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https://www.readbyqxmd.com/read/29777116/genetic-risk-score-of-common-genetic-variants-for-impaired-fasting-glucose-and-newly-diagnosed-type-2-diabetes-influences-oxidative-stress
#1
Minjoo Kim, Minkyung Kim, Limin Huang, Sun Ha Jee, Jong Ho Lee
We tested the hypothesis that the cumulative effects of common genetic variants related to elevated fasting glucose are collectively associated with oxidative stress. Using 25 single nucleotide polymorphisms (SNPs), a weighted genetic risk score (wGRS) was constructed by summing nine risk alleles based on nominal significance and a consistent effect direction in 1,395 controls and 718 patients with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes. All the participants were divided into the following three groups: low-wGRS, middle-wGRS, and high-wGRS groups...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29775641/surviving-out-of-hospital-cardiac-arrest-the-neurological-and-functional-outcome-and-health-related-quality-of-life-one-year-later
#2
Marjaana Tiainen, Jukka Vaahersalo, Markus B Skrifvars, Johanna Hästbacka, Juha Grönlund, Ville Pettilä
BACKGROUND: Data on long-term functional outcome and quality of life (QoL) after out-of-hospital cardiac arrest (OHCA) are limited. We assessed long-term functional outcome and health-related QoL of OHCA survivors regardless of arrest aetiology. METHODS: All adult unconscious OHCA patients treated in 21 Finnish ICUs between March 2010 and February 2011 were followed. Barthel Index (BI), activities of daily living (ADL), accommodation, help needed and received, working status, car driving and self-experienced cognitive deficits were assessed in 1-year survivors (N = 206, 40...
May 15, 2018: Resuscitation
https://www.readbyqxmd.com/read/29771555/the-quality-of-assessments-for-childhood-psychopathology-within-a-regional-medical-center
#3
Adam F Sattler, Jarrod M Leffler, Nicole L Harrison, Ewa D Bieber, Joseph J Kosmach, Leslie A Sim, Stephen P H Whiteside
Accurate assessment is essential to implementing effective mental health treatment; however, little research has explored child clinicians' assessment practices in applied settings. The current study thus examines practitioners' use of evidence-based assessment (EBA) instruments (i.e., self-report measures and structured interviews), specificity of identified diagnoses (i.e., use of specific diagnostic labels vs. nonstandardized labels, not otherwise specified [NOS] diagnoses, and adjustment disorder diagnoses), and documentation of Diagnostic and Statistical Manual of Mental Disorders (4th ed...
May 17, 2018: Psychological Services
https://www.readbyqxmd.com/read/29770586/surgical-infection-after-posterolateral-lumbar-spine-arthrodesis-ct-analysis-of-spinal-fusion
#4
Pablo Andrés-Cano, Ana Cerván, Miguel Rodríguez-Solera, Jose Antonio Ortega, Natividad Rebollo, Enrique Guerado
OBJECTIVE: To determine the incidence of infection after instrumented lumbar spine surgery, the demographic and surgical variables associated with acute infection, and the influence of infection and debridement on the consolidation of spinal fusion. METHODS: After obtaining approval from the hospital ethics committee, an observational study was made on a prospective cohort of consecutive patients surgically treated by posterolateral lumbar spine arthrodesis (n = 139, 2005-2011)...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29767329/validity-of-the-eq-5d-5l-and-reference-norms-for-the-spanish-population
#5
Gimena Hernandez, Olatz Garin, Yolanda Pardo, Gemma Vilagut, Àngels Pont, Mónica Suárez, Montse Neira, Luís Rajmil, Inigo Gorostiza, Yolanda Ramallo-Fariña, Juan Cabases, Jordi Alonso, Montse Ferrer
BACKGROUND AND OBJECTIVE: The EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version and provide index and dimension population-based reference norms for the new EQ-5D-5L. METHODS: Data were obtained from the 2011/2012 Spanish National Health Survey, with a representative sample (n = 20,587) of non-institutionalized Spanish adults (≥ 18 years)...
