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Fentanyl buccal tablet

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https://www.readbyqxmd.com/read/27693898/effendys-fentanyl-buccal-tablet-for-the-relief-of-episodic-breathlessness-in-patients-with-advanced-cancer-a-multicenter-open-label-randomized-morphine-controlled-crossover-phase-ii-trial
#1
Steffen T Simon, Marianne Kloke, Bernd Alt-Epping, Jan Gärtner, Martin Hellmich, Rebecca Hein, Maren Piel, Oliver A Cornely, Friedemann Nauck, Raymond Voltz
CONTEXT: Episodic breathlessness is a frequent and burdensome symptom in cancer patients but pharmacological treatment is limited. OBJECTIVES: To determine time to onset, efficacy, feasibility and safety of transmucosal fentanyl in comparison to immediate-release morphine (IRM) for the relief of episodic breathlessness. METHODS: Phase II, investigator initiated, multicenter, open-label, randomized, morphine-controlled, crossover trial with open-label titration of fentanyl buccal tablet (FBT) in inpatients with incurable cancer...
September 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/26689067/-understanding-oral-and-nasal-mucosal-absorption-of-fentanyl-and-rectal-absorption-of-buprenorphine
#2
Naohito Shimoyama, Megumi Shimoyama, Yukino Kubota, Yoko Kato
One of the key issues in the treatment of pain is to choose the appropriate route and dosage form of analgesics for each individual patient in pain. New drug forms of fentanyl absorbed by oral or nasal mucosa, and buprenorphine absorbed by rectal mucosa are described in this chapter. Only lipophilic opioids such as fentanyl and buprenorphine can be absorbed via the mucosa of oral or nasal cavity of the human body. The T max of rapid onset opioids (ROO) such as fentanyl buccal or sublingual tablets is the fastest among various dosage forms of opioid analgesics...
November 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26526136/recent-and-upcoming-approaches-in-the-management-of-cancer-breakthrough-pain
#3
Jo Noble-Gresty
The pharmacokinetics of the traditional oral opioids do not match the time course of breakthrough cancer pain, a common and distinct component of cancer pain which has a negative impact on quality of life for the patient.Fentanyl and alfentanil are potent, lipophilic, fast acting opioids with short durations of action and consequently more appropriate for the treatment of breakthrough cancer pain. These agents are ideal for oral transmucosal or nasal transmucosal administration.There are now four licensed preparations of fentanyl in the UK for the treatment of cancer breakthrough pain; lozenge, buccal tablet, sublingual tablet and nasal spray...
October 2010: Reviews in Pain
https://www.readbyqxmd.com/read/26377306/a-phase-ii-study-on-the-efficacy-and-safety-of-procedural-analgesia-with-fentanyl-buccal-tablet-in-cancer-patients-for-the-placement-of-indwelling-central-venous-access-systems
#4
R Bortolussi, P Zotti, M Matovic, A Morabito, C Bertuzzi, M Caserta, F Fabiani, A Fracasso, C Santantonio, C Zanier, A Roscetti, J Polesel, D Gussetti, S Bedin, A M Colussi, D Fantin
BACKGROUND: Pain in cancer patients is often related to oncologic therapies and diagnostic procedures. The placement of fully implantable venous access systems is a very common procedure in oncology patients. Local anaesthesia is the method most commonly used to overcome pain related to this surgical procedure, but the local anaesthetic may be unable to completely eradicate all pain. This study investigates the effectiveness and safety of fentanyl buccal tablet (FBT), administered by OraVescent® technology, in reducing procedural pain related to the placement of indwelling central venous access systems (Ports) in opioid-naïve cancer patients...
April 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/26368648/transmucosal-immediate-release-fentanyl-for-breakthrough-cancer-pain-opportunities-and-challenges-for-use-in-palliative-care
#5
Andrew Chang, Eric J Roeland, Rabia S Atayee, Carolyn Revta, Joseph D Ma
Opioids are used to treat breakthrough cancer pain (BTCP) and can be classified by relative duration and onset of action. Regulatory approvals of numerous transmucosal immediate-release fentanyl (TIRF) formulations provide alternative options to palliative care-trained providers in the management of BTCP. TIRFs have been formulated as a sublingual tablet, sublingual spray, intranasal spray, pectin-based nasal spray, buccal tablet, and buccal soluble film. Differences exist between TIRFs regarding formulation design and dosing to treat BTCP...
