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https://www.readbyqxmd.com/read/28645016/quantitative-analysis-of-a-biopharmaceutical-protein-in-cell-culture-samples-using-automated-capillary-electrophoresis-ce-western-blot
#1
Dong Xu, Kentaro Marchionni, Yunli Hu, Wei Zhang, Zoran Sosic
An effective control strategy is critical to ensure the safety, purity and potency of biopharmaceuticals. Appropriate analytical tools are needed to realize such goals by providing information on product quality at an early stage to help understanding and control of the manufacturing process. In this work, a fully automated, multi-capillary instrument is utilized for size-based separation and western blot analysis to provide an early readout on product quality in order to enable a more consistent manufacturing process...
June 15, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28642722/revision-of-audit-consumption-items-to-improve-the-screening-of-youth-binge-drinking
#2
María-Teresa Cortés-Tomás, José-Antonio Giménez-Costa, Patricia Motos-Sellés, María-Dolores Sancerni-Beitia
This study analyzes the appropriateness of an improved version of one of the most frequently used instruments for the screening of high-risk alcohol consumption. This adaptation was created in accordance with certain limitations recognized by other researchers and in an attempt to adjust the content and scales of some items to a more consensual definition of binge drinking. After revising items 2 and 3, the areas under the ROC curves of the AUDIT and of different abbreviated versions were calculated. A total of 906 minors (468 females) between the ages of 15 and 17 were evaluated...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28642039/development-and-validation-of-a-screening-instrument-to-identify-cardiometabolic-predictors-of-mortality-in-older-individuals-with-cancer-secondary-analysis-of-the-australian-longitudinal-study-of-ageing-alsa
#3
Ethel Lim, Michelle Miller, Billingsley Kaambwa, Bogda Koczwara
OBJECTIVE: The objective of this study was to identify significant cardiometabolic predictors of mortality among older cancer survivors and develop and validate a screening instrument to assess individual risk of mortality. MATERIALS AND METHODS: Retrospective cohort study used collected data from the ALSA. Cox proportional hazards model was used to derive the risk equation for mortality that could be evaluated at 10years. Measures of discrimination and calibration were calculated in the validation cohort...
June 19, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28640211/a-novel-active-imaging-model-to-design-visual-systems-a-case-of-inspection-system-for-specular-surfaces
#4
Jorge Azorin-Lopez, Andres Fuster-Guillo, Marcelo Saval-Calvo, Higinio Mora-Mora, Juan Manuel Garcia-Chamizo
The use of visual information is a very well known input from different kinds of sensors. However, most of the perception problems are individually modeled and tackled. It is necessary to provide a general imaging model that allows us to parametrize different input systems as well as their problems and possible solutions. In this paper, we present an active vision model considering the imaging system as a whole (including camera, lighting system, object to be perceived) in order to propose solutions to automated visual systems that present problems that we perceive...
June 22, 2017: Sensors
https://www.readbyqxmd.com/read/28636163/the-pu-prom-a-patient-reported-outcome-measure-for-peptic-ulcer-disease
#5
Na Liu, Jing Lv, Jinchun Liu, Yanbo Zhang
OBJECTIVE: Patient-reported outcome measure (PROM) conceived to enable description of treatment-related effects, from the patient perspective, bring the potential to improve in clinical research, and to provide patients with accurate information. Therefore, the aim of this study was to develop a patient-centred peptic ulcer patient-reported outcome measure (PU-PROM) and evaluate its reliability, validity, differential item functioning (DIF) and feasibility. METHOD: To develop a conceptual framework and item pool for the PU-PROM, we performed a literature review and consulted other measures created in China and other countries...