May 16, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29766545/association-of-handgrip-strength-with-various-oral-functions-in-82-to-84-year-old-community-dwelling-japanese
#6
Yusuke Mihara, Ken-Ichi Matsuda, Kazunori Ikebe, Koudai Hatta, Motoyoshi Fukutake, Kaori Enoki, Taiji Ogawa, Hajime Takeshita, Chisato Inomata, Yasuyuki Gondo, Yukie Masui, Kei Kamide, Ken Sugimoto, Mai Kabayama, Tatsuro Ishizaki, Yasumichi Arai, Yoshinobu Maeda
OBJECTIVE: The purpose of this study was to elucidate the associations between muscle strength and several oral functions in a large cohort of community-dwelling, 82- to 84-year-old community-dwelling Japanese people. BACKGROUND DATA DISCUSSING THE PRESENT STATUS OF THE FIELD: Several studies have examined the relationships between physical performance and oral functions. However, no studies have investigated the associations of muscle strength with various objectively evaluated oral functional parameters in a large cohort of very old adults...
May 15, 2018: Gerodontology
https://www.readbyqxmd.com/read/29766329/syringe-sharing-in-drug-injecting-dyads-a-cross-classified-multilevel-analysis-of-social-networks
#7
Armita Shahesmaeili, Ali Mirzazadeh, Willi McFarland, Hamid Sharifi, Ali Akbar Haghdoost, Hamid Soori
We examined the association of dyadic-level factors with syringe sharing among people who inject drugs (PWID) in Kerman, Iran. In a cross-sectional study, we collected data on 329 drug-injecting dyads by individual face-to-face interviews. An injecting dyad was defined as 2 PWID who knew each other and injected drugs together during the last 6 months. If they reported at least 1 occasion of syringe sharing, the dyad was considered high-risk. Dyadic-level factors associated with syringe sharing were assessed using cross-classified multilevel logistic regression...
May 15, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29765858/neural-stem-cell-activation-and-the-role-of-protein-synthesis
#8
REVIEW
Avni Baser, Maxim Skabkin, Ana Martin-Villalba
Adult neural stem cells are generated at embryonic stages by entering a quiescent state that allows their retention into adulthood and thereby maintenance of life-long brain homeostasis. Thus, a tight balance between the quiescence and activation state is instrumental to meet the brain demands for a specific cell type at the correct numbers, at a given time and position. Protein synthesis is the most energy-consuming process within the cell and, not surprisingly, it occurs at low rates in quiescent stem cells...
November 9, 2017: Brain Plasticity
https://www.readbyqxmd.com/read/29764676/effect-of-plantarflexion-resistance-of-an-ankle-foot-orthosis-on-ankle-and-knee-joint-power-during-gait-in-individuals-post-stroke
#9
Toshiki Kobayashi, Michael S Orendurff, Madeline L Singer, Fan Gao, Grace Hunt, K Bo Foreman
Plantarflexion resistance of an ankle-foot orthosis (AFO) plays an important role to prevent foot-drop, but its impact on push-off has not been well investigated in individuals post-stroke. The aim of this study was to investigate the effect of plantarflexion resistance of an articulated AFO on ankle and knee joint power of the limb wearing the AFO in individuals post-stroke. Gait analysis was performed on 10 individuals with chronic stroke using a Vicon 3-dimensional motion capture system and a Bertec split-belt instrumented treadmill...
