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Rens Verhagen, P Richard Schuurman, Pepijn van den Munckhof, M Fiorella Contarino, Rob M A de Bie, Lo J Bour
OBJECTIVE: The correspondence between the anatomical STN and the STN observed in T2-weigthed MRI images used for deep brain stimulation (DBS) targeting remains unclear. Using a new method, we compared the STN borders seen on MRI images with those estimated by intraoperative microelectrode recordings (MER). APPROACH: We developed a method to automatically generate a detailed estimation of STN shape and the location of its borders, based on multiple-channel MER measurements...
October 14, 2016: Journal of Neural Engineering
F Legou, V Tacher, T Damy, V Planté-Bordeneuve, S Rappeneau, N Benhaiem, J Rosso, E Itti, A Luciani, H Kobeiter, A Rahmouni, J-F Deux
PURPOSE: To detect if a difference of T2 ratio, defined as the signal intensity (SI) of the myocardium divided by the SI of the skeletal muscle on T2-weigthed cardiac magnetic resonance (CMR) imaging, exists between patients with systemic amyloidosis, by comparison to control subjects. To determine if a relationship exists between T2 ratio and the overall mortality. MATERIALS AND METHODS: CMR imaging examinations of 73 consecutive patients (48 men, 25 women; mean age, 63 years±15[SD]) with amyloidosis and suspicion of CA and 27 control subjects were retrospectively analyzed after institutional review board approval...
September 28, 2016: Diagnostic and Interventional Imaging
Giovanni Veronesi, Simona Giampaoli, Francesco Gianfagna, Luigi Palmieri, Diego Vanuzzo, Guido Grassi, Giancarlo Cesana, Marco M Ferrario
OBJECTIVE: To evaluate the clinical utility of the CAMUNI-MATISS 20-year risk score, recently validated for the Italian population, as additional screening tool for individuals at "low" (ESC-SCORE Project predicted 10-year risk ≤ 1%; no preventive action), "intermediate" (ESC-SCORE 1-4%; lifestyle modification/statin treatment) and "high" risk (ESC-SCORE≥ 4% or diabetes; statin treatment) according to the Italian regulation. DESIGN AND METHOD: 40-65 years old initially CVD-free participants to 7 population-based cohorts enrolled in Northern and Central Italy between 1986 and 1996 were followed-up (median 16 years, IQR: 12-20) to the first occurrence of coronary event or ischemic stroke (fatal or non-fatal), coronary or carotid revascularizations...
September 2016: Journal of Hypertension
M Baron, F-X Nouhaud, C Delcourt, P Grise, C Pfister, J-N Cornu, L Sibert
AIM: Holmium laser enucleation of prostate (HoLEP) is renowned for the difficulty of its learning curve. Our aim was to evaluate the interest of a three-step tutorial in the HoLEP learning curve, in a university center. METHODS: It is a retrospective, monocentric study of the 82 first procedures done consecutively by the same operator with a proctoring in early experience and after 40 procedures. For all patients were noted: enucleation efficiency (g/min), morcellation efficiency (g/min), percentage of enucleated tissue (enucleated tissue/adenome weigth evaluated by ultrasonography...
September 2016: Progrès en Urologie
Yoon-Ho Kim, Sung-In Kim, Seongjun Park, Sung Hwan Hong, Sun G Chung
BACKGROUND: We theorized that active cervical extension should influence the position of the nucleus pulposus (NP) within the intervertebral disk (IVD) in the sagittal plane. Although several studies on the lumbar IVD have been conducted, there are no quantitative data for in vivo positional changes of the NP in the cervical IVD. OBJECTIVE: To evaluate the influence and mechanism of cervical extension on the deformation and migration of IVD and NP in the sagittal plane and understand underlying mechanisms of the extension maneuver...
September 6, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
F Uyttenhove, C Langlois, P Collinet, C Rubod, P Verpillat, J Bigot, O Kerdraon, N Faye
OBJECTIVES: To evaluate the interest of rectal and vaginal filling in vaginal and recto-sigmoid endometriosis with MR imaging. To compare the results between a senior and a junior radiologist review. METHODS: Sixty-seven patients with clinically suspected deep infiltrating endometriosis were included in our MRI protocol consisting of repeated T2-weigthed sequences (axial and sagittal) before and after rectal and vaginal marking with ultrasonography gel. Vaginal and recto-sigmoid endometriosis lesions were analyzed before and after opacification...
May 20, 2016: Gynécologie, Obstétrique & Fertilité
Jana Jiráčková, Alena Šmahelová
Victoza (liraglutide) is a modern antidiabetic drug of GLP1 (glucagone like peptide) analogue group; since 2009 registered in Czech republic. VICTOZA is used in therapy of type 2 diabetic patients with preserved endougenous insulin secretion, usually in combination with other peroral antidiabetic drugs or with basal insulin. VICTOZA is applied once a day subcutaneously. The characteristical antidiabetic effect with β cell protection is enhanced with supportive weigth reduction effect. Positive cardiovascular influence is expected, however data from recent studies are not available at this time...