June 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28634500/stroke-performance-measures-do-not-predict-functional-outcome
#6
Eric E Adelman, Lynda D Lisabeth, Melinda A Smith, Jonggyu Baek, Erin C Case, Brisa N Sánchez, James F Burke, Lesli E Skolarus, Darin B Zahuranec, William J Meurer, Devin L Brown, Kevin A Kerber, Deborah A Levine, Nelda M Garcia, Morgan S Campbell, Lewis B Morgenstern
BACKGROUND AND PURPOSE: Poststroke functional outcome is critical to stroke survivors. We sought to determine whether adherence to current stroke performance measures is associated with better functional outcome 90 days after an ischemic stroke. METHODS: Utilizing the Brain Attack Surveillance in Corpus Christi cohort, we examined adherence to 7 ischemic stroke performance measures from February 2009 to June 2012. Adherence to the measures was analyzed in aggregate using a binary defect-free score and an opportunity score, representing the proportion of eligible measures met...
July 2017: Neurohospitalist
https://www.readbyqxmd.com/read/28631699/-lower-extremity-venous-diseases-in-primary-knee-osteoarthritis
#7
O M Lesnyak, E V Zubareva, M G Goncharova, D M Maksimov
AIM: To establish a possible association between knee osteoarthritis (OA) and lower extremity venous diseases ((LEVDs) on the basis of thorough clinical and instrumental studies. SUBJECTS AND METHODS: A case-control study recruiting 40-60-year-old women was conducted. A study group included 85 women with knee OA; a control group consisted of 50 women without this condition. The patients of both groups underwent assessment of complaints and goal-directed objective examination to identify joint diseases and chronic LEVDs, knee X-ray study, and duplex scanning of the lower extremity veins...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28630701/evaluation-of-an-in-vitro-fibre-fermentation-method-using-feline-faecal-inocula-inter-individual-variation
#8
Guido Bosch, Lisa Heesen, Karine de Melo Santos, John W Cone, Wilbert F Pellikaan, Wouter H Hendriks
The present study aimed to evaluate the inter-individual variability in fermentation of standard fibrous substrates by faecal inocula from ten healthy adult female cats. Substrates were citrus pectin (CP), fructo-oligosaccharides (FOS), guar gum (GG), sugar beet pulp (SBP) and wheat middlings (WM). Each substrate was incubated with faecal inoculum from each cat. Gas production was measured continuously during the 48 h incubation and SCFA and organic matter disappearance (only SBP and WM) after incubation. Out of ten cats, nine produced faeces on the days of inoculum preparation...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28628750/ergonomic-benefits-from-a-laparoscopic-instrument-with-rotatable-handle-piece-depend-on-the-area-of-the-operating-field-and-working-height
#9
Benjamin Steinhilber, Florian Reiff, Robert Seibt, Monika A Rieger, Peter Martus, Bernhard Kraemer, Ralf Rothmund
Objective To evaluate the effect of a laparoscopic instrument with a 360° rotatable handle piece (rot-HP) on biomechanical stress and precision in different areas of a simulated operating field at two working heights. Background Surgeons performing laparoscopic procedures are exposed to biomechanical stress and have an increased risk of musculoskeletal complaints. Method Fifty-seven healthy subjects (27 men, median age 26) without experience in laparoscopy performed a precision task in four quadrants (A-D) of the operating field using the rot-HP or a common fixed handle piece (fixed-HP) at an individually adjusted lower or higher working height...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28628533/the-association-between-activity-limitation-stages-and-admission-to-facilities-providing-long-term-care-among-older-medicare-beneficiaries
#10
Jibby E Kurichi, Joel E Streim, Dawei Xie, Sean Hennessy, Ling Na, Debra Saliba, Qiang Pan, Pui L Kwong, Hillary R Bogner
OBJECTIVE: This study aimed to examine whether activity limitation stages are associated with admission to facilities providing long-term care (LTC). DESIGN: Cohort study using Medicare Current Beneficiary Survey data from the 2005-2009 entry panels. A total of 14,580 community-dwelling Medicare beneficiaries 65 years or older were included. Proportional subhazard models examined associations between activity limitation stages and time to first LTC admission, adjusting for baseline sociodemographics and health conditions...