May 5, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29761993/-design-and-implementation-of-real-time-continuous-glucose-monitoring-instrument
#10
Yonghong Huang, Hongying Liu, Senfu Tian, Ziru Jia, Zi Wang, Xitian Pi
Real-time continuous glucose monitoring can help diabetics to control blood sugar levels within the normal range. However, in the process of practical monitoring, the output of real-time continuous glucose monitoring system is susceptible to glucose sensor and environment noise, which will influence the measurement accuracy of the system. Aiming at this problem, a dual-calibration algorithm for the moving-window double-layer filtering algorithm combined with real-time self-compensation calibration algorithm is proposed in this paper, which can realize the signal drift compensation for current data...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29761113/differences-in-hip-joint-biomechanics-and-muscle-activation-in-individuals-with-femoroacetabular-impingement-compared-with-healthy-asymptomatic-individuals-is-level-ground-gait-analysis-enough
#11
Derek J Rutherford, Janice Moreside, Ivan Wong
Background: Femoroacetabular impingement (FAI) is a recognized cause of hip and groin pain and a significant factor in hip joint function during sport. Objective tests for understanding hip function are lacking in this population. Purpose: To determine whether biomechanical and electromyographic features of hip function during level-ground walking differ between a group diagnosed with FAI and those with no symptoms of FAI. Study Design: Controlled laboratory study...
May 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29760771/systematic-review-cultural-adaptation-and-feasibility-of-screening-for-autism-in-non-english-speaking-countries
#12
REVIEW
Turkiya S Al Maskari, Craig A Melville, Diane S Willis
Background: Screening children for autism has gained wider acceptance within clinical practice, and early intervention has improved outcomes. Increasingly, adapting an existing screening instrument is a common, fast method to create a usable screening tool, especially for countries with limited resources and/or expertise. However, concerns have been raised regarding adaptation adequacy and the feasibility of screening across cultural groups. This study systematically examined the levels of cultural adaptation and feasibility aspects considered when screening for autism in non-English speaking countries to build upon the sparse knowledge that exists on this topic in the literature...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29760679/hematocrit-values-predict-carotid-intimal-media-thickness-in-obese-patients-with-non-alcoholic-fatty-liver-disease-a-cross-sectional-study
#13
Giovanni Tarantino, Luigi Barrea, Domenico Capone, Vincenzo Citro, Teresa Mosca, Silvia Savastano
Background: Literature data suggest with some criticism that full-fledged cardiovascular (CV) events (acute or chronic) are likely predicted by blood components, which are reported to be associated with the presence/severity of non-alcoholic fatty liver disease (NAFLD). This study was aimed at determining which marker(s) derived from blood count, such as white blood cells, neutrophils, neutrophil/lymphocyte ratio, platelet count, hemoglobin, mean corpuscular volume, hematocrit values were associated with ear or subclinical atherosclerosis, in obese patients of various classes suffering from NAFLD...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29758072/sex-differences-in-associations-between-multimorbidity-and-physical-function-domains-among-community-dwelling-adults-in-singapore
#14
Lixia Ge, Chun Wei Yap, Bee Hoon Heng
OBJECTIVES: The aims of the study were to identify the associations between multimorbidity and specific physical function domains among community-dwelling adults in Singapore, and to examine sex differences in the associations. METHODS: This study was conducted using baseline data of 1,940 participants in the Population Health Index Survey conducted in the Central Region of Singapore from November 2015 to November 2016. Physical function was assessed using the Function Component of the Late-life Function and Disability Instrument and compared between men and women...
2018: PloS One
https://www.readbyqxmd.com/read/29755930/parents-attitudes-towards-topical-fluoride-and-vaccines-for-children-are-these-distinct-or-overlapping-phenomena
#15
Richard M Carpiano, Donald L Chi
Despite attention paid to parental refusal of child vaccines, the phenomenon of topical fluoride refusal is poorly understood. We examine the extent to which parent attitudes and Internet use regarding topical fluoride treatment and vaccines may overlap and, in turn, uniquely or distinctly correlate with fluoride and vaccine refusal for the child. In 2017, we analyzed data collected from 2011 to 12 for 361 children from three Washington state dental clinics. The instrument included analogous measures of topical fluoride and vaccine safety concerns, perceived severity of preventable cavities/disease, and Internet use for fluoride/vaccine information; and measures of non-fluoridated toothpaste use, attitudes towards dental x-rays and amalgam and composite fillings...
