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https://www.readbyqxmd.com/read/28089456/protective-effects-of-exercise-training-on-endothelial-dysfunction-induced-by-total-sleep-deprivation-in-healthy-subjects
#1
Fabien Sauvet, Pierrick J Arnal, Pierre Emmanuel Tardo-Dino, Catherine Drogou, Pascal Van Beers, Clément Bougard, Arnaud Rabat, Garance Dispersyn, Alexandra Malgoyre, Damien Leger, Danielle Gomez-Merino, Mounir Chennaoui
BACKGROUND: Sleep loss is a risk factor for cardiovascular events mediated through endothelial dysfunction. AIMS: To determine if 7weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men. METHODS: 16 subjects were examined during 40-h TSD, both before and after 7weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) and pulse wave velocity (PWV), blood pressure and heart rate (HR) were assessed before TSD (controlday), during TSD, and after one night of sleep recovery...
January 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28081532/cardiovascular-events-in-moderately-to-severely-obese-obstructive-sleep-apnea-patients-on-positive-airway-pressure-therapy
#2
Anna Maria Marotta, Jean-Christian Borel, Louis M Galerneau, Renaud Tamisier, Maria R Bonsignore, Jean Louis Pépin
BACKGROUND: In moderately to severely obese patients with obstructive sleep apnea (OSA), the effects of long-term positive airway pressure (PAP) treatment on cardiovascular risk are poorly defined. PURPOSE: To assess the effect of continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) on the occurrence of cardiovascular events in obese OSA patients. METHODS: We performed a noninterventional observational study in obese OSA patients recruited between 2007 and 2010 at the Sleep Center, University of Grenoble, treated with CPAP or NIV, and followed for 5...
January 13, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28078997/lipoprotein-a-and-cardiovascular-risk-the-show-must-go-on
#3
Niki Katsiki, Khalid Al-Rasadi, Dimitri P Mikhailidis
Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity. Several established and emerging cardiovascular (CV) risk factors including age, gender, ethnicity, smoking, dyslipidemia, hypertension, obesity, type 2 diabetes mellitus, alcohol consumption, arterial stiffness and hyperuricemia have been linked to Lp(a) metabolism. Apart from CHD, Lp(a) has been also associated with non-cardiac vascular diseases and diseases associated with increased CV risk such as chronic kidney disease, metabolic syndrome, non-alcoholic fatty liver disease, erectile dysfunction, obstructive sleep apnea syndrome, inflammatory bowel diseases and human immunodeficiency virus infection...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28078487/the-role-of-the-nox4-derived-ros-mediated-rhoa-rho-kinase-pathway-in-rat-hypertension-induced-by-chronic-intermittent-hypoxia
#4
Wen Lu, Jing Kang, Ke Hu, Si Tang, Xiufang Zhou, Lifang Xu, Yuanyuan Li, Shuhui Yu
BACKGROUND: Obstructive sleep apnea syndrome, which is a risk factor for resistant hypertension, is characterized by chronic intermittent hypoxia (CIH) and is associated with many cardiovascular diseases. CIH elicits systemic oxidative stress and sympathetic hyperactivity, which lead to hypertension. Rho kinases (ROCKs) are considered to be major effectors of the small GTPase RhoA and have been extensively studied in the cardiovascular field. Upregulation of the RhoA/ROCK signaling cascade is observed in various cardiovascular disorders, such as atherosclerosis, pulmonary hypertension, and stroke...
January 11, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28073039/effect-of-sleep-problems-on-depressive-disorders-1-year-after-developing-acute-coronary-syndrome-the-k-depacs-study
#5
Jae-Min Kim, Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin-Sang Yoon
INTRODUCTION: This study investigated the effects of sleep disturbance evaluated within 2 weeks after patients developed acute coronary syndrome (ACS) on depressive disorders at the 1-year follow-up. METHODS: A total of 1152 patients were recruited consecutively within 2 weeks after a confirmed ACS episode, and 828 were followed 1 year later. Sleep disturbances were evaluated at baseline using the Leeds Sleep Evaluation Questionnaire (LSEQ), which subjectively assesses four sleep factors...
January 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28069600/cpap-did-not-reduce-cardiovascular-events-in-patients-with-coronary-or-cerebrovascular-disease-and-moderate-to-severe-obstructive-sleep-apnoea
#6
Yüksel Peker, Patrick J Strollo
No abstract text is available yet for this article.