March 2016: Vnitr̆ní Lékar̆ství
Roberta Fusco, Mario Sansone, Mario Petrillo, Sergio Venanzio Setola, Vincenza Granata, Gerardo Botti, Sisto Perdonà, Valentina Borzillo, Paolo Muto, Antonella Petrillo
INTRODUCTION: Early promising data suggest that combined use of both morphological and functional MRI (multi-parametric MR, mpMRI) including MRSI, DWI and DCE may be of additional value for prostate cancer localization and its local staging. The objective of this paper is to evaluate the diagnostic performance of mpMRI in the detection of prostate cancer. METHODS: Thirty-one consecutive male patients were screened to be enrolled in a single center prospective observational study...
September 2016: Magnetic Resonance Imaging
Merve Caliskan, Rasim Mogulkoc, Abdulkerim Kasim Baltaci, Esma Menevse
The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal were anesthesized and carotid arteried were clemped for 20 min and reperfusion (7 days). 3-DiOHF + Ischemia-reperfusion; DiOHF was given to animals as 10 mg/kg by intraperitoneal. 4- Ischemia + DiOHF + Reperfusion; 5- Ischemia-reperfusion + DiOHF...
July 2016: Neurochemical Research
Mario Petrillo, Roberta Fusco, Orlando Catalano, Mario Sansone, Antonio Avallone, Paolo Delrio, Biagio Pecori, Fabiana Tatangelo, Antonella Petrillo
To evaluate MRI for neoadjuvant therapy response assessment in locally advanced rectal cancer (LARC) using dynamic contrast enhanced-MRI (DCE-MRI) and diffusion weighted imaging (DWI), we have compared magnetic resonance volumetry based on DCE-MRI (V(DCE)) and on DWI (V(DWI)) scans with conventional T2-weighted volumetry (V(C)) in LARC patients after neoadjuvant therapy. Twenty-nine patients with LARC underwent MR examination before and after neoadjuvant therapy. A manual segmentation was performed on DCE-MR postcontrast images, on DWI (b-value 800 s/mm(2)), and on conventional T2-weighted images by two radiologists...
2015: BioMed Research International
A Valle, J Alvarado-Mesén, M E Lanio, C Álvarez, J A R G Barbosa, I F Pazos
Actinoporins are basic pore-forming proteins produced by sea anemones, with molecular weight around 20 kDa showing high affinity for sphingomyelin-containing membranes. Most sea anemones produce more than one actinoporin isoform differing in isoelectric point, molecular weigth and cytolytic activity. Examples of sea anemones with actinoporin isoforms are: Actinia equina with at least five isoform genes; Actinia tenebrosa, three isoforms; Actinia fragacea, five isoforms; Actineria villosa, Phyllodiscus semoni, Stichodactyla helianthus and Oulactis orientalis, with two isoforms each one, and Heteractis crispa with twenty-four isoforms...
September 2015: Toxicon: Official Journal of the International Society on Toxinology
Miao Yu, Linyuan Zhang, Peihuan Qiao, Bing Chang
OBJECTIVE: To explore the relationship and possible mechanisms between testicular oxidative injury caused by DBP and the testosterone synthesis pathway. METHODS: Twenty-four male Wistar male rats (4-wk-old) were randomly divided into 4 groups, three doses of DBP (80, 200 and 500 mg/kg) groups and a vehicle (corn oil) control group, 6 animals each. The rats were respectively administered by gavage once a day for four weeks. They were sacrificed after 4 weeks treatment and the body weights, testis, epididymis were weighed, respectively...
May 2015: Wei Sheng Yan Jiu, Journal of Hygiene Research
Mehmet Gökhan Ramoğlu, Sultan Kavuncuoğlu, Sibel Özbek, Esin Aldemir
AIM: The objective of this study was to examine perinatal and neonatal properties of preterm infants with a corrected age of 24-36 months who were born as a result of spontaneous and in vitro fertilization multiple pregnancies, to interrogate somatic growth properties of these infants and evaluate the factors which had an impact by comparing groups. MATERIAL AND METHODS: A total of 125 children with a birth weight below 2 500 g and a gestational age below the 37(th) gestational week 60 of whom were born as a result of in vitro fertilization multiple pregnancies and 65 of whom were born as a result of spontaneous multiple pregnancies were included in the study...
March 2014: Türk Pediatri Arşivi
Zahra Shirzadi, David E Crane, Andrew D Robertson, Pejman J Maralani, Richard I Aviv, Michael A Chappell, Benjamin I Goldstein, Sandra E Black, Bradley J MacIntosh
PURPOSE: To evaluate the impact of rejecting intermediate cerebral blood flow (CBF) images that are adversely affected by head motion during an arterial spin labeling (ASL) acquisition. MATERIALS AND METHODS: Eighty participants were recruited, representing a wide age range (14-90 years) and heterogeneous cerebrovascular health conditions including bipolar disorder, chronic stroke, and moderate to severe white matter hyperintensities of presumed vascular origin...