September 2015: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/26303188/fentanyl-buccal-tablet-vs-oral-morphine-in-doses-proportional-to-the-basal-opioid-regimen-for-the-management-of-breakthrough-cancer-pain-a-randomized-crossover-comparison-study
#6
RANDOMIZED CONTROLLED TRIAL
Sebastiano Mercadante, Claudio Adile, Arturo Cuomo, Federica Aielli, Andrea Cortegiani, Alessandra Casuccio, Giampiero Porzio
CONTEXT: Fentanyl products have shown superiority to oral opioids for the management of breakthrough cancer pain (BTcP). However, these studies did not use appropriate patient selection, and drugs have been compared by using different rationales. OBJECTIVES: The aim of this randomized, crossover, controlled study was to compare efficacy and safety of fentanyl buccal tablets (FBTs) and oral morphine (OM), given in doses proportional to opioid daily doses. METHODS: Cancer patients with pain receiving ≥60 mg or more of oral morphine equivalents per day and presenting with ≤3 episodes of BTcP per day were included...
November 2015: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/26179823/pictorial-prescribing-reduces-fentanyl-drug-administration-errors-a-simulated-controlled-study
#7
Stephen W Booth, Maria Gloag, Sara Kinna, Andrew Bell, Joanna L C Wheble, Daniel W Wheeler
OBJECTIVES: Transmucosal fentanyl is used to treat transient exacerbations of cancer pain. Several immediate release products are available, presented as intranasal sprays, sublingual and buccal tablets, or lozenges. These are not interchangeable, creating potential for medication errors. We compared the incidence of medication errors in a simulated scenario using handwritten drug charts and charts labelled with preprinted self-adhesive stickers with full pictorial fentanyl prescriptions...
July 15, 2015: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/26009799/fentanyl-buccal-tablet-a-new-breakthrough-pain-medication-in-early-management-of-severe-vaso-occlusive-crisis-in-sickle-cell-disease
#8
Lucia De Franceschi, Paolo Mura, Vittorio Schweiger, Elisa Vencato, Francesca Maria Quaglia, Letizia Delmonte, Maurizio Evangelista, Enrico Polati, Oliviero Olivieri, Gabriele Finco
BACKGROUND: Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder. The principal clinical manifestations of SCD are the chronic hemolytic anemia and the acute vaso-occlusive crisis (VOCs), which are mainly characterized by ischemic/reperfusion tissue injury. Pain is the main symptom of VOCs, and its management is still a challenge for hematologists, requiring a multidisciplinary approach. METHODS: We carried out a crossover study on adult SCD patients, who received two different types of multimodal analgesia during two separate severe VOCs with time interval between VOCs of at least 6 months...
July 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/25963705/-efficacy-of-a-fentanyl-citrate-buccal-tablet-for-esophageal-cancer-pain-management-in-a-patient-unable-to-take-oral-medication
#9
Yoshinori Fujimura, Osamu Nakahara, Shigeki Ohshima, Hideo Baba
We report a case ofa 60-year old male esophageal cancer patient who was unable to take oral medication, but was successfully treated using a fentanyl citrate buccal tablet. The patient survived a suicide attempt as a youth in which he ingested poison, but was left with a stricture of the esophagus. It became difficult for him to take nutrition orally, and he underwent an esophageal bypass operation, although he still required frequent endoscopic esophageal dilation. He subsequently presented with an anastomotic stenosis due to anastomotic leakage, and oral intake became completely impossible...
April 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/25556611/improved-patient-functioning-after-treatment-of-breakthrough-cancer-pain-an-open-label-study-of-fentanyl-buccal-tablet-in-patients-with-cancer-pain
#10
RANDOMIZED CONTROLLED TRIAL
Andrew Davies, Ulrich R Kleeberg, Jerzy Jarosz, Sebastiano Mercadante, Philippe Poulain, Tony O'Brien, Hélène Schneid, Hans G Kress
PURPOSE: This open-label study evaluated the effects of fentanyl buccal tablet (FBT) on functioning and mood in cancer patients with breakthrough cancer pain (BTcP). METHODS: Opioid-tolerant patients in seven European countries with up to four BTcP episodes/day received FBT doses (100-800 μg) identified during open-label titration to treat up to eight BTcP episodes during an open-label treatment period. In countries where FBT was not commercially available, patients could enter an open-label continuation phase...