June 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29747919/temporal-trends-in-coronary-angiography-and-percutaneous-coronary-intervention-insights-from-the-va-clinical-assessment-reporting-and-tracking-program
#16
Stephen W Waldo, Madhura Gokhale, Colin I O'Donnell, Mary E Plomondon, Javier A Valle, Ehrin J Armstrong, Richard Schofield, Stephan D Fihn, Thomas M Maddox
OBJECTIVES: The aim of this study was to evaluate temporal trends in characteristics and outcomes among patients referred for invasive coronary procedures within a national health care system for veterans. BACKGROUND: Coronary angiography and percutaneous coronary intervention remain instrumental diagnostic and therapeutic interventions for coronary artery disease. METHODS: All coronary angiographic studies and interventions performed in U...
May 14, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29747639/translating-and-culturally-adapting-the-shortened-version-of-the-hospital-ethical-climate-survey-hecs-s-retaining-or-modifying-validated-instruments
#17
Pernilla Pergert, Cecilia Bartholdson, Marika Wenemark, Kim Lützén, Margareta Af Sandeberg
BACKGROUND: The Hospital Ethical Climate Survey (HECS) was developed in the USA and later shortened (HECS-S). HECS has previously been translated into Swedish and the aim of this study was to describe a process of translating and culturally adapting HECS-S and to develop a Swedish multi-professional version, relevant for paediatrics. Another aim was to describe decisions about retaining versus modifying the questionnaire in order to keep the Swedish version as close as possible to the original while achieving a good functional level and trustworthiness...
May 10, 2018: BMC Medical Ethics
https://www.readbyqxmd.com/read/29747220/the-causal-role-of-smoking-on-the-risk-of-headache-a-mendelian-randomization-analysis-in-the-hunt-study
#18
Marianne Bakke Johnsen, Bendik Slagsvold Winsvold, Sigrid Børte, Gunnhild Åberge Vie, Linda Margareth Pedersen, Kjersti Storheim, Frank Skorpen, Knut Hagen, Johan Håkon Bjørngaard, Bjørn Olav Åsvold, John Anker Zwart
BACKGROUND: Headache has been associated with various lifestyle- and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity and headache is likely to be causal. METHOD: 58 316 participants from the Nord-Trøndelag Health Study (HUNT) with information on headache status were genotyped for the rs1051730 C>T single-nucleotide polymorphism (SNP). The SNP was used as an instrument for smoking intensity in a Mendelian randomization (MR) analysis...
May 10, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29744920/diabetes-and-ischaemic-stroke-outcome
#19
E L MacDougal, W H Herman, J J Wing, L B Morgenstern, L D Lisabeth
AIM: To compare all-cause mortality, stroke recurrence and functional outcomes in people who have experienced stroke, with and without diabetes. METHODS: We captured data on population-based ischaemic strokes (2006-2012) in Nueces County, Texas. Data were collected from participant interviews and medical records. Differences in cumulative mortality and stroke recurrence risk by diabetes status were estimated at 30 days and 1 year using Cox models. Differences in 90-day functional outcomes (activities of daily living/instrumental activities of daily living score: range 1-4; higher scores worse) by diabetes status were assessed using Tobit regression...
May 9, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29744723/micro-ct-evaluation-of-different-final-irrigation-protocols-on-the-removal-of-hard-tissue-debris-from-isthmus-containing-mesial-root-of-mandibular-molars
#20
Emmanuel João Nogueira Leal Silva, Carla Rodrigues Carvalho, Felipe Gonçalves Belladonna, Marina Carvalho Prado, Ricardo Tadeu Lopes, Gustavo De-Deus, Edson Jorge Lima Moreira
OBJECTIVES: This study aimed to compare four final irrigation protocols (passive ultrasonic irrigation [PUI], EndoVac, Self-Adjusting File [SAF] and EasyClean) on the removal of accumulated hard-tissue debris (AHTD) from mesial canals of mandibular molars through microcomputed tomographic (micro-CT) analysis. MATERIALS AND METHODS: Forty mesial roots of mandibular molars presenting isthmuses type I or III were scanned in a micro-CT device and instrumented up to Reciproc R40 instrument...
May 10, 2018: Clinical Oral Investigations
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