January 9, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28065769/habitual-and-recent-sleep-durations-graded-and-interactive-risk-for-impaired-glycemic-control-in-a-biracial-population
#7
Donald L Bliwise, Sophia A Greer, Michael K Scullin, Lawrence S Phillips
BACKGROUND AND AIMS: We examined how habitual sleep duration interacts with recent sleep (two nights) to predict morning oral glucose tolerance test results. We hypothesized short habitual and recent sleep durations would be additive for poor glucose control. METHODS: A biracial population of adults (n = 1,559) without known diabetes and recruited from the workforce of two urban universities was assessed for glycated hemoglobin and underwent oral glucose tolerance testing...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#8
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28065222/the-effect-of-sleep-deprivation-on-coronary-heart-disease
#9
Yuan Rong, Wang Jie, Guo Li-Li
Sleep deprivation (SD) has been associated with an increased morbidity and mortality of coronary heart disease (CHD). SD could induce autonomic nervous dysfunction, hypertension, arrhythmia, hormonal dysregulation, oxidative stress, endothelial dysfunction, inflammation and metabolic disorder in CHD patients. This paper reviewed the study results of SD in clinical trials and animal experiments and concluded that SD was associated with cardiovascular risk factors, which aggravated CHD in pathogenesis and outcomes...
November 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28060086/sex-specific-associations-between-self-reported-sleep-duration-cardiovascular-disease-hypertension-and-mortality-in-an-elderly-population
#10
Anders Broström, Ake Wahlin, Urban Alehagen, Martin Ulander, Peter Johansson
BACKGROUND: Both short and long sleep durations have been associated to increased mortality. Knowledge about sex-specific differences among elderly regarding associations between sleep duration, cardiovascular health, and mortality is sparse. OBJECTIVE: The aims of this study are to examine the association between self-reported sleep duration and mortality and to investigate whether this association is sex specific and/or moderated by cardiovascular morbidity, and also to explore potential mediators of sleep duration effects on mortality...
January 5, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28057921/no-modifying-effect-of-education-level-on-the-association-between-lifestyle-behaviors-and-cardiovascular-mortality-the-japan-collaborative-cohort-study
#11
Eri Eguchi, Hiroyasu Iso, Kaori Honjo, Hiroshi Yatsuya, Akiko Tamakoshi
We examined the effect of education level on the association between healthy lifestyle behaviors and cardiovascular mortality in the Japanese population. A total of 42,647 community-based men and women aged 40-79 years were enrolled at baseline (1988-1990), followed through 2009. The components of the healthy lifestyle score included the intake of fruits, fish, and milk; body mass index; exercise; avoidance of smoking; moderate alcohol intake; and moderate sleep duration. During the 19.3 years of follow-up, 8,314 all-cause and 2,377 total cardiovascular mortality cases were noted...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057852/endothelin-1-and-et-receptors-impair-left-ventricular-function-by-mediated-coronary-arteries-dysfunction-in-chronic-intermittent-hypoxia-rats
#12
Jin-Wei Wang, Ai-Ying Li, Qiu-Hong Guo, Ya-Jing Guo, James W Weiss, En-Sheng Ji
Obstructive sleep apnea (OSA) results in cardiac dysfunction and vascular endothelium injury. Chronic intermittent hypoxia (CIH), the main characteristic of OSAS, is considered to be mainly responsible for cardiovascular system impairment. This study is aimed to evaluate the role of endothelin-1(ET-1) system in coronary injury and cardiac dysfunction in CIH rats. In our study, Sprague-Dawley rats were exposed to CIH (FiO2 9% for 1.5 min, repeated every 3 min for 8 h/d, 7 days/week for 3 weeks). After 3 weeks, the left ventricular developed pressure (LVDP) and coronary resistance (CR) were measured with the langendorff mode in isolated hearts...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28056799/epidemiological-characteristics-and-gender-specific-differences-of-obstructive-sleep-apnea-in-a-chinese-hypertensive-population-a-cross-sectional-study
#13
Anping Cai, Yingling Zhou, Jiawei Zhang, Qi Zhong, Rui Wang, Ling Wang
BACKGROUND: Obstructive sleep apnea (OSA) is associated with an increase in the prevalence and incidence of hypertension and cardiovascular diseases. Data about epidemiological characteristics of OSA in Chinese hypertensive populations is limited. METHODS: Hypertensive subjects without a prior diagnosis of OSA were recruited, and the apnea-hyponea index (AHI) was assessed by polysomnography. Comparisons were performed between subjects without OSA and with different degrees of OSA...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28055285/sleep-disordered-breathing-is-associated-with-higher
#14
Peter D Ahiawodzi, Richard A Kerber, Kira C Taylor, Frank D Groves, Elizabeth O'Brien, Joachim H Ix, Jorge R Kizer, Luc Djoussé, Russell P Tracy, Anne B Newman, David S Siscovick, John Robbins, K Mukamal
CONTEXT: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. OBJECTIVE: To investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress- and CML. MATERIALS AND METHODS: 1002 participants in the Cardiovascular Health Study (CHS) were studied. RESULTS: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1...