July 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/25381384/breakthrough-pain-management-using-fentanyl-buccal-tablet-fbt-in-combination-with-around-the-clock-atc-opioids-based-on-the-efficacy-and-safety-of-fbt-and-its-relationship-with-atc-opioids-results-from-an-open-label-multi-center-study-in-japanese-cancer-patients
#11
MULTICENTER STUDY
Chizuko Takigawa, Fumio Goto, Shigeru Tanda, Yasuo Shima, Kinomi Yomiya, Motohiro Matoba, Isamu Adachi, Tetsusuke Yoshimoto, Kenji Eguchi
OBJECTIVE: Rapid analgesic onset opioids, particularly fentanyl buccal tablet, is preferable for managing breakthrough pain. The efficacy and safety of fentanyl buccal tablet and its association with around-the-clock opioids needs to be explored with an option of dose adjustments, more closely reflecting administration in clinical practice. The aim of the study was to assess the safety and efficacy of fentanyl buccal tablet in breakthrough pain management in combination with around-the-clock opioids with the dose adjustment option, and explore the dose adjustment's influence on breakthrough pain management using detailed evaluation...
January 2015: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/25359295/fentanyl-buccal-tablet-for-the-treatment-of-cancer-related-breakthrough-pain
#12
REVIEW
Sebastiano Mercadante
Fentanyl buccal tablet (FBT) (FENTORA) is indicated for the management of breakthrough pain (BTP) in patients with cancer pain and who are tolerant to ≥60 mg of oral morphine equivalents, at least with the current availability of the minimal strength of 100 μg. FBT uses the OraVescent technology to further increase the rate and extent of absorption of fentanyl. Short-term, randomized, controlled, clinical studies of FBT in patients with cancer pain have shown the efficacy of FBT in the management of breakthrough cancer pain...
January 2015: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/25181451/pan-european-open-label-dose-titration-study-of-fentanyl-buccal-tablet-in-patients-with-breakthrough-cancer-pain
#13
RANDOMIZED CONTROLLED TRIAL
U R Kleeberg, A Davies, J Jarosz, S Mercadante, P Poulain, T O'Brien, H Schneid, H G Kress
BACKGROUND: Fentanyl buccal tablet (FBT), a rapid onset opioid used to treat breakthrough cancer pain, must be titrated to an effective dose that provides adequate analgesia and minimizes undesirable events. This open-label, randomized study compared the percentage of patients achieving an effective dose of FBT when starting titration at 100 or 200 μg. METHODS: Opioid-tolerant patients with chronic cancer-related pain who experienced up to four breakthrough pain episodes daily were randomized to a starting dose of 100 or 200 μg for the titration period...
April 2015: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/24969120/indicators-of-drug-seeking-aberrant-behaviours-the-feasibility-of-use-in-observational-post-marketing-cohort-studies-for-risk-management
#14
Deborah Layton, Vicki Osborne, Mohammad Al-Shukri, Saad A W Shakir
BACKGROUND: Problematic prescription drug use is reflected by or associated with drug-seeking aberrant behaviours. Research gaps include lack of post-marketing evidence and instruments. As part of the pharmacovigilance requirements, a risk management plan was developed for fentanyl buccal tablets (FEBT) by the manufacturer, with an additional pharmacovigilance activity requested by the regulatory authority, to investigate the risks of misuse, abuse, criminal use, off-label use and accidental exposure to FEBT after the product became commercially available...
August 2014: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/24944071/a-review-of-rapid-onset-opioids-for-breakthrough-pain-in-patients-with-cancer
#15
REVIEW
Steven M Simon, Lee S Schwartzberg
Pain management in patients with cancer remains suboptimal. Breakthrough pain (BTP) is characterized by abrupt onset of severe pain in a background of otherwise stable managed pain and presents a substantial burden to patients, as it disrupts activities and quality of life. Rapid-onset opioids (ROOs), with an appropriate onset and duration of effect, provide new options for effective and well-tolerated management of BTP. All currently available ROOs are various formulations of transmucosal immediate-release fentanyl (TIRF) and, although they were originally developed and approved for use in children before painful procedures, are only approved for use in opioid-tolerant adult patients with cancer and BTP...
