2) dermatome and all modalities decreased below C2...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413147/branchial-cleft-cyst-an-unusual-site-for-the-cervical-metastasis-of-nasopharyngeal-carcinoma
#12
Yu-Chang Liao, Mohamad Adel, Li-Yu Lee, Kai-Ping Chang
OBJECTIVE: Cancers found in the resected branchial cleft cyst are rare clinically but usually impose substantive diagnostic and treatment challenges for clinicians. METHODS: A 31-year-old man presented with a lateral neck mass that was suspected to be an inflammatory branchial cleft cyst. After excision, the pathologic specimen revealed a benign cystic appearance with a focus of undifferentiated carcinoma. Serologic tests for Epstein-Barr virus were negative. A positron emission tomography scan and upper aerodigestive tract endoscopies were negative for any other suspicious lesion...
April 13, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28412869/a-novel-salvialactomine-from-the-callus-culture-of-salvia-santolinifolia-boiss
#13
Tour Jan, Raiha Qadri, Beena Naqvi, Achyut Adhikari, Said Nadeem, Akhtar Muhammad
A novel compound Salvialactomine (1) along with two other unusual occurring natural products Pentatriacontanoic acid 1, 3-dihydroxypropyl ester (2) and 5-Methylflavone (3) were isolated from the callus of Salvia santolinifolia Boiss. Callus was initiated on MS medium containing NAA (0.5 mg/L) and further sub-cultured on MS medium supplemented with NAA with BA (0.5 + 1.5 mg/L). The structures of isolated compounds were determined by using mass spectrometry, 1D, and 2D-NMR techniques. Compounds 1, and 3 were tested for two different cancer cell lines, i...
April 17, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28411397/chondrosarcoma-like-metastasis-from-a-poorly-differentiated-uterine-cervical-squamous-cell-carcinoma-a-unique-morphology-and-diagnostic-pitfall-in-cytology
#14
Shohei Ikoma, Marlo Nicolas, Jaishree Jagirdar, Maria Luisa Policarpio-Nicolas
Rare cases of metastatic squamous cell carcinoma with chondroid differentiation from esophageal primary have been reported but none from the uterine cervix. Given the rarity of this phenomenon and potential diagnostic pitfall, we present this unusual case. The patient is a 25-year-old woman who presented with shortness of breath. Computerized tomography (CT) showed several lung and pleural-based nodules. CT-guided core biopsy with touch preparations were performed on the pleural-based nodule. The touch preparations showed large, spindle-to-oval shaped cells with pleomorphic nuclei embedded in metachromatic chondroid stroma...
April 14, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28409074/c2-and-greater-occipital-nerve-the-anatomic-and-functional-implications-in-spinal-surgery
#15
M Burhan Janjua, Peter L Zhou, Jeffrey P Greenfield, Ali A Baaj, Anthony Frempong-Boadu
INTRODUCTION: Posterior C1-C2 fusion is a highly successful treatment for atlantoaxial instability and other pathologies of the cervical spine, with fusion rates approaching 95%-100%. However, poor visualization of the lateral masses of C1 secondary to the course of the C2 nerve root along with blood loss from the venous plexus and compression of the C2 nerve from lateral mass screws are technical obstacles that can arise during surgery. Thus, sacrifice of the C2 nerve root has long since been debated in fusions involving the C1 and C2 vertebral bodies...
March 3, 2017: Curēus
https://www.readbyqxmd.com/read/28403658/in-vitro-growth-inhibition-and-cytotoxicity-of-euphorbia-caducifolia-against-four-human-cancer-cell-lines-and-its-phytochemical-characterisation
#16
Shaista Bano, Bina Shaheen Siddiqui, Ahsana Dar Farooq, Sabira Begum, Faheema Siddiqui, Muhammad Kashif, Mudassar Azhar
Several Euphorbia species have been used in folklore as cancer remedies, however, scientific studies on the cytotoxicity (in vitro studies) of Euphorbia caducifolia are lacking. In present study, anticancer potential of E. caducifolia aerial parts ethanol extract and its fractions were evaluated against human lung (NCI-H460), breast (MCF-7), prostate (PC-3) and cervical (HeLa) cancer cell lines, using sulphorhodamine-B in vitro cytotoxicity (in vitro studies) assay. The ethanol extract demonstrated growth inhibitory effect against all aforementioned cancer cell lines with IC50, 19-135 μg/mL and LC50, ~220 μg/mL, and its petroleum ether fraction obtained on bioactivity guided fraction showed highest activity with IC50, 28-70 μg/mL and LC50, 71 μg/mL against NCI-H460 and MCF-7 cell lines...
April 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28396813/chronic-lymphocytic-leukemia-as-an-unusual-cause-of-rapid-airway-compromise
#17
Adrian R Bersabe, Joshua T Romain, Erin E Ezzell, John S Renshaw
Chronic Lymphocytic Leukemia (CLL) is the most prevalent form of non-Hodgkin's lymphoma (NHL) in Western countries predominantly affecting adults over the age of 65. CLL is commonly indolent in nature but can present locally and aggressively at extranodal sites. Although CLL may commonly present with cervical lymphadenopathy, manifestation in nonlymphoid regions of the head and neck is not well described. CLL causing upper airway obstruction is even more uncommon. We describe a case of a patient with known history of CLL and stable lymphocytosis that developed an enlarging lymphoid base of tongue (BOT) mass resulting in rapid airway compromise...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28396722/laparoscopic-retrosternal-gastric-pull-up-for-fistulized-mediastinal-mass
#18
Benedetto Mungo, Arianna Barbetta, Anne O Lidor, Miloslawa Stem, Daniela Molena
We describe the case of a patient successfully reconstructed with laparoscopic retrosternal gastric pull-up after esophagectomy for unresectable posterior mediastinal inflammatory myofibroblastic tumor, eroding into the esophagus and compressing the airways. A partial esophagectomy with esophagostomy was performed for treatment of esophageal pleural fistula and empyema, while the airways were managed with the placement of an endobronchial stent. Gastrointestinal reconstruction was performed using a laparoscopic approach to create a retrosternal tunnel for gastric conduit pull-up and cervical anastomosis...
March 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28393508/-cervical-thymic-cyst-in-childhood
#19
M Haro-García, J Crespo Del Hierro, R de la Fuente-Cañibano, M A Alañón-Fernández
Cervical thymus cyst is a rare cause of neck mass in children. . Approximately 90 cases have been described, and just a few have been published in Spanish literature. They usually appear in early children and are diagnosed as brachial cyst. We report the case of a 6 year old boy with a swelling on the right side of the neck. The swelling had appeared a few months before. Ultrasound examination of a neck mass and MRI showed a cystic mass compatible with possible branchial cyst. Excision of the tumor was performed...
July 10, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/28393061/nasopharyngeal-carcinoma-with-cystic-cervical-metastasis-masquerading-as-branchial-cleft-cyst-a-potential-pitfall-in-diagnosis-and-management
#20
Lum Sai-Guan, Kong Min-Han, Ngan Kah-Wai, Mohd-Razif Mohamad-Yunus
INTRODUCTION: Most metastatic lymph nodes from head and neck malignancy are solid. Cystic nodes are found in 33% - 61% of carcinomas arise from Waldeyer's ring, of which only 1.8% - 8% originate are from the nasopharynx. Some cystic cervical metastases were initially presumed to be branchial cleft cyst. This case report aims to highlight the unusual presentation of cystic cervical metastasis secondary to nasopharyngeal carcinoma in a young adult. The histopathology, radiological features and management strategy were discussed...
March 2017: Iranian Journal of Otorhinolaryngology
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