November 2015: Journal of Magnetic Resonance Imaging: JMRI
Tom J van Mierlo, Chin Chung, Elisabeth M Foncke, Henk W Berendse, Odile A van den Heuvel
Depression and anxiety are common in Parkinson's disease (PD), and are among the non-motor symptoms that interfere with quality of life dramatically. Motor, cognitive, and affective features overlap in PD, hampering diagnosis. To shed more light on the contribution of structural brain changes to the presence of PD-related depressive symptoms, we conducted a Voxel-Based Morphometry (VBM) study. We hypothesized that depressive symptoms in PD are related to regional gray matter (GM) volume loss within the limbic circuit...
February 2015: Movement Disorders: Official Journal of the Movement Disorder Society
Dawn C Matthews, Michelle Davies, John Murray, Schantel Williams, Wai H Tsui, Yi Li, Randolph D Andrews, Ana Lukic, Pauline McHugh, Shankar Vallabhajosula, Mony J de Leon, Lisa Mosconi
: Increased physical activity and higher adherence to a Mediterranean-type diet (MeDi) have been independently associated with reduced risk of Alzheimer's disease (AD). Their association has not been investigated with the use of biomarkers. This study examines whether, among cognitively normal (NL) individuals, those who are less physically active and show lower MeDi adherence have brain biomarker abnormalities consistent with AD. METHODS: Forty-five NL individuals (age 54 ± 11, 71% women) with complete leisure time physical activity (LTA), dietary information, and cross-sectional 3D T1-weigthed MRI, (11)C-Pittsburgh Compound B (PiB) and (18)F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans were examined...
October 2014: Advances in Molecular Imaging
Evan S Siegelman, Anil Chauhan
Magnetic resonance (MR) can characterize specific tissue subtypes, thus facilitating focal liver lesion diagnosis. Focal liver lesions that are isointense to hyperintense to liver on T1-weighted images are usually hepatocellular in origin. Chemical shift imaging can narrow the differential diagnosis by detecting the presence of lipid or iron. T2 and heavily T2-weigthed fast spin echo imaging can differentiate solid from nonsolid focal liver lesions. The authors illustrate these MR imaging pearls and the uncommon exceptions (pitfalls)...
August 2014: Magnetic Resonance Imaging Clinics of North America
G Adas, O Kemik, B Eryasar, A Okcu, M Adas, S Arikan, G Erman, A S Kemik, G Kamali, Y Dogan, E Karaoz
BACKGROUND: The aim of the study is to investigate the healing effect of the bone-marrow derived mesenchymal stem cells (BM-MSCs) on ischemic colon anastomosis in systemic application and to recovery the adverse effect of ischemia. MATERIALS AND METHODS: Fourty male Wistar Albino rats weigthing 250-300 g were divided into four equal groups (n=10 Group 1: control; ischemic left colonic anastomoses (4th day); Group 2: control; ischemic left colonic anastomoses (7th day); Group 3: ischemic left colonic anastomoses + systemic transplanted BM-MSCs (4th day); Group 4: ischemic left colonic anastomoses + systemic transplanted BM-MSCs (7th day)...
September 2013: European Review for Medical and Pharmacological Sciences
Jun Nishio, Mikiko Aoki, Yoshitsugu Tanaka, Hiroshi Iwasaki, Masatoshi Naito
Angioleiomyoma is a benign dermal or subcutaneous tumor originating from the tunica media of small veins and arteries, and rarely occurs in the hand. Because of its non-specific imaging features, a definite preoperative diagnosis is quite difficult. We present an unusual case of angioleiomyoma arising in the first web space of the right hand of a 56-year-old male. Physical examination showed a 3-cm, elastic-soft, mobile, non-tender mass. Magnetic resonance imaging (MRI) revealed a well-demarcated, subcutaneous, soft tissue mass with iso- to slightly high signal intensity relative to skeletal muscle on T1-weighted sequences and heterogenous high signal intensity with scattered foci of low signal intensity on T2-weigthed sequences...
July 2013: In Vivo
Dominik Buckert, Manuela Mariyadas, Thomas Walcher, Volker Rasche, Jochen Wöhrle, Wolfgang Rottbauer, Peter Bernhardt
In the setting of acute myocardial ischemia, the hypoperfused portion of the myocardium is in danger of becoming irreversibly injured. This portion is called the area at risk (AAR). It is of clinical interest to be able to estimate the AAR for further evaluation and improvement of different revascularization strategies. The Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease Score (APPROACH-score) has been shown to be a jeopardy score with a good performance for angiographic assessment of the myocardium supplied by a coronary vessel, representing the AAR...
August 2013: International Journal of Cardiovascular Imaging
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