May 2014: Journal of Opioid Management
https://www.readbyqxmd.com/read/24666664/aberrant-drug-related-behavior-observed-during-a-12-week-open-label-extension-period-of-a-study-involving-patients-taking-chronic-opioid-therapy-for-persistent-pain-and-fentanyl-buccal-tablet-or-traditional-short-acting-opioid-for-breakthrough-pain
#16
RANDOMIZED CONTROLLED TRIAL
Steven D Passik, Arvind Narayana, Ronghua Yang
OBJECTIVE: Evaluate aberrant drug-related behaviors in patients administering fentanyl buccal tablet or traditional short-acting opioids for breakthrough pain. DESIGN: Twelve-week open-label extension. SETTING: Forty-two US sites. SUBJECTS: Opioid-tolerant patients with chronic pain who completed the previous randomized, double-blind, crossover portion of a study comparing fentanyl buccal tablet and immediate-release oxycodone for treatment of breakthrough pain...
August 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/24654058/various-formulations-of-oral-transmucosal-fentanyl-for-breakthrough-cancer-pain-an-indirect-mixed-treatment-comparison-meta-analysis
#17
REVIEW
Ravi Jandhyala, John Fullarton
OBJECTIVE: To compare the efficacy of fentanyl effervescent buccal tablet (FBT), sublingual oral transmucosal fentanyl citrate (ODT) and compressed lozenge oral transmucosal fentanyl citrate (OTFC) for the treatment of breakthrough cancer pain (BTcP). METHODS: Randomised, controlled trials of FBT, ODT and OTFC in the treatment of BTcP were identified via a systematic literature review. Pain intensity difference (PID) data were extracted from all eligible studies for all recorded time points...
June 2012: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/24653483/how-practical-are-transmucosal-fentanyl-products-for-breakthrough-cancer-pain-novel-use-of-placebo-formulations-to-survey-user-opinion
#18
Ruth England, Matthew Maddocks, Cathann Manderson, Sonja Zadora-Chrzastowska, Andrew Wilcock
BACKGROUND: Three transmucosal fentanyl products have recently been licensed for cancer-related breakthrough pain: a sublingual tablet, a buccal/sublingual tablet and a nasal spray. Limited comparative data hinder identifying the most appropriate to use and adopt onto a service formulary. However, the availability of placebo formulations provides a unique opportunity to compare the practical aspects of their use. METHODS: 30 patients with cancer accessed and administered a placebo of each product and were asked to rate them using 1-7 Likert agree-disagree scales and free-text responses, with regard to ease of access and administration, palatability and overall impression...
December 2011: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/24645764/fentanyl-buccal-tablets-for-the-treatment-of-breakthrough-pain
#19
Sebastiano Mercadante
SUMMARY Fentanyl buccal tablets (FBT) have been designed to treat breakthrough pain (BTP) in patients who are already receiving, and who are tolerant to, opioid therapy for their underlying persistent pain. FBT are a formulation that uses an effervescent drug delivery system to enhance penetration across the buccal mucosa. OraVescent technology provides an effervescent reaction that liberates carbon dioxide in the buccal cavity. This reaction causes an initial decrease in pH, which facilitates solubilization, thus driving fentanyl into solution...
November 2011: Pain Management
https://www.readbyqxmd.com/read/24639603/management-of-breakthrough-pain-in-children-with-cancer
#20
REVIEW
Stefan J Friedrichsdorf, Andrea Postier
Breakthrough pain in children with cancer is an exacerbation of severe pain that occurs over a background of otherwise controlled pain. There are no randomized controlled trials in the management of breakthrough pain in children with cancer, and limited data and considerable experience indicate that breakthrough pain in this pediatric patient group is common, underassessed, and undertreated. An ideal therapeutic agent would be rapid in onset, have a relatively short duration, and would be easy to administer...
2014: Journal of Pain Research
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