July 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28628372/suicide-intervention-training-for-college-staff-program-evaluation-and-intervention-skill-measurement
#11
Laura Shannonhouse, Yung-Wei Dennis Lin, Kelly Shaw, Reema Wanna, Michael Porter
OBJECTIVE: Suicide remains a pressing issue for college communities. Consequently, gate-keeper trainings are often provided for staff. This study examines the effect of one such program, Applied Suicide Intervention Skills Training (ASIST). PARTICIPANTS: 51 college employees received ASIST in August of 2014 and were compared to 30 wait-list control participants. METHODS: MR-ANOVA were used to analyze pre- and post-training: (a) skills at responding to students-at-risk; (b) attitudes towards suicide; (c) knowledge about suicide; and (d) comfort/competence/confidence at helping a student-at-risk...
June 19, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28625382/impact-of-continuous-positive-airway-pressure-and-oxygen-on-health-status-in-patients-with-coronary-heart-disease-cardiovascular-risk-factors-and-obstructive-sleep-apnea-a-heart-biomarker-evaluation-in-apnea-treatment-heartbeat-analysis
#12
Eldrin F Lewis, Rui Wang, Naresh Punjabi, Daniel J Gottlieb, Stuart F Quan, Deepak L Bhatt, Sanjay R Patel, Reena Mehra, Roger S Blumenthal, Jia Weng, Michael Rueschman, Susan Redline
INTRODUCTION: Obstructive sleep apnea (OSA) is associated with impaired health-related quality of life (HRQL). Treatment with continuous positive airway pressure (CPAP) has variable impacts on HRQL, and this may be influenced by patient's tolerance of therapy. The objective is to determine the impact of nocturnal supplemental oxygen (NSO) and CPAP on HRQL compared with healthy lifestyle education (HLSE) in individuals with OSA. METHODS: Patients with coronary heart disease (CHD) or at least 3 major CHD risk factors with apnea-hypopnea index of 15 to 50 events/h were randomized to CPAP, NSO, or HLSE...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28623911/moderate-mental-illness-as-a-predictor-of-chronic-disease-prevention-and-screening
#13
Ginetta Salvalaggio, Christopher Meaney, Rahim Moineddin, Eva Grunfeld, Donna Manca
BACKGROUND: Primary care plays a pivotal role in the provision of both mental health care and chronic disease prevention and screening (CDPS). Unfortunately, moderate mental illness (MMI) is associated with poorer general health outcomes. Part of this burden of illness may be due to reduced CDPS uptake. The Building on the Existing Tools to Improve Chronic Disease Prevention in Primary Care (BETTER) trial recruited 777 participants ages 40-65 from 32 family practice panels, of whom 135 (18...
June 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28623635/italian-cultural-adaptation-of-the-memorial-anxiety-for-prostate-cancer-scale-for-the-population-of-men-on-active-surveillance
#14
Maria F Alvisi, Claudia Repetto, Tiziana Rancati, Fabio Badenchini, Tiziana Magnani, Cristina Marenghi, Silvia Villa, Nicola Nicolai, Roberto Salvioni, Barbara Avuzzi, Riccardo Valdagni, Lara Bellardita
PURPOSE: The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) is a self-report questionnaire that was developed in English to assess prostate cancer (PCa)-related anxiety. The aim of this study was to perform a cultural adaptation for the tool to be used in a population of Italian men on active surveillance (AS). METHODS: A total of 222 patients with localized PCa who were recruited for the Prostate Cancer Research International: Active Surveillance (PRIAS) protocol completed the MAX-PC...
June 14, 2017: Tumori
https://www.readbyqxmd.com/read/28623434/-cost-analysis-as-a%C3%A2-tool-for-assessing-the-efficacy-of-intensive-care-units
#15
T Maierhofer, F Pfisterer, A Bender, H Küchenhoff, O Moerer, H Burchardi, W H Hartl
BACKGROUND: The German "Hospital Structure Act" intends to align the state hospital planning on quality criteria. Within this process cost-utility analyses (CUAs) shall be used to assess the efficacy of medical care. To be objective, CUAs of intensive care units (ICUs) require standardization (adjustment) of costs. The present study analyzed the extent to which treatment costs are related to patient-specific baseline variables (such as type and severity of the primary disease). METHODS: From 2000-2004, a bottom-up procedure was used to quantify total costs on 14 ICUs in nine German university hospitals...