January 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28052522/assessment-of-carotid-artery-intima-media-thickness-in-patients-with-obstructive-sleep-apnea
#15
Li-Jen Liao, Tsung-Yi Cho, Tsung-Wei Huang
OBJECTIVE: This study compares the carotid intima-media thickness (CIMT) in different severity of obstructive sleep apnea (OSA) patients, and assesses the role of OSA in carotid artery vasculopathy with control of multiple co-morbidities. STUDY DESIGN: Prospective case-control study SETTING: Tertiary referral center PARTICIPANTS: This study recruited 36 volunteers without the complaints of sleep-disordered breathing, 27 patients with mild-moderate OSA and 39 patients with severe OSA...
January 4, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28051821/energy-drink-consumption-in-italian-university-students-food-habits-and-lifestyle
#16
V Vitiello, L Diolordi, M Pirrone, L M Donini, V Del Balzo
OBJECTIVES: The aim of this study was to investigate the consumption of ED (Energy drink) among young people, both alone and in association with alcohol, as well as the food habits and lifestyle of ED consumers. MATERIALS AND METHODS: An anonymous closed-ended questionnaire, was administered to a sample of students. The questionnaire is composed of 30 questions with multiple answers. The students, who come from different regions in Italy, were enrolled at two Italian Universities: Rome and Cagliari...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28049935/work-sleep-and-cholesterol-levels-of-u-s-long-haul-truck-drivers
#17
Michael K Lemke, Yorghos Apostolopoulos, Adam Hege, Laurie Wideman, Sevil Sonmez
Long-haul truck drivers in the United States experience elevated cardiovascular health risks, possibly due to hypercholesterolemia. The current study has two objectives: 1) to generate a cholesterol profile for U.S. long-haul truck drivers; and 2) to determine the influence of work organization characteristics and sleep quality and duration on cholesterol levels of long-haul truck drivers.Survey and biometric data were collected from 262 long-haul truck drivers. Descriptive analyses were performed for demographic, work organization, sleep, and cholesterol measures...
December 30, 2016: Industrial Health
https://www.readbyqxmd.com/read/28049126/comorbidities-in-interstitial-lung-diseases
#18
REVIEW
George A Margaritopoulos, Katerina M Antoniou, Athol U Wells
Fibrosing lung disorders include a large number of diseases with diverse behaviour. Patients can die because of the progression of their illness, remain stable or even improve after appropriate treatment has been instituted. Comorbidities, such as acute and chronic infection, gastro-oesophageal reflux, pulmonary hypertension, lung cancer, cardiovascular diseases, and obstructive sleep apnoea, can pre-exist or develop at any time during the course of the disease and, if unidentified and untreated, may impair quality of life, impact upon the respiratory status of the patients, and ultimately lead to disease progression and death...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28049125/pre-operative-screening-for-obstructive-sleep-apnoea
#19
REVIEW
Johan Verbraecken, Jan Hedner, Thomas Penzel
Sleep disordered breathing, especially obstructive sleep apnoea (OSA), has a high and increasing prevalence. Depending on the apnoea and hypopnoea scoring criteria used, and depending on the sex and age of the subjects investigated, prevalence varies between 3% and 49% of the general population. These varying prevalences need to be reflected when considering screening for OSA. OSA is a cardiovascular risk factor and patients are at risk when undergoing medical interventions such as surgery. Screening for OSA before anaesthesia and surgical interventions is increasingly considered...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28041720/atrial-fibrillation-is-a-major-cause-of-stroke-in-apneic-patients-a-prospective-study
#20
M Poli, P Philip, J Taillard, S Debruxelles, P Renou, J M Orgogozo, F Rouanet, I Sibon
OBJECTIVES: Large prospective studies have established that sleep-disordered breathing (SDB) is associated with an increased incidence of cardiovascular and cerebrovascular diseases. Heterogeneous results have been published about SDB and ischaemic stroke mechanism. The aim of this study was to evaluate the relationship between poststroke apneic syndrome and stroke aetiologies according to the ASCO classification. METHODS: A total of 134 patients with acute ischaemic cerebrovascular events were prospectively included...
March 4, 2016: Sleep Medicine
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