June 16, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28622143/epidural-analgesia-at-trial-of-labor-after-cesarean-tolac-a-significant-adjunct-to-successful-vaginal-birth-after-cesarean-vbac
#16
Sorina Grisaru-Granovsky, Maayan Bas-Lando, Lior Drukker, Fred Haouzi, Rivka Farkash, Arnon Samueloff, Alexander Ioscovich
INTRODUCTION: Epidural analgesia has been considered a risk factor for labor dystocia at trial of labor after cesarean (TOLAC) and uterine rupture. We evaluated the association between exposure to epidural during TOLAC and mode of delivery and maternal-neonatal outcomes. MATERIALS AND METHODS: A single center retrospective study of women that consented to TOLAC within a strict protocol between 2006 and 2013. Epidural "users" were compared to "non-users". Primary outcome was the mode of delivery: repeat in-labor cesarean or vaginal birth after cesarean (VBAC)...
June 5, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28615902/translation-and-adaptation-of-stroke-aphasia-depression-questionnaire-10-to-hindi
#17
Harsimarpreet Kaur, Sakshi Chopra, R M Pandey, Rohit Bhatia, Ashima Nehra
BACKGROUND: Depression is one of the most researched emotional responses after stroke and shows that the emotional impact of aphasia can have a marked negative impact on recovery, response to rehabilitation, and psychosocial adjustment. There is an evident dearth of validated instruments to assess depression in people with aphasia including Hindi, the national language of the country. AIMS: The aim of this study was to translate and adapt the original English version of widely used hospital version of Stroke Aphasia Depression Questionnaire (SADQ-10) to Hindi...
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28615272/what-do-adolescents-with-asthma-really-think-about-adherence-to-inhalers-insights-from-a-qualitative-analysis-of-a-uk-online-forum
#18
Anna De Simoni, Robert Horne, Louise Fleming, Andrew Bush, Chris Griffiths
OBJECTIVE: To explore the barriers and facilitators to inhaled asthma treatment in adolescents with asthma. DESIGN: Qualitative analysis of posts about inhaler treatment in adolescents from an online forum for people with asthma. Analysis informed by the Perceptions and Practicalities Approach. PARTICIPANTS: Fifty-four forum participants (39 adolescents ≥16 years, 5 parents of adolescents, 10 adults with asthma) identified using search terms 'teenager inhaler' and 'adolescent inhaler'...
June 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28611711/english-validation-of-the-parental-socialization-scale-espa29
#19
Isabel Martínez, Edie Cruise, Óscar F García, Sergio Murgui
Parenting styles have traditionally been studied following the classical two-dimensional orthogonal model of parental socialization. The Parental Socialization Scale ESPA29 is used to measure the four styles of parental socialization through the acceptance/involvement and strictness/imposition dimensions. The ESPA29 scale is a developmentally appropriate measure of parenting styles, which has been validated in several languages including Spanish, Italian, and Brazilian Portuguese. In this study, the English translation of the ESPA29 was evaluated...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28609804/psychometric-properties-of-brief-screening-tests-for-alcohol-use-disorders-during-pregnancy-in-argentina
#20
Mariana Beatriz López, Aldana Lichtenberger, Karina Conde, Mariana Cremonte
Background Considering the physical, mental and behavioral problems related to fetal alcohol exposure, prenatal clinical guides suggest a brief evaluation of alcohol consumption during pregnancy to detect alcohol intake and to adjust interventions, if required. Even if any alcohol use should be considered risky during pregnancy, identifying women with alcohol use disorders is important because they could need a more specific intervention than simple advice to abstain. Most screening tests have been developed and validated in male populations and focused on the long-term consequences of heavy alcohol use, so they might be inappropriate to assess consumption in pregnant women...
June 13, 2017: Revista Brasileira de Ginecologia e Obstetrícia
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